Intelligent Medicine (Dr. Ronald Hoffman)

• Is the US diet deadly?
• Why do I always have a fast pulse? It ranges between 85-110
• I took Candibactin BR and AR with great success. Where do I go from here--a maintenance dose?

Dr. Hoffman continues his conversation with ObGyn Dr. Anna Cabeca, author of "MenuPause: Five Unique Eating Plans to Break Through Your Weight Loss Plateau and Improve Mood, Sleep, and Hot Flashes." 

Headlines are sounding alarms over the widespread use of melatonin—especially as a sleep aid for young kids. Dr. Deanna Minich has authored a comprehensive review of melatonin, in which she likens it to vitamin D in its potential utility for a variety of ailments—not just for insomnia and jet lag, but also for metabolic syndrome and diabetes, cancer, cardiovascular disease, brain disorders, autoimmune conditions, eye problems, tinnitus, PCOS, endometriosis, infertility, viral infections, and even ADHD and autism. Additionally, melatonin may confer anti-aging benefits. She affirms its overall safety, but cautions that some formulations are sketchy and may contain contaminants or vastly exceed or undershoot their claimed melatonin content. She discusses how modern life, with its ever-present artificial light, shift work, and travel across time zones may disrupt our circadian rhythms and put us in a state of darkness deprivation, with consequent melatonin depletion. For many conditions less is more, and use in children should be limited to special cases. Dr. Minich also emphasizes that lifestyle factors like properly timed light and darkness exposure, blue blocker glasses and screen apps, exercise and diet are cornerstones to optimal melatonin production, with melatonin supplements constituting only part of a holistic approach.

2024–a year in review (America’s worsening health picture); Obesity and cancer incidence rise in U.S. while healthspan declines; First-of-its-kind lawsuit takes aim at ultra-processed food makers; Nutritional support for childhood developmental disorders; Dr. Mark Hyman, integrative pioneer, gets the New York Times treatment; Can a blood pressure medication cause canker sores? Curbing Omega-6s, boosting Omega-3s, improves prostate cancer outcomes. 

Self-professed “psychonaut” Matt Zemon discusses his book “Psychedelics for Everyone: A Beginner’s Guide to these Powerful Medicines for Anxiety, Depression, Addiction, PTSD, and Expanding Consciousness." Removing the stigma around psychedelics—emerging science is demonstrating their utility for a variety of psychiatric conditions. Psilocybin, ayahuasca, ketamine, ibogaine, peyote and others are regaining currency among innovative health professionals. Zemon describes how these might work—by opening new avenues of consciousness and rejiggering neurotransmitters. We discuss safety and optimal guidelines for use. Unfortunately, prescribing is limited by draconian and antiquated drug laws. Zemon maintains what’s needed are legal avenues for obtaining properly regulated medications delivered in ideal settings. 

• Report: US will trail other nations in life expectancy by 2030
• Obesity rates a contributing factor to decreased life expectancy in the US
• What are your views about the use of AMPK? 

Dr. Ronald Hoffman and Nutritionist Leyla Muedin continue their reveal of the supplements they personally take.

Dr. Michael Karlfeldt offers a deep dive into integrative oncology and the importance of immune support, especially during the winter season. he delves deep into the immune-protective benefits of fermented wheat germ extract and AHCC, which combine in ImmPower PLUS to offer comprehensive immune enhancement, cancer prevention, and treatment support. The discussion highlights the role of natural killer cell activity, the Warburg effect, and the adaptogenic properties of these supplements in addressing both cancer and general immune health. Practical dosing recommendations and Dr. Karlfeldt's insights into the integration of conventional and alternative therapies provide valuable knowledge on how to bolster immune systems effectively.

• Update on another supplement: Maca
• A book recommendation: "The Anxious Generation"
• A comment from a listener about Trump's nomination for Surgeon General
• Hasn't the vaccine/autism link been thoroughly debunked?
• How much Mitopure should I take to help increase muscle mass?

Nutritionist Leyla Muedin discusses intermittent fasting, specifically addressing whether skipping morning coffee affects metabolism. She explains different approaches to intermittent fasting, including Bulletproof Coffee and time-restricted eating (TRE). Leyla also delves into a study on the effectiveness of TRE in weight loss and cardiometabolic health, highlighting that eating within a specific time window (7am-3pm) led to greater weight loss and improved mood compared to a broader eating period. She emphasizes the importance of a minimum nightly fast of 12 hours for autophagy and overall health benefits.

• Do I have to replace minerals when using a reverse osmosis water purifier?
• Is anyone tracking whether vaccinated or unvaccinated people are getting long covid?
• What supplements should not be taken with low-dose aspirin?;
• Can you talk about chelation therapy and cardiovascular disease?
• I want to get the right lamp for Seasonal Affective Disorder.  What do you recommend? 

Borrowing from tobacco industry litigation, law firm launches major suit against ultra-processed food conglomerates; Big Food employs same tactics as cigarette makers once did to delegitimize, intimidate critics; Are parasites the hidden culprit in cancer? Beers contain detectable levels of pesticides—as new evidence links glyphosate to neurodegenerative diseases; For some breast cancers, weight loss drugs may interfere with chemo efficacy; How to lower C-reactive protein? Ultra-processed foods contribute to psoriasis severity. 

Dr. Hoffman continues his conversation with Dr. Deanna Minich who authored a comprehensive review of melatonin.

