The Peptide Podcast (The Peptide Queen)

In recent years, peptide therapies have garnered attention for their potential in addressing various health conditions, including weight management, hormonal imbalances, and chronic diseases. However, accessing these innovative treatments may require proactive advocacy, especially when discussing them with healthcare providers. Advocating for yourself to use peptide therapies in a healthcare provider's office involves open communication, collaboration, and persistence. 

In this podcast, we’ll talk about how you can be your own healthcare advocate for peptide therapy.

1. Educate Yourself

Before approaching your healthcare provider about peptide therapies, take the time to research and understand the specific peptides relevant to your condition. Familiarize yourself with how they work, potential benefits, risks, and any existing clinical evidence supporting their use. Reliable sources of information include peer-reviewed journals, reputable medical websites, and guidance from healthcare professionals specializing in peptide therapies.

2. Prepare for the Discussion

Gather relevant information and documentation to support your case for peptide therapy. This may include medical records, test results, and treatment histories related to your condition. Consider preparing a list of questions and concerns to discuss with your healthcare provider, focusing on how peptide therapies align with your treatment goals and preferences.

3. Initiate an Open Dialogue

Initiate a respectful and open dialogue with your healthcare provider about peptide therapies during a scheduled appointment. Clearly communicate your interest in exploring these treatment options and express your reasons for seeking them. Emphasize your commitment to actively participate in the treatment process and adhere to recommended guidelines.

4. Provide Evidence-Based Information

Present evidence-based information about peptide therapies to support your request. Share relevant research studies, clinical trials, or expert recommendations that demonstrate the efficacy and safety of these treatments in addressing your specific health concerns. Highlight any success stories or testimonials from individuals who have benefited from peptide therapies.

5. Address Concerns and Questions

Be prepared to address any concerns or questions your healthcare provider may have regarding peptide therapies. Listen attentively to their feedback and insights, and provide clarification or additional information as needed. Acknowledge any reservations or uncertainties while emphasizing your willingness to collaborate in exploring potential treatment options.

6. Collaborate on a Treatment Plan

Work collaboratively with your healthcare provider to develop a personalized treatment plan that incorporates peptide therapies, if appropriate. Discuss dosage, administration methods, monitoring protocols, and expected outcomes. Ensure that the treatment plan aligns with your individual needs, preferences, and medical history.

7. Advocate for Access

If your healthcare provider expresses reluctance or unfamiliarity with peptide therapies, advocate for access to specialized care or referral to a provider or peptide clinic with expertise in this area. Advocate for yourself by expressing the importance of exploring all available treatment options and ensuring equitable access to innovative therapies that may improve your health outcomes.

8. Follow Up and Monitor Progress

Maintain open communication with your healthcare provider throughout the treatment process. Follow up regularly to discuss any changes, concerns, or improvements in your condition. This can help your provider evaluate the effectiveness of the peptide therapy. It also helps them make adjustments to the treatment plan as needed based on ongoing assessments and feedback.

Remember that advocating for access to peptide therapies is an ongoing process that requires patience, persistence, and partnership with your healthcare team.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Glucagon-like peptide 1 (GLP-1) is a hormone primarily known for its role in regulating blood sugar levels through its effects on insulin secretion and appetite control. However, recent research has shown another significant function of GLP-1: its ability to reduce inflammation. This opens new avenues for therapeutic interventions in various inflammatory conditions and chronic diseases.

In this podcast, we’ll discuss GLP-1’s role in reducing inflammation and how it may help you.

What is GLP-1?

GLP-1 is an incretin hormone produced by intestinal L-cells in response to food intake. It enhances insulin secretion from the pancreas in a glucose-dependent manner. 

Here's how glucose-dependent insulin secretion works:

1. Increase in Blood Glucose Levels: After you eat, carbohydrates in your food are broken down into glucose, which is absorbed into your bloodstream, raising your blood sugar levels.

2. Release of GLP-1: In response to the rising blood glucose levels, your intestines release a hormone called GLP-1 (Glucagon-Like Peptide 1).

3. Stimulation of the Pancreas: GLP-1 travels through your bloodstream to your pancreas, where it stimulates the beta cells in the pancreas to release insulin.

4. Insulin Release: The insulin is then released into your bloodstream. Insulin acts like a key, allowing glucose to enter your cells so it can be used for energy.

5. Glucose-Dependent Nature: The important part is that this whole process depends on the presence of glucose. If your blood glucose levels are not high, GLP-1 will not signal your pancreas to release insulin. This prevents your blood sugar from dropping too low, which could cause hypoglycemia (dangerously low blood sugar levels).

GLP-1 also slows gastric emptying and reduces appetite, which collectively help manage postprandial blood glucose levels. GLP-1 exerts its effects by binding to the GLP-1 receptor (GLP-1R), which is expressed in multiple tissues, including the pancreas, brain, heart, and immune cells.

The Link Between GLP-1 and Inflammation

Inflammation is a complex response to harmful stimuli such as pathogens, damaged cells, or irritants. Chronic inflammation contributes to many diseases, including cardiovascular diseases, diabetes, and neurodegenerative disorders. 

How does GLP-1 reduce inflammation?

1. Modulation of Immune Cells: GLP-1 influences various immune cells, including macrophages, T cells, and dendritic cells. It has been observed to shift macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, reducing the secretion of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. This shift plays a crucial role in dampening the inflammatory response.

2. Inhibition of Nuclear Factor-kappa B (NF-κB) Pathway: NF-κB is a transcription factor that regulates the expression of genes involved in inflammation. Activation of GLP-1R has been shown to inhibit the NF-κB pathway, thereby reducing the transcription of pro-inflammatory genes. This inhibition helps in lowering the levels of inflammatory mediators in the body.

3. Reduction of Oxidative Stress: GLP-1 reduces oxidative stress by increasing the expression of antioxidant enzymes. Oxidative stress is a significant driver of inflammation, and by mitigating it, GLP-1 helps in lowering the inflammatory burden. This is particularly beneficial in conditions like atherosclerosis and diabetes, where oxidative stress is a major pathogenic factor.

4. Cardiovascular Protection: Chronic inflammation is a well-known risk factor for cardiovascular diseases. GLP-1 and its analogs have been shown to improve endothelial function, reduce vascular inflammation, and protect against atherosclerosis. These effects are mediated through the reduction of inflammatory cytokines and oxidative stress, as well as the improvement of lipid profiles.

5. Neuroprotection: Neuroinflammation is a critical component of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. GLP-1 analogs have demonstrated neuroprotective effects by reducing neuroinflammation, improving neuronal survival, and enhancing cognitive function. These benefits are attributed to the reduction in pro-inflammatory cytokines and the enhancement of neurotrophic factors.

Therapeutic Implications

The anti-inflammatory properties of GLP-1 have significant therapeutic implications. GLP-1 receptor agonists, initially developed for the treatment of type 2 diabetes, are now being explored for their potential in treating various inflammatory and chronic diseases.

1. Type 2 Diabetes and Metabolic Syndrome: The dual action of GLP-1 in regulating blood glucose and reducing inflammation makes it a promising therapeutic agent for managing type 2 diabetes and its complications.

2. Cardiovascular Diseases: Given the role of inflammation in atherosclerosis and other cardiovascular conditions, GLP-1 analogs could offer cardiovascular protection and improve outcomes in patients with heart disease.

3. Neurodegenerative Disorders: The neuroprotective and anti-inflammatory effects of GLP-1 analogs present a potential therapeutic strategy for slowing the progression of neurodegenerative diseases and improving cognitive function.

4. Inflammatory Bowel Disease (IBD): Preliminary studies suggest that GLP-1 analogs may help in reducing inflammation in IBD, offering a novel treatment approach for this chronic inflammatory condition.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

GLP-1 agonists, such as semaglutide (Wegovy), are popular medications for weight loss that work by mimicking the action of the GLP-1 hormone, which helps regulate appetite and blood sugar levels. While these medications can be very effective, some individuals might experience fluctuations in their appetite over time. If you've noticed that your appetite seems to be coming back even while on a GLP-1 agonist, you’re not alone. In this podcast, we’ll discuss why this might be happening and what you can do to manage it.

Why Appetite Might Return

1. Adaptation Over Time

   • Body Adaptation: As you continue with the medication, your body might adapt to the drug's effects. This adaptation can sometimes lead to a gradual decrease in the medication's effectiveness in controlling hunger.

   • Tolerance Development: Similar to other medications, the body can sometimes develop a tolerance, which may reduce the appetite-suppressing effects of GLP-1 agonists.

2. Dietary and Lifestyle Factors

   • Caloric Deficit: If you’ve been eating fewer calories, your body may signal hunger more strongly as it tries to maintain its energy balance.

   • Nutrient Imbalance: Eating a diet that's lacking in essential nutrients can lead to increased hunger and cravings.

   • Dehydration: Symptoms of mild dehydration, such as headache, fatigue, lightheadedness, and difficulty concentrating, can mimic those of hunger.

   • You’re not getting enough sleep: Sleep is closely connected to hormonal balance, especially hormones that control hunger and fullness. When you’re sleep-deprived, leptin, which signals that you're full, drops, making you feel hungrier and more prone to overeating. Meanwhile, ghrelin, the hormone that boosts appetite, increases with lack of sleep, intensifying cravings and contributing to weight gain.

3. Emotional and Psychological Factors

   • Stress and Emotional Eating: High stress or emotional challenges can lead to changes in appetite and eating patterns, sometimes overriding the effects of appetite-regulating medications.

4. Hormonal Fluctuations

   • Hormonal Changes: Your body is pretty smart. It knows what to do to maintain itself. When you lose weight and reach a new lower weight, your body might push back. This happens because of ghrelin, the “hunger hormone”. When you lose weight, levels of ghrelin go up, making you hungry again.

Tips to Help Stay Full Longer

1. Focus on Protein

   • Include Protein-Rich Foods: Protein can help keep you full longer by promoting satiety. Incorporate lean meats, beans, lentils, tofu, and Greek yogurt into your meals.

2. Eat Fiber-Rich Foods

   • Incorporate Fiber: Foods high in fiber, such as fruits, vegetables, whole grains, and legumes, can help you feel fuller for longer periods. Fiber slows down digestion and helps maintain stable blood sugar levels. But remember to start slow. Too much fiber can cause constipation.

3. Stay Hydrated

   • Drink Water: Sometimes thirst is mistaken for hunger. Drinking plenty of water throughout the day can help manage your appetite and prevent overeating. The general rule is to take your weight in pounds and divide the number in half. This is about how many ounces of water you should drink daily.

4. Monitor Portion Sizes

   • Control Portions: Eating smaller, balanced meals more frequently can help regulate hunger and prevent overeating. Be mindful of portion sizes and try to avoid large, infrequent meals.

5. Mindful Eating

   • Practice Mindfulness: Pay attention to your hunger cues and eat slowly. Mindful eating helps you recognize when you’re actually hungry and when you’ve had enough.

6. Regular Physical Activity

   • Exercise Regularly: Engaging in physical activity can help regulate your appetite and improve overall metabolism. Aim for a mix of cardiovascular, resistance, and flexibility exercises. This will help preserve lean muscle mass, which is important for maintaining a higher metabolic rate.

7. Manage Stress

   • Stress Reduction Techniques: To control emotional eating, incorporate stress-management practices into your routine, such as meditation, yoga, or deep-breathing exercises.

8. Consult with Your Healthcare Provider

   • Review Your Medication: If you’re consistently experiencing increased appetite despite following these strategies, discuss it with your healthcare provider. They might adjust your dosage or suggest an alternative treatment plan.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Did you know that you don't need a gym to enjoy the benefits of resistance training? You can do it right in the comfort of your home with no gym equipment, and it's fantastic for your overall health and heart health. Regular resistance training can improve your blood pressure, blood sugar, blood lipids, and body composition. It's especially helpful for older adults and those with a higher risk of heart problems (e.g., high blood pressure or cholesterol, diabetes, excess weight, current or former smokers, or a family history of heart disease).

In this podcast, we’ll discuss simple home workouts that you can do to help your overall health.

What is resistance training?

Resistance training, also known as strength training, involves exercises that improve muscular strength and endurance. This form of exercise typically uses resistance in the form of weights, resistance bands, or body weight to work specific muscle groups. By repeatedly challenging muscles, resistance training enhances their ability to generate force and sustain physical activity.

Benefits of Resistance Training

Cardiovascular and Overall Health

While resistance training primarily targets muscle strength and endurance, it also offers substantial cardiovascular benefits. Regular resistance training can:

• Improve heart health by reducing blood pressure and cholesterol levels.

• Help keep your arteries flexible and improves blood vessel function while lowering inflammation levels that typically lead to atherosclerosis (clogged arteries).

Keep in mind that while you may not notice these cardiovascular effects, you may experience noticeable improvements in your sleep and mood. 

Weight Loss and Muscle Mass

Resistance training is a powerful tool for weight loss and muscle mass maintenance. But how?

• Increased Metabolism: Building muscle boosts your resting metabolic rate, meaning you burn more calories even at rest.

• Fat Loss: While you may not see immediate weight loss, resistance training can help you lose fat and gain lean muscle, leading to a healthier body composition. 

• Muscle Preservation: During weight loss, preserving muscle mass is crucial. When people lose weight, they usually lose fat along with muscle mass. Given the popularity of GLP-1 agonists like semaglutide (Wegovy) and tirzepatide (Zepbound), it’s important to know that muscle wasting is a possible side effect of these medications. Resistance training ensures that most of the weight lost comes from fat, not muscle.

Keep in mind: Resistance training also promotes better body mechanics and posture, reducing the risk of injury and improving balance and coordination.

How to Get Started with Resistance Training

Getting started with resistance training can be intimidating, especially if you already don’t exercise or have mobility limitations due to arthritis, neurological conditions like multiple sclerosis, or obesity. 

You can always join a gym and meet with a personal trainer but we all know this is both costly and time-consuming. While in-person classes or training sessions might be motivating and fun, there is always the option of trying resistance training at home, on your own. You can find free exercise videos on YouTube or personal fitness blogs. 

1. Set Clear Goals: Determine what you want to achieve, whether it’s building muscle, losing or maintaining weight, or improving overall health.

2. Start with a Plan: Create a balanced workout plan that includes all major muscle groups (e.g., chest, shoulders, upper back, back and front of arms and legs, stomach, and lower back).

3. Learn Proper Technique: Proper form is important to prevent injuries. Consider working with a trainer initially or using reputable online resources. 

4. Start Light: To master the exercises, begin with lighter weights, then gradually increase the resistance as you become more comfortable and stronger. Start with shorter, lower-intensity sessions to help your body readjust and minimize the risk of injury.

5. Consistency: Consistency is key. Aim for at least two resistance training sessions per week. Each session should last 15 to 20 minutes and focus on 8 to 10 different exercises. 

Examples of Resistance Training Exercises

Here are some common resistance training exercises:

• Air squats, wall squats, and lunges: Target the legs and glutes. Specifically the front and back thigh and buttocks. No equipment is needed. 

• Deadlifts or upright rows engage the upper back muscles. Both can be done using long resistance bands instead of weights.

• Chest Press: This exercise works the chest, shoulders, and triceps. It can also be done without weights by doing push-ups, incline push-ups, or decline push-ups.

• Planks or abdominal crunch: Improve core strength and stability. No equipment is needed.

• Bicep Curls: Target the front upper arm. Again, if you don’t have weights at home, you can perform bicep curls using resistance bands.

• Calf raises: These target the calf muscle, and no gym equipment is needed. They can be done using stairs or a chair.

Remember to adjust the intensity and frequency of workouts based on your progress and fitness goals to ensure a safe and effective resistance training regimen.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

What is Metabolism?

Metabolism refers to the biochemical processes in which our bodies convert food and drink into energy. This energy is then used to fuel bodily functions such as breathing, circulating blood, and repairing cells. 

Metabolism is divided into two categories:

1. Catabolism: Catabolism is the set of metabolic pathways that break down molecules into smaller units to release energy. It involves the breakdown of complex molecules such as carbohydrates, fats, and proteins into simpler ones like glucose, fatty acids, and amino acids. This breakdown process releases energy, which is captured in the form of adenosine triphosphate (ATP), the primary energy carrier in cells. In simple terms, catabolism is the breakdown of molecules to obtain energy. 

2. Anabolism: Anabolism is the set of metabolic pathways that construct molecules from smaller units. These biosynthetic processes require energy, which is often derived from ATP produced during catabolic reactions. Anabolism is responsible for the growth and repair of tissues, the storage of energy, and the production of molecules necessary for cellular functions. In simple terms, anabolism is the synthesis of compounds needed by the cells.

How Does Metabolism Maintain Weight?

Our body weight is determined by the balance between the calories we consume and the calories we expend. Metabolism plays an important role in this balance:

• Basal Metabolic Rate (BMR): This is the amount of energy expended while at rest. It accounts for about 60-80% of daily calorie expenditure and includes the energy required for vital functions like breathing and keeping the heart beating.

• Thermic Effect of Food (TEF): This is the energy required for digestion, absorption, and removal of ingested nutrients. It accounts for about 10% of daily energy expenditure.

• Physical Activity: This includes all movements, from exercise to daily activities like walking or cleaning. It can vary greatly among individuals and is the most variable component of our energy expenditure.

What Happens to Our Metabolism When We Lose Weight?

When we lose weight, several changes occur in our metabolism:

Reduction in BMR:

• Loss of Lean Body Mass: During weight loss, especially if it’s rapid or involves severe calorie restriction, some of the weight loss can be from lean muscle mass. Since muscle tissue is more metabolically active than fat tissue, a decrease in muscle mass leads to a reduction in BMR.

• Smaller Body Size: A smaller body requires fewer calories to maintain. As you lose weight, your body mass decreases, and thus the energy required to sustain basic bodily functions also decreases.

Adaptive Thermogenesis:

• Metabolic Adaptation: The body responds to caloric restriction and weight loss by becoming more energy-efficient. This means that for a given level of activity, the body will burn fewer calories. This adaptive thermogenesis is believed to be a survival mechanism developed during periods of food scarcity in human history.

Decreased Energy Expenditure from Physical Activity:

• Reduced Body Mass: When you weigh less, the energy cost of physical activities decreases. For instance, walking or running requires less energy if you are lighter.

Why Steady Weight Loss is Better than Rapid Weight Loss

Steady, gradual weight loss is generally considered more effective and sustainable than rapid weight loss for several reasons we just mentioned:

1. Preservation of Lean Muscle Mass: Slow weight loss helps preserve lean muscle mass, which is crucial for maintaining a higher metabolic rate.

2. Sustainable Habits: Gradual weight loss encourages the development of healthy, sustainable habits rather than quick fixes that are difficult to maintain.

Also, keep in mind that rapid weight loss can lead to nutrient deficiencies, as it often involves restrictive diets that may lack essential nutrients. This can cause deficiencies that may impact overall health, energy levels, immune function, and more. It’s imperative that we focus on adequate intake of lean proteins, healthy fats, and complex carbohydrates in addition to vitamins and minerals to maintain our metabolism.

Also, slow, steady weight loss is associated with a lower risk of regaining the lost weight compared to rapid weight loss.

How GLP-1 Receptor Agonists Affect Metabolism

GLP-1 (glucagon-like peptide-1) receptor agonists, such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) help with weight loss and affect metabolism. They work by:

1. Increasing Insulin Secretion: GLP-1 agonists increase insulin secretion in response to meals, which helps regulate blood sugar levels.

2. Reducing Appetite: These medications help reduce appetite and increase feelings of satiety, leading to lower calorie intake.

3. Slowing Gastric Emptying: GLP-1 agonists slow the emptying of the stomach, which prolongs the feeling of fullness after eating.

When we lose weight, it can have both positive and negative effects on metabolism:

1. Positive Effects:

   • Improved insulin sensitivity

   • Lowered risk of chronic diseases such as diabetes, heart disease, and high blood pressure

Improved insulin sensitivity allows cells to more efficiently take up glucose from the bloodstream, which is then used for energy production. This process helps maintain stable energy levels throughout the day.

When insulin sensitivity is high, excess glucose is effectively stored as glycogen in the liver and muscles. This stored glycogen can be used during periods of increased energy demand, such as exercise.

Improved insulin sensitivity also helps keep blood sugar levels in check, preventing hyperglycemia (high blood sugar), which can damage blood vessels, nerves, and organs over time.

When cells respond well to insulin, the pancreas does not need to produce as much insulin to achieve the same effect. Lower insulin levels reduce the risk of developing insulin resistance and type 2 diabetes.

Lower insulin levels can also reduce fat accumulation and promote fat breakdown. Also, the body can more efficiently break down stored fats for energy, especially during periods of fasting or exercise.

Improved insulin sensitivity helps regulate hunger and satiety hormones, such as leptin. This regulation can lead to better appetite control and reduced cravings, supporting weight management efforts.

Efficient glucose uptake and utilization prevent the energy crashes and hunger pangs that can occur with insulin resistance, leading to more stable eating patterns.

Insulin is an anabolic hormone, meaning it promotes protein synthesis and muscle tissue growth. Improved insulin sensitivity enhances this effect, helping to maintain and build muscle mass, which is metabolically active and boosts overall metabolic rate.

Insulin resistance is associated with chronic low-grade inflammation, which can impair metabolic functions. Improved insulin sensitivity helps reduce inflammation, supporting better metabolic health.

2. Negative Effects:

   • Potential loss of lean muscle mass if weight loss is too rapid (decreases our BMR)

Ways to Boost Metabolism

While metabolism is largely determined by genetics, age, and sex, there are several ways to boost it:

1. Build Muscle: Engaging in strength training exercises helps build muscle mass, which can increase BMR.

2. Stay Active: Regular physical activity, including both aerobic and anaerobic exercises, helps burn calories and maintain a healthy weight.

3. Eat Protein-Rich Foods: Protein has a higher thermic effect compared to fats and carbohydrates, meaning it requires more energy to digest.

4. Stay Hydrated: Drinking water can temporarily boost metabolism, especially if the water is cold, as the body uses energy to heat it to body temperature.

5. Get Enough Sleep: Poor sleep can negatively affect metabolism and increase the risk of weight gain.

6. Manage Stress: Chronic stress can lead to hormonal imbalances that negatively affect metabolism and appetite.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Today we’re going to talk about something that could be a game-changer for anyone looking to support their eye health: Visoluten, the retinal bioregulator peptide. 

Bioregulator peptides like Visoluten are gaining attention in the field of regenerative medicine due to their ability to target specific organs or systems in a highly focused and natural way, supporting the body’s inherent healing processes.

So, whether you're someone who’s noticing some age-related vision changes, or you're just keen on taking better care of your eyes, stick around because this episode is for you.

What is Visoluten?

Let's start with the basics. So, what exactly is Visoluten?

Visoluten is a bioregulator peptide, specifically designed to support the health of the retina, the part of the eye responsible for turning light into signals that your brain interprets as vision. This peptide works by supporting metabolic processes in the eye tissues, promoting vision health and helping the eye adapt to extreme conditions—whether that’s stress from overuse, age-related changes, or environmental factors.

How Does Visoluten Work?

So, let’s talk about how Visoluten works. It’s all about regeneration and protection. The peptide supports the metabolic processes within the eye tissues, which helps maintain retinal function and protects the eye from oxidative stress and environmental damage. This is particularly important for maintaining visual health over time. It's a bit like giving your eyes the tools they need to keep themselves healthy, even under stressful conditions.

Visoluten also helps to improve blood circulation in the eye, which ensures that the retina receives all the necessary nutrients and oxygen to function optimally. For anyone dealing with conditions like age-related macular degeneration or diabetic retinopathy, this can be especially beneficial, as those conditions are often linked to poor blood flow and cellular damage.

Now, you may be wondering, where does Visoluten come from? Well, Visoluten is sourced from biologically active peptides extracted from the retina of calves or pigs. This sourcing ensures that the peptides are very similar to those found in the human retina, which makes them highly effective at interacting with human retinal cells.

What is a Typical Visoluten Dose?

When it comes to taking Visoluten, it’s typically available in capsules, with each capsule containing 10 milligrams of the active peptide. The typical dosage varies based on the condition being treated:

• For degenerative diseases like macular degeneration or diabetic retinopathy, the recommended dosage is 1 to 3 capsules, 2 to 3 times daily, for 15 to 30 days.

• For individuals using Visoluten preventatively or to support eye health, especially for those experiencing eye strain, the dosage is typically 1 capsule twice daily, for 15 to 30 days.

• For post-traumatic corneal dystrophy, the recommended dosage is 2 to 3 capsules, 2 to 3 times daily, for 15 to 30 days.

• Some people may choose to continue taking Visoluten long-term, particularly if they have chronic eye conditions or are using it for preventative purposes. 

• After completing a cycle, it is common for people to take a break (such as 1–2 months) before starting another 15 to 30 day cycle, especially for preventive use. 

• Visoluten capsules should be taken 30 minutes before meals to optimize absorption and effectiveness.

Who Shouldn't Take Visoluten?

Visoluten is generally considered safe for most individuals, but like any supplement, there are certain groups of people who should avoid taking it or take it with caution. Here's a breakdown of who shouldn't take Visoluten and potential allergies to watch out for:

1. Pregnant or Breastfeeding Women
   There is limited research on the safety of Visoluten during pregnancy or breastfeeding. As a precaution, it’s always best to avoid taking any supplement unless directed by a healthcare provider.
   
   

2. Individuals with Allergies to Ingredients:
   Since Visoluten is derived from animal sources (specifically the retina of calves or pigs), individuals who have allergies to bovine (cow) or porcine (pig) products may need to avoid it. If you know you have such allergies, you should consult with your doctor before taking Visoluten. Some Visoluten capsules may be made with gelatin, which is derived from animal collagen. If you are vegetarian, vegan, or have a gelatin allergy, this could be a concern. Look for vegetarian or non-gelatin capsules, if available.

3. Children:

Visoluten is typically intended for adult use, especially for conditions related to vision or age-related changes. Children under 18 should only take Visoluten under the guidance of a healthcare professional.

It’s also good to know that it’s well tolerated with no reported side effects or complications. 

Visoluten can be an important part of a comprehensive approach to eye health and could be especially useful for individuals looking to prevent or manage retinal conditions. Just remember, it’s always best to speak with a healthcare professional before starting any new supplement, especially if you have pre-existing conditions or are already on medication. They’ll help you determine the right dosage for your needs and ensure that it fits well into your health plan.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Sometimes, we need a little extra help battling weight and staying healthy. That's where semaglutide (Wegovy) comes in. It's more than just a weight-loss medication—it's a game-changer for long-term health. 

In this podcast, we'll discuss how semaglutide can help you beyond just shedding pounds and positively impact metabolic and cardiovascular health, quality of life, and longevity, among other things.

Metabolic Health: Semaglutide works with your body to help control your appetite and blood sugar levels. It does this by mimicking the action of glucagon-like peptide-1 (GLP-1), a hormone that regulates blood sugar levels and controls appetite. It also slows down how fast food leaves your gut, making you feel fuller after you eat.

By helping with weight loss, semaglutide improves insulin sensitivity, blood sugar control, and cholesterol levels. These improvements in metabolic health are important for reducing the risk of developing type 2 diabetes and cardiovascular disease.

Cardiovascular Health: Too much weight can stress your heart and blood vessels, leading to heart problems. But semaglutide can lower that risk. Not only can it help you lose weight, but it also improves your blood pressure and cholesterol levels and decreases inflammation. That's good news for your heart and overall health. But how does semaglutide do this?

1. Improving Heart Function: Semaglutide improves your heart by helping it pump blood more effectively. This means your heart can do its job without working too hard.

2. Reducing Inflammation: After a heart problem like a heart attack, inflammation can make things worse. Semaglutide can help decrease this swelling, which allows your heart to heal and prevents further damage.

3. Opening Up Blood Vessels: Semaglutide helps relax your blood vessels. When your blood vessels are relaxed, it's easier for blood to flow through them. This reduces strain on your heart and lowers the risk of high blood pressure-related complications.

4. Protecting Against Harmful Substances: Semaglutide acts like an antioxidant, helping protect your heart from damage caused by harmful substances in your body. 

5. Keeping Arteries Clear: Semaglutide helps prevent plaque buildup in your arteries. Plaque buildup can make it hard for blood to flow, increasing the risk of heart attacks and strokes. By keeping your arteries clear, semaglutide lowers your chances of having these serious heart problems.

Longevity: Most people want to live a long, healthy life. Semaglutide can help you achieve this by reducing the risk of serious health problems linked to obesity, like diabetes, heart disease, and certain cancers. You're setting yourself up for a healthier, longer future by taking care of your health now.

Enhanced Mental Well-being: Being overweight sometimes makes us feel down or stressed. Semaglutide can help lift that weight off your shoulders—literally. Losing weight and feeling better in your body will make you feel more positive and confident. It's not just about looking good; it's about feeling good, too.

Enhanced Mobility: Carrying extra weight can make it harder to move around and do the things you enjoy. But with semaglutide, you can lighten that load. As you shed pounds, you'll find it easier to get around and be active. That means more fun and fewer injuries and physical struggles in your everyday life.

Quality of Life: Feeling good in your body is important for enjoying life to the fullest. Semaglutide can help you do just that. By losing weight and feeling healthier, you'll have more energy to do the things you love, experience fewer aches and pains, and be able to participate in activities you enjoy. Plus, feeling better about yourself can boost your confidence and mood.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

What is SS-31? Ela-mep-ra-tide

SS-31, also known as Elamipretide, is a synthetic peptide that has gained attention in the scientific and medical communities for its potential role in treating various age-related and degenerative diseases. It is a small, mitochondria-targeting peptide specifically designed to protect and improve the function of mitochondria, the energy-producing "powerhouses" of our cells. 

Since mitochondrial dysfunction is linked to many chronic illnesses and the aging process, SS-31 has sparked interest in its potential to restore cellular energy and combat diseases at the cellular level.

In this podcast, we’ll discuss how SS-31 works and its potential benefits.

How Does SS-31 Work?

Mitochondria are essential for producing energy in cells through a process known as oxidative phosphorylation. During this process, mitochondria generate ATP, the primary energy source for most cellular functions. However, as we age or develop certain diseases, mitochondria can become less efficient, leading to oxidative stress and damage to cellular structures. This damage can result in various health issues, from muscle weakness to neurodegenerative diseases.

SS-31 directly interacts with cardiolipin, a key phospholipid in the inner mitochondrial membrane. Cardiolipin plays an essential role in maintaining mitochondrial structure and function. When mitochondria are stressed or damaged, cardiolipin can become dysfunctional. SS-31 binds to cardiolipin and helps stabilize it, protecting mitochondria from further damage. This stabilization improves mitochondrial efficiency, reduces oxidative stress, and enhances energy production.

Additionally, SS-31 helps reduce the production of reactive oxygen species (ROS), harmful molecules that can contribute to inflammation and cellular damage. By reducing oxidative stress, SS-31 may help prevent further damage to tissues and cells, slowing the progression of disease and the aging process.

Potential Benefits of SS-31

Research on SS-31 is still in the early stages, but some potential benefits of this peptide have been identified, particularly in the context of mitochondrial health and age-related diseases.

1. Improved Muscle Function

SS-31 has been shown to enhance muscle function, particularly in older adults or those with muscle-related diseases. By improving mitochondrial efficiency, SS-31 may help increase muscle strength and endurance, potentially benefiting conditions like sarcopenia (age-related muscle loss) and muscular dystrophies.

2. Neuroprotection

Since mitochondrial dysfunction is linked to neurodegenerative diseases such as Alzheimer's and Parkinson's, SS-31’s ability to stabilize mitochondria may offer neuroprotective effects. Early research suggests that SS-31 may help protect brain cells from oxidative damage and reduce inflammation, which could slow the progression of neurodegenerative diseases.

3. Cardiovascular Health

SS-31 may also have potential benefits for heart health. By protecting mitochondria in cardiac cells, SS-31 could help prevent damage to the heart and improve its function. Some studies have explored its role in treating conditions like heart failure and ischemia-reperfusion injury, where mitochondrial dysfunction plays a significant role.

4. Anti-Aging Properties

Because mitochondrial damage is closely associated with aging, SS-31 may have anti-aging benefits. By improving mitochondrial function and reducing oxidative stress, SS-31 could help slow the aging process at the cellular level, promoting healthier aging and potentially extending lifespan.

5. Treatment of Metabolic Disorders

There is growing interest in SS-31’s potential to treat metabolic disorders such as diabetes. Mitochondrial dysfunction is linked to insulin resistance, and improving mitochondrial function with SS-31 could enhance glucose metabolism and insulin sensitivity.

6. Increased energy levels 

SS-31 peptide boosts energy by targeting and protecting mitochondria, the "powerhouses" of your cells. Mitochondria generate ATP, the main energy source for cellular functions. 

As we age or experience stress, mitochondrial efficiency declines, leading to fatigue and reduced cellular energy. SS-31 works by stabilizing the mitochondria, preventing oxidative damage, and improving ATP production. This results in increased cellular efficiency, allowing you to feel more energized. It's like upgrading an old car engine—it runs smoother, more efficiently, and with less strain, giving you more stamina throughout the day.

What to listen to next:

To learn more about how other peptides can help with neurodegenerative diseases, listen to our podcast discussing the potential use of GLP-1 agonists in Alzheimer’s disease and how they work or DIHEXA and cognitive health.

To learn more about how other peptides can help heart health, listen to our podcast about GLP-1 agonists in the context of post-MI management.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

If you're like most people, you've probably felt stressed at some point, whether it's day-to-day stress, that part of your home or work life, or due to a scary experience.

Today we're going to talk about a question I get often. How do I manage my stress so that I can help my mind and body? We'll also discuss Selank, a peptide therapy option available to help with stress. 

The fact is, stress is a normal part of being alive. When stressed, our bodies release cortisol (the stress hormone). Short-term, this hormone helps to keep you safe by increasing your heart rate, blood pressure, and blood sugar. 

But, with repeated stress, you begin to feel tired and depressed and experience weight gain. You may also experience upset stomach, constipation, diarrhea, headaches, difficulty sleeping, and low sex drive.

We've talked about chronic stress before in the context of weight gain. And if you remember correctly, stress can come from all types of life events (e.g., losing a job, experiencing a death, going through a divorce or separation, and childbirth). What is stressful for one person may not be stressful for someone else. Depending on our current situation, certain things can make us more sensitive to life's stresses (e.g., financial situation, health situation, a support system at home). 

But one thing is certain: reducing stress can help reduce stress's effects on our minds and bodies. Engaging in regular physical activity, if able, practicing meditation, spending time with friends or family, getting quality sleep, talking to a therapist, and eating healthy food can help relieve the effect of stress.

What about Selank?

So you've tried everything to reduce your stress levels. You've practiced mindfulness and meditation, and you're getting regular exercise. You've focused on eating a healthy diet and getting 7 to 8 hours of sleep a night. You've even talked to a therapist about your concerns.

No matter what you've tried, you continue feeling stressed (low energy, anxious, or irritable). 

This is where Selank may help. 

You may hear Selank referred to as the "anti-anxiety" peptide or a "nootropic." Selank stabilizes blood enkephalins. Enkephalins are natural peptides found in the brain that help with stress. Not only can it reduce stress, but it can also relieve anxiety and improve memory. 

In clinical trials, it has been shown to provide an anti-anxiety effect. It does this by enhancing the effect of GABA. GABA is an inhibitory neurotransmitter. It slows down your brain by blocking signals in your central nervous system, which produces a calming effect. 

While most traditional anxiety prescription medications can cause bothersome side effects, clinical studies have shown that Selank doesn't. You should not experience side effects like drowsiness, dependence, or withdrawal symptoms. 

In addition to its anti-anxiety benefits, its nootropic actions improve cognitive function, attention, memory, and motivation. Selank increases the amount of brain-derived neurotrophic factor (BDNF), an important brain growth compound in the hippocampus that helps with learning and memory.

Other studies have shown Selank to increase levels of IL-6, an inflammatory protein in the body that helps fight off infections. It's also shown to decrease blood sugar and prevention of weight gain. This could be very helpful for those with metabolic syndrome. 

How do I take Selank?

Selank is given as an intranasal (into the nose) spray daily or as needed. You should not use more than you're prescribed dose. Studies suggest doses above the maximum amount can reduce your response to Selank.

Possible side effects include headaches. Also, since it's a nasal spray, you may experience a stinging or burning sensation in your nose or an unpleasant taste in your mouth. As always, you should tell your healthcare provider about any side effects you experience. 

You can find out more information about Selank and stress management at pepties.com. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Today, we’re talking about how nootropics and peptides like Semax (See-max) and Selank (SEH-lank) work together to support cognitive health, improve focus, and reduce mental fatigue.

Let’s start with nootropics. These are substances that are designed to support and enhance mental performance. Some work by improving memory, others help with focus, alertness, or reducing brain fog.

Nootropics can be:

• Natural, like L-theanine or Lion’s Mane
  
  

• Nutraceuticals, like Alpha-GPC or CDP-Choline, which support neurotransmitter production
  
  

• Or synthetic, like Modafinil or racetams “RASS-uh-tams”, which are often used off-label to promote wakefulness and focus
  
  

Most nootropics work by affecting levels of key brain chemicals like dopamine, acetylcholine, or norepinephrine. They don’t “make you smarter,” but they can improve how efficiently your brain is working—especially under stress or fatigue.

Now, let’s talk about peptides—specifically Selank and Semax, which are two of the most well-known nootropic peptides.

Selank is more about calming and emotional regulation, while Semax leans into cognitive enhancement and brain performance. Think of Selank as the anti-anxiety sidekick and Semax as the mental sharpener.

Selank works by boosting GABA activity, which helps calm the nervous system. That’s why it’s often used to reduce stress and anxiety without causing drowsiness or dependence — unlike traditional anti-anxiety meds. Interestingly, it also slightly increases BDNF, the brain growth factor that supports memory and learning. Semax, on the other hand, has a much stronger impact on BDNF. It’s derived from ACTH, but it doesn’t raise cortisol levels. Instead, it enhances BDNF, dopamine, and serotonin activity, making it great for improving focus, mental energy, and even mood.

And that’s what makes them such a powerful combo for some people. Selank helps create a calm, clear mental space — kind of like reducing background noise — while Semax boosts the brain’s signal, improving neuroplasticity, motivation, and mental clarity. Together, they offer a full-spectrum brain support: emotional balance and cognitive performance. Whether you're dealing with brain fog, anxiety, or just want to perform at a higher level, these peptides could be worth exploring.

Stacking Nootropics with Peptides

One of the most popular strategies for cognitive support is to combine or stack peptides with nootropics.

For example:

• Selank pairs well with L-theanine for calming, focused energy. L-theanine, an amino acid found primarily in green tea, promotes relaxation and reduces stress without causing drowsiness by increasing calming neurotransmitters like GABA and serotonin. Lion’s Mane mushroom, a natural nootropic found in both wild and cultivated forms, can be stacked with Semax to naturally support memory, focus, and neurogenesis.

• Semax can be used with Alpha-GPC to support both short-term concentration and long-term brain health. Alpha-GPC (Alpha-glycerophosphocholine) is a choline-containing nutraceutical, often derived from soy or sunflower lecithin, that acts as a powerful nootropic. It increases levels of acetylcholine, a key neurotransmitter involved in learning, memory, focus, and muscle control. Because of its ability to cross the blood-brain barrier efficiently, Alpha-GPC is often used to enhance cognitive function, support brain health and neuroprotection, and improve physical performance by boosting power output and recovery in athletes.

• Semax can also be used with CDP-Choline for memory support, brain fog, and age-related cognitive decline. It too is a nutraceutical that provides choline, which the brain uses to produce acetylcholine, a neurotransmitter essential for memory, learning, and focus. It also delivers cytidine, which converts into uridine—a compound that supports neuron repair and brain cell membrane synthesis. 

Alright, so one question we get a lot is, “What’s the difference between CDP-Choline and Alpha-GPC?”

It’s a good one—because they’re both great choline sources, but they work a little differently. Alpha-GPC delivers choline more directly, which means you’ll feel that boost in focus and mental energy a bit faster. It’s especially handy if you’re doing high-intensity brain work or even something athletic.

Lastly, I also want to dive into something a lot of people are curious about, Modafinil and racetams (RASS-uh-tams). 

Modafinil (Provigil) is a prescription, stimulant medication used to treat sleep disorders (e.g., narcolepsy and obstructive sleep apnea) and shift work disorder. It’s also used off-label as a focus-enhancing nootropic. It works by promoting wakefulness in the CNS. Researchers don’t know exactly how it works, but it appears to affect areas in the brain that control attention and wakefulness.

Racetams (e.g., Piracetam, Aniracetam, or Oxiracetam) are a class of compounds that enhance acetylcholine activity and neuroplasticity, leading to better learning, memory, and focus with subtle, non-stimulant effects. 

While Modafinil provides a noticeable surge in alertness and productivity, racetams offer a more gradual cognitive boost that can be ideal for sustained mental performance.

Just remember, peptides provide foundational support—helping your brain repair and function better long-term. Nootropics can then layer on immediate effects, like sharper focus or improved mood.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, please follow or leave a review. And if there’s a topic you’d like to hear more about, feel free to reach out—we’d love to hear from you. As always, have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Last week we focused on medications that may decrease interest in sex. We also covered PT-141 (bremelanotide), a peptide therapy used to help women and men with low sex drive, and Kisspeptin-10, which helps with increased arousal and sexual attraction. 

Since then, we have had a lot of questions from our women podcast listeners about other common causes and symptoms of low sex drive and how it's diagnosed and treated. So today, we thought we could help answer some of those questions.

