Authentic Biochemistry (Dr Daniel J. Guerra)
Explorez tous les épisodes de Authentic Biochemistry
| Date | Titre | Durée | |
|---|---|---|---|
| 28 Jun 2021 | Detailing the Senescent to Mesenchymal Transition in Aging : Links to Cancer vs. Apoptosis. DJGPhD 28 June 2021. | 00:29:34 | |
Clinical and Molecular Allergy volume 15, Article number: 21 (2017) Front. Immunol., 25 September 2019 | https://doi.org/10.3389/fimmu.2019.02247 | |||
| 03 Mar 2025 | An immunological Framing of Neurotransmission. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra. 02MaRCH2025 | 00:21:52 | |
References Guerra, DJ. 2025 Neurohormonal Lectures Brief Introductions | |||
| 20 Oct 2021 | How Oxysterol LDL associates with macrophage and T lymphocyte infiltration during aging to generate the hyperinflammatory atherosclerotic plaque. DJGPhD. 19.10.21. Authentic Biochemistry. | 00:29:33 | |
That there are senescence-associated decreases in the JAK-STAT signaling transduction cascade has been observed in human lymphocyte lineages. This phenomena, as associated with a decreased JAK- tyrosine phosphorylation of STAT5, is linked to plasma membrane cholesterol content. Therefore, plasma membrane cholesterol content is involved in T cells modulation and proliferation. Acid sphingomyelinase- mediated ceramide lipid raft mobilization and aggregation of membrane receptors plays a crucial role in this pathobiochemical dynamic leading to multiple disease and comorbidity states in the elderly. Classical Papers Examined: Mech Ageing Dev. 2001 Sep 15;122(13):1413-30 Cytometry A. 2006 Mar;69(3):189-91 J Lipid Res. 2007 Jan;48(1):19-29. doi: 10.1194 | |||
| 21 Jan 2023 | A Special Message for Authentic Biochemists. A direct way to contact your host and a little more. DJGPhD.21.1.23 Authentic Biochemistry Productions. | 00:10:36 | |
Rather than referencing this episode I am enlisting your input. Please email me at our new email address: authenticbiochemistry@gmail.com
Sincerely, Dr Guerra | |||
| 26 May 2024 | Authentic Biochemistry Podcast. B-Cell Membrane Biochemistry.c.3. Dr. Daniel J. Guerra. 26.5.24 | 00:44:26 | |
References Cancer Science June 2014. 105(9) Acc Chem Res. 2021 May 4;54(9):2110-2120. Nat Immunol. 2022 Jan; 23(1): 99–108. . Bach, JS. 1704.Toccata and Fugue in D minor BWV 565 https://youtu.be/erXG9vnN-GI?si=o6YlpjXM2dRLpyZQ Leach, D. 1965"Catch the Wind" https://youtu.be/J8hjEYTpwE8?si=XeWU1HSy6CGBlEeT | |||
| 05 Jan 2025 | A priori Metabolic Architectonics I. Dr. Daniel J. Guerra 04January 2025. Authentic Biochemistry Podcast. | 01:01:49 | |
References Guerra, DJ.2025. Biochemistry general lecture. Immunol. Res. 2020. 68:28-38. J J Vis Exp. 2013 Nov 22;(81):50966. Anderson, I. 1969. "A New Day Yesterday" Jethro Tull [Stand Up. lp] https://youtu.be/Kq5zTznlSJI?si=rJkLP28p3T4-F4Qw Nestor, Armatrading. 1972. "Visionary Mountains" MMEB {Nightengales and Bombers.lp] https://youtu.be/z1zzeAttCCc?si=7IRveShgMwTn0CJ8 Mozart,WA. 1783. String Quartet K 421 in D Minor https://youtu.be/QLHDRzv2VzQ?si=sfhG07rO2ojQv-J-
| |||
| 29 Apr 2022 | Cytoepigenetics V. Small interfering and micro RNA mediate mitochondrial and nuclear transcripts thus rendering cell fate, bioenergetics, and immunogenicity. DJGPhD.29.4.22. Authentic Biochemsitry | 00:29:54 | |
References Guerra lecture notes/ideas Genes (Basel). 2014 Dec; 5(4): 865–886. Molecular Therapy—Nucleic Acids (2015) 4, e252 Int. J. Mol. Sci. 2016, 17(5), 719 | |||
| 20 Feb 2020 | Dr Guerra examines Sphingolipids as mediators of Inflammasome Formation and Potency in Coronavirus | 00:27:52 | |
In this Authentic Biochemistry Podcast, Dr. Dan Guerra explains the roles of acid sphingomyelinases and associated ceramide production on the NLRP3 inflammasome activation as linked to coronavirus pathogen molecular patterns and the production of proinflammatory cytokines 19 February 2020. | |||
| 13 Oct 2024 | Sarcopenia XVII Fine. Authentic Biochemistry Podcast. 12October 24 Dr Daniel J. Guerra. | 00:55:24 | |
References Am J Physiol Cell Physiol 2019 Sep 1;317(3):C502-C512 Browne, J. 2002."Dont You Want to be There?" https://open.spotify.com/track/2e62rpQnEaVoQHWltXWDVV?si=8ba86ab27eeb4972 Simon, P. 1970. "The Boxer" https://open.spotify.com/track/76TZCvJ8GitQ2FA1q5dKu0?si=db43bb95e8504819 Biber, HIF von. 1681. Sonata 8 https://open.spotify.com/track/56hzAmdRl7ndN95YFeksUQ?si=0128734522544c1e | |||
