Longevity Roadmap (Buck Joffrey)

Buck discusses Yamanaka Factors and recent experiments where a team led by David Sinclair was successful in reversing cellular age applying the concepts in an experiment.

• 00:00:02 - Is it possible to stop or even reverse the aging process?
• 00:01:48 - 2012 research by Shinya Yamanaka - Yamanaka Factors 
• 00:02:50 - Pluripotent stem cells
• 00:03:08 - Revolutionary discovery for the world of regenerative medicine 
• 00:03:28 - Salk Institute study using mice with progeria
• 00:03:55 - Doxycycline and improvements in signs of aging
• 00:04:26 - David Sinclair's research to regenerate optic nerves in mice to restore vision
• 00:04:49 - David Sinclair's book on aging research called Lifespan
• 00:05:20 - Epigenome and the aging process
• 00:06:15 - Horvath lab and using Yamanaka factors to reset epigenetic clocks in rats

In this brief video, Buck Joffrey discusses literature suggesting that there is a "Goldilocks" zone for exercising for longevity. He also talks about the research on ultramarathoners suggesting that the once an upper limit of exercise is exceeded, risks to health potentially outweigh the benefits.

Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns.

Show Notes:

2:55 A plant-based diet for better health?

11:53 Balancing nutritions for the plant-based diet

20:39 Accessibility of the plant-based diet

22:30 Processed plant-based food

What if aging isn’t just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift.

He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research.

Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down.

Learn more about Dr. Matt Kaeberlein and Optisan:

https://www.optispan.life/

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Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study itself, including some suggestions on how to use this new information.

Show Notes:

02:01 Intermittent fasting vs caloric restriction

06:57 Why Intermittent Fasting Improves Metabolic Health

10:19 Intermittent fasting while maintaining a healthy diet

12:32 The study

19:35 What does this study mean to Buck?

In this Medical Update, Buck talks about one quick thing you can do to significantly improve the quality of your sleep. It goes against what we've been told but everyone should do it. The data backs it!

In this two part episode Buck discusses male sexual health with Justin Houman, MD from Tower Urology in Los Angeles. Over half of American men over the age of 40 suffer from erectile dysfunction and other sexual disorders. Buck asks the questions many men are uncomfortable asking.

00:01:44 - The concept of Erectile Dysfunction

• 00:06:22 - Diagnosing Erectile Dysfunction
• 00:09:33 - What is sex therapy?
• 00:10:56 - Main causes of Erectile Dysfunction
• 00:12:02 - Testosterone Levels
• 00:15:48 - Venous Leak
• 00:17:32 - Erectile Dysfunction Treatment
• 00:20:54 - PDE5 inhibitors
• 00:26:14 - Erectile Dysfunction and Cardiovascular Disease?
• 00:31:38 - Intracavernosal injections
• 00:37:13 - GAINSWave Procedure
• 00:42:53 - Platelet-Rich Plasma (PRP) Injection

Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer’s disease.

Show Notes:

1:27 Is it true that the testosterone in men in general has gone down?

02:43 Common symptoms of low testosterone

05:15 Normal level of testosterone

07:19 Testosterone and metabolic syndrome

12:49 Testosterone replacement therapy and cancer

16:03 Downside of testosterone replacement therapy

19:18 Different options to supplement testosterone

29:03 What’s on the horizon?

32:50 ED and cardiovascular diseases

38:35 Should all 40+ men be on daily Cialis?

40:43 Penile pump

In this special New Year episode, Buck reviews some of the concepts discussed on the show in 2023.

In this episode, Dr. Vera Gorbunova unpacks the secrets of nature’s longest-lived species—like the naked mole rat and bowhead whale—to uncover the biological mechanisms that keep them healthier for longer. We explore the role of DNA repair, transposable elements, and epigenetics in aging and what these discoveries could mean for human longevity. From mitochondrial function to promising interventions like fucoidan, can we apply nature’s blueprint to extend our own lifespan?

Buck and Nikki sit down with Dan Buettner, creator of the Netflix series Live to 100: Secrets of the Blue Zones, to explore the wisdom of the world's longest-lived populations. They dive into the lifestyle, diet, and environmental factors that contribute to longevity, and how you can engineer these principles to extend your healthy lifespan.

Dr. Robert Lustig joins Buck to discuss the alarming state of metabolic health in America, where only 7% of the population is considered metabolically healthy. He breaks down metabolic dysfunction, linking it primarily to mitochondrial inefficiency, and explains how sugar—especially fructose—plays a major role in various health issues.

The conversation explores the dangers of ultra-processed foods, identifying key contributors to metabolic dysfunction, including excessive sugar, insufficient fiber, and emulsifiers in processed foods. Dr. Lustig also examines the impact of hyperinsulinemia, the effects of fructose on liver health, and the role of branched-chain amino acids in metabolism.

Beyond diet, he highlights the importance of understanding how insulin, amino acids, and mitochondrial function influence overall metabolic health. The discussion touches on inflammation, the challenges of making healthy choices in grocery stores, and the pros and cons of different diets, including ketogenic and carnivore diets. Lustig also underscores the significance of fasting insulin as a key marker of metabolic dysfunction and explores how nutraceuticals can support mitochondrial health.

Learn more about Dr. Robert Lustig:

https://robertlustig.com/

PERFACT – A tool for filtering healthier grocery items:

http://perfact.co

Blue Oak Nutraceuticals – Maker of Mitocatalyst E:

https://blueoaknx.com

Buck Joffrey, MD interviews Dr. Daniel Bowling from Stanford University on the science behind music and mental health. Bowling discusses the fundamentals of musicality and the research that has been done in this relatively new field of music as treatment for health-related issues.

Show Notes:

02:59 What is musicality?

04:47 What is tonality?

07:05 How does music affect the brain?

11:20 Music as treatment for mental health

22:22 Does music sharpen our intellect?

27:05 Musical vs pharmaceutical interventions

30:38 How to get started on music therapy

Topics include:

00:40 Is Weightloss Simply Calories In and Out?

07:10 Stem Cell Injections for NBA Players?  

14:60 Statins for Lowering Cholesterol

23:19 The Impact of Nature and Nurture on Longevity

Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID.

02:07 What are Mitochondria?

05:05 Mitochondrial Dysfunction and Aging

12:13 Mitochondrial Genetics and Inheritance

14:54 Innovative Approaches to Mitochondrial Health

17:58 Pharmaceuticals and Supplements for Mitochondrial Support

🎧 Dive deep into the world of weight loss solutions in this eye-opening episode of Sapio with Buck Joffrey. As the buzz around Wegovy and Ozempic intensifies, we dissect the promises and pitfalls. Can it truly tip the scales in favor of those battling the bulge? Join us for an exploration of this groundbreaking treatment.