It's important to know that there's a difference between sex drive and arousal. A person's sex drive is the desire or interest in having sex. Sexual arousal is feeling "turned on" or sexually excited. A person can feel sexually aroused but not want sex. Likewise, a person can want sex and not be able to become physically aroused. 

What are some symptoms related to low sex drive?

People can experience little to no interest in all types of sexual activity (including masturbation and sexual fantasies). Others can have little to no sexual thoughts or difficulty initiating sex or find little to no pleasure in having sex.

What are some common causes of low sex drive in women besides medications?

We touched on this a bit last week, but low sex drive in women has many potential causes. Medical conditions like depression, hypothyroidism, diabetes, and high blood pressure, may all cause a low sex drive. Even hormonal changes (e.g., during pregnancy, after childbirth, or while breastfeeding) can decrease interest in sex. In fact, this can happen for months after having a baby. During this postpartum period, your body undergoes significant hormonal and physical changes that may lead to a lower sex drive. The good news is that once you've completely recovered from your pregnancy and delivery, your sex drive should recover.

And some people with relationship or mental health issues have a low sex drive. This shouldn't be a surprise that your emotional health can affect your sex drive. Clinical studies have shown that low sexual desire is strongly linked to depression and anxiety.

Also, many women suffer pelvic floor disorders (e.g., recently having a baby, being in menopause, being overweight, or heavy lifting regularly) that can cause pelvic pain during sex. And pain with sex can cause a bunch of negative emotions related to sex itself, like frustration, fear, and stress. 

Speaking of stress, chronic, everyday stress can also cause a low sex drive. We've talked about chronic stress before in the context of weight gain. I think it's important to remember that cortisol is a hormone released into your bloodstream when your body undergoes stress. This hormone causes an increase in your heart rate and blood pressure. However, over time, if your body experiences repeated stress, you may begin to feel tired and depressed. As a result, your body will start using other hormones like estrogen and testosterone to overcome high-stress levels. This leads to a low sex drive.

How is low sex drive diagnosed?

It's common to experience a low sex drive as we age and in menopause. This is due to decreasing testosterone levels and other physical changes (e.g., vaginal dryness, burning, and irritation) that occur as we age. A decline in sexual desire over time is normal for many people. Still, when a low sex drive continues longer than 6 months and affects a person's quality of life (e.g., causes emotional distress or relationship issues), this can be considered hypoactive sexual desire disorder (HSDD).

There's no test to diagnose HSDD; however, having an open, honest discussion with your healthcare provider about your sex drive is a good start. They can determine if your low sex drive is due to psychological issues, medication, or if there's another cause, like an infection or hormonal changes. 

If your medication is causing a low sex drive, your healthcare provider may have you stop the medication if it's not needed. Or they may switch you to an alternate medication that doesn't cause a low sex drive. But don't stop your medication without speaking to your healthcare provider first.

Your healthcare provider may suggest other medications or peptides like PT-141 or Kisspeptin-10. 

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. 

This may include syringes, needles, alcohol pads, and a sharps container.

Several weeks ago, we discussed the importance of sleep and the different peptide therapy options available to help with sleep like DSIP, selank, CJC 1295, tesamorelin, and ipamorelin. 

Since then, we have had questions about natural ways to stay awake and alert for people dealing with fatigue.

Remember, it's normal to have an occasional sleepless night. Maybe you had a stressful day at work, an illness, or you’re moving. The next day, you wake up tired, irritated, and unable to concentrate at work or home. 

The good news is, for most people, this feeling is temporary. But for some people, the physical health problems associated with chronic sleeping problems, increase their risk of depression, diabetes, high blood pressure, heart disease, stroke, and unintentional weight gain. 

They can also have decreased immune function and get sick more often.

Sleepless nights can be incredibly frustrating and significantly affect your mood, making it difficult to get through your day. 

What are the best natural ways to help with fatigue?

Tiredness can be a symptom of dehydration. So if you're not drinking enough water, you may have low energy and experience sluggishness. Make sure to stay hydrated, so you feel well-rested throughout the day. But remember, you may want to avoid drinking water up to 2 hours before bed. This way, you're not causing an unwanted trip to the bathroom in the middle of the night.

Healthy diets full of nutrient-dense foods like sweet potatoes and bananas will give the body a steady energy supply. In addition, your meals should include a variety of fruits and vegetables, whole grains, and healthy sources of proteins (e.g., legumes, nuts, fresh fish, low-fat dairy, or lean cuts of meats). This will help increase your energy levels and combat fatigue.

Most of us know that exercise is good for us. But let's face it, sometimes we all need the motivation to get up and move our bodies. And you may be surprised to learn that exercise can do more than strengthen your muscles or help you lose weight. 

In fact, regular exercise can boost energy, promote restful sleep, and help lower your risk of type 2 diabetes, heart disease, and cancer. It can even help reduce chronic pain and stress, which may help improve your mood. 

This is because exercise improves circulation and helps your body function more efficiently. 

Because stress and fatigue are linked, practicing things like meditation and yoga may relieve stress, improve your sleep quality, and reduce your fatigue.

Lastly, soaking up the sun is a great way to get more vitamin D. Vitamin D has been shown to increase energy levels, boost mood, and improve sleep quality. Just 10-15 minutes of daily sun exposure for most people can provide many advantages to your mental and physical health. People with darker skin may need more time since darker skin absorbs the sun differently (around 25-40 minutes). Try exercising outside or eating lunch outside to get extra sunshine in your daily routine.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

This week we are continuing our mini-series on low testosterone and testosterone replacement therapy (or TRT). Today we'll cover what low testosterone (or low T) is. We'll also go over the symptoms of low T, how to test for low T, and the difference between free testosterone (free T) and total testosterone (total T). All this and more in less than 5 minutes.

What is low T?

The American Urological Association (AUA) recommends that testosterone therapy is prescribed only to men who meet the clinical and laboratory definition of testosterone deficiency which is a testosterone level of less than 300 ng/dL. If you feel fine, the low testosterone level itself is not a cause for concern. But the likelihood is that you'll experience symptoms of low T, which means it's time to call your healthcare provider. 

What are the symptoms of low T?

When your testosterone drops below 300 ng/dL, you may experience the following symptoms:

• Irritability or sadness
• Having trouble focusing or concentrating
• Hot flashes
• Feeling tired
• Losing muscle mass
• Hair loss
• Low energy during exercise or decreased stamina
• Weight gain
• Low sex drive
• Erectile dysfunction AND
• Fertility issues

How can I test for low T?

You should go to a healthcare provider or clinic specializing in hormone evaluation. The provider will take a blood sample and may look at a few different markers in your blood to help determine the next steps for maintaining normal testosterone levels.

It's important to know that not all tests are created equal. Make sure your provider uses a blood test to check your testosterone levels, not a saliva test. Saliva test results aren't as reliable as blood tests tracking hormonal changes. Furthermore, your reference results aren't reproducible. Each saliva test you take will achieve a different result. Also, saliva testing can only measure your free testosterone levels but not your total testosterone levels.

You should fast for 10-12 hours before taking your test, and you must complete your test no later than 10 a.m. According to the AUA, testosterone levels peak in the early morning between 7 a.m. and 10 a.m. and steadily decline throughout the day.

What is the difference between free T and total T?

Most of the testosterone in the body is attached or bound to proteins like sex hormone binding globulin (SHBG) and albumin and moves around your body, bound from place to place. 

Total T measures the amount of attached and free testosterone in your body. Free T isn't bound to anything. Free T is the type of testosterone your body uses. Free T helps you build and maintain muscle mass and decrease body fat. It also helps with mood. 

It turns out that the symptoms you feel from low T aren't just caused by the total amount of testosterone in your blood. The number of free T matters too. You could have normal total T levels but still suffer from symptoms of low T because you have low free T levels. This could be due to high levels of SHBG in your blood.

If your total or free T levels are low, testosterone replacement therapy (TRT) may help. More on this next week.

Thanks for listening! You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together along with information about low testosterone and testosterone replacement therapy.

We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tip

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

BPC-157 (body protection complex) is a peptide consisting of 15 amino acids. It’s become popular in recent years for its potential therapeutic benefits, particularly in tissue repair and inflammation reduction. 

BPC-157 is derived from a protein found in the human stomach. It promotes healing in a variety of health conditions, from muscle and tendon injuries to gut health and brain fog. 

BPC-157 is available as an oral pill or an injection into the fatty tissue (subcutaneous injection).

In this podcast, we’ll discuss the differences between these two dosage forms and which may be better for you.

Injectable BPC-157

Absorption and Bioavailability 

Injectable BPC-157 can be injected subcutaneously (under the skin) or intramuscularly (into the muscle). Injections ensure that the peptide bypasses the digestive system, allowing for direct entry into the bloodstream. As a result, the peptide's bioavailability is significantly higher with injections. Bioavailability refers to the proportion of a medication/peptide that enters the circulation and is able to have an active effect.

Effectiveness

Injectable BPC-157 is often seen as a better choice for healing injuries like torn ligaments and tendons, muscle tears, and joint damage. Injections can be given close to the injury site, which might help it heal faster.

Dosage and Administration

The dosage for injectable BPC-157 typically ranges from 400 to 600 micrograms per day for up to 12 weeks, followed by a one-month break. The BPC-157 dose and length of treatment depend on the severity of the condition and the individual’s response. 

Remember: Using injectable medication requires careful handling. You need to keep everything clean to avoid infections and use the right technique to ensure the peptide's effectiveness. 

Pros and Cons

• Pros:

• High bioavailability and potency

• Direct application to target areas

• Faster onset of therapeutic effects

• Cons:

• Requires needles and sterile conditions

• Potential discomfort or pain at injection sites

• More complex administration compared to oral forms

Oral BPC-157

Absorption and Bioavailability

Oral BPC-157 is taken in capsule or tablet form and digested in the gastrointestinal tract before entering the bloodstream. This route of administration can result in lower bioavailability due to the peptide being broken down by digestive enzymes and stomach acid. However, many people who use oral BPC-157 argue that it still retains sufficient bioactivity to be effective, particularly for gastrointestinal conditions.

Effectiveness

Oral BPC-157 is often chosen for its convenience and potential benefits for digestive health. Since it directly interacts with the gastrointestinal lining, it may be more effective for treating issues such as inflammatory bowel disease (IBD), ulcers, and leaky gut syndrome. It also helps to restore the gut microbiome. While systemic effects (e.g., muscle or tendon healing) might be less pronounced compared to injections, oral administration still provides therapeutic benefits, albeit possibly at a slower rate.

Dosage and Administration

The dosage for oral BPC-157 generally ranges from 500 to 1000 micrograms per day, reflecting its lower bioavailability. The exact dosage can vary based on individual needs and the condition being treated. Oral BPC-157 is easy to administer, making it more user-friendly for those uncomfortable with injections.

Pros and Cons

• Pros:

• Easy and painless administration

• Suitable for gastrointestinal issues

• No need for sterile conditions or needles

• Cons:

• Lower bioavailability compared to injections

• Possibly slower therapeutic effects for non-gastrointestinal conditions

• Less targeted delivery

Choosing Between Injectable and Oral BPC-157

The choice between injectable and oral BPC-157 depends largely on the specific condition being treated, the desired speed of recovery, and personal preferences regarding administration.

• For Acute and Targeted Injuries: Injectable BPC-157 is generally preferred for its higher potency and faster results. Athletes and individuals with significant muscle, tendon, or ligament injuries might benefit more from injections.

• For Gastrointestinal Health: Oral BPC-157 may be more effective due to its direct interaction with the digestive tract. It is also more convenient for daily use and suitable for individuals who are averse to injections.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

With all the buzz surrounding semaglutide shortages, we wanted to talk about why the shortages are happening and what to do if you are in the middle of this frustrating drug shortage. 

Why is there a drug shortage?

Simply put, there has been an increased demand for semaglutide. 

On May 4, 2023, Novo Nordisk, the manufacturer of Wegovy (semaglutide), announced that they would only be able to supply limited quantities of Wegovy 0.25mg, 0.5mg, and 1mg dose strengths to both wholesalers and retail pharmacies. Because of this, the manufacturer won't be able to meet the anticipated patient demand. The company predicts that many patients will have difficulties filling their Wegovy prescriptions at these doses through September. 

Now, the company does state that they have got additional help from a second contract manufacturing company to help increase production and will pause marketing efforts in the meantime with the hopes of helping with supply.

Wegovy alternatives for weight loss

Before we review the semaglutide alternatives for weight loss, I want to review the difference between Ozempic and Wegovy. 

Both Wegovy and Ozempic have the same active ingredient: semaglutide. 

Wegovy is an FDA-approved, once-weekly injectable weight management medication that's been studied in people who do and do not have type 2 diabetes. And while it's not approved to treat these conditions, adults taking Wegovy noticed improvements in blood pressure, cholesterol, and blood sugar.

Ozempic is approved to treat type 2 diabetes. In fact, during clinical trials, people taking Ozempic lowered their average blood glucose (A1C) by over 1%. And, if you have heart disease, it may reduce your risk of having a heart attack or stroke. Ozempic isn't approved for weight loss, but since its active ingredient is semaglutide, it can cause weight loss as a side effect. This is why Ozempic is sometimes prescribed off-label for people with and without diabetes to help them lose weight.

If you're unable to get name-brand Wegvoy for weight loss due to drug shortage or, in some cases, prescription coverage challenges, you may want to consider a couple of alternatives.

Compounded semaglutide

Under certain conditions, the FDA allows pharmacies to make medications with a drug shortage. The semaglutide is produced by specialized pharmacies that source pharmaceutical-grade active ingredients (amino acids in this case) and combine them to make a finished medication or product. 

If you're going to purchase semaglutide for weight loss through a compounding pharmacy or a healthcare clinic, you'll want to make sure that you ask if the semaglutide base was made at a facility that's registered with the FDA and follows good manufacturing practice at their facility. This will ensure that the semaglutide you receive doesn't contain extra ingredients and is safe for use.

Your semaglutide shouldn't be labeled "for research use only," as unregulated chemicals aren't meant to be used in people.

What about Saxenda?

An alternative to semaglutide is Saxenda (liraglutide). This is another glucagon-like peptide-1 (GLP-1) agonist that acts like semaglutide. It works by slowing down how quickly food leaves your stomach. This makes you feel full longer and suppress your appetite. 

Compared to semaglutide for weight loss, adults taking Saxenda lost an average of 6% of their starting body weight compared to 16% with semaglutide (Wegovy). Also, unlike semaglutide, which is injected under the skin once weekly, Saxenda must be injected daily. 

What about Trulicity?

Like Ozempic, Trulicity (dulaglutide) is a once-weekly injectable GLP-1 agonist that isn't approved for weight loss. It's approved to treat type 2 diabetes in adults, although weight loss is possible. 

What about Rybelsus?

We've talked about Rybelsus before. It's the oral version of semaglutide. A pill you take by mouth every day. However, it's not approved for weight loss management even though loss of appetite may occur. Rybelsus should only be used to treat type 2 diabetes. 

Rybelsus is great for people with type 2 diabetes that don't want to give themselves injections, but unlike Ozempic, Rybelsus doesn't have the same heart-related benefits (lower risk of heart attack and stroke). The tablets must also be taken first thing in the morning with no more than 4 ounces of water. You must wait 30 minutes before eating, drinking, or taking other medications to fully absorb the Rybelsus. 

It's also important to remember that Rybelsus comes in 3mg, 7mg, and 14mg strengths. Only patients taking the Ozempic 0.5mg dose for type 2 diabetes can switch to Rybelsus.

What about Mounjaro? 

Mounjaro (tirzepatide) is a newer, once-weekly injection approved for type 2 diabetes. It works on the same targets as semaglutide, plus an additional target. This results in a greater A1C and weight loss reduction compared to Ozempic. But, Monjaro has yet to be approved for weight loss or the same heart benefits.

A 72-week study with almost 940 adult participants reported an average weight loss of nearly 15.7% (approximately 35 pounds). The placebo group lost an average of 3.3% of their body weight. 

If you're having difficulties getting your semaglutide for weight loss, your healthcare provider or pharmacist may be able to help. This may include things like compounded semaglutide or switching to a medication like Saxenda.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. You can find out more information about semaglutide on our previous podcasts.

If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier.

Have you ever wondered how your brain stays sharp and focused? There's a fascinating peptide called DIHEXA that plays a superhero role in boosting brain power. Imagine a tiny helper that supports your memory, thinking skills, and overall brain function. In this podcast, we'll cover DIHEXA, understanding what it is, how it works, and the incredible benefits it may offer in optimizing brain function. 

What is DIHEXA?

Think of it as a tiny building block for your brain. This peptide is like a superhero sidekick, helping your brain cells communicate better and ensuring everything runs smoothly. 

How Does DIHEXA Work?

DIHEXA comes from angiotensin IV. Angiotensin IV is a peptide in your body that helps regulate blood pressure and fluid balance. It has many effects on the central nervous system, like helping the process of learning and taking in new information, experiences, and skills (memory acquisition). It also affects our memory recall and object recognition.

DIHEXA's secret lies in its ability to enhance a molecule called acetylcholine. Think of acetylcholine as a messenger that helps brain cells talk to each other. DIHEXA ensures plenty of this messenger is around, making communication between brain cells clearer, faster, and more efficient. This means your brain can process information quicker and remember things more effectively. It's like giving your brain a turbo boost!

What are the benefits of DIHEXA?

First off, it's like a personal trainer for your memory. It helps strengthen your ability to remember things, like your favorite song lyrics or important dates, which can be helpful in people with Alzheimer's. Next, DIHEXA enhances your focus and attention. Imagine concentrating better during class or when you're working on a project – that's what DIHEXA can help you achieve! 

DIHEXA also supports your problem-solving skills. It's like having a clever friend who helps you solve puzzles faster. Plus, it's been shown to promote overall brain health (mental stamina), keeping your thinking skills sharp as you grow older. 

What is the typical dose of DIHEXA?

DIHEXA can be taken by mouth or used as a topical cream. The typical dose is 20 to 80 mg, 4 to 5 days per week, depending on why you're using it. It's also important to know that you shouldn’t use DIHEXA when taking cerebrolysin. 

We discussed cerebrolysin several weeks before, but I'd like to review what cerebrolysin is and how it helps with cognitive health. Cerebrolysin is a nootropic peptide that supports neurons' growth, survival, and maintenance, aiding in their communication and overall brain health. It may help people with traumatic brain injury (TBI) or stroke recovery and mood enhancement.

It can also improve memory, learning, and overall cognitive performance. And the drug's antioxidant and anti-apoptotic properties help protect brain cells from damage and death, potentially slowing down the progression of neurodegenerative disorders like Alzheimer's and Parkinson's.

If you or a loved one are considering DIHEXA as a treatment option, consult a qualified healthcare professional to determine its suitability and safety for your specific needs. As science advances, the quest for unlocking the full potential of the human brain remains a fascinating journey, with DIHEXA paving the way for new possibilities in the field of neuropharmaceuticals.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. 

Several weeks ago, we briefly talked about oral semaglutide (Rybelsus) when we addressed the current concern surrounding the Wegovy shortage. And although it's currently not approved for weight loss, there is a lot buzz surrounding the hope that it soon will be, and its clinical results for weight loss have been promising. But remember, you can't always believe what you read unless there's science to back it up. 

Today I'd like to talk about oral semaglutide, the current clinical studies surrounding its efficacy for weight loss, and things to consider with oral weight loss medications. 

What is Rybelsus?

We've talked about Rybelsus before. It's the oral version of semaglutide. It contains the same active ingredient as Ozempic and Wegovy. Because all three of these medications have the same active ingredient, they work the same way in your body. After you eat a meal, semaglutide helps to lower your blood sugar by mimicking a gut hormone called glucagon-like peptide-1 (GLP-1). This causes your pancreas to release insulin and blocks your liver from releasing sugar. It also slows down how quickly food leaves your stomach. This makes you feel full longer and suppress your appetite. All of these things together lead to weight loss. 

The most obvious difference between the medications is how they're taken. Wegovy and Ozempic are once weekly injections, while Rybelsus is a pill you have to take by mouth every day.  

Like Ozempic, Rybelsus is not approved for weight loss management even though loss of appetite may occur. Currently, Rybelsus should only be used to treat type 2 diabetes. 

It's also important to remember that Rybelsus comes in 3mg, 7mg, and 14mg strengths. Only patients taking the Ozempic 0.5mg dose for type 2 diabetes can switch to Rybelsus.

And, like Wegovy and Ozempic, Rybelsis can also cause similar stomach-related side effects like nausea, vomiting, diarrhea, and constipation. 

What do the clinical studies show?

A 68-week study with almost 670 adult participants reported an average weight loss of nearly 15% taking oral semaglutide 50mg daily. The placebo group lost an average of 2.4% of their body weight. This is similar to the results from the largest Wegovy trial (2,000 adult participants), which showed about 15% average weight loss within the same time period.

Things to consider

Higher doses: The Rybelsus doses studied for weight loss were 50 mg daily. Currently, Rybelsus comes in 3mg, 7mg, and 14mg strengths. The manufacturer plans to request FDA approval for the 50mg dose if approved for weight loss. 

Convenience: The tablets must also be taken first thing in the morning with no more than 4 ounces of water. You must wait 30 minutes before eating, drinking, or taking other medications to absorb the Rybelsus fully. Initially, injections may seem scary, but with some practice, giving yourself a shot under the skin can be painless. Often the needles used for subcutaneous injections are as thin as two strands of hair. Would you rather give yourself a weekly injection or remember to take a daily pill?

Heart benefits: Rybelsus is great for people with type 2 diabetes who don't want to give themselves injections. However, unlike Ozempic and Wegovy, Rybelsus doesn't have the same heart-related benefits (lower risk of heart attack and stroke). In fact, studies have shown to lower the risk of death due to heart problems in certain people by 26%.

Medication Interactions: Rybelsus has been shown to lower the absorption of levothyroxine (a thyroid medication) by 33%. Make sure to let your healthcare provider know your full list of medications so they can check for potential drug interactions while taking Rybelsus.

Cost: The average cash price (without prescription insurance) of Rybelsus is $1,100 for 30 tablets (3mg, 7mg, or 14mg tablets). This is lower than the average cash price of Wegovy which is about $1,500 for 4 prefilled pens. Price tags on these weight loss medications don't come cheap and, without the help of insurance, are out of reach for many. I don't anticipate the price for 50 mg Rybelsus tablets to be much better. It will likely have a similar cash price of around $1,000-1,1500 for 30 tablets.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. You can find out more information about semaglutide on our previous podcasts.

If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier.

This week we are continuing our mini-series on semaglutide. Today we'll cover how semaglutide is dosed, the side effects of semaglutide, and potential interactions with other medications. 

How is semaglutide (Wegovy) dosed and given?

Semaglutide for weight loss is given as a weekly injection under the skin (subcutaneously). You can give the injection with or without food into your abdomen, upper arm, or thigh. You should avoid injecting into the same spot every time. But you can inject into the same body area (e.g., abdomen) as long as you rotate your injection site. 

The target maintenance dose of semaglutide is 2.4 mg once weekly. Before reaching this target dose, your healthcare provider will start you on the starting dose of 0.25 mg once a week. After that, you will slowly raise your dose every 4 weeks until you reach the full dose of 2.4 mg once weekly. 

Some people may not be able to reach the target dose due to side effects. If this happens to you, your healthcare provider may decide to keep you at your current dose for an additional month before raising your dose. 

What are the potential side effects of semaglutide (Wegovy)?

The most common side effects include the following: ***Stomach related

• nausea
• diarrhea
• vomiting
• constipation
• headache
• tiredness
• bloating
• burping

In some cases, semaglutide can cause more serious side effects. This medication has a boxed warning — the FDA's most serious warning — regarding a potential thyroid tumor risk. Although this risk has only been confirmed in animal studies (human studies have yet to confirm this risk), you shouldn't take this medication if you have a personal or family history of thyroid tumors. 

Other serious side effects can include:

• pancreatitis (inflamed pancreas)
• gallbladder disease
• kidney problems (more common in people who are dehydrated or already have kidney problems)
• allergic reactions (problems breathing or swelling of the face, lips, tongue)
• fast heart rate
• eye problems in people with Type 2 diabetes
• changes in mood or behavior (e.g., suicidal thoughts have been reported with other weight loss medications)

*It’s important to know that the most common side effects are stomach-related and usually subside over time. You can always talk to your healthcare provider or pharmacist if you have questions or concerns about bothersome side effects.

Can semaglutide interact with other medications?

Since semaglutide can lower your blood sugar, it can react with other medications that help lower your blood sugar, like insulin and metformin. So if you are taking medications to help lower your blood sugar, your healthcare provider may lower your dose while starting you on semaglutide. And if you have Type 2 diabetes, you'll also want to monitor your blood sugar closely before and during treatment to make sure your sugar readings are within a safe range.

Another potential interaction is with all oral medications. Because semaglutide slows down how quickly food leaves your stomach, this may also affect how certain oral medications are absorbed by your body when taken with semaglutide. You'll want to watch for any changes with your medication after you start semaglutide.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Today we are talking about everything collagen peptides! We’ll cover the benefits of collagen peptides, how to take collagen peptides, and potential side effects. All this and more in less than 2 minutes. 

What do collagen peptides do for you?

Let’s face it. Our body changes as we age. And some of these changes, like fine lines and wrinkles, are annoying. But other changes to our bodies can cause serious problems in our daily life. Our bones and muscles may become weaker, affecting our coordination and balance. 

While we haven’t discovered the fountain of youth just yet, some benefits you may receive from collagen peptide therapy can help aging skin, nails, bones, joints and heart health benefits:

Bones:

• May help with osteoporosis (condition when bones become weak)

Joints:

• Decrease joint pain
• May help with osteoarthritis (a condition in which the cartilage and bone in joints of the hands, hips, and knees wear down over time)

Muscles:

• May boost muscle mass in aging men

Heart:

• May decrease risk for atherosclerosis (when plaque builds up on the walls of your arteries and causes the wall to thicken and harden)

How do I take collagen peptides?

Collagen peptides can be taken with or without food any time during the day. But, it can be hard to know where to start with so many products available. There are powders, capsules, and gummies to liquid shots, and collagen bars to choose from. 

But, finding the right product type can go a long way. You’ll want to use a collagen peptide that’s convenient and works with your lifestyle. Do you like the convenience of swallowing capsules? Would you rather eat your collagen with your meal? 

Collagen powders are versatile and offer a fun way to add collagen to your daily nutrition. The powders are easily added to your favorite hot or cold drink, baked goods, or mixed into your favorite dish (e.g., eggs, oatmeal, yogurt, and baked goods). Make sure to mix a scoop (or two) of your collagen peptide powder while you’re cooking your dish so the powder can dissolve. 

Capsules may seem more convenient, but look at the label and check the dose. How many grams of collagen is in 1 scoop of collagen powder? Compare that to how many capsules you will need to get the same dose. Remember, capsules tend to be on the large side. If you struggle taking pills, this may not be the most fun part of your day.

Liquid shots are pre-measured and ready to drink, so you can skip the mixing or swallowing capsule routine.

The bottom line, the best way to take collagen peptides is what works best for you.

Is it safe to take collagen peptides every day?

Yes. Collagen peptides are generally well tolerated. But, collagen supplements are made from common food allergens such as fish (marine) and eggs (ESM). People with allergies to these foods should avoid these products made with these ingredients. Some people may experience:

• Allergic reactions (e.g., skin rash, itching, hives, or swelling of face, throat, lips, or tongue)

You should tell your healthcare provider about any side effects you experience. 

What is the best collagen peptide supplement?

Before you wander down the supplement aisle at your local pharmacy or troll the internet in the thick of all the information (or misinformation) when looking for a collagen peptide supplement, choose products made with hydrolyzed collagen, so it’s easier for your body to digest and absorb the collagen peptides. Make sure the collagen is from grass-fed, hormone-free animals, so you’re using the healthiest, cleanest products. 

Our favorite collagen peptide powder is Thorne® Collagen Plus. 

What We Like:

• Gluten free
• Dairy free
• Soy free
• Derived from natural flavors and colors
• 13 grams of grass-fed, hormone-free collagen per serving (1 scoop)

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast please share it with your friends and family on social media. Have a happy, healthy Friday!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We’ve decided to do a mini-series on peptides and weight loss. Over the next few weeks, we'll cover topics like what semaglutide is, how semaglutide works for weight loss, the side effects of semaglutide, and how semaglutide compares to other peptides for weight loss. 

But today, we'll cover semaglutide, what it is, how it works for weight loss, and how effective semaglutide is for weight loss. 

What is semaglutide?

Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist. It was originally approved in 2017 to help control blood sugar in people with Type 2 diabetes. 

You may know semaglutide as Ozempic, the injectable form of the medication or Rybelsus, the oral pill. Both of these dosage forms are used in people with Type 2 diabetes. Wegovy, a higher-dose version, is used to help people lose weight.

Why is semaglutide dosed higher for weight loss?

It was found that people taking Ozempic to help control blood sugar also lost weight while taking this medication. Because of this, the manufacturer of the medication studied semaglutide in people without Type 2 diabetes, but at a higher dose. 

Based on their weight loss findings, the FDA-approved semaglutide (under the brand name Wegovy) for weight loss in adults with a body mass index (BMI) great than or equal to 30mg/kg2 alone or a BMI of 27 mg/kg2 with at least one weight-related issue (e.g., high blood pressure, high cholesterol, sleep apnea, CVD).

How does semaglutide work for weight loss?

Semaglutide should be used with lifestyle changes, including a healthy diet and exercise, to help people lose weight.

After you eat a meal, semaglutide helps to lower your blood sugar by mimicking a gut hormone. This causes your pancreas to release insulin and blocks your liver from releasing sugar. It also slows down how quickly food leaves your stomach. This makes you feel full longer and suppress your appetite. All of these things together lead to weight loss. 

It's important to know that semaglutide is not a type of insulin. Although it stimulates your pancreas to release insulin when sugar is present, it needs your body's insulin to do so. 

It's also important to know that semaglutide isn't a stimulant. Semaglutide does not work like phentermine, a weight loss medication with stimulating effects that help curb your appetite. 

How effective is semaglutide for weight loss?

One reason there's a lot of buzz around semaglutide is the amount of weight people lost during clinical trials. A 68-week study with almost 2,000 adult participants reported an average weight loss of nearly 15% (approximately 35 pounds). The placebo group lost an average of 2.5% of their body weight. 

*The average starting weight of the participants was 232 pounds.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

In a world where fad diets come and go and weight loss supplements flood the market, it's easy to feel overwhelmed and skeptical about what truly works for shedding those extra pounds. But a promising peptide on the weight loss scene is causing quite a buzz: semaglutide (Wegovy). 

If you've got questions about this weight loss medication, you're in the right place. In this podcast, we'll answer the top questions about semaglutide for weight loss.  

What is semaglutide?

Semaglutide is an injectable medication used to help manage weight. It may also lower your blood pressure, improve your cholesterol, and lower your blood sugar. And it must be used in addition to lifestyle changes (healthy diet and increased physical activity).

It was originally approved in 2017 (Ozempic) to help with blood sugar control in type 2 diabetes. People taking Ozempic for diabetes also lost weight, so the manufacturer conducted trials to see if people without diabetes had the same benefit. They found this to be the case, and the FDA approved the medication's use to include weight loss in adults (Wegovy) in 2021. 

How does semaglutide (Wegovy) work for weight loss?

Semaglutide mimics a hormone in your gut that controls hunger (GLP-1). When you eat, GLP-1 is released from the gut and tells your brain you are full. GLP-1 also slows down how fast food leaves your stomach, suppressing your appetite. And GLP-1 tells your pancreas to release insulin after you eat. This lowers your blood sugar. You'll then use the sugar from your food instead of storing this excess sugar as fat. All of these things together lead to weight loss.

Is semaglutide (Wegovy) safe?

Yes, semaglutide for weight loss is FDA-approved and has undergone rigorous testing to ensure its safety and effectiveness. But this doesn't mean that everyone can take it. You should consult a healthcare provider to determine if it suits your specific health conditions.

Who shouldn't take semaglutide?

You should not use semaglutide if you have the following:

• A personal or family history (first-degree relatives such as a parent, sibling, or child) of thyroid cancer or adrenal gland or parathyroid tumors.

• If you are pregnant or breastfeeding

• Type 1 diabetes

• Bariatric surgery (within the past 18 months)

• Active gallbladder disease

• Kidney disease or transplant

You also shouldn't take semaglutide if you're taking other GLP-1 agonists like semaglutide, which include medications like Trulicity, Victoza, or Saxenda.

Who is semaglutide (Wegovy) for?

Semaglutide for weight loss is typically prescribed for adults with a body mass index (BMI) of 30 or higher or those with a BMI of 27 or higher with weight-related medical conditions like high blood pressure, high cholesterol, or diabetes.

What are the most common side effects of semaglutide?

The most common side effects of semaglutide are stomach-related, including:

• nausea

• diarrhea

• vomiting

• constipation

• bloating

• Burping

Most of these stomach-related side effects are due to slowing down digestion.

People have also reported headaches and tiredness (usually due to fewer calories-feeling full and eating less).

How much weight can I lose with semaglutide?

Healthy, sustainable weight loss is 0.5 to 2 pounds per week. And some people routinely lose more than this. 

But what do the clinical studies say? A 68-week study with almost 2,000 adult participants reported an average weight loss of nearly 15% of their body weight (approximately 35 pounds). The placebo group lost an average of 2.5% of their body weight. 

How fast does semaglutide work?

The short answer is that many patients will lose weight in the first week of taking semaglutide if they make lifestyle changes. The first 4 doses are small and are primarily used to gently introduce the peptide to the body without risking stomach-related side effects. 

You need to remember that it's possible to "out-eat" any weight loss medication. So, you may see little to no weight loss in the early weeks without making lifestyle changes. 

But what do the clinical studies say? In clinical trials, people lost about 10% of their body weight during the first 20 weeks. They lost an additional 8% of their body weight through week 68.

How and when do I take semaglutide?

You can inject semaglutide into the fatty tissue of your upper arms, stomach, or upper thighs.

Typically, the dose of semaglutide is increased no faster than once every 4 weeks. For example, you would receive 4 weeks of 0.25mg, then 4 weeks of 0.5mg, and so forth, assuming your side effects are not bothersome. 

Most clinics consider three factors when deciding how to increase the dose for their clients. Each month, you should discuss whether you've experienced bothersome side effects, how well semaglutide managed your hunger, and how much weight you lost. How fast your dose increases depends on the needs of each patient. 

Do I have to take semaglutide on the same day every week?

Yes. It's recommended that you take semaglutide on the same day every week. However, if you need to change the day of the week you take semaglutide (e.g., vacation, illness), you may change the day of the week you take semaglutide as long as your last dose was given 2 or more days before.

Will I have to take semaglutide forever?

The answer to this is complicated. The short answer is it depends on the person. 

Nutrition, physical activity, and good-quality sleep are essential for weight loss. And unfortunately, stress can also impact your ability to maintain a healthy weight. Semaglutide is helpful but may only be necessary for a while if you can adopt lifestyle changes and continue to use them after you stop semaglutide. 

Semaglutide is a medication that's meant to be taken long-term. But some people may want to stop taking it or need to because of side effects or other reasons.

It is possible to regain some weight you've lost after you stop taking semaglutide. The STEP 4 trial found that people switching from semaglutide (Wegovy) for weight loss to placebo regained about 7% of their body weight in 48 weeks.

Why do I regain weight after stopping semaglutide?

It's important to know that regaining weight isn't unique to semaglutide. It's possible to regain weight after stopping any weight loss medication.

Because semaglutide suppresses your appetite, stopping treatment can cause your appetite to return. Also, keep in mind that semaglutide should be used with lifestyle changes, including a healthy diet and exercise. Getting enough quality sleep is important, too. You'll likely regain weight if you stop incorporating these healthy habits into your routine when you stop semaglutide treatment.

Do I need to wean off semaglutide?

No, you don't need to wean off semaglutide. Your healthcare provider will provide instructions for stopping treatment based on your individualized needs.

Where should I store my semaglutide?

Semaglutide should be stored in the refrigerator. Never put your syringes in the freezer.

Although there's no one-size-fits-all approach to weight loss, making informed decisions that align with your personal weight loss goals is very important. 

Remember, semaglutide for weight loss may not be clinically appropriate for everyone. But it can be life-changing for people where it is appropriate. When you're not hungry all of the time, it's much easier to focus on nutrition, regular exercise, stress management, and getting good, quality sleep. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We've all experienced those moments when our digestive system decides to take an unexpected pause, leaving us feeling bloated and maybe even a bit frustrated. It's that unsettling sensation of being backed up that has us feeling uncomfortable. But, beyond the physical discomfort, constipation brings with it a myriad of bothersome symptoms that can disrupt our daily lives. 

From the persistent abdominal pain to the bothersome feeling of fullness post-bathroom visits, constipation is both universally relatable and uniquely personal. 

Today, I want to talk about Trulance (plecanatide), a peptide used in adults to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C).  

What is Trulance?

Trulance, known by its generic name plecanatide, is an important peptide for gut health. It is an FDA-approved medication designed to help alleviate symptoms associated with chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). CIC is long-term constipation with an unknown cause. IBS-C causes belly pain and constipation.

How does Trulance work?

Trulance works by targeting the guanylate cyclase-C (GC-C) in the lining of the gastrointestinal tract. GC-C is a protein that plays an important role in regulating fluid secretion and transit time (the time food is in your gut) in the intestines. Trulance activates GC-C, which increases the amount of fluid in your intestines and speeds up the movement of food through your gut. This softens the stool and promotes bowel movements, relieving bloating and stomach pain. 

What are the common side effects of Trulance?

Trulance is generally well-tolerated; however, some people may experience mild side effects. The most commonly reported side effect is diarrhea. Diarrhea often occurs within the first 4 weeks of taking the medication. Those with CIC have also reported sinus infections, upper respiratory tract infections (URI), bloating, gas, and stomach pain. Those with IBS-C have reported nausea, dizziness, URI, and urinary tract infection (UTI).  

It's important to remember that these effects are usually mild and tend to go away on their own as the body gets used to the medication.

What are the serious side effects of Trulance?

While uncommon, some potentially serious side effects associated with Trulance require immediate medical attention if experienced. These include severe diarrhea, dehydration, or bloody stools. 

Prolonged and severe diarrhea may lead to dehydration, presenting as increased thirst, dry mouth, reduced urine output, dizziness, or fainting. 

In clinical studies, this medication causes severe dehydration, leading to death in young animals. To be safe, children and adolescents should not take Trulance.

There have been rare instances of severe complications like bowel obstruction reported in patients with pre-existing conditions, particularly those predisposed to GI obstruction.

If someone has a history of blockages or structural abnormalities in the intestines, it's important to talk with a healthcare provider before starting Trulance. Monitoring for symptoms of GI obstruction, such as sudden or severe abdominal pain, nausea, vomiting, and inability to pass stool is recommended during treatment with Trulance.

How do I take Trulance?

Trulance is a convenient, once-daily oral tablet. It can be taken at any time of the day, with or without food. And it typically starts to work after a week of daily use. The typical dose for CIC and IBS-C is 3mg daily.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It's vegan, paleo, and keto-friendly.

Welcome to The Peptide Podcast! We’re talking about the peptide info you need to know to start your week in less than 2 minutes! Simple, Fast, and Fun. 

Today we are talking about who we are and why you want to listen! 

The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach.

We’ll keep you up-to-date on everything peptides… From disease management and prevention to performance health, anti-aging strategies, and more — all in about 2 minutes each weekday. 

We’ll give you accurate, unbiased information so you can choose the peptides that suit YOU best.

In our casual and easy-to-understand style, we help you save time and energy for what matters most. 

You’ll get me as your host. An experienced clinical pharmacist. I know all too well that the internet is flawed, confusing, and hard to navigate. I’m passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.

I really believe peptides are the future of individualized medicine. They have certainly shown promise in both clinical and practical application, and yet they remain largely misunderstood by many. I’ve also seen firsthand how peptides have helped my husband. They have been a sort of boost that’s helped improve his overall well-being and his body perform at its peak. It’s been fun to watch.

So stick around, subscribe to our podcast, and let’s take this journey together and learn all there is to know about peptides, their potential benefits, how they work, and so much more! 

I promise to keep it simple, fast, and fun!

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media. Let us know…How have you found peptides to help you? What has worked? What’s not? What have you learned about yourself? And subscribe to our podcast. We’ll see you next time on The Peptide Podcast. Have a happy, healthy week!

Imagine a treatment that not only helps manage diabetes but also holds the potential to reverse kidney failure — what was once thought to be impossible. The recent FLOW study has remarkable groundbreaking evidence that GLP-1 receptor agonists can significantly improve kidney function in chronic kidney disease (CKD) patients. And while researchers try to understand the full implications of these findings, one thing is clear: the landscape of kidney disease treatment may never be the same again. 

In this podcast, we’ll dive into the results of the FLOW trial and explore what they may mean for people at risk for kidney failure.

What are GLP-1 Agonists?

GLP-1 (glucagon-like peptide-1) agonists are a class of drugs that mimic the effects of the natural hormone GLP-1. They enhance insulin secretion, inhibit glucagon release, and slow gastric emptying, improving blood sugar control. Beyond their primary use in diabetes management, GLP-1 agonists have been studied for various conditions, including obesity and cardiovascular disease prevention.

