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DateTitreDurée
08 Feb 2018170: Rats, lice, and nanoparticles 00:55:54

The TWiM team reveals that spread of plague was likely by human ectoparasites, not rats, and deconstruct a durable, broadly protective protein nanoparticle influenza virus vaccine.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Become a patron of TWiM.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 

13 Sep 2012TWiM #41: ICAAC live in San Francisco01:43:08

Vincent and Michael travel to San Francisco for the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), where they meet with Bill, John, and Victor to discuss tuberculosis, monitoring infectious disease outbreaks with online data, and outside-the-box approaches to antibacterial therapy.


11 Sep 2020225: Lag phase is no slouch01:03:00

The TWiM team explores how delivery of an enzyme into competitor cells leads to synthesis of (p)ppApp, depletion of ATP, deregulation of metabolic pathways, and cell death, and a refinement of our typical view of bacterial lag phase as a period of nonreplication.

Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt

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Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

28 Feb 2025328: Capturing Shigella With Filopodia00:46:59

TWiM describes Shigella infection is facilitated by interaction of human enteric α-defensin 5 with a colonic epithelial receptor, and an amino acid change in RNA polymerase that leads to resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email.

Become a patron of TWiM.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

06 Feb 2020212: A coronavirus outbreak and IRF4 deficiency in Whipple’s disease00:55:26

The TWiM team reviews the coronavirus outbreak that began in Wuhan, China, and the finding that an IRF deficiency underlies Whipple’s disease. 

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

01 Jun 2019198: Unexpectedly pathogenic bacteriophages01:00:23

The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance.

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

24 Mar 2023283: Quorum Sensing In The Gut00:58:07

TWiM reveals quorum-sensing systems that regulate intestinal inflammation and permeability caused by P. aeruginosa, and how plasmids manipulate bacterial behavior through translational regulatory crosstalk.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.

Become a patron of TWiM.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

05 Feb 2021235: Green algae and fatty acids01:04:41

In this episode, how DNA of giant viruses has contributed extensively to the genome of green algae, and inhibition of E. coli virulence by a metabolic product of arachidonic acid in the intestinal epithelium.

Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

28 Aug 2020224: One hundred million year old bacteria01:15:03

The TWiM team reveals the genetic mysteries of the Dead Sea Scrolls from sequencing of DNA, and 100 million year old living bacteria recovered from marine sediments.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

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Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

09 Aug 2018182: A micro story with macro implications01:05:47

The TWiM hosts reveal how to test antimicrobial susceptibility in less than 30 minutes, and a carbonate-sensitive phytotransferrin in diatoms that controls iron uptake.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

21 Aug 2013TWiM #62: Breaking bad and protein chain mail 01:19:54

Vincent and Michael discuss how infection with influenza A virus disperses Streptococcus pneumoniae biofilms leading to disease, and an amazing protein chainmail in a viral capsid 

03 Apr 2020214: Masterful subversion00:58:37

Vincent, Elio and Michael reveal the ASM COVID-19 summit, and how Salmonella injects a protein into the cell to drive suppression of the immune response.

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.

Become a patron of TWiM.

09 Jul 2015TWiM #107: The battle in your bladder01:31:06

Hosts: Vincent Racaniello and Michael Schmidt.

Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

29 Dec 2016TWiM #142: A membrane-thickness caliper00:58:37

Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness.

Hosts: 

Vincent Racaniello, Elio Schaechter, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv 

21 Nov 2021255: Fleaing The Plague00:52:35

TWiM reveals a study showing that positive interactions among bacteria are far more common than previously thought, and how acquisition of a single gene enabled Yersinia pestis to expand the range of mammalian hosts that sustain flea-borne plague.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email.

Become a Patron of TWiM!

Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

31 Jan 2019193: Persisters01:00:45

The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment.

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. 

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

20 Nov 2015TWiM #115: Profiling the Poglianos00:56:23

Vincent visits the laboratories of Kit and Joseph Pogliano on the campus of the University of California, San Diego, where he learns about their work on the bacterial cytoskeleton, sporulation, and the effects of antibiotics on bacterial cells.

Visit microbeworld.org/twim for complete shownotes including the special video version of this episode. Thanks for listening and watching!