👍 Like, share, and weigh in: Would you consider Wegovy as a weight loss solution? #SapioPodcast #BuckJoffreyInsights #WegovyExplained #TippingTheScales #WeightLossInnovation #BeyondTheBuzz #HealthTrends #ModernMedicine #WeightLossJourney #DiabetesToDiet #Wegovy #Ozempic #semaglutide

Buck Joffrey interviews Martin Gibala, a professor at McMaster University, about High-Intensity Interval Training (HIIT) and its benefits. They discuss the definition of HIIT, its physiological mechanisms, and how it compares to traditional exercise. The conversation also covers the implications of HIIT for different populations, its connection to VO2 max and longevity, practical applications in daily life, safety considerations, and resources for further learning.

00:00 - Introduction to High-Intensity Interval Training (HIIT)
04:39 - Physiological Mechanisms of HIIT vs. Traditional Exercise
08:34 - HIIT for Different Populations and Health Benefits
12:30 - VO2 Max and Longevity: The HIIT Connection
16:30 - Practical Applications of HIIT in Daily Life
20:37 - Safety and Considerations for HIIT Training
24:31 - Conclusion and Resources for Further Learning

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. Part 2 will drop next week as episode 26.

• 0:01:11 - Question about Continuous Glucose Monitoring and Repatha®
• 0:04:34 - Where is the glucose coming from in the morning?
• 0:07:07 - Blood Glucose Spike in the sauna
• 0:09:43 - Impact on blood sugar of the order of eating food
• 0:12:18 - Continuous Glucose Monitor App 
• 0:13:29 - A question about avoiding jet lag
• 0:13:26 - Minimizing Jet Lag and Melatonin
• 0:16:15 - Adjust your watch to the timezone you are going to be at
• 0:19:29 - Getting your brain acclimated to the new time 
• 0:22:30 - Warning about taking Melatonin
• 0:26:59 - A question about Vibration Plates and their benefits
• 0:27:23 - Vibration Plates and the claim of increasing Growth Hormones
• 0:32:39 - Back Pain and Vibrating Plates 
• 0:33:47 - What happened to Bronny James?
• 0:34:27 - Hypertrophic Cardiomyopathy
• 0:40:54 - Athletes and Heart Disorders

In this episode, Buck dives into the groundbreaking work of Dr. David Raubenheimer and Professor Stephen Simpson, renowned nutritional scientists from the University of Sydney. They unpack the "Geometric Framework for Nutrition," a holistic and visual approach that examines how nutrients interact to shape health and aging. From protein leverage to balancing macronutrients for longevity, this conversation challenges conventional calorie counting and offers profound insights into optimizing diet across the lifespan.

In this wholesome conversation, Buck and Dr. Ellen Langer discuss the profound connection between the mind and body, emphasizing the importance of mindfulness in health and aging. She shares insights from her groundbreaking studies, including the counterclockwise study, which demonstrated that altering one's mindset can lead to significant health improvements. The discussion also explores how perception influences physical attributes, the detrimental effects of mindlessness, and the potential for mindfulness to enhance longevity and overall well-being. 

00:00 - The Mind-Body Connection and Health Paradigms
06:08 - Perception and Health: The Power of Mindset
12:09 - Mindlessness: The Root of Our Problems
19:36 - Understanding Mindfulness
27:52 - The Power of Placebo
36:20 - Harnessing Mindfulness for Longevity

Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, as well as practical steps to minimize exposure to microplastics in daily life.

Buck welcomes Tina Sindher, a specialist in food allergy from Stanford University Medical Center to discuss the basics of food allergy.

Topics include root causes of food allergy, prevention, diagnosis, and treatment.

Show Notes:

04:33 Does where you live affect your allergies?

06:46 How do you know you have an allergy and not something else?

09:40 Life-threatening allergies explained

13:41 Does allergy develop from childhood?

16:28 What makes some foods trigger allergies?

20:22 Rising gluten sensitivity

23:03 Are restrictive food policies increasing cases of allergies

26:20 The relationship between eczema and allergy

29:00 Microbiome

32:43 Desensitizing allergies

Sapio with Buck Joffrey Episode 46 is part 1 of a 2 part episode with Dr. Tom Walters, DPT, OCS. Tom is a Doctor of Physical Therapy, former Kinesiology Professor, author of the bestselling book "Rehab Science: How to Overcome Pain and Heal From Injury". He is also an Instagram and YouTube creator with with more than 1.6 million combined followers, with a focus on "Alleviating Pain and Moving Better".

In part 1 of this 2 part episode Tom and Buck discuss excercise and the things you should be doing to help you live longer and stay healthier. Also discussed in detail is pain. These are both very important topics for overall quality of life and longevity. The things you do today will impact your overall well being for decades to come.

Don't miss part 2 (episode 47) which drops Wednesday.

Tom can be found on Instagram (@rehabscience) and YouTube. His book is available on Amazon, Barnes & Noble and Target. Find links to other resources including a free Injury Prevention Program at https://rehabscience.com/links/.

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

Link to Buck's Results:

https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing

 https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing

Section 1: Overview of Cholesterol Metabolism

• Cholesterol in the Body:
  • Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production.
  • It is produced endogenously in the liver and absorbed exogenously from dietary sources.
• Endogenous Production:
  • Cholesterol is synthesized in the liver through the mevalonate pathway.
  • Key intermediates: Lathosterol and Desmosterol, indicators of cholesterol production rate.
• Exogenous Absorption:
  • Dietary cholesterol is absorbed in the intestines along with plant sterols like Beta-sitosterol and Campesterol.
  • These sterols compete with cholesterol for absorption, reflecting dietary cholesterol absorption levels.

Section 2: Detailed Analysis of the Test Components

• Production Markers:
  • Lathosterol:
    • Precursor in the cholesterol biosynthesis pathway.
    • Elevated levels indicate increased hepatic cholesterol synthesis (overproduction).
    • Example: Lathosterol level of 329 µmol x 100/mmol in my study indicates hyperactive cholesterol production.
  • Desmosterol:
    • Another precursor in the synthesis pathway, contributing to total cholesterol production.
    • High levels reinforce the diagnosis of increased cholesterol production.
    • Example: Desmosterol level of 74 µmol x 100/mmol in my study supports elevated production.
• Absorption Markers:
  • Beta-sitosterol:
    • Plant sterol absorbed in the intestines, competes with cholesterol.
    • High levels suggest increased absorption of dietary cholesterol.
    • Example: Beta-sitosterol level of 120 µmol x 100/mmol indicates borderline absorption.
  • Campesterol:
    • Similar to Beta-sitosterol, reflects cholesterol absorption efficiency.
    • Elevated levels indicate increased absorption.
    • Example: Campesterol level of 113 µmol x 100/mmol within normal limits but suggests absorption could be a factor.
• Cholesterol Balance Score:
  • Ratio of production to absorption markers.
  • A higher score indicates predominant cholesterol production; a lower score indicates absorption as the main issue.
  • Example: Score of 2.4 suggests overproduction is the dominant issue.

