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ID:IOTS - Infectious Disease Insight Of Two Specialists ( Infectious Disease: Insights of Two Specialists)

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DateTitreDurée
07 Feb 202215. Corynebacterium: Dip into Diphtheria00:22:13

In this episode we continue exploring the realm of Gram positive bacilli. Jame and Callum discuss Corynebacterium looking at Diptheroids and Diptheria and explaining the difference.

We're going to spend the next few episodes talking about Gram positive Bacilli and the infections they cause.

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21 Feb 202216. Laying into Listeria, Lactobacillus and 'lothrix00:16:31

In this episode we continue exploring the realm of Gram positive bacilli. Jame and Callum discuss Listeria, Lactobacillus and Erysipelothrix. These complete the "non-branching GPBs" we are discussing, along with Bacillus and Corynebacterium.

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07 Mar 202217. Branching into the Branching (aerobic) GPBs00:29:12

In this episode Jame and Callum discuss Nocardia and Actinomyces, continuing the journey through Gram positive bacilli.

We'll move away from GPBs in the next few episodes before returning to discuss anaerobic GPBs.

Send any suggestions to idiotspodcasting@gmail.com, thanks to all those who have submitted feedback and suggestions already!

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Feel like giving back? Donations of caffeine gratefully received!
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21 Mar 202218. The ID:IOTS Guide to Cephalosporins00:36:08

Callum and Jame provide an overview of the Cephalosporin class of antibiotics, discussing mechanism of action, spectrum, classification, PK/PD, side effects and some clinical uses.

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04 Apr 202219. Neiserria knowledge00:48:51

In this episode Jame and Callum talk through the two most medically important Gram negative cocci: Neisseria meningitidis and Neisseria gonorrhoeae.

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18 Apr 202220. Weird lactams00:32:03

In this episode Jame and Callum discuss other Beta-lactam antibiotics: aztreonam, temocillin and pivmecillinam... with some substantial tangents into C. difficle and carbapenems. 

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09 May 202221. Exploring E. coli and the order of Enterobacterales00:35:26

Jame and Callum have put this off for far too long... we start exploring the Gram negative bacilli by considering Enterobacterales in general and then discussing E. coli. We focus particularly on the gastrointestinal syndromes causes by different pathogenic strains of E. coli. Did you ever wonder what "coliforms" on a culture result meant - hopefully now you will find out!

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16 May 202222. Konquering Klebsiella00:20:23

Jame and Callum continue their discuss of the Enterobacterales, looking at Klebsiella spp. with focused discussion on some microbiological history, K1 syndrome, and the pharmacokinetics of antimicrobials for endophthalmitis.

For the graphic Jame suggested look at Figure 4 in this paper:  https://academic.oup.com/femsre/article/41/3/252/3830265

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Feel like giving back? Donations of caffeine gratefully received!
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01 Jun 202223. The ID:IOTS guide to Carbapenems00:32:18

Callum and Jame provide an overview of the Carbapenem class of antibiotics discussing: what they are; their spectrum of action (looking in particular at what they don't cover); resistance; how to use them; and side effects.

This site has a useful summary of the new formulation of carbapenems and their spectra:
http://www.microbiologynutsandbolts.co.uk/the-bug-blog/new-sweets-on-the-market-but-will-these-new-flavours-live-up-to-their-vibrant-colours

Here is the NEJM paper on Tebipenem Jame mentions:
https://www.nejm.org/doi/full/10.1056/NEJMoa2105462

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Feel like giving back? Donations of caffeine gratefully received!
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24 Jun 202224. Ambl(er)ing through beta lactamases01:03:55

Join Jame and Callum as they discussion all things beta lactamase including ESBL, AmpC and Carbapenemases.  We talk through classification systems, patterns of resistance and some methods of detection. 

Some resources we found helpful:

Summary of beta lactamase classification:
https://microbeonline.com/betalactamase-classification/

Summary of AmpC:
https://www.idstewardship.com/heck-yes-get-amped-updates-ampc-harboring-bacteria/

EUCAST detection of resistance:
https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Resistance_mechanisms/EUCAST_detection_of_resistance_mechanisms_170711.pdf

UK SMI on Carbapenemases:
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1080594/B_60i3.1.pdf

More in depth AmpC:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763639/

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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25 Jul 202225. MALDI-TOF talk00:24:57

Back after a summer break, Jame and Callum discuss the fascinating machine that is the MALDI-TOF. Matrix Assisted Laser Desorption Ionisation Time Of Flight mass spectrometry. We discuss the basics of how it functions, its application in the lab and some pros and cons of its use along with what the future may hold. Here are some relevant videos and papers:

- Exciting video of MALDI-TOF
https://www.youtube.com/watch?v=0jeFpXHZ8W0&ab_channel=BrukerDaltonics
- MALDI-TOF to detect MRSA https://www.frontiersin.org/articles/10.3389/fmicb.2020.00232/full
- Direct MALDI-TOF on blood cultures 
https://www.spandidos-publications.com/10.3892/etm.2020.9365
- MALDI-TOF to detect CPE
https://www.frontiersin.org/articles/10.3389/fmicb.2021.789731/full 

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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28 Jul 202226. Happy birthday ID:IOTS00:09:35

ID:IOTS is 1 year old today! Jame and Callum have a short chat about the the podcast, why we started and where we’re going. Of course, the real ID:IOTS are the friends we made along the way…

If you want to send us cake email idiotspodcasting@gmail.com

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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08 Aug 202227. MurDeRing MDR Gram negs. Part 1: AmpC&ESBL00:42:58

Join Jame as he talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts.

ECDC guidelines

·          https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x

·          https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0

 Canadian guidelines

·          https://www.canada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2018-44/ccdr-volume-44-1-january-4-2018/ccdr-rmtc-44-1-ar07-eng.pdf

 IDSA

-       https://www.idsociety.org/practice-guideline/amr-guidance-2.0/# 

 Comparison of IDSA and ESCMID

-       https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00054-4/fulltext 

-       https://amr.solutions/2019/01/13/categories-of-resistance-mdr-xdr-pdr-udr-and-new-dtr/


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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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15 Aug 202228. MurDeRing MDR Gram negs. Part 2: CREs00:19:04

Join Jame as he continues to talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts.