| 24 Sep 2021 | REDOX Biochemistry Primer . DJGPhD Authentic Biochemistry . 24.9.21 | 00:28:37 | |
Oxidases, dehydrogenases and oxygenases in the electron transport chain et al. | |||
| 17 Jun 2024 | Immune Cell Biochemistry. B cells C.12. Epigenetic Regulation. Dr Daniel. J. Guerra.17.6.24.Authentic Biochemistry Podcast | 00:43:41 | |
References Cell. 2021 Apr 1; 184(7):1790–1803.e17. NAR Cancer. 2024 Jun; 6(2):zcae023. Peretti, Creatore, and Weiss. 1961. "Cant Help Falling in Love". Elvis Presley. https://youtu.be/O-aavAlSYgc?si=yEHWfI2Ny-zvQLnK Lennon-McCartney. 1965. "Wait" Rubber Soul lp. https://youtu.be/qJngWval8Bc?si=CRTQilYzdVZxAtSe Mozart. WA .1788. Divertimento in E Major. K.563. https://youtu.be/E8c83bpOVXo?si=EBffyTWZz0xHZqYs
| |||
| 25 May 2023 | ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency. | 00:30:00 | |
References Journal of Experimental & Clinical Cancer Research 2022.volume 41, Article number: 303. Protein Cell. 2021 Apr; 12(4): 240–260. J Cell Biol (2022) 221 (11): e202202011. | |||
| 18 Oct 2023 | BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast | 00:30:00 | |
References Brain. 2023 Sep 13:awad309. doi: 10.1093/brain/awad309 J Alzheimers Dis. 2016 Feb 26;52(1):43-50. Haydn, FJ. 1796. MISSA IN TEMPORE BELLI https://youtu.be/8_5tgmAwN-E?si=AYzyMMk47b2IUt0Y Send an email to Dr Guerra! authenticbiochemistry@gmail.com | |||
| 12 Jul 2020 | Neutrophil Elastase and the extracellular trap mediated hyperinflammatory response leading to pulmonary edema, Na+ hyperabsorption: linkage to coronavirus . | 00:28:41 | |
The synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascular disease, diabetes and lung dysfunction pre-dispose to viral infection and illness. Published 11 July 2020. | |||
| 21 Nov 2023 | BioMedical Portrait VI.c.8.The cytotoxicity of the NK cell Is a function of its bioenergetics. Glycolysis/OXPHOS vs. FAO/OXPHOS during activation/proliferation | 00:29:51 | |
References Front Immunol. 2023; 14: 1151166. Inflammation Research :official journal of the European Histamine Research Society 2018.1420-908X, Vol. 67, Issue 10. J Cell Sci. 2011 Dec 15; 124(24): 4147–4159. Hunter, R. and J. Garcia 1970. "Sugaree" https://music.youtube.com/watch?v=sxF9UJ-Rm0E&si=S4F0LvlFvUsTE1OO | |||
| 31 Jan 2025 | A priori Metabolic Architectonics XIII. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra.30JAN25 | 00:47:08 | |
References Nature 2024. 633:451.August Antioxid Redox Signal. 2010 Mar 15;12(6):703–712. JBC 2018. 293: 2422-2437. JBC. 2005 Dec 2;280(48):40012-24. Payne and George. 1970. "Truck Stop Girl." Byrds Untitled lp. https://open.spotify.com/track/1i3qwxIOIqc7UyTQKdjtnf?si=d774d733d85349c1 McGuinn, R. 1969. "Ballad of Easy Rider" https://open.spotify.com/track/3Uel0UHGHz564BrHmwoWYZ?si=c2bbb4d33828420d Mozart, WA. 1787.Don Giovanni Overture K527 https://open.spotify.com/track/7JINUFIVIptR7hlQYayU3h?si=b648ec58cd1f4e19
| |||
| 16 Jan 2023 | Epistemological integration into realized metaphysicsV. Energy and mass like space and time are estimations of uncertain certainties yet are used as universals in physico-chemical event ontologies | 00:30:00 | |
References Thomas Hobbs-Leviathan Heraclitus-Collected Works | |||
| 05 Nov 2024 | Authentic Biochemistry Podcast. PTM's VII. The Integration of metabolism is engraved posttranslationally on proteins organized to conduct cellular reorganization and fate. DJGPhD. 05 November24 | 00:52:46 | |
References BMC Biology 2019. 17:52 Guerra, DJ. 2024. lecture material Key, F.S. 1814. American Anthem. https://youtu.be/PhShbVVQ49A?si=w3SoNzFYgbemMbyV Driftwood, J. 1936. "Battle of New Orleans. https://youtu.be/mjXM6x_0KZk?si=k4iQoKj52-ke_vlK | |||
| 01 Feb 2023 | A Biochemical Partita 3rd movement. Principle of Sufficient Reason and the refutation of biological reductionism. DJGPhD.31.1.23. Authentic Biochemistry Podcast Productions | 00:28:47 | |
Inspirations https://youtu.be/XkfsGCIiHb4 | |||
| 02 Dec 2022 | Membrane Biochemistry 86/Immunoepigentics1. The complex divergent roles of Inhibitor of DNA (Id) binding proteins in terminal differentiation and disease states. DJGPhD.01.12.22.Authentic Biochemistry | 00:30:01 | |
References Cell Reports Volume 17, Issue 11, 13 December 2016, Pages 2827-2836 Cardiovascular Research, cvac159, https://doi.org/10.1093/cvr/cvac159.Published:27 September 2022 Cancer Med. 2012 Oct; 1(2): 176–186. Nat Immunol. 2011 Nov 6; 12(12): 10 Nat Immunol. 2014 Aug; 15(8): 767–776 Stem Cells. 2007 Feb;25(2):500-10. | |||