Section 3: Clinical Implications and Treatment Strategies

• Frequency of Overproduction vs. Overabsorption:
  • Common to see patients with either overproduction or overabsorption, but less commonly both.
  • Overproducers: Significant portion of hypercholesterolemia patients, especially those with genetic conditions like Familial Hypercholesterolemia.
  • Overabsorbers: Often have high-cholesterol diets or genetic predispositions.
• Treatment Implications:
  • Overproducers: Statins are first-line treatment; they inhibit HMG-CoA reductase in cholesterol synthesis.
  • Overabsorbers: Ezetimibe, which inhibits intestinal cholesterol absorption, can be effective.
  • Combination Therapy: Considered for mixed dyslipidemia cases.
• Case Examples:
  • Example of a patient with high production markers but borderline absorption: Statin therapy may be appropriate, with potential addition of Ezetimibe.
  • Example of a patient who is a high absorber but not a high producer: Dietary changes and Ezetimibe might suffice without statins.

Section 4: Physiological Mechanisms and Genetic Considerations

• Pathophysiology of Cholesterol Production:
  • Overproduction may result from genetic mutations (LDL receptor or PCSK9) or conditions like insulin resistance.
• Pathophysiology of Cholesterol Absorption:
  • Increased absorption could be due to genetic polymorphisms (NPC1L1 gene), leading to higher dietary cholesterol absorption.

Section 5: Practical Application in Clinical Practice

• Incorporating the Test into Clinical Workflow:
  • Integrate the Boston Heart Cholesterol Balance Test for patients with unexplained hypercholesterolemia or non-responders to standard therapy.
  • Tailor treatment based on whether a patient is an overproducer, an over absorber, or both.
• Patient Communication:
  • Explain test results in an understandable way, emphasizing personalized treatment plans.

In this episode, Buck Joffrey discusses the importance of going beyond the normal scope of testing when it comes to lipid profiles and cardiovascular health management. He emphasizes the significance of understanding cholesterol particles, particularly APO-B, and lipoprotein(a), in assessing heart disease risk. He also highlights preventative strategies to optimize health and mitigate risks associated with cardiovascular disease.

In this episode Buck discusses snoring and sleep apnea and why they should be taken seriously.

• 0:01:17 - Snoring And Sleep Apnea
• 0:01:45 - Up To 20% Of The Population Has Clinically Relevant Sleep Apnea
• 0:02:52 - Central Sleep Apnea
• 0:03:12 - Obstructive Sleep Apnea
• 0:03:34 - Sleep Apnea Is The Enemy Deep Sleep
• 0:03:59 - Increased Risk Of Diseases Associated With Sleep Apnea
• 0:05:32 - Sleep Apnea Screening
• 0:05:56 - Epworth Sleepiness Scale https://epworthsleepinessscale.com/about-the-ess/
• 0:06:16 - Apnea/Hypopnea Index
• 0:06:44 - How to Treat Sleep Apnea
• 0:07:10 - CPAP Machine
• 0:07:32 - Mandibular Advancement Device
• 0:08:53 - Uvulopalatopharyngoplasty (UPPP)

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. This is Part 2. Listen to episode 24 to hear part 1.

• 00:01:31 - Question about taking naps to make up for not enough sleep
• 00:03:06 - REM Sleep and Deep Non-REM Sleep
• 00:11:54 - Shift work is very detrimental to to health
• 00:13:11 - Question about reversing aging in cells
• 00:13:29 - David Sinclair’s book Lifespan
• 00:15:30 - Stem cells and aging
• 00:17:22 - Genetically mutated rodents with Progeria and  the Yamanaka Factor
• 00:21:59 - Methylation and the Epigenome
• 00:22:37 - Biological clocks and changes in the Epigenome
• 00:23:20 - Sinclair’s study on using a drug cocktail to reverse the cellular aging patterns in aged human cells

In this conversation, Buck and Dr. Nicola Conlon delve into the significance of NAD (Nicotinamide Adenine Dinucleotide) in aging and longevity. Dr. Conlon explains the role of NAD in cellular energy production, its decline with age, and the consequences of this decline on cellular repair and overall health. They discuss the importance of NAD in activating sirtuins, which are crucial for longevity, and explore the limitations of direct NAD infusions. The conversation concludes with insights into NAD precursors like NMN and NR, which can help increase NAD levels in the body. 

Dr. Conlon is offering our listeners a special 20% discount on first purchase at www.nuchido.com. Use the code SAPIO20.

Shownotes:

• 0:01:04 Metformin and Diabetes
• 0:02:48 Metformin Monotherapy
• 0:06:46 Are There Any Geroprotective Benefits From Taking Metformin?
• 0:10:50 Benefits of Rapamycin and
• 0:12:14 Acarbose and Sugar Metabolism
• 0:16:28 SGL2 inhibitor Jardiance
• 0:20:37 Glucose Monitoring and Metformin

Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body’s nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there’s a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity.

Buck discusses Heart Rate Variability (HRV). What is it? Why does it matter and how can it effect your overall health in this mini Sapio with Buck Joffrey episode.

• 00:00:31 - Medicine 3.0: Taking medicine into your own hands
• 00:01:15 - What is Heart Rate Variability (HRV) anyway? 
• 00:02:16 - The Autonomic Nervous System
• 00:02:37 - The Parasympathetic Nervous System
• 00:03:32 - Lower Hrv Has Been Linked To An Increased Risk Of Cardiovascular Diseases
• 00:04:18 - Ways To Increase Your HRV

Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians.

01:18 HIV

05:26 Hepatitis

09:20 HPV

In this is a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. Part 2 will be online for our regular Wednesday episode drop.

