The Science of Everything Podcast (James Fodor)

The first in a two-part episode covering the circulatory and respiratory systems, including a discussion of the anatomy of the heart, the process of contraction, and the generation and propagation of electrical activity. I also discuss how the heart functions as a pump, the various types of blood vessels, and control of the heart rate by the brain. Recommended pre-listening is Episode 25: Tissues, Organs and Systems, and Episode 26: Human Organ Systems.

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Our climate change series concludes with a discussion of the various lines of evidence indicating that recent warming is the result of human-produced greenhouse gases, including greater warming at night, cooling of the stratosphere, and relative depletion of C14 in the atmosphere. We then consider the various expected impacts of climate change, including increased extreme weather events, acidification of the oceans, changes to crop yields, and affects on various ecosystems. We end with an analysis of the relative costs and benefits of mitigation, and discuss likjely climate projections for the remainder of the 21st century. Recommended pre-listening is Episode 143: Climate Modelling.

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I introduce the unique and diverse chemistry of the transition metal elements, also known as the d-block metals. I begin with an overview of transition metal properties and ores, and then discuss coordination complexes, ligands, denticity, chelation, coordination geometries, isomerism, and the difference between strong and weak field ligands. We then examine how crystal field theory can explain many properties of transition metals, including their unique colouration and magnetic properties. The episode concludes with an overview of organometallic compounds and ligand field theory, including how pi-bonding can explain the difference between strong and weak field ligands.

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An exploration into the exciting world of home appliances and devices. We begin with a journey through the kitchen, discussing the design and operating principles behind the refrigerator, rice cooker, convection oven, microwave, and dishwasher. We proceed to the laundry to examine how the washing machine, vacuum cleaner, clothes iron, and dryer work. Finally we take a bathroom break and consider how the flush toilet, sinks, and plumbing work. 

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In the second part of our series on economic growth and development, I provide a brief history of the world economy, beginning with the key features of premodern economies and the Malthusian trap. I then outline critical developments and points of debate in subsequent economic history, including the Great Divergence, the First and Second Industrial Revolutions, the Great Depression and era of central planning, the Bretton Woods era and the gold standard, and the modern period of neoliberalism and globalisation. Recommended pre-listening is Episode 103: Economic Growth and Development Part I.

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Building on the previous discussion of Hartree-Fock Theory, I discuss the inclusion of basis functions to produce the Roothaan equations, and the method of solving these using self-consistent field methods. I then provide an introduction into techniques to incorporate electron correlation by adding Slater determinants, focusing on the Configuration Interaction method. I then provide a brief overview of semi-empirical methods, Density Functional Theory, and molecular mechanics. Recommended pre-listening is Episode 119: Computational Chemistry Part 1.

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An overview of the underlying mechanisms of pain, including the role of nociception, transduction of nociceptor signals by spinal pathways, the modulatory effects of opioids, and processing of these inputs in the brain. I also discuss phenomena such as referred pain, psychogenic pain, and congenital insensitivity to pain.

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A discussion of the metabolic pathways involved in breaking down proteins, carbohydrates, and lipids into simple components, extracting their energy, and building back up into more complex components needed for bodily function. We cover glycolysis, the citric acid cycle, lipolysis, beta oxidation, amino acid deamination, gluconeogenesis, fatty acid synthesis, and amino acid synthesis. Our overall focus is on the central role of acetyl-CoA and how the different metabolic pathways interact and intersect. Recommended pre-listening is Episode 18: Biochemistry Basics and Episode 75: Cellular Respiration.

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A discussion of the effect of wind on landscapes, focusing on deserts and coastlines. I outline the processes of eolian erosion, transportation, and deposition occurring in deserts, with particular focus on the formation and types of sand dunes. I also discuss other desert landforms, such as the desert pavement, mesas, and alluvial fans. I conclude with a look at coastal processes, including cliff erosion, emergent and submergent coastlines, and beach erosion processes.

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Building on the basic concepts discussed in the previous episode, this episode examines the formation and development of a wide range of weather phenomena, including air fronts, midlatitude cyclones, tropical cyclones, thunderstorms, and tornadoes. Recommended pre-listening is Episode 109: Weather Part I.

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The first in a new series on geomorphology, in which I review the main erosion processes that shape landforms of the natural environment. Here I discuss the key mechanisms of physical and chemical weathering, outline the major forms of erosion, and provide an overview of mass wasting including rockslides and soil creep. I then present an overview of stream processes, including a discussion of river drainage systems, channel patterns, meandering streams, and stream loads. Recommended pre-listening is Episode 75: Rocks and Minerals.