| 26 Feb 2022 | Diabetes III. Sphingosine 1-Phosphate in glioblastoma and prostagladin E2/EP4 in diabetic nephropathy-an axis of angiogenesis. Dr. Daniel J. Guerra. 25.2.22 Authentic Biochemistry | 00:29:59 | |
References Journal of Biological Chemistry.2013. 288 Issue 52 Pages 37355-37364. Prostaglandins & Other Lipid Mediators. 2022(April) . Volume 159, 106621 | |||
| 08 Jan 2023 | ImmunoepigeneticsXIII. The interplay of NFKappB and articular cartilage glycosaminoglycan metabolism in regulating pro-inflammatory cytokine expression in OA. DJGPhD.Authentic Biochemistry. 08Jan2023 | 00:29:17 | |
references J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161 Connect Tissue Res. 2017 Jan; 58(1): 49–63. | |||
| 31 May 2020 | Dr Guerra's second lecture on T2D and its link to Obesity plus a bonus Clinical Misdiagnosis Study Question Review. 31 May 2020 | 00:28:24 | |
A brief concluding lecture on the linkage of obesity with Type 2 diabetes plus a clinical case study discussion and review question of a mis-diagnosis via anchoring. | |||
| 18 Aug 2023 | Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP. | 00:29:54 | |
__ [Mol Neurobiol] 2020 Jun; Vol. 57 (6), pp. 2654-2670 Oncol Rep. 2023 May;49(5):93 | |||
| 15 Jul 2023 | ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry. | 00:29:59 | |
Reference Nature Immunology 2022. volume 23, pages 1208–1221. | |||
| 01 Sep 2020 | Innate Like Lymphocyte and T Regulatory Cell Modulation against a backdrop of Immunostimulatory Effectors 01 September 2020. | 00:25:58 | |
Dr Guerra builds the foundation for transcription factor and epigenetic regulation of Treg cell differentiation in counterbalance to ILC's and T effector lymphocyte populations. Published 01 September 2020. | |||
| 04 Jan 2022 | The Motor Neuron Association to Reward Pathway: Motor Neuron Disease , an Introduction. Dr. Daniel J. Guerra. 03 January 2022. Authentic Biochemistry Productions. | 00:29:56 | |
Introduction to motor neuron structure/function relationships and the MND's including Amyotrophic Lateral Sclerosis. | |||
| 30 Oct 2024 | Authentic Biochemistry Podcast. PTM's V. Unique Autocatalytic Cholesterylation of a HedgeHog Signaling GPCR. Dr Daniel J. Guerra 29OCTOBER24 | 00:59:54 | |
References Biomolecules. 2020 Jul 7;10(7):1008. FEBS Lett 2021.595, Issue8. Pages 1107-1131 Cell Res. 2022 Mar 2;32(4):327–328. Cell Chem Biol.2024 Jul 18;31(7):1264-1276.e7. https://youtu.be/T5FN06LFfHk?si=RgFd7kBKAAJ6YKK0 Hunter&Lesh1970 "Box of Rain" on [American Beauty] lp. https://youtu.be/nxjvo4BRf-Y?si=e9MyF6FdLM2ylZaG Schubert, F. 1826. (Liszt Variation thereof.). ""Standchen.D889. https://youtu.be/9h35VSz2Kkc?si=ch4W4TX9iefj0t1C
| |||
| 06 Apr 2025 | An Immunological Framing of Neurotransmission XVIII Authentic Biochemistry Podcast Dr Daniel J Guerra 06April25 | 01:09:04 | |
References Glia. 2023 Nov;71(11):2679-2695 Cell 2015. 160.6: 1061-1071. March 1 Plant Signal Behav. 2017 Jan 19;12(2):e1282022.J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Dec 31;877(26):2696–2708. Lennon/McCartney ;Harrison. 1965. "Rubber Soul" https://music.youtube.com/playlist?list=OLAK5uy_lirCIxLpU2odTVLZ_Sbo1wZaeu5IStivs&si=N74HgIimStlNlTEj QMS. 1968. "Happy Trails" https://music.youtube.com/playlist?list=OLAK5uy_k8UyBDJcEQEHx90leh0EQN9STmouMbuDg&si=WZcMR7h1PPCCpX7R | |||
| 04 Sep 2019 | Dr Guerra provides an in-depth interrogation of lipid metabolism of omega three fatty acids and their complex roles in controlling inflammation. | 00:27:45 | |
Authentic Biochemistry's Dr Daniel Guerra implements his keen understanding of lipid metabolism to uncover the network of cellular, subcellular and pathway domains regulating fatty acid oxygenation and both glycerol-and sphingosine- lipid signaling that function to mediate cell fate and the inflammatory response in relation to dietary omega three fatty acid. 04 Sept 2019. | |||
| 12 Jan 2024 | BioMedical Portrait VIII. c.9. Initial detail of the LOX vs.COX isoform utilization of essential and other dietary PUFA's in complex leukotriene biosynthesis. DJGPhD.11Jan24.Authentic Biochemistry. | 00:30:00 | |
References British J of Pharmacology 2015. Volume172, Issue17September Pages 4319-4330 Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726.