• 0:00:39 - About Dr. Michael Mantz
• 0:02:47 - Studying With Famous Herbalists In Utah
• 0:06:46 - Dr. Mantz's Integrative Approach Combining Nutrition, Exercise And Supplements
• 0:08:21 - Dr. Mantz's Current Practice: The Santa Barbara Integrative Medicine
• 0:08:43 - Ketamine Assisted Psychotherapy
• 0:11:06 - What Are Psychedelics?
• 0:12:49 - Understanding Ketamine's Mechanism
• 00:14:47 - Ketamine As A Dissociative Anesthetic
• 00:16:38 - Effects Of Ketamine On GABA
• 0:17:53 - Ketamine Working On The Nmda Receptors
• 0:19:44 - NMDA Receptors And Expanding Consciousness 
• 0:22:23 - Augmenting Psychotherapy With Ketamine 
• 0:28:37 - Placebo Effect And Inflection Points
• 0:33:35 - Clinical Depression And Its Symptoms
• 0:35:18 - SIG-E-CAPS And Dysregulations Of Sleep
• 0:37:24 - Is Depression Physiological Or Psychological?
• 0:39:56 - The Impact Of Depression On Perception
• 0:40:10 - Understanding Depression And Medication Options
• 0:47:39 - Effectiveness Of SSRIS In Treatment
• 0:52:38 - Ketamine Therapy And Treating Depression
• 0:54:44 - Western Medicine's Relationship With Psychedelics
• 1:01:55 - Today's Opioid Epidemic
• 1:04:26 - Psychedelics In Mental Health

In this episode of Sapio with Buck Joffrey, Buck discusses the importance of setting clear goals and truly believing they can be achieved.

He emphasizes the need to honestly evaluate if one's current plans will achieve their goals, and make adjustments if needed.

Buck Joffrey, MD interviews Anoop Kumar, MD on his perspective on health and wellness. Dr. Kumar is an emergency medicine doctor who is also knowledgeable about traditional Indian Philosophy and medicine.

Show Notes:

00:43 Near-Death Experience and Shift in Perspective

07:04 The Three Minds Framework

23:03 Reevaluating the Model of Human Anatomy

27:20 The Four Engines: Nutrition, Movement, Connection, and Rest

39:24 The Four Engines of Health and Healing

41:01 Harnessing the Placebo Effect and Self-Healing

Buck provides ways to prevent getting deep venous thrombosis during long flights and drives. Deep Venous thrombosis refers to clots in the deep veins of the legs that can break free and cause a life threatening emergency called pulmonary embolism which represents blood clots in the arteries of the lungs. 

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet.

Show Notes: 

01:10 Types of Fasting

03:31 Why Fasting is Beneficial From a Cellular Level

07:00 Intermittent Fasting VS Fast Mimicking Diet

14:05 How Does Fasting Help Cancer Patients

20:37 What Is in the Fast Mimicking Diet

33:38 Pills and Supplements for Fasting Mimicking Diet

41:23 Time-Restricted Feeding Based on Circadian Rhythm

Buck Joffrey welcomes Dr. Michael Miller and Dr. Jacob Allen for an in-depth discussion on gut health and its vital role in overall well-being. They explore the gut microbiome’s composition, how diet and lifestyle influence its dynamic nature, and the significance of fermented foods and dietary bioactives. The conversation also tackles the controversial topic of leaky gut syndrome, common misconceptions about gut health, and the potential benefits of probiotics.

Dr. Allen and Dr. Miller further break down the complexities of leaky gut, its triggers, and the intricate relationship between stress, exercise, and the microbiome. They highlight the gut-brain axis, the critical role of dietary fiber, and the importance of a diverse diet rich in fiber and fermented foods to support gut integrity and long-term health.

Learn more about Dr. Allen and Dr. Miller: 

https://nutrsci.illinois.edu/directory/jmallen5

https://fshn.illinois.edu/directory/mille216

Questions? Send us a message:

https://www.longevityroadmap.com/

Follow us on social media:

https://linktr.ee/longevityroadmap

In our last episode of Sapio with Buck Joffrey, Neurologist Dr. John Foley took us through the diagnosis and pathophysiology behind Alzheimer’s disease

He also told us about the risk factors for getting Alzheimer’s disease—both avoidable and not. 

In this episode, we talk about what we can do to mitigate the risk of developing Alzheimer’s disease, even if you are genetically predisposed to it. We talk about everything from Saunas to supplements. We also take a look at the cutting-edge research and new therapies that might actually be able to treat Alzheimer’s disease that may be right around the corner.

Again, this is a must listen for anyone who wants to live a long healthy life with all of their cognitive abilities and memories intact. It is relevant to you and probably to someone in your family and I’m hopeful that by listening to this show, you will be able to come away with actionable information for you or your loved ones to play offense against this brutal disease.

By the way, if you want to see what Dr. Foley is up to with his neuro-optimization clinic, make sure to check out his website for cerepro bioscience at cereprobio.com

Buck discusses studies on the effect of saunas for overall health and longevity.

• 0:01:35 - What's The Big Deal With Saunas?
• 0:02:03 - Kuopio Ischemic Heart Disease Study
• 0:04:44 - Sauna Benefits For The Body
• 0:04:53 - Heat Shock Proteins
• 0:07:30 - Increased Expression Of Brain Derived Neurotrophic Factor
• 0:09:05 - Saunas And Longevity
• 0:11:08 - Blood Glucose Spikes While In The Sauna
• 0:12:19 - Optimal Timing For Sauna Usage

Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine as an anti-inflammatory treatment for coronary artery disease and atrial fibrillation.

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life

Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people’s health.

Show Notes:

01:35 Dr. Lufkin’s Personal Journey to Question the Medicine Establishment

04:14 When Did People Start to Take Metabolic Syndrome Seriously?

08:33 What Exactly is Metabolic Syndrome from a Physiological Standpoint?

10:21 The Balance Between Building and Breaking Down in the Metabolic System

14:41 Time-Restricted Feeding and Ketogenic Diet

28:31 The Role of Medications and Supplements

30:51 Lifestyle and Exercise as Intervention

Sapio with Buck Joffrey Episode 47 is part 2 of a 2 part episode with Dr. Tom Walters, DPT, OCS. Tom is a Doctor of Physical Therapy, former Kinesiology Professor, author of the bestselling book "Rehab Science: How to Overcome Pain and Heal From Injury". He is also an Instagram and YouTube creator with with more than 1.6 million combined followers, with a focus on "Alleviating Pain and Moving Better".

In part 2 of this 2 part episode Tom and Buck discuss supplements, sleep, pain and the things you should be doing to help you live longer and stay healthier.

Make sure to check out episode 46 as well to get the whole conversation.

Tom can be found on Instagram (@rehabscience) and YouTube. His book is available on Amazon, Barnes & Noble and Target. Find links to other resources including a free Injury Prevention Program at https://rehabscience.com/links/.