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An introduction to the processes by which cells control which genes are expressed. We begin with an overview of why genetic regulation is necessary and the key stages where such regulation occurs, including key concepts such as transcription factors and DNA binding domains. We then discuss prokaryotic gene regulation, focusing on the lac operon in E. coli. We then expand the discussion to cover the various mechanisms of eukaryotic gene regulation, including chromatic remodelling, transcriptional regulation, post-transcriptional regulation, RNA editing, and micro RNAs. Recommended pre-listening is Episodes 34-35: DNA Structure and Function, and Episode 118: Cell Signalling.

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An introduction to human nutrition, in which we discuss the nutritional importance and role of carbohydrates, fats, proteins, vitamins, and minerals, before considering the effects of malnutrition, how it is measured, and its prevalence around the world. We conclude with an analysis of basal metabolic rate, reviewing evidence concerning its variability across persons and factors that affect it. Recommended pre-listening is Episode 18: Biochemistry Basics

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In this fourth part of our series on economic growth and development, I outline the major theories of economic development developed over the past sixty years. I trace the development of such theories beginning with the Harrod-Domar theory, and proceeding through the Solow-Swan model, the Ramsey model, Romer's spillovers model, and endogenous growth theory, in each case discussing their key features, and analysing their strengths and weaknesses. The episode concludes with a brief survey of a range of more recent growth models focusing on modelling coordination failures and poverty traps, emphasising the work of Daron Acemoglu on economic institutions. The Recommended pre-listening is Episode 105: Economic Growth and Development Part III.

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I discuss the mysterious phenomenon of sleep, outlining the different stages of sleep, how the brain controls sleep and wakefulness, and the various theories for the functions of sleep. I also consider sleep in animals, the effects of sleep deprivation, and some major sleep disorders. Recommended pre-listening is Episode 38: Neurons and Synapses.

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An overview of the natural mechanisms by which climate changes over time. Beginning with an introduction to the concepts of radiative forcing and climate sensitivity, we then discuss solar forcing, orbital changes, volcanic eruptions, and silicate weathering, covering how each process operates and the effects it has on Earth's climate over varying periods of time. Recommended pre-listening is Episode 140: A History of Earth's Climate.

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Astrophysicist Mario Livio joins me to discuss his latest book 'Galileo and the Science Deniers', which chronicles the scientific discoveries of Galileo Galilei and how his advocacy of the heliocentric theory led him into confrontation with the Pope. Our conversation covers the significance of Galileo's discovers, the strengths and weaknesses of his case for the heliocentric theory, his role in establishing the modern scientific method, and what we can learn from this episode in history about the importance of intellectual freedom and science communication in the present day.

Check out Mario's book on Amazon.

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A journey through the history of Earth's changing climate, in which we explore how Earth's climate has fluctuated over the past billion years. After reviewing the various temperature proxies used to estimate past climactic conditions, we discuss the varying hothouse and icehouse periods of Earth's history, the onset of the Quarternay Ice Age, the current interglacial period, the anomoly of the Younger Dryas, the Medieval Warm Period and Little Ice Ages, and the rapid rise in temperatures during the twentieth century. Recommended pre-listening is Episode 90: Climate Systems.

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In this special collaboration with I Know Dino podcast, we discuss the history and impact of dinosaurs in popular culture and media. We cover the history of the scientific study of dinosaurs and how their presentation in media has changed over time with new discoveries, and what aspects of their behaviour and appearance tend to be presented accuracy or inaccurately. We also discuss lesser-known aspects of understanding dinosaurs, such as how changes in the atmosphere and ecosystem would affect dinosaurs of they were to be alive today.

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An introduction to the cell membrane, including a discussion of the structure of the bilipid membrane, an overview of the structure and function of membrane proteins, a review of the fluid mosaic model, and a discussion of mechanisms of membrane transport, including both passive and active transport. Recommended pre-listening is Episode 10: The Cell, and Episode 18: Biochemistry Basics.

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An introduction to the psychological study of personality, beginning with a definition of what is and is not personality and a brief history of the development of the field from Freud and Jung through the Myers-Briggs Indicator and the modern trait theories. I then discuss the Big Five personality traits, covering openness, conscientiousness, extraversion, agreeableness, and neuroticism, along with validation and criticisms of this model. I conclude with a brief discussion of values and narrative identity as additional aspects of personality. 

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In this the first in an eight-part series covering the causes of economic growth and development, I provide an introduction to the key concepts of absolute and relative poverty, different theories of development, and how GDP is defined and measured. I also discuss the differences between rural and urban poverty, give an overview of the different levels of development of various countries around the world, and outline some of the major methodological challenges in studying causes of economic growth around the world. Recommended pre-listening is Episode 12: The Price System, and Episode 56: The Gains from Trade.