12 Jul 2019200: In the company of Elio01:01:26

Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms.

VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app.

Become a patronof TWiM.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 

11 Oct 2024319: The Dark Side of the Rumen00:52:03

TWiM explains a project to engineer the cow microbiome to reduce emissions of methane, and the finding of antibiotic resistance genes in the genomes of giant viruses.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

Subscribe to TWiM (free) on Apple Podcasts, Spotify, Android, RSS, or by email.

Become a patron of TWiM.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

15 Dec 2016TWiM #141: Nutritional immunity and polymicrobial infections01:05:54

Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity.

Hosts: 

Vincent Racaniello, Elio Schaechter, and Michael Schmidt.

Guest: Jennifer Bomberger

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This show is sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 

27 Nov 2014TWiM #92: Flying biofilms01:08:06

Vincent, Elio, Michael and Michele discuss the possible eradication of wild poliovirus type 3, and how microsporidian parasites prevent locust swarming behavior.

 

16 Nov 2023298: Impact of Lung Microbiome and Racial Disparities on Asthma00:59:47

TWiM provides thoughts on providing better training for a non-academic career, and help celebrate Black in Microbiology Week with a 2023 paper by Ari Kozik, a co-founder of Black Microbiologists Association and Assistant Professor at the University of Michigan

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,

Become a patron of TWiM.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

05 Aug 2016TWiM #132: Bacteria learn long division00:57:25

Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires.

Hosts: Vincent RacanielloMichele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 

16 Jan 2016TWiM #119: Power of one01:03:25

Hosts: Vincent RacanielloMichael Schmidt, and Elio Schaechter.

The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode 

This episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.

Thumbnail image: Cell structure of a gram positive bacterium. This vector image is completely made by Ali Zifan - Own work; used information from Biology 10e Textbook (chapter 4, Pg: 63) by: Peter Raven, Kenneth Mason, Jonathan Losos, Susan Singer · McGraw-Hill Education.

 

18 Jul 2012TWiM #37: Microbial Jekyll and Hyde01:17:43

Vincent, Jo, Michael, and Elio discuss two examples of dynamic microbial symbioses that switch between mutualistic and pathogenic states.

08 Feb 2012TWiM #26: Suum cuique01:15:05

Vincent, Elio, and Michael discuss the finding of Sutterella species in the gut of autistic children, and methods for cultivating oral bacteria. 

07 Sep 2018184: CRISPR-Cas immune systems01:26:09

Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University.

Host: Vincent Racaniello

Guest: Sam Sternberg

 Become a Patron of TWiM!

Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

21 Sep 2017TWiM #161: Eros, a bacterial aphrodisiac 00:55:56

From the TWiM team, a discussion of Hurricane Harvey microbiology, and a bacterial enzyme that induces eukaryotic mating.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM. Two S. rosetta cells touching, a prelude to mating

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

24 May 2013TWiM #56: Live at ASM in Denver01:42:04

Vincent, Elio and Michael recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Andrew, Ferric, Suzanne, and Michelle about their research on a phage system for evading innate immunity, retractions of research papers, bacterial infections of the eye, and cytoplasmic defenses against intracellular bacteria.

This episode was filmed live at ASM GM 2013 in Denver, CO. Visit www.microbeworld.org/asmlive to watch the full video archive of this episode as well as all the videos recorded during GM. 

20 May 2022256: Antiviral Hotspots and Desiccation Tolerance00:56:48

TWiM explains the discovery of hotspots of genetic variation containing reservoirs of anti-phage systems in E. coli phages and their parasitic satellites, and pathogen desiccation tolerance promoted by hydrophilins.

Become a patron of TWiM.

Links for this episode

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

09 Mar 2011TWiM #2: The plague, microbial virulence and the gut microbiome01:15:43

Vincent, Cliff, and Michael review a fatal laboratory acquired Yersinia pestis infection, and how gut bacteria control body weight and metabolic activity.

18 Mar 2015TWiM #100: Omnis cellula e cellula00:50:38

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Jo Handelsman.  

The TWiM team celebrates 100 episodes with a Talmudic question, and discussion of how a single mutation alters bacterial host tropism.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

Image: Yellow colonies of S. aureus on a blood agar plate, note regions of clearing around colonies caused by lysis of red cells in the agar By: HansN. on wikimedia. From the study (Nat Gen) "...only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits." 