| |||
| 19 Jun 2020 | Dialectical Event Ontological Analysis of the Scientific Method as Prolegomena to a Recap of PEDF in Hepatocellular Carcinoma | 00:28:21 | |
In this Lecture I define and then implement a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer pathobiochemistry. Published 19 June 2020 by Dr Daniel Guerra | |||
| 20 Feb 2025 | Authentic Biochemistry Podcast A priori Metabolic Architectonics XXII Dr Daniel J. Guerra 19FEB25 | 01:04:49 | |
References Cell Metab.2024.Volume 36, Issue 4p839-856.e8April 02, Acta Neuropathol.Commun. 2014 Jan 23;2:9 Guerra, DJ.2025. Unpublished lecturesTownsend. P. 1971 "Im in Tune" The Who. https://open.spotify.com/track/5f1FPGE3TsecMHZB8f8qQ1?si=8668113a4c3549ee Hunter/Garcia/Lesh. 1969. "St Stephen" Aoxomoxama Grateful Dead. Lennon/McCartney 1967. "Hello Goodbye"https://open.spotify.com/track/0vZ97gHhemKm6c64hTfJNA?si=9f938e5357724d8d | |||
| 26 Jul 2020 | The triad of biological auto-oxidation and the progress of aging as sine qua non to pathology. Published 26 July 2020. | 00:29:21 | |
Dr Guerra explains chain initiation, propagation and termination during lipid oxidation and the REDOX reactions of the electron transport chain as a lead in to enzymatic oxidations and the plasticity of immune linked senescence. 26 July 2020. | |||
| 15 Feb 2025 | A priori Metabolic Architectonics XX. Authentic Biochemistry Podcast. Dr Daniel J. Guerra.14FEB25 | 01:08:14 | |
References Maxwell, JC. 1873. A treatise on electricity and Magnetism I. Oxford. Acta Neuropathol Commun . 2014 Jan 23;2:9 J Neurosci. 2012 Dec 5;32(49):17909–17920. Guerra, DJ 2025 Unpublished lectures Mozart, WA. 1791."Ave Verum Corpus transcribed by Liszt. https://open.spotify.com/track/696mXatDdT9KNJ7qKbaqGj?si=821c45a65bc948e3 | |||
| 13 Jan 2023 | ImmunoepigeneticsXVI. TGFbeta 1 and subfamily member Activin A diferentially alter the categorical valence and modality of Th17 cells in multiple sclerosis via receptor kinase modulatory specificity. | 00:30:00 | |
References Immunity. 2021 Feb 9; 54(2): 308–323.e6. J Endocrinol. 2003 Sep;178(3):479-89. | |||
| 12 Aug 2024 | AD and Sphingolipids c.5 Sphingomyelinase and Ceramide molecular heterogeneity in AD is associated with bioenergetics and Ketone availability. Authentic Biochemistry. 11Aug24 Dr. Daniel J. Guerra | 00:57:31 | |
References EBio Medicine. 2015 Dec; 2(12): 1888–1904. J Atheroscler. Thromb.2023. Dec 1; 30(12): 1751–1758. Russian Orthodox Voices: https://youtu.be/z_M6YbsmT-I?si=l-U5ZwH90oCBbwAR | |||
| 09 Jan 2024 | BioMedical Portrait VIII.c.7. Differential control over fatty acid oxygenation and PPAR/RXR heterodimer pairing in mammalian uterine cell estrus physiology.DJGPhD.8Jan2024 | 00:30:00 | |
References General and Comparative Endocrinology,2018-06-01, Volume 262, Pages 27-35 Pisendel JG 1735.Violin Concerto in D major, JunP I.5. https://youtu.be/dvwhXXvFiNg?si=YfS2waKLC5WHy0En | |||
| 07 Aug 2023 | BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection. | 00:29:59 | |
References Essays Biochem. 2021 Nov; 65(6): 913–925 Front. Endocrinol. 2022. AUGUST. v.13 .Sec. Molecular and Structural Endocrinology
| |||
| 26 Sep 2023 | BioMedical Portrait III. c10. Ribosomal collision frequency is attenuated by ZAK and GCN2 via mutually exclusive signalling events, DJGPhD. 25.9.23. Authentic Biochemistry Podcast | 00:29:17 | |
References Cell. 2020 Jul 23; 182(2):404–416.e14. Curr Genet. 2021 Feb; 67(1): 19–26. RNA Biol. 2023; 20(1): 737–749. published online 13sept23 | |||
| 21 Jan 2023 | Immunoepigenetics XX. Inflammatory cytokines and associated transcription factors are controlled by epigenetically regulated microRNA. DJGPhD.20.1.23. Authentic Biochemistry. | 00:29:49 | |
References Dr Guerra's micro RNA lectures FEBS J Volume278, Issue10 May 2011. Pages 1598-1609 International Journal of Molecular Sciences 2013. 14(11):22796-22816 Front. Genet., 07 September 2021 | |||
| 04 Dec 2023 | Bio Med Portrait. c.16. NK cells promote the inflammatory court in NAFLD via mutations in lipid metabolism and excessive GK mediated glycolysis and lipogenesis in hepatocytes DJGPhD.3Dec23b | 00:29:40 | |
References Front. Immunol., 21 August 2019 Sec. Cancer Immunity and Immunotherapy Volume 10 Front Immunol. 2021; 12: 640869 PLoS One. 2014; 9(2): e87523 Vivaldi, A. 1719. "L 'inverno". https://youtu.be/pCqO-0339k0?si=k5xtuT8x7SfJeLok | |||
| 27 Jul 2023 | ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD | 00:29:30 | |
Reference Cancers (Basel). 2021. Apr; 13(8): 1850. | |||
| 20 Apr 2021 | The immune system is both genetically programmed and environmentally adaptable to epigenetic states. Lecture II DJGPhD 19 April 2021 | 00:29:44 | |