In this Sapio with Buck Joffrey episode Buck talks to Dr. Sean London from Prenuvo. A company revolutionizing healthcare with it's full body MRI scans. This is all about Medicine 3.0. Early detection is key in fighting many diseases including cancer for example. Buck recently had the procedure and Dr. London goes through some of the findings - one of which was a bit of a surprise.

In this episode of Sapio with Buck Joffrey, Buck discusses a new study out of Oxford that outlines 11 key risk factors for dementia. And the good news - while you can't change everything, many of these factors can be controlled buy modifying behaviors.

If your want to see more info on the study goto: https://www.psych.ox.ac.uk/news/new-dementia-risk-score-helps-identify-people-at-risk.

• 00:00:02 - The difference between Alzheimer's Disease and Dementia
• 00:01:02 - Diagnosing Alzheimer's disease
• 00:01:25 - Causes of Dementia
• 00:01:48 - Dementia risk factors and how to avoid them
• 00:03:08 - Parental Dementia
• 00:03:27 - APOE e4 as a risk factor for Alzheimer’s
• 00:04:44 - Dementia risk factors you can control

In this Sapio with Buck Joffrey Medical Update, Buck discusses new reasearch that connects hearing loss and dementia. If you or a loved one is suffering from hearing loss you are going to want to take action.

Could an essential fatty acid discovered in Navy dolphins unlock the secret to healthier aging? In this episode of Longevity Roadmap, Dr. Stephanie Venn-Watson reveals the groundbreaking science behind C15, an essential fatty acid linked to longevity and reduced disease risk. Learn how metabolomics uncovered the connection between higher C15 levels and healthier dolphins—and why this matters for humans.

Dr. Venn-Watson explains how C15 deficiency can accelerate aging, increase the risk of fatty liver disease, and contribute to cellular fragility syndrome and ferroptosis, a newly discovered form of cell death linked to iron overload. We dive into clinical trials on C15 supplementation, its impressive health benefits, and why this saturated fat may be a game-changer for nutrition and aging.

Discover why dolphin research is reshaping our understanding of essential fatty acids and why C15 could be the key to addressing the silent epidemic of C15 deficiency. Whether you're interested in longevity, epidemiological studies, or cutting-edge clinical trials, this episode offers actionable insights into the future of health and nutrition.

Curious to learn more? Grab Dr. Venn-Watson’s new book, The Longevity Nutrient: The Unexpected Fat That Holds the Key to Healthy Aging, and explore the groundbreaking science behind C15 and its potential to revolutionize your health: https://fatty15.com/

Ready to experience the benefits of C15 yourself? Dr. Venn-Watson is offering our audience an exclusive 20% off your first order at: fatty15.com/LONGEVITYROADMAP

Buck interviews Dr. Ken Frumkin on his own journey of aging and cognitive decline.

The exploration into the secrets of aging continues in this much-anticipated second part of our conversation with Dr. Joel Rothman from UCSB's Center for Aging and Longevity Studies (CALS).

Join Buck as they dive further into the fascinating breakthroughs that are setting the stage for a potential revolution in human longevity. Tune in to episode 33 for a straightforward, yet enlightening discussion on the future of aging.

• 00:00:53 - Understanding Mitochondria 
• 00:04:32 - Mitochondria and Aging
• 00:04:56 - Mitochondrial DNA
• 00:09:15 - Mitochondrial Dysfunction
• 0:09:48 - Removing Damaged Mitochondria
• 0:13:54 - Mitochondrial DNA and Aging
• 0:15:57 - Epigenetics and Aging
• 0:17:36 - Exploring Other Mechanisms Related To Longevity
• 0:19:08 - Understanding Stress Response
• 0:19:25 - Types of Stress
• 0:20:32 - Stress Response Systems in Cells
• 0:21:08 - Manipulating Stress Response
• 0:21:54 - Artificially Activating Stress Response
• 000:22:38 - Stress Response and Aging
• 00:23:43 - Hormesis and Longevity
• 00:24:32 - Heat and Cold Stress
• 00:25:29 - Interplay of Different Factors
• 00:26:07 - Studying Aging in Worms
• 00:26:28 - Debate on Aging Research
• 00:32:36 - Ethical Implications of Longevity Research
• 00:34:14 - Addressing Ethical Concerns
• 00:35:40 - Potential Issues with Extended Lifespan
• 00:38:18 - Longevity and Population Growth
• 00:39:28 - Ethical Considerations of Extending Lifespan
• 00:40:42 - Impact on Population Growth
• 00:42:02 - Predictions for Future Access to Technology

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment.

Show Notes:

00:58 What Really is Healthspan?

05:06 Biological Age VS Chronological Age

07:41 The Factors that Determine Biological Aging

12:08 What Happens When You Artificially Suppress These Factors

16:58 What is Phenomics and how can it predict diseases?

24:21 How Can You Do Self Tests?

In this episode, Buck discusses gene editing and its potential implications for human health and longevity. He explains the basics of gene editing, including the structure of DNA and how genes are transcribed into proteins, then dives into the history and development of gene editing techniques, focusing on the game-changing CRISPR-Cas9 technology. He also explores the practical applications of gene editing, such as its use in treating sickle cell anemia and other genetic diseases, as well as the potential for human longevity, including targeting genes associated with aging and reversing epigenetic age.

Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apolipoprotein B, and the future of pharmacotherapy in lipid management.

Buck interviews Dr. Corey Frucht, MD, PhD, a board-certified dermatologist on the topic of aging skin and skin cancer. This episode explores the causes of aging skin and skin cancer, as well as what we can do to combat the inevitable effects of skin aging.

Show Notes:

00:00:50:12 How and why can skin look young or old?

00:03:51:20 Why does the skin of people of color age slower?

00:05:14:09 How exactly does UV light damage your skin?

00:07:05:01 Sunscreen 101

00:11:41:08 Physical blockers vs chemical blockers

00:13:41:00 Can you get tan without damaging your skin?