03 Nov 2016TWiM #138: Learning to love uranium and the A-baum01:02:09

The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii.

Hosts: 

Vincent Racaniello, Michael SchmidtElio Schaechter, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 

31 Oct 2019208: Georgia Tech microbial01:22:50

Hosts: Vincent Racaniello, Michele Swanson and Michael Schmidt

Guests: Deanna Beatty, Mark Hay, Gina Lewin, Frank Stewart, and Marvin Whiteley

At Georgia Tech, members and trainees of the Center for Microbial Dynamics and Infection discuss the identification of pathogen essential genes during coinfections, and how coral management can improve coral defenses against pathogens.

Become a patron of TWiM.

Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

 

02 Feb 2016TWiM #120: Snakes in trouble00:49:02

Hosts: Vincent Racaniello and Elio Schaechter.

Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode 

This episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.

 

05 May 2023286: Integrons and Invasion00:52:46

TWiM reveals environmental integrons, bacterial genetic elements notorious for their role in spreading antibiotic resistance, and how Salmonella invasion is controlled by competition among intestinal chemical signals.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

Become a patron of TWiM.

Links for this episode

Music used on TWiM is by Ronald Jenkees.

Send your microbiology questions and comments to twim@microbe.tv

10 Oct 2012TWiM #43: Bacterial caveolae and zapping acne with phages01:19:46

Vincent, Michael, Elio review formation of caveolae in a bacterium, and the limited genetic diversity and broad killing activity of P. acnes bacteriophages.

05 Jun 2013TWiM #57: Updating the human gut microbiome to degrade seaweed00:58:34

Vincent, Elio and Michael discuss fungi that use pheromones to trap nematodes, and how genes obtained from marine bacteria help gut bacteria degrade algal carbohydrates. 

10 Sep 2021250: E-scaffolds and paper stickers01:05:03

On this episode, an electrochemical scaffold that delivers safe doses of hypochlorous acid to treat wound infections in humans, and a method for sampling and monitoring bacteria and viruses on surfaces using plain paper stickers.

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt

Links:

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

04 Sep 2013TWiM #63: Superantigens, S. aureus, and the armpit microbiome01:26:01

Vincent, Michael, and Michelle discuss how a Staphylococcus aureus superantigen is critical for pathogenesis in a rabbit model, and the relationship of body odor to the axilla microbiome.

25 Dec 2014TWiM #94: Nitrochondria01:06:50

Vincent, Elio, and Michael discuss a symbiosis between a nitrogen-fixing cyanobacteria and a single-celled eukaryotic alga.

 

Links for this episode:

 

Visit microbeworld.org/twim to view the complete shownotes and entire back catalog.

03 Jul 2021245: Bacteria that protect bees from fungi00:50:14

In this episode, how polysaccharides keep cyanobacteria afloat in the oceans so that they can carry out photosynthesis, and a symbiotic bacterium that protects honey bees from fungal infections.

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Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

27 Nov 2020230: Ancient bacterial DNA00:55:39

In this episode of TWiM, control of Campylobacter in raw chicken by zinc oxide nanoparticles in packaging material, and Salmonella enterica genomes from a16th century epidemic in Mexico.

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Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

 

28 Dec 2011TWiM #23: Fighting antibiotics with toxic gas and starvation01:16:05

Vincent, Jo, Elio, and Michael explain how a swarming bacterium helps disperse a non-motile fungus, and bacterial antibiotic tolerance mediated by hydrogen sulfide and starvation responses.

22 Jan 2014TWiM #71: Colon cancer’s little shop of horrors01:18:38

Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.

25 Oct 2024320: Rockstars of USAMRIID01:15:05

TWiM travels to the U.S. Army Medical Research Institute of Infectious Diseases to learn how research conducted at USAMRIID leads to vaccines, drugs, diagnostics, and training programs that protect both warfighters and civilians.

Hosts: Michael Schmidt, Petra Levin and Michele Swanson.

Guests: Norman Kreiselmeir, Christopher K Coat, Keersten Ricks, and Eric Nguyen

Links for this episode:

Become a patron of TWiM.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

28 Jun 2019199: PhD Balance01:15:16

From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review.

