The Aliquot Preview (Rhonda Patrick, Ph.D.)
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| Date | Titre | Durée | |
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| 01 Jul 2021 | PREVIEW Aliquot #34: How fasting influences immune function | 00:20:33 | |
Dr. Rhonda Patrick and Dr. Valter Longo describe the roles that diet and fasting play in maintaining or restoring proper immune function. Diet plays essential roles in immune function. Consequently, deficiencies or insufficiencies in vitamins or minerals can impair immune function. The gut microbiota also modulates immune function, so maintaining a healthy gut is crucial. However, when the immune system becomes overactive, autoimmune disorders can arise. A growing body of evidence indicates that the fasting-mimicking diet may be beneficial in treating autoimmune disorders. Diet plays an essential role in immune function. Consequently, deficiencies or insufficiencies in vitamins or minerals can impair immune function. The gut microbiota also modulates immune function, so maintaining a healthy gut is crucial. However, when the immune system becomes overactive, autoimmune disorders can arise. A growing body of evidence indicates that the fasting-mimicking diet may be beneficial in treating autoimmune disorders. In these Aliquot segments, Dr. Rhonda Patrick and Dr. Valter Longo describe the roles that diet and fasting play in maintaining or restoring proper immune function.
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| 14 Jan 2023 | PREVIEW Aliquot #78: The minimum effective dose for hypertrophy | 00:20:55 | |
Incorporating resistance training into your exercise regimen presents a scheduling dilemma – there's simply not enough time. Performing time-efficient workouts that involve supersets, paired sets, drop sets, and multi-joint exercises decrease training time while providing the minimum effective dose necessary for muscle hypertrophy. In this Aliquot, experts Dr. Brad Schoenfeld and Dr. Stuart Philips provide tips for optimizing gym time and share the workout routines and healthy lifestyle behaviors they practice to promote healthy aging.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, every-other-week Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 31 Aug 2021 | PREVIEW Aliquot #38: Zinc's role in brain and immune health | 00:19:29 | |
Zinc is an essential nutrient that participates in many biological processes and plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, cell division, and brain health. Zinc deficiency puts a person at risk for a subtype of Alzheimer's disease and poor immune function. In this Aliquot, Drs. Dale Bredesen and Rhonda Patrick describe some of the many roles that zinc plays in human health.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 30 Apr 2024 | PREVIEW Aliquot #106: The Science of Longevity Vitamins: Taurine, Ergothioneine, and PQQ | 00:35:17 | |
Get more Aliquots! Become an FMF Premium Member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, every-other-week Science Digest emails, and more. Learn more about The Aliquot podcast here Vitamins are substances that our bodies need to develop and function normally. When considering vitamins, we tend to think of the usual suspects – A, C, D, E, and K, plus the eight B vitamins. However, the body produces many molecules that fit the description of a vitamin, driving physiological processes from infancy through later life. Some of these molecules might even be considered longevity "vitamins" – substances that extend healthspan and promote a longer life. In this Aliquot, I talk about three substances that may act as longevity vitamins – taurine, ergothioneine, and PQQ. This episode includes several key discussion points:
For a deeper foray into this special topic, I highly recommend reading Dr. Bruce Ames' seminal paper, Prolonging healthy aging: longevity vitamins and proteins, published in the Proceedings of the National Academy of Sciences. This open-access article explores a range of compounds, including taurine, PQQ, and ergothioneine, which Dr. Ames identifies as potential longevity vitamins. The study provides valuable insights into how these vitamins and proteins could contribute to extending healthy lifespan. This episode features segments taken from several Q&As with Dr. Rhonda Patrick. You may view these episodes and their show notes here: | |||
| 18 Apr 2023 | PREVIEW Aliquot #85: The Science of Wrinkle Prevention ⎯ Building Resilient Skin | 00:25:40 | |
Your skin is a crucial barrier to the outside world – the first line of defense against environmental exposures, and the primary means by which the body retains fluids necessary for survival. Consequently, maintaining a healthy skin barrier is important for your overall health. In this Aliquot, I describe some things you can do to protect your skin and possibly prevent wrinkles, too.