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A journey through the complex network of regions controlling the human motor system, beginning with the spinal cord and its central pattern generators, and working up through the primary motor cortex, the premotor cortex, the posterior parietal cortex, the cerebellum, and the basal ganglia. I discuss the computational roles of each part of the motor control hierarchy, focusing on what functions are performed and what information is represented in each unique brain region. Overall I emphasise the complex interaction between top-down and bottom-up feedback in controlling muscle movement and executing complex motor tasks. Recommended pre-listening is Episode 132: The Muscular System, and Episode 38: Neurons and Synapses.

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An introduction to hormones and the endocrine system, including a discussion of the definition of hormones and their production, storage, release, and mechanisms of action. I also consider the mechanisms of control and regulation of hormone production, focusing on the role of the hippocampus and the pituitary gland. I conclude with an overview of major endocrine glands in the human body, including the gonads, adrenal glands, thyroid gland, and the thymus. Recommended pre-listening is Episode 38: Neurons and Synapses.

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Continuing the discussion of photosynthesis from the previous episode, here I outline the importance of the oxygen evolving complex in oxidising water molecules, the importance of photosystem I in extracting additional energy, and the role of light-independent reactions of the Calvin cycle in carrying out carbon fixation. Recommended pre-listening is Episode 101: Photosynthesis Part I.

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In this special episode I discuss genetic testing with Kira Dineen from DNA Today. We cover a range of topics including the process and science behind genetic testing, the types of genetic conditions that can be tested for, the difference between genotyping and gene sequencing, and the promises and potential issues with direct to consumer genetic testing. We also discuss developing social practises surrounding the use of gene technology, difficulties of informed concept, use of genetic material for criminal justice and ancestry databases, and potential future developments of these technologies. 

Link to Kira's podcast:

DNA Today (dnapodcast.com)

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An overview of climate models, beginning with a summary of the major types of models, and then a more detailed disussion of hte primitive equations and parameterised feedbacks that characterise the widely used Atmospheric General Circulation Models. We also discuss techniques for model validation and some evidence regarding the accuracy of various climate models. Recommended pre-listening is Episode 142: The Greenhouse Effect.

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In this third part of the series on economic growth, I discuss the process of structural change as economies progress from underdeveloped to developed, beginning with an overview and historical analysis of Rostow's Stages of Growth model. I then discuss the structures of agricultural production around the world, focusing on barriers to adoption of more modern agricultural techniques and proposed reforms, such as adoption of cash crops, land reform, and improving the security of land tenure. I conclude with an analysis of the benefits and problems associated with urbanisation, incorporating a discussion of agglomeration economies, spillover effects, urban gigantism, and the informal urban sector. Recommended pre-listening is Episode 104: Economic Growth and Development Part II.

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A discussion of the awesome power of volcanoes, including an overview of the different types of volcanoes, types of lava and pyroclastics, mechanisms of volcanic eruptions, a curvey of volcanic landforms, and a review of some major historical eruptions and their effects on Earth's climate. Recommended pre-listening is Episode 111: Plate Tectonics.

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In this fifth part of our series on economic growth and development, I examine the major factors that have been advanced as explaining differences in growth outcomes between countries. I provide a summary of the arguments and evidence for and against the importance of culture, dependency, democracy, geography, education, and institutions in accounting for differential growth outcomes, and conclude with a comparative empirical analysis in which I argue that institutional differences explain the majority of growth differences. The Recommended pre-listening is Episode 106: Economic Growth and Development Part IV.

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A detailed discussion of the greenhouse effect and its impact on Earth's climate. We begin with a discussion of Earth’s energy budget, the various greenhouse gases and their interactions with longwave radiation, and a summary of major sources of greenhouse gas emisions. We then examine the mechanisms of the greenhouse effect in more detail using the idealised greenhouse model and radiative transfer models. We conclude with an analysis of the sensitivity of Earth's climate to changes in greenhouse gas concentrations, and how this interacts with the atmospheric lapse rate. Recommended prelistening is Episode 141: Natural Climate Change.

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In the second and final part of this series, I discuss the major consequences of special relativity, including the relativity of simultaneity, time dilation, length contraction, and mass-energy equivalence. I then provide an overview of some of the experimental tests of special relativity, and conclude with an analysis of some alleged paradoxes in relativity, including the twins paradox, and the ladder paradox. Recommended pre-listening is Episode 114: Special Relativity Part 1.

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An overview of the field of microbiology, beginning with a brief history of the discipline, and then proceeding through a summary of the structure and function of various microbial life forms, including protists, yeasts, bacteria, archaea, viruses, and prions. The episode concludes with a discussion of microbial growth and methods to reduce it. Recommended pre-listening is Episode 10: The Cell.