Neuroinflammatory mediators play a critical role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. These processes occur throughout life and involve the immune system, biochemical pathways, cellular turnover and alteration of gene expression. Signal transduction cascades allow for genome editing to epigenomic mediation of metabolic event ontologies. Aging is a process whereby these processes lose specificity and valence, increasingly functioning without appropriate fine control leading to the potential for chronic and more rarely, acute disease states that ultimately result in mortality | |||
| 09 Sep 2023 | BioMedical PortraitII. c13. Female prevalent autoimmune RA-macrophage STAT3(TF) and NaMPT(NAD+ salvage pathway) promote rheumatoid arthritis & primer on thyroiditis | 00:30:00 | |
References Cells. 2022 Mar; 11(6): 997. Nat Cell Biol. 2019 Mar; 21(3): 397–407. Rheumatology (Oxford). 2023 Jul; 62(7):2611–2620 | |||
| 05 Apr 2022 | Diabetes XXVI. Adipogenic and hypertrophic adiposity differentially control dyslipidaemia and Insulin resistance in association with pro-inflammatory cytokine induced T2D and breast cancer.DJGPhD. | 00:29:55 | |
References Dr. Guerra's lipid lecture notes Cancer Res. 2018 Apr 1; 78(7): 1713–1725. Progress in Lipid Research Volume 74, April 2019, Pages 145-159 | |||
| 26 May 2022 | CytoEpigenetics XIV. The details of AMPK mediated control over DNA methyl transferase thus coordinating bioenergetics with cell fate via the epitranscriptome. DJGPhD. 25.5.22 | 00:29:57 | |
References Dr. Guerra's synthesis of the epitranscriptome lecture notes Sci Signal. 2017 Jan 31; 10(464): eaaf7478. | |||
| 10 Oct 2023 | BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD | 00:29:23 | |
References Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74LR2JY The EMBO Journal (2022)41:e109108 PLoS ONE 2013. 8(6): e65646. doi:10.1371/journal.pone.0065646 Molecular Neurodegeneration 2022. volume 17,Article number: 73 | |||
| 04 Jul 2022 | Membrane Biochemistry XII. The specificity of membrane lipid raft molecular species and the dialectics of protein sorting. DJGPhD.3 July 2022 Authentic Biochemistry. | 00:29:48 | |
References Dr. Guerra's notes The Journal of Nutrition, Volume 137, Issue 3, March 2007, Pages 548–553 Front Immunol. 2019; 10: 1309. Int J Mol Sci. 2019 Oct 11;20(20):5028 | |||
| 18 Apr 2021 | The Immuno-Epigenome Contribution to Aging Foundation Lecture I. DJGPhD 18.4.21 | 00:29:42 | |
An Introduction to the theory of immunoepigenetic tailoring of human instanence. Dr. Guerra Authentic Biochemistry Podcast Studios | |||
| 01 Jul 2024 | Immune Cell Biochemistry.Authentic Biochemistry Podcast Multiple Myeloma Dyslipidaemia. B cells lecture c.15 Fine(a) 30.6.24 Dr Daniel J. Guerra. Authentic Biochemistry. | 00:52:19 | |
References Clin Exp Med. 2023; 23(7): 3373–3390. Blood Cancer J. 2024 Dec; 14(1): 24. Archivum Immunologiae et Therapiae Experimentalis. 2013 .Apr;61(2):119-25. Int. J. Mol. Sci. 2019, 20(6), 1505. Winkelmann, B. 1970."Good Morning" Steve Miller Band V. https://youtu.be/RhI-46SbsDk?si=ovfiAZREgBKUBOBw Lennon-McCartney. 1967. "Good Morning" Beatles. Sgt. Pepper's Lonely Hearts Club Band. https://youtu.be/sjb9AxDkwAQ?si=lK_S8CJ8sfeYil3g Saint-Saëns, C. 1886.Symphony No 3 in C minor, Op 78 https://youtu.be/ZWCZq33BrOo?si=SFRkBG517Da2ceST
| |||
| 23 Feb 2024 | Biochemical MosaicI.c.13 Phosphatidic acid as key lipid intermediary of membrane secretion signalling and cellular intracommunication via kinase cascade and transcriptional regulation.DJGPhD.22.2.24 | 00:29:55 | |
References Biomedicines 2023, 11(7), 1804 BMC Biology. 2011. 9:85 Cancer Res. 2011 Jan 15;71(2):293-7. FEBS Lett.2019.593.17:2428-2451 Verdi, G. 1841. Nabucco Overture https://youtu.be/OseGETWEnCo?si=LhiIQV-N0-_Z_s-s Lennon&McCartney. 1966 "For No One". Beatles: Revolver. https://youtu.be/sep5E3ssXLQ?si=WLtMrP-Xq279qZXl | |||
| 07 Dec 2023 | BioMed Portrait VII. c.2 Lipoprotein lipase mediated TAG delivery and adolescent obesity. DJGPhD.6Dec23. Authentic Biochemistry | 00:29:33 | |
References Clin Chim Acta . 2020 Sep:508:61-68 Applied Physiology, Nutrition, and Metabolism.2021. Volume 46, Number 8. | |||
| 08 Apr 2022 | Diabetes XXVIII. Diabetic nephropathy is a consequence of non-esterified free fatty acid associated ceramide induction of the IRS-1 phosphorylation in glomerular podocytes inducing inflammation | 00:30:00 | |
| 27 Dec 2021 | AMPK and Immuno-Epigenetic Biochemistry Part 1. Dr. Daniel J. Guerra. 27.12.21. Authentic Biochemistry | 00:29:59 | |
References Nat Cell Biol. 2019 Mar; 21(3): 397–407 CELL Volume 126, Issue 3, 11 August 2006, Pages 503-514 Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Int J Biol Sci. 2015; 11(11): 1272–1280 Sci Signal. 2017 Jan 31; 10(464): eaaf7478. Front Immunol. 2019; 10: 345. J Neuroinflammation. 2019; 16: 34. | |||
| 27 Sep 2020 | Is cancer. or survival-achieving chemotherapy to treat early-onset tumorigenesis, linked to late in life senescence and human aging? The CD8+ T lymphocyte link. | 00:22:08 | |