ECDC guidelines

·          https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x

·          https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0

 Canadian guidelines

·          https://www.canada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2018-44/ccdr-volume-44-1-january-4-2018/ccdr-rmtc-44-1-ar07-eng.pdf

 IDSA

-       https://www.idsociety.org/practice-guideline/amr-guidance-2.0/# 

 Comparison of IDSA and ESCMID

-       https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00054-4/fulltext 

-       https://amr.solutions/2019/01/13/categories-of-resistance-mdr-xdr-pdr-udr-and-new-dtr/

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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29 Aug 202229. Expanding on the Enterobacterales00:34:27

Join Jame and Callum and they discuss some of the other Enterobacterales Gram negatives. Particularly breaking down them into their families and into Lactose fermenters and non-fermenters. Jame has a small breakdown around our Twitter handle near the end.

Comments suggestions and criticisms to idiotspodcasting@gmail.com or @IDiots_pod

Some lists:
Chromosomal AmpC Carriers (high-risk): HECK YES

·         Hafnia alvei, Enterobacter cloacae, Citrobacter freundii, Klebsiella aerogenes, Yersinia enterocolitica

Lower Risk Chromosomal AMPC: Vulgar Providencia Store AMPC

·         Proteus Vulgaris, Providencia, Serratia, Acinetobacter, Morganella, Providencia

 Intrinsic Colistin Resistance: 

·         Burkholderia cepacia (Nonfermenter), Proteus, Providencia, Serratia

 Biochemical mimics of Salmonella (also can group)

·         Hafnia, Morganella,Proteus

 Cat 3 organisms: 

·         Salmonella typhi/paratyphi, Shigella dysenteriae type 1, E.coli O157, Yersinia Pestis



Some useful resources:

SMI ID 16: identification of Enterobacteriaceae

https://www.gov.uk/government/publications/smi-id-16-identification-of-enterobacteriaceae

 Janda JM, Abbott SL. 2021. The changing face of the family Enterobacteriaceae (order: “Enterobacterales”): new members, taxonomic issues, geographic expansion, and new diseases and disease syndromes. Clin Microbiol Rev 34:e00174-20. 

https://doi.org/10.1128/CMR.00174-20 

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12 Sep 202230. Say Yes to the Yersinia00:35:02

Yersinia. Not very important today, very very important in the past! Callum and Jame talk through the medically important Yersinia species, and how to treat them. 

Links: 

CDC page for treatment of plague: 
https://www.cdc.gov/plague/healthcare/clinicians.html

UK HSA SMI 21: ID of Yersinia Species
https://www.gov.uk/government/publications/smi-id-21-identification-of-yersinia-species-from-faeces

The 'Jump' test for mesenteric adenitis Jame mentioned has a name (the J-up test), and it works! Sensitivity 87%, Specificity 70%.
DOI: 10.1177/2333794X19884824

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26 Sep 202231. Salmonella and Shigella00:49:18

Join Jame and Callum as they discuss the two titans of diarrhoea, Salmonella and Shigella. Who knew Salmonella species were so complex? Jame explains something that will SHOCK you about Shigella (maybe).

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Useful resources:
Review of Salmonella: Shu-Kee Eng, Priyia Pusparajah, Nurul-Syakima Ab Mutalib, Hooi-Leng Ser, Kok-Gan Chan & Learn-Han Lee (2015) Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance, Frontiers in Life Science, 8:3, 284-293, DOI: 10.1080/21553769.2015.1051243

Original article on Edinburgh S. Typhi outbreak investigation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130034/pdf/jhyg00084-0045.pdf

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10 Oct 202232. Hurrying through Haemophilus00:40:11

Join Jame and Callum as they talk you through Haemophilus spp. Turns out that Haemophilus influenzae isn't the cause of Influenza. We answer some questions such as: What are X and V?

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Useful resources:
-SMI on HACEK organisms https://www.gov.uk/government/publications/smi-id-12-identification-of-haemophilus-species-and-the-hacek-group-of-organisms 
-Dermnet page on Chancroid https://dermnetnz.org/topics/chancroid
- EUCAST breakpoints page https://www.eucast.org/clinical_breakpoints 


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25 Oct 202233. The ID:IOTs Guide to Aminoglycosides00:55:23

Callum and Jame talk about everyone's favourite antibiotic class that covers Staph, Pseudomonas and Gram negatives, is predominantly renally excreted and isn't a quinolone, the aminoglycosides. We go over classification, mechanism of action, spectrum, resistance mechanisms, PK/PD, penetrance to various tissues, toxicity, and dosing. 

This is a companion piece to our star appearance on Febrile in August: https://player.captivate.fm/episode/0777091c-0991-42d4-89a9-4032d77b4fa5


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14 Nov 202234. Arguing about atypicals00:16:54

An atypical episode about pneumonia. Callum and Jame discuss their pet peeves. 

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28 Nov 202235. ...arriving at ACEK00:33:51

Callum and Jame discuss the HACEK organisms (apart from Haemophilus which we discussed in episode 32). 

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12 Dec 202236. Urinalysis paralysis00:40:49

Join Jame and Callum as they take a deep dive into urinalysis, a commonly (mis)used test for UTI (and other conditions). This test put you into murky waters when used clinically and we hope to give some information to avoid being a pisse prophet.

Some sources referred to in this episode:
NICE Clinical knowledge summary
SMI 41: Investigation of urine

Summary article of PPV and NPV for urinalysis:
- Diagnosis and treatment of urinary tract infections across age groups, AJOG, 2018

Performance of LE and Nitrite at differing levels of bacteruria:
Evaluation of Leukocyte Esterase and Nitrite urine dipstick, J Clin microbiol, 1999

Review of urinalysis diagnostic utility by presenting symptoms:
Does this woman have an acute uncomplicated urinary tract infection? JAMA 2002




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25 Dec 202237. The Tragedy of Plazomicin00:22:43

This Christmas, Jame shares a tale of woe: the rise and fall of Plazomicin, a hapless victim of antibiotic market forces. The conversation then proceeds/degenerates into a discussion of the economics of Antimicrobials in general, with a focus on the ‘Netflix’ model being piloted in the UK.  