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A discussion of earthquakes, covering the elastic rebound theory of earthquake generation, the phenomena of deep and intraplate earthquakes, types of seismic waves, methods of earthquake detection, different ways in which earthquakes cause damage, and attempts at earthquake prediction. Recommended pre-listening is Episode 111: Plate Tectonics.

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Continuing our series on General Relativity, we discuss the derivation of the Schwarzschild metric as a vacuum solution to Einstein's Field Equations, and analyse the physical meaning of this solution, including the properties of the singularity, event horizon, and effects of time dilation and length compression. We then consider how solutions like the Schwarzschild metric yield testable predictions such as gravitational lensing and graviational redshift, which serve as important evidence in support of General Relativity. We conclude with a discussion about some of the more exotic aspects of black holes, including Hawking radiation, the no hair theorem, and the black hole information loss paradox. Recommended pre-listening is Episode 136: Introduction to General Relativity.

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In this special celebratory 100th episode, I discuss six major unsolved problems in science: the P vs NP problem in computer science, the mystery of dark matter in physics, the existence of the island of stability in chemistry, the historical occurrence of a snowball Earth scenario from geology, the protein folding problem from biochemistry, and the origin of the Cambrian explosion in evolutionary biology. I also discuss some important ideas relating to the future of the podcast.

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Here we survey of the causes and consequences of genetic mutation, including a discussion of mechanisms of endogenous and induced mutations, rates of mutation, types of single nucleotide mutations, and the phenotypic effects of mutation. We also discuss various mechanisms for detecting and repairing genetic mutations, including base excision repair, DNA mismatch repair, nucleotide excision repair, double strand break repair. We conclude with an examination of large-scale chromosomal changes, including deletions, duplications, inversions, and translocations, unequal crossing over, with a brief look at polypoidy in plants and aneuploidy in humans. Recommended pre-listening is Episodes 34 and 35: DNA Structure and Function, and Episode 44: Cell Division.

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An overview of techniques of determining molecular structure, including an introduction to valance bond theory covering bond formation and orbital hybridisation, and a discussion of the basics of molecular orbital theory, covering the basics of the Hartree-Fock method for solving the Schrödinger equation and finding molecular orbitals. In the process I also discuss the Pauli exclusion principle, the effect of electron spin, and the indistinguishability of electrons.

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An introduction to the theory of plate tectonics, beginning with an overview of the internal structure of Earth, the differences between oceanic and continental crust, subduction and other forms of plate boundaries, the formation of volcanic arcs, the origin of the Earth's magnetic field, and the mechanisms underlying tectonic plate movement. The episode concludes with a summary of the varies lines of evidence in favour of continental drift, including seafloor spread, biogeography, and polar wandering. Recommended prelistening is Episode 74: Minerals and Rocks.

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An exploration of the role of the neurotransmitter serotonin in the development of depression. I discuss the role of serotonin in promoting the production of neurotrophic growth factor, the role the growth factor plays in facilitating neurogenesis and neural plasticity, and the various regions of the brain which are implicated in depression. I conclude by discussing the various cognitive distortions and other phenomena associated with depression, and how they can be treated by both pharmacotherapy and psychotherapy. Recommended pre-listening is Episode 38: Neurons and Synapses.

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An introduction to the conceptual and mathematical framework of Einstein's General Theory of Relativity. We begin by considering the key insight of gravity as a geometric phenomenon, and how the curvature of spacetime by matter explains the equality of inertial and gravitational mass. We then discuss the mathematics of general relativity, including geodesics, differential manifolds, covariant derivatives, the metric tensor, Christoffel symbols, the Riemann curvature tensor, the Ricci tensor, and the energy-momentum tensor. The episode concludes with a derivation and explanation of the significance of Einstein's Field Equations. Recommended pre-listening is Episodes 114 and 115: Special Relativity 1 and 2. 

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In this special episode I discuss various topics in evolution and genetics with Art Woods of the Big Biology Podcast. We begin by analysing various ideas associated with the extended evolutionary synthesis, including plasticity, epigentics, and niche construction, discussing the extent to which these ideas are a challenge or merely an addition to the mainstream understanding of evolution. We then consider several common misconceptions about genetics, including the idea of DNA as a blueprint and genetic essentialism. We conclude with a discussion of some politically contentious aspects of genetics.

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The first of a two part series on special relativity, I provide a brief overview of the historical development of relativity theory, including a discussion of the role of the Michelson-Morley experiment, and considerations from classical electromagnetism. I then outline Einstein's two postulates, discuss their meaning, and provide some explanation for how to interpret a constant speed of light. I also provide an introduction to Lorentz transformations and the notion of spacetime. Recommended pre-listening is Episode 13: Newtonian Mechanics.