00:14:16:06 How to keep your skin young

00:29:24:14 Skin Cancer

Shownotes:

• 1:02 What is Diagnostics when it comes to medicine?
• 2:35 What are some of the traditional Diagnostics used in Medicine 2.0?
• 4:11 - Summarize the basic screenings you should be getting starting at based on Medicine 2.0 guidelines
• 6:09 Why are PSA screenings controversial?
• 8:19 - Cardiovascular testing - medicine 2.0
• 8:53 - Medicine 3.0
• 9:26 What’s a Cardio IQ?
• 18:10 Genetic Screening
• 19:40 MTHFR Gene Mutation
• 21:58 APOE e3 and e4
• 23:00 ACTN Gene
• 24:06 Galleri® Test
• 27:27 Whole Body MRI
• 29.11 How difficult is it to get these tests?
• 32:07 Self Diagnostics and Medicine 3.0
• 32:53 Continuous Glucose Monitor
• 33:18 Medicine 3.0  and the variability between humans
• 38:13 Key Takeaways
• 43:51 Q&A
• 44:46 Cleery heart scan analysis

Topics include:

00:25 Protein Intake for Longevity

12:40 Tips to Improve Sleep Quality

22:52 Is Robert F. Kennedy Jr. Controlled by a Worm

Suicide rates are rising—and the impact on longevity is profound. In this eye-opening episode of Longevity Roadmap, Dr. Peter Franz dives deep into the intersection of mental health, suicide prevention, and lifespan. He explores why nearly 50% of Americans experience depression, how loneliness accelerates suicide risk, and why digital interventions offer new hope. We also unpack the demographics most at risk, the physiology behind depression and suicidal thoughts, and the critical role of reducing stigma around mental health. Dr. Franz offers practical insights for recognizing warning signs, improving treatment access, and understanding future strategies to personalize suicide prevention.

Learn more about Dr. Peter Franz:

https://www.yu.edu/faculty/pages/franz-peter

Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI.

Show Notes:

01:33 8 Hours Or Less Fasting Window = Higher Chance of Cardiovascular Disease?

04:58 Why the Study that Claimed the Correlation Was Wonky

08:02 Why There May Be Some Truth in the Studies

14:03 What to Do With Mixed Data and Opinions?

15:49 The Best Protein Intake?

22:32 Why Full Body MRI?

Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for in devices.

Buck reviews the physiology behind human growth, hormone in humans. He discusses normal growth hormone patterns as people age, pathologies and studies of people with both growth, hormone deficiencies and excess.

Buck also discusses the risks and benefits of human growth hormone supplementation in otherwise normal middle-aged adults.

In this bonus Q&A episode Buck Joffrey dives a little deaper into one of the key Episode 2 topics - blood glucose and how it affects your body with Sapio Executive Producer Ben Hyatt.

Shownotes:

• 0:01:36 Understanding Glucose and Insulin Interaction
• 0:06:19 Food Combinations and Blood Sugar
• 0:10:56 Understanding Diabetes and Glycation
• 0:16:13 Diabetes and Testing

Buck introduces his brand new podcast, Longevity Junky.

In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of brain health in overall longevity.

In this Sapio Short Buck discusses the news last week that the World Health Organization (WHO) has declared the artificial sweetener Aspartame a "a possible carcinogen". So what does this classification mean for you and how worried should you be?

• 0:00:13 - World Health Organization classified aspartame as a possible carcinogenic substance
• 0:02:03 - Group 2B - the possibly carcinogenic to humans category
• 0:03:18 - WHO concedes that the upper limit for safe daily consumption of aspartame is equivalent to drinking 9 to 14 cans of Diet Coke per day for the average 150 lb. person.
• 0:04:10 - Consider another sweetener like Splenda or Stevia

In this can't-miss episode, Buck engages in a riveting conversation with the Dr. Joel Rothman, the Founding Director at UCSB's Center for Aging and Longevity Studies (CALS). Prepare to be transported into the cutting-edge world of scientific discoveries that are reshaping our understanding of aging, potentially unlocking the secrets to unprecedented human longevity. 

This is only the beginning! Be sure to catch the continuation of this talk in episode 33, where we delve even deeper into the groundbreaking breakthroughs at the frontier of aging research including the research being done at CALS.

• 00:02:24 - The Science of Aging: A Deeper Dive
• 00:04:34 - The Human Lifespan
• 00:07:04 - The Different Lifespans of Organisms
• 00:09:12 - Aubrey de Grey Longevity Escape Velocity
• 00:12:27 - The Brain and Aging
• 00:13:47 - David Sinclair’s Book Lifespan
• 00:14:23 - The Role of Epigenome in Aging
• 00:19:10 - Genes and Epigenome
• 00:20:41 - DNA Methylation and Chromosome Structure
• 00:22:02 - Information Theory of Aging
• 00:24:14 - Proteostasis or removal of defective proteins
• 00:26:17 - The Horvath Clock and Biological Clocks
• 00:30:50 - Epigenome Reset
• 00:33:53 - Yamanaka Factors 
• 00:37:00 - Extending Healthspan through Cocktails
• 00:41:44 - Challenges in Drug Development

Buck Joffrey, MD welcomes pharmacist and glutathione expert Dr. Nayan Patel. This podcast discusses the role of glutathione as an antioxidant including why it is known as the "master" antioxidant. The discussion reviews the physiology of glutathione in the body focussing on disease prevention and also discusses different mechanisms of supplementation.

Show Notes:

00:48 What is oxidative stress?

04:12 What is an antioxidant and how does it work? 

10:24 Glutathione and its relationship to longevity

29:12 Dr. Patel’s Auro Wellness

In part 2 of this 2 part episode Buck discusses male sexual health with Justin Houman, MD from Tower Urology in Los Angeles. Over half of American men over the age of 40 suffer from erectile dysfunction and other sexual disorders. 

• 00:00:42 - Male Refractory Period
• 00:01:44 - Erections are going to be weaker as you age
• 00:02:15 - Medication like Phosphodiesterase that help lower one’s refractory period
• 00:02:50 - Hormone called Prolactin that can cause increased refractory time
• 00:07:36 - Dealing with Premature Ejaculation
• 00:10:24 - Paxil and Tramadol For Premature Ejaculation
• 00:12:10 - Prostate issues
• 00:12:37 - Benefits of Cialis and Flomax
• 00:14:49 - Testosterone Replacement
• 00:16:17 - Clomid for Hypogonadism and Low Testosterone
• 00:18:31 - Human Chorionic Gonadotropin (hCG)
• 00:24:08 - Preserving Fertility
• 00:26:39 - Testosterone Blood Testing
• 00:27:44 - Masturbation Effects on Testosterone Levels
• 00:30:30 - Supplements like Tongkat Ali and Fadogia Agrestis

Buck talks about the common cold. He discusses the etiology, the role of cold weather, prevention and treatment of this common and frustrating problem.

Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and everyday activities. Mindfulness meditation can help access flow by improving focus and attention. The book 'Experiencing Flow' explores the relationship between mindfulness and flow and provides practical strategies for accessing flow in daily life.

00:13 The Definition of Flow

04:05 How Do We Have Flow?