WE’LL BE BACK NEXT YEAR SEE YOU THEN

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09 Jan 202338. Gram positive vs negative bacteraemia - SHOWDOWN!00:30:28

In this episode as requested on twitter (sort of),  Callum & Jame compare and contrast Gram positive & negative bacteraemia. Happy new year!

Please also see our older episode on bloodstream infection: www.buzzsprout.com/1782416/9162105-5-back-to-bacteraemia

SABATO trial details here: https://twitter.com/sebpoule/status/1518496524552056833?s=46&t=Dre0YLRm_gwnKQ8OakDarw

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23 Jan 202339. ID:IOTS Journal Club: 3 days treatment for CAP00:41:49

It's time for journal club! Jame and Callum discuss community acquired pneumonia treatment and a paper from 2021 which examines shorter duration therapy for patients responding to therapy.

Paper discussed:
Dinh, Aurélien et al. “Discontinuing β-lactam treatment after 3 days for patients with community-acquired pneumonia in non-critical care wards (PTC): a double-blind, randomised, placebo-controlled, non-inferiority trial.”
Lancet 2021;397: 1195-1203.
doi:10.1016/S0140-6736(21)00313-5

Shorter is Better site:
https://www.bradspellberg.com/shorter-is-better

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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06 Feb 202340. FRCPath part 2 Microbiology exam - Prepping to Pass01:03:08

Jame and Callum are joined by recent FRCPath Microbiology part 2 exam passers Olly and Rob to discuss how best to prepare for the exam. This is the final exam required to qualify as a medical/clinical microbiologist in the UK. 

Full revision resources notes available in the linked OneDrive folder below (if you can't access it let us know!). Let us know once you pass!


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20 Feb 202341. Bugs Without Borders: a conversation with Microbe Mail!00:53:05

Jame and Callum are joined by Vin from Microbe Mail to discuss the management of Difficult to Treat Resistance (DTR) Gram negative infections in South Africa.

If you haven't already check out Microbe mail for a high quality infection podcast linking the lab and clinical management.... wait that sounds familiar!

Vin is a associate Professor in Clinical Microbiology at the University of the Witwatersrand, Johannesburg, South Africa and a practising clinical microbiologist with the National Health Laboratory Service. She is passionate about microbes (of course), antimicrobial resistance, antimicrobial stewardship, diagnostics, healthcare associated infections, fungal infections, One Health...let's just say it's a very long list!

References:


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06 Mar 202342. FRCPath part 1/CICE - Prepping to Pass00:43:07

Jame and Callum are joined by semi-recent FRCPath Microbiology part 1 exam passers Callum and Jame to discuss how best to prepare for this exam. This exam is sat by all infection trainees in the UK, as well as other health care professionals working in infection such as clinical scientists. 

Full revision resources notes available in the linked OneDrive folder below (if you can't access it let us know). 

Let us know once you pass! (Disclaimer: previous sentence for engagement purposes only, please do not let us know once you pass). 

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20 Mar 202343. ABIM ID board exams - Prepping to Pass00:47:42

Jame and Callum are joined by the one and only Sara Dong of Febrile fame to look at the American Board of Internal Medicine's Infectious Disease Certification Exam. 


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03 Apr 202344. The Basics of Beta Lactamase Inhibitors00:29:44

Jame rides solo today, going over the beta-lactamase inhibitors, old and new, how to think about them and when to use them in anger. 

New Show notes format! Available at https://idiots.notion.site/Beta-Lactamase-Inhibitors-f9999b6a4867470996a31c53e661b5ac

NB: For now all old show notes are available in the usual Onedrive folder. 

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24 Apr 202345. ECCMID highlights part 1: Archaea, Digitalisation and the IDSA00:32:12

Callum is reunited with Jame following their separation at ECCMID 2023. Callum shares some highlights including Archaea and their role in human health, Digitalisation within the microbiology lab and the ESCMID/IDSA interview

Links to publications on Archaea:
https://www.moissleichingerlab.com/projects/
https://twitter.com/chmoei?lang=en

Digitalisation and machine learning in microbiology presentation link: https://appliedmicrobiologyresearch.net/en/blog/keynote-by
https://twitter.com/AppliedMicrobi2?s=20

Carlos del Rio, president of the IDSA
https://twitter.com/CarlosdelRio7?s=20

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26 Apr 202346. ECCMID highlights part 2: UTI antibiotic stewardship, CMV & BK, Responsible Publishing, HLH00:24:58

Join Callum with Guests Robert Ball, Kelly Bicknell & Rob Read live from ECCMID 2023. 

ECCMID sessions discussed:

  • Antibiotic stewardship for urinary tract infections: challenges and opportunities
  • Viral Infection in immunosuppressed patients: what is new?
  • Responsible publishing in CM/ID
  • Secondary haemophagocytic lymphohistiocytosis and infectious diseases


Review article on HLH:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094004/

Music:
https://pixabay.com/music/acoustic-group-outrigger-144123/

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28 Apr 202347. ECCMID highlights part 3: Mythbusting, Sporotrichosis, phages, AMR, Paeds, Grand Round00:33:00

Join Callum with guests Andrew Seaton, Marianna Avellar, Hannah Pymont, Eva Garmendia, Sanjay Patel and Dave Hettle live from ECCMID 2023.

ECCMID sessions discussed:
- Fairytales or reality, checking some eminence paradigms for treatment of severe infections
- Neglected tropical skin diseases
- Non-canonical approaches to treatment of infections
- Paediatric interactive cases: dilemmas for the microbiologist and infection specialist
- Clinical grand round

For the AMR studio podcast: https://www.uac.uu.se/the-amr-studio/ 

BSAC paediatric pathways: https://bsac.org.uk/paediatricpathways/

Music: https://pixabay.com/music/acoustic-group-outrigger-144123/

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01 May 202348. ECCMID highlights part 4: Antimicrobial stewardship, Antibiotics at end of life, Behaviour science and tick borne infections00:32:21

Join Callum with guests Morgan Evans, Olivia Hawkes and Katy Hill for the final(?) part of the ECCMID 2023 highlights

ECCMID sessions discussed:
- Antimicrobial stewardship poster session
- Ethical dilemmas with antimicrobial therapy
- The value of diagnostic information for antimicrobial stewardship
- Tick borne diseases and prevention


Music: https://pixabay.com/music/acoustic-group-outrigger-144123/ 

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06 May 202349. Penicillin Allergy 2: Delabel Harder00:30:37

Welcome to the party pal! The penicillin allergy assessment and delabelling party, that is. Callum takes Jame through the latest evidence base in antibiotic allergy in general, and beta lactam allergy assessment and management in particular. 