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An overview of photosynthesis, including the structure of chloroplasts, phototransduction of energy by chlorophyll, the macromolecular complexes of the thylakoid membrane. I also discuss the mechanisms of electron transfer along the electron transport chain, and the role of ATP synthase in generating ATP. Recommended pre-listening is Episode 75: Cellular Respiration, Episode 32: Light and Optics, and Episode 18: Biochemistry Basics.

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A discussion of cell communication and signalling, including an overview of the purpose of cell signalling, the main types of signals, and applications such as hormones, neurotransmitters, and cytokines. The difference between G protein-coupled receptors, enzyme-linked receptors, and intracellular receptors is also considered, concluding with a summary of the process of signal transduction and the role of second messengers. Recommended pre-listening is Episode 116: The Cell Membrane.

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Concluding our series on geographic landforms, here I discuss glaciers, including their global distribution, formation, movement, and various glacial formations such as moraines, drumlins, and fjords. I also examine the role of ice in shaping periglacial landscapes, including the effects of permafrost and other frost action processes. I conclude with a brief discussion of groundwater, aquifers, and the hydrological cycle.

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An introduction to cryptography, internet security, and cryptocurrency, beginning with an overview of RSA cryptography and covering the use of public and private keys and their incorporation into the Transport Layer Security protocol used for secure internet communications. We then examine the key features of cryptocurrencies, including the blockchain, proof of work consensus mechanism, the use of hash functions, and the role of crypto mining. We conclude with a discussion of some of the advantages and disadvantages of cryptocurrencies, including their anonymity, volatility, use in crime, and environmental impacts.

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A discussion of the transportation and sorting of proteins within the eukaryotic cell, including an overview of the endomembrane system, the mechanisms of nuclear transport, transmembrane transport, and vesicular transport. I also consider the structure and functions of the endoplasmic reticulum, the Golgi apparatus, and lysosomes, and how they are joined together in a complex network of protein transportation and vesicular traffic. Recommended pre-listening is Episode 116: The Cell Membrane.

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An introduction to classical Mendelian genetics, in which we discuss Mendel's experiments with peas and the laws of heredity that he discovered, including inheritance of one allele from each parent, the law of dominance, and the law of independent segregation. We then consider more complex cases of genetic inheritance, including sex-linked traits, incomplete dominance, codominance, and epistasis. The episode concludes with a discussion of quantitative traits determined by many genes, including how genetic variation is described, how sources of variance are identified using genome wide association studies, and the conceptual issues with defining heredity and separating the effects of genes from those of environment.

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A special interview from the Padverb Podcast, in which I discuss my research on language in the brain and thoughts on AI. The discussion covers topics such as backpropagation, how humans acquire language and concepts, how artificial neural networks differ from biological neural networks, and some thoughts on the future impact of artificial intelligence. Near the end of the conversation, we also discuss some of my work on exploring the causes of economic growth and development.

Link to the Padverb Podcast: The Padverb Podcast with KMO on Apple Podcasts

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A review of the science between the metabolic syndrome, including discussion of obesity, diabetes, hypertension, and hyperlipidemia. We discuss the pathophysiology of how enlargement of adipocytes disrupts metabolic signalling pathways and leads to buildup of lipid intermediates. We then consider how these effects impair health, examining the causes of insulin resistance, atherosclerosis, and dysregulation of blood pressure. We conclude by looking at how such symptoms lead to pathology and increased mortality in overweight and obese individuals. Recommended prelistening is Episode 151: Diet and Nutrition, and Episode 18: Biochemistry Basics.

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An introduction to key concepts relevant to understanding weather, including relative and absolute humidity, atmospheric stability, cloud formation and classification, types of precipitation, and the formation and classification of air masses. Recommended pre-listening is Episode 90: Climate Systems.

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An introduction to the scientific study of emotion, including a discussion of the difficulties in defining emotions, discrete and dimensional methods of classifying emotions, the functional and representational roles of emotions, and an overview of major psychological theories of emotion, including the James-Lange and Cannon-Bard theories. We also examine the neurobiological basis of emotion, including the roles of the orbitofrontal cortex, the ventromedial prefrontal cortex, the cingulate cortex, and the amygdala. Recommended pre-listening is Episode 134: Hormones and the Endocrine System.

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Concluding the two-part series on the circulatory and respiratory systems, I discuss the biochemical mechanisms by which red blood cells and hemoglobin molecules deliver oxygen to the tissues and carbon dioxide to the lungs, and the mechanisms which regulate these processes. I then consider the respiratory system, giving an overview of the structure and function of the lungs, the process of breathing, control of breathing, and adaptations to high altitudes. Recommended pre-listening is Episode 122: Respiratory and Circulatory Systems Part 2.