08:25 Gettign In and Out of Flow

14:07 Mindfulness vs Flow   

Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase!

Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into the biology of skin aging, the impact of senescent cells, and the cutting-edge strategies OneSkin is using to combat age-related skin conditions. The conversation also explores clinical trials, product efficacy, and the broader systemic benefits of optimizing skin health.

Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0

Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Buck interviews Mark Mortenson and Rob Etherington from Clene Nanomedicine, discussing their innovative approach to treating neurodegenerative diseases using clean surface nanocrystals. They delve into the science behind nanoparticles, their role in enhancing mitochondrial function, and the mechanisms of neurorepair. They also cover clinical applications, safety considerations, and the challenges in bringing their nanomedicine to market. 

Planning a trip? Jet lag can be a serious impediment to making the most of it. Buck discusses jet lag; what it is and strategies to beat it including the use of Melatonin.

• 00:00:25 - Desynchronosis - Disruption To Your Circadian Rhythm
• 00:01:05 - Melatonin
• 00:02:39 - Bright Light Exposure Is Really Important To Resetting Your Circadian Clock
• 00:04:48 - Some Negative Effects Of Chronic Melatonin Use

Shownotes:

• 0:01:31 The Importance Of Sleep For Health
• 0:03:41 Rapid Eye Movement (REM) Sleep
• 0:03:57 Non-REM Sleep
• 0:06:22 Sleep Problems and Links to Alzheimer's and Dementia
• 0:08:14 Glial–Lymph and Deep Sleep
• 0:10:14 REM Sleep And Brain Health
• 0:14:28 Sleep Apnea: Berlin questionnaire and STOP-Bang assessment
• 0:17:04 Oura Ring
• 0:17:57 Sleep Disruption and Cancer
• 0:23:26 Night Shift Work And Health Risks
• 0:24:28 Suprachiasmatic Nucleus (SCN) and the Sleepway Cycle
• 0:26:35 Sleep And Longevity
• 0:33:20 Improving Sleep Quality: Blue Light Avoidance
• 0:35:25 Adenosine and Caffeine
• 0:35:47 Improving Sleep Quality And Habits
•  

Hey Sapio Fans,

I’ve got something really exciting for you today—a chance to win a full-body MRI worth $2,500!

This giveaway comes from my new podcast, Longevity Junky (that’s junky with a Y). It’s a fun, insightful show I co-host with actress Nikki Leigh, where we dive into cutting-edge advancements in health and longevity.

This week’s episode is all about full-body MRIs from Prenuvo, a groundbreaking technology that can identify over 500 conditions—including deadly cancers and brain aneurysms—before they pose a serious threat to your health.

Here’s how you can enter to win this $2,500 Prenuvo MRI scan for free:

1. Go to Apple Podcasts and find the Longevity Junky podcast (that's "Junky" with a Y).
2. Leave a five-star review for the podcast.
3. Subscribe to the podcast.
4. Take a screenshot of your review.
5. Visit LongevityJunky.com (again, "Junky" with a Y).
6. Send the screenshot of your review along with a brief explanation of why you’d like a full-body MRI.

Winners will be announced in 2 weeks—stay tuned and good luck to everyone!

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

Buck discusses with Executive Producer Ben Hyatt a study that appeared June 9th, 2023 in Science magazine that linked Taurine with healthy aging and increased lifespan in animal studies. 

• 0:01:30 What we knew about Taurine before the study.
• 0:03:22 What is Taurine?
• 0:03:39 What new information did we learn from the study?
• 0:06:30 Why do multiple models matter when it comes to studies?
• 0:07:04 What is the mechanism between improvements in health span and longevity?
• 0:07:30 Cellular Senescence - what is it and why does it matter?
• 0:09:00 DNA damage in aging.
• 0:10:30 Connecting the dots between low taurine levels and poor health.
• 0:11:10 Steps Buck is taking since reading the study.

🎧 New Episode of Sapio with Buck Joffrey: The world is buzzing about the benefits of cold therapy, but is it all it's cracked up to be? 🧊 Buck delves deep into the icy waters of this wellness trend, separating fact from fiction and exploring whether the chills are worth the hype. Tune in for an eye-opening discussion and decide for yourself!

👍 Like, share, and let us know your thoughts on cold therapy! #SapioPodcast #BuckJoffreyInsights #ColdTherapyTruths #WellnessDebunked #HealthySkepticism #WellnessTrends #FactOrFiction #HealthMyths

Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer’s Disease.

Show Notes:

03:08 Why the Keto Diet?

04:15 How Does the Keto Diet Help You Lose Weight?

05:51 Other Benefits of the Keto Diet

09:14 How Does High Blood Sugar Result in Insulin Resistance?

11:44 What Defines a Keto Diet

16:13 Lifestyle VS Intervention

19:02 The Concern with High Cholesterol with the Keto Diet

24:11 Treating Alzheimer’s with the Keto Diet

Buck discusses his new book, Living Longer for Busy People in a question/answer session with producer, Ben Hyatt.

In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies.

00:00 - Introduction to Longevity Roadmap

03:08 - Case Study: A 70-Year-Old Patient's Health

12:07 - Understanding Lipid Management and Atherosclerosis

19:49 - Genetic Factors in Alzheimer's Risk and Lipid Management

In this episode, Alan Viglione, MD joins Buck to answer some of our audience questions.

• 0:01:08 - How To Prevent The Dawn Phenomenon Or Rise Of Sugar Levels During Sleep Or Early Morning
• 0:04:44 - Hemoglobin A1C
• 0:08:00 - What Is Gluconeogenesis? 
• 0:14:24 - Managing Dawn Phenomenon 
• 0:18:04 - A Question About Geroprotectant Supplements
• 0:19:37 - Nicotinamide Riboside As A Precursor to NAD+
• 0:26:02 - What Is A Senolytic?
• 0:29:29 - Benefits Of Senolytics
• 0:30:27 - Promising Potential Of Quercetin
• 0:32:30 - Genova NutrEval Test
• 0:34:11 - The MTHFR Gene Mutation 
• 0:41:56 - A Question About The Kirk Cousins Era With The Minnesota Vikings
• 0:44:10 - Cholesterol Management For Women 
• 0:54:27 - A Question About Helpful Daily Supplements And How To Tell Which Supplement Companies Are The True Good Guys
• 0:59:12 - Vitamin D Deficiency And Supplementation 
• 1:01:31 - Discussion On Vitamins, Supplements, And Sleep

In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics.