The tricky business of boosting vitamin D; New doubts over prospect of extending lifespan to 150; Reduced sitting time found to curb back pain; GSK settles Zantac lawsuits for $2.2 billion; Incorrect arm position may lead to false elevation in blood pressure readings. 

US dementia cases set to double by 2060; Study claims red meat a culprit in cognitive decline—but a close read reveals it’s a lot of baloney; Aerobic exercise is best hedge against Alzheimer’s; Prevagen ordered to drop memory claims; When a blood pressure cuff is too tight, can it throw off readings? An 80-year-old who takes DHEA wants to add pregnenolone; Oregon hospital patient awarded $900,000 after face catches fire during surgery; LA residents may suffer health consequences of pollutants long after wildfires quenched. 

• Imprecision Nutrition? Intraindividual variability of glucose responses
• A comment on RFK Jr's proposed plans
• My lower vitamin D level requires a higher dose of insulin.  What gives?

Rethinking fluoridation; Riboflavin improves cognitive performance in older adults; Podiatrists highlight foot problems associated with Crocs; Mom’s pregnancy diet impacts brain size, intelligence of offspring; This year’s flu shot underperforms (why I’m a flu shot agnostic); Are there alternatives to Eloquis? 

• What is your take on DMSO?
• I'm taking Zetia and Crestor and have familial hypercholesterolemia. Can I eat saturated fat?
• I think I have demodex mite infestation. My doctor says almost everyone has it and they don't cause issues. What say you?
• Why do I have to stop taking my supplements before hip replacement surgery?

 

Dr. Hoffman continues his conversation with Matt Zemon, author of “Psychedelics for Everyone: A Beginner’s Guide to these Powerful Medicines for Anxiety, Depression, Addiction, PTSD, and Expanding Consciousness." 

• What dosage of Nicotinamide Riboside is optimal in increasing mitochondrial biogenesis?
• I've been treated for SIBO in the past but haven't yet tried rifaximin. Do you recommend it?
• Is the choline in eggs causing thousands of people to suddenly form blood clots?
• Is the EBCT still the most accurate, least-radiation-exposure test for coronary calcification?
• How many milligrams of SAMe do you recommend for depression? 

Commemorating 38th year of Intelligent Medicine; A pricey prostate drug advertised on football games may extend life for mere months without promise of cure; You dutifully threw out your “toxic” black plastic spatulas—was it faulty math? Air pollution robs marathoners of record times—and may be responsible for deaths of millions; Indian man, declared dead, taken to hospital after awakening on funeral pyre. 

• Save our supplements!
• My dermatologist told me to moisturize my rash with Crisco! Isn't that hydrogenated?
• Are there natural ways to treat eczema and psoriasis?
• Can I stop taking statins or do I have to wean myself off?
• Is there a natural way to treat hyperparathyroidism?
• My friend just told me to stop taking vitamin D because it's toxic. What say you? 

Dr. Hoffman continues his conversation with Lex Pelger, Scientist at CV Sciences, makers of the new +PlusHLTH line of non-CBD supplements that have similar effects on the endocannabinoid system. 

Guest Dr. Stephen Hussey, a chiropractor and functional medicine practitioner, discusses the importance and impact of a metabolic revolution. Dr. Hussey shares his personal journey of overcoming inflammatory conditions and managing type 1 diabetes through lifestyle changes, focusing on diet and functional medicine principles. The discussion highlights the flaws in conventional medical approaches to chronic diseases and the need for a holistic view of health. Emphasizing the benefits of a low-carb diet and the potential detrimental effects of excessive insulin, the episode explores the benefits of metabolic flexibility. The conversation also introduces the initiative MetabolicRevolution.org, which aims to demand better health guidelines from government agencies, urging a focus on research-based recommendations and reducing industry influence. Dr. Hussey's insights underscore the potential for personal health transformations and advocate for systemic changes to improve public health.

• Highlights from Dr. Hoffman's trip to Lithuania
• Is there a brand of Boswellia you recommend?
• I would like to start cooking with coconut oil. What do you recommend?
• What is the guide to taking strontium for bone health safely?
• Should I get the Shingrix vaccines after 4 covid shots and the annual flu shot?
• I've always had my T3 and T4 checked for my thyroid but never T2. How does it work? 

Dr. Hoffman continues his conversation with Dr. Stephen Hussey MS, DC, from MetabolicRevolution.org. 

The cholesterol conundrum: Nutritionist Leyla Muedin discusses recent research suggesting that HDL, or 'good' cholesterol, may protect against brain atrophy and dementia. The study from UT Southwestern Medical Center, published in the Journal of Clinical Medicine, found that higher concentrations of small particle HDL are linked to better cognitive function and greater gray matter volume. Leyla emphasizes the importance of understanding cholesterol's role beyond just heart health and challenges common misconceptions. She also highlights the benefits of dietary fats and criticizes outdated medical advice that promotes low-fat diets. This episode encourages a more nuanced view of cholesterol and its significant impact on overall health.

Menopause can pose severe challenges to women: hot flashes, cognitive impairment, sleep problems, and sexual difficulties, often compounded by weight gain. ObGyn Dr. Anna Cabeca is schooled in mainstream medicine but has added a natural medicine repertoire to her practice. She recounts how she learned to overcome her own devastating symptoms of early menopause. She believes that diets need to be individualized for menopausal women. Find her quiz to determine your menopause type at www.DrAnna.com/mpquiz. We discuss the role of supplements and bio-identical hormone replacement to augment tailored diets. Her book, "MenuPause: Five Unique Eating Plans to Break Through Your Weight Loss Plateau and Improve Mood, Sleep, and Hot Flashes," highlights the role variations on the keto diet and intermittent fasting can play in alleviating menopause symptoms and reversing mid-life weight gain. 