Links: 
PENFAST Score paper: 
Trubiano JA et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. doi: 10.1001/jamainternmed.2020.0403.

Sulfonamide allergy paper here (couldn't find anything published more recently): 
Urbancic KF et al. Taking the challenge: A protocolized approach to optimize Pneumocystis pneumonia prophylaxis in renal transplant recipients. doi:10.1111/ajt.14498

Dutch beta lactam allergy guidelines: 
https://swab.nl/en/exec/file/download/192

And finally...
Norvell MR et al. Cefazolin vs. second-line antibiotics for surgical site infection prevention after total joint arthroplasty among patients with a beta-lactam allergy. https://doi.org/10.1093/ofid/ofad224

Yippee Ki-Yay, my delabellers, we'll see you in a fortnight. 

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30 May 202350. FRCPath exams for clinical scientists - prepping to pass00:39:38

Ever wondered what a clinical scientist is or how to become one? Are you a clinical scientist and looking to sit the FRCPath exams? Join Jame and Callum as they talk to Phillipa Burns and Vicki Fleming about their experiences in preparing for their FRCPath exams in microbiology.

Here are some of the resources mentioned during this episode:
Colour atlas of bacteriology
UK Reference laboratory manuals
Tropical Medicine Notebook
Bailey & Scott's Diagnostic Microbiology, 15th Edition

 Review agars from the manufacturer:
EO labs
Oxoid

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13 Jun 202351. Taking the Piss: Urine Culture, Unravelled00:54:13

The title says it all. We're going back to the lab for this discussion. Join Jame and Callum as they have an in depth discussion about the nature of urine culture.

Prep notes for this episode available here

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26 Jun 202352. Escalation Emancipation00:35:23

Loyal Listeners! Free yourselves from this outdated language! Emancipate your hospitals from 'Escalation antibiotics'!

In today's episode, Callum and Jame rant for 35 minutes about how we talk about changing therapy, and how talk of escalating antibiotics leads to desire for 'big gun' antibiotics.

Apologies for Callum's audio quality on this episode. We'd apologise for Callum in general, but you chose to listen, really you've only yourself to blame.

Links:
Tunnocks Tea Cakes
Ledaig whisky
ID:IOTS guide to Aminoglycosides

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10 Jul 202353. Clobbering CAUTI01:14:29

Catheter-associated UTI: Callum’s nemesis. His white whale. His Sauron. His favourite rant. 

Want to know how favourite? Listen on!

Show notes for this episode here


Useful links (see show notes for more)
RICAT study
Chlorhexidine meatal cleaning

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24 Jul 202354. Antibiotics for UTIs00:58:21

This is the urine antibiotic drug penetrance you never knew you wanted. Jame might be prouder of this than his own children. Callum, as you will be able to tell, remains indifferent*.

Figure out which antibiotics you can trust, and which you can't. Use the table in the prep notes and links to win arguments, justify treating 'resistant' organisms in the urine, BREAK HEARTS - you name it!

Enjoy! 

Prep notes for this episode: https://idiots.notion.site/UTI-Drug-Choice-5deb611895254444a040bf78d2003cdb

*To the episode, he thinks Jame's children are delightful. 

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07 Aug 202356. Antibiotics, Breastfeeding and Infant Health01:08:34

We were delighted to be joined by Dr Anastasia "Tash" Theodosiou to talk about breastfeeding, antibiotics and the risks of antibiotic harm to mum and baby. Tash is an infectious diseases/medical microbiology trainee, host of the HelloMicro blog and has volunteered as a Breastfeeding Peer Supporter.

*Note the NICE guidelines have been updated and do not recommend trimethoprim in any stage of pregnancy

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28 Jul 202355. The ID:IOTS annual report 202300:21:34

2 years. It’s been a hell of a ride. Here’s to 2 more. 

Links from this episode: 

KASIC 1-page evidence-summary on aminopenicillins for resistant enterococcal UTIs:  https://bit.ly/44CtNnq


AUDIENCE SURVEY!!! 

Please do fill this out, it would mean a lot to us: https://forms.gle/aCq2djmfKPjA6tkMA

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04 Sep 202359. Nobbling the Nonfermentors: Pseudomonas Part 100:32:19

It was a long time coming, but it’s here. Jame and Callum set off on our mini-series, Nobbling the Nonfermentors, starting with an introduction to glucose-nonfermenting organisms before moving on to the biggie: Pseudomonas aeruginosa! 

Part 2 next week covers treatment of Pseudomonas, including a deep dive into Pseudomonas resistance mechanisms. Stay tuned!

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11 Sep 202360. Nobbling the Nonfermentors: Pseudomonas Part 2 - Treatment & Resistance00:44:54

In part 2, we discuss the limited treatment options for pseudomonas infection, some wildcard options and the resistance mechanisms that make Pseudomonas such a tricky bugger to treat! 

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22 Aug 202357. Antimicrobial stewardship begins at home00:23:03

Jame and Callum are together in person to talk about the importance of keeping your house in order. Being an infection specialist does not automatically make you an antimicrobial steward. We reflect on some challenges to being an antimicrobial steward  when practising infection medicine

The choosing wisely campaign mentioned by Jame:
https://www.choosingwisely.org/

A course on Antimicrobial Stewardship which is a good starting point:
https://www.futurelearn.com/courses/antimicrobial-stewardship

The IDSA guidance on AmpC production risk organisms mentioned by Jame:
https://www.idsociety.org/practice-guideline/amr-guidance/#AmpC%CE%B2-Lactamase-ProducingEnterobacterales

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29 Aug 202358. Mythbusting Cidal vs Static with Microbe Mail00:41:36

Jame and Callum were delighted to be invited as guests to the podcast Microbe Mail by host Vindana (Vin) Chibabhai. Check out the Microbe Mail podcast:
https://microbemail.captivate.fm/  @microbemail

We discuss how bactericidal and bacteriostatic are defined, what the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) are and why this isn't as simple as it first seems. We then discuss specific clinical situations and where bactercidal vs static have been compared.