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A discussion of the method of reproduction of flowering plants, including an overview of the structure and function of the different components of the flower, pollination, double fertilisation, and seed formation, dispersal, and germination. I also discuss the different types of fruit and vegetables and how the different components of the plant relate to the parts that we consume. I conclude with a brief overview of non-edible plant products, including fibres, resin, and sap. Recommended prerequisite is Episode 97: Plant Structure and Function.

A discussion of the shape of the Earth and the difficulties and conventions involved in describing a three-dimensional surface on a two-dimensional map, including an overview of some of the major map projections and their various limitations. This leads in to an overview of Earth's axial tilt and variation in solar insolation by latitude as an explanation for the seasonal variation in weather across the planet. Recommended pre-listening is Episode 87: The Geography of Planet Earth.

An overview of the composition and layers of the Earth's atmosphere, including a discussion of the exosphere, thermosphere, mesosphere, stratosphere, and troposphere. I also discuss the ozone layer and ozone depletion, the Karman line which marks the boundary of space, and the ionosphere. Recommended pre-listening is Episode 42: Gases and Gas Laws.

An analysis of the major factors influencing climactic variation over Earth's surface, including a discussion of the effect of differential heating at different latitudes, the impact of continentality and sea breezes, the causes of monsoons, the coriolis effect, atmospheric circulation cells, the jet streams, and thermohaline circulation currents in Earth's oceans. Recommended pre-listening is Episode 88: Cartography and Earths Seasons, and Episode 89: The Atmosphere.

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We begin our series discussing how computers work with an overview of the theory of computation, including a discussion of Turing machines and Turing completeness, and a brief history of early analog and digital computers. I also provide an introduction to the key components of a modern computer, and review the different levels in the hierarchy of computer organisation.

In this second episode in the series, I explain binary digital coding to motivate a discussion of the operation of transistors. Beginning with an examination of the properties of semiconductors and why they are useful for constructing transistors, I then examine how MOSFET transistors are constructed by combining pMOS and nMOS semiconductors.

In this third part of the series on computers I begin with an overview of Boolean algebra, including a discussion of key logic functions such as NOT, AND, and OR, and also discuss how CMOS logic gates implementing these functions are fabricated from transistors. I then survey the wide variety of logic components used in electronic circuits, including the multiplexor, adder, tristate buffer, flip-flops, comparator, and clock generator, and discuss the functions fulfilled by these devices in modern computers.

In this fourth part in our series on computers, I begin with an overview of the von Neumann architecture used in most modern computers. This leads in a discussion of the structure and operation of the central processing unit, covering the instruction register, the program counter, main memory, the data and address buses, the ALU, and the control Unit. I then discuss the purpose and implementation of a number of key operations in the instruction set architecture, including arithmetic operations, data movement operations, and conditional branches.

In this the fifth episode of the series 'how computers work', I begin with a summary of some of the major methods of improving the performance of the central processing unit, including pipelining, cache memory, branch prediction, and parallel processing. Following a brief introduction to assembly langague and its relationship to the machine code, I then discuss the operating system and how it interfaces with the hardware to manage program memory, system calls, input/output, and processes.

In the final episode of our series on computers, I give an introduction to high-level programming languages, how they relate to assembly language and machine code, and how the compiler converts high level programs into a form that can be executed by the processor. I then outline some of the key components to high-level programming, such as data structures, control structures, and algorithms, before sketching an example implementation of a simple game. I conclude with an integrative summary of computer structure from silicon up to the operating system.

An overview of the nature and properties of electromagnetic radiation, including a discussion of the electromagnetic spectrum, the nature of photons, the speed of light, near and far field radiation, and technological applications of electromagnetic radiation in AM and FM radiation and microwave ovens. Recommended pre-listening is Episode 61: Magnetism and Episode 57: Electric Current and Circuits.

An overview of the basic morphology and physiology of plants, including a discussion of the main types of plants, stems, roots, leaves, plant transport, meristems, plant nutrition, and plant sensory systems.

A journey through the digestive system, beginning with the mouth and progressing through the esophagus, stomach, small intestine, and large intestine, we consider the structure and function of all key components of the gastrointestinal tract and their roles in facilitating the metabolism of our food. We also discuss the contribution of accessory organs, including the liver, gall bladder, and pancreas. We conclude by considering a few myths about digestion. Recommended pre-listening is Episode 25: Tissues, Organs and Systems.