Dr. Hoffman continues his conversation with Nicola Twilley, author of author of “Frostbite: How Refrigeration Changed Our Food, Our Planet, and Ourselves.” 

In this special New Year's edition Q&A Dr. Ronald Hoffman and Nutritionist Leyla Muedin share their personal supplement regimens for 2025. They discuss the variety of supplements they take, including multivitamins, specific minerals, omega-3s, anti-inflammatories, probiotics, and immune-supportive nutrients. They also emphasize the importance of personalized nutrition and caution listeners against directly mirroring their supplement routines. The episode includes advice on seasonal adjustments to supplementation, the benefits of different nutrient combinations, and general tips for maintaining a balanced approach to supplement intake. Dr. Hoffman and Leyla also touch on their personal health goals and the rationale behind their choices, offering listeners insights into optimizing their own supplement strategies.

The Impact of Refrigeration on Food, Health, and the Planet: Nicola Twilley, author of “Frostbite: How Refrigeration Changed Our Food, Our Planet, and Ourselves,” details the historical development of refrigeration, its profound impact on food preservation, diets, and urbanization. The conversation also covers the technological and environmental challenges posed by refrigeration, alternative food preservation methods, and the consequences for small farmers and the global food system. Nicola also shares insights into the health implications of refrigeration and the innovative solutions being explored to reduce its environmental footprint.

Natural Health Advocacy and the impact of the recent political changes in the U.S.: Dr. Rob Verkerk, Executive & Scientific Director Alliance for Natural Health International & Alliance for Natural Health USA, shares insights into the significance of RFK Jr.'s potential appointment and its implications for natural health advocacy. They explore RFK Jr.'s unique trajectory, from environmental activism to becoming a controversial political figure, and discuss the challenges and opportunities his nomination presents. The conversation also touches on the FDA's regulatory overreach, the limitations placed on the natural health industry, and ongoing efforts to promote health freedom and natural health practices. Dr. Verkerk emphasizes the importance of scientific discourse, the role of social and environmental determinants of health, and the need for a balanced approach in integrating technology and natural health solutions.

Dr. Hoffman continues his conversation with Dr. Anurag Singh Chief Medical Officer at <u><a href="https://www.timeline.com/partners/dr-hoffman" target="_blank">Timeline Nutrition</a></u>. 

Harnessing Yoga's Potential in Neuro Rehabilitation and the Gut-Brain Connection: Nutritionist Leyla Muedin discusses a pilot study from Germany highlighting the benefits of integrating yoga into inpatient neuro rehabilitation for conditions like multiple sclerosis and stroke. The study shows significant improvements in pain, spasticity, anxiety, and overall quality of life. Additionally, Leyla explores the expanding research on the gut-brain axis, revealing how a healthy gut microbiome influences mental resilience and stress response. She emphasizes the importance of addressing both physiological and psychological factors to manage anxiety and improve mental health.

When hemoglobin A1c is inconsistent with fingerstick glucoses; A landmark study demonstrates improved muscle strength with urolithin A; Healthy diet can tamp down chronic pain; A mysterious new toxic compound detected in chlorinated water supplies; Long-term antibiotic use hikes risk for rheumatoid arthritis; Omega-3 scores vs. heart failure; Vegetarians consume more processed foods than those who consume meat; Best diet for prostate cancer. 

Dr. Hoffman continues his conversation with Dr. Dana Cohen, Integrative Medical Doctor and co-author of “Fuel Up: Harness the Power of Your Blender and ‘Cheat’ Your Way to Good Health.” 

• I've been taking Nexium for the last 20 years. Is this contributing to lower bone mineral density?
• Should my 83-year-old wife take more calcium for her osteopenia?
• What is your knowledge of Prolia? What are the side effects?
• I have mitral annular disjunction (MAD). Can you advise me?
• What can I take for my post nasal drip?
• Are there other blood thinners I can take where I don't need to check my INR?

New study says wine is good for heart after all—but should we drink more? How alcohol increases aggression by raising pain thresholds; Removing plastic chemicals can boost IQ, avert deaths, and save the world’s economy billions; Uterine thickening may be a prelude to endometrial cancer—can it be reversed? NIH study of green tea suggests it can; A new diagnosis of Sjögren’s syndrome has a caller spooked; Is the Internet making us dumber? Vitamin D in pregnancy gives kids stronger bones, but strikes out for diabetes prevention in healthy seniors; Dietary—but not supplemental—vitamin C curbs metabolic syndrome. 

The Importance of Posture and Core Strength for Health: Nutritionist Leyla Muedin discusses the critical role of posture and core strength in overall health and well-being. She provides practical advice on improving posture, from standing and sitting techniques to exercises like planks and balance-focused activities such as yoga and Tai Chi. Leyla emphasizes the impact of good posture on physical comfort, mobility, and even mental well-being. Additionally, she offers tips for setting up an ergonomic workspace and highlights the importance of taking breaks to minimize strain and promote better circulation. The episode underscores the significant benefits of incorporating intentional posture improvements and core-strengthening exercises into daily routines.