Links/papers mentioned in this episode:

The basics of beta lactamases

Wald-Dickler N, Holtom P, Spellberg B. Busting the Myth of ‘Static vs Cidal’: A Systemic Literature Review. Clin Infect Dis. 2018 17;66(9):1470–4.

Use of bacteriostatic agents in Neutropenic fever:

The RCT referred to in the abstract is here:
Jaksic B, Martinelli G, Oteyza JP, Hartman CS, Leonard LB, Tack KJ. Efficacy and Safety of Linezolid Compared with Vancomycin in a Randomized, Double-Blind Study of Febrile Neutropenic Patients with Cancer. Clinical Infectious Diseases. 2006 Mar 1;42(5):597–607

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02 Oct 202361. Nobbling the Nonfermentors: Acinetobacter Part 100:26:56

In this episode, Callum and Jame go over the second big family of nonfermentors, Acinetobacter. In part 1 we talk about the organisms themselves, risk factors, clinical syndromes and diagnostics before talking a little about treatment. 

In Part 2 (released next week) we’ll talk about Carbapenem-Resistant Acinetobacter Baumanii-calcoaceticus (CRAB), and resistance mechanisms in general. 

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09 Oct 202362. Nobbling the Nonfermentors: Acinetobacter Part 2: Resistance & CRAB00:43:05

In Part 2 of our episodes on Acinetobacter we talk abouit resistance, and then do a deep dive into the evidence base for the management of CRAB: Carbapenem-Resistant Acinetobacter Baumanii-calcoaceticus complex.

Do have a look at the prep notes for this episode if you want more information on Acinetobacter.

Links to podcasts mentioned in this episode

ID:IOTS Episode 41: Bugs Without Borders

Febrile episodes 76 & 77: Piece de (Gram-negative) Resistance
Episode 76
Episode 77

For links to the papers we used, see the prep notes

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06 Nov 202364. Let’s talk tests with Let’s Talk Micro00:42:19

In this episode Jame and Callum are joined by Louis, host of the let's talk micro podcast.

Listen in for a discussion on what a Biomedical Scientist is and how to become one. We explore the key details that clinicians need to add to their specimen request details; and ponder how laboratory managers can make this easier for clinicians.


How to request a test:
https://global.oup.com/academic/product/how-to-request-a-test-a-clinicians-guide-to-the-interpretation-and-evaluation-of-medical-tests-9780192866615?cc=gb&lang=en&

Let's talk micro podcast:
https://rss.com/podcasts/letstalkmicro/ 

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23 Oct 202363. Nobbling the Nonfermentors: Stenotrophomonas maltophilia00:52:44

Ready for some startling Steno statistics? In this big 1-parter, Callum & Jame go through Stenotrophomonas maltophilia, from start to finish. 

Unlike Pseudomonas & Acinetobacter, Steno is much less commonly seen outside of ITU & the immunocompromised; but when it shows up you have to know what you’re doing. Luckily for you, there’s basically only 2 treatments! (In Europe: you’ll see what I mean).

2 crap puns in this one, so… get ready for that. 

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27 Nov 202366. FIS highlights 2 - Neurosurgical infections, parasitology reg, anti-fungals, NITCAR00:34:48

Join Jame, Callum and Pals for a discussion on some highlights from FIS 2023: https://microbiologysociety.org/event/full-events-listing/federation-of-infection-societies-fis-conference.html

Mentioned in episode:
ESCMID brain abscess guidelines: https://www.sciencedirect.com/science/article/pii/S1198743X23003993#
ORAL study protocol: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05783-8

ACBLM/ALM: https://www.acb.org.uk/

Pathology networks: https://www.england.nhs.uk/pathology-networks/

UCLH/HTD: https://www.uclh.nhs.uk/our-services/find-service/tropical-and-infectious-diseases
uclh.parasitologyspr@nhs.net

Review article on anti-fungal resistance and global health: https://www.nature.com/articles/s41579-022-00720-1

NITCAR website: https://nitcollaborative.org.uk/wp/

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20 Nov 202365. FIS highlights 1 - SNAP trial, AMR musical, S. aureus update, IPC in LMIC00:27:34

Join Jame, Callum and Pals for a discussion on some highlights from FIS 2023: https://microbiologysociety.org/event/full-events-listing/federation-of-infection-societies-fis-conference.html

Mentioned in episode:

UCHL HLH protocol and referral details: https://www.uclh.nhs.uk/our-services/find-service/medical-specialties-1/hlh-service
SNAP trial: https://www.snaptrial.com.au/
SNAP trial email: snap-trial@unimelb.edu.au
SABATO (pre-print) https://www.medrxiv.org/content/10.1101/2023.07.03.23291932v1

RESISTANCE/The Mould that Changed the World: https://www.mouldthatchangedtheworld.com/

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04 Dec 202367. FIS highlights 3 - Fungal Diagnostics, Linezolid & Serotonin Syndrome, SABATO Trial, Rabies, PK/PD Dosing of Antibiotics00:31:33

Callum and Jame wrap up their thoughts on the recent FIS conference. 

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18 Dec 202368. Nobbling the Nonfermentors: Burkholderia cepacia Complex00:52:17

Did you think the  evidence base for Stenotrophomonas was bad? Well allow  us to introduce you to Burkholderia cepacia complex!

BCC is pretty niche but a key pathogen in people living with cystic fibrosis. We talk through the (very) limited treatment options and evidence base for this difficult bug.

Prep notes for this episode here: https://idiots.notion.site/68-Burkholderia-cepacia-complex-7bba8a7c74df490cb2e91d087a3cdb2a

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25 Dec 202369. Choosing an antimicrobial00:22:24

How do you think about antibiotics?

This Christmas we give the best gift of all: no puns in an episode.
Join Jame and Callum as they talk about a method for thinking about and explaining antibiotics.