Hosts: Vincent Racaniello, Michele Swansonand Michael Schmidt

Guests: Susanna L. Harrisand Alex Politis

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 

07 May 2021241: What Does Flu Do to Your Poo?01:04:01

TWiM explains how Vibrio biofilms are dispersed by polyamine signals, and the induction of inappetence by respiratory virus infection which causes alteration of the gut microbiome.

Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email.

Become a patron of TWiM.

Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 

20 Jan 2024302: Itching and Scratching and New Antibiotics00:54:33

TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter.

 

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Links:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

 

23 Oct 2020228: Black in Microbiology with Ninecia Scott and Chelsey Spriggs00:53:14

Ninecia and Chelsey, two of the founders of Black in Microbiology, join TWiM to discuss the goals of the organization, then we reveal survival of Deinococcus bacteria for 3 years in space, an experiment that addresses the panspermia hypothesis for interplanetary transfer of life.

Guests:  Ninecia Scott and Chelsey Spriggs

You can watch this episode at https://youtu.be/1o1hh0I4rio

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.

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Links for this episode

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 

22 Jun 2021244: Chewing for chicha00:56:49

Foodie TWiM reveals that bacteria in human saliva are major components of Ecuadorian indigenous beers, and an unusual E. coli that produces atypical light cream-colored colonies in chromogenic agar.

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Links for this episode:

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

08 Sep 2016TWiM #134: Lipids that live forever01:04:23

Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 

07 Oct 2016TWiM #136: Diderms and then monoderms00:48:43

Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 

26 Jul 2018181: Dr. Warhol’s Periodic Table of Microbes00:58:01

Vincent speaks with John Warhol about state microbes, the Periodic Table of the Microbes, and why microbiology is cooler than astrophysics, but they have better TV shows.

Host: Vincent Racaniello

Guest: John Warhol

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11 Apr 2025330: More mouth Microbiology00:53:57

TWiM explains how to recode E. coli so it uses only one stop codon, and an exploration of the mechanisms of bacterial adhesion within dental plaque.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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16 Nov 2017TWiM #164: Indiana Quorum00:59:10

From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria.

Guests: Ankur Dalia, Julia Van Kessel, and Xindan Wang

Watch the video version! https://www.youtube.com/watch?v=ifGCe-qfnA0

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24 Dec 2020232: Microbial nanowires00:55:32

TWiM explores the use of a bacterial protein to make highly conductive microbial nanowires, and how modulin proteins seed the formation of amyloid, a key component of S. aureus biofilms.

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27 Feb 2013TWiM #51: Cave science with Hazel Barton01:18:41

Vincent, Michael, and Elio meet up with Hazel Barton to talk about cave microbiology.

13 Feb 2014TWiM #72: The benefits of virulence 01:14:10

Vincent, Elio, Michael, and Michele review how microbial virulence can be increased as a consequence of community surveillance and adaptation to macrophages.

 
11 Aug 2023292: Breast Milk Bioactives00:58:47

TWiM reveals that breast milk bioactives are essential for development of the infant microbiome and immunity, and how capsule mutants of Klebsiella pneumoniae can affect bacterial pathogenesis.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,

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07 Jan 2022257: I have one word for you: plastics01:01:19

On this episode of TWiM, how phages prevent other phages from invading their hosts without blocking their own reproduction, and plastic-degrading potential of microbes across the Earth.

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24 Jun 2015TWiM #106: Lawn mower disease01:16:32

 

Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against Franciscella tularensis, the causative agent of tularemia.

24 Jul 2014TWiM #83: Illuminating tuberculosis and cryptococcosis01:19:09

Vincent, Michael, Elio and Michele review a new fluorogenic diagnostic test for tuberculosis bacteria, and the role of a metalloprotease in helping a fungus invade the central nervous system. 

 
20 Oct 2016TWiM #137: The battle for oxygen01:08:54

Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.

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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 

23 Mar 2011TWiM #3: Anthrax, genomics and the FBI inquiry01:00:27

Vincent, Jo, Cliff, and Ron explore the genome analysis done in support of the Amerithrax investigation, and an insecticidal enterotoxin-deficient mutant of Bacillus thurigiensis.