This episode features a variety of segments from various episodes of our members Q&A series: Q&A #11 (cocoa), Q&A #13 (toxin absorption through skin), Q&A #35 (sugar intake), Q&A #38 (skin cell senescence), Q&A #41 (collagen supplementation), Q&A #42 (my skincare routine). Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, every-other-week Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 25 Feb 2021 | PREVIEW Aliquot #22: Q&A Mashup - Rhonda's personal supplement routine | 00:20:26 | |
This episode covers many supplement-related topics including:
Please note that the information in this episode is based on Rhonda's own personal experience and is not medical, professional, or licensed advice. If you are thinking about starting or changing your own supplement routine, please make sure you consult your physician or health care provider. | |||
| 01 Apr 2021 | PREVIEW Aliquot #25: Coffee, caffeine, and sleep | 00:25:31 | |
Coffee consumption is associated with protection from several chronic diseases, including cancer, cardiovascular disease, and neurodegenerative disease. Whereas some of the beneficial effects of coffee may stem from its ability to induce autophagy, other evidence points to the benefits of caffeine, which, when consumed early in the morning – resets the body's internal clocks and provides a mental boost that helps us start the day and may even protect telomeres. But the long half-life of caffeine can reduce sleep quality, fueling a vicious cycle of poor sleep, daytime grogginess, and increased caffeine consumption. This Aliquot segment features Dr. Guido Kroemer, an expert in immunology, cancer biology, aging, and autophagy; Dr. Satchin Panda, an expert in circadian rhythm research; Dr. Matthew Walker, a professor of neuroscience and psychology; Dr. Elissa Epel, an expert in telomere biology; and Dr. Rhonda Patrick (in an interview with Mike Maser).
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. | |||
| 14 Jun 2021 | PREVIEW Aliquot #30: Lifestyle modifications that enhance immune health | 00:20:00 | |
Having a healthy, robust immune system is crucial for our survival. Critical players in the body's antiviral immune response are interferons. Certain lifestyle behaviors can boost interferon production and immune function, including sleep, vitamin D, and hot hydrotherapy. This Aliquot segment features Dr. Roger Seheult, a quadruple board-certified physician serving on the frontlines of COVID-19 care and co-founder of MedCram.
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| 30 Nov 2021 | PREVIEW Aliquot #43: Protein consumption: Finding the Balance | 00:33:33 | |
Protein is essential for maintaining muscle mass as we age. Modulating protein intake via dietary intake or fasting can have variable effects on aging and muscle growth. Whereas fasting turns off multiple pathways associated with aging, such as mTOR, IGF-1, growth hormone, and others, eating for optimal fitness activates these important processes. In this aliquot, we discuss:
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 18 Oct 2021 | PREVIEW Aliquot #41: Q&A and Interview Mashup - Blood Tests, Biomarkers, and Lab Work | 00:18:10 | |
“If you can not measure it, you can not improve it.” - William Thompson Getting regular checkups and undergoing blood tests are fundamental to maintaining good health. FMF guests with expertise ranging from lipid metabolism to Alzheimer's disease risk to micronutrient status have shared their recommendations regarding blood tests that a person should consider adding to their yearly checkup. This Aliquot brings many of those conversations together in one place.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: www.foundmyfitness.com/aliquot | |||
| 30 Apr 2021 | PREVIEW Aliquot #26: How mRNA COVID-19 Vaccines Work | 00:10:59 | |
Traditional vaccines take many years to develop. A recent innovation in vaccine technology involves exploitation of messenger RNA, or mRNA, to facilitate rapid scaling of vaccines and expedite their modification if the virus mutates significantly. The Pfizer and Moderna COVID-19 vaccines capitalize on this technology to induce antibody production against the SARS-CoV-2 virus. In this episode, we discuss:
This Aliquot segment features Dr. Roger Seheult, a quadruple board-certified physician serving on the front lines of COVID-19 care and co-founder of MedCram. | |||