• 0:00:29 - What Is Psilocybin?
• 0:01:42 - The Serotonergic Effects Of Psilocybin 
• 0:04:08 - Exploring The Effects Of Microdosing Psilocybin
• 0:09:16 - Microdosing And Euphoria
• 0:12:03 - Exploring Psychedelic Microdosing
• 0:15:31 - The Fadiman Protocol
• 0:17:10 - The Stamets Protocol
• 0:19:59 - Microdosing Ketamine And Serotonergic Function 

Buck Joffrey, M.D. discusses metabolic syndrome which affects 1/4 of the global adult population and how it underlies the development of virtually every other major cause of death.

Show Notes:

00:13 Understanding Metabolic Syndrome

05:29 Criterias of Metabolic Syndrome

23:40: Insulin Resistance and Hyperinsulinemia

24:49: Metabolic Syndrome and Diabetes

37:49: Recommended Lab Tests

42:05: The Health Implications of Liposuction

50:42: The Importance of HSCRP

Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets.

Show Notes:

02:14 The definition of stress

13:16 Why does stress disrupt circadian rhythms and sleep

16:08 How do we treat stress?

21:23 Nootropics

24:39 Vagal nerve stimulator

28:34 Digital detox and meditation

33:02 Diet for stress

Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism.

Also included is a discussion on the role of human pheromones and attraction.

Show Notes:

01:20 Facial Attraction & Cues

08:30 Facial Symmetry

11:12 The Averageness of Facial Features

13:59 Clear and Unblemished Skin

15:44 Sexual Dimorphic Traits

22:23 Smell and Pheromone

Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each. 

Buck Joffrey interviews Professor Andrea B. Maier, a leading expert in geroscience and healthy aging. They discuss the evolution of longevity research, the importance of distinguishing between lifespan and healthspan, and the biological mechanisms of aging. Professor Maier emphasizes the need for precision medicine in interventions and the challenges of supplement quality. They also explore future technologies in longevity research, practical steps for individuals to assess their biological age, and the significance of guidelines in healthy longevity medicine.

Learn more about Professor Andrea Maier:

https://discovery.nus.edu.sg/19564-andrea-britta-maier

In this Sapio with Buck Joffrey Episode Short, Buck discusses Biological Age and how it is different than Chronological Age. Which of the two should be the true measure of a person's age?

This Black Friday and Cyber Monday, I want to share something truly meaningful—the opportunity to invest in your health or the health of someone you love.

The Longevity Roadmap Course has already transformed lives, uncovering critical health issues and empowering participants to reverse conditions like borderline diabetes and optimize their health. It’s no exaggeration to say this course has already saved years of good-quality life.

This year, why not give the ultimate gift—the gift of health and time? Imagine helping a loved one discover a brighter, healthier future with a life-changing resource tailored to empower them for decades to come.

Black Friday & Cyber Monday Special: For a limited time, I’m offering 20% off the Longevity Roadmap Course, which includes three months of biweekly one-on-one coaching with me. This offer is good through Cyber Monday, so don’t wait—act now!

The tools, science, and coaching included in this course can:

• Help prevent or reverse common conditions like heart disease and diabetes.
• Unlock strategies to add years of vibrant, good-quality life.
• Give peace of mind knowing you or your loved one is on the best path forward.

This isn’t just an investment in health—it’s an investment in time with the people who matter most.

Make this holiday season truly unforgettable by giving a gift that will last a lifetime—or longer.

Sign Up Now and Use the Coupon Code Blackfriday2024 at Checkout to Get 20% Off – Offer Ends Cyber Monday!

Here’s to a longer, healthier, and happier future—for you and your loved ones.

– Buck

P.S. Want to learn more? Book a call with me on longevityroadmap.com and let's talk!

In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal.

• 0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life
• 0:03:33 - Average Age When Women Experience Menopause And Perimenopause
• 0:06:51 - Pharmaceuticals Developed To Address Menopausal Symptoms In Women: Premarin And Provera
• 0:13:47 - Benefits Of Hormone Replacement Therapy
• 0:17:12 - Understanding Perimenopause And Testosterone Decline In Women
• 0:22:55 - The Secret Female Hormone: How Testosterone Replacement Can Change Your Life By Dr. Kathy C. Maupin
• 0:23:57 - Hormone Pellet Replacement For Women
• 0:25:02 - Side Effects Of Testosterone Replacement In Women
• 0:27:09 - Benefits Of Testosterone Replacement In Women
• 0:30:57 - Acoustic Wave Therapy For Women

Buck discusses the concept of longevity clinics with the CEO of Humanaut.

Show Notes:

03:53 What Does Humanaut Do?

06:07 The Team Behind Humanaut

14:49 How Does the Program Work?

An interview with Aubrey de Grey, a founding father of the longevity movement—the man who coined the phrase 'Longevity Escape Velocity.' Aubrey discusses the transformative potential of damage repair, stem cell therapies, and advancements that are turning science fiction into reality. From reversing cellular damage to extending health spans by decades, this conversation unpacks his cutting-edge research and bold predictions shaping the longevity landscape. Tune in to explore a future where living to 1000 might just be possible.

Buck talks with GRAIL President Josh Ofman, MD, MSHS, about their groundbreaking Multi-cancer early detection (MCED) technology and it's promise as a significant new tool in the war on cancer.

• 0:00:00 - Advancements in Cancer Detection Technology
• 0:00:35 - GRAIL Galleri test
• 0:02:11 - About Dr. Josh Ofman
• 0:05:14 - Cancer really is a disease of the genome
• 0:12:35 - Various guidelines for early detection of certain cancers
• 0:16:45 - Cancer Detection in Blood Biology
• 0:19:03 - Cell-Free DNA
• 0:23:38 - How many cancers is the GRAIL Galleri test able to detect? 
• 0:27:10 - How accurate is the GRAIL Galleri test?
• 0:31:49 - Limitations of the GRAIL Galleri test
• 0:36:18 - Why would oncologists be against this test?
• 0:40:57 - What happens after one gets a a "cancer signal detected" result?
• 0:45:13 - GRAIL Galleri test's Impact on Cancer Screening
• 0:48:42 - The cost of the GRAIL Galleri test

This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their association with atherosclerosis. Buck also discusses the significance of apolipoprotein B (APO-B) in measuring the risk of cardiovascular disease. He explains how APO-B can penetrate the blood vessel wall and trigger an immune response, leading to the formation of plaque and potential heart attacks. Buck recommends keeping APO-B levels below 60 milligrams per deciliter to reduce the risk of atherosclerosis. He also mentions the importance of testing for lipoprotein little A (Lp(a)) levels, as high levels of Lp(a) are a major risk factor for atherosclerotic cardiovascular disease.