22 Dec 2017TWiM #167: I have one word for you: Flink00:52:40

How pandemic influenza viruses suppress immunogenic cell death, and 3D printing of bacteria into functional materials.

04 Apr 2012TWiM #30: Unraveling melioidosis and insulin resistance01:10:04

On episode #30 of the podcast, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor.

23 Jun 2016TWiM #130: Interkingdom interactions at ASM Microbe01:17:28

Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.

02 Nov 2017TWiM #163: Saliva and sptR/S01:06:17

This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation.

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29 Jul 2023291: Biogeography of Tectonics and Teeth01:01:11

TWiM explains how photoferrotrophic bacteria initiated plate tectonics over 2500 million years ago, and how two bacteria work together to cause childhood tooth decay.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin,

Guest: Mark O. Martin

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28 Mar 2021238: Parkinson’s disease gut microbiome00:56:53

Elio reveals his thoughts on the big themes of modern microbiology, followed by an analysis of the gut microbiome in patients with Parkinson’s disease.

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28 Oct 2021253: Cell growth and cell size with Petra Levin01:03:26

Petra Levin joins TWiM to tell three stories from her laboratory: how starvation induces shrinkage of the bacterial cytoplasm; plasticity of E. coli cell wall and how it influences antibiotic resistance across different environments; and induction of antibiotic resistance by Triclosan.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt

Guest: Petra Levin

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05 Oct 2011TWiM #17: Debugging endosymbiosis 01:10:31

Vincent, Michael, and Elio focus on endosymbiosis: the rapid spread of Ricekttsia in whitefiles, and a metabolic patchwork in nested symbionts of mealybugs.

30 Nov 2017TWiM #165: Pumping Copper01:03:19

The TWiM team discusses the use of copper on exercise weights to reduce bacterial burden, and the mechanism of antigenic variation by which a fungus that causes severe pneumonia escapes the immune system.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson

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31 Oct 2018188: Turducken antibiotics01:20:45

The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome.

Hosts: Vincent Racaniello and Michael Schmidt

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13 Oct 2020227: The light and dark sides of the fungal world00:48:11

TWiM presents an episode for mycophiles: how bacteria disarm mushroom pathogens, and the role of the CARD9 protein in protective immunity against pulmonary cryptococcosis.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt and Michele Swanson

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01 Dec 2016TWiM 140: Small town, big science01:20:13

Host: Vincent Racaniello

Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel

At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about how Rocky Mountain Laboratories influenced school science programs and opened up career opportunities.

 

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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

25 Jan 2012TWiM #25: Magnetotactic bacteria and totally drug resistant TB01:16:55

On episode #25 of the podcast, Vincent, Elio, and Michael review bacteria that use the earth’s magnetic field for navigation, and identification of totally drug resistant Mycobacterium tuberculosis.

21 Jan 2015TWiM #96: A lean, mean sequencing machine00:54:39

Hosts: Vincent Racaniello.

Special guest: Rob Knight

Vincent meets up with Rob Knight to talk about the technology that has fueled his drive to sequence the Earth and its inhabitants.

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Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

09 Aug 2022270: Magnets and Salt Improve Plastics Production by Archaea00:52:32

TWiM explores the use of Archaea to produce plastics from molasses wastewater, and a bacterial defense against bacteriophage infection that involves depletion of deoxynucleotides.

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14 Nov 2019209: Resuscitating persisters and flagellotrophic phage00:58:18

The TWiM team reveals how ribosome modification resuscitates bacterial persister cells, and explain how a phage tail fiber protein exploits rotation of flagella to move towards the cell membrane.

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06 Aug 2015TWiM #109: Precision killing01:08:52

The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts.

 

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Image: Transmission electron micrograph of Wolbachia within an insect cell.

By: Scott O'Neill - Genome Sequence of the Intracellular Bacterium Wolbachia. PLoS Biol 2/3/2004: e76.

22 Feb 2012TWiM #27: An inflamed gut is good for Salmonella01:14:31

Vincent, Elio, and Michael review how inflammation allows Salmonella to compete with fermenting gut microbes, and a riboswitch in bacterial and Archeal species that is triggered by fluoride.