The Study Overview

The FLOW trial, which stands for "Fasting and Long-acting GLP-1 Receptor Agonist in Patients with Chronic Kidney Disease," focused on the impact of GLP-1 receptor agonists, specifically semaglutide, on patients with chronic kidney disease (CKD) and type 2 diabetes (those most at risk for kidney failure).

Researchers observed a remarkable trend: patients receiving semaglutide demonstrated stabilization of kidney function and signs of renal recovery. This was groundbreaking, as reversing kidney damage has long been considered a near-impossible feat.

Study Objectives

The primary goal was to determine whether treatment with GLP-1 receptor agonists could improve kidney outcomes in patients with CKD.

Study Design

• Participants: The study enrolled >3500 adults with type 2 diabetes and CKD.

• Intervention: Participants were randomized to receive either semaglutide or a placebo.

• Primary Outcomes: The main outcomes included changes in glomerular filtration rate (GFR) and the incidence of major adverse kidney events (kidney failure- need for transplantation or dialysis).

Key Findings

1. Renal Function Improvement: Patients on semaglutide showed significant improvements in glomerular filtration rates (GFR), a key indicator of kidney function.

2. Reduced Inflammation: The drugs appeared to lower levels of inflammatory markers associated with kidney damage, suggesting a protective effect.

3. Metabolic Benefits: Improvements in blood sugar control and weight loss were also observed, contributing to overall health and potentially alleviating stress on the kidneys.

4. Adverse Events: The treatment was generally well-tolerated, with a favorable safety profile.

Ethical Considerations

As the results began to emerge, the ethical landscape of the study shifted dramatically. The control group, which was not receiving semaglutide, was found to be at a significantly higher risk of kidney deterioration. With compelling evidence that the GLP-1 agonist was safe and potentially life-saving, the ethics committee determined withholding treatment from any participants was no longer justifiable.

Consequently, the study was halted prematurely to allow all participants access to the medication, prioritizing patient welfare over the continuation of research under an inequitable framework. This decision underscores the ethical responsibility of researchers to ensure that all patients receive the best possible care, especially when clear benefits are identified.

Implications for Future Research

While the early termination of the study raises questions about the completeness of the data collected, it also opens new avenues for further research. The findings encourage more extensive clinical trials to explore the mechanisms behind the renal protective effects of GLP-1 agonists. Additionally, there is a growing interest in investigating these drugs' long-term effects on kidney health and their potential role in preventing disease progression.

As further studies unfold, there is hope that GLP-1 agonists will become a standard part of kidney disease management, potentially transforming outcomes for millions affected by this condition.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

As you age, you might notice dark or brown spots (hyperpigmentation) appearing on your face, arms, or the tops of your hands. These age spots can also develop on your legs, back, and other parts of your body. 

Age spots on the face (cheek, chin, nose, forehead, and upper lip) are typically caused by years of exposure to ultraviolet light from the sun (melasma). These age spots are more common in women and those who are pregnant or taking birth control pills. While experts don't know exactly why this is, it's thought that hormones play a role in melasma. 

Keep in mind that age spots can also be caused by skin injury, such as a cut, burn, or acne breakout. They can also be caused by inflammation, certain medications, and medical conditions such as hypothyroidism, Addison's disease, and certain vitamin deficiencies (B12 or folate). 

While you can't go back in time to apply more sunscreen and prevent age spots, there are peptide therapies that you can use to fade them.

As a refresher, peptides are short chains of amino acids. When used topically, they can penetrate the skin and signal cells to perform specific functions, such as collagen production, skin repair, and pigment regulation. 

In this podcast, we'll talk about how peptide therapy works to help get rid of the appearance of age spots and what you can expect:

How Does Peptide Therapy Work for Age Spots?

1. Inhibition of Melanin Production:

   • Certain peptides can inhibit the activity of tyrosinase, an enzyme crucial for the synthesis of melanin (a dark brown pigment). These peptides help lighten dark spots and even out skin tone by reducing melanin production.

2. Promotion of Skin Renewal:

   • Peptides can stimulate skin cell turnover, promoting the shedding of pigmented cells and the generation of new, healthier skin cells. This helps in fading dark spots over time.

3. Anti-Inflammatory Effects:

   • Peptides can reduce inflammation, which often contributes to hyperpigmentation, especially in conditions like post-inflammatory hyperpigmentation (PIH).

4. Antioxidant Properties:

   • Some peptides have antioxidant properties, protecting the skin from oxidative stress and damage caused by UV radiation, which can exacerbate dark spots.

What are Some Common Peptides Used for Treating Dark Spots?

1. Copper Peptides:

   • Known for their wound healing and anti-inflammatory properties, copper peptides can help improve skin texture and reduce pigmentation.

2. Palmitoyl Tetrapeptide-7:

   • This peptide reduces inflammation and promotes the regeneration of new skin cells, helping to diminish dark spots over time.

3. Oligopeptide-68:

   • Specifically designed to reduce hyperpigmentation by inhibiting melanin production and evening out skin tone.

4. Decapeptide-12:

   • Effective in reducing pigmentation and improving overall skin brightness.

What are the Benefits of Peptide Therapy for Dark Spots?

1. Targeted Action:

   • Peptides can be formulated to specifically target pigmentation pathways, offering a more precise approach compared to general skin-lightening agents.

2. Minimal Side Effects:

   • Peptides are generally well-tolerated, with a lower risk of irritation and side effects than more aggressive treatments like chemical peels or laser therapy.

3. Multi-functional Benefits:

   • In addition to lightening dark spots, peptides often provide additional skin benefits such as improved texture, firmness, and hydration.

Application and Usage of Peptides for Age Spots

• Topical Serums and Creams: Peptides are commonly found in serums and creams. These should be applied as directed, typically once or twice daily, after cleansing and before moisturizing.

• Consistency is Key: Peptide therapy results can take several weeks to become noticeable. Consistent use is crucial for achieving the best results.

• Sun Protection: Peptides used to treat dark spots should be paired with effective sun protection. Sunscreen helps prevent further pigmentation and supports the action of peptides. As a general rule, make sure to choose sunscreen that is broad-spectrum (protects against UVA and UVB rays), SPF 30 (or higher), and water-resistant. 

If you are considering peptide therapy for dark spots, it's recommended to consult with a dermatologist to determine the most suitable peptides for your skin type and condition. Often, combining adequate sunscreen, prescription medications, peptide therapy, and certain procedures such as microdermabrasion, lasers, and chemical peels may be needed.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Are you tired of crash diets and endless hours at the gym that yield minimal results? The journey to sustainable weight loss doesn't have to be a daunting one. Instead of searching for quick fixes, learning to embrace lasting lifestyle changes can help you shed those extra pounds and keep them off for good. 

In this podcast, we’ll talk about ten impactful lifestyle changes that can set you on the path to successful weight loss. These changes are not just about losing weight; they are about embracing a healthier, happier you.

Mindful Eating

One of the fundamental keys to weight loss is adopting a mindful eating approach. It's easy to overeat when you're distracted by your phone, TV, or work. Slow down, savor each bite, and pay attention to your body's hunger and fullness cues. This simple shift can help you eat less and enjoy your meals more.

Balanced Diet

Rather than resorting to extreme diets, focus on maintaining a balanced diet that includes a variety of foods. Opt for whole grains like oatmeal and quinoa, lean proteins like greek yogurt, eggs, and grilled chicken, healthy fats from oily fish like salmon and trout, nuts like almonds, and avocados, and plenty of fruits and vegetables. A balanced diet provides your body with essential nutrients and keeps you feeling satisfied, reducing the temptation to binge on unhealthy snacks.

Fun facts: Research shows that omega-3 polyunsaturated fats (PUFAs) found in oily fish may lower a person’s triglycerides (the fat in the blood). Vegetables are an important source of antioxidants. Antioxidants are molecules that protect your cells from damage. They may also prevent eye problems and lower your risk of heart disease and certain types of cancers. And, the plant-based monounsaturated fats that are found in healthy fats like avocados, almond butter, and olive oil are heart-healthy. In turn, they may protect against heart disease by lowering bad cholesterol (LDL) and triglycerides. They’ve also been found to raise good cholesterol (HDL). 

Portion Control

Portion sizes have grown significantly over the years, contributing to weight gain. Learn to control your portions by using smaller plates, paying attention to the serving size on nutrition labels, and measuring your food. This can help you consume fewer calories while still enjoying your favorite dishes.

Hydration

Sometimes, thirst can be mistaken for hunger. Drinking an adequate amount of water throughout the day can help you differentiate between the two. The general rule is to take your weight in pounds and divide the number in half. This is about how many ounces of water you should drink daily. For example, a person who weighs 220 lbs should drink about 110 ounces or a little over 3 liters of water daily. This is about five to six, 20-ounce bottles of water daily.

Fun fact: Not only can water quench our thirst, but it also regulates our body temperature, helps with digestion, removes harmful waste through your urine, sweat, and poop, and carries nutrients in your blood to your organs. It also helps lubricate your joints and prevents constipation. 

Vegetables like cucumber, iceberg lettuce, tomato, and zucchini also contain more than 90% water. Melons like cantaloupe and watermelon have some of the highest water content, at more than 90 percent. 

Regular Exercise

Exercise is a vital component of any weight loss journey. You should incorporate both cardio and strength training exercises into your routine. Find activities you enjoy to make it a sustainable part of your lifestyle. Whether it's dancing, hiking, or swimming, regular physical activity can boost your metabolism and help you burn calories. 

The American Heart Association recommends 150 minutes of moderate aerobic activity (e.g., water aerobics, dancing, or gardening) or 75 minutes of vigorous aerobic activity (e.g., running, swimming laps, or jumping rope). It’s also recommended to incorporate two days of muscle-strengthening activities like resistance or weight training, yoga, or pilates.

Quality Sleep

Surprisingly, sleep plays a significant role in weight management. Poor sleep disrupts hormones that regulate hunger and appetite, leading to overeating. Aim for 7-9 hours of quality sleep each night to support your weight loss efforts, depending on your age.

Stress Management

Chronic stress can lead to emotional eating and weight gain. Incorporate stress-reduction techniques like meditation, yoga, or deep breathing exercises into your daily routine. Managing stress can help you make healthier food choices and prevent overindulging in food.

Meal Planning

Meal planning allows you to make thoughtful choices about what you eat, rather than resorting to last-minute, unhealthy options. Set aside time each week to plan your meals, create a shopping list, and prep ingredients. This not only helps you eat healthier but also saves you time and money.

Social Support

Weight loss is often more successful when you have a support system. Share your goals with friends or your favorite healthcare provider. Having people who encourage and hold you accountable can make a significant difference in your journey.

Track Your Progress

Keeping track of your food intake, exercise, and weight can provide valuable insights into your progress. Consider using a journal or a fitness app to record your daily nutrition and physical activities. Seeing your achievements and identifying areas for improvement can keep you motivated.

Remember that everyone's weight loss journey is unique, and it's essential to find an approach that works for you. With dedication, patience, and a positive mindset, you can achieve your weight loss goals and embark on a journey to a healthier, happier you. And, if you’ve made lifestyle changes but still struggle to lose weight, weight-loss medications like semaglutide might be an option for you.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. 

A while back, we discussed our gut microbiome and its importance for digestion and heart health. We also discussed how it's associated with many other health conditions, like obesity, insulin resistance, diabetes, depression, and inflammatory bowel disease.

If you remember correctly, 70% of your immune system is in your digestive tract, and your gut has most of your body's immune cells. It's also home to trillions of microscopic organisms that help your overall health. 

But we really didn't focus on the process of digestion. We all eat food, digest it, and eventually eliminate it from our bodies. In theory, this process sounds simple, but it's pretty complex. 

We've had a lot of questions about digestive enzymes and natural supplements containing digestive enzymes since we had our podcast about BPC 157 and gut health. So today, we'll touch on how digestive enzymes work in the body and go over different digestive enzyme supplements.  

So how does this all work?

We eat food to get the nutrients that our bodies need to keep us alive. For this to happen, we have digestive enzymes. Digestive enzymes are released by the mouth, stomach, pancreas, and small intestine in response to us thinking about, seeing, smelling, and chewing food. 

When you start to chew food, digestive enzymes in your saliva break down your food. Then, after you swallow your food, digestive enzymes in the stomach and intestines further break down the food into smaller components (nutrients) that can be absorbed into the blood. 

Three main digestive enzymes break down our food's fats, carbohydrates, and proteins. Amylases break down carbohydrates into sugars. Proteases break down proteins into amino acids. And lipases break down fats into fatty acids.

Sometimes the body doesn't make enough digestive enzymes.  

This can happen when the pancreas stops making digestive enzymes in people with diabetes, cystic fibrosis, pancreatic cancer, or chronic pancreatitis (inflammation of the pancreas). 

It can also happen if people don't have enough stomach acid due to medications like antacids or medical conditions like hypothyroidism and stomach cancer.

And people who have had gastric bypass may have a deficiency in digestive enzymes. This surgery removes part of the digestive tract that makes digestive enzymes.

What are the symptoms of digestive enzyme deficiencies?

If your food cannot get broken down properly and pass through your digestive system comfortably, you may experience symptoms like gas, bloating, nausea, stomach pain, heartburn, diarrhea, fatty stools, and fatigue. You may even risk malnutrition because you can't absorb the proper nutrients from your food. In addition, some people have issues with weak bones (insufficient calcium and vitamin D), low red blood cell count (anemia caused by vitamin B12 deficiency), and nerve pain in their feet.

Who needs digestive enzymes?

If you're dealing with uncomfortable digestive symptoms, trying over-the-counter (OTC) digestive enzyme supplements can be easy. But it's not necessary. If you're not deficient, you don't need to take supplements. However, if you lack digestive enzymes, you should supplement the digestive enzymes you don't have. 

You should talk to your healthcare provider first. They will ask you questions about your symptoms and get tests done to reach a possible diagnosis. 

Are natural digestive enzyme supplements safe?

Clinical studies show that natural digestive enzymes may help with symptoms. Still, more studies are needed to prove their effectiveness and safety. They are not risk-free, and some people may experience allergic reactions or interactions with their medications.

OTC products derived from plants, animals, or fungal sources are available. Some products that you may see include papain (from papayas), bromelain (from pineapples), trypsin (from bacteria or fungi or the pancreas of pigs), and alpha-galactosidase (Beano) from fungi. 

Also, kiwis (actinidin), oats (lipase), and honey (amylase) in their raw state have naturally occurring digestive enzymes that break down protein, fat, and sugar, respectively. 

What about BPC 157?

So you've tried everything to heal your gut. You’ve talked to your healthcare provider, and you’ve had tests done to rule out digestive enzyme deficiencies. Then, you've changed your diet. You've focused on eating a diverse range of foods, particularly high-fiber foods, and foods rich in polyphenols. You've limited your intake of artificial sweeteners and take antibiotics only when necessary. You've even tried taking a daily probiotic to help reduce gut inflammation and encourage "good" bacteria to grow. 

No matter what you've tried, you continue to have stomach pain, cramping, gas, or bloating. 

This is where BPC 157 may help. You can find out more information about BPC 157 and gut health at pepties.com. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Today we are talking peptide therapy. What is it? What does it do? 

-So the million-dollar question is what is peptide therapy?

Peptide therapy is the use of lab-made peptides as a means of triggering a specific reaction in your body. 

-Unfortunately, we know that the effects of aging, stress, and changes in our diet can affect our body’s natural production of amino acids. This can result in many negative effects.

Peptide therapy aims to raise low peptide levels that can’t be replaced with supplements to help prevent or treat certain conditions. Pretty cool right? 

With peptide therapy, we can provide the body with a renewed ability to do what it did when we were younger and help our body with restoration and repair. 

Many aspects of our bodies and our health can be improved with peptides.

Did you know that more than 80 FDA-approved peptide drugs (also known as peptide therapeutics) are on the market for conditions like diabetes, cancer, osteoporosis, and multiple sclerosis (MS).

Common peptides are used to help increase your body’s natural human growth hormone (HGH) levels and promote tissue healing in your body. There are other peptides for brain health, sexual wellness, skin health, sleep, mood, concentration and focus, and hair growth.

Most peptides are given as subcutaneous (under the skin) injections. And the great thing about these therapies is you can use them at home. However, oral capsules, topical creams and serums, and intranasal sprays (into your nose) are available. Regardless of the method, it’s important to know that the frequency and dose will differ with each depending on its intended use.

Also…Companies are putting peptides into skin products in the form of serums, creams, and cleansers and dietary supplements are available as powders, capsules, gummies, and liquid shots you can buy at your local pharmacy.

The possibilities are endless! And we are just getting started.

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media And subscribe to our podcast. We’ll see you next time on The Peptide Podcast. Have a happy, healthy week!

Today we’re going to talk about how to eat healthy while taking semaglutide.  This is important because semaglutide should be used with lifestyle changes, including a healthy diet and exercise, to help people lose weight.

What is a healthy diet?

Studies suggest that most diets around the world are energy-rich and nutrient-poor. Let's face it, many foods provide us with calories (energy) without much nutritional value. 

On the other hand, nutrient-rich, whole foods are rich in nutrients and vitamins that are important for health, without too much salt, sugar, or saturated fat. The basic concept of a nutrient-rich, whole-food diet is the amount of nutrients you'll get for the calories consumed.

Think of it this way: You're reading the nutrition labels trying to decide between a quinoa or brown rice package. The rice has about 170 calories per serving but few vitamins and minerals. And although brown rice has less fat per serving, quinoa has more protein, double the fiber, and ten times the amount of folate. It also has more magnesium, potassium, phosphorus, iron, and zinc. So the quinoa option is the more nutrient-rich choice. 

How to Identify Nutrient-Rich Foods?

You’ll want to make nutrition labels your friend. Look for nutrients like calcium, vitamin D, potassium, magnesium, and fiber. Try to avoid added sugars and sodium. 

How to Add Nutrient-Rich Whole Foods to Your Diet 

Try to choose complex carbohydrates because they slowly release sugar into the blood and provide the body with a steady energy supply. Some examples of complex carbohydrates are as follows:

• Quinoa
• Beans/lentils
• Brown rice, barley, oatmeal
• Sweet potato 
• Corn
• Chickpeas

When choosing starchy carbohydrates, whole-grain options are best (e.g., barley, quinoa, millet, oats, brown rice, rye, sorghum, teff, popcorn, and wheat). They are high in fiber and help keep you full for longer, which may contribute to weight management. 

A balanced approach to your diet is important. Your meals should include a variety of fruits and vegetables, whole grains, and healthy sources of protein (legumes, nuts, fresh fish, low-fat dairy, or lean cuts of meat). 

What Foods Should I Avoid?

Try to avoid refined sugars, which are usually found in processed foods. These include foods like packaged snacks, candy, soda, and cereals. These foods may leave you feeling tired and have been linked to weight gain, Type 2 diabetes, and heart disease. 

Sometimes it can be difficult to tell if food is processed. But reading the ingredients can help if you're not sure. If any ingredient listed on the label isn't used in kitchens, it's probably processed food. Examples include fructose, high-fructose corn syrup, maltodextrin, and lactose, to name a few.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

Today we're going to talk about things you can do over time to help boost your immune system and thymosin alpha 1 (TA1), a peptide therapy used for immune support.

Most of us know that there are certain things we can do to limit our exposure to germs that can make us sick. Things like washing our hands with soap and water or hand sanitizer and keeping high-touch areas clean can limit your exposure to germs. 

But there are other things we can do over time to boost our immunity and create a stronger immune system. 

What works to boost our immune system?

A balanced approach to your diet is important. Your meals should include a variety of fruits and vegetables, whole grains, and healthy protein sources (legumes, nuts, fresh fish, low-fat dairy, or lean cuts of meat). 

Try to avoid refined sugars, which are usually found in processed foods. These include foods like packaged snacks, candy, soda, and cereals. These foods can increase inflammation and can dampen a strong immune response. They can also leave you feeling tired and have been linked to weight gain, type 2 diabetes, and heart disease.

Sometimes it can be difficult to tell if food is processed. But reading the ingredients can help if you're not sure. If any ingredient listed on the label isn't used in kitchens, it's probably processed food. Examples include fructose, high-fructose corn syrup, maltodextrin, and lactose, to name a few.

Clinical studies have shown that physical activity affects the immune system. In fact, regular exercise can boost the immune system, provide additional energy, promote restful sleep, and help lower your risk of type 2 diabetes, heart disease, and cancer. It can even help reduce chronic pain and stress, which may help improve your mood. 

But how often should you exercise? The American Heart Association recommends weekly 150 minutes of moderate aerobic activity (e.g., water aerobics, dancing, or gardening) or 75 minutes of vigorous aerobic exercise (e.g., running, swimming laps, or jumping rope). It also recommends two days of muscle-strengthening activities like resistance or weight training, yoga, or pilates.

It's recommended that older adults should also include balance training in their exercise routines (e.g., tai chi, heel-to-toe walking, or balancing on one leg). These exercises improve coordination and stability and may help prevent falls.

Fun fact: Your immune system is activated during sleep. But how much sleep do you need?

Individual sleeping requirements vary depending on age, overall health, medications, underlying sleep disorders, and lifestyle. For example, the National Sleep Foundation recommends that adults ages 18 to 60 get 7 or more hours per night while adults 61 to 64 get 7 to 9 hours per night. If you're 65 years and older, getting 7 to 8 hours of sleep per night is recommended.

Not getting enough sleep may increase inflammation or decrease your immune response. Lack of sleep can also worsen or lead to chronic diseases like depression, diabetes, high blood pressure, heart disease, stroke, and unintentional weight gain. 

Excessive alcohol consumption can weaken the immune system. Alcohol can damage the lining of the gut, causing inflammation, infections, and stomach ulcers. 

A heavier body weight can dampen the immune system and increase the risk of infections. This is because there are fewer infection-fighting immune cells, and excess body fat contributes to inflammation. 

What peptide may help to enhance immune function?

Thymosin alpha 1 (TA1) has been shown to enhance the function of certain immune cells. TA1 has been shown to exhibit antibacterial and antiviral properties, suppress tumor growth, and promote wound and tissue healing. 

TA1 is used for clinical conditions where immune support is needed. Zadaxin is a TA1 peptide evaluated and approved in 30 countries for treating hepatitis B & C, HIV, and AIDS. It's also used with chemotherapy for certain lung, liver, and skin cancer patients. In addition, it is used in people with DiGeorge syndrome and has shown promising results in treating Lyme disease. 

Currently, the medication is in Phase III trials for treating hepatitis C and Phase II trials for hepatitis B in the United States. 

How do I take TA1?

The peptide injection is subcutaneous (injected into the fatty tissue) once daily. For viral infections, treatments usually last for 2 weeks. But, depending on what you're treating and how serious your infection is, treatment could last 3 months or more. The dose depends on why you're taking it.

What are the possible side effects of TA1?

Possible side effects include redness, itching, or swelling at the injection site. As always, you should tell your healthcare provider about any side effects you experience. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Semaglutdie-containing medications (like Ozempic, Wegovy, Rybelsus) have recently made headlines after some reports of gastroparesis. And experts don't know for sure if this side effect is linked to semaglutide itself. 

Keep in mind that several other medications and health conditions can cause gastroparesis. There were no reports of gastroparesis in a 2-year clinical study of semaglutide use in patients with overweight or obesity.

And while semaglutide and other GLP-1 agonists like tirzepatide (Mounjaro, Zepbound) and liraglutide (Victoza, Sexenda) cause stomach-related side effects like nausea, vomiting, upset stomach, diarrhea, and constipation, we know these effects happen because the medications slow down how quickly food leaves your stomach (delayed gastric emptying). 

The good news is that these side effects are reported to be reduced after about 5 months (20 weeks) of use.

In this podcast, we'll discuss gastroparesis, what causes gastroparesis, and how to lower your risk of gastroparesis.

What is Gastroparesis?

Gastroparesis occurs when the stomach muscles fail to function properly, leading to slowed or incomplete movement of food and liquid from the stomach to the small intestine, even though there isn't a blockage. 

This delay can result in digestive issues and discomfort for individuals with gastroparesis. Symptoms include stomach pain, ulcers, and heartburn. You may also experience nausea and vomiting.

What Causes Gastroparesis?

One of the most common causes of gastroparesis is diabetes (T1DM or T2DM). High blood sugar levels over time can damage the vagus nerve, which controls the stomach muscles.

Some individuals may develop gastroparesis as a complication of abdominal surgery, particularly those involving the stomach or intestines.

Certain neurological conditions, such as Parkinson's disease and multiple sclerosis, can affect the nerves that control stomach function, leading to gastroparesis.

It can also be caused by certain medications, including some opioid pain medications, antidepressants like venlafaxine, and allergy medications like diphenhydramine (Benadryl). It can also be caused by viral infections that can damage the stomach nerves and marijuana use.

How can you lower your risk of gastroparesis?

If you have diabetes, you can lower your risk by keeping good control of your blood sugar. You can also avoid medications that can cause gastroparesis. But it's important to know that 40% of gastroparesis cases are idiopathic (unknown reason).

GLP-1 agonists and gastroparesis

Research on semaglutide-induced gastroparesis is limited, but there have been patient reports of gastroparesis with GLP-1 agonists like tirzepatide, liraglutide, and semaglutide. However, the majority of the people who reported gastroparesis symptoms also had diabetes and their gastroparesis resolved after temporarily discontinuing the GLP-1 agonist. In some cases, diet changes (eating small frequent meals that are low in fiber and fat and avoiding carbonated beverages that may bloat the stomach) also helped resolve symptoms.

Keep in mind: We mentioned earlier there were no reports of gastroparesis in a 2 year clinical study of semaglutide use in patients with overweight or obesity. The FDA states that they can't confirm if GLP-1 agonists directly cause gastroparesis or an underlying health condition.

Remember: Gastroparesis symptoms are very similar to common semaglutide side effects. But just because these symptoms occur, it doesn't mean there's a problem. If your symptoms become severe, aren't going away, or worsen, you should let your healthcare provider know. They can help determine what steps you should take next.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Today, we're exploring an incredibly important topic that touches on metabolism, energy, and long-term wellness: how to create an insulin-sensitive lifestyle. I’ve been a strong advocate for understanding how insulin affects our health, and I want to share some amazing tips and strategies that can help anyone improve their insulin sensitivity. So, let’s jump right in!

Segment 1: What is Insulin Sensitivity?

Before we dive into how to improve it, let's first understand what insulin sensitivity is and why it’s so important.

Insulin is a hormone produced by your pancreas that helps regulate blood sugar. When we eat carbohydrates, our blood sugar levels rise, and insulin helps to shuttle that sugar into our cells for energy. However, when we eat too many processed foods, sugars, or unhealthy fats, the body can become “insulin resistant.” This means your cells become less responsive to insulin, and as a result, your body needs to produce even more insulin to manage blood sugar. Over time, this can lead to higher levels of fat storage, especially around the belly, and increase the risk of diseases like Type 2 diabetes.

Improved insulin sensitivity allows your body to efficiently convert glucose into energy, helping to prevent blood sugar spikes and crashes. This leads to more consistent energy throughout the day, keeping you energized and focused.

Better insulin sensitivity plays a key role in reducing the risk of type 2 diabetes, metabolic syndrome, and heart disease. By lessening the burden on your pancreas and decreasing inflammation associated with insulin resistance, it helps protect your long-term health.

People with improved insulin sensitivity are more effective at burning fat for fuel. This helps to reduce fat storage, particularly around the abdomen, making it easier to maintain a healthy weight.

Insulin influences other hormones like cortisol and leptin. By boosting insulin sensitivity, you may experience better appetite control, reduced stress levels, and more restful sleep.

Research indicates that maintaining insulin sensitivity can promote healthy aging and lower the risk of age-related diseases, helping you stay vibrant and active as you age.

Segment 2: Some Key Strategies for Creating an Insulin-Sensitive Lifestyle

1. Focus on High-Quality Whole Foods
Think lean proteins (e.g., grilled chicken, fish, tofu, and eggs), non-starchy vegetables (e.g., leafy greens, cucumber, broccoli), and low-sugar fruits (e.g., berries, watermelon, kiwi). These foods are not only low in carbohydrates but also provide a steady, slow-releasing energy source, which helps maintain stable blood sugar levels.

2. Limit Processed Carbs and Sugars
These foods cause a rapid spike in blood sugar, followed by a crash, which can trigger insulin resistance over time. Avoid foods like soda, baked goods, and other sugary snacks.

Instead, focus on complex carbohydrates like quinoa, sweet potatoes, and legumes, which break down more slowly, keeping blood sugar levels steady.

3. Intermittent Fasting
This practice involves eating within a specific window during the day, for 8 hours, and fasting for the remaining 16 hours. By restricting the eating window, the body can lower insulin levels and improve its sensitivity over time.

Intermittent fasting also helps to regulate other hormones and promotes autophagy, a process that helps the body clear out damaged cells and improve overall health.

4. Focus on Healthy Fats
Healthy fats can help balance insulin levels by providing a stable energy source without causing a blood sugar spike. They also support your body's production of key hormones, including insulin itself.

5. Exercise and Movement
Regular physical activity is another cornerstone of an insulin-sensitive lifestyle. Strength training or resistance training, such as lifting weights or doing bodyweight exercises, can enhance muscle mass, which helps increase insulin sensitivity. Cardiovascular exercise, like walking or swimming, helps the body burn through glucose more efficiently.

Even simple activities like walking after meals can improve insulin sensitivity, as it allows your muscles to use the glucose in your bloodstream rather than storing it as fat.

6. Sleep and Stress Management
Both are crucial components of an insulin-sensitive lifestyle. Poor sleep and chronic stress can raise cortisol levels, making the body more insulin resistant. Prioritizing quality sleep—around 7 to 9 hours per night—and finding ways to manage stress through meditation, yoga, or deep breathing exercises can significantly improve your body’s ability to regulate insulin.

An insulin-sensitive lifestyle isn’t just about following a strict diet or exercise regimen—it’s about taking a holistic approach to your health.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Thank you for your support of the Peptide Podcast. If you’re ready to dive deeper into the world of nutrition, don’t miss Dr. Nikki’s new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. You will find the link in the podcast description…now on to the podcast…

Today we're going to talk about the importance of sleep and different peptide therapy options available to help with sleep. 

Before we talk about why sleep is so important, I think it's necessary to go over what happens during sleep. When we're sleeping, we go through several sleep cycles. And, in each of these sleep cycles, you go through different stages of sleep. 

There are two main stages of sleep: rapid eye movement (REM) and non-rapid eye movement (NREM) sleep. 

After you fall asleep, your sleep cycles will mostly be NREM sleep. During this time, you'll have three sleep phases: two light and a deep sleep phase.  

After you've been asleep for about 6 hours, most of your sleep will be REM sleep. This is the stage when you are dreaming occurs. 

So what is the importance of this?

Deep sleep and REM sleep help your body in different ways. Deep sleep helps your body heal. Research has shown that muscle growth, tissue repair, and growth hormone release occur during deep sleep. It’s also shown that REM sleep is vital for learning new information, brain development, and emotional regulation. 

How much sleep do you need?

Individual sleeping requirements can vary depending on age, overall health, medications, underlying sleep disorders, and lifestyle. The National Sleep Foundation recommends that adults ages 18 to 60 should get 7 or more hours per night while adults 61 to 64 should get 7 to 9 hours per night. If you're 65 years and older, getting 7 to 8 hours of sleep per night is recommended.

Not only is it important to get the correct amount of sleep, but your body also needs quality sleep. But how can you know if you've had good sleep? You can usually define your sleep quality by how you feel the next day. 

If you wake up feeling well-rested, energized, and refreshed, it's likely because you've had quality sleep. 

What can affect sleep quality?

Many things can affect your sleep quality ranging from medical conditions (e.g., chronic pain, anxiety, depression) to the medications you take or just having a stressful day at home or work. But trying to create a sleep-friendly environment by avoiding technology before bed and avoiding caffeine and alcohol before bed may help.

What happens if you don't get enough sleep?

Let's face it. It's normal to have occasional sleepless nights. Maybe you had a stressful day at work, a sick family member, or one too many cocktails at your friend's party. The next day, you wake up feeling groggy and irritated and unable to concentrate at work. The good news is that this feeling shall pass. But for some people, the physical health problems associated with sleeping problems (lack of sleep for 3 months or longer), increase their risk of depression, diabetes, high blood pressure, heart disease, stroke, and unintentional weight gain. They can also have decreased immune function and get sick more often.

What peptides may help with sleep problems?

DSIP (Delta Sleep-Induced Peptide) has been shown to promote delta wave sleep (deep sleep). In studies, disturbed sleep was normalized when injections of DSIP were given. Better performance and increased alertness were seen during awake cycles, along with improved stress tolerance and coping behavior.  

Selank is typically used as an "anti-anxiety" peptide. It does this by enhancing the effects of GABA, thus reducing anxiety. But it also increases serotonin levels. Serotonin influences our appetite and mood and regulates our sleep-wake cycle. Low serotonin levels can lead to depression and insomnia. Therefore, if you take Selank and increase your serotonin levels, you may improve your sleep balance.

As we get older, growth hormone secretion decreases. As a result, it's common for aging people to experience a decline in strength and energy as well as other age-related changes like increased body fat, decreased lean muscle mass, loss of skin elasticity, and poor sleep. Growth hormone-releasing hormones (or GHRHs) like CJC 1295 and Tesamorelin and growth hormone-releasing peptides (GHRPs) like Ipamorelin promote the increase in growth hormone and enhance sleep quality.

Thanks again for listening to The Peptide Podcast; we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

If you're like most people, you've probably heard about collagen supplements or collagen peptides. Many people use collagen supplements to boost skin, hair, and joint health. But does eating foods high in collagen have the same benefits?

Today we're going to talk about a question I get often. What collagen-rich foods help with aging? We'll also discuss some of the negative effects of foods high in collagen and other ways to increase collagen naturally.

The fact is, we make less collagen as we age. So it's no surprise that people turn to collagen supplements for their potential benefits. Who wouldn't want more youthful glowing skin or stronger nails? But taking one more supplement isn't always convenient for some people.

What are collagen peptides?

We've discussed collagen supplements before in the context of their benefits and how to choose which is best for you. And if you remember correctly, collagen supplements are available in many forms, including powders, capsules, gummies, and topical products. 

It's important to remember that whole collagen doesn't dissolve easily. The collagen found in supplements isn't exactly like the collagen found in our bodies. Collagen peptides are hydrolyzed collagen or collagen broken up into smaller pieces so your body can digest and absorb it better. 

It's also important to remember that collagen is only found in humans and animals. So products labeled vegan collagen are labeled incorrectly, and they don't have collagen. Instead, they have ingredients that claim to help the body's natural collagen production. But keep in mind there is currently no research supporting these vegan supplements' effectiveness.

What about collagen-rich foods?

Collagen-rich foods like bone broth, chicken and pork skin, fish, and other seafood might help your body make more collagen.

But these collagen-rich foods like animal and fish skin are high in fat. You need to remember that a diet high in fat has been linked to high cholesterol, inflammation, and a higher risk of heart disease and cancer. 

While this doesn't mean you can't occasionally enjoy roasting a chicken and eating it with the skin on or braising pigs' feet in soy sauce (a very popular Korean dish), I wouldn't suggest eating these dishes for the sake of increasing your collagen. Instead, consider other sources like bone broth which is low in fat and high in vitamins and minerals.

Are there other ways to increase collagen naturally?

Amino acids like glycine, proline, and lysine may help your body make more collagen. They can be found in eggs, beans, wheat, dairy products, seaweed, and natto (fermented soy). Other nutrients that have been linked to collagen production include vitamin C, vitamin E, vitamin A, and copper. 

Good vitamin C sources include guava, papaya, citrus fruits, and mango. It also includes vegetables like red and green peppers and broccoli.

Good sources of vitamin E include green leafy vegetables, nuts, and seed oils like sunflower and safflower oil. But remember that seed oils should be used in moderation as part of an overall balanced nutrition plan that includes many vegetables, fruits, and lean proteins.

Good sources of vitamin A include sweet potatoes, spinach, carrots, red bell peppers, broccoli, beef liver, and fruits like cantaloupe and mango. 

You can find out more information about collagen and collagen supplements at pepties.com. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We discussed semaglutide a while back, and a lot of you had some good questions. Today we’re here to answer those questions. 

How fast does semaglutide work? The short answer is that many people will lose weight in the first week of taking semaglutide if they make lifestyle changes (e.g., increased physical activity and reduced-calorie diet). Remember, the first 4 doses are small and are primarily used to gently introduce the peptide to the body without risking stomach-related side effects. It’s important to understand that it’s possible to “out-eat” any weight loss medication. So, you may see little to no weight loss in the early weeks without making lifestyle changes. 

How fast can you increase the semaglutide dose? Typically the dose of semaglutide is increased once every 4 weeks. For example, you would receive one month (4 prefilled syringes) of 0.25mg, then one month (4 prefilled syringes) of 0.5mg, and so forth, assuming your side effects are not bothersome. 

If you don’t tolerate a dose during dose escalation due to bothersome side effects, your healthcare provider may consider delaying a dose increase for 4 weeks. 

How much weight will I lose with semaglutide? Healthy, sustainable weight loss is 0.5 to 2 pounds per week. Some people routinely lose more than this. Remember that a 68-week study with almost 2,000 adult participants reported an average weight loss of nearly 15% of their body weight (approximately 35 pounds) on semaglutide. The placebo group lost an average of 2.5% of their body weight. 

Will I have to take semaglutide forever? The answer to this is complicated and depends on the person. The short answer is no. 

Nutrition, physical activity, and good-quality sleep are essential for weight loss. And unfortunately, stress can also impact your ability to maintain a healthy weight. Semaglutide is helpful but may only be necessary for a while if you can adopt lifestyle changes and continue to use them after you stop semaglutide. 

Where can I inject semaglutide? You can inject semaglutide into the fatty tissue of your upper arms, stomach, or upper legs.

What if I accidentally skip my semaglutide dose? If you miss a dose of semaglutide and your next scheduled dose is less than 2 days (48 hours) away, do not give yourself the dose. Instead, take your next dose on your regularly scheduled day.

Where should I store my semaglutide? Semaglutide should be stored in the refrigerator.

*The important thing to keep in mind is that the benefits of semaglutide are much more than looking and feeling good. By losing or maintaining a healthy weight, you’re also likely to improve the overall quality of your life.

While your weight should not define you, it’s no secret that there are many benefits to keeping a healthy weight. Unfortunately, several health risks are associated with being overweight.

Research has shown that there are several risks associated with excess weight. These include: 

• Joint and muscle pains
• Energy problems
• High blood pressure
• High cholesterol
• Sleep problems
• Blood clots and stroke
• Fertility problems
• Erectile dysfunction in males
• Several types of cancers (e.g., colon, kidney, esophagus, endometrium, and breast cancer)
• Complications in pregnancy and childbirth
• Complications in surgeries

So whatever your goal is, weight loss is certainly important for your health. If you’ve made changes to the way you eat and have increased your physical activity but still struggle to lose weight, semaglutide may be an option for you.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

Peptide lip tints are cosmetic products designed to enhance the appearance of lips while also providing hydration and potential anti-aging benefits through the use of peptides. Peptides are short chains of amino acids that can have many effects on the skin, including promoting collagen production, improving skin elasticity, and reducing the appearance of fine lines and wrinkles.

These little tubes of magic have taken the beauty scene by storm, offering a perfect fusion of skincare and makeup in one product. But what exactly makes peptide lip tints the latest obsession? 

In this podcast, we’ll talk about some key points to consider regarding peptide lip tints and uncover the allure behind these coveted products.

1. Lip Enhancement:

Peptide lip tints often contain ingredients that temporarily plump the lips, giving them a fuller appearance. These ingredients may include hyaluronic acid or other moisturizing agents (e.g. cupuaçu) that attract water to the lips, causing them to swell slightly.

2. Hydration:

Many peptide lip tints contain moisturizing ingredients like shea butter, cocoa butter, or various oils (e.g., babassu oil) to keep the lips hydrated and prevent dryness and chapping. Hydrated lips can appear smoother and more youthful.

3. Anti-Aging Benefits:

Peptides included in lip tints may offer anti-aging benefits by stimulating collagen production in the lips. Collagen is a protein that provides structure and firmness to the skin, and increased collagen production can help reduce the appearance of fine lines and wrinkles around the lips.

4. Tinting:

Peptide lip tints often come in various shades to provide a subtle tint to the lips, enhancing their natural color. The tint may be achieved through pigments or natural dyes, and it can help create a polished look without the need for additional lip products.

5. Long-Term Effects:

While peptide lip tints may provide immediate benefits like hydration and lip enhancement, their long-term effects on lip health and appearance may vary. Consistent use over time may help maintain the lips' hydration and potentially contribute to anti-aging effects, but individual results can differ.

Do peptide lip tints and balms work?

As with any cosmetic product, the effectiveness of peptide lip tints can depend on individual preferences and skin types. Some people may notice significant improvements in lip appearance and hydration, while others may experience more subtle effects. It's important to choose products that suit your preferences and skin needs.

Keep in mind that peptide lip tints can be relatively expensive compared to traditional lip balms due to several factors, such as ingredients, brand reputation, packaging, and research and development.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Welcome to The Peptide Podcast! We’re talking about the peptide info you need to know to start your week in less than 2 minutes! Simple, Fast, and Fun. 

Today we are talking peptides and amino acids. 

- What are peptides?

There is a lot of buzz about peptides and what they can do for your skin, joints, muscles, and overall health. But, what exactly are they?

