| Date | Titre | Durée | |
|---|---|---|---|
| 12 May 2021 | TWiN 18: Autism and the gut microbiome with Mauro Costa-Mattioli | 01:10:52 | |
Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 03 Jan 2023 | TWiN 36: Unbearable neurologists | 01:29:33 | |
TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 04 Apr 2022 | TWiN 28: Oligodendrocyte performance enhancing exosomes | 01:13:59 | |
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Click arrow to play Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 28 May 2024 | TWiN 51: Sensory processing dysfunction in autism spectrum disorders | 01:11:20 | |
TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 24 May 2022 | TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease | 01:09:52 | |
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 14 Jul 2021 | TWiN 20: Drifting aromas in the brain | 01:18:08 | |
While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 13 Jun 2020 | TWiN 7: Stress, the good, bad and beautiful | 01:24:13 | |
The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses. Hosts: Ori Lieberman, Jason Shepherd, Erin Calipari and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for the episode
Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 18 Dec 2019 | TWiN 3: Gambling on dopamine | 01:20:59 | |
Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction. Hosts: Ori Lieberman, Erin Calipari,Jason Shepherd, and Vincent Racaniello Click arrow to play Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv | |||
| 02 Apr 2025 | TWiN 59: AI co-scientist | 01:14:45 | |
Tim explains AI co-scientist, a tool released by Google, which it hopes to help scientists generate hypotheses and research proposals, and to accelerate the speed of scientific and biomedical discoveries. Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 14 Oct 2020 | TWiN 11: A dollar per neuron | 01:06:21 | |
Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron. Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello Guest: Maria Tosches Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 28 Dec 2021 | TWiN 25: Thanks for listening | 01:02:44 | |
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 01 Oct 2024 | TWiN 54: How pregnancy transforms the brain | 01:05:25 | |
TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting. Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 23 Jan 2023 | TWiN 37: Microglia at the crossroads | 01:15:05 | |
TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 18 Jul 2023 | TWiN 42: Therapeutic effects of psychedelic drugs | 00:56:34 | |
TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Click arrow to play Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 04 Oct 2023 | TWiN 43: Pavlovian opioid tolerance | 01:02:41 | |
TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 02 May 2022 | TWiN 29: Astrocytes close the critical period | 01:02:05 | |
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 29 Jan 2024 | TWiN 47: Walking after spinal cord injury | 00:55:25 | |
TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 26 Oct 2019 | TWiN 1: The ultimate challenge | 00:43:51 | |
The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv | |||
| 28 Oct 2024 | TWiN 55: A brain circuit for day/night balance | 01:09:29 | |
TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change. Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 21 Apr 2021 | TWiN 17: Worms see the light with Michael Nitabach | 01:21:59 | |
Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Michael Nitabach Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 02 Nov 2023 | TWiN 44: ADHD and persistent pain | 01:00:41 | |
TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 29 Sep 2021 | TWiN 22: It's never lupus | 01:08:17 | |
TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 07 Jul 2020 | TWiN 8: Replacing lost neurons | 01:11:25 | |
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 03 Mar 2022 | TWiN 27: Eyes wired to the auditory cortex | 01:03:47 | |
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex. Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 06 Dec 2022 | TWiN 35: Neuromodulation in treatment-resistant depression | 01:09:13 | |
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. Hosts: Jason Shepherd and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 17 Feb 2021 | TWiN 15: Microbiome and neurodevelopment with Helen Vuong | 00:49:33 | |
Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello Guest: Helen Vuong Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 10 Mar 2025 | TWiN 58: Tongue-dragging rescue behavior | 01:14:21 | |
TWiN explains a study showing that when a mouse is confronted with an unconscious conspecific, it engages in behavior including tongue-dragging to resuscitate the animal via a tongue-brain connection. Hosts: Vincent Racaniello, Tim Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 24 Jun 2024 | TWiN 52: Probiotic improves social behavior in children with ASD | 01:05:50 | |
Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD. Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 27 Mar 2023 | TWiN 38: Bacterial immunity heals sensory neurons | 01:04:57 | |
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A. Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 19 Feb 2024 | TWiN 48: Traumatic brain injury and retroviruses | 00:51:13 | |
TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 11 Nov 2020 | TWiN 12: A gene for short-term memory | 01:12:57 | |
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell. Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 30 Sep 2022 | TWiN 34: Microglia vital after spinal cord injury | 01:09:17 | |
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 11 May 2023 | TWiN 40: Dopamine organizes behavior's syllables | 01:04:17 | |
Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 15 Dec 2020 | TWiN 13: mRNAs for long-term memory | 01:08:29 | |
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 31 Oct 2021 | TWiN 23: Peripheral nervous system with Bruce Carter | 01:11:20 | |
Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Guest: Bruce Carter Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 31 Aug 2022 | TWiN 33: Viruses leaving the brain | 00:58:11 | |
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 05 Nov 2019 | TWiN 2: Cells that fire together wire together | 01:25:33 | |
The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing. Hosts: Ori Lieberman, Andres Bendesky,Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv | |||
| 09 Jan 2020 | TWiN 4: It's a trap! | 01:08:15 | |
Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons. Hosts: Andres Bendesky, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv | |||
| 20 Jun 2023 | TWiN 41: Alzheimer's and melanin-concentrating hormone | 01:18:30 | |
Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 18 Apr 2020 | TWiN 5: Anosmia and COVID-19 | 00:58:53 | |
Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, Erin Calipari and Vincent Racaniello Guest: Bob Datta Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv | |||
| 13 Dec 2023 | TWiN 45: Acupuncture modulates the immune system | 00:52:24 | |
TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 11 Aug 2020 | TWiN 9: COVID-19 neurology with Genna Waldman | 01:06:33 | |
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello Guest: Genna Waldman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 29 Jul 2024 | TWiN 53: Slowing time by cooling the brain | 01:10:03 | |
Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest: Joseph J. Paton and Felipe Rodrigues Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 29 Sep 2020 | TWiN 10: Remodeling synapses with a cytokine | 01:07:23 | |
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation. Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 21 Jun 2021 | TWiN 19: Glia 101 | 01:12:54 | |
On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 24 Aug 2021 | TWiN 21: How do we know if a mouse is hallucinating? | 01:28:02 | |
TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 14 Jan 2021 | TWiN 14: Reducing Alzheimer-like pathology in mice | 01:10:52 | |
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation. Hosts: Ori Lieberman, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 25 Mar 2024 | TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all? | 01:31:25 | |
TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 24 Nov 2021 | TWiN 24: Social transmission of maternal behavior with Ioana Carcea and Robert Froemke | 01:12:47 | |
Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin. Hosts: Vincent Racaniello and Timothy Cheung Guests: Ioana Carcea and Robert Froemke Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe | |||
| 29 Jun 2022 | TWiN 31: HIV-1 co-receptor shapes window for memory linking | 01:11:52 | |
TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 04 Feb 2025 | TWiN 57: Repetitive injury, herpes, and Alzheimer's | 00:40:09 | |
TWiN discusses a study showing that repetitive injury reactivates HSV-1 in a human brain tissue model and induces phenotypes associated with Alzheimer’s disease. Hosts: Vincent Racaniello and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 29 Apr 2024 | TWiN 50: Neurological sequelae after COVID-19 | 01:04:25 | |
TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 26 Nov 2024 | TWiN 56: Astrocytes help neurons remember | 01:00:44 | |
TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall. Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 20 May 2020 | TWiN 6: Neural control of sexual behavior | 01:04:03 | |
Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes. Hosts: Ori Lieberman, Andres Bendesky, andJason Shepherd Guest: Nirao Shah Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode
Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv | |||
| 31 Jan 2022 | TWiN 26: Immunological memory in the brain | 00:53:49 | |
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Become a patron of TWiN! Links for this episodeMusic is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 02 Aug 2022 | TWiN 32: Relearning how to move after stroke | 00:59:47 | |
TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together. Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 28 Apr 2023 | TWiN 39: Virus-like capsids trigger paraneoplastic disease | 00:52:39 | |
Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
| 01 Jan 2024 | TWiN 46: Neuronal activity promotes glioma progression | 00:51:04 | |
TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode
Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv | |||