Foods and Lifestyle Changes to Manage High Blood Pressure: Nutritionist Leyla Muedin discusses effective ways to manage high blood pressure through simple lifestyle changes and dietary choices. She highlights the importance of achieving a healthy weight and outlines how foods like beets, celery, pistachios, asparagus, sweet potatoes, and salmon can support healthy blood pressure levels. Leyla also emphasizes the need to avoid processed foods, excess sodium, and alcohol, presenting a comprehensive approach to improving cardiovascular health.

In this episode of the Intelligent Medicine Podcast, Dr. Ronald Hoffman discusses the importance of hydration with Dr. Dana Cohen Integrative Medical Doctor and co-author of “Fuel Up: Harness the Power of Your Blender and ‘Cheat’ Your Way to Good Health.” They explore the often-overlooked role hydration plays in maintaining health and preventing chronic diseases. Dr. Cohen emphasizes practical strategies to improve hydration through diet and lifestyle changes. They highlight the risks of both dehydration and overhydration, discuss the impact of processed foods, and offer realistic solutions to help listeners incorporate better hydration practices into their lives. Too often doctors are dismissive of pop culture exhortations to pay attention to hydration. Except for those with specific medical conditions, the conventional mantra remains “In ordinary healthy individuals, thirst is a good guide to how much fluid you should consume.” In medicine, we routinely query patients about their diets, their exercise, their sleep, their stress levels, drug, alcohol and tobacco use, their social interactions, their spirituality, even their sexuality. But so seldom do we ask “How’s your hydration?” A recent review found that “Hypohydration is known to reduce mental and physical performance, and more recent evidence suggests hypohydration also impairs vascular function and cardiovascular regulation.” But adequate fluid intake is not merely a matter of optimization; a recent medical study sampling 1200 adults aged 51-70  suggests that it may literally be a matter of life and death: “. . . underhydration was significantly associated with increased prevalence of obesity, high waist circumference, insulin resistance, diabetes, low HDL, hypertension, and metabolic syndrome. Over 3–6 years of follow-up, 33 chronic disease deaths occurred in the sample, representing an estimated 1,084,144 deaths in the U.S. Alongside chronic health conditions, underhydration was a risk factor for an estimated 863,305 deaths. Independent of the chronic health conditions evaluated, underhydration was a risk factor for 128,107 deaths.” How prevalent is underhydration in a sample of American adults? According to the study: “Nationally representative data from the National Health and Nutrition Examination Survey (NHANES) indicate that over 65% of adults aged 51–70 years in the U.S. do not meet hydration criteria.” The episode also touches upon broader health issues, contrasting dietary extremes, and the importance of accessible, enjoyable healthy eating habits.

Nutritionist Leyla Muedin discusses the significance of vitamin D, especially during the winter months in northern regions. She explains how the lack of sunlight exposure from October to April can lead to vitamin D deficiency, which is linked to various health issues including autoimmune diseases. Leyla emphasizes the importance of vitamin D for immune function, bone health, and overall well-being. She also offers practical tips on obtaining sufficient vitamin D through supplementation and dietary sources, as well as by safely getting sunlight exposure. The episode highlights recent research on the effects of vitamin D deficiency during childhood development and its potential long-term impacts on health.

Dr. Hoffman continues his conversation with Dr. Michael Karlfeldt, ND, Ph.D., an expert in Integrative Oncology, about the immune-protective effects of ImmPower PLUS AHCC + FWGE-SC. Use coupon code HOFFMAN10 at checkout to get a 10% discount and free shipping.

• Should my stepson take a genetic test to evaluate his risk for pancreatic cancer?
• I had abdominal surgery last month. What can I do or take to minimize scarring?
• I have dry mouth. What treatments can I use to restore saliva?
• Could metoprolol be contributing to my restless legs syndrome?
• I've been diagnosed with a chemical imbalance and prescribed Zyprexa. What are your thoughts? 

“Dead butt syndrome”—you probably already have it; Over half of Americans with uncontrolled hypertension are unaware of their condition; Is a smartwatch app for continuous blood pressure monitoring ready for primetime? What are frequent causes of errors in blood pressure measurement? How long can you continue to take Prolia? What’s the likelihood of a colon adenoma turning cancerous? Metformin scores cognitive and anti-aging benefits in monkeys—human trials underway. 

Dr. Hoffman continues his conversation with Jim LaValle, co-author of "Peptide Handbook: A Professional's Guide to Peptide Therapeutics."

• WHO Study on lifespan vs. healthspan in 183 countries
• Is there a danger in taking a supplement that enhances immunity if you have an autoimmune condition?
• I've had DCIS twice and feel I've received far too many mammograms. Can you discuss overtreatment?

This episode of the Intelligent Medicine Podcast is an enlightening conversation with Dr. Anurag Singh, Chief Medical Officer of <u><a href="https://www.timeline.com/partners/dr-hoffman" target="_blank">Timeline Nutrition</a></u>. They delve into the scientific foundations and benefits of Urolithin A, a unique compound derived from pomegranates and other polyphenol-rich foods, known for its potential to enhance mitochondrial function and promote longevity. Dr. Singh explains the discovery process, the biological mechanisms involved, and the promising results from numerous studies on muscle strength, endurance, immune health, and recovery. They also discuss the compound's applications for those on weight loss drugs, athletes, and individuals suffering from chronic fatigue syndromes. Dr. Hoffman's personal experience with the supplement highlights its significant impact on energy levels and recovery. Lastly, they explore ongoing and future research avenues, emphasizing Urolithin A’s broad-spectrum potential in improving quality of life as we age.