Here are the show notes for this episode: https://idiots.notion.site/69-Choosing-an-antimicrobial-4e7446a91ff6413aa14924a2ba905ffa 

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08 Jan 202470. Part 2 FRCPath reflections and Desert Island Antibiotics00:53:11

In this Episode, Callum reflect on his recent runaway success passing the FRCPath Part 2, passes on some tips and tricks for the exam, and then we talk about what 3 antibiotics we would take with us to a Desert Island (that has all pathogens and environments where you would find said pathogens, so not just a desert apparently).

'Prepping to Pass' episodes mentioned: 40, 42, 43 & 50.

The Table and Links mentioned in this episode can be found here: https://idiots.notion.site/70-Reflections-on-Part-2-2023-a193fd830c9b4d6c9381107471fcdbca

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12 Feb 202472. IDIOTS journal club: the SABATO trial00:39:31

JOURNAL CLUB, YO, IT’S A SABATO!!!

Join Jame and Callum as we travel back in time to when we recorded this deep dive into the SABATO trial pre-print, now peer-reviewed and published in the Lancet ID!

In the next episode we'll give a little update as to how the final article differs from the preprint (not much).

We also talked about in our FIS Highlights Episode 3.

We loved this trial and we hope you’ll all give it a read, it’s well worth it!

Article here:
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.
PMID: 38244557.
https://doi.org/10.1016/S1473-3099(23)00756-9

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29 Jan 202471.Nobbling the Nonfermentors: Burkholderia pseudomallei - Melioidosis00:39:43

In this penultimate episode in the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the regionally important neglected tropical disease Melioidosis, caused by Burkholderia pseudomallei.

This episode was based disproportionately on the following article, and we extend our thanks to the authors for thoughfully publishing it so close to us wanting to do a podcast episode on Melioid!

Meumann, E.M., Limmathurotsakul, D., Dunachie, S.J. et al. Burkholderia pseudomallei and melioidosis. Nat Rev Microbiol (2023).

https://www.melioidosis.info/

Link to prep notes here.

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13 Feb 202473. SABATaddendum00:05:56

Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state.

Final article here:
Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial, Kaasch, Achim J Valiente, Adoración et al. Lancet Infect Dis. 2024 Jan 17:S1473-3099(23)00756-9.
PMID: 38244557.
https://doi.org/10.1016/S1473-3099(23)00756-9

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25 Feb 202474. Nobbling the Nonfermentors: Burkholderia mallei - Glanders00:24:57

In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders. 

We did it. We got to the end. 

Nonfermentors... Nobbled. 

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11 Mar 202475. PK: Blethering about Bioavailability00:41:16

It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice.

Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our prep notes (including for this episode) here

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24 Mar 202476. PK: Dithering on distribution00:41:21

It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification).

What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode for you! Check out our prep notes (including for this episode) here

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08 Apr 202477. PK: Illuminating Elimination00:43:29

The last Pharmacokinetics episode had finally been …Excreted!
 
 This episode  covers the ‘drug out’ bit of pharmacokinetics, including things such as:
 
 -What is clearance?
 -how to calculate half life
 and
 -doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up).
 
 Check out our prep notes (including for this episode) here

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21 Apr 202478. PK: Pharmacokinetics summary00:26:29

One PK table to rule them all
One table to find them
One table to bring them all
And in the darkness blind them…

…with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike!

Prep notes here

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06 May 202479. A Précis on Penicillin Binding Proteins00:32:33

Presenting: More on Penicillin-Binding-Proteins than you realistically ever need to know! 

  • What is the difference between Gram positive and negative bacteria's cell walls?
  • What is a Penicillin Binding Protein (PBP)?
  • Why are they called PBPs?
  • What do PBPs do?
  • What makes MRSA resistant to (most) beta-lactams?

These any many more questions answered!

Notion page here - you'll need it for this one, check it out! 

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20 May 202480. A Poem on POET00:06:07

Join us for this special 80th episode celebrating Jame's favourite trial.

https://www.nejm.org/doi/full/10.1056/NEJMoa1808312

Prep notes (including the images referred to in the poem) here

Special thanks to the Wikiguidelines Endocarditis crew for their work summarising the evidence this poem was based on. 

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03 Jun 202481. Microbiome 1: Introduction00:29:32

In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, returns to talk about her favourite subject! 

This episode is part 1 of 2. Here we discuss: 
- What is the microbiome
- Viewing the microbiome as an organ system
- The microbiome's association with disease
- How we study the microbiome

Stay tuned for part 2 (in 1-2 weeks depending on editing), when we talk about the effect of medicine on the microbiome, microbiotoxicity, and what you can do to keep your patients' microbiomes in tip top shape! 

https://www.researchgate.net/profile/Anastasia-Theodosiou

https://x.com/doctoranastasia

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17 Jun 202482. Microbiome 2: Microbiotoxicity00:45:04

In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, finishes educating Callum and Jame (mostly Callum) on the concept of Microbiotoxicity!

This episode is part 2 of 2. Here we discuss: 

- What is microbiotoxicity?
- Risk factors for microbiotoxicity
- Which antibiotics are associated with microbiotoxicity?
- Mitigating microbiotoxicity

https://www.researchgate.net/profile/Anastasia-Theodosiou

https://x.com/doctoranastasia

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10 Jul 202483. BSAC Spring Conference 202400:34:21

Jame was there but Callum wasn't! The British Society for Antimicrobial Chemotherapy have several conferences throughout the year, including a Spring meeting with their AGM. But what topics were discussed, I hear you wonder? WELL WONDER NO MORE: Jame'll take you through it!

Notes for this episode here

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22 Jul 202484. BIA Spring Meeting 202400:29:23

The Spring Meeting of the British Infection Assocation is a must for UK infection trainees; In this week's episode Callum summarises for Jame (who was there, but didn't take any notes) the main learning points from the meeting.

Show notes for this episode here

BIA membership is FREE to UK infection trainees, reasonably priced for everyone else, and paid memberships come with online access to the Journal of Infection! Sign up today at https://www.britishinfection.org/join

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05 Aug 202485. Bordetella and the Cough of 100 Days00:37:10

You'll be whooping with knowledge after listening to this one. Come hear all about Bordetella species. From pertussis to kennel cough you'll hear it all.