| 25 Feb 2021 | PREVIEW Aliquot #2: Q&A Mashup - Sauna | 00:18:30 | |
a collection of clips that covers some of the many health benefits associated with sauna use, including heat shock protein activation, cardiovascular health, muscle mass preservation, and more. In this episode, you'll discover:
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| 20 Jun 2022 | PREVIEW Aliquot #59: How alcohol affects sleep, behavior, and cancer risk | 00:32:28 | |
Alcohol, one of the most used drugs worldwide, is a controversial subject. Whereas some research suggests drinking alcohol improves health, an abundance of evidence indicates that drinking alcohol also harms health. Particularly, higher alcohol intake is associated with an increased risk of many cancers. Some of the deleterious effects of drinking may be due to alcohol's effects on sleep. Although alcohol may help us feel calm and ready to sleep, it has surprising effects on REM sleep and maybe our waking behaviors too. In this Aliquot, we discuss some of the risks and surprising effects of alcohol on human health and behavior.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 04 Apr 2022 | PREVIEW Aliquot #54: Dietary and environmental factors that may impact autoimmune diseases | 00:30:08 | |
Autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, and multiple sclerosis occur when the immune system mistakes the body's own proteins for those released by invading pathogens. The immune system has strategies for filtering these autoimmune cells out of circulation; however, this filter can malfunction due to age, genetic predisposition, disruption of the gut barrier and gut microbiota, or other environmental exposures. In this episode of the Aliquot podcast, we'll discuss autoimmunity and how childhood exposure to germs, dietary fiber intake, and fasting can build a healthy and balanced immune system.
Watch the full episode featuring Dr. Eran Elinav Watch the full episode featuring Drs. Erica & Justin Sonnenburg Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 25 Feb 2021 | PREVIEW Aliquot #3: Q&A Mashup - Fasting | 00:27:43 | |
is a collection of clips that covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, health benefits, and when and how to break the fast. In this episode, you'll discover:
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| 19 Jul 2022 | PREVIEW Aliquot #61: How dietary fiber influences metabolic health | 00:32:02 | |
Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasing micronutrients trapped in the fiber matrix and producing beneficial metabolic byproducts, such as short-chain fatty acids. Fiber exerts a wide array of beneficial health effects, influencing metabolic health, and may be an important, if overlooked, component of ketogenic diets. In this Aliquot, Dr. Michael Snyder, Dr. Dominic D'Agostino, and Dr. Rhonda Patrick discuss the benefits of dietary fiber.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 31 Aug 2022 | PREVIEW Aliquot #65: Concerns with chronic NSAID use | 00:26:59 | |
Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most widely used drugs worldwide, available in both prescription and over-the-counter forms, such as aspirin, ibuprofen, naproxen, and others. Most NSAIDs, with the exception of aspirin, work by inhibiting the activity of a family of enzymes called cyclooxygenases, which drive inflammatory processes. But because these inflammatory processes can be beneficial in some contexts and because the drugs often elicit off-target effects, there are some concerns about their use.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 11 Aug 2023 | PREVIEW Aliquot #92: The Underestimated Role of Resistance in Body Recomposition | 00:36:51 | |
Having a healthy body composition, with plenty of lean mass – in the form of muscle and bones – is essential for health throughout the lifespan. Achieving a healthy body composition requires a balanced approach that emphasizes resistance training – and calorie reduction where appropriate. In this Aliquot, Dr. Brad Schoenfeld describes a balanced approach to maximizing muscle growth and strength and dispels early myths about possible blunting effects of aerobic training, the need to train to failure, and the "go heavy or go home" philosophy. Here's what you'll find in this episode...