Your body makes peptides. They are found in every cell and tissue. Think of peptides as nothing more than short chains of amino acids. Well, what’s an amino acid?

-Amino acids are molecules that combine to form proteins in your body. 

It’s important to remember that peptides and proteins are not the same. Peptides are tiny messengers that deliver instructions to your cells to perform certain processes. They are like a key. And each and every function within our body requires a key to take place. So peptides are this key that has a specific job. 

When proteins are digested or broken down, amino acids are left. The human body uses amino acids to help the body to do things like:

• Break down food
• Build muscles and grow
• Repair tissues
• Make hormones and brain chemicals 
• Cell building
• Boosting the immune system 

Amino acids can also be used as a source of energy by the body.

*There are 20 amino acids that combine to make protein found in the  body and they are classified into two groups:

• Essential amino acids
• Nonessential amino acids

ESSENTIAL AMINO ACIDS

• Essential amino acids can’t be made by the body. So they have to come from somewhere… We get these amino acids from our food.
• There are 9 essential amino acids. 

NONESSENTIAL AMINO ACIDS

The name is very misleading because we DO need these amino acids. They perform ESSENTIAL roles, but since they’re made by your body, they’re not an essential part of your diet. 

The easiest way to think of this is that you still can get nonessential amino acids from food. You just don’t need to worry about getting enough of these amino acids, since your body will make the amino acids and fill in any gaps not met by your diet. 

There are 11 Non-essential amino acids. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media. Leave us a comment if you like. Subscribe to our podcast. And we’ll see you next time on The Peptide Podcast. Have a happy, healthy week!

Alzheimer's disease is a type of dementia characterized by memory loss, cognitive decline, and a decline in the ability to perform daily tasks (e.g., planning and organizing). It can also affect mood and personality and impair judgment and language. Research has shown that Alzheimer’s results from amyloid plaques and neurofibrillary tangles in brain tissue, which affect communication between brain neurons. 

The quest for effective treatments remains a high priority. Among the promising therapeutic avenues being investigated, GLP-1 (glucagon-like peptide-1) agonists, traditionally used for managing type 2 diabetes and weight, have garnered significant attention for their potential benefits in Alzheimer's disease. In this podcast, we’ll discuss the potential use of GLP-1 agonists in Alzheimer’s disease and how they work.

Understanding GLP-1 Agonists

GLP-1 agonists are a class of medications primarily used to enhance insulin secretion and improve glycemic control in patients with type 2 diabetes and obesity. They mimic the effects of the natural hormone GLP-1, which is involved in glucose metabolism and appetite regulation. Besides their glucose-lowering properties, GLP-1 agonists have been observed to have various effects beyond glucose control, including neuroprotective properties.

Mechanisms of Action of GLP-1 Agonists in Alzheimer's Disease

1. Neuroprotection: GLP-1 agonists have been shown to exert neuroprotective effects in preclinical models of Alzheimer's disease. They may help protect neurons from damage and death, which is crucial in a disease characterized by widespread neuronal loss. The mechanisms through which GLP-1 agonists provide neuroprotection include reducing oxidative stress, inflammation, and apoptosis (cell death).

2. Amyloid Beta and Tau Pathology: Alzheimer's disease is marked by the accumulation of amyloid beta plaques and tau tangles in the brain. Some studies suggest that GLP-1 agonists might influence the pathology associated with Alzheimer's disease by reducing amyloid beta deposition and tau phosphorylation. While these effects have been observed in animal models, translating these findings to human patients requires further research.

3. Cognitive Function: Clinical trials and studies have explored the impact of GLP-1 agonists on cognitive function in Alzheimer's patients. Preliminary results are promising, with some research indicating that GLP-1 agonists may improve cognitive function and slow cognitive decline. This effect is thought to be linked to the drugs’ ability to enhance neurogenesis (the formation of new neurons) and synaptic plasticity (the ability of synapses to strengthen or weaken over time).

4. Metabolic Regulation: Alzheimer’s disease has been associated with metabolic dysfunctions, including insulin resistance and impaired glucose metabolism. GLP-1 agonists, by improving insulin sensitivity and glucose regulation. This might address some of these metabolic abnormalities, potentially offering an additional benefit in managing Alzheimer’s disease.

Clinical Evidence and Future Directions

Research into the use of GLP-1 agonists for Alzheimer’s disease is still in its infancy, and larger, well-designed clinical trials are needed to confirm their efficacy and safety in this new context.

Moreover, while GLP-1 agonists show promise, they are not without side effects, including stomach-related side effects such as nausea, diarrhea, and constipation. As such, their use in Alzheimer’s disease will require careful consideration of the risk-benefit profile for individual patients.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Hey, welcome back! Today, we’re diving into something that can seriously up your game when it comes to energy, performance, and even longevity—NAD+. If you haven’t heard of it, don’t worry, we’ve got you covered.

We’re also going to talk about some awesome peptide stacks that can keep you feeling energized and performing at your best—whether that’s crushing it in your workouts or staying sharp through your workday grind.

So, if you’re looking to boost your fitness, stay more focused at work, or just feel more energized in general, this episode’s for you.

What is NAD+?

Alright, let’s kick things off with the basics—what is NAD+? It stands for Nicotinamide Adenine Dinucleotide, which is a bit of a mouthful, but it’s actually a co-enzyme that’s super important for energy production in your body. Think of it as the fuel for your cells. Without NAD+, your cells can’t make energy, which is obviously a big deal.

Now, here’s the thing—our NAD+ levels drop as we get older. This can lead to feeling tired, slower recovery, and just a general lack of energy.

But don’t panic—there’s good news! Supplementing with NAD+ (either through injections or IV infusions) or even helping your body boost its NAD+ production naturally can actually reverse some of these aging effects. Not only will you feel more energized, but you’ll also get benefits like improved focus, better endurance, faster recovery, and even some anti-aging perks.

How Does NAD+ Work?

So, how does NAD+ actually work in the body? It plays a huge role in energy production by helping with mitochondrial respiration. Basically, it cycles between two forms—NAD+ and NADH—to help produce ATP, which is the energy currency of your cells.

But that’s not all. NAD+ also impacts proteins called sirtuins that regulate metabolism, stress responses, and longevity. It even activates enzymes like PARPs that help with DNA repair, which is key for maintaining cell integrity, especially when dealing with things like aging and stress.

And on top of that, NAD+ is involved in cell signaling pathways that influence things like inflammation, insulin sensitivity (which could help with weight management), and even your circadian rhythm.

What Are the Benefits of NAD+?

So, you’ve got energy, anti-aging, and DNA repair—but that’s just the start. NAD+ can also help with memory, focus, and mental clarity by keeping your neurons healthy and protected from neurodegeneration.

In fact, there’s some research showing that NAD+ therapy could even help with managing withdrawal symptoms and cravings, particularly for alcohol and opioid dependencies.

Are There Any Side Effects of NAD+?

Like anything, NAD+ therapy can have some side effects, though it’s generally considered safe. Some people may experience things like low blood pressure, flushing, nausea, headaches, or fatigue, especially after an injection. But the good news is these side effects tend to go away on their own, and over time, your energy levels will start to improve.

Let’s Talk About Stacking NAD+ for Even More Benefits

Okay, so you’re probably wondering how to make the most of NAD+. Well, stacking it with the right supplements can seriously amplify its effects. But it’s not just about throwing a bunch of stuff together and hoping for the best. You’ve got to have the right combos to really level up your energy, endurance, and focus.

Here are my top four NAD+ stacks:

1. NAD+ + Glutathione
   This stack is great for detoxing and reducing oxidative stress. It supports your cellular health and helps fight free radicals, which is key for feeling good and staying healthy long-term.
   
   

2. NAD+ + 5 Amino-1MQ
   If you’re looking to support metabolic health and fat loss, this one’s for you. 5 Amino-1MQ is a peptide that works really well with NAD+ to boost fat-burning and improve metabolic efficiency.
   
   

3. NAD+ + Thymosin Alpha-1
   Thymosin Alpha-1 is a peptide that’s all about boosting your immune system. When combined with NAD+, it enhances your immune-regulating effects, making it a powerful duo for longevity and immune resilience.
   
   

4. NAD+ + Epitalon
   Epitalon is a peptide that helps with telomere health, which is essential for anti-aging. When paired with NAD+, it supports cellular repair and overall longevity.
   
   

If you’re thinking about adding NAD+ to your routine, I’d recommend starting with a high-quality supplement. Take it consistently, pair it with the right stacks, and give it a bit of time to work its magic.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Cerebrolysin – a unique peptide-based drug that has garnered attention for its potential brain-boosting effects. In this podcast, we'll cover Cerebrolysin, understanding what it is, how it works, and its potential benefits in optimizing brain function.

What is Cerebrolysin?

Cerebrolysin is a nootropic drug developed and manufactured by Ever Pharma, a pharmaceutical company based in Austria and Germany. It's a mix of peptides originally derived from pig brain tissues and processed to create a peptide-based solution rich in neurotrophic factors. These neurotrophic factors are essential proteins that support neurons' growth, survival, and maintenance, aiding in their communication and overall brain health.  

*The FDA has approved it as an orphan drug (for use in rare disorders like ALS and frontotemporal dementia). However, it's widely used in over 70 countries worldwide.

How Does Cerebrolysin Work?

The exact mechanism of Cerebrolysin's action is not entirely understood, but it is believed to work through multiple pathways to promote brain health and cognitive function.

• Neurotrophic Effects: Neurotrophic factors in Cerebrolysin stimulate neuronal growth, maintenance, and repair. These factors aid in forming new connections between neurons, enhancing synaptic plasticity, and improving overall brain connectivity.

• Antioxidant Properties: Cerebrolysin has demonstrated antioxidant activity, neutralizing harmful free radicals in the brain that can damage cells and impair cognitive function. By reducing oxidative stress, it supports brain cells' longevity and health.

• Anti-Apoptotic Effects: Apoptosis is a process of programmed cell death. Cerebrolysin has shown anti-apoptotic properties, protecting neurons from premature cell death and preserving brain tissue.

• Anti-Inflammatory Actions: Chronic inflammation in the brain can be detrimental to cognitive function. Cerebrolysin exerts anti-inflammatory effects, potentially mitigating neuroinflammation and its negative impact on the brain.

• Enhanced Blood Flow: Improved cerebral blood flow is crucial for delivering essential nutrients and oxygen to brain cells. Cerebrolysin has been shown to increase blood flow, supporting the brain's metabolic demands.

What are the benefits of Cerebrolysin?

• Cognitive Enhancement: Cerebrolysin's neurotrophic effects contribute to improved memory, learning, and overall cognitive performance. It mainly benefits individuals experiencing cognitive decline due to aging or certain neurodegenerative conditions.

• Neuroprotective Effects: The drug's antioxidant and anti-apoptotic properties help protect brain cells from damage and death, potentially slowing down the progression of neurodegenerative disorders like Alzheimer's and Parkinson's disease.

• Stroke Recovery: Cerebrolysin has shown promise in aiding stroke recovery. By supporting neuronal repair and enhancing blood flow, it may aid in rehabilitating neurological function after a stroke.

• Traumatic Brain Injury (TBI) Support: In cases of TBI, Cerebrolysin's neuroprotective effects may assist in reducing damage to brain tissue and promoting recovery.

• Mood Enhancement: Some studies suggest that Cerebrolysin may have mood-enhancing effects, potentially helping individuals with mood disorders or depression.

How do you take Cerbrolysin?

Cerebrolysin is typically administered through intramuscular (IM) or intravenous (IV) injections. The dosage and duration of treatment vary depending on the individual's condition and the physician's assessment. Typically given over 2-4 weeks. Repeat doses are based on clinical response and underlying diagnosis.

Indications: Stroke, TBI, Vascular Dementia, and Alzheimer's Disease. You can think of this for clinical syndromes that contribute to brain inflammation and oxidative stress. 

Is Cerbrolysin safe to take?

As with any medication, Cerebrolysin may cause side effects in some individuals. Common side effects include headaches, dizziness, sweating, and nausea. Mild allergic reactions at the injection site can also happen. Serious adverse effects are rare, but if experienced, immediate medical attention is necessary.

Who shouldn't take Cerebrolysin?

- Pork allergy or cultural objection 

- Unstable seizure disorder 

- Severe kidney impairment

If you or a loved one are considering Cerebrolysin as a treatment option, consult a qualified healthcare professional to determine its suitability and safety for your specific needs. As science advances, the quest for unlocking the full potential of the human brain remains a fascinating journey, with Cerebrolysin paving the way for new possibilities in the field of neuropharmaceuticals.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. 

What's the difference between Wegovy and Ozempic? Both Wegovy and Ozempic have the same active ingredient: semaglutide. 

Wegovy is an FDA-approved, once-weekly injectable weight management medication that's been studied in people who do and do not have type 2 diabetes. One reason there's a lot of buzz around semaglutide for weight management is the amount of weight people lost during clinical trials. 

During a 68-week trial with about 2,000 people, adults taking Wegovy lost nearly 15% (approximately 35 pounds) of their starting body weight on average. The placebo group lost an average of 2.5% of their body weight. 

Ozempic is approved to treat type 2 diabetes. In fact, during clinical trials, people taking Ozempic lowered their average blood glucose (A1C) by over 1%. And, if you have heart disease, it may lower your risk of having a heart attack or stroke. 

So how are Wegovy and Ozempic different?

Different people qualify for Wegovy and Ozempic based on certain criteria. For example, Wegovy is approved for adolescents ages 12 and older, while Ozempic may be used in adults 18 or older. 

Adults and adolescents who meet certain BMI criteria may be eligible for Wegovy. This includes adults with a BMI of 30 or more or a BMI of 27 or more with at least one weight-related condition like high blood pressure, type 2 diabetes, or high cholesterol. Adolescents 12 and older must have a BMI at or above the 95th percentile or greater for their age and sex. 

Wegovy and Ozempic are also dosed differently. When you first start taking Wegovy or Ozempic, your healthcare provider will slowly raise your dose to minimize the potential side effects of the medication. 

A typical Wegovy and Ozempic dosage schedule starts at 0.25 mg weekly for 4 weeks and increases if tolerated. But, the maximum dosages of Wegovy and Ozempic are different, 2.4 mg and 2 mg, respectively. 

Why is semaglutide dosed higher for weight loss?

Ozempic was initially approved in 2017 to help control blood sugar in people with Type 2 diabetes. During this time, it was found that people taking Ozempic to help control blood sugar also lost weight. Because of this, the manufacturer of the medication studied semaglutide in people without Type 2 diabetes, but at a higher dose. 

Based on their weight loss findings, the FDA-approved semaglutide (under the brand name Wegovy) for weight loss.

How fast do Wegovy and Ozempic work?

The short answer is that many people will lose weight in the first few weeks of taking Wegovy if they make lifestyle changes. You also want to keep in mind that the first 4 doses are small, and it takes about 20 weeks to reach the target dose. It's also important to remember that you can "out-eat" any weight loss medication. So without the proper lifestyle changes, you may see little to no weight loss in the first few weeks or at all. 

Ozempic also has a low starting dose. This gently introduces the medication to the body without risking stomach-related side effects. Although this starting dose isn't effective for blood sugar control, you may see a benefit to your blood sugar levels when the dosage is increased after the first 4 weeks. 

Will I have more side effects with Wegovy?

This depends. When taking medications that have semaglutide, you may experience stomach-related side effects like nausea, vomiting, or diarrhea. 

Some side effects can be bothersome and make medications like Wegovy or Ozempic difficult to take. Remember, side effects can happen to anyone using semaglutide, but not everyone experiences them the same way. And they tend to be reported more often with higher doses. 

Because Wegovy is usually given at a higher dosage, side effects may be more likely with Wegovy. The good news is they typically go away with time.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Have you ever reached for a bag of chips or a pint of ice cream when you're feeling sad, stressed, or bored? Many of us turn to food as a source of comfort or distraction at some point in our lives — to deal with our feelings or to reward ourselves. This is what's known as emotional eating. And, unfortunately, emotional eating doesn't fix emotional problems.

And, if you've ever thought about food all day, tried to avoid unhealthy food, or found yourself planning your next meal, you've experienced "food noise." 

Today, I want to talk about emotional eating and food noise, understanding their impact on our relationship with food, and how we can develop healthier habits.

What is emotional eating?

Emotional eating refers to using food as a coping mechanism for dealing with emotions rather than eating in response to physical hunger. Some people prefer certain foods when they become emotional. And people who emotionally eat can sometimes eat larger portions than they would like to.

What causes emotional eating?

Coping mechanism: Several studies have shown that a link between emotions and food starts early in life. When we're babies, we are given food (e.g., breastmilk, formula, and cereal) as a source of comfort. When we eat, a chemical in the brain called dopamine is released that causes us to feel good. So it shouldn't be surprising that food can be addicting or comforting for some people. 

But remember, this relief from negative emotions is short-lived and can lead to feelings of guilt, regret, or even worsening emotional states. 

Emotional Triggers: Emotional eating is often triggered by emotions such as stress, relationship struggles, frequent dieting, lack of sleep, depression, anxiety, boredom, or even celebrations and happiness. These emotions can lead us to seek comfort or distraction in food, as it provides a temporary sense of control.

Comfort Food: Emotional eating involves consuming "comfort foods" typically high in calories, fat, or sugar. These foods are often associated with positive memories or feelings of nostalgia, which further enhances their appeal during emotional moments.

What is food noise?

Food noise, simply put, is a preoccupation with food. It could be thoughts about food and eating, like meal planning, looking up recipes, reading menus, avoiding unhealthy foods, or thinking about stopping eating. 

How do I cope with emotional eating?

It's important to recognize your triggers and ask yourself why you're emotionally eating. Before eating, ask yourself if your body is physically hungry. 

Emotional Awareness: Recognize and acknowledge your emotions without turning to food as the primary coping mechanism. Find alternative ways to deal with stress or negative emotions, such as engaging in physical activity, talking to a friend, or practicing relaxation techniques. You can also read or listen to music.

Mindful Eating: Practice mindful eating by paying attention to physical hunger cues, savoring each bite, and eating slowly. You should pay attention to things like flavor and texture. And check in with yourself while eating to see if you are hungry or full. This can help you become more attuned to your body's needs and make conscious choices about what and how much you eat.

How do I cope with food noise?

Avoid getting hungry: Stock your pantry and fridge with nutritious foods, and limit the presence of highly processed and calorie-dense foods. Start your meal with a lean protein source and vegetables.

Get enough sleep: Too little sleep leads to higher levels of ghrelin (a gut hormone that stimulates appetite) and lower levels of leptin (a hormone released by your fat cells that suppress your appetite). 

Seek Professional Help: If emotional eating or food noise becomes a persistent challenge and significantly impacts your well-being, consider seeking support from a registered dietitian, therapist, or counselor. They can provide personalized guidance and help you develop coping strategies.

What about GLP-1 medications like semaglutide?

It's a fact that many of us have an unhealthy relationship with food, which can lead to emotional eating or food noise. And it's only common sense that we need to fix that relationship, adopt healthy lifestyle changes, and better understand what's going on in our bodies if we want to optimize our health.

GLP-1 medications like semaglutide aren't for everyone. But they can be life-changing for people where they're clinically appropriate. 

When you're not hungry all of the time, it's much easier to focus on nutrition, regular exercise, stress management, and getting good quality sleep.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community.

If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. 

Two of the most promising treatments for obesity in recent years are semaglutide, a GLP-1 agonist, and tirzepatide, a dual GLP-1/GIP agonist. These peptides have garnered attention for their impressive efficacy in weight loss and metabolic improvement, but they differ in their mechanisms, dosing, side effects, and outcomes. In this podcast, we'll explore how these peptides compare.

Semaglutide and tirzepatide work in similar but slightly different ways for weight loss

Semaglutide works by mimicking glucagon-like peptide-1 (GLP-1), a hormone that is naturally released by the gut in response to food. GLP-1 helps regulate appetite by increasing the feeling of fullness (satiety), slowing gastric emptying, and reducing the body's insulin resistance. It also stimulates insulin secretion, which helps control blood sugar levels, making it useful not only for weight loss but also for managing type 2 diabetes.

Tirzepatide activates both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors. GIP is another hormone involved in insulin secretion, but it also plays a role in fat metabolism. By engaging both receptors, tirzepatide has a dual/additive impact: it not only boosts insulin sensitivity and appetite suppression (similar to semaglutide) but also enhances the body's ability to process fat and use it for energy — providing an added benefit for weight loss and metabolic health.

Tirzepatide may result in greater weight loss compared with semaglutide

Semaglutide has been shown to reduce body weight by 10-15% in most clinical trials, with some patients achieving even greater weight loss (up to 17% of total body weight). Additionally, it has proven effective in reducing blood glucose levels and improving insulin sensitivity, making it a great option for patients with type 2 diabetes and obesity.

Tirzepatide has shown superior weight loss efficacy, with reductions of up to 20-25% of body weight in clinical trials. Its dual action on GLP-1 and GIP receptors may explain this enhanced efficacy. It also offers significant improvements in metabolic markers, including better glucose control and insulin sensitivity, which can especially benefit patients with obesity-related metabolic disorders (e.g., type 2 diabetes and polycystic ovary syndrome)

Semaglutide and tirzepatide have different doses

Semaglutide is typically administered as a once-weekly injection. The dosing for weight loss starts at 0.25 mg per week and gradually increases in 4-week intervals to a maintenance dose of 2.4 mg per week. The gradual titration helps minimize side effects such as nausea. Sometimes, the semaglutide dose may be increased sooner than the 4-week interval based on the person’s response to the peptide.

Tirzepatide is also administered as a once-weekly injection. The dosing for weight loss starts at 2.5 mg per week and gradually increases to a maintenance dose of 5 mg to 7.5 mg per week, with some people requiring higher doses (10 mg, 12.5 mg, or 15 mg). The dose is generally increased based on patient tolerance, similar to semaglutide but shouldn’t be increased sooner than 4 weeks. 

Semaglutide and tirzepatide have similar side effects

Common side effects of semaglutide include:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Headache

• Tiredness

These stomach-related side effects are usually temporary and go away on their own as the body adjusts to the medication. However, some people may experience more severe symptoms, necessitating a lower dose.

Tirzepatide shares many of the same side effects as semaglutide, including:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Burping

• Flatulence

• Indigestion

Keep in mind:  Tirzepatide's side effects can sometimes be more pronounced, particularly during the dose-escalation phase. Some patients may also experience signs of low blood sugar, especially if used in combination with insulin.

Semaglutide may be a better option if you have heart disease

In March 2024, semaglutide received additional FDA approval for reducing cardiovascular risk in adults with heart disease who are overweight or obese. Clinical studies show that semaglutide reduced the risk of major adverse cardiovascular events—such as heart attack, stroke, or cardiovascular death—by 20%.

Tirzepatide is currently being studied for similar cardiovascular benefits.

Semaglutide and tirzepatide may have benefits for other health conditions

Semaglutide has demonstrated positive outcomes in certain people with heart failure, and a recent study suggests potential kidney-related benefits for those with heart disease. It is also being studied as a treatment for metabolic dysfunction-associated steatohepatitis (MASH), also known as non-alcoholic steatohepatitis, a condition caused by excess fat accumulation in the liver.

Tirzepatide has shown promise for individuals with moderate-to-severe obstructive sleep apnea and may receive approval for this use by late 2024. Additionally, it is under investigation for potential benefits in cardiovascular risk reduction, heart failure, MASH, and chronic kidney disease.

In summary:

• Mechanism: Semaglutide targets only GLP-1, while tirzepatide activates both GLP-1 and GIP receptors.

• Efficacy: Tirzepatide has demonstrated superior weight loss results compared to semaglutide.

• Side Effects: Both drugs have similar stomach-related side effects, though tirzepatide may be more potent and have a higher incidence of certain symptoms.

• Dosing: Both are administered as weekly injections, but their doses differ.

Ultimately, the choice between these therapies will depend on individual patient needs, tolerance, and response to treatment. 

Someone might choose tirzepatide over semaglutide for weight loss due to its greater efficacy in achieving higher levels of weight reduction and its dual mechanism that offers additional metabolic benefits. Others choose to switch from semaglutide to tirzepatide if they hit a weight loss plateau despite changing nutrition and physical activity habits.

When it comes down to it, it’s a personal choice. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Today we'll talk about a question I get asked a lot. Is it safe to take metformin with semaglutide? 

The short answer: It depends. But before we dive into how taking metformin and semaglutide together may affect you, I'd like to go over why someone might be prescribed both semaglutide and metformin.

Semaglutide (Ozempic) and metformin are prescribed to help people with type 2 diabetes manage their blood sugar. However, semaglutide (Wegovy) can also help people manage their weight, especially when used in addition to healthy lifestyle changes like diet, regular exercise, and stress management. Metformin is also prescribed to help treat some symptoms of polycystic ovary syndrome (PCOS), like insulin resistance, irregular menstrual cycles, obesity, and increased hair growth. 

Can I take metformin and semaglutide together for weight loss?

The short answer is yes. In fact, when prescribed together, the medications help manage blood sugar levels. Type 2 diabetes, obesity, and PCOS have been linked to insulin resistance. In this condition, the body doesn't respond appropriately to insulin, leading to high blood sugar and weight gain. Semaglutide stimulates insulin secretion from the pancreas to lower blood sugar and reduce appetite; metformin improves insulin sensitivity. 

There's no interaction between metformin and semaglutide. Both medications are considered safe when taken as instructed. Still, it's important to remember that taking semaglutide with blood-sugar-lowering medications like metformin can raise the risk of low blood sugar (hypoglycemia).  

If you have type 2 diabetes and you've been prescribed metformin to help manage your blood sugar, it's important to regularly check your blood sugar levels to help avoid low blood sugar. Your healthcare provider may also suggest that you have an emergency glucagon product or carry glucose tablets to raise your blood sugar quickly if severe low blood sugar happens. Signs of low blood sugar include feeling shaky, having a fast heartbeat, sweating, confusion, dizziness, or feeling hungry. 

They may also lower your metformin dose to decrease your risk of low blood sugar. 

Although rare, low blood sugar can happen if you take semaglutide alone. But this typically doesn't happen because semaglutide tells your body to release insulin in response to food. 

What about side effects?

When taken together, the side effects are typically the same as those experienced when taking the medications on their own. We've discussed the common side effects of semaglutide before, but I'd like to review them again.

The common side effects of semaglutide are stomach-related (nausea, vomiting, diarrhea, constipation, burping, and bloating) and usually occur with dose increases and go away with time. And some people experience headaches and fatigue. 

Similar to semaglutide, most people experience stomach-related side effects like diarrhea, nausea, vomiting, and gas. 

What about alcohol use?

A couple of weeks ago, we discussed how the occasional alcoholic beverage is okay with semaglutide. But it's important to remember that you may be at risk for pancreatitis and kidney problems with long-term, heavy alcohol use. This risk is higher for dehydrated people due to fluid loss from side effects like nausea, vomiting, or diarrhea. 

Like semaglutide, heavy alcohol use should be avoided while taking metformin as it can increase the risk of developing a condition called lactic acidosis. Lactic acidosis is when too much lactic acid is in our blood, and our organs cannot function properly. This is considered a medical emergency. Symptoms of lactic acidosis include trouble breathing, stomach pain, and muscle aches. 

Oddly enough, you may have heard that semaglutide can may alcohol less appealing for people taking it. In other words, you may not even want to drink alcohol while taking semaglutide. This is likely because when you drink alcohol, a chemical called dopamine is released. Typically, dopamine makes you feel good. But when you take semaglutide, glucagon-like peptide-1 (GLP-1) agonist targets areas in the brain that block the dopamine boost. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier

In the quest for effective weight management, we often focus on diet and exercise, overlooking an important aspect of our health: sleep. Yet, emerging research highlights the profound impact that sleep—or lack thereof—has on our body composition and overall weight. 

From hormonal regulation to appetite control, sleep plays an essential role in shaping our metabolism and influencing our dietary choices. In this podcast, we’ll talk about the reasons why sleep is so important for weight management and how prioritizing quality sleep can support your health goals.

Hormonal Balance

Sleep is intricately linked with hormonal regulation, particularly hormones that regulate appetite and satiety. Leptin, the hormone responsible for signaling fullness, decreases with sleep deprivation, leading to increased hunger and overeating. On the other hand, ghrelin, the hormone that stimulates appetite, rises with sleep loss, further exacerbating cravings and promoting weight gain.

Metabolic Efficiency

Adequate sleep is essential for maintaining metabolic health and efficient energy utilization. Sleep deprivation disrupts glucose metabolism, leading to insulin resistance and impaired glucose tolerance. Consequently, the body's ability to regulate blood sugar levels becomes compromised, increasing the risk of weight gain and metabolic disorders like type 2 diabetes.

Brain Function and Decision-Making

Sleep deprivation impairs cognitive function, decision-making, and impulse control, all of which are important for making healthy food choices. When sleep-deprived, people are more likely to opt for calorie-dense, high-carbohydrate foods, seeking quick energy fixes to combat fatigue. This propensity towards unhealthy eating habits can contribute to weight gain over time.

Muscle Recovery and Repair

Quality sleep is important for optimal muscle recovery and repair, particularly after physical activity. During sleep, the body undergoes essential repair processes, including protein synthesis and tissue regeneration. Inadequate sleep compromises these processes, hindering muscle recovery and potentially impairing exercise performance, which is crucial for weight management.

Stress Management

Chronic sleep deprivation activates the body's stress response, leading to elevated levels of cortisol, the stress hormone. Increased cortisol levels are associated with abdominal fat accumulation and metabolic dysfunction, contributing to weight gain and obesity. Prioritizing sleep helps lower stress and supports a healthier hormonal balance, facilitating better weight management outcomes.

Regulation of Circadian Rhythms

Our bodies operate on internal biological clocks known as circadian rhythms, which regulate various physiological processes, including metabolism and appetite. Disrupting these rhythms through irregular sleep patterns or shift work can dysregulate metabolic hormones and promote weight gain. Consistent, high-quality sleep helps maintain healthy circadian rhythms, supporting optimal metabolic function.

Keep in mind: By prioritizing sleep hygiene practices and ensuring good, quality sleep, you can optimize the benefits of GLP-1 agonists such as semaglutide, which facilitate healthier eating habits, improved metabolic health, and, ultimately, more sustainable weight loss outcomes.

What can I do to get better sleep?

Start by maintaining a consistent sleep schedule, going to bed, and waking up at the same time every day, even on weekends. Create a relaxing bedtime routine to signal to your body that it's time to wind down, which may include activities like reading, gentle stretching, or taking a warm bath. 

Ensure your sleep environment is conducive to rest by keeping the room cool, dark, and quiet, and investing in a comfortable mattress and pillows. Limit exposure to screens and stimulating activities before bedtime, as blue light and mental stimulation can disrupt sleep. 

Finally, avoid caffeine, alcohol, and heavy meals close to bedtime, and aim to engage in regular physical activity earlier in the day to promote better sleep quality. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Today we are talking about peptide injections. We’ll cover some simple tips to remember before injecting your peptides to help avoid injuries and dosing errors. All this and more in less than 2 minutes. 

Tips to remember before injecting your peptides:

• Wash your hands with soap and water before handling your peptides and use an alcohol wipe to clean your injection site and rubber stopper on the top of the peptide vial. This will help prevent skin infections and bacteria from entering into the peptide vial. Allow the alcohol to completely dry on your skin before injecting your peptides. Otherwise, it can sting.
• Some peptides need to be refrigerated. While they can be injected cold, that can add to the discomfort of the injection. You can always draw up your peptide dose and set the syringe on the counter for 15-20 minutes to let the peptide solution come to room temperature on its own. Never warm your peptides in a microwave or oven.
• Another way to help with injection discomfort is to use ice to numb your skin before your injection. 
• If you are dealing with injection anxiety try counting down out loud. Three, two, one, now and then inject! You can also try playing your favorite music in the background.
• You can also try to have a peptide injection support person with you or on the phone during your injection. Sometimes having a friend or loved one near you eases anxiety. 
• You can always ask your provider if you can give your first injection in their office or over the phone with a nurse. This way you can ask questions and a nurse can walk you through the peptide injection to ease your worries. 
• Don’t recap the needle: It’s easy to poke yourself if you try to do this. After injecting, immediately throw away your used syringe into the sharps container. 
• Avoid injecting into scars, red or inflamed areas, or moles. This can cause further irritation to these skin areas.
• Bleeding may occur after giving a peptide injection. You can use a small cotton ball or a piece of gauze along with light pressure to stop the bleeding. If your bleeding won’t stop or you’re soaking through a cotton ball, call your healthcare provider.
• Mistakes can happen, especially if you’re new to giving yourself injections. Call your healthcare provider or clinical pharmacist as soon as possible, and they can tell you what steps to take next if you have questions.

You can find more information on injection techniques at pepties.com.  That’s peptides without the D. Where we are tying all the peptide therapy information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. We’ll see you next time on The Peptide Podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

People have increasingly been turning to peptide therapies to help manage health conditions alongside conventional medical care. And over the past year, we've talked about many of these peptides and how people have used them to support the body's own healing mechanisms, treat pain, improve function, find relief from certain symptoms, and improve quality of life.

But we haven't talked in depth about the importance of hydration. Drinking enough water each day is important for many reasons. Water helps keep our joints lubricated, delivers nutrients to our cells, keeps our organs working properly, and prevents infections. It also helps regulate our temperature, prevents constipation, and removes harmful waste through pee, sweat, and poop. Hydration also helps boost energy levels and helps with mood and memory. 

How much water should I drink?

The general rule is to take your total body weight in pounds and divide the number in half. This is about how many ounces of water you should drink each day. For example, a person who weighs 250 lbs should drink about 125 ounces or 3.6 liters of water daily. This is about six 20-ounce bottles of water daily.

Most people's everyday eating and drinking habits will help them meet their body's daily water needs. Simply put, if you drink fluids when you're thirsty and eat food when you're hungry, you're probably getting enough water each day.

All beverages, including tea, coffee, milk, soda, and juice, have water. But it's best to choose water or low-calorie or calorie-free drinks for hydration. High-calorie beverages like regular soda and juice can lead to weight gain and inflammation, increasing your risk for type 2 diabetes and heart disease.

Foods like cucumber, iceberg lettuce, watermelon, cantaloupe, strawberries, and zucchini have more than 90% water. 

How do I avoid dehydration?

It's important to remember that some people may need to drink more water than others. For example, people in hotter, dry climates lose more water through sweat and may need to drink more water to replace the fluids they lose.  

Also, if you're physically active (e.g., physically demanding job, exercising), you should increase your water intake to stay hydrated. This is especially important if you're working out or moving around outside in hot weather.

And some people with certain infections or medical conditions (e.g., IBS, Crohn's disease, ulcerative colitis, pregnancy) that cause diarrhea or vomiting may also need to drink more water. 

It's also recommended to increase your water intake during menopause and breastfeeding to stay hydrated. Breastfeeding can cause fluid loss through breast milk. And during menopause, the body may not be as good at self-regulating its hydration due to hormone changes.

Medications like Jardiance, Invokana, and Farxiga are used for type 2 diabetes, and diuretics used to treat conditions like high blood pressure and heart failure make you pee more. Because of this, people taking these medications need to drink more water to prevent dehydration. 

And people taking chemotherapy may also need to drink more water as it can cause a lot of vomiting and diarrhea, which could lead to dehydration.

How can I tell if I'm getting enough water?

An excellent way to tell if you're hydrated is to look at your pee. If the color of your pee is clear to pale yellow, you're getting enough water. On the other hand, if the color of your pee is dark yellow or brown, it may be a sign that you need to drink more water.  

Other signs that you may need to drink more water would be that you're peeing less or your pee smells different or bad. You could also have a dry mouth or lips or dry skin. Some people also have headaches, dizziness, and muscle cramping. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

GLP-1 agonists like semaglutide exert anti-inflammatory effects through many mechanisms. This has significant implications for health, particularly in conditions characterized by chronic inflammation such as obesity, diabetes, and neurodegenerative diseases. In this podcast, we’ll talk about how GLP-1 agonists produce their anti-inflammatory effects and the potential benefits associated with these actions.

How do GLP-1 Agonists Fight Inflammation?

Modulation of Immune Responses: GLP-1 plays a crucial role in controlling the activity of immune cells involved in inflammation. It can dampen the response of immune cells called macrophages, which are key players in the inflammatory process. By reducing the production of pro-inflammatory molecules and promoting the release of anti-inflammatory substances, GLP-1 helps restore balance to the immune system.

Inhibition of Inflammatory Pathways: GLP-1 exerts its anti-inflammatory effects by interfering with various signaling pathways that drive inflammation. For example, it can block the activation of nuclear factor-kappa B (NF-κB), a central regulator of inflammation that triggers the expression of pro-inflammatory genes. By inhibiting NF-κB and other inflammatory pathways, GLP-1 helps suppress the production of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β).

Reduction of Oxidative Stress: Oxidative stress, caused by an imbalance between free radicals and antioxidants in the body, contributes to inflammation and tissue damage. GLP-1 helps mitigate oxidative stress by enhancing antioxidant defenses and scavenging free radicals. By reducing oxidative damage, GLP-1 helps alleviate inflammation and protect cells from harm.

What are the potential benefits of GLP-1’s anti-inflammatory effects?

Improved Metabolic Health: Chronic inflammation is closely linked to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes. By combating inflammation, GLP-1 may improve metabolic health and help control blood sugar levels in individuals with diabetes. This can reduce the risk of complications associated with these conditions, such as cardiovascular disease and kidney damage.

Protection Against Cardiovascular Disease: Inflammation plays a significant role in the development of cardiovascular diseases such as atherosclerosis, heart attack, and stroke. GLP-1's anti-inflammatory effects help protect blood vessels and the heart from inflammation-induced damage, reducing the risk of cardiovascular events and improving overall heart health.

Potential for Neuroprotection: Inflammation in the brain is implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. GLP-1's ability to reduce neuroinflammation may have neuroprotective effects, preserving cognitive function and slowing the progression of these diseases.

Alleviation of Autoimmune Conditions: Autoimmune diseases, where the immune system mistakenly attacks healthy tissues, are characterized by chronic inflammation. GLP-1's anti-inflammatory properties may help alleviate symptoms and reduce disease activity in conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Peptide therapies, known for their diverse range of medical applications, are often administered through injections rather than oral pills or liquids. This stems from several important factors that influence the effectiveness and reliability of these treatments and patients' specific needs and preferences.

Today, we'll talk about the difference between oral and injectable peptide therapies and when to use them.

Peptide Structure and Digestive Process

To understand why one would use an injectable peptide therapy over an oral peptide therapy, we must first go over the digestive process and how pills work. 

Complexity of Peptides: As a reminder, peptides are made of linked amino acids, forming chains that vary in length and structure. When administered orally, peptides face challenges in surviving the harsh environment of the digestive system.

How do oral pills work?

When you swallow a pill, it goes to your stomach and intestines. It's then broken down by your digestive system and enters your bloodstream. 

When you swallow an oral peptide, it undergoes the "first pass effect ."This is when the body breaks down (metabolizes) a medication before it starts working. This typically happens in the liver but can also occur in the digestive system. When the oral peptide is broken down, its original concentration (amount) is decreased. Because of this, only some of the peptides in pill form enter your bloodstream.

Peptides given via injection avoid the first pass and enter the bloodstream directly. When this happens, a higher concentration of the intact peptide reaches the bloodstream and is more predictable and potent.

Digestive Enzymes: Digestive enzymes break down food to absorb the nutrients our bodies need. The three main digestive enzymes break down fats, carbohydrates, and proteins. 

Proteases in the stomach and intestines break down proteins, including peptides, into their constituent amino acids. Because of this, oral peptides are broken down and rendered ineffective before they reach the bloodstream.

Peptides administered through injections are more stable in their original form since they are not exposed to the digestive enzymes that can break them down.

Dosage Control: Injectable peptide therapies offer better dosage control than oral administration. Injections allow healthcare providers to administer the required dosage precisely, ensuring consistent and controlled therapy. This is extremely important for therapies requiring individualized dosing or specific amounts for optimal effectiveness.

Advancements in Oral Delivery: Despite the current preference for injectable peptide therapies, ongoing research focuses on developing innovative methods for effective oral peptide delivery. Encapsulation technologies, protective coatings, and specialized formulations aim to overcome the challenges of oral administration, potentially improving bioavailability and efficacy.

Keep in mind: People dealing with chronic issues like gastrointestinal (GI) problems or those seeking long-term maintenance and support for overall health might prefer the oral form of specific peptide therapies. It is more convenient and non-invasive than injections. Still, it may be more cost-effective for prolonged use in some instances. 

A great example of this is BPC 157. It's stable in human gastric juice for 24 hours. People taking it for gut health may prefer to take it orally. And those suffering from acute injury (muscle, tendon, or ligament injury) may want to use the injectable form when quicker healing and recovery is desired. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. It has vitamins, minerals, a diverse range of whole-food sourced ingredients, and probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It's vegan, paleo, and keto-friendly.

Today we are talking about aging and growth hormone. To get a better understanding of how peptide therapy works, we need to go over the aging process. All this and more in less than 2 minutes. 

What is growth hormone?

Growth hormone is a protein produced by the pituitary gland in the brain. The primary job of growth hormone in childhood is to stimulate bone and tissue growth. But it’s also very important in adults. 

Growth hormone helps regulate metabolism - in simple terms, it turns our food into energy or waste. It also helps to break down fat and helps with our bone strength, heart muscle function, and the amount of good and bad cholesterol we have in our bodies. All of this is super important because it reduces the risk of conditions like high cholesterol and osteoporosis (a condition in which our bones lose their strength). 