Exploring Vaccine Injuries and Their Implications: Caroline Pover is an award-winning author and public speaker based in the UK. She discusses the highly relevant and timely topic of vaccine injuries, focusing on Caroline's personal experiences and the story of Breanne Dressen, a clinical trial participant who has suffered significant adverse reactions after receiving the AstraZeneca COVID-19 vaccine. Caroline shares insights from her new book, "Worth a Shot?," which chronicles Dressen's journey and the hidden challenges faced by those experiencing vaccine side effects. They delve into the complexities of vaccine injury reporting, the implications of vaccine mandates, and how social media censorship affects the vaccine-injured community. The discussion also touches on potential lifestyle and medical approaches for managing vaccine injuries, emphasizing a compassionate and comprehensive perspective on the issue.

• My husband's doctor is recommending a statin even though his lipid panel is great.  What say you?
• Anti-vaccine doctor wins bid to resume medical practice in Australia.
• Do I need to take vitamin D3 and K2 together? Can I take them at different times of day?
• My liver function tests are normal but my SMA test remains high.  What do I make of this?

Nutritional Insights for a Healthy New Year: Breakfast Ideas and Metabolic Health: Nutritionist Leyla Muedin discusses the importance of a protein and fat-rich breakfast to stabilize blood sugar levels. She emphasizes the metabolic benefits of avoiding carbohydrate-heavy meals in the morning and shares various breakfast ideas that are convenient and nutritious, such as protein shakes, cottage cheese, hard-boiled eggs, and leftovers from previous meals. Leyla also highlights the impact of diet on menstrual health, citing studies showing how ketogenic diets can regulate menstrual cycles and treat conditions like polycystic ovarian syndrome (PCOS). Listeners are encouraged to adopt these dietary habits for better overall health and well-being in the new year.

Jim LaValle, an internationally recognized clinical pharmacist, author, and lecturer, details the emerging field of peptide therapeutics. He discusses the basics of peptides, their roles in various bodily functions, and their therapeutic potentials, including weight loss, immune support, and injury recovery. Jim also shares insights on individualized dosage for GLP-1 drugs, regulatory challenges, the future of peptides in medicine, and exercise tips for seniors. Additionally, Dr. Hoffman explores Jim's role in spearheading the MIORA Longevity Program at Lifetime Gyms, aiming to make gyms not just places for workouts but comprehensive wellness centers focused on longevity and health optimization.

The Importance of Regenerative Agriculture: Nutritionist Leyla Muedin discusses the concept of regenerative agriculture in response to a listener’s question. She explains how regenerative agriculture goes beyond organic practices by enhancing soil quality and promoting a healthier ecosystem. Leyla covers various methods such as composting, crop rotation, and water management, emphasizing the importance of soil health in producing nutrient-dense food and combating global warming. She also highlights the economic advantages of regenerative practices and encourages listeners to support local farmers engaged in sustainable agriculture.

• Study: The impact of exercise on dementia
• Nicotinamide Riboside - does it increase cancer risk and metastasis? 

Is “Morgellon’s Disease” a figment of the imagination? Are reports of frequent liver problems with popular herbs unfairly alarmist? Diagnosing stomach pain; Harmful micro-organisms can travel hundreds of miles high in the atmosphere; Toxic condoms; Sales of herbal supplements soar—we breakdown the most popular; The three tests for cardiovascular risk that you absolutely need. 

“Active holistic therapy” for prostate cancer with diet and fish oil helps defer need for surgery, hormone blockade, radiation; Why 70 is the new 60; Long-term harmful effects of acid-blockers; Do memory supplements pass the blood-brain barrier? Fish oil, krill oil, olive oil for cardiovascular prevention; Paxlovid aggressively promoted but overprescribed for otherwise healthy patients. 

Lex Pelger, a biochemist and educator in cannabinoid science, details unique non-CBD supplements from CV Sciences that have similar beneficial effects on the endocannabinoid system as CBD. The discussion includes the benefits of CBD and cannabinoids, the new +PlusHLTH line (including Peace Gummies, Clarity Gummies, and Reshape Capsules), and their ingredients like berberine, cinnamon, and OEA for metabolic health. They also touch on regulatory challenges and the potential future of cannabis, CBD, and psychedelic research under varying political climates.

• What does standardization in a supplement mean?
• Does the decaffeination process reduce beneficial polyphenols in coffees and teas?
• I've lowered my blood sugar but now my liver function tests are high. What gives?
• Is there a holistic treatment for hyperparathyroidism or is surgery the only option?
• What do you think of Gemtesa for overactive bladder?

How appropriate are cholesterol-lowering guidelines? Are Americans really ready for bans on colorful synthetic food dyes? New powerful drugs promise to slash LDL cholesterol—but are they overused? How to stay fit when arthritis limits exercise; The genetics of acute myeloid leukemia; Cattle feed Bovaer promises to curb methane emissions—but critics claim it’s toxic; Carrageenan may prompt insulin resistance, systemic inflammation; Should you really toss that black plastic spatula?

Announcing the return of Intelligent Medicine to WOR 710 AM in New York City—its original home where the show debuted in 1988! Which is better—being thin or being fit? Why you shouldn’t succumb to pitches for “free” medical devices from Medicare; Does toasting bread make it carcinogenic? Belgium takes lead in protecting the “Anxious Generation” by banning cell phones in schools; The remarkable health benefits of urolithin A (Mitopure®️). 