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In this sixth and final part in our series on economic growth and development, I discuss in more detail some of the key institutions necessary for economic growth to begin, focusing on property rights, enforcement of contracts, and control of corruption. I review the importance of these institutions in the context of historical case studies of countries ranging from the Soviet Union to Mexico, and outline how the most critical institutions vary with the level of development, giving rise to a middle income trap. I also discuss the Washington Consensus and critically analyse the arguments of critics that such institutional reform is not essential for growth. I conclude with a summary of all we have learned and discussed throughout the growth series. The recommended pre-listening is Episode 107: Economic Growth and Development Part V.

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A special episode in which I discuss some of the ideas and principles behind the production of the show, sources I use for episodes, and my motivations for starting the podcast. I also talk about my own background and research interests, my thoughts about the relationship between science and philosophy, and some ideas for the future of the Science of Everything Podcast.

A journey through the mechanisms of muscles and muscular contraction. I begin by outlining the key structural elements of muscle cells, including the sarcolemma, sarcoplasmic reticulum, the myofibrils and their myofilaments. I then explain the sliding filament mechanism of muscle contraction, and how it is governed by neural signals through the release of calcium. I conclude with a brief overview of the types of muscle contractions, the difference between fast twitch and slow twitch muscle fibres, and a short discussion of some metabolic aspects of muscle function, including the role of creatine phosphate. Recommended pre-listening is Episode 26: Human Organ Systems.

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A discussion of higher-order processing of information in the visual system, including an overview of how the brain extracts edges and basic shapes from simple stimuli in the retina, how motion is detected, how parts of objects are distinguished, how object recognition occurs, and the differences between grandmother cell and distributed processing theories of neural encoding. Recommended pre-listening is Episode 47: Vision Part III.

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I discuss the methods and results of my Master's Thesis, in which I analysed electrophysiological data of the mouse visual system using a variety of statistical and computational techniques. I consider some of the major research questions addressed in my work, including population encoding, stimulus representation, neural network modelling, and state space modelling of information transformation. Recommended pre-listening is Episode 113: Visual Processing.

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In this special episode I am joined by Jared Bauer, cofounder of Wisecrack, to discuss science and philosophy in movies and popular culture. We cover a range of topics including how science is portrayed in movies, how the film medium leads to science and history being presented in particular ways, and how movies and popular culture can be used as a vehicle for promoting scientific and philosophical inquiry.

An overview of the structure and function of the nervous system, including a discussion of the autonomic and somatic divisions of the peripheral nervous system, the spinal cord, and the brain. I discuss the major regions and structures of the brain, including the brainstem, the cerebellum, the cerebral cortex, and various subcortical structures. I conclude with some brief remarks about lateralization and the relationship between brain size and IQ.

A discussion of gravity, beginning with a history of the concept from the ancient Greeks though to Newton. Also includes an explain Newton’s universal law of gravitation, how orbits work, how astronauts experience gravity in space, and how gravity causes the tides.

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An overview of the structure and function of cells, as well as their discovery, size, and classifications. Organelles discussed include the nucleus, plasma membrane, endoplasmic reticulum, ribosomes, Golgi apparatus, and mitochondria. Also includes with a brief discussion of the unique properties of plant cells.

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An overview of the chaotic inflationary theory for the origin of the universe, including a discussion of the inflaton field, quantum fluctuations, spontaneous symmetry breaking, and the zero net energy of the universe. Also includes a discussion of multiverse theory and the fine-tuning paradox.

An examination of how the price system works, including an introduction to supply and demand theory, and the concepts of clearing the market and surplus maximisation. We also look at how the price system promotes efficiency helps to regulate economic activity. Also includes a discussion of how prices store and communicate economic information.

An introduction to basic Newtonian Physics, including a discussion of forces, velocity, acceleration, Newton’s three laws of motion, and some common misconceptions about forces. We also discuss circular motion and conclude with a brief look at the physics of walking and driving a car.

An introduction to the key principles of quantum mechanics, beginning with an examination of the quantum-mechanical description of the behaviour of electrons around atomic nuclei. This is followed by an overview of some of the other major principles of quantum theory, including the Heisenberg Uncertainty Principle, the Pauli Exclusion Principle, quantum tunnelling and entanglement. The episode concludes with a discussion of alternative interpretations of these quantum phenomena. Recommended pre-listening is Episode 8: The Atom.

An overview of how atoms bond together to form different chemical substances, including a discussion of the tree main types of bonds (covalent, ionic, and metallic), and the relationship of these bonding types to the concept of electronegativity. I also discuss the difference between polar and non-polar bonds, and conclude with some interesting applications of bonding theory to understanding the properties of materials.

A discussion of the importance of the profit motive and freedom of competition in the efficient operation of a market economy. Includes an overview of the uniformity of profit principle, and an examination of how competition serves as both an opportunity and a disciplining agent for entrepreneurs and firms, thus promoting useful innovations while weeding out bad ideas.