Through the aging process, growth hormone secretion decreases.  It’s common for aging people to experience a decline in strength and energy as well as other age-related changes like increased body fat, decreased lean muscle mass, or loss of skin elasticity… similar to those symptoms found in younger adults with growth hormone deficiency.

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It’s important to know that taking man-made (or synthetic) growth hormone, for long periods of time has potential side effects. Some people experience what’s called tachyphylaxis (decrease in response to a drug). While others experience reduced natural production of growth hormones. Other side effects may include swelling in the arms and legs OR joint and muscle pain.  

So how do we replace our growth hormone when our levels are decreasing? This is where peptides come in. Peptides work to stimulate your pituitary gland to release its own natural growth hormone, allowing you to avoid the potential side effects of the questionable use of man-made (synthetic) growth hormone. These peptides are known as growth hormone-releasing hormones (GHRHs) and growth hormone-releasing peptides (GHRPs).

The possibilities are endless! And we are just getting started. Join me next week where I’ll discuss GHRHs and GHRPs in great detail. You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media and subscribe to our podcast. Have a happy, healthy week!

Today we are talking about Selank and its potential benefits. All this and more in less than 2 minutes. 

What is Selank?

Selank is a lab-made peptide that was made by combining the naturally occurring peptide tuftsin with another sequence to make it more stable. Tuftsin makes up a large part of the natural antibody IgG. This antibody in our blood helps prevent infections. 

What are the BENEFITS? 

You may hear Selank referred to as the “anti-anxiety” peptide or a “nootropic.” In clinical trials, it has been shown to provide an anti-anxiety effect. It does this by affecting GABA. GABA is an inhibitory neurotransmitter. It slows down your brain by blocking signals in your central nervous system. It produces a calming effect and can reduce stress, improve sleep, and relieve anxiety. Selank works by enhancing the effect of GABA, thus reducing anxiety.

While most traditional anxiety prescription medications can cause bothersome side effects, clinical studies have shown that Selank doesn’t. You should not experience side effects like drowsiness, dependence, or withdrawal symptoms. 

In addition to its anti-anxiety benefits, Selank stabilizes blood enkephalins. Enkephalins are natural peptides found in the brain that help with stress. 

Its nootropic actions improve cognitive function, attention, memory, and motivation. Selank increases the amount of brain-derived neurotrophic factor (BDNF), an important brain growth compound in the hippocampus that helps with learning and memory.

Other studies have shown Selank to increase levels of IL-6, an inflammatory protein in the body that helps fight off infections. It’s also shown to decrease blood sugar and prevention of weight gain. This could be very helpful for those with metabolic syndrome. 

How do I take Selank?

Selank is given as an intranasal (into the nose) spray daily. You should not use more than you’re prescribed dose. Studies suggest doses above the maximum amount can reduce your response to Selank.

Possible side effects include headaches. Also, since it’s a nasal spray, you may experience a stinging or burning sensation in your nose or an unpleasant taste in your mouth. As always, you should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com. That’s peptides without the D. Where we are tying all the peptide therapy information together in one easy place.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we’ve got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you’ll need. This may include syringes, needles, alcohol pads, and a sharps container.

We’re huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Today, we’re talking about a fascinating topic that has been generating buzz in both the peptide and medical and wellness communities: microdosing GLP-1 agonists for overall health. 

In this episode, we'll explore how this emerging practice could impact metabolic health, weight management, and even longevity. Let’s break down what we know and what it could mean for you. 

What Are GLP-1 Agonists? 

Before we get into the idea of microdosing, let’s first understand what GLP-1 agonists are. GLP-1 stands for glucagon-like peptide-1. It’s a peptide hormone that plays a major role in regulating blood sugar levels and appetite. GLP-1 is found in many different areas of the body including the intestine, pancreas, and central nervous system. It’s also found in the hypothalamus.

GLP-1 agonists, like semaglutide (brand names Ozempic and Wegovy), are peptides that mimic this natural hormone. They're typically used for managing type 2 diabetes and, more recently, for weight loss. These peptides work by enhancing insulin secretion when glucose levels are elevated, slowing down gastric emptying, and reducing appetite. They also help lower blood pressure and stabilize blood sugar and cholesterol levels. Most recently they’ve been approved for improving cardiovascular health. 

What is Microdosing? 

Microdosing, in the context of GLP-1 agonists, refers to taking very small, sub-therapeutic doses of the peptide, typically much lower than those used in the treatment of diabetes or obesity. These smaller doses could potentially have a subtle impact on your metabolic heath, appetite, and overall well-being without causing the more intense side effects seen at higher doses. 

Why Microdose GLP-1 Agonists? 

I want to highlight several potential benefits of microdosing GLP-1 agonists for overall health, even for people who aren’t dealing with obesity or type 2 diabetes.

Improved Blood Sugar Regulation: GLP-1 agonists are known to help regulate blood sugar levels by enhancing insulin sensitivity. Microdosing could help prevent insulin resistance, a condition that often leads to chronic diseases like type 2 diabetes. Even if you’re not diabetic, stabilizing blood sugar can help improve energy levels, reduce cravings, and support better metabolic health.

Weight Management and Improved Satiety: One of the most well-known effects of GLP-1 agonists at higher doses is weight loss. Microdosing might help with weight management by subtly decreasing appetite and promoting more stable blood sugar levels, which could reduce those energy crashes and sugar cravings that often lead to overeating. 

For some people, microdosing could provide a gentle nudge toward more balanced eating habits and may help individuals manage emotional eating triggered by stress or fluctuating hunger signals.

Potential Longevity Benefits: The positive effects on insulin sensitivity, blood sugar, and body composition aren’t just about feeling good in the moment. There is also a potential long-term benefit of microdosing GLP-1 agonists, especially when it comes to longevity. Since insulin resistance and poor metabolic health are linked to aging, chronic disease, and even shorter life expectancy, using these peptides in low doses could theoretically help slow down some of these age-related processes. 

Reduced Inflammation: Chronic low-grade inflammation is a key contributor to many health issues, from cardiovascular disease to autoimmune conditions. Some studies have suggested that GLP-1 agonists may have anti-inflammatory effects, which could contribute to overall better health. Microdosing may help reduce systemic inflammation without the significant side effects that come with higher doses. 

When it comes to microdosing GLP-1 agonists, it’s important to start slow and work with a healthcare professional to tailor the dosing to your unique needs and goals (a more individualized approach).  But it’s important to keep in mind that while microdosing GLP-1 agonists is generally considered safe, there can be side effects, such as nausea or digestive discomfort, especially if the dose is not carefully monitored. That's why it's essential to start with a very low dose and gradually increase it under the guidance of a healthcare provider. 

What Does Microdosing GLP-1 Look Like in Practice? 

The specific dosing will depend on the individual, but in general, a "microdose" of semaglutide would be much lower than the typical prescribed dose for managing diabetes or obesity. For example, the typical starting dose for weight loss with semaglutide is 0.25 mg per week whereas a microdose might involve starting at a fraction of that amount. 

An example of a microdosing schedule might look like:

• Week 1-4: 0.025 mg to 0.05 mg once a week (roughly 1/10th to 1/5th of the initial standard dose).

• Week 5-8: 0.05 mg to 0.1 mg once a week.

• Beyond Week 8: Gradual increase (if tolerated) to higher doses, but still at a much smaller increment compared to the full therapeutic dose.

The most important part of microdosing is closely monitoring how your body responds, adjusting the dose based on any side effects, and ensuring that you’re still supporting your health with good nutrition, exercise, and other lifestyle practices. 

Is Microdosing GLP-1 Right for You? 

As with any new health trend, it's important to remember that not every approach works for everyone. While the concept of microdosing GLP-1 agonists is promising, especially for those looking to improve their metabolic health, it should be approached with care and ideally under the supervision of a healthcare professional. 

If you're interested in experimenting with microdosing GLP-1 agonists, speak with your healthcare provider to see if it could be a beneficial strategy for your health goals. And always remember, the best way to manage your health is through a holistic approach that includes proper nutrition, regular exercise, stress management, and sleep. 

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

In the journey of weight loss, everyone eventually reaches a plateau, even when using newer GLP-1 receptor agonists like semaglutide (Wegovy) and tirzepatide (Zepbound). This phase is where the body finds a new set point and weight. During this plateau, some individuals may experience a gradual increase in appetite or “food noise”, while others can maintain their current state. Other metabolic markers like blood pressure and A1c, stabilize or only fluctuate slightly.

It’s important to remember that everyone will plateau. And it’s impossible to predict the specific timing, percentage of weight loss, or speed at which a person will reach their plateau when they start a GLP-1 agonist. 

What do the studies say? Clinical studies show that this plateau typically occurs a little over a year (about 60 weeks) into treatment with semaglutide. However, a common myth is that if you hit a weight loss plateau while using these medications, it means they are no longer working. And this myth can lead to unnecessary frustration and discontinuation of treatment. 

I like to remind patients that reaching a new set point is a common phenomenon in many health conditions. For example, a patient on blood pressure medication will not become hypotensive indefinitely, and similarly, blood glucose levels will not decrease indefinitely with diabetes medications. So it should be no surprise that you won’t lose weight indefinitely while taking a GLP-1 agonist. This evolutionary mechanism is essential for protecting the body against extremes. 

In this podcast, we’ll talk about strategies to move past the weight loss plateau if you haven’t yet met your weight loss goal. 

Understanding Weight Loss Plateaus

A weight loss plateau occurs when you stop losing weight despite maintaining your diet and exercise routine. This is a common experience for many people on a weight loss journey, regardless of whether they are using GLP-1 agonists or not. Several factors can contribute to a plateau:

• Metabolic Adaptation: As you lose weight, your metabolism slows down because your body requires fewer calories to maintain a smaller body size.

• Reduced Caloric Deficit: You may lose weight quickly initially, but as you progress, the caloric deficit narrows, slowing down weight loss.

• Water Retention and Muscle Gain: Changes in water balance and muscle mass can temporarily affect weight measurements.

• Behavioral Factors: Over time, adherence to diet and exercise routines can wane, impacting progress.

Why GLP-1 Agonists Are Still Effective During a Plateau

GLP-1 agonists continue to work by regulating appetite, improving insulin sensitivity, and promoting satiety. These mechanisms support long-term weight management and metabolic health, even if weight loss temporarily stalls. Plateaus do not negate these ongoing health benefits.

Strategies to Overcome a Weight Loss Plateau

1. Reevaluate Your Caloric Intake: As you lose weight, your caloric needs decrease. Adjust your daily caloric intake to reflect your new body weight and activity level. Consider consulting a dietitian to ensure your nutrition plan is optimal.

2. Increase Physical Activity: Incorporate more physical activity into your routine. Adding strength training can help build muscle, which can boost metabolism. When we lose weight, we lose both muscle and fat. Physical activity is crucial during a weight loss journey because it helps preserve lean muscle mass and boosts metabolism, ensuring that the weight loss is primarily fat rather than muscle.

3. Monitor Macronutrient Balance: Ensure you are consuming the right balance of proteins, fats, and carbohydrates. Protein, in particular, can help preserve muscle mass and promote satiety.

4. Stay Hydrated: Proper hydration is essential for overall health and can aid in weight loss. Sometimes, perceived plateaus are due to water retention, which can be mitigated by drinking adequate water.

5. Manage Stress and Sleep: Stress and poor sleep can negatively impact weight loss. Incorporate stress-reducing activities such as mindfulness, yoga, or hobbies you enjoy, and aim for 7-9 hours of quality sleep per night.

6. Review Medication Adherence: Ensure you are taking your GLP-1 agonist as prescribed. Consistency is key to reaping the full benefits of the medication. Both semaglutide and tirzepatide should be taken once weekly. 

7. Be Patient and Persistent: Understand that plateaus are a normal part of the journey. Patience and persistence are crucial. Celebrate non-scale victories, such as improved energy levels, better blood sugar and blood pressure control, and enhanced overall health.

8. Increase Dose: Increasing the dose of a GLP-1 agonist may be necessary for some individuals, but it isn't always the solution. Some individuals may need dosage adjustments more frequently than every four weeks for optimal results. The goal is to find the optimal dose at which you continue to lose weight gradually, experience appetite suppression, and have minimal to no side effects.

For those taking GLP-1 agonists for weight loss without making any changes to their nutrition or physical activity levels, it's important to understand that maximizing the medication's benefits and achieving sustainable results largely depend on adopting a balanced diet and regular exercise routine.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Peptide therapies have gained significant attention in various medical fields, including sports medicine, anti-aging treatments, and weight loss. However, like many injectable medications, peptide therapies can sometimes lead to injection site reactions. These reactions, which may include bruising, pain, redness, and itching, can be bothersome but are typically manageable with proper care and attention. If you’ve had an injection site reaction, you may be wondering if it’s an allergy or something you can manage at home.

In this podcast, we'll talk about what you should know about injection site reactions and how to take care of them.

Understanding Injection Site Reactions

Before we discuss management strategies, it's important to understand how injection site reactions can occur. To put it simply, they happen if something in the injection irritates your skin or causes your immune system to overreact. When the reaction is caused by an irritant, it tends to happen quickly (within a couple of hours) and last a few days. On the other hand, reactions that kick your immune system into high gear can develop in a few hours or a few days and last longer.

Keep in mind that injection site reactions typically get worse over the first 24 hours but things should get better after that.

Common types of injection site reactions

The common types of injection site reactions that may occur with peptide therapies:

Bruising: Bruising at the injection site occurs when small blood vessels are damaged during the injection process, leading to the leakage of blood into the surrounding tissue.

Pain: Injection site pain can vary in intensity and duration. It may result from tissue trauma, nerve irritation, or the properties of the injected peptide itself.

Redness, warmth, or swelling: Redness or erythema at the injection site is often a sign of inflammation caused by the body's immune response to the injection.

Itching: Itching or pruritus at the injection site can occur due to histamine release or irritation of the skin.

How to Manage Injection Site Reactions

Some practical tips and strategies to help manage injection site reactions associated with peptide therapies:

Practice Good Hygiene: Before and after administering the injection, thoroughly clean the injection site with an alcohol swab to reduce the risk of infection. Additionally, wash your hands with soap and water to maintain proper hygiene throughout the injection process.

Rotate Injection Sites: To minimize the risk of tissue damage and reduce the likelihood of developing injection site reactions, it's essential to rotate injection sites regularly. Alternate between different areas of the body, such as the abdomen, thighs, and buttocks, following the recommended injection guidelines provided by your healthcare provider.

Apply Cold Compress: Immediately after the injection, apply a cold compress for 5 to 10 minutes or ice pack to the injection site to reduce redness, warmth, swelling, bruising, and pain. Cold therapy helps constrict blood vessels and minimize blood leakage into the surrounding tissue.

Apply Warm Compress: Warm compresses can be soothing if your muscle hurts after an intramuscular injection. Just remember to be careful and not burn your skin. You can apply a warm compress for 15 to 20 minutes.

Use Proper Injection Technique: Ensure that you are using the correct injection technique as instructed by your healthcare provider. This includes proper needle insertion angle, injection depth, and injection speed. Avoid injecting too quickly or forcefully, as this can increase tissue trauma and discomfort.

Get feedback on your injection technique: The way you inject your medication could be the cause of your injection site reaction. Ask your healthcare provider to watch you give yourself an injection so they can give you feedback and advice on where to properly inject.

Over-the-counter pain relievers: Over-the-counter pain relievers containing ingredients such as ibuprofen or acetaminophen can help alleviate injection site pain and discomfort.

Anti-itch medications: If you’re having a lot of itching at the injection site, you can try an OTC antihistamine like diphenhydramine.

Avoid irritated skin: Avoid any sites where your skin is already irritated (e.g., rash,cut, scaling, plaques). Irritated skin is already inflamed and more likely to have a reaction.

Avoid Scratching: While itching at the injection site can be uncomfortable, avoid scratching or rubbing the area, as this can exacerbate irritation and increase the risk of infection. Instead, gently pat or massage the area to help alleviate the itching sensation. 

What are some more serious symptoms that I need to be aware of?

More serious symptoms can be a sign that you’re experiencing something else. If you notice hives, fever, excessive fatigue, blistering at the injection site, or severe swelling, talk to a healthcare provider.  These symptoms could be due to an allergic reaction or skin infection.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Today we’re exploring a fundamental topic that plays a crucial role in nearly every biological process — amino acids. Whether you're a fitness enthusiast, a foodie, or just someone who wants to understand how your body works, this episode is for you. 

We’ll talk about what amino acids are, why they're important, the different types, and how you can get them through your diet. So, let's jump right in. 

What Are Amino Acids? 

Amino acids are the building blocks that make up proteins, just like how bricks make up a house. When amino acids are connected together in a short chain, they form something called a peptide. When they're connected in a longer chain, they form a protein.

Here’s how they differ:

1. Peptides: These are smaller chains of amino acids. They can have just a few amino acids connected together, usually fewer than 50. Think of them like small groups of people holding hands, where each person is an amino acid. Peptides are involved in many processes in the body, like helping to build muscles, fight infections, and carry signals between cells.

2. Proteins: These are much longer chains of amino acids, usually with 50 or more amino acids connected together. Proteins can be very big and complex. They fold into specific shapes that allow them to do important jobs in the body, like carrying oxygen in the blood (hemoglobin), making up muscles, or helping break down food during digestion.

So, the main difference is size and complexity: Peptides are short chains of amino acids, while proteins are long, often much more complicated chains that do a lot of work in the body.

Now, you might be thinking, “Why are they so important?” Well, without amino acids, we wouldn’t be able to make peptides or proteins. And without peptides and proteins, our cells wouldn’t be able to function properly. They’re essential for tissue growth, enzyme production, and even maintaining healthy skin and hair. 

What Are The Types of Amino Acids? 

There are 20 different amino acids that your body uses to make proteins. These are split into three categories: 

• Essential Amino Acids

• Non-Essential Amino Acids

• Conditionally Essential Amino Acids

Let’s take a closer look at each of these. 

Essential Amino Acids

First up, we have essential amino acids. These are the amino acids that your body cannot produce on its own. This means we have to get them from our diet. 

There are 9 essential amino acids, and they include well-known ones like leucine, histidine, and tryptophan.  There’s also valine, isoleucine, lysine, methionine, phenylalanine, and threonine.

• Histidine: Supports the production of histamine (a neurotransmitter), helps with immune system function, and plays a role in sleep, digestion, and sexual health.

• Leucine: Aids in protein and growth hormone production, helps repair muscle tissue, supports wound healing, and contributes to blood sugar regulation.

• Isoleucine: Promotes immune function, muscle metabolism, hemoglobin production, and helps regulate energy.

• Lysine: Involved in hormone production, calcium metabolism, and supports immune system function.

• Methionine: Important for tissue growth and regeneration, detoxification, metabolism, and nutrient absorption.

• Phenylalanine: A precursor to neurotransmitters like dopamine, epinephrine, and norepinephrine, and helps synthesize other amino acids.

• Threonine: Essential for the production of elastin and collagen, helps form blood clots, supports fat metabolism, and boosts immunity.

• Tryptophan: Maintains nitrogen balance and is crucial for serotonin production.

• Valine: Supports tissue regeneration, muscle growth, and energy production.

Non-Essential Amino Acids

Next, there are the non-essential amino acids. These are the 11 amino acids that our bodies can make on their own, even if we don't get them from food. Examples include alanine and glutamine. You may have also heard of cysteine and tyrosine. 

Conditional Amino Acids:

Finally, we have conditional amino acids. They’re also called conditionally essential amino acids (CEAAs). There are 3 amino acids that are normally non-essential, but under certain conditions — like illness, stress, or injury — they become essential. An example is arginine, which your body usually makes, but during times of stress, it may need to come from your diet. Other examples include histidine and glycine.

What Are Branched Chain Amino Acids?

Branched-chain amino acids (BCAAs) are three essential amino acids—leucine, isoleucine, and valine—that the body uses for muscle recovery and athletic performance. You can find BCAAs in foods like dairy, meat, and beans, and they are also available as supplements.

The Benefits of Amino Acids 

Amino acids do so much more than help you build muscle — although that’s a pretty big perk. Let’s take a look at some of their other benefits. 

First, amino acids support muscle recovery. If you’re into working out or engaging in high-intensity sports, your muscles experience wear and tear. Amino acids like leucine, for instance, stimulate protein synthesis, which is crucial for muscle repair. 

But it’s not just athletes who need them. Amino acids also help with immune system support. Certain amino acids like glutamine fuel immune cells, helping your body fight off infections and illnesses. 

They’re also important for brain health. Amino acids such as tryptophan are precursors to neurotransmitters like serotonin, which help regulate mood, sleep, and appetite. 

And let’s not forget energy production. Some amino acids can even be used for energy if your body needs it, especially during long endurance activities or times of calorie restriction.

Conditional amino acids are also needed for growing children, pregnant women, and lactating women. Studies have shown that people who received conditionally essential amino acids after surgery for bone fractures experienced fewer medical complications during recovery and had a lower risk of death.

Researchers have found that cancer patients who receive branched-chain amino acids are less likely to experience complications like infections and fluid buildup in the abdomen. 

Additionally, controlled clinical trials suggest that older adults recovering from knee replacement surgery can reduce muscle loss by taking essential amino acid supplements.

What Is The Best Way to Get Essential Amino Acids?

So, how do we make sure we’re getting enough essential amino acids? The good news is that many foods provide these.

For those who eat animal products, foods like chicken, beef, fish, eggs, and dairy are excellent sources of all nine essential amino acids. These are considered complete proteins because they contain all the essential amino acids your body needs. 

For vegetarians and vegans, the challenge is making sure you’re getting a full range of amino acids. Fortunately, there are many plant-based options, too. Foods like quinoa, soy products (tofu, tempeh), lentils, beans, and nuts are great plant-based protein sources. While some plant proteins are incomplete, combining different foods — like beans and rice — can provide all the essential amino acids. Complete protein options for vegetarians include chia and hemps seeds, buckwheat, soy products, spirulina, and edamame

If you're actively trying to build muscle or recover from a workout, supplements containing essential amino acids or branched-chain amino acids (BCAAs) might be helpful. 

Whether you’re eating a steak, a quinoa bowl, or taking a post-workout supplement, getting a variety of amino acids is key to keeping your body healthy.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Today, we’re diving into an exciting peptide therapy called tesamorelin. You might have heard of it if you're interested in anti-aging treatments. 

In this episode, we’ll break down exactly what tesamorelin is, how it works in the body, and the potential benefits it can offer. Plus, we’ll talk about the possible side effects and risks associated with the therapy, and how it compares to another popular peptide we discussed last week, sermorelin. 

What is Tesamorelin?

Tesamorelin is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) analog. In simple terms, it stimulates the body’s natural production of growth hormone (GH) by targeting the pituitary gland, which is responsible for releasing growth hormone. 

Unlike direct growth hormone replacement therapy, where you inject synthetic growth hormone into your body, tesamorelin works by prompting your body to produce its own growth hormone naturally. This is often considered a more natural approach to restoring optimal hormone levels.

Originally, tesamorelin was approved by the FDA to treat lipodystrophy (abnormal fat distribution) in HIV patients who were experiencing excess abdominal fat. However, its use has since expanded in the realm of anti-aging and fat loss due to its ability to promote fat metabolism, muscle development, and overall vitality.

How Does Tesamorelin Work?

In essence, tesamorelin taps into your body’s natural ability to produce growth hormone, rather than injecting it directly. This is why it’s often considered a safer, less invasive alternative to traditional growth hormone therapy. It’s typically given once daily via subcutaneous injections (just under the skin). Depending on the health condition being treated, some individuals may need to dose less frequently.

What’s the Difference Between Tesamorelin and Sermorelin?

While both tesamorelin and sermorelin are peptides that stimulate the release of growth hormone, they differ in their structure and the specific ways they interact with the body.

• Tesamorelin is a modified version of GHRH that specifically targets the release of growth hormone from the pituitary gland. It’s particularly effective in reducing abdominal fat (especially visceral fat) and improving body composition, which makes it popular for individuals seeking fat loss and anti-aging benefits.

• Sermorelin, on the other hand, is a shorter form of GHRH and has a more general effect on growth hormone secretion. While it also stimulates the pituitary to release growth hormone, it is often used in younger individuals or those seeking overall growth hormone balance and anti-aging benefits rather than specifically targeting fat loss.

Potential Benefits of Tesamorelin Therapy

1. Fat Loss and Body Composition:
   One of the most well-known benefits of tesamorelin is its ability to reduce abdominal fat and improve overall body composition. It is especially effective at targeting visceral fat, the fat stored around internal organs. This can be beneficial for those looking to lose stubborn belly fat, which is linked to several health issues like heart disease, diabetes, high blood pressure, and fatty liver disease.

2. Improved Muscle Mass:
   Since growth hormone plays a key role in muscle development, tesamorelin can help increase lean muscle mass and improve muscle tone. It’s especially helpful for older adults or people recovering from injuries who want to retain or regain muscle strength.

3. Increased Energy Levels:
   Higher levels of growth hormone can result in improved energy, vitality, and endurance. Many patients report feeling more energized throughout the day, which can improve quality of life and overall activity levels.

4. Better Skin and Hair Health:
   Tesamorelin’s effects on collagen production can contribute to improved skin tone, elasticity, and texture. It may also benefit hair health, making it a popular option for individuals seeking anti-aging benefits beyond just fat loss and muscle gain.

5. Improved Metabolism:
   Tesamorelin may enhance the body's metabolism, aiding in better fat burning and more efficient use of nutrients, which can be beneficial for weight management.

6. Cognitive Function:
   Some studies suggest that tesamorelin may have cognitive benefits, including improved memory and mental clarity, likely due to the overall boost in growth hormone levels.

Potential Side Effects and Risks

As with any therapy, tesamorelin comes with potential side effects and risks. While side effects are generally mild and well-tolerated, they can include:

• Injection site reactions: Pain, redness, or swelling at the injection site.

• Headaches: Some people report mild to moderate headaches, especially when first starting the therapy.

• Joint pain or muscle aches: Increased growth hormone levels can sometimes lead to discomfort in muscles or joints.

• Fluid retention: Some individuals may notice mild swelling or bloating, particularly in the hands or feet.

Long-term use of growth hormone-stimulating therapies like tesamorelin may increase the risk of carpal tunnel syndrome, joint issues, or diabetes in predisposed individuals. 

Although rare, there is a concern that stimulating growth hormone production could accelerate the growth of existing cancers, so it’s important to have a thorough health evaluation before starting therapy.

As always, consulting with a healthcare provider before starting tesamorelin therapy is essential, especially if you have a history of cancer, pituitary gland disorders, or chronic health conditions.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Today we’re diving into an important topic for anyone considering or currently using MOTS-c peptide therapy. We’ll be discussing injection site reactions, a common side effect for many patients. 

Whether you're just starting treatment or have been using MOTS-c for a while, understanding what to expect and how to manage these reactions can make all the difference in your experience. So, stay tuned as we break it all down, from symptoms to solutions, right here on

When it comes to injectable treatments, an injection site reaction refers to any type of irritation or physical response at the spot where the needle enters the skin. For MOTS-c, these reactions can range from mild to moderate, and in rare cases, more severe. Typical reactions include redness, swelling, pain, itching, or a lump at the injection site.

First, let's break down the most common signs of injection site reactions for MOTS-c:

• Redness or Discoloration: This is one of the most commonly reported reactions, where the area around the injection site becomes visibly red or irritated.
  
  

• Swelling or Bumps: Another common issue, where a small, sometimes hard lump forms under the skin. This may be accompanied by mild swelling that can last a few hours or up to a day or two.
  
  

• Pain or Tenderness: Mild pain is often reported, which can feel like soreness or tenderness at the injection site, typically disappearing after a short while.
  
  

• Itching or Rash: Itching can occur shortly after the injection, and sometimes a rash may develop, which is usually mild.
  
  

Many MOTS-c users experience a temporary reaction that can be uncomfortable but is usually not severe.

The time it takes for the reaction to begin and resolve can vary. 

Most injection site reactions appear within a few minutes to a few hours after the injection. In the case of MOTS-c, users usually feel tenderness or notice redness and swelling shortly after the injection. It’s not uncommon for mild itching to follow within a few minutes as well.

For many people, the reaction will last anywhere from a few hours to two days. Redness and swelling usually start to subside within 12 to 24 hours. The lump or bump that forms under the skin may take a little longer to disappear, anywhere from 1 to 2 days.

While most reactions are short-lived and relatively mild, they can be bothersome to some. However, there are things you can do to help minimize discomfort and speed up recovery.

How to Manage Injection Site Reactions 

If you're experiencing an injection site reaction, don’t panic. There are a few strategies you can use to make the process more comfortable:

1. Ice Packs and Heat Pads: Right after the injection, applying a cold compress can help with swelling and pain. After a few hours, you can switch to a warm compress to help ease any lingering discomfort or swelling. Be sure to wrap the ice or heat pack in a cloth to avoid direct contact with your skin.

2. Massage: Gently massaging the area can sometimes help disperse the fluid build-up under the skin, especially if you’re dealing with a small lump. Just make sure to wait for a few hours after the injection before gently rubbing the area. This allows the initial inflammation and discomfort to settle down a bit before applying pressure to the site. When you do begin rubbing, use gentle, intermittent circular motions. Don’t massage continuously or too aggressively. Avoid applying too much pressure, as that can worsen the swelling or cause additional irritation.  A few short minutes should be enough to help.

3. Topical Creams: Some users find relief from topical hydrocortisone cream or anti-itch ointments for soothing the area if itching or irritation is a problem. Be cautious, though—apply sparingly to avoid causing further irritation.

4. Rotate Injection Sites: One of the best ways to prevent persistent reactions is by rotating injection sites. This helps to ensure that no one area of the skin becomes overly irritated or scarred. It also gives each site time to heal before being used again.

5. Proper Injection Technique: If you’re administering the injection yourself, make sure to follow all the instructions for proper technique. Using a clean needle and making sure the injection is done at the right angle can reduce the risk of complications and minimize irritation.

If you experience any signs of a possible allergic reaction, such as hives, a rash, swelling of the face, lips, or tongue, or symptoms of infection like pus, fever, or chills, it's important to contact your healthcare provider immediately. They may suggest an alternative treatment or provide guidance on how to manage the reaction safely.

Just remember, injection site reactions are a known side effect of MOTS-c therapy. The key is to be prepared and proactive. Understanding what to expect and knowing how to manage the discomfort can make your experience with MOTS-c much better.

 Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Today we are talking about Ipamorelin and its potential benefits. All this and more in less than 2 minutes. 

What is Ipamorelin?

Ipamorelin is a lab-made, primarily functioning as a growth hormone-releasing peptide (GHRP) or inducer. Ipamorelin works by mimicking the body’s natural release of growth hormone release. It does this by increasing the number of somatotrophs (or cells responsible for growth hormone release) and it suppresses somatostatin (a growth hormone inhibiting hormone). 

Ipamorelin is often used in combination with CJC 1295 because they work well together. This combination will promote the increase of growth hormone and is used for anti-aging purposes and in people with inflammatory conditions or those who have low IGF-1 levels.

So what are the benefits?

Like CJC 1295, Ipamorelin is useful to those looking to increase lean muscle mass and strength by stimulating the release of growth hormone. It also promotes muscle recovery from workouts and helps the growth of muscle tissues resulting in quicker recovery times.

Ipamorelin also leads to increased energy, improvements in sleep, and bone density.

BUT DOES IT WORK? 

Like we said last week…Peptide therapies are not miracles in a bottle. They don’t guarantee desired results. Like anything in life, you must also make lifestyle changes when it comes to certain desired outcomes. For example, a poor diet and lack of exercise can have a very negative impact on your health and cause weight gain, skin issues, joint pain, and can even lead to type 2 diabetes.

Peptide therapy in addition to healthy lifestyle choices can help you achieve your goals!

Possible side effects include redness or itching at the peptide injection site. You should tell your healthcare provider about any side effects you may experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together in one place. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love what you’ve heard on this podcast please share it with your friends and family on social media. We’ll see you next time. Have a happy, healthy week!

Today we're going to talk about fruit and some common myths about fruit sugars that have formed. 

Most myths happen when people misunderstand research or news stories. The truth is many different fruits make a great addition to your snacks and meals. But fructose, the sugar in fruit, is often considered unhealthy, and some people avoid eating fruit because of this.

I get asked about fruit sugar a lot. Of course, how much fruit sugar you consume is important for any nutrition plan, but also it's important for people taking semaglutide as it should be used with lifestyle changes, including a healthy diet and exercise, to help people lose weight.

But first, I think it's important to review the difference between simple and complex sugars. On a basic level, simple sugars are broken down quickly by the body. Complex sugars take a longer time to break down. 

The time it takes for sugar to move through your digestive system is important because it affects your blood sugar. Simple sugars increase your blood sugar more quickly, while complex sugars lead to a more steady increase in your blood sugar.

Because of this, it's recommended to eat mostly complex sugars and limit simple sugars. But, not all simple sugars increase blood sugar faster than complex sugars. For example, because fruit has fiber, your body will absorb it more slowly, causing your blood sugar to increase less than it would if you ate a piece of cake. 

What are some examples of simple sugars?

As we said, simple sugars include natural sugars like whole fruit, and processed sugars are added to foods like baked goods, cereals, and other ultra-processed foods (e.g., soda, candy, ice cream, and packaged snacks).

What are some examples of complex sugars?

Complex sugars are usually found in whole foods and unprocessed foods. This would include foods like quinoa, rice, sweet potato, fresh vegetables, beans, and lentils. 

How much fructose is okay to eat per day?

It's recommended to eat 2 cups of whole fruit per day. It's best to avoid packaged dried fruit and fruit juice. Dried fruit is typically higher in sugar, depending on how it's made and packaged. Fruit juice lacks fiber and also tends to have added sugars. 

There are also many health benefits from eating whole fruit. Keep in mind whole fruit is rich in vitamins and minerals. And fruits like wild blueberries, cranberries, blackberries, plums, raspberries, and strawberries have many beneficial antioxidants that may help delay aging. 

Studies also show that eating fruit lowers your risk of dementia, depression, Alzheimer's disease, heart disease, high blood pressure, and type 2 diabetes. This is likely due to the anti-inflammatory antioxidants found in fruit.

We've discussed gut health on this podcast in the context of BPC 157 and the importance of maintaining a healthy gut microbiome. And we learned that your gut microbiome plays many roles in your body, from digesting your food to breaking down toxins in your gut and protecting you from outside bacteria.

Many factors can influence your gut microbiome. Your genes, upbringing, and habits can all affect your gut microbiome. Because your gut microbiome is made up of living bacteria and organisms, it may change over time. One of the main influences on our gut microbiome is our diet. It's important to focus on eating diverse foods, particularly high-fiber foods like whole fruits and vegetables, to lower our risk of constipation and even colon cancer.

Which fruits are the lowest in sugar?

Raspberries (3 grams of sugar/ 1 cup), strawberries (5 grams of sugar/ 1 cup), watermelon (6 grams of sugar/ 1 cup), and blueberries (9 grams of sugar/ 1 cup) are among the top fruits with the lowest amount of sugar. 

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're continuing our mini-series on peptides and sexual wellness. Last week we talked about everything you need to know about PT-141 (bremelanotide). 

Today, we'll focus on Kisspeptin-10, what it is, how it works for sexual wellness and some of its other benefits.

What is Kisspeptin-10?

Kisspeptin-10 is a neuropeptide that’s involved in reproduction, sexual behavior, and sexual attraction. It helps increase activity in the brain associated with sexual attraction and arousal. 

Kisspeptin-10 also stimulates the hypothalamus to release gonadotropin-releasing hormone (GnRH), which in turn signals the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones play a role in the production of both testosterone and estradiol. 

This more physiological stimulation of LH and FSH may reduce the risk of overstimulation of the ovaries often associated with fertility injections. Because of this, Kisspeptin is currently being studied as an alternative to current fertility treatments.

Because Kisspeptin-10 increases both LH and FSH, it may benefit men undergoing testosterone replacement therapy (TRT) programs who have experienced a drop in their LH or FSH levels due to excessive amounts of exogenous testosterone.

How is Kisspeptin-10 dosed and given for sexual health?

Kisspeptin-10 is given as an injection under the skin (subcutaneously). You can give the injection with or without food into your abdomen, upper arm, or thigh. You should avoid injecting into the same spot every time. But you can inject into the same body area (e.g., abdomen) as long as you rotate your injection site. 

The dose of Kisspeptin-10 is 100 mcg in the evening. 

What are the potential side effects of Kisspeptin-10?

As with any injection, you may experience injection site reactions like pain, redness, itching, or bruising. But, no side effects have been reported in clinical studies to date.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

Today we are talking about Epitalon, what it’s for, and its potential benefits. All this and more in less than 2 minutes. 

What is Epitalon?

Epitalon, is a lab-made version of the polypeptide Epitalamin which is naturally made in the pineal gland in the brain. It’s known for its anti-aging properties, stress reduction, and disease prevention.

What are its benefits?

Epitalon helps slow down the aging process by increasing the natural production of telomerase, a natural enzyme that helps cells to keep multiplying and making telomeres. Telomeres are the protective parts of our DNA, found at the ends of our chromosomes that help keep our chromosomes organized. This, in turn, decreases cell death and extends cell lifespan. 

Epitalon also acts as an antioxidant that eliminates free radicals that are responsible for damaging and killing cells. Free radicals, simply put are unstable atoms that can damage cells, causing illness and aging. In turn, Epitalon plays an important role in helping to suppress cancerous tumor growths.

Epitalon also restores and normalizes melatonin levels in older people who have lost some pineal gland function due to aging. Melatonin is a hormone your brain makes in response to darkness. It helps with sleep and your sleep-wake cycles. This is useful to those looking for more restful sleep.

How do you use this?

Epitalon can be used as a starting therapy to help DNA repair or as an antioxidant. It can also be given as a stand-alone therapy twice a year for cell protection, improving cell resistance, and stopping cell death. Some healthcare providers dose Epitalon intermittently along with other scheduled peptide therapies. The peptide injection is intramuscular (injected into the muscle).

Possible side effects include redness, itching, or swelling at the injection site. You should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together for you in one place.

A class of medications known as GLP-1 receptor agonists has revolutionized the treatment of type 2 diabetes and obesity. These drugs mimic the action of glucagon-like peptide-1 (GLP-1), a hormone that stimulates insulin secretion and inhibits glucagon release, helping to regulate blood sugar levels and promote weight loss. In this podcast, we’ll talk about the differences among some of the most well-known GLP-1 receptor agonists for type 2 diabetes.

Ozempic (Semaglutide)

• Form: Injectable

• Dosing Frequency: Once weekly

• Uses: Primarily for type 2 diabetes (lower blood sugar and A1c); also approved for reducing the risk of major cardiovascular events like heart attack and stroke in adults with type 2 diabetes and known heart disease.

Keep in mind, Wegovy (semaglutide) is a higher-dose version that’s approved for weight loss. When you start taking Wegovy or Ozempic, you’ll begin with a low dosage. Your prescriber will increase your dosage every four weeks until you reach the target amount. However, the specific dosage you inject will differ depending on the medication. The maximum dose for Ozempic is 2mg weekly, while the target dose for Wegovy is 2.4mg weekly.

Rybelsus (Semaglutide)

• Form: Oral tablet

• Dosing Frequency: Once daily

• Uses: Lower blood sugar and A1c in people with type 2 diabetes.

Rybelsus shares the same active ingredient as the injectable medications Ozempic and Wegovy. Ozempic is also approved for Type 2 diabetes, while Wegovy is approved specifically for weight loss.

Rybelsus is available in three different strengths: 3 mg, 7 mg, and 14 mg. Similar to Ozempic, the dose is slowly increased every 4 weeks. 

Good to know: It's important to take Rybelsus first thing in the morning with 4 oz of water. After taking it, you should wait at least 30 minutes before eating, drinking, or taking other medications. Failing to do so may reduce its effectiveness.

Currently, Rybelsus is undergoing clinical trials to evaluate its effectiveness for weight loss. The trials involve higher doses than those approved for diabetes treatment. Results indicate that a 50 mg dose of oral semaglutide (Rybelsus) achieves weight loss comparable to Wegovy. 

Trulicity (Dulaglutide)

• Form: Injectable

• Dosing Frequency: Once weekly

• Uses: Type 2 diabetes; and like Ozempic, it’s also approved for reducing the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.

Like Ozempic and Rybelsus, you will start at a low dose to help reduce side effects. Your healthcare provider will then gradually increase the dose, balancing the management of side effects with the benefits of blood sugar control. The maximum dose for Trulicity is 4.5mg weekly.

Victoza (Liraglutide)

• Form: Injectable

• Dosing Frequency: Once daily

• Uses: Type 2 diabetes; also approved to reduce the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.

Victoza is one of three GLP-1 agonists approved for treating Type 2 diabetes in children aged 10 and older. The other options are Trulicity (dulaglutide) and Bydureon BCise (exenatide). More on this later. Ozempic, however, is only approved for use in adults.

Saxenda and Victoza are both injectable medications containing liraglutide, but they are approved for different uses. Saxenda is FDA-approved for chronic weight management in people 12 and older, while Victoza is approved for treating Type 2 diabetes in people 10 and older. Victoza also helps lower the risk of major adverse cardiovascular events in adults with diabetes and heart disease.

Both medications are injected once a day, starting with a low dose that is gradually increased over time. The target dose for Saxenda is 3 mg once daily, whereas the maximum dose for Victoza is 1.8 mg once daily.