Show notes for this episode here

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23 Aug 202486. Legionella and pontiac fever00:35:10

Jame and Callum are joined by Lee John and Ella for this episode around the arch-villain of atypical pneumonia and the bogeyman of every spa. Yes Legionella pneumophila (and friends) are addressed in depth whilst this podcast is aerosolised around the world.

Show notes for this episode here

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30 Aug 202487. ID:IOTS guide to Tetracyclines00:28:40

Join Jame and Callum on this episode about the  ultimate 4 rings of power: Tetracyclines. The swiss army knife of antibiotics. We talk through the history, uses, mechanism, PK/PD and resistance.

Become a pharmacophile as you learn something about pharmacophores.

Shows notes for this episode here

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13 Sep 202488. Where are all the new antibiotics?00:23:04

Join Jame and Callum as they discuss this paper which examines where these new antibiotics are going, and why they aren't widely available.

Notes for this episode here

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30 Sep 202489. Moraxella catarrhalis00:14:57

Moraxella means more moronic puns from Jame&Callum. A short episode for some short rods. Listen to hear about this coccobacillus, how to identify it in the lab and what sort of clinical syndromes it causes.

Show note for this episode here

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14 Oct 202490. IV to Oral Switch00:19:34

In which Jame talks about the rationale for IVOS, evidence base for the pros and cons, and then finishes by giving the UK oral switch criteria an absolute rinsing.

Prep notes available here

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28 Oct 202491. The ID:IOTS Guide to Tetracyclines 2: Tigecycline, Eravacycline, Omadacycline00:38:15

They're new, they're weird, and we don't use them very much (or at all), but that won't stop your favourite ID:IOTS sounding off on these novel tetracyclines!

In this episode we discuss: An overview of the 3 drugs, including spectrum & penetrance; pharmacokinetics; EUCAST breakpoints; resistance mechanisms; and the recommendations for use in the IDSA DTR Gram Negative guidelines 2024.

Prep notes for the episode here

Got a question? Use the new 'send us a text' link in the episode description! 

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18 Nov 202493. World AMR Awareness Week special: The Scottish Antimicrobial Prescribing Group (SAPG)00:54:22

WAAW! This week, to celebrate World AMR Awareness Week, Callum is Joined by Andrew, Fran, Jo and Simon from the Scottish Antimicrobial Prescribing Group.

Listen in to hear all about SAPG and their important work, plus we discuss WAAW and what you can do to help tackle AMR.

Show notes for this episode here, including links to the resources mentioned.

Sign up to be an #antibioticguardian here.

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10 Feb 2025100. AST: Rapid Identification and Molecular AST. The BCID2 & Vitek Reveal with BioMérieux00:34:49

Jame is joined by Kate from BioMérieux as they take a deep dive into the BCID2 and the Vitek Reveal, 2 new devices used for rapid identification and antimicrobial susceptibility testing of blood culture isolates.

Note: This episode was produced in collaboration with BioMérieux. An honorarium received from them will be donated directly to charitable causes.

Message from BioMérieux: Every effort has been made to ensure the accuracy of information shared during our podcast appearances. The views expressed by our representatives are in good faith and based on the information available at the time. We accept no liability for any errors, omissions, or discrepancies. For the most accurate and up-to-date product details, please refer to our official website or contact us directly

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12 Nov 202492. AST: What is resistance anyway? (S/I/R)00:36:25

Have you ever looked at your microbiology lab report and wondered "What does resistant mean anyway?" 

We're sure you have (and if you haven't you should have)! And conveniently we've recorded this podcast episode to explain how it all works! We talk through the definition of S, I & R, plus some explanation on the science behind these letters.


This is the first in the new Antimicrobial Susceptibility Testing (AST) mini series. Make sure to listen to this one first!

Show notes for this episode here.

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02 Dec 202494. BSAC OPAT conference 202400:25:14

Jame regales Callum with tales of his online adventure to the BSAC OPAT conference. Listen in to hear some updates on: implementation of OVIVA; subcutaneous antibiotics; and the BSAC OPAT good practice guidelines

Notes for this episode here.

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27 Jan 202599. AST: Automated Identification & Sensitivities - the Vitek2 with BioMérieux00:26:37

This week Jame is joined by Nick and Dal from BioMérieux as they take a deep dive into the Vitek2, one of the machines available for performing Automated Antimicrobial Susceptibility Testing.

Note: This episode was produced in collaboration with BioMérieux. An honorarium received from them will be donated directly to charitable causes.

Message from BioMérieux: Every effort has been made to ensure the accuracy of information shared during our podcast appearances. The views expressed by our representatives are in good faith and based on the information available at the time. We accept no liability for any errors, omissions, or discrepancies. For the most accurate and up-to-date product details, please refer to our official website or contact us directly


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17 Mar 2025103. Fungal infections overview and series intro00:31:04

My my! Mycology?

Join Callum and special co-host Alyssa for this, the first in the all new ID:IOTS Mycology Mega-series.

Here we cover:

  1. What the British Society of Medical Mycology is and what they do 
  2. Why we're doing this series on fungi  
  3. The Global and UK Burden of fungal disease. 
  4. The spectrum of fungal disease clinically, 
  5. The taxonomy of these pathogens, 
  6. and the WHO Fungal Pathogen List.


Notes for this episode can be found here.

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09 Dec 202495. FIS 2024 part 1: AMR & Bacteria00:28:42

HO HO HO, MERRY FISMAS!!!

On the First Pod of FISmas these ID:IOTS have to you… a terrifying update on the Antibiotic Apocalypse!

Jame and Callum attended the Federation of Infection Societies 2024 annual meeting in  Liverpool; here they share their reflections on the sessions  they attended on: Bacteria and Antimicrobial resistance.

Episodes on viruses, fungi etc. coming soon!

Notes for this episode here

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16 Dec 202496. FIS 2024 part 2: Viruses00:23:13

HO HO HO, MERRY FISMAS!!!