If you are interested in muscle hypertrophy and body composition, you may be interested in our member's Q&A series where you ask a question and I answer it:
Get more Aliquots! Become an FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, every-other-week Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 16 Feb 2022 | PREVIEW Aliquot #51: What's the best omega-3 dosage for maximum benefit? | 00:53:01 | |
Early studies of omega-3 fatty acid intake demonstrated dramatic biological effects. Since then, the body of research enumerating the profound anti-inflammatory and multi-system, generalized health-promoting qualities of omega-3s continues to grow; however, some studies fail to show any effects from omega-3 supplementation. This source of consternation may, by and large, boil down to low doses, raising the question: what is the right dose of omega-3 to use? In this Aliquot, Dr. Bill Harris shares his experience administering some of the largest omega-3 doses ever used in human trials and gives his recommendations about optimal dosage taking genes and diet into account.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 22 Oct 2022 | PREVIEW Aliquot #70: Preventing age-related muscle loss | 00:32:20 | |
The progressive loss of skeletal muscle mass and strength that occurs with aging, referred to as sarcopenia, begins as early as our 30s or 40s. Many factors contribute to sarcopenia, including diet and inactivity. Building muscle mass in one's early years is essential for staving off the age-related loss of muscle mass and may promote longevity. In this Aliquot, Dr. Stuart Phillips discusses the importance of building muscle through resistance training and why starting early is important.
Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, every-other-week Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot | |||
| 25 Feb 2021 | PREVIEW Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health | 00:36:26 | |
Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer. Balancing the beneficial and (sometimes) harmful effects of IGF-1 via exercise and fasting is critical to maintaining health. In this episode, we discuss:
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| 25 Feb 2021 | PREVIEW Aliquot #6: Genetic and lifestyle risk factors for Alzheimer's disease | 00:19:01 | |
The single most important genetic risk factor for Alzheimer's disease is a variant of apolipoprotein E, or APOE for short, a lipoprotein produced in the liver and brain. Roughly a quarter of all people living in the US – about 75 million people – carry a genetic variant of APOE called APOE4. Having APOE4 is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease. But having APOE4 doesn't mean that Alzheimer's disease is inevitable. In fact, lifestyle behaviors can modulate risk for the disease, too, especially sleep, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk. Understanding our genetic risks and addressing lifestyle behaviors – especially our sleep patterns – can influence whether a person eventually develops Alzheimer's disease. These Aliquot segments feature Dr. Dale Bredesen, a professor of neurology, and Dr. Matthew Walker, a professor of neuroscience and psychology.
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| 25 Feb 2021 | PREVIEW Aliquot #8: Lifestyle interventions for depression and anxiety | 00:15:56 | |
features Dr. Charles Raison, a professor of psychiatry. Various ancient practices, including meditation, hot yoga, and sauna, may aid in the treatment of depression. Whether the medical community will embrace these lifestyle interventions remains to be seen. In the meantime, most people with clinical depression are treated with antidepressants. These drugs have their advantages and disadvantages, and while they are helpful for a subset of depressed people, a quarter of patients taking the drugs may get worse. In this clip, Dr. Charles Raison discusses his belief that ancient practices are more likely than modern pharmacology to encourage resilience and stave off depression and describes how antidepressants have their place in treating depression, but they should be used with caution due to some of their inherent side effects.
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| 25 Feb 2021 | PREVIEW Aliquot #16: Time-restricted eating for better metabolic health - Part 1 | 00:24:38 | |
Time-restricted eating, which involves taking in food within a small window of time during the day and fasting for the remainder, can improve certain biomarkers of health – even without weight loss – to improve overall health. In Part I of this two-part segment, Drs. Satchin Panda and Ruth Patterson describe how eating following the body's circadian clock – eating during the day and fasting at night – enables the body to focus on repair rather than on the digestion of food. In this episode, we discuss:
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| 25 Feb 2021 | PREVIEW Aliquot #1: Q&A Mashup - Pregnancy and Child Development | 00:22:38 | |
is a collection of clips that covers a range of topics related to optimizing a child's development and growth, from pregnancy to toddlerhood. In this episode, you'll discover:
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