Byetta (Exenatide)

• Form: Injectable

• Dosing Frequency: Twice daily

• Uses: Type 2 diabetes.

• Additional Benefits: It has a shorter duration of action than other GLP-1 agonists, which may be preferable for some patients.

Byetta, approved in 2005, was the first GLP-1 medication of its kind for diabetes. Its active ingredient, exenatide, is a synthetic version of a substance found in Gila monster saliva. 

The recommended starting dose for Byetta is 5 mcg twice daily, administered within 60 minutes before your morning and evening meals. After one month, your healthcare provider may increase the dose to 10 mcg twice daily. Starting at a lower dose helps reduce stomach-related side effects.

Bydureon BCise (Exenatide Extended-Release)

• Form: Injectable

• Dosing Frequency: Once weekly

• Uses: Type 2 diabetes.

• Additional Benefits: Extended-release formulation provides a more convenient dosing schedule compared to Byetta.

Unlike Byetta, Bydureon BCise has a fixed dose of 2 mg administered once weekly, on the same day each week. It can be taken at any time of day, with or without food.

Mounjaro (Tirzepatide)

• Form: Injectable

• Dosing Frequency: Once weekly

• Uses: Type 2 diabetes.

• Additional Benefits: Dual action as it targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, potentially offering enhanced efficacy in blood sugar control.

Mounjaro is not approved for weight loss; however, its active ingredient, tirzepatide, is approved for weight loss under the brand name Zepbound.

Typically, Mounjaro’s starting dose is 2.5 mg once weekly for four weeks. By week 5, the dosage is often increased to 5 mg once weekly for another four weeks. Following week 9, if necessary for better blood sugar management, the dosage can be escalated to 7.5 mg weekly.

It's important not to increase Mounjaro doses by more than 2.5 mg every four weeks. The maximum recommended dosage is 15 mg once weekly.

Unlike Ozempic, Trulicity, or Victoza, Mounjaro is currently not approved for any heart-related uses. However, an ongoing clinical trial is assessing its effectiveness in reducing major adverse cardiovascular events in people with Type 2 diabetes. The study is anticipated to conclude in October 2024.

Key Differences and Considerations

The right GLP-1 agonist for you will likely come down to a few key factors like age, treatment goals, and underlying health conditions. Personal preferences like dosage frequency will also come into play.

1. Dosing Frequency:

   • Once weekly: Ozempic, Trulicity, Bydureon BCise, Mounjaro.

   • Once daily: Rybelsus (oral), Victoza, Saxenda.

   • Twice daily: Byetta.

2. Administration Form:

   • Injectable: All except Rybelsus (oral).

   • Oral: Rybelsus.

3. Indications:

   • Type 2 Diabetes: All medications.

4. Cardiovascular Benefits:

   • Proven cardiovascular benefits: Ozempic, Trulicity, Victoza.

5. Pediatric Use:

   • Approved for children: Victoza (for children 10 years and older).

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

This week we are continuing our mini-series on low testosterone (low T) and testosterone replacement therapy. 

Today we'll cover low T treatment options and the potential side effects of testosterone replacement therapy (TRT). All this and more in less than 5 minutes.

What are some low testosterone treatment options?

If your lab results indicate that your testosterone is low, there are several treatment options available to help increase your testosterone level. This testosterone therapy is called testosterone replacement therapy (TRT). 

TRT involves directly introducing additional testosterone into your system. Options include injections, gels, creams, troches, patches, pellets, and tablets.

Injections are typically given subcutaneously (into the fatty tissue) or intramuscularly (into the muscle), depending on your prescribed product. How often you'll receive the injection depends on the specific product too. 

Creams and gels are applied topically to the skin. Where you apply the cream or gel will depend on the product you have been prescribed. There are nasal gels that are applied inside your nose. These products must be applied 3 times a day, and you can't blow your nose for an hour after using them.

Patches are typically applied to the back, upper arm, or stomach (not a bony area or on the back of your thighs). Patches should be worn for 24 hours, and the old patch should be removed before putting on a new patch. 

Testosterone pellets are surgically implanted typically into the upper hip or buttock. It's also important to know that adjusting your dose is difficult and requires surgery. But these pellets last for 3 to 6 months.

Pills aren't as popular as other TRT because they've been associated with possible liver problems in the past. Still, it's good to know that there are testosterone pills available. 

What are the side effects or risks of TRT?

Potential side effects of TRT may include:

• Oily skin or acne
• Headache
• High blood pressure
• Hair loss
• Worsening of sleep apnea (a sleeping condition where breathing stops and starts)
• May cause prostate gland enlargement (make it difficult to urinate)
• Gynecomastia (enlargement of a man's breast tissue)
• Increased cholesterol levels
• Increased blood sugar levels
• Blood clots
• Liver damage (prolonged-high-dose use)

How often should you test your testosterone levels?

During TRT, you should test your testosterone levels at least every 90 days (or sooner if you continue to have symptoms of low T during TRT). Clinically, if you're doing well and your doctor agrees that your levels are within good ranges, you'll want to test every six months. 

It's important to remember that high testosterone can be just as dangerous as low testosterone. This is because your body will start to convert excess testosterone into estrogen to help compensate. Too much estrogen in the male body is not a good thing. It can affect your sex drive, cause erectile dysfunction, and cause excess breast tissue to grow. If left untreated, you could put yourself at risk for heart and liver problems. 

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together along with information on low testosterone and testosterone replacement therapy.

We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tip

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Argireline is a buzzword in the world of skincare, hailed for its potential to decrease wrinkles and fine lines. But what exactly is this wonder ingredient, and how does it work its magic?

Argireline, scientifically known as Acetyl Hexapeptide-8, is a man-made, peptide compound primarily used in skincare products for its anti-aging effects. Unlike invasive procedures or harsh chemicals, Argireline offers a non-invasive approach to reducing wrinkles by targeting the mechanisms that cause them.

Today we’ll talk about all about Argireline, what it is, how it works for skin health, and how to use it.

What is Argireline?

It's essentially a synthetic peptide composed of six amino acids. Its structure is designed to mimic the effects of Botulinum Toxin (Botox) but without the injections. When applied topically, Argireline works by interfering with the signals between nerves and muscles. This interference temporarily blocks muscle contractions, leading to a smoother appearance in areas prone to wrinkles, especially around the eyes and forehead.

How Does Argireline Work?

Argireline works by preventing the formation of wrinkles caused by repeated facial expressions. When we smile, frown, or squint, our facial muscles contract, eventually leading to the formation of fine lines and wrinkles over time. Argireline steps in by limiting these muscle contractions, thereby reducing the appearance of lines and wrinkles.

It blocks the release of neurotransmitters called catecholamines, which are involved in muscle contraction. In a nutshell, Argireline helps relax facial tension. This relaxation can lead to smoother skin and a reduction in the depth and appearance of fine lines.

What are the Potential Benefits of Argireline?

Reduction in Wrinkles: The most significant benefit of Argireline is its potential to reduce the appearance of wrinkles, especially those caused by facial expressions.

Non-Invasive Alternative: For individuals who prefer non-invasive methods to combat aging, Argireline offers a topical solution without the need for injections like Botox or surgeries.

Suitable for Various Skin Types: Argireline is generally well-tolerated by different skin types, making it accessible for a broader range of individuals.

Complements Other Skincare Ingredients: It can be used together with other skincare ingredients, such as antioxidants, moisturizers, hyaluronic acid, or collagen formulations, to enhance its effectiveness and overall benefits. 

What is the downside to Argireline?

While Argireline shows promise in reducing wrinkles, its effects are temporary and may vary among individuals. Consistency in application is important to help maintain its anti-aging benefits. Also, it's important to note that it might not be as effective for deeply etched wrinkles or sagging skin, which might require more invasive treatments like surgery or anchoring threads. This is because unlike hyaluronic acid, which stimulates collagen production, Argireline does not lead to significantly more collagen and elastin production in the skin.

How fast does Argireline work?

Clinical studies have revealed that Argireline has the potential to visibly diminish wrinkles within one week. Most people report a reduction in wrinkle volume, length, depth, and roughness. However, it's important to note that individual outcomes can differ, and your skin's reaction to these peptides may be different than others.

How do I use Argireline?

You can use Argireline in your daily skincare routine. You should apply the serum or cream to areas such as the forehead and between the eyes (frown lines), the corners of the eyes (crow's feet), and around the mouth (smile lines). Additionally, it can be used on the neck and the back of the hands—essentially anywhere you desire the anti-wrinkle benefits of this peptide complex.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Today, we’re exploring an important trio that often flies under the radar—blood sugar, testosterone, and metabolic health. We will discuss the connections between these key health markers and why balancing them can greatly impact your well-being. 

The Blood Sugar Connection

Let’s start with blood sugar. Most of us are familiar with how blood sugar levels affect our energy, but I want to highlight something that we often overlook: the long-term effects of chronically elevated blood sugar on our metabolic health.

When your blood sugar is constantly spiking—whether from processed foods, sugary drinks, or even excessive carbs—it leads to insulin resistance. 

As a refresher, insulin is the hormone that moves glucose from your blood into your cells. But when your body is flooded with sugar all the time, your cells start to ignore insulin, forcing your body to produce even more. Over time, this can lead to type 2 diabetes, weight gain, and even cardiovascular disease.

But here’s where it gets interesting. Blood sugar doesn’t just impact your waistline or energy levels—it also plays a key role in your hormone balance, particularly testosterone.

Testosterone’s Role in Metabolism

It’s important to know that testosterone isn’t just a ‘male hormone.’ Both men and women need testosterone for a variety of functions, especially when it comes to maintaining a healthy metabolism. Testosterone is critical for building muscle mass, which is one of the most effective ways to regulate your blood sugar.

Muscle is a metabolically active tissue, meaning it burns more calories at rest than fat. The more muscle you have, the better your body handles glucose, and the more sensitive your cells are to insulin. Essentially, healthy testosterone levels help you use blood sugar more efficiently.

But here’s the catch: when blood sugar is consistently high, it can lead to low testosterone levels, especially in men. High insulin levels suppress the production of testosterone, creating a vicious cycle of poor metabolic health, weight gain, and further hormonal imbalance. This is why metabolic health and testosterone go hand-in-hand.

How to Balance Blood Sugar and Support Testosterone

So, how do we keep blood sugar levels in check and support healthy testosterone production? I want to cover some key lifestyle changes:

1. Diet: Start by focusing on a nutrient-dense, whole-foods diet. Prioritize protein and healthy fats, which help stabilize blood sugar. You’ll want to avoid ultra-processed foods and sugars, as they are the main culprits in spiking blood sugar and promoting insulin resistance.

2. Exercise: Building muscle is essential, not just for metabolic health but for supporting testosterone levels. Resistance training, like lifting weights, is one of the best ways to increase muscle mass and improve insulin sensitivity. Even short, intense workouts can have a profound impact on your metabolic health.

3. Stress Management: Chronic stress is a major contributor to blood sugar imbalances. Cortisol, the body’s stress hormone, causes blood sugar to rise. Over time, this can contribute to insulin resistance and hormonal imbalances, including low testosterone. Practices like meditation, breathing exercises, or even just getting better sleep can help manage stress and, in turn, support your metabolic health.

4. Sleep: Speaking of sleep, poor sleep is often overlooked as a contributor to metabolic issues. Poor quality sleep reduces insulin sensitivity and lowers testosterone levels, creating another cycle of imbalance. Getting 7 to 9 hours of quality sleep is crucial for keeping your metabolism and hormones in check.

Why Metabolic Health Matters for Everyone

This connection between blood sugar, testosterone, and metabolic health isn’t just for people looking to lose weight or bulk up in the gym. Metabolic health is the foundation of overall wellness. When your blood sugar is balanced, and your hormones are functioning properly, you have more energy, a stronger immune system, and a lower risk of chronic diseases like diabetes, heart disease, and even certain cancers.

What’s more, poor metabolic health can accelerate the aging process. High insulin levels and low testosterone can lead to muscle loss, cognitive decline, and an increased risk of developing age-related diseases. So, if there’s one takeaway from this episode, it’s that managing your blood sugar and supporting healthy testosterone levels is key for longevity and overall health.

Blood sugar, testosterone, and metabolic health are deeply intertwined. If you focus on maintaining healthy blood sugar levels through proper diet, regular exercise, stress management, and good sleep, you’re setting yourself up for better hormonal balance and long-term health.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey.

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Today we are talking about peptide injections. We’ll cover the difference between subcutaneous and intramuscular injections, choosing needle length and needle gauge or “thickness”.

Several weeks ago, we talked about WHY we inject most peptides. So now we’ll cover the two common types of peptide injections.

What is the difference between a subcutaneous and intramuscular injection?

Intramuscular peptide injections are given into a muscle that has a blood supply. This allows peptides to be absorbed faster than they would be by the subcutaneous route. Intramuscular injections require a needle around 1 inch long for most adults. The correct needle length is determined by the patient’s size, age, and the amount of fat tissue in the chosen injection site. This length allows the peptides to pass through the different skin and fat layers, but not too long to risk hitting underlying nerves and bone.

The thickness of the needle is measured in millimeters and is referred to as the “gauge .” Needle gauges for intramuscular injections typically range between 22 and 25 gauge. A good way to remember needle thickness is the higher the gauge number, the finer or thinner the needle.

Intramuscular peptide injections should be given so that the needle enters your body at a 90-degree angle. This means it should be a straight injection, not given at an angle. Intramuscular injections are given in the outside of the upper arm, in the hip, in the buttocks, or in the thigh. 

Subcutaneous peptide injections aren’t injected as deep as intramuscular injections. These injections are given in the layer of fat between your skin and muscle. This area is not as richly supplied with blood vessels as your muscles. Peptides given by the subcutaneous route are absorbed more slowly than with intramuscular injections.

Subcutaneous peptide injections require a thinner, shorter needle. Needle gauges for subcutaneous injections typically range between 25 and 31 gauge with needle lengths around ¼ inch to ½ inch long. 

The needle length and needle insertion angle depend on a person’s weight and amount of fatty tissue. Subcutaneous injections can be given so that the needle enters your body at a 45 or 90-degree angle. The needle can be inserted at a 90-degree angle across pinched skin for people with a significant amount of fatty tissue. For those with minimal fatty tissue, the needle should be inserted at a 45-degree angle across pinched skin. 

Subcutaneous injections are given in the back of the upper arm, in your stomach, or in the thigh. Whether you’re giving yourself an intramuscular or subcutaneous injection, remember to try to avoid giving yourself an injection in the same place twice in a row. 

You should always speak to your healthcare provider or pharmacist about which needle length and gauge will work best for your peptide injections. 

As always, you can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide therapy information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Leave a comment.. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Today we’re diving into an interesting topic that’s been getting a lot of attention lately—linoleic acid from seed oils, and how it can influence fat cells, metabolism, and ultimately, our weight.

Today, we're not diving into a particular peptide. Instead, let’s shine the spotlight on linoleic acid, a PUFA (polyunsaturated fatty acid). Understanding how PUFA’s work is crucial for optimizing our health journey, especially when we're incorporating peptide therapy, as these fatty acids play key roles in inflammation, impacting our fat cells, metabolism, and cell structure. 

Stick around as I try to break it all down.

How do fat cells work in the body?

First, let’s take a step back and understand how fat cells work in the body. Our fat cells, also known as adipocytes, play an important role in regulating our energy balance. They store fat to be used as energy later, and they release hormones that help manage our hunger, metabolism, and inflammation.

When we consume food, particularly excess calories, our bodies store this energy in fat cells. These cells don’t just sit around passively; they grow, divide, and release various substances that help maintain homeostasis—or balance—within the body. But what happens when these fat cells are exposed to certain fats, like linoleic acid?

What is linoleic acid?

Linoleic acid is an omega-6 polyunsaturated fatty acid (PUFA). It’s essential for our bodies, meaning we need to consume it through food, because our bodies can’t produce it on their own. However, in recent years, there’s been growing concern about the overconsumption of linoleic acid, especially from processed foods containing seed oils.

You might be asking, "Where do we find this linoleic acid?" Great question! Seed oils are extracted from the seeds of plants and are often used in processed foods due to their ability to stay stable at high cooking temperatures. They are also found in salad dressings and fried foods. Additionally, linoleic acid is found in nuts and seeds, though the concentration is much lower than in seed oils.

Some of the most common seed oils include:

• Canola oil (from the seeds of the rapeseed plant)

• Sunflower oil (from sunflower seeds)

• Safflower oil (from the safflower plant)

• Soybean oil (from soybeans)

• Corn oil (from corn)

• Grapeseed oil (from grape seeds)

• Cottonseed oil (from cotton seeds)

These oils are highly refined and contain high levels of linoleic acid, which, as we discussed, is a polyunsaturated omega-6 fatty acid. While they’re widely used in cooking, baking, and processed foods, the problem arises when these oils are consumed in excess, especially in comparison to omega-3 fats like those found in fish and flaxseeds.

So what does all this linoleic acid do to our fat cells, particularly in large amounts? 

Research has shown that excessive consumption of linoleic acid can have several notable effects on fat cells.

1. Fat Cell Hypertrophy

Fat cell hypertrophy refers to the increase in the size of fat cells. When fat cells become swollen with fat, they can’t function as effectively. In fact, linoleic acid has been shown to promote fat cell enlargement. In other words, when you consume too much of it, your fat cells may grow larger than they should, potentially leading to unhealthy weight gain and obesity over time.

But there’s more. As fat cells get larger, they also produce more of the hormones and signals that regulate your metabolism. This can cause an imbalance in your body's overall fat storage and energy regulation, leading to potential metabolic issues.

2. Impact on Fat Cell Hormones

Fat cells secrete important hormones such as leptin, which regulates hunger and energy balance. However, excessive linoleic acid can alter this hormone regulation. When fat cells get too large and full of linoleic acid, they may lead to a decrease in leptin sensitivity, which can confuse the brain’s hunger signals, potentially causing overeating or poor appetite control. This, in turn, may hinder your body’s ability to regulate weight.

And it doesn’t stop there. Linoleic acid also affects adiponectin, another important hormone produced by fat cells that helps with fat breakdown and insulin sensitivity. Higher levels of linoleic acid have been linked to lower levels of adiponectin, which can result in poorer fat metabolism and higher risk for insulin resistance—a key factor in obesity and Type 2 diabetes.

3. Impacts fat cell division

Now, let’s talk about fat cell division—also known as adipogenesis. When the body does not have an excess of energy, fat cells primarily store energy in the form of fat (triglycerides) for future use. They remain relatively stable in size, and their role is to maintain energy balance by releasing stored fat when the body needs energy, such as during fasting or exercise.

In contrast, when the body has excess energy, typically from overeating, fat cells take on a more active role by expanding in size (hypertrophy) to store the surplus calories. Once existing fat cells reach their storage limit, the body may also create new fat cells (adipogenesis) to accommodate the extra energy, contributing to weight gain.

Studies suggest that excessive linoleic acid may interfere with fat cell division. This means the body could end up with fewer, but larger, fat cells. These large fat cells are not only inefficient at storing fat but are also linked to inflammation and metabolic diseases, including cardiovascular disease.

How can I reduce my linoleic acid intake?

Now, if you’re worried about how much linoleic acid you might be consuming, you're not alone. In the modern Western diet, a typical person gets a significant amount of linoleic acid from seed oils (as we mentioned earlier) that are mainly found in processed foods. While these oils aren't inherently bad in moderation, the key, is balance. The body needs both omega-3 and omega-6 fatty acids in a certain ratio, but many people today are consuming far more omega-6 than omega-3s, which can skew this balance and potentially lead to inflammation and metabolic issues.

So, what can we do about it?

Well, the first step is to be mindful of the oils you’re using. Olive oil, avocado oil, and coconut oil are all great alternatives to seed oils, as they contain healthy fats that are less likely to promote fat cell enlargement or disrupt hormone function. And of course, whole, nutrient-dense foods—like vegetables, fruits, lean proteins, and fatty fish—can help keep your body in balance, supporting healthy fat cells, metabolism, and overall well-being.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Today we are talking about MK-677, what it’s for, and its potential benefits. All this and more in less than 2 minutes. 

What is MK-677?

MK-677 also called Ibutamoren is an ORAL growth hormone-releasing peptide (GHRP) peptide therapy. We’ve talked about these types of peptides before when we discussed Ipamorelin. Unlike Ipamorelin it’s taken by mouth and remains active for about 24 hours. 

MK-677 increases growth hormone levels resulting in increased energy, lean muscle mass and strength, and improved sleep and muscle recovery. 

It can also help decrease body fat by stimulating the production of insulin-like growth factor (or IGF-1). IGF-1 is a hormone that’s similar in molecular structure to insulin and plays an important role in childhood growth and has anabolic effects (or muscle-building effects) in adults. 

MK-677 works by stimulating the pituitary gland to release growth hormone. The body will then increase its own growth hormone production. Over time, the body repairs itself and the aging process is slowed down. 

How to use?

MK-677 is given as an oral tablet by mouth before bedtime or at dinner with a large meal. It’s suggested that this peptide be used no longer than 8 to 12 weeks. Studies suggest prolonged use does not provide continuous release of growth hormone. Further studies are needed.

Possible side effects?

MK-677 also causes an increase in ghrelin, the “hunger hormone”. This hormone is released by the stomach and small intestine and stimulates appetite and promotes fat storage. But this hunger side effect tends to lessen when it’s taken at bedtime or with a large meal.

You should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together in one place.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media. Feel free to leave a comment. How have you found peptides to help you? What’s worked for you? What’s not? What have you learned about yourself? And subscribe to our podcast. Have a happy, healthy week!

Today we're going to talk about BPC 157 and joint health. 

Problems with your joints can happen at any age. But when we get older, our joints become stiffer and less flexible. The fluid in our joints may also decrease, and the cartilage may begin to rub together and eventually wear away. These changes may lead to injuries or conditions like arthritis, tendonitis, and sprains. 

When our joints break down, it may cause inflammation in the joint space and cause stiffness and pain. Not only can joint stiffness and pain cause physical limitations that may interfere with your work or personal life (e.g., inability to kneel, sit or stand for long periods, or climb stairs), but it can also cause some people to lose their independence and cause extreme stress in their life.

How do you manage joint health with BPC 157?

So you've tried everything to help your joint pain or stiffness. First, you've tried to maintain a healthy weight. You've focused on eating a diverse range of foods, particularly high-fiber foods like broccoli, sweet potato, and quinoa, to help you feel full longer. You've limited saturated fats from your diet (e.g., fried foods, red meat, whole-fat dairy products), avoid trans fats (e.g., processed meats), and avoid ultra-processed foods high in refined sugars like soda, candy, and cereal.

You've also incorporated anti-inflammatory foods into your diet (e.g., berries, fatty fish, and leafy green vegetables) to help fight inflammation in your joints. And you drink plenty of water throughout the day to help make the synovial fluid in your joints.

You even get regular exercise to help keep your joints lubricated and stretch before and after each workout to help avoid unnecessary injuries.

No matter what you've tried, you continue to have joint pain and stiffness. This is where BPC 157 may help. 

BPC 157, or Body Protection Compound 157, is a peptide derived from stomach acid. It works by decreasing inflammation and increasing blood flow to damaged tissues. It speeds up the healing of wounds, tendons, ligaments, bone injuries, your nervous system, and even the digestive tract. 

How do you use BPC 157?

For general use, BPC 157 can be taken either orally or inject the peptides under the skin (subcutaneously) once daily. If injury-specific, dosing is SPLIT into TWICE DAILY injections under the skin, specifically around the injury site.

Possible side effects include redness, itching, or swelling at the injection site. You should tell your healthcare provider about any side effects you experience. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Today we're going to talk about what causes hair loss and different peptide therapy options available to help with hair growth. 

It's normal to lose about 50 to 100 hairs per day. But losing more than that may mean you have excess hair shedding, and you'll start to see signs of hair thinning and hair loss. This is when most people might see a thinner ponytail, bald spots, a receding hairline, or a widening hair part. 

There are different causes of hair loss. Some people are more prone to hair thinning and hair loss than others based on genetics. Other causes of hair loss include:

• Health conditions like PCOS, lupus, or hypothyroidism

• Hormonal changes (e.g., during pregnancy or menopause)

• Stressful life events like having surgery or being diagnosed with a serious illness

• Certain medications like statins, ACE inhibitors, cimetidine, colchicine, isotretinoin, testosterone, and progesterone

• Nutritional deficiencies like low levels of iron, vitamin D, and zinc

Infections can also affect your scalp and cause hair loss. This can happen when bacteria or fungi infect hair follicles. But most scalp infections are curable with the right antibiotic or antifungal treatment. 

But, most people will notice hair loss and hair thinning as they age. This is because you produce less oil in your scalp as you age, making your hair weak and fragile. 

So what is the importance of this?

Depending on the cause, hair loss may be curable or reversible, so it's important to let your healthcare provider know when you notice signs of hair loss or hair thinning. Once your provider understands the cause, they can give you treatment options that work best for you. The sooner you start the right treatment, the better your chance of regrowing your hair and having less hair loss. 

What peptides may help with hair loss and hair thinning?

GHK-Cu or copper peptides prevent further hair loss and thinning in men and women by blocking an enzyme that converts testosterone into DHT. This hormone can cause hair follicles to become weaker and thinner over time. Copper peptide shampoos should be used with a scalp exfoliator with each shower. Most copper peptide hair products are water-based serums or foams.

PTD-DMB, short for protein transduction domain-Dvl binding motif. In simple terms, this peptide prevents hair loss and promotes the growth of new hair follicles. It does this by blocking proteins that prevent follicle development and hair regrowth. The product is typically available as a topical foam or spray and should be applied daily.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Today we’re diving into a fascinating peptide that’s making waves in the health and fitness community: MOTS-c. If you're curious about mitochondrial health, fat loss, or boosting energy levels, you’ll definitely want to stick around for this one.

What is MOTS-c?

Let’s start with the basics – What exactly is MOTS-c?

It’s a small peptide derived from the mitochondria, which are the powerhouses of our cells. While the mitochondria are primarily known for generating energy, they also play a crucial role in regulating metabolism, aging, and even physical performance.

MOTS-c is encoded by mitochondrial DNA, which makes it quite unique compared to most peptides, which are usually encoded by nuclear DNA. This peptide helps our bodies adapt to stress, regulate energy production, and maintain metabolic balance—especially when it comes to burning fat and improving overall endurance.

How Does MOTS-c Work?

Now that we know what MOTS-c is, let’s talk about how it works in the body.

MOTS-c primarily acts by targeting the mitochondria, which are essential for energy production. As we age or face stressors like exercise, diet, or illness, mitochondrial function can begin to decline. MOTS-c helps maintain mitochondrial efficiency, essentially acting as a "booster" to ensure that our cells keep producing energy optimally.

What’s more, MOTS-c helps with metabolic regulation by improving how our body processes glucose and fats. This leads to enhanced endurance, fat burning, and overall energy levels. By improving mitochondrial function, MOTS-c also helps support metabolic flexibility, allowing your body to switch between burning carbs and fat more effectively based on activity levels or diet.

Potential Benefits of MOTS-c

So, what are the potential benefits of using MOTS-c in peptide therapy? There are several exciting advantages:

1. Enhanced Energy Production: By improving mitochondrial efficiency, MOTS-c can boost your overall energy levels. This makes it a popular option for those who feel fatigued or run down.

2. Increased Fat Burning: MOTS-c has shown potential in improving fat metabolism. By enhancing your body’s ability to burn fat more effectively, it could aid in weight loss or help athletes achieve better body composition.

3. Improved Endurance: Thanks to its impact on mitochondrial function, MOTS-c can improve physical performance by increasing stamina and endurance during exercise. This makes it popular among athletes or anyone looking to push their physical limits.

4. Regulation of Glucose and Insulin: MOTS-c plays a role in insulin sensitivity and glucose regulation. This could be particularly beneficial for individuals managing metabolic conditions, such as pre-diabetes or Type 2 diabetes, by improving their body’s response to blood sugar.

5. Anti-Aging Potential: Since MOTS-c helps maintain mitochondrial health, it’s thought to have anti-aging effects. By improving mitochondrial function, MOTS-c could help mitigate some of the cellular decline associated with aging, promoting overall vitality.

6. Improved Muscle Function and Recovery: Because MOTS-c helps with energy production and endurance, users often report better muscle function and faster recovery after exercise.

Potential Side Effects and Warnings of MOTS-c

While MOTS-c has some promising benefits, as with any therapy, it’s essential to understand the potential side effects and risks.

1. Lack of Long-Term Research: While preliminary studies are promising, there’s still limited research on the long-term effects of MOTS-c peptide therapy. Most studies have been conducted in animal models, and human clinical trials are still ongoing.

2. Metabolic Imbalance: MOTS-c’s impact on metabolism might not be suitable for everyone. People with pre-existing metabolic conditions or those on medications that regulate glucose or insulin should consult a healthcare provider before starting MOTS-c therapy, as it may affect how their body handles glucose or fat metabolism.

3. Hormonal Disruption: Since MOTS-c can influence metabolic pathways, there’s a possibility that it could indirectly impact hormones that regulate metabolism, appetite, and energy storage. Careful monitoring is essential if you decide to use this peptide for therapy.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Testosterone is a sex hormone made predominantly in the testicles that helps men develop sexually and physically. Hormones are chemicals that carry messages in your bloodstream to the rest of your body. They tell your body what to do and when to do it.  

But it's important to know that everyone has testosterone. It plays a major role in regulating a number of things in women's bodies too, but we're going to focus on testosterone in the context of the male body.

What does testosterone do in your body?

Testosterone plays a key role in regulating cholesterol, blood sugar, and fat levels. It also helps keep our bones strong, build muscle, boosts sex drive, and promotes body and facial hair growth. It can even affect sperm count and mood.

How does your body make testosterone?

Messages are sent from your brain to your pituitary gland. The pituitary gland sends a message to the testes to make testosterone. A "feedback loop" closely regulates the amount of testosterone in the blood. When testosterone levels rise too high, the brain sends a message to the pituitary gland to lower testosterone production.

What happens to your testosterone levels over time?

As men age, their testosterone levels naturally decrease. Peak testosterone levels happen during puberty. Typically men over 30 begin to experience a gradual decrease in testosterone levels where testosterone production decreases about 1% to 2% each year. In addition to age, lifestyle, environmental factors, and overall health contribute to the natural decline in testosterone levels.

Poor health or underlying medical conditions may contribute to testosterone levels decreasing. This includes things like:

• Injury or infection of the testicles
• Alcoholism
• Obesity
• Type 2 diabetes
• Certain genetic and autoimmune conditions (e.g., Klinefelter Syndrome, lupus, rheumatoid arthritis)
• Tumors of the pituitary gland or hypothalamus
• Specific cancer treatments (e.g., chemotherapy, radiation)
• Certain medications (e.g., opioids, prednisone)
• Plastic-leaching PCBs (polychlorinated biphenyls)- resemble estrogen (found in certain fish, dairy products, and animal fat)

Thanks again for listening! You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

In today’s episode, we’re diving into Follistatin 344. Whether you’re interested in performance enhancement, muscle growth, or just curious about the science behind peptide therapies, this episode is for you.

What is Follistatin 344?

Let’s start with the basics – what exactly is Follistatin 344?

Follistatin 344 is a naturally occurring protein in the human body, specifically a variant of the follistatin protein. Follistatin itself plays a crucial role in regulating various biological processes, most notably muscle growth and the regulation of myostatin, which is a negative regulator of muscle development. Follistatin 344 is a synthetic form of this protein and is often used in peptide therapy for its muscle-building properties.

Is Follistatin 344 a peptide?

You would be right to point out that the typical definition of a peptide is a chain of amino acids that is usually 50 amino acids or fewer. By this standard, Follistatin 344 technically exceeds the usual peptide range, as it is a protein fragment consisting of 344 amino acids. This is much larger than what would typically be classified as a peptide.

Follistatin 344 is still often referred to as a "peptide" in certain contexts, especially within the realm of peptide therapy and bodybuilding communities. This is because it's a synthetic fragment of a larger protein (follistatin), and it operates in a manner similar to smaller peptides that influence biological processes like muscle growth.

So, while it's not a "peptide" by the strictest definition, in many practical uses, it is referred to as such due to its role in peptide therapy and its functional characteristics similar to smaller peptides.

How Does Follistatin 344 Work?

Now, let’s talk about how Follistatin 344 works within the body.

Myostatin is a negative regulator of muscle growth. It essentially acts as a ‘brake’ on muscle tissue, limiting how much muscle you can build. In individuals with high myostatin levels, muscle growth is naturally suppressed. This is where Follistatin 344 comes in.

Follistatin 344 binds to myostatin and prevents it from exerting its inhibitory effects on muscle development. This leads to increased muscle mass, strength, and performance. The action of Follistatin 344 is similar to lifting the restrictions on muscle growth, essentially removing the natural “limiters” that might otherwise hinder progress.

Potential Benefits of Follistatin 344

So, why might someone be interested in using Follistatin 344? What are the potential benefits?

1. Increased Muscle Mass: By inhibiting myostatin, Follistatin 344 promotes muscle growth. This makes it popular among bodybuilders and athletes who are looking to increase lean muscle mass without the use of traditional anabolic steroids.

2. Improved Muscle Strength and Performance: Along with muscle mass, strength can also improve as muscle tissue is allowed to grow more effectively. This can translate into better performance in sports and physical activities.

3. Faster Recovery: Some users report faster recovery times from intense workouts or injuries. This could be due to the increased muscle repair and regeneration that Follistatin 344 promotes.

4. Fat Loss: Follistatin 344 may also indirectly support fat loss. As muscle mass increases, the body’s metabolism tends to accelerate, which could lead to more efficient fat burning.

5. Potential for Anti-Aging Benefits: There’s ongoing research into the potential for Follistatin 344 to slow age-related muscle loss. As we age, we naturally lose muscle mass and strength, so this peptide could potentially help mitigate these effects.

Potential Side Effects and Warnings

While Follistatin 344 has promising benefits, like any therapy, it’s important to be aware of potential side effects and warnings.

1. Unknown Long-Term Effects: As with many peptide therapies, the long-term effects of using Follistatin 344 are not yet fully understood. Most research has been done in animal models, and human studies are still relatively limited. As a result, the long-term safety profile remains unclear.

2. Muscle Imbalance: Because Follistatin 344 inhibits myostatin, there’s the possibility of muscle imbalances. Overuse of this peptide could lead to muscle growth in certain areas of the body, while other muscles may not develop as effectively.  This could result in a distorted appearance or even strain on the body’s natural systems, including the cardiovascular system.

3. Potential Impact on Other Growth Factors: Follistatin also regulates other growth factors in the body. There could be unintended effects on areas like bone growth, fat distribution, and organ function. More research is needed to understand these potential risks.

4. Hormonal Disruption: Peptides like Follistatin 344 interact with various hormonal pathways in the body, so improper use could potentially lead to hormonal imbalances. It’s important to approach peptide therapy with caution and consult with a healthcare professional before starting any new regimen.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Have you noticed the buzz within the beauty industry over copper peptides? Considering the benefits, there’s no surprise. Copper peptides are well-known in the skin and hair care world as skin and hair-restoring peptides. 

Today, we're going to focus on copper peptides. What they are, how they improve the texture of your skin and help with hair growth, and much more.

What are copper peptides?

The naturally occurring copper complex first identified in human plasma is called GHK-Cu. It's since been found in saliva and urine. This specific copper peptide has many roles in your body, from fighting inflammation to stimulating hair growth. Copper peptides are listed on ingredient labels as either GHK-Cu, Copper Tripeptide-1, Copper Lysinate, Copper Prolinate, or Copper Gluconate.

How do copper peptides work?

Copper peptides improve skin firmness and smoothness and reduce fine lines and wrinkles by stimulating collagen and elastin synthesis in skin cells. This is helpful for people looking to get rid of dark spots and fine lines.  

Copper peptides also help prevent further hair loss in men and women by blocking an enzyme that converts testosterone into DHT. This hormone can cause hair follicles to become weaker and thinner over time. This is helpful for people with thinning hair.

Copper peptides also promote wound healing by decreasing inflammation post-tissue injury and by removing damaged and scar tissue to generate new, healthy tissue. If your acne prone, copper peptides may help with scarring and redness caused by inflammation and can even help with breakouts by reducing bacteria on the skin.

How are copper peptides used?

Copper peptide skin and hair products are applied topically twice daily. Many types of products are commercially available. Most copper peptide skin care products are water-based serums and creams. Most copper peptide hair products are water-based serums or foams.

What are the potential side effects of copper peptides?

People with sensitive skin may experience skin irritation when using copper peptides. You should stop using the product if you experience a rash or redness that gets worse or won't go away.

Who should not use copper peptides?

Ingredients like retinol, vitamin C, and alpha-hydroxy acids (AHAs) in other skincare products can decrease the overall effectiveness of copper peptides. So make sure to check your skincare products for these ingredients, so your copper peptides work correctly.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

Today I have some exciting news to share. I’ve recently opened a peptide and wellness clinic, Bay Islands Fitness And Transformation Clinic (BIFAT Clinic), on the beautiful island of Roatán, Honduras, with my husband. 

Our goal is to offer a personalized approach to weight loss and wellness using peptide therapies.

As many of you may already know, with the latest weight loss trend that everyone is buzzing about on social media, many people have reported dramatic results with semaglutide therapy. 

Unfortunately, the heightened interest in semaglutide has led to supply chain issues and shortages that are affecting people who rely on it for weight loss (Wegovy) and type 2 diabetes (Ozempic). At BIFAT Clinic, we’ve partnered with a cGMP-certified, FDA-registered, peptide API manufacturer, so we’ll always have safe, quality peptides available.

Another benefit for our clients will be the reduced costs compared to markets in America. Semaglutide doesn’t come cheap. The cash price of Wegovy (without insurance) is about $1800 for a 28-day supply. And, sadly, the Affordable Care Act doesn’t require health plans to cover obesity-related medications. So while your plan may cover some types of obesity-related treatments or medications, the amount of coverage you’ll receive depends on your specific plan and your prescription coverage. Most people are left to pay the full cash price of the medication. 

And let’s be real, who can afford that? We believe that everyone should have access to safe, affordable peptides with transparent pricing. We take pride in providing the most competitive pricing around. 

But how are we able to do this? Well, it’s simple. 

1. There are no middlemen. 

We don’t use pharmacies. We negotiate and partner directly with a peptide manufacturer to provide safe, quality peptides to get the best possible price. Then, we show you exactly how much you’ll pay for your monthly peptide treatments on our website. Our prices will always be transparent, and you won’t be surprised by hidden fees. We’ll also supply you with all the supplies you need to get started on your peptide journey.

2. We’re established in Próspera. 

The Próspera Platform is a digital governance platform and business ecosystem with a legal and regulatory environment designed to promote economic growth for Honduras and promote innovation. This allows us to offer our products at highly competitive rates.

We believe with Próspera, we can give our clients the best products and turn our best ideas into a reality for the people of Honduras.

If you’ve made changes to the way you eat and have increased your physical activity but still struggle to lose weight, you may be a candidate for semaglutide injections at BIFAT Clinic.

You can work with me, the healthcare provider at BIFAT Clinic, to see if semaglutide is right for you in addition to lifestyle changes, including a healthy diet and exercise.

If you’re ready to start your personalized approach to weight loss and wellness, we’d love to help you. To learn more about BIFAT Clinic and our offerings, visit our website at bifat.life or contact us at WhatsApp at +504 3183 8381. We’re also available by email at info@bifat.life. Our office is located in the Pristine Bay Beach Club in French Harbour in Roatán, Honduras. 

Thanks again for listening to The Peptide Podcast. Have a happy, healthy week! We hope to see you soon!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Losing weight can be a challenging journey, especially for people who have relied on medications like semaglutide to help with their weight loss efforts. While medications like semaglutide can be effective tools for achieving initial weight loss goals, discontinuing them may raise concerns about how to keep the weight off long-term. 

In this podcast, we’ll talk about tips and strategies you can use to maintain weight loss even after stopping such medications.

1. Establish Healthy Habits

Building sustainable lifestyle habits is essential for maintaining weight loss. Focus on incorporating nutritious whole foods, such as fruits, vegetables, lean proteins (e.g., legumes, nuts, fresh fish, tofu, or lean cuts of meat), and whole grains into your diet. Aim for balanced meals that provide adequate nutrients and sustained energy while keeping you feeling full. Try to avoid ultra-processed foods like soda, candy, and cereal. These foods are typically higher in sugar and can leave you feeling tired and hungry.

2. Prioritize Physical Activity

Regular exercise is crucial for weight maintenance and overall health. Find activities you enjoy and make them a regular part of your routine. Whether it's walking, jogging, swimming, or yoga, aim for at least 150 minutes of moderate-intensity exercise each week or 75 minutes of vigorous exercise weekly.

3. Monitor Portion Sizes

Be mindful of portion sizes to prevent overeating. Use smaller plates and utensils to help control portion sizes visually. Pay attention to hunger and fullness cues, and stop eating when you feel satisfied, rather than “stuffed”.

4. Keep a Food Journal

Tracking your food intake can help you stay accountable and identify patterns or triggers that may lead to overeating. Consider using a food journal or a mobile app to record what you eat and drink throughout the day.

5. Practice Mindful Eating

Practice mindful eating by paying attention to the sensory experience of eating, such as the taste, texture, and smell of food. Eat slowly, savoring each bite, and avoid distractions like television or smartphones while eating. This can help prevent overeating.