Dr. Hoffman continues his conversation with Caroline Pover, author of "Worth a Shot?: Secrets of the Clinical Trial Participant Who Inspired a Global Movement―Brianne Dressen's Story."

• I have bronchiectasis. Should I take the pneumonia and RSV vaccinations?
• A friend has hypersomnia and low sodium causing confusion and whole-body tiredness. Your thoughts?
• My husband has been getting a lot of bruising lately since starting Xarelto. Should he reduce his fish oil dose?
• I'm doing everything right and I still can't bring my blood pressure down.  What more can I do at 84?
• What are your thoughts on light therapy patches? Do they work? Are they safe to use?

 

• Highlights from Dr. Hoffman's west coast bike trip
• Study: Light flickering promotes sleep and may protect the brain from dementia
• Could a person be low in omega-6 fats?
• Do you recommend my husband and I get the latest shingles vaccine?

Intermittent fasting with early (9:00-5:00) eating window works best for weight loss, blood sugar control; Beleaguered California Governor Newsom at least gets it right with initiative to curb ultra-processed food, dyes, sugar; Can supplements still be used after their expiration dates? Long-term use of acid-blockers hikes heart risks in women; Quality of patient care threatened by private equity takeovers of hospitals; A tiny camera that you swallow reveals problems lurking deep within the small intestine; High fructose corn syrup fuels tumor growth; RFK Jr. faces congressional grilling next week. 

Dr. Hoffman continues his conversation with Dr. Rob Verkerk, Executive & Scientific Director Alliance for Natural Health International & Alliance for <u><a href="https://drhoffman.com/anh/" target="_blank">Natural Health USA</a></u>.

• How much of the flavanols do I lose by heating cocoa powder?
• My osteoporosis appears to be resolved with bone health nutrients and strontium. Should I continue taking them?
• Is melatonin indicated for osteoporosis? If so, at what dose?
• Is there any way of clearing the spike proteins from one's body after taking the jabs?
• Any recommendations on reducing the residual stiffness of polymyalgia rheumatica? 

• WSJ: Trump nominees 'hawking' supplements?
• Correction on Surgeon General Nominee Dr. Janette Nesheiwat's husband
• I have chronic fatigue. Do you think I would benefit from taking a copper supplement?
• Can I take garlic pills to help my eosinophilic esophagitis?

A healthcare company COO is gunned down—and there could be millions of suspects with a grievance; A simple maneuver can alleviate vertigo; Olive polyphenol found to aid mitochondrial respiration; Gen Z is tiredest generation; Did sickle trait contribute to the death of subway of Jordan Neely? Is screening for sickle trait in athletes a form of discrimination? Daily chores can help women avert cardiovascular events. 

Dr. Hoffman continues his conversation with Carmen Fong, MD, FACS, author of “CONSTIPATION NATION: What to Know When You Can’t Go.”

• Study: Benefits of the combination of cardio and weight training
• What is your opinion on health trackers?
• My heart rate comes down quickly after exercise. Is that good or bad?
• What do you think about infrared mats? I have fibromyalgia and enjoy the heat. 

Doctors fleeing Medicare—leaving patients stranded; CEO murder heightens scrutiny of United Healthcare’s Medicare Advantage coding shenanigans; Can blood pressure spikes cause strokes? Does a calcium score of 20 call for a statin Rx? Treatments for postural orthostatic tachycardia syndrome (POTS); New “improved” tea bags release millions of plastic microparticles; The surprising trigger of a bout of hives. 

Understanding Constipation: Carmen Fong, MD, FACS, author of “CONSTIPATION NATION: What to Know When You Can’t Go,” discusses the pressing issue of constipation. The conversation delves into the definition and causes of constipation, the importance of diet, hydration, and regular bowel habits, and misconceptions around the condition. Dr. Fong shares insights on natural remedies, modern treatments, and factors contributing to early-onset colorectal cancer. The episode also covers hemorrhoid treatments and new medical advances in constipation management.

 

Dr. Hoffman continues his conversation with Dr. Tania Dempsey, an expert in dealing with complex diseases, about Mast Cell Activation Syndrome (MCAS).

Mast Cell Activation Syndrome (MCAS) is a diagnosis that offers a new way of understanding patients with a wide array of elusive symptoms, resistant to conventional therapy. Dr. Tania Dempsey, an expert in dealing with complex diseases, has performed extensive research in collaboration with Dr. Lawrence Afrin, author of "Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity." Dr. Dempsey explains the many manifestations of MCAS, which go beyond mere classical allergies, including headaches, psychiatric symptoms, gastrointestinal problems, and even gynecological and urological complaints. Certain medications can help treat it, along with diet and natural supplements like quercetin, DAO, and luteolin. Triggers may include mold, environmental toxins, stress, and tick-borne infections. There’s even speculation that MCAS may be responsible for some of the symptoms of Long Covid.

Dr. Hoffman continues his conversation with Dr. Barrie Tan, a Ph.D. biochemist who discovered GG, and Dr. David Brady, former director of the Human Nutrition Institute at the University of Bridgeport.