A take-home message from this research may be that the immunosenescent phenotype in the elderly, while associated with an increased rate of infections and a diminished effect of vaccines, and increased cancer susceptibility may be promoted by cancer and /or chemotherapy to cure the cancer. Both cancer and chemotherapy contribute to immune compromise and potential for gene mutations and epigenetic phenomena. | |||
| 02 Jan 2023 | Epistemological integration into realized metaphysics III. Mensam de phaenomenus and the concept of evidentiary existentialism in research science. DJGPhD.01Jan23.Authentic Biochemistry. | 00:29:40 | |
References Anaximander 6th century B.C. Plato-Timaeous 4th century B.C. Kant 1781 Critique of Pure Reason Basic quantum physics notes Dr Guerra Neuroscience lectures
| |||
| 24 May 2023 | Graduate Biochemistry Lecture III. Dietary lipid control over neuroendocrine system involves multiple organ systems in contact with immune surveilance. DJGPhD. 24.5.23B Authentic Biochemistry | 00:29:53 | |
References Dr. Guerra's lecture archives. | |||
| 05 Jun 2023 | ImmunoEpigenetics74.The methylation-specific epigenetic control over adipose tissue macrophage polarity is axially supported by leptin induced CNS control over satiety and pancreatic insulin secretion | 00:30:00 | |
References JCI Insight. 2016 Nov 17; 1(19): e87748. Graduate Biochemistry lecture archives-Guerra Nutrition. 2020 Oct;78:110935. | |||
| 26 May 2020 | Nutritional biochemistry and the obesogenic induction of insulin resistance and type-2 diabetes. Dr Daniel J. Guerra. 25 May 2020 | 00:29:08 | |
Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease. 25 May 2020b. | |||
| 04 Mar 2025 | An immunological Framing of Neurotransmission II Authentic Biochemistry Podcast. Dr. Daniel J. Guerra. 03MARCH2025 | 00:50:34 | |
references Guerra DJ 2025. General Immuno-Neurobiochemical lectures Plant&Page. "Rain Song" LZIV. https://open.spotify.com/track/3JLrri1xSCui3bzITDJbkk?si=c4ff9d466c2d455f Hunter/Garcia. 1970 "Attics of my Life" American Beauty lp. GD https://open.spotify.com/track/6WeLHc9eLjVJqOKhd97vaK?si=efeead325f094519 Schubert F. 1828. Piano Sonata in B flat Major. #15. D960 https://open.spotify.com/track/7H3UCOtOQhmvKaC3QA0h7p?si=312dc808cbf64a5b | |||
| 25 Dec 2023 | Christmas Eve Special:Research science relies on the means by which it is apprehended thus continuously challenged and improved with the goal of finding truths about nature in perpetuity.DJGPhD | 00:27:51 | |
References Guerra's epistemology and metaphysics :brief sketch Baroque Christmas Concert with works by Bach, Handel and Mozart Freiburg Baroque Orchestra https://youtu.be/3VupBizhIn4?si=jBOcxwesBtMPv_I1 | |||
| 16 Jun 2023 | ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast | 00:29:50 | |
References J Biol Chem 2017 292: 20481. Critique if Pure Reason.1781. Kant,I. Guerra,2023. manuscripts in preparation | |||
| 08 Jun 2019 | HCC Episode VII. Dr Guerra tackles the pathogenecity of the serine proteinase inhibitor paradigm . 08 JUne 2019 | 00:28:08 | |
Serine proteinases and their peptide inhibitors, the SERPINS, have a role to play in liver pathology and disease potentiation leading to subcellular protein aggregation, enhanced inflammation and ultimate hepatocellular carcinoma. Dr. Guerra of Authentic Biochemistry introduces this new plank in the knowledge platform being constructed to apprehend either the necessary or sufficient conditions in HCC. | |||
| 02 Mar 2023 | ImmunoEpigenetics XXXVII. Differential substrates for the Adenylate Cyclase-PKA phosphorylation cascade distributes assymetric inflammatory, hormonal and metabolic sequalae. DJGPhD.01March23. | 00:29:38 | |
REferences Dr Guerra's graduate biochemistry lectures J Biol Chem. 2013 Mar 8; 288(10): 7137–7146 | |||
| 23 Dec 2022 | Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB. | 00:30:00 | |
References Neural Plasticity. 2019; 2019: 1648736. Molecular Pharmacology May 2017, 91 (5) 451-463. | |||
| 21 Dec 2022 | Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast | 00:21:15 | |
References Dr Guerra's ideas and concepts concerning the epistemics of research science . Lecture I. | |||
| 31 Dec 2021 | Anhedonic and MDD- Associated Appetitive Reward Pathway Biochemistry and Pathophysiology II. DJGPhD. Authentic Biochemistry.30..12.21. | 00:29:50 | |
References Front Neurosci. 2019; 13: 707 Nature Metabolism 2019. 1:754–764 Int. J. Mol. Sci. 2019, 20(6), 1505 Neuropsychiatr Dis Treat. 2015; 11: 875–888 Mol Psychiatry. 2016 Oct; 21(10): 1358–1365. | |||
| 10 Jan 2022 | Avirulence in the Streptococci and the Two-Component System of Histidine Kinase and Response Regulator. II. DJGPhD. Authentic Biochemistry 09Jan2022 | 00:29:57 | |