6. Manage Stress

Stress can trigger emotional eating and sabotage weight loss efforts. When we’re stressed, our bodies release cortisol, a hormone that increases appetite. Find healthy ways to manage stress, such as meditation, deep breathing exercises, yoga, or spending time in nature. Engaging in hobbies or activities you enjoy can also help reduce stress levels.

7. Get Adequate Sleep

Prioritize quality sleep, as inadequate sleep can disrupt hunger hormones like leptin and ghrelin, which can increase hunger and cravings for unhealthy foods. Aim for 7-9 hours of sleep per night and establish a consistent sleep schedule.

8. Stay Hydrated

Drink plenty of water throughout the day to stay hydrated and prevent dehydration, which can sometimes be mistaken for hunger. Limit sugary beverages and opt for water, herbal tea, or sparkling water instead.

9. Seek Support

Enlist the support of friends, family members, or a support group to help you stay motivated and accountable on your weight maintenance journey. Surround yourself with positive influences who encourage and support your goals. They can help encourage you and keep you accountable during difficult times.

10. Plan Ahead

Meal planning and prepping can be very important for weight loss, especially when life gets busy. Take the time to plan your meals and snacks for the week to save time and prevent impulse eating. Stock your pantries with healthy food options to avoid temptations.

11. Be Patient and Persistent

Remember that maintaining weight loss is a lifelong journey, and there will be ups and downs along the way. Be patient with yourself and stay committed to your goals, even if progress is slower than expected. Celebrate your successes, no matter how small, and keep moving forward. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Today, we’re talking about sermorelin peptide therapy, an emerging peptide therapy option that’s gaining attention for its potential benefits in anti-aging, muscle health, and overall vitality. 

Whether you’ve heard about it before or are learning about it for the first time, this episode will break down exactly what sermorelin is, how it works, and why some people are turning to it for a boost in their health. Let’s dive right in!

What is Sermorelin?

Sermorelin is a synthetic peptide that mimics the naturally occurring hormone growth hormone-releasing hormone (GHRH), which stimulates the pituitary gland to release growth hormone (GH). Growth hormone is important for various functions in the body, including growth during childhood, metabolism, muscle and bone health, and tissue repair.

As we age, our natural production of growth hormone declines, which can contribute to symptoms like reduced muscle mass, increased body fat, lower energy levels, and other signs of aging. Sermorelin therapy is often used to boost the body’s natural production of growth hormone, rather than injecting synthetic growth hormone directly.

How Does Sermorelin Work?

Unlike traditional growth hormone replacement therapies, where synthetic growth hormone is injected directly into the body, sermorelin therapy encourages your body to ramp up its own production of growth hormone. This is often seen as a more natural approach, with fewer potential risks associated with long-term synthetic growth hormone use.

Typically, sermorelin is administered via subcutaneous injection (injected under the skin) given in the belly or upper thigh once a day or three to five times per week. The goal is to restore growth hormone levels to a more youthful range, improving overall health and well-being.

Potential Benefits of Sermorelin Therapy

So, what can sermorelin peptide therapy do for you? While results can vary, some of the potential benefits include:

1. Improved Muscle Mass and Strength: Growth hormone plays a key role in muscle growth, and as sermorelin stimulates the pituitary to release more of it, many patients report an increase in muscle mass and strength over time.

2. Fat Reduction: Sermorelin may help increase fat burning and promote lean muscle development, which can aid in weight loss and fat loss.

3. Better Sleep Quality: Growth hormone is linked to deeper, more restful sleep. Many people undergoing sermorelin therapy notice an improvement in sleep patterns.

4. Enhanced Energy Levels: With increased growth hormone production, some individuals experience a boost in energy, stamina, and overall vitality.

5. Improved Skin Tone and Elasticity: Sermorelin may help stimulate the production of collagen, leading to firmer, more youthful-looking skin.

6. Faster Recovery and Healing: Increased growth hormone levels can help with the repair of tissues and muscles, speeding up recovery from injuries or workouts.

7. Better Mood and Mental Clarity: Some users report enhanced cognitive function, better mood, and a clearer mind, likely due to the overall improvement in physical health and hormone balance.

Potential Side Effects and Risks

As with any treatment, sermorelin peptide therapy comes with its own set of potential side effects and risks. Most people tolerate the therapy well, but some may experience mild side effects, such as:

• Injection site reactions: Redness, swelling, or irritation at the site of injection.

• Headaches: Some people report headaches, particularly when starting therapy.

• Flushing or dizziness: A warm, flushed feeling or dizziness may occur, though it’s typically short-lived.

• Joint or muscle pain: Occasionally, users may experience discomfort in muscles or joints, especially in the early stages of therapy.

• Water retention: Some people might notice mild swelling or water retention.

In rare cases, there can be more serious side effects, such as excessive growth hormone levels, which could lead to conditions like carpal tunnel syndrome, diabetes, and  joint enlargement. It’s important to have regular check-ups with a healthcare provider to monitor any side effects and ensure the treatment is working as intended.

Additionally, since sermorelin stimulates the body’s natural production of growth hormone, it’s important for individuals to be screened for underlying medical conditions such as pituitary gland issues or active cancer, as these could be aggravated by the therapy.

If you're interested in exploring sermorelin therapy, talk to a healthcare professional who specializes in hormone replacement or peptide therapies to see if it's right for you.

Thanks for listening to The Peptide Podcast. If you found this episode helpful, be sure to subscribe and leave a review. And as always, have a happy, healthy week.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

A while back, we did a mini-series on peptides and sexual wellness. We covered PT-141 (bremelanotide), a peptide therapy used to help women and men with low sex drive. And Kisspeptin-10, a peptide that helps with increased arousal and may help with infertility.

But we really didn't focus on what causes a low sex drive. So today, we'll touch on the possible mental and physical causes that may affect your sex drive, but we'll focus on medications that may lead to a decreased interest in sex.

It's important to know that a low sex drive can affect both men and women. Medical conditions like depression, hypothyroidism, diabetes, and high blood pressure, may all cause a low sex drive. Even hormonal changes (e.g., during pregnancy, after childbirth, or while breastfeeding) can decrease interest in sex. And some people who use alcohol, have relationship issues, or certain infections (e.g., vaginal yeast infections, urinary tract infections) have a low sex drive.

Certain medications may cause low sex drive as a side effect. But remember that not everyone taking certain medications will have the same issues. 

Some antidepressants and antipsychotics are more likely to cause a low sex drive than others. For example, selective serotonin reuptake inhibitors (SSRIs) like Paxil, Zoloft, and Proac are more likely to cause a low sex drive than Wellbutrin or Remeron. While older antipsychotics like Haldol, used to treat schizophrenia and bipolar disorder, are more likely to cause a low sex drive than Risperdal. 

Benzodiazepines like Xanax, Ativan, and Valium, used to treat anxiety and seizure disorder, can lower your sex drive.

Many people with heart failure report having a low sex drive. This is because people with heart failure need different medications to reduce how fast or hard their heart has to work and medications that get rid of extra fluid. Unfortunately, some heart failure medications like Digoxin, Spironolactone, beta-blockers, and other water pills like hydrochlorothiazide can lower their sex drive.

Acid reflux or "heartburn" happens when stomach acid travels back into the esophagus. And people who take medications for "heartburn" (e.g., Pepcid and Zantac) have reported a lower sex drive.

Even medications that affect sex hormones (e.g., estrogen, testosterone, and progesterone) can decrease libido. Examples of these medications include birth control and Lupron (used to treat prostate cancer).

And lastly, people who use opioids like Norco and Ultram to treat pain can also have a lower sexual desire.

How to improve sex drive caused by medications?

Always talk to your healthcare provider first. They can determine if your low sex drive is due to your medications or if there's another cause, like an infection or hormonal changes. If your medication is causing a low sex drive, your healthcare provider may have you stop the medication if it's not needed. Or they may switch you to an alternate medication that doesn't cause a low sex drive. But don't stop your medication without speaking to your healthcare provider first.

Your healthcare provider may suggest other medications or peptides like PT-141 or Kisspeptin-10. 

What is PT-141?

PT-141 (bremelanotide) is a melanocortin receptor agonist peptide. Melanocortin is a natural hormone in your body that works on receptors in your brain and nervous system to cause sexual arousal and influence sexual behavior. However, we don't know exactly how it works to improve sex drive. It can also work on receptors in cells that produce skin color (melanocytes).

You may know PT-141 as Vyleesi. This medication was originally FDA-approved in 2019 to help low sex drive in women who haven't gone through menopause yet. While it's not approved for low sex drive in men, some may use it off-label. 

In these cases, men also use PT-141 to help improve erections, libido, sex drive, and performance.

What is Kisspeptin-10?

Kisspeptin-10 is a neuropeptide involved in reproduction, sexual behavior, and sexual attraction. It helps increase activity in the brain associated with sexual attraction and arousal. 

Kisspeptin-10 also stimulates the hypothalamus to release gonadotropin-releasing hormone (GnRH), which in turn signals the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones play a role in the production of both testosterone and estradiol. 

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

In today’s episode, we’re diving into an exciting topic: how GLP-1 agonists, like Ozempic and Wegovy, are not only transforming metabolic health but also influencing the gut microbiome. We'll explore the science behind it and practical ways to optimize your health.

What Are GLP-1 Agonists?
GLP-1 agonists are medications initially developed to manage diabetes, but they've gained widespread attention for their ability to support weight loss and improve metabolic health. These medications mimic the natural hormone GLP-1, which plays a crucial role in regulating insulin secretion, appetite, and blood sugar.

So, What Exactly Is the Gut Microbiome?
Now that we’ve covered GLP-1 agonists, let’s shift gears and talk about something equally fascinating: the gut microbiome. This refers to the community of bacteria living in your digestive tract, and it’s essential for not just digestion, but also immune function and mental health. The state of your microbiome can influence many aspects of overall health, including your metabolism.

How Do Obesogenic Bacteria Work, and What Impact Do They Have on Our Bodies?
Speaking of the microbiome, let’s look at a specific group of bacteria—obesogenic bacteria. These microbes are particularly skilled at extracting extra calories from food. For example, some gut bacteria break down dietary fiber into short-chain fatty acids (SCFAs), which can then be used for energy. But if these calories aren’t burned off, they get stored as fat, contributing to weight gain.

This imbalance can disrupt the body’s energy management. When obesogenic bacteria extract more calories than the body needs, it can overwhelm the system and result in fat storage. This not only affects our waistlines but can also throw off hormones like insulin, leptin, and ghrelin—key players in regulating hunger, fullness, and fat storage. An imbalance in these hormones can lead to issues like high blood sugar and constant hunger, making it harder to maintain a healthy weight.

When your gut microbiome is out of balance, a condition called dysbiosis, it often leads to low-grade chronic inflammation, which is linked to both weight gain and metabolic problems.

How Do GLP-1 Agonists Affect Our Gut Health?
So, how do GLP-1 agonists come into play here? These medications, like semaglutide, can shift the balance of gut bacteria by reducing the number of obesogenic bacteria and promoting healthier strains. This shift helps improve how the body manages hunger, blood sugar, and fat storage, all while reducing inflammation. One of the ways this happens is by increasing sodium butyrate, a short-chain fatty acid produced by gut bacteria that supports gut health and reduces inflammation.

This transformation in the gut microbiome might explain why GLP-1 agonists are so effective for weight loss and overall health improvement.

How Can I Support Gut Health?
If you’re already on a GLP-1 medication or considering one, you’ll want to support your gut health alongside your treatment. One of the best ways to do this is by focusing on a diverse diet, rich in fiber, prebiotics, and fermented foods, all of which nourish beneficial bacteria. Avoiding ultra-processed foods and excess sugars can help keep your microbiome in balance.

In addition, staying hydrated, managing stress, and considering probiotics or other gut health supplements—especially after antibiotics—can give your gut an extra boost.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Last week, we discussed the potential for semaglutide to cause diarrhea and ways to help get relief. Today I want to talk about how semaglutide can cause constipation and everything you should know to manage your semaglutide-related constipation. 

Why does semaglutide cause constipation?

Constipation can happen with semaglutide, but it tends to be less common than diarrhea. Up to 12% of people taking it for type 2 diabetes and 24% of people taking it for weight loss reported constipation in clinical trials. Understanding the causes of constipation from semaglutide and learning how to manage it is important for people using it.

Like diarrhea, you're more likely to experience constipation with higher doses of semaglutide, and the good news is that this side effect usually goes away over time as your body gets used to the medication.

It's not exactly clear why semaglutide causes constipation, but research suggests that it has to do with how the medication works. Because semaglutide slows down how fast food leaves your stomach, people feel fuller longer and tend to eat and drink less. Not getting enough fluid can cause constipation because there is less liquid in the stool, making it harder for you to have a bowel movement. 

Semaglutide also causes your pancreas to release insulin, which lowers your blood glucose (sugar) and helps your cells use glucose from the food you've eaten. This is helpful because extra glucose your cells don't use is stored as fat, which is why high blood sugar can lead to weight gain. But keep in mind that insulin also slows down your gut, which means you may have a bowel movement less often.

How do you manage constipation from semaglutide?

Dietary Changes: Add more fiber-rich foods like whole fruits (raspberries, apples, and bananas) and vegetables like broccoli, sweet potato, and lentils. It's recommended to start with 2 servings per day. Most adults should aim for 25 to 30 grams or more every day. You'll want to start slow because eating too much fiber can have the opposite effect and cause bloating, gassiness, and more constipation. 

Stay active: Reduced physical activity can lead to constipation. Moving around can help get things moving in your gut and also relieve bloating. Try to get at least 15 minutes of physical activity during the day to help get your bowels moving.

Stay hydrated: Like diarrhea, constipation can happen if you're dehydrated. Drinking water and clear fluids will help prevent your stools from becoming hard and dry.

You can also try using the bathroom at the same time each day and make sure not to hold your poop in when you have to use the bathroom. This will help your gut get into a good rhythm. It's recommended to take your bathroom breaks about 30 minutes after you eat. This is when your gut is most active.

Over-the-counter (OTC) Remedies: Over-the-counter fiber supplements, laxatives, or stool 

softeners can be used to manage constipation. These products can help soften stools and make them easier to pass. Popular products include Dulcolax (laxative), Colace (stool softener), and Metamucil (fiber supplement).

Probiotics: Probiotic supplements or probiotic-rich foods like yogurt, kefir, and fermented vegetables can help regulate gut health and promote regular bowel movements. Probiotics contain beneficial bacteria that support the natural balance of the digestive system. Popular probiotics are Lactobacillus and Bifidobacterium. 

Make sure to keep track of your constipation symptoms, including the frequency of bowel movements and any discomfort. This information can be valuable for your healthcare provider in adjusting your treatment plan. And let your provider know if you are unable to eat, have stomach pain, and experience vomiting.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It's vegan, paleo, and keto-friendly.

Today we’re going to talk about how to manage the most common semaglutide side effects.

When you’re taking semaglutide, you may experience side effects. Some side effects can be bothersome and make the peptide difficult to take. Remember, side effects can happen to anyone using semaglutide, but not everyone experiences them the same way. But the good news is they usually go away with time. 

Nausea and vomiting

Nausea is the most common side effect of semaglutide. Up to 44% of people taking semaglutide for weight loss reported having nausea. While 24% reported vomiting. You’re likely to experience these side effects with higher doses of semaglutide. This is why your healthcare provider slowly raises your dose every 4 weeks to minimize these effects. 

Eating smaller meals, avoiding high-fat foods, and sipping on water or broth throughout the day can help manage potential nausea from semaglutide. 

If you experience vomiting, once you stop, start back on food slowly, beginning with clear liquids, then try mild foods like bananas, rice, and dry toast or crackers.

Diarrhea and constipation

Another common side effect of semaglutide is diarrhea. Up to 30% of people taking semaglutide for weight loss reported having diarrhea. Like nausea and vomiting, diarrhea occurs with higher doses and because your dose is slowly raised over time, this should help minimize this side effect. Constipation was reported in 24% of people.

Avoiding spicy foods, high-fiber foods (whole wheat, broccoli, granola), and dairy can help manage potential diarrhea from semaglutide. 

Stomach pain

Mild stomach pain is another common side effect affect up to 20% of people taking semgalutide for weight loss. This too should get better with time. 

It’s important to remember that you should never have severe stomach pain. This could be a sign of something more serious like gallstones or pancreatitis (inflammation of the pancreas). If you experience any of the following symptoms, contact your healthcare provider immediately:

• pain in your stomach/back with or without vomiting
• yellowing of your skin
• fever
• change in your stool color

Fatigue 

Fatigue is another common side effect, affecting up to 11% of people taking semaglutide for weight loss in clinical trials. 

It’s important to remember how semaglutide works for weight loss to understand why fatigue may happen. Semaglutide works by making you feel less hungry. If you eat less calories (energy) this may cause you to feel tired. Like all of the other possible semaglutide side effects, this feeling of fatigue should go away as your body gets used to your new eating habits. 

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

Semaglutide, a medication commonly used to treat type 2 diabetes and obesity, has gained significant attention in recent years due to its effectiveness in helping patients achieve better blood sugar control and weight management. But, some individuals who take semaglutide may experience an unpleasant side effect: heartburn (acid reflux). In this podcast, we’ll talk about why heartburn occurs with semaglutide and provide valuable insights on how to manage this side effect. 

What is the connection between semaglutide and heartburn?

Semaglutide is part of a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It works by mimicking the effects of a naturally occurring hormone called GLP-1, which helps regulate blood sugar levels and control appetite. While semaglutide has proven to be a game-changer for many patients in managing their diabetes and obesity, it can sometimes trigger heartburn.

Why do some people get heartburn with semaglutide?

Several factors contribute to the development of heartburn in people taking semaglutide. In fact, clinical studies show that about 2% of people reported symptoms of heartburn. And interestingly enough, these trials show that people are more likely to experience heartburn while taking the lower dose of semaglutide (0.5 mg weekly). Keep in mind that most reported side effects get worse with higher doses (1 mg, 1.7 mg, and 2.4 mg weekly).

Most people reported heartburn symptoms as a “burning sensation in their esophagus or throat”, indigestion, or burping.

And although it’s not known how long semaglutide-induced heartburn lasts, studies have shown that the majority of people keep taking semaglutide despite this side effect. 

It’s not exactly clear why semaglutide causes heartburn but there are a few speculations.

Delayed Gastric Emptying: Semaglutide slows down how fast food leaves your stomach. Because it slows digestion, it can help you feel full longer and faster. This is how it helps you lose weight. Because semaglutide slows down the emptying of the stomach, it can lead to the accumulation of stomach acid. This acid backup can cause heartburn symptoms.

Relaxation of the Lower Esophageal Sphincter (LES): The LES is a muscle that separates the esophagus from the stomach and prevents stomach acid from flowing back into the esophagus. When you take semaglutide, food hangs around in your stomach longer, causing the LES to relax, making it easier for stomach acid to make its way into the esophagus, leading to heartburn. 

Diet: Some individuals taking semaglutide may continue eating large meals or spicy foods. Consuming larger meals or spicy foods can exacerbate heartburn symptoms.

Nausea and vomiting: Unfortunately, the most common side effects of semaglutide are stomach-related. This can include nausea and vomiting. When you vomit, acid rises from your stomach into your esophagus, burning its lining and causing you to feel pain or discomfort (indigestion). 

How can you manage heartburn caused by semaglutide?

Experiencing heartburn while taking semaglutide doesn't mean you have to discontinue the medication. There are several effective strategies you can try to manage heartburn and continue benefiting from semaglutide's positive effects on your diabetes or weight management journey.

1. Adjust Your Eating Habits

• Eat Smaller Meals: Consuming smaller, more frequent meals can help reduce the pressure on your stomach and minimize the risk of acid reflux.

• Avoid Trigger Foods: Identify foods that trigger heartburn for you and limit or eliminate them from your diet. Common triggers include spicy foods, acidic foods, caffeine, and alcohol. Citrus fruits, tomatoes, and chocolate can also cause heartburn.

• Chew Thoroughly: Take your time when eating, and chew your food thoroughly. This can help ease the digestive process and reduce the risk of heartburn.

• Avoid late-night snacking: Refrain from eating within a few hours of bedtime to minimize the risk of nighttime heartburn.

• Stay hydrated: Drinking plenty of water can help dilute stomach acid and reduce the risk of heartburn.

2. Change your sleeping position

• If your heartburn gets worse at bedtime, try elevating the head of your bed by about 6-8 inches with a wedge. This can help prevent stomach acid from flowing into the esophagus while you sleep. Sleeping on your left side can also help keep stomach acid down. 

3. Wear loose clothing

• Tight waistbands put pressure on your stomach which can force more stomach acid into your esophagus and cause heartburn. Wearing loose pants or skirts can help relieve your symptoms.

4. Consult Your Healthcare Provider

• If heartburn persists for more than 2 weeks or becomes severe, consult your healthcare provider. They may recommend adjusting your semaglutide dosage, switching to an alternative medication, or prescribing medications to manage heartburn symptoms.

5. Try an over-the-counter heartburn medication

• Over-the-counter (OTC) antacids can provide temporary relief from heartburn symptoms by neutralizing stomach acid. Examples include Tums, Rolaids, Alka-Seltzer, and Mylanta. These medications typically start working within minutes. Other OTC medications like famotidine take a couple of hours to start working. But these medications may provide longer-lasting relief. Remember to talk with your healthcare provider before using them regularly, as they may interact with other medications you're taking.

While heartburn can be an unwelcome side effect of semaglutide, it doesn't have to deter you from reaping the benefits of this effective medication for managing type 2 diabetes and obesity. 

By making dietary and lifestyle adjustments, consulting your healthcare provider, and considering over-the-counter remedies, you can successfully manage heartburn while continuing your treatment with semaglutide. 

Remember that open communication with your healthcare team is essential to finding the right balance between managing your condition and minimizing side effects. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It’s vegan, paleo, and keto-friendly.

In the realm of regenerative medicine, BPC-157 (Body Protection Compound-157) has emerged as a promising peptide for its potential to promote healing and address inflammation. From injuries and inflammation to gut health and brain fog, BPC-157 has been shown to promote a wide range of healing properties in many animal studies. 

In this podcast, we’ll talk about the intricate mechanisms through which BPC-157 for many different health conditions.

Tissue Repair and Injuries:

• BPC-157 has been shown to accelerate tissue repair and regeneration. It works by stimulating the formation of new blood vessels, a process known as angiogenesis. This increases blood flow to the injured site in order to deliver essential nutrients and oxygen to help facilitate the healing process

• Additionally, BPC-157 modulates the activity of growth factors involved in tissue regeneration, such as VEGF (Vascular Endothelial Growth Factor) and FGF-2 (Fibroblast Growth Factor 2), thereby promoting the proliferation of fibroblasts and other cells crucial for wound healing.

Pain Caused by Inflammation and Joint Pain:

• Inflammation is a common underlying factor in many painful conditions, including back pain (e.g., muscle strains, degenerative disc disease, or arthritis) and joint pain due to inflammatory disorders (e.g., osteoarthritis or rheumatoid arthritis). 

• BPC-157 exhibits potent anti-inflammatory properties, suppressing the production of pro-inflammatory cytokines like TNF-alpha and interleukins. By dampening the inflammatory response, BPC-157 helps alleviate pain and discomfort associated with inflammation. Moreover, BPC-157 may exert protective effects on cartilage and joint tissues, contributing to its potential to manage joint pain and promote musculoskeletal health.

Gut Health:

• The gastrointestinal tract is a complex ecosystem that plays a vital role in overall health and well-being. In fact, clinical studies show that your gut health is important for your heart health. It’s also associated with many other health conditions like obesity, insulin resistance, diabetes, depression, and inflammatory bowel disease. 

• BPC-157 has been extensively studied in animals for its gastroprotective effects, particularly in conditions characterized by gut inflammation and injury. This peptide promotes the repair and regeneration of damaged gastrointestinal tissues, enhances mucosal integrity of the stomach lining, and reduces inflammation within the gut. Moreover, BPC-157 may modulate gut microbiota composition, contributing to a healthy gut microbiome and improved digestive function.

Skin Burns:

• Skin burns pose significant challenges in wound healing and tissue regeneration. In animal studies, BPC-157 has shown remarkable efficacy in promoting the healing of skin burns by accelerating the formation of new skin tissue and reducing inflammation. It works by enhancing the migration and proliferation of skin cells, leading to faster wound closure and improved wound healing outcomes. Additionally, BPC-157 exhibits antioxidant properties, protecting skin cells from oxidative stress (when there are too many free radicals and not enough antioxidants). This helps cells survive and speeds up the healing process.

Corneal Injuries:

• The cornea (the clear covering over the front of the eye) is susceptible to injuries and infections that can impair vision. BPC-157 has emerged as a potential therapeutic agent for promoting corneal wound healing and reducing inflammation in the eye. Through its angiogenic and anti-inflammatory effects, BPC-157 accelerates the repair of corneal injuries, enhances epithelial cell proliferation, and promotes tissue regeneration. 

Brain Fog:

• Brain fog, characterized by thinking that feels cloudy or slow, can significantly impact daily functioning. BPC-157 exhibits neuroprotective effects and may help alleviate symptoms of brain fog by promoting neuronal survival and regeneration. Moreover, BPC-157 modulates neurotransmitter activity and reduces neuroinflammation, thereby enhancing cognitive function and mental clarity. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Today we are talking about Thymosin alpha-1 (TA1) and its potential benefits. All this and more in less than 2 minutes. 

Before we get into what TA1 is and does, we need to talk about the thymus gland. Your thymus gland is a small gland located in your upper chest behind your breastbone in the lymphatic system. It makes special white blood cells called T-cells. 

There are two types of T-cells: killer T cells and helper T cells. Both help your immune system fight disease and infection. Killer T cells destroy cancerous cells and cells infected with a virus. Helper T cells work with the other cells of the immune system to make an immune response.

What is Thymosin alpha 1 (TA1)?

TA1 is a peptide that's produced naturally by the thymus gland. As we age, our thymus gland shrinks (atrophies), and this affects the production of TA1. 

In our bodies, TA1 is known as a natural senolytic, which induces the death of aging cells our thymus makes. Taking TA1 as peptide therapy works by mimicking the body's natural release of TA1 in the thymus gland, which stimulates the production of T cells. It also decreases the production of certain proteins called cytokines that can cause chronic inflammatory or immune responses in some people (e.g., chronic fatigue syndrome and fibromyalgia).

Studies have shown that people fighting infection have a lower amount of circulating TA1 than healthy people.

What are the BENEFITS? 

TA1 is used for clinical conditions where immune support is needed. Zadaxin is a TA1 peptide evaluated and approved in 30 countries for treating hepatitis B & C, HIV, and AIDS. It's also used along with chemotherapy for certain lung, liver, and skin cancer patients. In addition, it is used in people with DiGeorge syndrome. Currently, the medication is in Phase III trials for the treatment of hepatitis C and Phase II trials for hepatitis B in the United States. 

Fun fact: TA1 has an Orphan Drug approval by the FDA for several indications. Orphan drugs are medications approved by the FDA for rare conditions that affect fewer than 200,000 people in the U.S.

TA1 has also shown promising results in the treatment of Lyme disease. 

How do I take TA1?

Compared to other peptide therapies, TA1 has a longer half-life of 2 hours, requiring fewer peptide injections. The peptide injection is a subcutaneous injection (injected into the fatty tissue) once every third day. For viral infections, treatments usually last for 2 weeks. But, depending on what you're treating and how serious your infection is, treatment could last 3 months or more.

Possible side effects include redness, itching, or swelling at the injection site. Rare cases of increases in liver enzymes have happened. If you have signs of liver injury (nausea or vomiting, yellowing of the skin or eyes (jaundice), or stomach pain tell your healthcare provider right away. As always, you should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together in one easy place.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. And subscribe to our podcast. Have a happy, healthy week!

Pro Tips

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. They also help with anti-aging. Our favorite collagen peptide powder is Thorne® Collagen Plus. 

Do you ever wonder how synthetic peptides are made?

The process of making peptides, commonly known as peptide synthesis, is a sophisticated chemical process that allows scientists to create specific sequences of amino acids. In this podcast, we will explore the fascinating world of peptide synthesis, shedding light on the methods and techniques used to produce these amazing compounds.

Understanding Peptides:

Peptides are short chains of amino acids, the fundamental units that make up proteins. The unique sequence of amino acids in a peptide determines its specific function and biological activity. Synthesizing peptides involves creating these sequences in a controlled and precise manner to mimic naturally occurring peptides or design novel ones for specific purposes, such as therapeutic drugs, vaccines, or research tools.

What are the methods of Peptide Synthesis?

Solid-Phase Peptide Synthesis (SPPS):

The most widely used method for peptide synthesis is solid-phase peptide synthesis. This technique, developed by Nobel laureate Bruce Merrifield in the 1960s, involves attaching the C-terminal amino acid to an insoluble resin support. The amino acids are then sequentially added to the growing peptide chain while attached to the solid support. After synthesis, the peptide is cleaved from the resin and purified.

Liquid-Phase Peptide Synthesis:

Liquid-phase peptide synthesis is an older method that involves performing the entire synthesis in solution without using a solid support. While less commonly used today, it is still used for specific applications and for synthesizing shorter peptide sequences.

Chemical Synthesis:

Chemical synthesis involves coupling individual amino acids together in a stepwise manner. While this method is more labor-intensive and time-consuming, it is suitable for producing small peptides or those with complex structures that may be difficult to make in solid-phase synthesis.

Recombinant DNA Technology:

In the realm of biotechnology, peptides can also be produced using recombinant DNA technology. This method involves introducing a gene encoding the desired peptide into a host organism, such as bacteria or yeast. The host organism then produces the peptide through its own cellular machinery.

Some examples of peptides that have been synthesized using SPPS:

Insulin:

Probably the most widely recognized peptide is insulin. Insulin is responsible for regulating blood sugar levels, has been synthesized using solid-phase peptide synthesis to help treat diabetes.

Oxytocin:

Oxytocin is a neuropeptide that plays a crucial role in social bonding and sex drive. 

Melanotan II:

Melanotan II, a synthetic peptide that stimulates melanin production in the skin, has been synthesized using solid-phase peptide synthesis. It is sometimes used for tanning purposes and sexual health.

GLP-1 Agonists like semaglutide:

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type 2 diabetes and obesity. It is a synthetic peptide designed to mimic the action of endogenous GLP-1, which plays a role in blood sugar regulation and appetite suppression. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Back pain is a common health condition affecting millions of people worldwide, decreasing their quality of life and productivity. Traditional treatments often provide temporary relief, prompting the search for innovative therapies. Peptide therapies have shown promising results in addressing back pain. 

In this podcast, we'll talk about the common causes of back pain, traditional treatments used to treat back pain, and peptide therapies used for back pain management.

What causes back pain?

If you’ve had lower back pain, you know how debilitating it can be (e.g., affecting your quality of life and making it hard to work, exercise, or partake in extracurricular activities). Often, the exact cause of pain isn’t understood, but most cases of low back pain come on suddenly and go away within one month. Typically, the pain comes from the spine or the ligaments and muscles around the spine. This is common in those with muscle strains or sprains of the muscles or ligaments around the spine from mild trauma or repetitive physical activity. 

People who have serious medical conditions can also experience back pain. A few common causes could be arthritis of the spine (spondylosis), herniated disc (bulging disc), spinal stenosis (when the space around the spinal cord narrows, causing pain, numbness, or tingling in the legs.

How can I make my back pain stop?

If your back is bothering you, there are some treatments that you can try at home to help lessen the pain.

Non-strenuous activity:  Although you’re in pain and you may want to stay in bed when you have back pain, it’s important to know that this can make the pain worse. It helps to try activities like walking and gentle stretching.

Over-the-counter (OTC) medications: You might be able to help relieve acute back pain with OTC anti-inflammatory medications like naproxen or ibuprofen. These medications block the body’s production of prostaglandins (natural chemicals) that trigger pain, swelling, and inflammation.

Heat or ice: It’s hard to know when to use heat vs. ice for back pain. The rule of thumb is to start with ice when your back hurts after a minor injury. You can use ice packs, cold towels, and ice baths. You can try this for 2 days and then move to heat. Heat helps with pain by increasing blood flow to help relax your muscles and help the body to repair injured tissue. Heat will not only help with pain but can also help with stiffness to loosen up your back muscles. This, in turn, helps with your mobility to get you back to living a normal life. For heat, you can apply hot water bottles to the area of pain. You can also use hot towels, heating pads, and saunas. 

If you have back pain that lasts more than one month or occurs with symptoms like severe numbness or weakness in the legs, inability to urinate, or numbness in the groin, talk to a healthcare provider. Never try to treat back pain at home if your pain is caused by a major trauma or injury (e.g., car accident or fall) or a previous spinal procedure (e.g., surgery or injections).

Peptides for back pain

BPC-157- BPC 157, or Body Protection Compound 157, is a peptide derived from stomach acid. It works by decreasing inflammation and increasing blood flow to damaged tissues. It speeds up the healing of wounds, tendons, ligaments, bone injuries, your nervous system, and even the digestive tract. 

LL-37- LL-37, a naturally occurring antimicrobial peptide, exhibits potent anti-inflammatory properties. Chronic back pain often results from inflammation of spinal nerves and surrounding tissues. LL-37 mitigates inflammation, providing relief to patients suffering from conditions like sciatica and herniated discs. By modulating the immune response, LL-37 promotes healing and reduces pain.

Thymosin Beta-4 (TB4)-  Thymosin Beta-4 is a peptide used for cellular regeneration. It plays a pivotal role in tissue repair and wound healing. In the context of back pain, TB4 aids in regenerating damaged spinal discs and muscles, offering long-term relief.  It works by binding actin (proteins that make up 10% of the total proteins in cells). Actin helps with cell division, signaling, and shape. It also speeds up the rate of new tissue growth and new blood vessel formation. TB4 also helps wounds heal.

Melanocortin Peptides- Melanocortin peptides, including Melanotan II, have shown promise in managing chronic pain conditions. These peptides work by modulating the body's pain perception pathways, providing relief to individuals suffering from persistent back pain. By interacting with melanocortin receptors, these peptides alter neurotransmitter levels, effectively reducing pain signals transmitted to the brain.

Substance P Inhibitors- Substance P is a neurotransmitter associated with pain perception. Peptide therapies targeting Substance P receptors can effectively alleviate back pain by inhibiting nerve sensitivity. By blocking these receptors, these peptides reduce the transmission of pain signals, offering relief to patients with conditions like neuropathic back pain.

Peptide therapies represent a groundbreaking approach to back pain management, offering hope to individuals whose lives are hindered by chronic discomfort. As research in this field continues to advance, peptide therapies are set to revolutionize the way we treat back pain, providing a brighter future for millions who suffer from back pain. 

Note: Always consult with a healthcare professional before undergoing any peptide therapy to ensure safe and effective treatment.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It’s vegan, paleo, and keto-friendly.

Today we are talking about BPC 157, what it’s for, and its potential benefits. All this and more in less than 2 minutes. 

What is BPC 157? 

BPC 157 or “Body Protection Compound 157” is a lab-made peptide that is a partial copy of human BPC found in stomach acid (gastric juice). 

BPC works by speeding up the rate of the formation of new blood vessels (aka angiogenesis) to help wounds heal. It’s often prescribed to help repair damage caused by inflammation and help improve joint, muscle, ligament, tendon, and bone health.

What are its benefits?

BPC 157 is useful to those looking to help with tendon and ligament healing by increasing the growth of fibroblasts (a type of cells found in connective tissues like bone and cartilage that are involved in making collagen to provide strength to the site of a wound).

It can also help heal stomach ulcers caused by NSAIDs (non-steroidal anti-inflammatory) medications like ibuprofen and naproxen as well as help repair damaged intestinal tissues caused by inflammatory bowel disease. 

How do you use this?

For general use, BPC 157 can be taken either orally or inject the peptides under the skin (subcutaneously) once daily. If injury-specific, dosing is SPLIT into TWICE DAILY injections under the skin specifically around the injury site.

Possible side effects include redness, itching, or swelling at the injection site. You should tell your healthcare provider about any side effects you experience. 

You can find more information at pepties.com.  That’s peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast please share it with your friends and family on social media and have a happy, healthy week!

In the intricate dance of human reproduction, a peptide called Kisspeptin plays an important role in guiding the timing of ovulation in women and the production of sperm in men. Its discovery has sparked a wave of excitement in the field of reproductive medicine, offering new insights and potential treatments for those facing fertility challenges. 

In this podcast, we’ll talk about how kisspeptin works for fertility issues and much more.

What is Kisspeptin?

Kisspeptin is a neuropeptide that plays a vital role in reproduction, sexual behavior, and attraction. It enhances brain activity linked with sexual arousal and attraction while also prompting the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This, in turn, triggers the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are crucial for testosterone and estradiol production.

The controlled stimulation of LH and FSH by Kisspeptin offers a potential advantage over mainstay fertility treatments. This is because it may reduce the risk of ovarian overstimulation often associated with hormonal injections. Because of this, Kisspeptin is currently being studied as a promising alternative to current fertility treatment protocols.

Moreover, Kisspeptin’s ability to elevate LH and FSH levels may hold promise for men undergoing testosterone replacement therapy (TRT) programs. In cases where exogenous testosterone has led to decreased LH or FSH levels, Kisspeptin could offer a solution to restore hormonal balance.

How Does Kisspeptin Work for Fertility Issues?

Kisspeptin exerts its effects on fertility primarily through the hypothalamic-pituitary-gonadal (HPG) axis, a complex network of interactions between the brain and reproductive organs. In women, kisspeptin stimulates the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which then triggers the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. These hormones, in turn, regulate the menstrual cycle and ovulation.

In men, kisspeptin plays a similar role in stimulating GnRH release, which then prompts the production of LH and FSH, essential for spermatogenesis and testosterone production. Thus, kisspeptin is crucial for both female and male fertility.

Utilizing Kisspeptin in Fertility Treatments:

For individuals experiencing fertility issues, especially those related to irregular menstrual cycles or anovulation (lack of ovulation), kisspeptin has emerged as a promising therapeutic option. In clinical settings, synthetic forms of kisspeptin are administered via injection to stimulate the HPG axis and induce ovulation in women or improve sperm production in men.

Common Kisspeptin Side Effects:

While kisspeptin therapy is generally well-tolerated, like any medication, it can cause side effects. Common side effects may include:

1. Injection site reactions: Pain, swelling, or redness at the injection site.

2. Nausea or vomiting: Some individuals may experience gastrointestinal symptoms following kisspeptin administration.

3. Headaches: Mild to moderate headaches have been reported in some cases.

4. Hot flashes: Temporary episodes of feeling flushed or overheated may occur.

It's important to note that the occurrence and severity of side effects can vary among individuals, and not everyone will experience them.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

We’ve decided to do a mini-series on peptides and sexual wellness. Over the next few weeks, we'll cover peptide therapies used to help women and men with low sex drive. As well as a peptide that helps with increased arousal and may help with infertility.

Today, we'll focus on PT-141 (bremelanotide), what it is, how it works for low sex drive, and potential side effects to watch out for.

What is PT-141 (bremelanotide)?

Bremelanotide is a melanocortin receptor agonist peptide. Melanocortin is a natural hormone in your body that works on receptors in your brain and nervous system to cause sexual arousal and influence sexual behavior. However, we don’t know exactly how it works to improve sex drive. It can also work on receptors in cells that produce skin color (melanocytes).

You may know bremelanotide as Vyleesi. This medication was originally FDA-approved in 2019 to help low sex drive in women who haven’t gone through menopause yet. While it’s not approved for low sex drive in men, some may use it off-label. 

In these cases, bremelanotide is also used in men to help improve erections, libido, sex drive, and performance.

How is PT-141 (bremelanotide) dosed and given?

PT-141 (bremelanotide) is given on an as-needed basis at least 45 minutes before sex as an injection under the skin (subcutaneously). You can give the injection with or without food into your abdomen, upper arm, or thigh. You should avoid injecting into the same spot every time. But you can inject into the same body area (e.g., abdomen) as long as you rotate your injection site. 

The dose of PT-141 is 1.75 mg 45 minutes before sex for women and 1 mg for men (for erections and sex drive). You shouldn’t take more than one dose in a day or use more than 8 doses per month.

What are the potential side effects of PT-141 (bremelanotide)?

You may experience some unwanted side effects that may get better over time as your body gets used to the peptide. These include the following:

• nausea (40%) (lasts approximately 2 hours, but improved for most people with the second dose)
• flushing of the skin
• injection site reactions like pain, redness, itching, or bruising
• headache
• vomiting

In some cases, PT-141 (bremelanotide) can cause more serious side effects. Although rare, this peptide can temporarily raise your blood pressure and lower your heart rate after each dose. Your blood pressure and heart rate should go back to normal within 12 hours after taking this medication, but because of this side effect, you shouldn't take this medication if you have heart disease. 

Because PT-141 (bremelanotide) can work on receptors in cells that produce skin color, the peptide can cause the color of your skin to darken. Areas of the skin, such as the face, gums, and breasts, are more likely to become discolored.

People who take PT-141 every day or have naturally dark skin are more likely to have a darkening of the skin. It’s not known if your skin will return back to normal after you stop taking PT-141. This is why it’s not recommended to take more than 8 doses per month. 

Who should not use PT-141 (bremelanotide)?

Because this peptide can temporarily raise your blood pressure or lower your heart rate after each dose, you shouldn’t use PT-141 if you have high blood pressure that is not controlled or a known heart disease.