The Annatto plant is valued as a rich source of tocotrienols and a novel, newly-discovered nutraceutical: geranylgeraniol (GG). Dr. Barrie Tan, a Ph.D. biochemist who discovered GG, and Dr. David Brady, former director of the Human Nutrition Institute at the University of Bridgeport and author of numerous books and scientific papers, join us to discuss the roles of tocotrienols and GG in human health. Traditional forms of vitamin E supplements—the tocopherols—are being superseded by tocotrienols as more therapeutic forms of vitamin E. Tocotrienols have shown promise in oncology, for supporting liver health, and for protecting cell membranes as potent fat-soluble antioxidants. GG is ubiquitous as a precursor of diverse compounds including CoQ10, active vitamin K, sex steroids, and proteins. It is useful as a general preventive supplement as well as for specific applications like offsetting CoQ10 depletion in statin users, in metabolic syndrome, and for staving off sarcopenia. Drs. Brady and Tan share their experience in dosing Annatto products, which come in a variety of iterations, alone or teamed with other supplements.

Use of magnesium in Crohn's disease; Study: Association of habitual alcohol intake with risk of cardiovascular disease; If one is taking vitamin C, is a collagen supplement for the skin superfluous?; Is there a good treatment for varicose veins?

Selfies are driving up plastic surgery; Are either glucosamine hydrochloride or potassium sulfate bad for you--especially after long-term use?; What do you think of ZipSlim for weight loss?; Despite being on a strict diet, my cholesterol is 300 and increasing. I would like to avoid statins--what do you recommend?

Is there anything you can suggest to people with MGUS to proactively keep multiple myeloma at bay?; Would you please comment on the recent study that showed no benefits to time-restricted eating?; Our 12-year-old grandson has Sever's disease. Any supplements you would recommend for him?

Study: Glycemic impact the same among grains -- whole and refined; Can you comment on Spermidine as an anti-aging supplement? Does it work the same as NAD?; More comments on Consumer Labs and their critiques.

I'm taking warfarin for atrial fibrillation. Can I take Kyolic aged garlic extract?; Can you discuss the amount of ionizing radiation patients are subject to with calcium scoring tests? Are there alternatives?; I have a Complement C4a test that is very high. What is the significance of this result?; What is the significance of a Melanocyte Stimulating Hormone test in the normal range?

Study: More people are overweight and overtly obese; What impact does olive leaf extract have on bone health? Can long-term use cause antibiotic resistance?; Is organic expeller pressed canola oil bad for me?; My 47-year-old husband has liver spots. Should we be concerned for his liver function?

Dr. Hoffman continues his conversation with Dr. James Min, an expert on cardiovascular imaging and founder and CEO of Cleerly, a company that has developed an improved scan that can differentiate between dangerous unstable plaque, and more benign lesions.

Current ways of visualizing the coronary arteries with calcium scoring are limited: the presence of calcium doesn’t always determine risk; its absence doesn’t fully eliminate the possibility of soft plaque, which is actually more dangerous than stable calcium deposits. Dr. James Min is an expert on cardiovascular imaging and founder and CEO of Cleerly, a company that has developed an improved scan that can differentiate between dangerous unstable plaque, and more benign lesions. The test can be used to establish risk, and then medication and/or lifestyle modification with diet, stress reduction, exercise and supplements can be undertaken. Subsequent tests can yield a report card for how successful the preventive interventions have been. Dr. Min emphasizes that even in settings of high cholesterol the test can show minimal risk, reducing the need for cholesterol medication; conversely, people with low cholesterol may have substantial dangerous plaque. The Cleerly test promises to revolutionize our approach to cardiovascular prevention.

Dr. Hoffman continues his conversation with Ayla Barmmer, a Registered Dietician and functional medicine practitioner, and founder and CEO of FullWell, a fertility wellness and education brand.

Infertility is an increasing problem. Many couples are facing challenges, but few realize that men are an important part of the fertility equation. Sperm quality is recognized to be declining worldwide. Ayla Barmmer, a Registered Dietician and functional medicine practitioner is the founder and CEO of FullWell, a fertility wellness and education brand. She discusses lifestyle factors that affect fertility: exercise, diet, weight optimization, stress, and sleep. Additionally, environmental toxicity can take a toll on sperm and egg viability. A few specific nutrients are essential for fertility optimization, which she enumerates. Not only can barriers to pregnancy be surmounted, but proper pre-conceptual planning can optimize the physical and mental health of offspring—even with lasting trans-generational effects for descendants.

Dr. Hoffman continues his conversation with Ross Arena, Ph.D., professor of physical therapy at the University of Illinois Chicago.

The Covid pandemic should’ve served as a wake-up call, highlighting our vulnerabilities as a nation. Ross Arena, Ph.D., professor of physical therapy at the University of Illinois Chicago, is spearheading a bold initiative called HL-PIVOT to underscore the role that healthy lifestyle plays in enhancing resilience. He is lead author of a new paper that demonstrates the roles that obesity, poor diet, smoking, and inadequate sleep play in setting the stage for poor Covid outcomes. Instead of a pandemic, he argues that we’re experiencing a “syndemic”—a perfect storm of chronic diseases that in themselves exact a terrible toll of chronic illness, but at the same time render Americans more susceptible to Covid. The surprising disparity between US regions with healthier, more active populations versus sedentary precincts within “food deserts” spotlights the important role lifestyle plays as a mediator of Covid severity. Arena argues that this has important social justice implications, with underserved populations experiencing the brunt of the syndemic.