11 Mar 2013TWiM #52: Clinical microbiology with Ellen Jo Baron01:00:27
Vincent and Michael meet up with Ellen Jo Baron to talk about working in a clinical microbiology laboratory.
18 Mar 2022261: Overwhelming Microbial Greatness01:19:36

Mark returns to TWiM to join in a discussion of soil microbiota as game-changers in restoration of degraded lands, and discovery of a centimeter-long bacterium, the biggest yet discovered.

Guest: Mark O. Martin

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22 Sep 2023295: Uncultured and Unmutable01:06:48

TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target.

Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin,

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06 Sep 2019204: Programmable bacteria for antitumor immunity01:07:46

Host: Vincent Racaniello

Guests: Nicholas Arpaia and Tal Danino

Vincent meets up with Nick and Tal to explain how they engineered E. coli to lyse within tumors and deliver an antibody that causes tumor regression in mice.

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23 Feb 2011TWiM #1: Neisseria LINEs up01:03:23

On episode #1 of the podcast This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact.

01 Jan 2016TWiM #118: Spore-drops keep fallin’ on my head01:05:35

Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson

On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers.

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This episode is sponsored by ASM Microbe 2016 and ASM Biodefense

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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02 Dec 2015TWiM #116: Chewates and coconuts01:00:58

Hosts: Vincent RacanielloElio Schaechter and Michele Swanson

The TWiMeriti reveal a Brazilian social bee that must cultivate a fungus to survive, and diet-mediated reduction in gut colonization by Candida albicans.

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This episode is sponsored by ASM Biodefense and the 32nd Clinical Virology Symposium.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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10 Mar 2023282: At-home evolution with yeast00:54:03

TWiM presents a protocol for evolving caffeine-tolerant yeast by high school students in the home, and how predator-prey dynamics change when multiple bacteria grow together in biofilms.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin.

Guest: Mark O. Martin

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17 May 2018176: Elio has lots of colanic acid00:59:48

Vincent, Michael and Elio note the passing of Stanley Falkow, give E. coli an archaeal membrane, and show how the microbiome can make worms live longer.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

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30 Mar 2018173: Gee whiz in style00:58:34

The Masters of the Microbiological Universe discuss the humongouest fungus, and a commensal bacterium that protects against skin neoplasia.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

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02 Oct 2021251: Biofilms, Coronaviruses, and a Shigella Vaccine00:57:09

TWiM explores the role of biofilms in infection by coronaviruses, and development of a Shigella vaccine using outer membrane vesicles derived from Salmonella

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03 Feb 2024303: Can Our Microbiome Break Our Hearts?00:56:32

TWiM reveals a database of genome sequences of thousands of Mycobaterium tuberculosis, allowing association with resistance phenotypes to 13 antibiotics, and microbe-derived uremic solutes that enhance thrombosis potential in the host.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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14 Jun 2017TWiM #154: Rigor, lotteries, and moonshots01:14:22

At Microbe 2017 in New Orleans, the TWiM team speaks with Arturo Casadevall about his thoughts on the pathogenic potential of a microbe, rigorous science, funding by lottery, and moonshot science.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Watch the video version recorded live at ASM Microbe 2017!

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16 Jul 2020221: Weapon of mucus destruction, WMD01:08:47

TWiM reveals a potential mucus-busting weapon for patients with cystic fibrosis, and bacteria in the intestinal tract that can oxidize cholesterol, leading to lower levels of the lipid in blood.

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15 Jun 2018178: Corals are sexy with Christina Kellogg01:04:48

The TWiM team travels to ASM Microbe 2018 in Atlanta, Georgia to speak with Christina Kellogg about her career and her research on coral microbial ecology.

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson

Guest: Christina Kellogg

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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21 Sep 2018185: There’s no moa Moa01:08:22

The TWiM team considers the increasing tolerance of Enterococcus to handwash alcohols, and how the study of DNA in ancient dung reveals the diet and parasite burden of extinct New Zealand birds.

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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08 Nov 2024321: The Microbes in Your Food01:00:03

TWiM focuses on recent foodborne outbreaks of bacterial infections, and how nanopore sequencing technology can be used to identify pathogenic microbes and antimicrobial resistance genes in food products.

Hosts: Vincent Racaniello, Michael Schmidt, Petra Levin and Michele Swanson.

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