References Front. Microbiol., 14 July 2021 PLoS One. 2016; 11(11): e0166656. The Lancet Microbe 2021; 2(7) Pages e291-e299 | |||
| 06 Mar 2024 | Biochemical Mosaic II.c.6 Meduloblastoma is linked to plasmalogen and circ RNA phenomena that are pathophenocopied in other cancers. DJGPhD.5.Mar24.Authentic Biochemistry | 00:30:00 | |
References Acta Neuropathologica Communications 2023. volume 11, Article number: 38 Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7792–7798. Int J Med Sci. 2022; 19(6): 975–985 Nature Communications 2022. volume 13, Article number: 1508 Lassus. O. 1578. Requiem - Missa pro defunctis (4vv) : Offertorium | |||
| 17 Feb 2025 | A priori Metabolic Architectonics XXI. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra.16FEB25. | 01:05:10 | |
References Cell Metab. 2024. 36, Issue 4.2 Apri. Pages 839-856. Mol Neurobiol.. 2022 Mar;59(3):1882-1895. Mason, D. 1970. "Sad and Deep as You" Traffic. https://music.youtube.com/watch?v=f01g6PcyPrU&si=I0-_URHB13nNLpKE Miller, S. 1977. "Wintertime" https://music.youtube.com/watch?v=HUv7pXgZ9NA&si=T_aWVvAYkq9YlrHA Bach,JS. 1741. "Goldberg Variations" https://music.youtube.com/watch?v=wuY20YN6F4k&si=deW1je-H3XgcNDI1 | |||
| 22 Oct 2024 | Dolichol-PP Driven ER Glycosyl PTM’s Authentic Biochemistry Podcast Dr. Daniel J. Guerra 21October24 | 00:54:02 | |
References Clin Biochem. 2007 Jun;40(9-10):575-84 Endocr Metab Immune Disord Drug Targets. 2023;23(2):235-241. Guerra, DJ.2024. Lectures. Welch, R. 1971. "Future Games" Fleetwood Mac https://open.spotify.com/track/021JldNpXGATNSC69edcBT?si=0f29d7047e9d4eb0 Vivaldi, A. 1723. "Autumn" https://youtu.be/Z21_VpNipfg?si=ZXVDkCSFUz-JbhrE | |||
| 20 Jul 2023 | ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23 | 00:29:59 | |
Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579. | |||
| 17 Mar 2024 | Biochemical Mosaic II.Book 2. c.12 Adduced mTORC mediated glycerol-sphingolipid enzyme mRNA transcriptome association with Plasmalogen apodiction of myelination.DJGPhD.16.3.24 | 00:29:45 | |
References Developmental Cell 2022. Volume 57, Issue 6, 28 March Pages 691-706 Cell Rep. 2014 Feb 13; 6(3): 541–552. Dr Guerra: graduate lecture notes Mozart, WA 1791.Requiem in D Minor, K 626 https://youtu.be/YaH3zI0bYkM?si=X1yv50zY6nKTZmV9 Lennon/McCartney.1964 "I Don't Want to Spoil the Party" https://youtu.be/zqVDvLDLsjI?si=K1ve_5zJLZjqclsb | |||
| 04 Oct 2020 | Dr. Guerra finds that the tumor-promoting and suppressing biochemical phenotypes of senescence are phenomenologically contrarion and thus physiologically compatible | 00:29:03 | |
Lipids, proteins carbohydrates and nucleotides-may function within an inflammatory and secretory modality. Thus, the SASP-Senescence-Associated Secretory Phenotype might deliver apoptosis, necroptosis, autophagy, oncogenesis or an extended senescence sequalae. An Authentic Biochemistry audio lecture podcast by Dr. Daniel J. Guerra. 04 October 2020. Please SUBSCRIBE , check out my video lectures ( https://www.youtube.com/channel/UCcEoA2N9WSlNvDk1BtuznfQ?view_as=subscriber) and donate! https://podbay.fm/p/authentic-biochemistry Grazie! Dr. Guerra Nature Reviews | Cancer Reviews 19 | AUGUST 2019 :pp. 439 Nature Communications Vol. 9, Article number: 1228 (2018) doi:10.1038/s41467-018-03566-5 Front. Genet., 12 March 2015 https://doi.org/10.3389/fgene.2015.00094 | |||
| 12 Jan 2022 | Avirulence protein factor heterogeneity in multiple mammalian host/pathogen interactions. Dr. Dan Guerra. Authentic Biochemistry Production.11.Jan.2022 | 00:29:50 | |
References International Journal of Pharmacy and Pharmaceutical Sciences 2015 7(9):20-29 PLoS One. 2016; 11(11): e0166656. PLoS Pathog. 2019 Nov15;15(11):e1007687 Clin Microbiol Rev. 2006 Oct;19(4):728-62 Expert Rev Vaccines. 2009 Apr;8(4):447-54 Front. Microbiol., 14 July 2021 | |||
| 04 Dec 2024 | Authentic Biochemistry Podcast. Cell Surface Mediated Enzyme Regulation IX. CD8+TCell Immunosuppression. Dr Daniel J. Guerra. 03Dec24 | 00:53:27 | |
References Nature 2024.volume 635, pages 1010–1018 Front. Immunol. 2024. Sec. Multiple Sclerosis and Neuroimmunology Volume 15. J Immunol 2017. 199 (3) 874-884. Hunter-Garcia.1970 "Cumberland Blues" on Workingman's Dead https://open.spotify.com/track/2op5szd2IY8bOPzumqmFY3?si=8e3061b4559a4a31 Mozart. WA. 1791. Clarinet Concerto in A K 622 https://open.spotify.com/album/5WZELp7jlJNdS2xgLRknwe?si=ROhHJdu2RWCIpqnL7KXFUg | |||
| 03 Jun 2021 | Immuno Endocrine Regulation of Metabolism May-June 2021. Dr. Dan Guerra Authentic Biochemistry. | 00:29:42 | |
Feng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020 Molecular Neurodegeneration volume 7, Article number: 45 (2012) J Biol Chem. 2019 Jun 7;294(23):9213-9224 | |||
| 04 Feb 2021 | Adipokine Mini Review I Daniel J. Guerra, PhD. 03 Feb 2021 Authentic Biochemistry Podcast Publications. | 00:29:26 | |