Dr. Hoffman continues his conversation with Dr. John Abramson, author of "Sickening: How Big Pharma Broke American Health Care—And How We Can Repair It."

According to today’s guest, Dr. John Abramson, Americans are getting less bang for their buck when it comes to ever more pricey pharmaceutical drugs. Despite enormous expenditures—17.7% of our GDP—Americans are less healthy and life expectancy lags behind other developed nations. Dr. Abramson, formerly a family practice physician, turned his attention to critiquing the pharmaceutical industry when he realized over-the-top marketing of drugs was at odds with his patients’ interests. He wrote Overdosing America, and became an expert witness in a landmark class action lawsuit over the now-withdrawn drug Bextra. His new book, "Sickening: How Big Pharma Broke American Health Care—And How We Can Repair It," exposes the sleight-of-hand involved in studies that gain approval for new drugs, and how the profit motive distorts optimal drug and device development. Dr. Abramson cites the example of statins as drugs that, while helpful for some, have been vastly overhyped and overprescribed on scant evidence. He takes aim at physician education—both in medical school and post-graduate—as indoctrinating doctors to prescribe drugs with questionable efficacy and undisclosed harms. Dr. Abramson offers an insider’s critique of the medical provisions of the recently passed Inflation Reduction Act—which in fact does little to cap Americans’ skyrocketing outlays for prescription drugs.

Is it possible to be allergic to sugar? I get an extremely sore throat from it.; Can you comment on the pros and cons of pink salt?; I'm in my first trimester of pregnancy. Is there something you can recommend for morning sickness?; My 93-year-old mother has trouble swallowing and needs to take a laxative. Any recommendations?; Why do some organic whole grain cereals contain added sugar?; I believe in taking good care of myself with diet, supplements, and exercise instead of covid jabs. What are your thoughts? I had pre-skin cancer on my forehead and received treatment. Two months later it came back. Was I misdiagnosed?

Save Our Supplements!; Taking statins in the setting of low-carb diets; Are there any downsides to taking L-arginine for erectile dysfunction?; I've developed aphasia and it's progressive. Am I doomed to this neurological deterioration?

Dr. Hoffman continues his conversation with Dr. Alan Gaby, author of the textbook “Nutritional Medicine."

Dr. Alan Gaby comments on bias against nutritional supplements. He recently penned an op-ed entitled “They’re telling us that nutritional supplements are a waste of money”. He is the author of the textbook “Nutritional Medicine” which contains thousands of references to studies substantiating the benefits of supplements. Is there collusion between the pharmaceutical industry, government regulators, politicians, and compliant media to rein in the supplement industry? Why has the press uncritically focussed on the alleged harms of supplements? What’s wrong with studies claiming lack of efficacy of multivitamins, fish oil, and vitamin D? Dr. Gaby takes an even-handed approach, citing instances of over-arching claims about nutrients; he urges “humility” and scientific rigor in nutrition science, and decries the missed opportunity for study of the promising roles of diet, lifestyle, and nutraceuticals afforded by our quest for measures to control the pandemic.

Dr. Hoffman continues his conversation with Dr. William Grant, one of the world’s foremost vitamin D researchers.

Recently, headlines have proclaimed that vitamin D is ineffective, that we shouldn’t bother testing for it, and that most people shouldn’t bother taking it. Pushing back on those assertions is Dr. William Grant, one of the world’s foremost vitamin D researchers with over 60 published studies. His latest paper explains why research on vitamin D is plagued by methodological errors and colored by bias against nutritional supplements that might supplant pharmaceutical drugs. Dr. Grant explains how vitamin D, far from being just a “bone vitamin”, can impact a wide range of conditions ranging from dementia and Alzheimer’s, cardiovascular disease, diabetes, mood disorders, and cancer; studies have shown it improves pregnancy outcomes and extends life; the latest research suggests a benefit for respiratory infections and Covid. We also discuss the important role sunlight exposure plays in vitamin D synthesis, and how wrong-headed health authorities have stigmatized sun exposure to great detriment. What levels are best? How much to take? Is there an upper limit? Dr. Grant is currently the director of the Sunlight, Nutrition, and Health Resource Center.

Dr. Hoffman continues his conversation with Dr. Bill Rawls, author of "The Cellular Wellness Solution."

Dr. Bill Rawls, author of "The Cellular Wellness Solution," joins us to discuss the role of herbal supplements in natural medicine. He prefers to use herbs, not merely as individual panaceas, like the way we deploy drugs to alleviate symptoms, but rather as part of a comprehensive strategy comprising lifestyle to optimize cellular wellness. Dr. Rawls relates how a personal health crisis impelled him to seek natural solutions. He dishes on supplement quality and how consumers can safely access the benefits of quality nutraceuticals. We focus on herbal supplements for immunity, PMS and menopause, inflammation, GI conditions, and cognitive health. Dr. Rawls explains the key role adaptogens play. He reassures us that, with proper knowledge, harmful herb-drug interactions can be avoided.

Save our Supplements!; What is the lowdown on iodized salt? Do we really need it?; Is salt making me fat?; A recent chest CT scan shows that my thyroid gland is atrophic. What does this mean?; What are your thoughts on stem cell therapy?

Food company executive commits cannibalism; New face mask can diagnose respiratory viruses; Study identifies gut bacteria that regulate cholesterol; Does functional medicine offer any appreciable help in patients with eosinophilic esophagitis?; What do you think of magnesium spray versus taking an oral magnesium supplement?