An overview of the basic concepts of linear momentum, angular momentum, work and energy. Includes a discussion of the conservation of momentum, why the concept is needed, and some applications of the concept to collisions and rotating objects. The nature of energy is also discussed, along with the different forms of energy, and how the concepts of energy and work are related.

An overview of biochemistry, covering the basic properties, structure and functions of nucleic acids, lipids, carbohydrates and proteins. Also includes a discussion of the nature of organic molecules and the importance of carbon in living organisms. Recommended pre-listening is Episode 15: Chemical Bonding.

A discussion of the principal circumstances in which markets do not produce an optimal outcome. After formally defining market failure, I discuss the ‘big four’ market failures of market power, externalities, public goods and asymmetric information. I conclude with a brief look at transaction costs. Recommended pre-listening is Episode 12: The Price System.

A discussion of the history of organic agriculture, the philosophy behind it, and the main methods used. Also includes a look at the environmental benefits of organic farming, including the effects on erosion, water pollution and biodiversity.

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An analysis of the various biases that effect the accuracy of human memory, including a discussion of spatial memory distortions, the impact of schema on memory, source monitoring failure, and the misinformation effect. I also discuss the interesting research regarding false memories, eyewitness memory, and flashbulb memories.

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An introduction to the basic concepts of biological evolution, including an overview of Charles Darwin’s contributions, a discussion of heredity, a summary of all the major evolutionary mechanisms, and a review of all the major lines of evidence supporting evolutionary theory.

A journey through Earth’s location in the universe, including a discussion of the Earth-moon system, the sun and planets of the solar system, nearby stars, the Milky Way Galaxy, the Local Group, clusters and superclusters, the large-scale structure of the universe, and speculations as to what may lie beyond.

An introduction to chemical reactions, including an overview of chemical equations, stoichiometry, thermochemistry, and reversible reactions. Also includes a discussion of collision theory to explain how and why chemical reactions occur.

An overview of the basic principles of wave phenomena, including a definition of waves, a discussion of wave mediums, wavelength, frequency and amplitude. I also discuss a variety of interesting wave behaviours including interference, polarization, resonance, reflection, absorption, refraction, diffraction and standing waves. This episode will form the foundation for later discussion of sound and light.

An overview of the various levels of biological organisation, from the atomic and molecular level through cells, tissues, organs, and up to populations and ecosystems. Also includes a more detailed examination of the structure and function of the four main types of human tissue, including epithelial, connective, muscle and nervous tissues.

A brief overview of all the human organ systems, including their major components and functions. Also includes an examination of how the organ systems work together to promote the proper functioning of the organism. Recommended pre-listening is Episode 25: Organs, Tissues and Systems.

An explanation of the forces and mechanisms of intermolecular bonding, including dispersion forces, dipole-dipole bonding and hydrogen bonds, with an application of these mechanisms in analysing surface tension. This is followed by a discussion of how phase transitions occur, focusing on evaporation, condensation, boiling and melting. Recommended pre-listening is Episode 15: Chemical Bonding.

A discussion of classical conditioning, including an analysis of its key components of the conditioned and unconditioned stimuli and responses, the acquisition process, extinction, recovery, generalization, and discrimination. I also discuss some applications of classical conditioning to understand a wide variety of behaviors, including taste aversion, drug tolerance, sexual fetishes, and emotional responses.

Continuing on from episode 28 on Classical Conditioning, in this episode I discuss another form of learning called Operant Conditioning, including the concepts of reinforcers, punishers, shaping, and schedules of reinforcement. I then apply Operant Conditioning theory to understand phenomena such as animal training and how punishments can be effectively used. The episode concludes with a brief look at a third form of learning, Observational Learning.

An examination of the perceived advantages of organic food in terms of safety, nutrition and taste, followed by a comparison of the costs and yield efficiencies of conventional versus organic farming techniques.

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An overview of the various forms of government that have existed throughout history and across the world, including a discussion of anarchy, democracy, monarchy, autocracy, and various forms of oligarchy, giving some key characteristics and important examples of each. Also includes an introduction to the principles of classification and political comparison.

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An analysis of liquids and their behaviour when mixed with other substances, incorporating a look at solutions, mixtures, colloids and suspensions. Special emphasis is placed on solutions, with a more detailed discussion of solubility, saturation, molarity and bubble formation.

A discussion of the nature of light and its interactions with matter, including a journey through the history of our understanding of light from Newton’s corpuscular theory through early wave theory and up to the modern wave-particle duality understanding. Following this is an analysis of the various ways light interacts with matter, including absorption, reflection, transmission, refraction, dispersion, and transparency.