It’s not known if PT-141 will harm your unborn baby. If you are pregnant or plan to become pregnant, you shouldn’t take PT-141.

Can PT-141 interact with other medications?

PT-141 may slow down how quickly food leaves your stomach, and this may also affect how certain oral medications are absorbed by your body when taken with PT-141. You'll want to avoid using PT-141 when taking oral medications that are dependent on certain concentrations for efficacy, like antibiotics or pain relief medications like indomethacin. 

Always tell your healthcare provider or pharmacist about all the medicines you take, including over-the-counter medicines. PT-141 may affect the way other medicines may work and vice versa.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

They work to kill bacteria (bactericidal) by preventing them from making their own protective coating in your body.

Polycystic Ovary Syndrome (PCOS) affects millions of women worldwide, leading to distressing symptoms and potential health complications. While various treatment options have been explored, a recent breakthrough has emerged in GLP-1 agonists, offering new hope and possibilities for managing this complex condition. In this podcast, we'll talk about what PCOS is, common symptoms of PCOS, current treatments available for PCOS, including lifestyle changes and medications, and the role of GLP-1 agonists in this condition.

What is PCOS?

PCOS is a hormonal imbalance that affects people with ovaries. It affects different parts of the body, including the reproductive system, metabolism, and the skin. People with PCOS usually have high levels of "male hormones", specifically androgens. Some examples of androgens are testosterone, DHEAS, and DHT. People with PCOS also have high levels of insulin. When there are high levels of insulin, it can cause insulin resistance. In this situation, the cells in the body ignore insulin. When this happens, blood sugar levels are high, which can lead to prediabetes and type 2 diabetes. 

People with PCOS may also have irregular periods. This is also due to high levels of androgens in the body. Unfortunately, because of this, PCOS is one of the most common causes of infertility. It's also associated with sleep apnea, obesity, acne, high blood pressure, and high cholesterol. It can also increase the risk of depression and anxiety. 

What are the symptoms of PCOS? 

Some people may have one or two symptoms. Common symptoms include irregular periods (e.g., no period, missed period, or very heavy periods) and cysts on one or both ovaries. Others may experience fertility problems and obesity. At the same time, others can experience skin problems such as increased hair growth on the face, chest, stomach, and upper thighs (hirsutism), acne or oily skin, or patches of thick, dark skin on the neck, armpits, or genitals (acanthosis).

What are common PCOS treatments?

Lifestyle changes should focus on nutrition (healthy balanced diet) and exercise. This is because weight loss can lower your androgen levels, improving PCOS symptoms and lowering your risk of heart disease and diabetes. Weight loss can also help regulate your menstrual cycle, increasing ovulation and pregnancy rates.

Medication options for PCOS include hormonal birth control to help regulate periods and improve acne. It may also include medications that lower or block androgen levels, such as spironolactone, flutamide, and finasteride. These medications help with acne and excess hair growth. 

Metformin should be used for women and adolescent girls with PCOS and type 2 diabetes. Metformin helps lower blood sugar levels to help insulin resistance due to PCOS. It may also help with irregular periods. 

Some people may require medications that help with fertility. Some examples include clomiphene and letrozole. These medications help stimulate ovulation, which increases your chance of getting pregnant. 

The role of GLP-1 agonists for PCOS

GLP-1 (Glucagon-Like Peptide-1) agonists like semaglutide are a class of medications primarily used to manage diabetes. However, recent research has uncovered their potential in treating PCOS. GLP-1 is a hormone that stimulates insulin secretion and inhibits glucagon production, helping to regulate blood sugar levels. In the context of PCOS, these agonists offer several benefits:

1. Managing Insulin Resistance: Insulin resistance is a common feature of PCOS, leading to elevated insulin levels in the bloodstream. GLP-1 agonists enhance insulin sensitivity, assisting the body in utilizing insulin effectively. Doing so helps regulate blood sugar levels and reduce the risk of type 2 diabetes in women with PCOS.

2. Weight Management: Many women with PCOS struggle with obesity, exacerbating the syndrome's symptoms. GLP-1 agonists can promote weight loss by increasing feelings of fullness, reducing appetite, and slowing down gastric emptying. This weight loss can lead to improved hormonal balance and reduced severity of PCOS symptoms.

3. Restoring Menstrual Regularity: One of the hallmark signs of PCOS is irregular menstrual cycles. GLP-1 agonists have been found to restore menstrual regularity by addressing the underlying insulin resistance and hormonal imbalances. This regularity is important for improving fertility and overall reproductive health.

4. Reducing Androgen Levels: Elevated levels of androgens in women with PCOS contribute to symptoms like acne and excessive hair growth. GLP-1 agonists help lower androgen levels, alleviating these distressing symptoms and improving the quality of life for individuals affected by PCOS.

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily greens in your routine to help with gut, skin, nail, bone, and joint health. We take AG1 (athletic greens) every day. Not only does it have vitamins, minerals, and a diverse range of whole-food sourced ingredients, but it also has probiotics to promote a healthy gut microbiome and adaptogens to help with focus and mood balance. It's vegan, paleo, and keto-friendly.

Someone might switch from semaglutide to tirzepatide to achieve greater weight loss or improve blood sugar control. Tirzepatide has been shown to be more effective for some people because it works on two different hormones, GLP-1 and GIP. This combination can lead to better results in managing weight and overall health. 

Additionally, if a person stops losing weight on semaglutide or isn't feeling as much appetite suppression, switching to tirzepatide could provide a new option, especially at higher doses.

In this podcast, we’ll discuss the feedback from doctors and patients about switching from semaglutide to tirzepatide for weight loss. The experiences shared are quite varied. Here are some common themes based on what healthcare providers and patients reported.

1. Appetite Suppression

• Patients' Experiences:

• Some patients report weaker appetite suppression with tirzepatide compared to semaglutide. They mention that they felt more consistently full or experienced less "food noise" (persistent thoughts about food) with semaglutide.

• Others find tirzepatide equally or more effective at reducing hunger, especially at higher doses (10 mg to 15 mg). They note that their appetite was well-controlled after titrating to these higher doses.

• Clinicians' Observations:

• Many clinicians observe that tirzepatide’s appetite suppression is dose-dependent, with lower doses (5 mg) sometimes being less effective than semaglutide 2.4 mg, but higher doses (7.5 mg and up) providing stronger suppression.

• Some clinics report that patients may need more time on tirzepatide for the full appetite-suppressing effects to become noticeable.

2. Weight Loss:

• Patients' Experiences:

• Many patients experience greater or more rapid weight loss with tirzepatide, especially when titrated to higher doses (10 mg or more). Some report that they plateaued with semaglutide but started losing more weight after switching to tirzepatide.

• Others find that their weight loss slows down after switching to tirzepatide, particularly if their tirzepatide dose starts low (e.g., 2.5 or 5 mg), which may take time to match the effects of semaglutide 2.4 mg.

• Clinicians' Observations:

• Physicians often report that tirzepatide tends to lead to greater weight loss overall compared to semaglutide, especially when patients reach the higher doses (15 mg).

• However, individual variability plays a significant role, with some patients responding better to one medication over the other, depending on their metabolic profile and personal response to the medications.

3. Side Effects:

• Patients' Experiences:

• Patients commonly note that tirzepatide's side effects are similar to semaglutide, particularly stomach-related symptoms like nausea, vomiting, and diarrhea. However, these effects tend to lessen over time with both medications.

• On the other hand, some patients may experience more intense side effects with tirzepatide, especially during the titration phase.

• Clinicians' Observations:

• Clinics generally find that tirzepatide’s tolerability improves when the dose is titrated slowly, starting at 2.5 mg. Jumping directly to higher doses (5 mg or more) can increase the likelihood of nausea and other stomach-related side effects.

• Long-term side effect profiles are comparable between the two, but some clinics observe that tirzepatide's dual mechanism (GIP + GLP-1) might cause more initial stomach discomfort in certain patients.

4. Patient Preferences:

• Some patients prefer staying on semaglutide because it effectively curbs their hunger and controls cravings better, even if tirzepatide provides more weight loss.

• Others favor tirzepatide due to its better results in weight loss and overall improvements in metabolic health, especially once they reach higher doses.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

Today we will talk about natural supplements used for joint pain and the science behind some of the claims on the labels. But it's important to remember that just because something is labeled as "natural" doesn't always mean it's better or safer for you.

Problems with your joints can happen at any age. But when we get older, our joints become stiffer and less flexible. The fluid in our joints may also decrease, and the cartilage may begin to rub together and eventually wear away. These changes may lead to injuries or conditions like osteoarthritis, rheumatoid arthritis (RA), gout, and psoriatic arthritis (PsA). 

When our joints break down, it may cause inflammation in the joint space and cause stiffness and pain. Not only can joint stiffness and pain cause physical limitations that may interfere with your work or personal life, but it can start to affect your mood and cause some people extreme stress.

What supplements can help with joint pain?

Clinical studies show that turmeric (curcumin), hydrolyzed collagen, L-carnitine (an amino acid), passion fruit peel extract, and Indian frankincense (Boswellia Phytosome) may help improve osteoarthritis in the short term.

Omega-3 fatty acids may help people with osteoarthritis or those with inflammatory arthritis (gout, RA, PsA). But it's important to know that these supplements only help with symptom relief. They don't cure or reverse any damage that the condition has caused.

CBD oil (Hemp Oil) has also become increasingly popular over the past few years with claims that it can help with chronic pain. Some studies have shown promising results, but more research on humans is needed. And there are no universal guidelines on how much CBD oil you should use for chronic pain. 

When it comes to CBD oil, make sure to look for products that are lab tested by third parties. Make sure the label has the amount of cannabinoids listed along with a complete list of ingredients, instructions, storage information, lot number, and expiration date. You'll want to avoid CBD products that don't have the company or contact name listed.  

Is there anything else besides supplements for joint pain?

So you've tried everything to help your joint pain. You've tried several different supplements. You've tried to incorporate anti-inflammatory foods into your diet (e.g., berries, fatty fish, and leafy green vegetables) to help fight inflammation in your joints. And you drink plenty of water throughout the day to help make the synovial fluid in your joints.

You even get regular exercise to maintain a healthy weight and to help keep your joints lubricated and stretch before and after each workout to help avoid unnecessary injuries.

No matter what you've tried, you continue to have joint pain and stiffness. This is where BPC 157 may help. 

BPC 157, or Body Protection Compound 157, is a peptide derived from stomach acid. It works by decreasing inflammation and increasing blood flow to damaged tissues. As a result, it speeds up the healing of wounds, tendons, ligaments, bone injuries, your nervous system, and even the digestive tract. 

How do you use BPC 157?

For general use, BPC 157 can be taken either orally or injected under the skin (subcutaneously) once daily. If injury-specific, dosing is SPLIT into TWICE DAILY injections under the skin, specifically around the injury site.

Possible side effects include redness, itching, or swelling at the injection site. You should tell your healthcare provider about any side effects you experience. 

Thanks again for listening to The Peptide Podcast, we love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Helicobacter pylori (H. pylori) bacteria can infect the stomach lining and digestive tract, leading to gastrointestinal (GI) conditions such as gastritis (inflammation of the stomach lining) and stomach and intestinal ulcers. 

Interestingly enough, most people who have H.pylori don't have any symptoms. But when H.pylori causes inflammation of the stomach or ulcers, symptoms such as burning or dull pain in the upper abdomen can occur. You may also experience worse pain on an empty stomach, nausea, bloating, and burping. If ulcers start to bleed, it can lead to blood in the stool or vomit, low blood cell counts, and fatigue.

Conventional H.pylori antibiotic treatments typically consist of two to three antibiotics like clarithromycin, amoxicillin, and metronidazole that are used together with a proton pump inhibitor like omeprazole. Your doctor may also want you to take Pepto-Bismol. However, there is ongoing research on alternative approaches, including peptide therapies.  

Today, we’ll talk about these peptide therapies and how they may work against H.pylori.

It's important to note that the efficacy and safety of these therapies may vary, and they should only be considered under the guidance of healthcare professionals. 

Some peptides that have been studied for their potential effects against H. pylori:

Antimicrobial Peptides (AMPs): AMPs are small peptides with antimicrobial properties. Some AMPs have demonstrated activity against H. pylori in laboratory studies. They may work by disrupting the bacterial cell membrane or interfering with essential bacterial functions.

• LL-37 (L-L- three-seven): LL-37 has both antimicrobial and immunomodulatory effects by influencing the host's immune response.

• Bovine Lactoferrin: Lactoferrin is a multifunctional protein found in milk and other bodily fluids. Peptides derived from lactoferrin have been studied for both their immunomodulatory and antibacterial properties, including their potential to modulate the immune response against H. pylori.

• α-Defensins: α-Defensins are a family of antimicrobial peptides found in the innate immune system (skin and the lining of your digestive and respiratory systems). These work against H. pylori by disrupting the bacterial cell membrane.

• Hepcidin (Hep-suh-dn): While its primary role is in iron regulation, hepcidin has been investigated for antimicrobial effects against various bacteria, including H. pylori.

• Histatin (hǏ-statin): Histatins are found in human saliva. Some studies have suggested that certain histatins may have inhibitory effects on H. pylori, contributing to the antimicrobial activity of saliva.

Immunomodulatory Peptides: Peptides that modulate the immune system could help manage H. pylori infection. These peptides may enhance the host immune response, facilitating the clearance of the bacteria.

• β-Defensins: β-Defensins modulate the immune response against H. pylori and contribute to the host's defense mechanisms.

• Thymosin Alpha-1 (TA-1): This peptide contributes to immune modulation in the context of H. pylori infection.

Probiotic-Derived Peptides: Some peptides derived from probiotic bacteria have been explored for their potential to inhibit the growth of H. pylori. Probiotics are “good bacteria" that may make the stomach and GI tract less hospitable to H.pylori. Some examples include:

• Lactobacillus reuteri (ro-tir-ree)

• Lactobacillus acidophilus

• Bifodobacterium bifidum

• Streptococcus thermophilus (therm-oph-i-lus)

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Insulin resistance isn’t just about what we eat. It’s about how our bodies respond to food, how we store fat, and how our hormones work together to keep everything in balance. And did you know that insulin resistance can look different depending on whether you’re a man or a woman?

In this episode, we’ll break down the unique symptoms of insulin resistance in both men and women, from weight gain and fatigue to hormonal disruptions and more. Whether you’re concerned about your own health or just curious about this metabolic condition, this episode will help you understand how insulin resistance manifests differently in each gender and why it’s so important to recognize early symptoms.

What is insulin resistance?

Insulin resistance occurs when the body's cells become less responsive to insulin, leading to higher blood sugar levels. While both men and women can experience similar underlying metabolic changes, insulin resistance symptoms may manifest differently in each gender due to hormonal and physiological differences.

Insulin Resistance Symptoms in Women:

1. Weight Gain (Especially Around the Abdomen and Hips)
   Women may notice weight gain around the abdomen, hips, and thighs. The hormonal fluctuations in women, particularly with estrogen and insulin, may cause fat to accumulate more readily in these areas.

2. Polycystic Ovary Syndrome (PCOS)
   Insulin resistance is a key factor in PCOS, a condition that is characterized by irregular periods, excessive hair growth (hirsutism), acne, and ovarian cysts. Insulin resistance can exacerbate the symptoms of PCOS.

3. Irregular Menstrual Cycles
   Elevated insulin levels can interfere with hormonal regulation, causing irregular or absent menstrual cycles. This is often seen in women with PCOS or those who are insulin-resistant.

4. Fatigue and Energy Slumps
   Women with insulin resistance may feel more fatigued or experience energy dips throughout the day as the body struggles to process glucose for energy efficiently.

5. Increased Hunger and Cravings (Particularly for Carbs)
   Insulin resistance can lead to constant hunger or cravings for sugary, high-carb foods, as the body's ability to process and utilize glucose effectively is impaired.

6. Skin Changes
   Conditions like Acanthosis Nigricans, which results in dark, thickened skin around the neck, armpits, or groin, are more common in women with insulin resistance. Women may also experience skin tags, especially around the neck or underarms.

7. Mood Swings and Depression
   Insulin resistance can impact the balance of neurotransmitters in the brain, leading to mood swings, irritability, and even contributing to symptoms of depression or anxiety in some women.

8. Increased Risk of Gestational Diabetes
   Women who develop gestational diabetes during pregnancy are at a higher risk of developing type 2 diabetes and insulin resistance later in life.

Insulin Resistance Symptoms in Men:

1. Abdominal Fat (Visceral Fat)
   Men are more likely to store fat in the abdominal area, known as visceral fat. This type of fat is linked to an increased risk of insulin resistance and metabolic syndrome. It can contribute to a larger waist circumference and an “apple-shaped” body.

2. Low Energy and Fatigue
   Men with insulin resistance may experience chronic fatigue and decreased energy levels, as their bodies are less effective at converting glucose into usable energy.

3. Reduced Muscle Mass
   Insulin resistance may lead to reduced muscle mass, as insulin is also a hormone involved in muscle repair and growth. Men might notice a decrease in strength or difficulty gaining muscle despite exercise.

4. Increased Hunger and Cravings
   Like women, men with insulin resistance may also experience increased hunger, particularly for high-carb and sugary foods. This can lead to overeating or difficulty maintaining a healthy weight.

5. Erectile Dysfunction
   Insulin resistance can impair blood flow and affect hormone levels, leading to erectile dysfunction (ED). This is a common issue for men with insulin resistance or metabolic syndrome.

6. High Blood Pressure
   Insulin resistance is often associated with hypertension (high blood pressure), which is a risk factor for heart disease. This may be one of the early signs of insulin resistance in men.

7. Fatty Liver Disease
   Non-alcoholic fatty liver disease (NAFLD) is a condition in which fat builds up in the liver and is closely associated with insulin resistance. It is more common in men and can lead to liver inflammation or more serious liver conditions if left unchecked.

8. Sleep Apnea
   Men with insulin resistance may be at higher risk for sleep apnea, a condition characterized by interrupted breathing during sleep, which can worsen metabolic problems and further disrupt insulin sensitivity.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

If you’re ready to dive deeper into the world of nutrition, don’t miss my new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. The best part? If you have Kindle Unlimited, it’s always free! So grab your copy today and start your journey to a healthier, smarter way of eating!

Thank you for your support of the Peptide Podcast. If you’re ready to dive deeper into the world of nutrition, don’t miss Dr. Nikki’s new ebook, Eat Smart: Powerful Tips for a Healthier You, now available on Amazon! It’s packed with easy-to-understand, science-backed tips to help you optimize your diet, boost metabolism, and reduce inflammation. You will find the link in the podcast description…now on to the podcast…

Today we're going to talk about a question I get often. How do I know if I need weight-loss medication? 

Unfortunately, the answer isn't simple, and many factors must be considered. The first step is to talk with your primary care physician to rule out certain health conditions (e.g., hypothyroidism, Cushing's disease, and PCOS) or medications (e.g., steroids, antidepressants, and beta blockers) that can contribute to excess weight. It's a good idea to rule out these possibilities before starting a weight-loss medication.

Then your provider can help you set realistic weight goals and help you make changes to your diet. You can also get help increasing your physical activity and monitoring for any weight-related health risks (e.g., high blood pressure, joint pain, and type 2 diabetes). 

When these lifestyle changes (diet and exercise) aren't enough for you to lose the weight you desire, weight-loss medications like semaglutide may be helpful.

It's important to remember that obesity is a chronic, complicated medical condition. And it's difficult to manage. When a person has excess body fat, they're at risk for many health problems like high blood pressure, type 2 diabetes, stroke, heart disease, high cholesterol, depression, anxiety, fertility issues, joint and muscle pains, sleep and energy problems, erectile dysfunction, and several types of cancer. 

The fact of the matter is people with obesity die younger than people who do not have obesity. 

It's also important to keep in mind that even when taking weight-loss medications like semaglutide, you must continue to eat healthy and exercise regularly to maintain long-term weight loss. 

What causes obesity (weight gain)?

When it comes to weight gain, most people know that obesity can be caused by eating too many calories and not exercising enough. But the fact is that a complex interaction of our genes and hormones with our environments causes obesity.

Scientists have been studying how our genes and hormones affect our weight for years. Researchers have studied leptin levels, POMC gene mutations, testosterone and estrogen levels, and cortisol levels.

Also, lack of sleep, stress, and an unhealthy gut microbiome can lead to weight gain. 

Too little sleep leads to higher levels of ghrelin (a gut hormone that stimulates appetite) and lower levels of leptin (a hormone released by your fat cells that suppress your appetite). 

When we're stressed, our bodies release cortisol (the stress hormone). Short-term, this hormone helps to increase our heart rate, blood pressure, and blood sugar. But, with repeated stress, over time, you begin to feel tired, and depressed and experience weight gain.

An unhealthy gut microbiome can affect how you store fats and absorb nutrients from your food, making it harder to maintain a healthy weight. Like lack of sleep, an unhealthy gut may also increase the amount of ghrelin, causing you to feel hungry, which may lead to weight gain.

How can I improve my sleep, stress levels, and gut health?

Last week I briefly talked about ways to improve your sleep environment by avoiding technology, caffeine, and alcohol before bed. Other tips to improve sleep are to use your bedroom for sleep and intimate activities only (avoid watching television, reading books, and working on your computer), have a consistent bedtime and wake time, and keep your bedroom dark and at a comfortable temperature. 

Stress can come from all types of life events (e.g., work, death of a friend or family member, divorce, childbirth). What is stressful for one person may not be stressful for someone else. Depending on our current situation, certain things can make us more sensitive to life's stresses (e.g., financial situation, health situation, support system at home). But one thing is certain: decreasing stress can help reduce the effects that stress can have on our minds and bodies. Engaging in regular physical activity, if able, practicing meditation, spending time with friends or family, getting quality sleep, talking to a therapist, and eating healthy food can help relieve the effect of stress.

I've talked about gut health in the context of BPC 157. But as a refresher, you can improve your gut microbiome by eating a diverse range of foods, particularly high-fiber foods like broccoli and lentils and foods rich in polyphenols (e.g., whole grains and dark chocolate). You also should limit your intake of artificial sweeteners and take antibiotics only when necessary. You may also want to consider talking to your healthcare provider about taking a daily probiotic to help reduce gut inflammation and encourage "good" bacteria to grow if you continue to have stomach pain, cramping, gas, or bloating.

Thanks again for listening to The Peptide Podcast. You can find more information at pepties.com. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Glucagon-like peptide-1 (GLP-1) is a hormone in the intestine that regulates blood sugar levels, appetite, and digestion. Increasing GLP-1 levels can be beneficial for people with diabetes, obesity, or metabolic syndrome. 

While medications like semaglutide and tirzepatide exist to stimulate GLP-1 production, incorporating certain foods and supplements into your diet can also naturally enhance GLP-1 secretion. In this podcast, we’ll talk about some of these foods and supplements and their potential benefits for gut health and metabolism.

Soluble Fiber-Rich Foods

Fiber is well-known for its numerous health benefits, including improved digestion, weight management, and blood sugar control. Certain types of fiber, such as soluble fiber, have been shown to increase GLP-1 secretion. 

Oats, barley, and legumes (such as beans, lentils, and chickpeas) are rich in soluble fiber. Brussels sprouts, avocados, and flaxseeds also help. Incorporating these soluble fiber-rich foods into your meals can help support healthy GLP-1 levels and promote overall gut health.

Remember that soluble fiber absorbs water and creates a gel-like substance in your body. Because of this, staying hydrated and gradually increasing your fiber intake over time is important to help minimize digestive upset and constipation.

Fatty Fish

Fatty fish like salmon, mackerel, sardines, and trout are excellent sources of omega-3 fatty acids, which have been shown to have numerous health benefits, including improving insulin sensitivity and increasing GLP-1 secretion. 

Incorporating fatty fish into your diet two to three times per week can help support a healthy gut and metabolic function. Grilling, baking, or broiling fish with herbs and spices is a delicious and nutritious way to enjoy these omega-3-rich foods.

Nuts and Seeds

Nuts and seeds are nutrient-dense foods with various health benefits, including supporting gut health and increasing GLP-1 levels. Almonds, walnuts, chia seeds, and flaxseeds are particularly rich in fiber, healthy fats, and antioxidants that can stimulate GLP-1 secretion. 

Snacking on a handful of nuts or seeds, adding them to salads, yogurt, or smoothies, or using them as a topping for oatmeal or baked goods are all easy ways to incorporate these nutritious foods into your diet.

Lean proteins

Lean proteins can increase GLP-1 levels and help maintain muscle mass. This is helpful for people taking GLP-1 medications like semaglutide since muscle loss and body fat often occur. 

It’s important to offset this by eating as much lean protein as possible. Examples of lean proteins include fish, chicken, turkey, and eggs. Lean cuts of beef, cottage cheese, and tofu are also great sources of lean protein.

Keep in mind: Protein may also naturally reduce your appetite.

Curcumin

Curcumin is the main compound found in turmeric, a spice widely used in traditional Indian cuisine and known for its potent anti-inflammatory and antioxidant properties. Studies have suggested that curcumin may decrease blood sugar and increase GLP-1 levels. However, more research is needed to fully understand the mechanisms underlying its effects on GLP-1 and its potential therapeutic applications in metabolic disorders.

Yerba Mate

Yerba mate is a traditional South American beverage made from the leaves of the Ilex paraguariensis plant. It is known for its stimulating effects due to its caffeine content. It also contains polyphenols and saponins, which have been studied for their potential health benefits, including fat loss and appetite reduction.

Berberine

Berberine is a plant-based compound found in goldenseal, barberry, and Oregon grape. It has been used in traditional Chinese medicine for centuries to treat various ailments, including digestive disorders and diabetes. Berberine has garnered attention for its ability to modulate glucose and lipid metabolism, partly through its effects on GLP-1 secretion.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market. 

Peptide therapies have gained significant attention in modern healthcare, offering targeted solutions for a range of health concerns. Peptide therapies may help increase natural human growth hormone (HGH) levels, improve gut health, and promote tissue healing. There are also peptides for weight loss, sleep, brain health, sexual wellness, and skin health. 

As the demand for these therapies grows, so does the number of peptide clinics catering to people looking for these innovative treatments. 

In this podcast, we'll talk about how you can choose the best peptide clinic to ensure you make an informed and safe decision about your health. 

1. Expertise and Credentials

First and foremost, research the clinic's medical professionals. Verify their qualifications, experience, and specialization in peptide therapies to make sure you're in capable hands. You'll also want to check that they have the necessary credentials to administer peptide therapies. A clinic with knowledgeable professionals inspires confidence in the quality of care you'll receive.

2. Customization

Peptide therapies aren't one-size-fits-all solutions. Look for a clinic that tailors treatments to your unique health profile and goals. A customized approach ensures you receive the most suitable peptide therapy.

3. Research and Evidence-Based Approach

A reputable peptide clinic should have staff that stay updated with the latest research in peptide therapies. An evidence-based approach ensures you receive treatments rooted in scientific knowledge.

4. Transparent Pricing

Peptide therapies can be expensive. They can also vary in cost from one clinic to another. Finding clinics that provide clear, transparent pricing (no hidden fees) is important. A reputable clinic should provide pricing information for consultation fees, treatment costs, supplies, and additional services. Understanding pricing upfront can prevent unexpected financial burdens during your peptide wellness journey.

5. Consultation Process

A thorough initial consultation is essential for a successful peptide therapy journey. The clinic should discuss your past and current medical history, current medications, allergies, lifestyle, and current goals.

6. Safety Protocols, Monitoring, and Follow-up

Safety is paramount. Ask about the clinic's safety protocols, including the monitoring process during and after treatment. Regular follow-ups should be standard throughout your peptide journey.

7. Communication and Accessibility

Effective communication is key. Opt for clinics with accessible and responsive communication channels to make it easy to ask questions, address concerns, and schedule appointments (e.g., website, text, email, phone call). 

8. Legal and Ethical Compliance

Verify that the clinic operates ethically and complies with all state/country laws and regulatory standards. 

9. Facility Hygiene

Visit the clinic before your initial consultation if possible. A clean and well-maintained environment is indicative of their commitment to patient safety.

10. Success Stories

Don't be shy. Ask for success stories or case studies showcasing positive outcomes from the peptide therapies offered.

11. Accessibility

Consider the clinic's location and hours of operation to save time and hassle, particularly if you require regular appointments. Additionally, check if the clinic offers flexible hours or virtual appointments to accommodate your schedule. 

12. Privacy and Confidentiality

Your medical information should be treated with the utmost confidentiality. Ensure the clinic has privacy measures in place.

13. Patient Education

A reputable clinic should educate you about your peptide options, potential side effects, and expected outcomes. It should also go over your peptide dose, frequency, and how to store it. And if injections are necessary, the clinic should show you how to give yourself a shot.

14. Peptide Quality and Purity

Under certain conditions, the FDA allows pharmacies to make medications with a drug shortage. Peptides are produced by specialized pharmacies that source pharmaceutical-grade active ingredients (amino acids in this case) and combine them to make a finished medication or product. 

If you're going to purchase your peptide therapies through a compounding pharmacy or a clinic, you'll want to make sure that you ask if the peptide was made at a facility that's registered with the FDA and follows good manufacturing practices at their facility. This will ensure that the peptides you receive don't contain extra ingredients and is safe for use.

15. Gut Feeling

Lastly, trust your gut. If a clinic doesn't feel right or doesn't meet your expectations, continue your search until you find one that aligns with your needs. You can also contact your PCP or favorite pharmacist for clinic recommendations.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

Pro Tips

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. 

This week we are continuing our mini-series on low testosterone (low T).

Last week we covered clinical options to help replace testosterone, but there are many ways to boost your testosterone naturally. Today we'll go over our favorite natural ways to help boost your low T to increase your energy, control body fat distribution, and maintain muscle and bone growth. All this and more in less than 5 minutes.

Does food affect testosterone?

You don't have to be a nutritionist to know that our diets are important for overall health. Think back to the last time you overindulged in a big meal or fast food. As you finished your meal, you may have felt tired or sluggish. The food you eat should always make you feel your best so that you have the fuel to function properly — which includes the production and metabolism of hormones like testosterone.  

There are many claims that certain foods can increase your testosterone levels. Some people believe that onions, garlic, ginger, shellfish, and fatty fish like tuna and salmon will help increase low T. Others believe that leafy green vegetables like spinach and kale, bananas and pomegranates, and eggs will help. 

Why do people think that certain foods can boost low T?

Because testosterone helps to maintain muscle and bone growth and helps with energy levels, the idea of eating certain foods to boost low T has emerged.

What does the science say?

Many factors can, in fact, affect testosterone levels, with diet being one of them. Not getting enough nutrients like magnesium, vitamin D, and zinc can indirectly influence testosterone levels. 

It's important to remember that research has shown that a healthy diet and lifestyle might affect low T, but certain food probably won't increase your testosterone levels. You must have testosterone supplementation.

However, you can use diet to potentially keep your testosterone levels from dropping. Eating a diet rich in protein, complex carbohydrates (e.g., oats, quinoa, legumes, sweet potato), and healthy fats (e.g., avocado and fatty fish like tuna and salmon) may help maintain your testosterone levels.  

You can increase your vitamin D levels by eating fatty fish, spending more time in the sun, and taking supplements.

Minimize your stress

Easier said than done, right? Studies have shown that continued exposure to stress increases your levels of cortisol. We've discussed cortisol in our other podcasts. But as a refresher, cortisol is a hormone released into your bloodstream that causes an increase in your heart rate and blood pressure. It's your natural "fight or flight" response. However, over time, if your body experiences repeated stress, you may begin to feel tired, irritable, depressed, and even experience weight gain. Cortisol also helps your body break down fats and suppress inflammation. This elevated cortisol decreases testosterone production.

Maintain a healthy weight 

Extra belly fat has aromatase. Aromatase is an enzyme that converts testosterone into estrogen. And extra estrogen will trigger your body to make less testosterone. This is a nasty cycle where the more belly fat you accumulate, the less testosterone your body makes.

Drink less alcohol

Studies have shown that alcohol can decrease the enzyme responsible for testosterone production. Heavy drinking can increase cortisol levels, cause weight gain, and reduce testosterone production. 

Get more sleep

Studies have shown that as little as 1 week of sleep deprivation can lower testosterone levels by 10% to 15%. 

You can find more information at pepties.com. That's peptides without the D. Where we are tying all the peptide information together. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. We hope you enjoyed the testosterone mini-series. If you love this podcast, please share it with your friends and family on social media. Have a happy, healthy week!

Pro Tip

We're huge advocates of using daily collagen peptide supplements in your routine to help with skin, nail, bone, and joint health. But what do you know about peptides for health and wellness?

Giving yourself a peptide injection can be scary or confusing. But we've got you covered. Check out 6 tips to make peptide injections easier. And, make sure you have the supplies you'll need. This may include syringes, needles, alcohol pads, and a sharps container.

Curious about how tirzepatide can help with weight loss?  From understanding how it works to managing potential side effects, many have questions about this medication. 

In this podcast, we’ll discuss the top questions to give you a clearer picture of how tirzepatide might fit into your weight loss journey.

How does tirzepatide work for weight loss?Tirzepatide, marketed as Zepbound, mimics the action of GLP-1 and GIP, two hormones naturally released by your gut. These hormones are critical in regulating appetite and how much food you consume. By enhancing the feeling of fullness and reducing hunger, tirzepatide helps support weight loss. Specifically, it has the following effects:

• Slows stomach emptying, helping you feel full longer after meals.

• Decreases appetite, leading to reduced food intake.

• Reduces food cravings.

• Stimulates the pancreas to release more insulin, which lowers blood sugar levels.

• Reduces the liver’s new glucose production, further improving blood sugar control.

These combined effects make tirzepatide a powerful tool for weight management and improving metabolic health.

1. How long does it take for tirzepatide to work?

In clinical trials, people typically began to notice weight loss around 4 weeks after starting tirzepatide. This is when the medication reaches stable levels in the body. The trial lasted for 72 weeks, and the participants continued to lose weight throughout the study. However, the most significant results were observed during the first 8 to 9 months of treatment.

2. How much weight do people lose with tirzepatide?

Tirzepatide is one of the most effective weight-loss treatments available. In clinical trials, people lost, on average, between 15% and 21% of their starting body weight after 72 weeks of treatment. 

Additionally, longer treatment with tirzepatide tends to lead to more significant weight loss. People in two different studies lost an average of 25% of their starting body weight when using tirzepatide for an extended period. 

3. What’s the typical tirzepatide dosage for weight loss?

The initial tirzepatide dosage is 2.5 mg once a week for the first 4 weeks. After that, the dose is increased to 5 mg weekly. Most people remain on the 5 mg dose for the long term. If necessary, the dose can be gradually increased. But the increases should be by no more than 2.5 mg at a time, and there should be at least 4 weeks in between each one. The maximum tirzepatide dose is 15mg weekly.

4. How long does tirzepatide stay in your system?

Tirzepatide has a half-life of about 5 days, meaning that it takes this amount of time for your body to eliminate half of the medication. This helps determine when a medication starts wearing off and influences its dosing schedule. Since Tirzepatide’s half-life is 5 days, it only needs to be injected once weekly.

On the other hand, a longer half-life means it takes more time for your body to fully eliminate a medication. In the case of tirzepatide, small amounts of the medication may remain in your system for up to 25 days after a dose.

5. How long do you need to take tirzepatide?

The duration of tirzepatide treatment depends on your health and weight loss goals. It’s best to work with your healthcare provider to determine a timeline that suits your needs. Keep in mind that tirzepatide is designed for long-term use. Still, it may only be needed temporarily if you're able to adopt and sustain certain lifestyle changes after discontinuing the medication .

Research shows that maintaining weight loss with tirzepatide is achievable with continued use. At the end of clinical trials, nearly 90% of participants maintained at least 80% of the weight they lost during the first 8 to 9 months. 

If you plan to stop taking tirzepatide, it’s important to work with your healthcare provider to develop a strategy to help maintain your weight loss. They can help create a plan to continue important lifestyle changes such as proper nutrition, regular physical activity, stress management, and quality sleep. 

6. Can you change your tirzepatide injection day?

Yes, you can adjust your tirzepatide injection day if needed (e.g., illness, vacation, side effects), but there are specific guidelines to follow.

When switching injection days, make sure there’s at least a 3-day (72-hour) gap between two doses. For instance, if you typically inject on Saturdays, you could move it to Tuesday (or another later day in the same week). 

It's important to consult your healthcare provider before making this change. They can give you a safe and appropriate schedule based on your circumstances.

7. Can you switch from semaglutide to tirzepatide?

Yes, you can switch from semaglutide to tirzepatide if you need additional support with weight management. 

Based on your current semaglutide dosage and any side effects you're experiencing, your healthcare provider may begin you on a lower dose of tirzepatide. This approach allows your body to adjust to tirzepatide and helps determine your optimal dose.

It’s important to note that some individuals transitioning from semaglutide to tirzepatide report that semaglutide remains more effective in various aspects, including appetite suppression, managing food cravings, and achieving weight loss goals. 

They often note that semaglutide helps reduce "food noise," or the persistent thoughts about food, more effectively than tirzepatide.

This variation in response highlights the individual nature of weight management medications, suggesting that while tirzepatide may work well for many, semaglutide may better address specific needs for others, particularly in controlling cravings and enhancing overall satiety.

8. What are the most common side effects of Tirzepatide?

The most frequently reported side effects are nausea and constipation. Less commonly, you might experience other gastrointestinal issues such as indigestion, vomiting, diarrhea, burping, and flatulence. Some people have also reported headache and fatigue.

9. How do I manage constipation on tirzepatide?

1. Drink plenty of fluids to stay hydrated and help prevent constipation. To estimate your daily water intake, take your weight in pounds and divide it by two. This will give you the approximate number of ounces of water you should drink each day. For instance, if you weigh 200 pounds, you should aim for about 100 ounces (or 3 liters) of water daily. This amounts to roughly five 20-ounce bottles of water each day. You should drink more if you live in warmer, humid climates or work outside.

2. Engage in exercise 3-4 times a week to support regular bowel movements. This can be as simple as walking 10 to 15 minutes after each meal. 

3. Get more fiber. If you’re a woman, you should consume 25 grams of dietary fiber each day to prevent constipation. You should consume 38 grams of dietary fiber each day if you're a man. Try eating more whole grains, fruits, and vegetables to get more fiber. Beans, nuts, and seeds are also a great source of dietary fiber. Remember that consuming too much fiber is possible, particularly if you increase your intake suddenly. Excessive fiber can cause bloating, gas, and constipation. To avoid these issues, gradually introduce more fiber into your diet. 

4. Consider using Metamucil or a stool softener such as docusate sodium if necessary. But always check with your healthcare provider first. They can make sure it’s safe for you to take.

10. How do I manage nausea on tirzepatide?

Staying hydrated and eating small meals may help. Try to avoid spicy, greasy, or fried food. These foods can irritate the stomach lining and make nausea worse. If nausea persists or becomes severe, consulting with your healthcare provider is important, as they may recommend anti-nausea medications or adjust your tirzepatide dose. 

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

The benefits of losing weight go far beyond looking and feeling good. Weight loss is often accompanied by numerous health benefits, from improved cardiovascular health to better metabolic function. However, for some people, shedding those extra pounds may also come with an unexpected side effect: hair loss. 

While this can be distressing, it's important to understand that hair loss isn't directly caused by GLP-1 agonists but rather by rapid weight loss and other associated factors.

As a refresher, let’s discuss how GLP-1 agonists work for weight loss. 

Medications like semaglutide mimic the action of glucagon-like peptide-1 (GLP-1), a hormone that regulates blood sugar levels and controls appetite. They also slow down how fast food leaves your gut, making you feel fuller after you eat.

What causes hair loss?

Hair loss can occur for many reasons, including genetics, hormonal imbalances, nutrient deficiencies, stress, and certain medications. But when it comes to weight loss, several factors can contribute to hair loss.

Nutritional Deficiencies: Rapid weight loss caused by diet can lead to inadequate intake of essential nutrients such as vitamins, minerals, and proteins. These nutrients are vital for healthy hair growth. For example, deficiencies in iron, zinc, biotin, and protein have been linked to hair loss.

Telogen Effluvium: This is a type of temporary hair loss that occurs when a significant number of hair follicles enter the resting (telogen) phase prematurely due to stress or shock to the body, such as rapid weight loss. This results in increased shedding of hair and typically starts about 3 months after someone experiences a stressful life event or rapid weight loss.

It's important to note that GLP-1 agonists themselves do not directly cause hair loss. Clinical trials and studies evaluating the safety and efficacy of these medications have not reported hair loss as a common side effect. This means there’s no evidence that taking any GLP-1 agonist directly causes hair loss. 

If you're experiencing hair loss while taking a GLP-1 agonist for weight loss, it's important to know that this hair loss isn’t permanent. After a few weeks to months, hair follicles will return to their usual growth patterns.  

If you notice hair shedding or thinning after you start a GLP-1 agonist, make sure to talk with your healthcare provider. They can help determine the underlying cause of your hair loss and recommend appropriate interventions. 

Additionally, adopting a well-balanced diet and ensuring adequate nutrient intake can support healthy hair growth during weight loss. You should try to include lean proteins, fruits, whole grains, and vegetables in your daily routine.

You’ll also want to work on lowering your stress levels. You can try meditation, regular physical activity, and deep breathing. You can also try to schedule mindfulness breaks throughout your day (e.g., drinking a cup of tea, calling a friend, or cleaning your workspace) or reduce loud noise in your work or home environment.

Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!

We’re huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it’s a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 

Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.