On the Second Pod of FISmas these ID:IOTS have for you… an all-enveloping, capsidating update on the High Consequence Infectious Diseases, measles, RSV and other viruses that you ‘R naught’ going to want to skip! 

Jame and Callum attended the Federation of Infection Societies 2024 annual meeting in  Liverpool; here they share their reflections on the sessions  they attended on: Viral pathogens

Final episode on fungi etc. coming soon!

Notes for this episode here

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23 Dec 202497. FIS 2024 part 3: Fungi, NTM, quinolones and others00:20:06

 HO HO HO, MERRY FISMAS!!!

On the Third & Final Pod of FISmas these ID:IOTS have for you… 6 golden topics! Listen to hear about:
1. Personalised approach to invasive fungal infection
2. Agricultural anti-fungals and One Health
3. Candida auris
4. NTM standards of care
5. Narrative reporting
6. Fluoroquinolones and the MHRA warnings
 

Jame and Callum attended the Federation of Infection Societies 2024 annual meeting in  Liverpool; here they share their reflections on the sessions  they attended on:  a wide mix of topics

We hope these episodes have been ADVENTatious to your learning.

Notes for this episode here 

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06 Jan 202598. Meningitis Masterclass01:07:20

Jame and Callum are joined by Dr Fiona McGill, lead author of the 2016 Joint Specialist Societies Meningitis Guidelines.

Listen to hear an overview of the epidemiology, presentation, diagnosis and management of both bacterial and viral meningitis in the UK.

Show notes for this episode here

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24 Feb 2025101. AST: When there ARE breakpoints - how to use the EUCAST clinical breakpoints table00:15:56

BREAKPOINTS. We all love them. S breakpoints... R breakpoints... dash, IE, NA...

Wait, dash, IA, NA, Brackets?!

LISTEN ON (and read the accompanying prep notes), and soon you'll know! In this episode Jame and Callum talk through the EUCAST breakpoints table and how to interpret it

Show notes for this episode here

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03 Mar 2025102. AST: When there are NO breakpoints- how to use the EUCAST guidance document00:14:50

So now, Loyal Listener, you know all about Susceptible, Sensitive at higher doses, Resistant, MICs, ECOFFs/ECVs and how to use the EUCAST breakpoints table....

But what about the wild-west of bug-drug combos where there are no breakpoints?

Well in this episode, Jame and Callum talk through the EUCAST approach to this situation.

Show notes for this episode here

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07 Apr 2025104. Fungal Diagnostics part 1: Microscopy, Culture & Identification techniques00:50:39

Callum and Alyssa are joined by Professor Malcolm Richardson to talk about all things fungal diagnostics.

In this, part 1 of 2 on diagnostics we discuss the use of microscopy, histopathology and culture in diagnosing fungal infections.

Notes for this episode can be found: here.

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14 Apr 2025105. Fungal diagnostics part 2: biomarkers, serology and molecular00:45:22

Callum and Alyssa are joined by Professor Malcolm Richardson to talk about all things fungal diagnostics.

In this, part 1 of 2 on diagnostics we discuss the use of biomarkers such as beta-D-Glucan and galactomannan, as well as serology and molecular techniques.

Notes for this episode can be found: here.

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24 Mar 2025104. IDSA Difficult To Treat Gram negatives Guidance 2024 with Breakpoints podcast01:18:41

IT'S A BREAKPOINTS BREAKOUT!

Jame and Callum are joined by the drugnamic duo of Julie-Ann Justo & Erin McCreary from the Breakpoints podcast to delve into the IDSA DTR Gram negative Guidance.

Show notes for this episode are here.

Breakpoints podcast can be found here: https://breakpoints-sidp.org/


Lyrics: 

Tryin’ to use some drugs to kill these bugs

Erin and Julie are PK PD thugs 

Gonna make these two ID:IOTS look like mugs

It’s gonna be a Breakpoints Breakout


Sorry the song sounds so tinny, Podcast host is doing something strange to it. Link to original MP3 here

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

28 Jul 20211: It starts with Staph00:37:40

In the first episode of the ID:IOTS podcast Callum and Jame talk for longer than intended about everyone's favourite Gram positive coccus, Staphylococcus aureus.

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

04 Aug 20212: Streptococci demystified00:47:23

In the second episode of the ID:IOTS podcast Callum and Jame try to demystify the classification of Streptococci

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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11 Aug 20213: Clarifying Coagulase-Negative Staph00:31:28

What are the coagulase negative Staphylococci (CNS)? In this episode of the ID:IOTS podcast Callum and his Jame coalesce their clinical knowledge of coagulase negative Staphylococci

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Questions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

If you are enjoying the podcast please leave a review on your preferred podcast app!

Feel like giving back? Donations of caffeine gratefully received!
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17 Aug 20214: Completing cocci00:17:28

In this episode of the ID:IOTS podcast Callum and Jame talk about some other Gram positive cocci of clinical relevance (and sometimes irrelevance).

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

If you are enjoying the podcast please leave a review on your preferred podcast app!

Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

08 Sep 20215: Back to bacteraemia00:44:38

In this episode of the ID:IOTS podcast Callum and Jame go back to the patient bedside to discuss bacteraemia looking at definitions, how bacteraemia occurs, how to diagnosis a bacteraemia and some management considerations.

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Questions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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20 Sep 20216. Skin and Soft Tissue Infection00:37:44

Callum and Jame record a 'quick' episode on SSTI, which turned out to be so long we split into 2 parts! 

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

If you are enjoying the podcast please leave a review on your preferred podcast app!

Feel like giving back? Donations of caffeine gratefully received!
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22 Sep 20217. Necrotising Fasciitis00:18:33

Callum and Jame finish off their discussion of Skin & Soft Tissue infection by going over the assessment and management of Necrotising Fasciitis. 

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Questions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

If you are enjoying the podcast please leave a review on your preferred podcast app!

Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

29 Sep 20218. Pneumonia01:03:09

In this episode of the ID:IOTS podcast Callum and Jame continue looking at clinical syndromes mostly associated with Gram positive cocci by looking at lower respiratory tract infections/pneumonia. 

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Support the show

Questions, comments, suggestions to idiotspodcasting@gmail.com or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

If you are enjoying the podcast please leave a review on your preferred podcast app!

Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

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