*Adipose tissue is the endocrine organ that secretes “adipokines” *Nothing new to the Authentic Biochemistry crew; adipokines have been very well discussed here and their function as mediators of the feeding/appetitive/satiety response through the arcuate nucleus of the hypothalamus (POMCvNPY neurons) was most recently addressed. *Adipokines mediate the BMI, heart rate, serum glucose &fatty acid/TAG, and pro- inflammatory cytokine production;they are released by adipocytes (e.g. leptin and adiponectin) or preadipocytes, adipose tissue-infiltrated immune cells, or the gastric system Indeed, Th2 lymphocytes promote adipose glucose homeostasis by enhancing insulin sensitivity in adipocytes and browning/brown adipose tissue (BAT) activation but chronic inflammation of white adipose tissue (WAT) leads to the activation of pro-inflammatory pathways in adipocytes and resident immune cells following obesity involving the shutting down of Tregs and anti-inflammatory cytokines. Front Physiol. 2020; 11: 578966 Indian J Pharmacol. 2012 Mar-Apr; 44(2): 155–156. Cells. 2019 Mar; 8(3): 227. | |||
| 03 Apr 2024 | Biochemical Mosaic III.c.10 Atherogenesis and neointma formation are associated with sphingomyelinase membrane raft NOX aggregation during inflammasome activation.DJGPhD.2April24 | 00:29:47 | |
References J Lipid Res. 2022 Dec; 63(12): 100298. Mol Cells. 2020 Aug 31; 43(8): 749–762. Bach J.S. 1727. St Matthew Passion, BWV 244. https://www.youtube.com/live/3fP-rET0kFI?si=ZX-edMPg1wBA_5mh Squire, Chris. 1978. "You Can Be Saved" Yes. https://youtu.be/0TNzPHoVlz8?si=bFMp6w4T2SL6XxS4 | |||
| 24 Jul 2023 | ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23 | 00:29:56 | |
References Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234. Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195 | |||
| 01 Apr 2024 | Biochemical Mosaic III.c.8. S. aureus clearance via dual pyroptosis and necroptosis salientsand the control over the hyperinflammatory axis of clinical disease. DJGPhD.31.3.24 | 00:29:19 | |
References Cell Reports 2016.Volume 16, Issue 8, 23 Pages 2219-2230 Front Immunol. 2020; 11: 621733 Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969 | |||
| 16 Apr 2024 | Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.4. 15April 2024. Chemokine gradients and the membrane lipid raft. Authentic Biochemistry Podcast Dr. Daniel J. Guerra | 00:29:58 | |
References FEBS J. 2018 Aug; 285(16): 2944–2971. Nature Reviews Immunology 2023. volume 23, pages 236–250. Angiogenesis. 2021; 24(4): 719–753. Front. Immunol. 2022 Sec. Microbial Immunology Volume 12 Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service. https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D | |||
| 13 Nov 2024 | Authentic Biochemistry Podcast. Cell-Surface Enzymology: Blood Clotting and GPCR's Dr Daniel J. Guerra. 12Nov24 | 00:57:20 | |
References Biochemistry 1996 Feb 13;35(6):1904-10 Nature Communications 2023. volume 14,794 Canti per la Liturgia. Various Artists https://open.spotify.com/album/57EkvfRf0TDt5E7k92xZsa?si=616VsnS9SFCbnSUOKHpouA
| |||
| 25 Feb 2024 | A Dialectical Interlocution with Mozart. DJGPhD.24.2.24 Authentic Biochemistry Podcast | 00:28:52 | |
References Mozart.WA 1782. Fantasie in D minor. K.397 https://youtu.be/OYiz_u0tDwM?si=0dP736rTEkb4sauL 1785.Piano Concerto 22 in E flat Major.K.482 https://youtu.be/EJYPnrYNt8A?si=VqgS-PNw2bnbIFBj 1788.Divertimento in E♭ major, K. 563. https://youtu.be/2N4hHhTu4pw?si=p-VwHTTOK5ixFWfk 1787. Eine kleine Nachtmusik, K. 525. https://youtu.be/156u4nV2uGE?si=bRqysFpbi-6j0jMk | |||
| 05 Oct 2024 | Authentic biochemistry Sarcopenic Lipid and Oxidative Metabolism XII Dr Daniel J Guerra 04OCTOBER24 | 00:54:48 | |
References Nutrients 2021 . April 13:5 Bone 2022-11-01, Volume 164, Article 116539 Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383 Hunter-Garcia.1973 "Stella Blue" From [Wake of the Flood;lp] https://youtu.be/VKsWDyvWaL4?si=f6Fx7gWhXaed1ua3 | |||
| 11 Oct 2024 | Authentic Biochemistry Podcast. Sarcopenia XVI. Phosphatidic Acid and the mTORC axis of Muscle Protein Translation.DJGPhD10 October 24 | 00:55:51 | |
References Appl. Physiol. Nutr. Metab. 40: 1233–1241 (2015) BMC Biology 2011. 9:85 FEBS J. 2024. May. Volume291, 9.:1870-1885 Haydn, M. 1771. Requiem in C. Moll https://youtu.be/RpS3ZPynlvw?si=pEJueW9E-KTgA8H0 | |||
| 15 Apr 2024 | Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.3. 14 April 2024 .Authentic Biochemistry Podcast.Dr. Daniel J. Guerra | 00:29:57 | |
References Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366 Drugs. 2016 Jul;76(11):1067-79. Front Immunol. 2021; 12: 613591 J Appl Microbiol. 2009. Jun;106(6):1908-18 Exp Cell Res. 2015 May 1; 333(2): 195–200. Mediators Inflamm. 2017; 2017: 4806541. Parsons, G. McQuinn,R. 1971. Pale Blue [ Byrds] Byrdmaniax lp. https://youtu.be/Mh3J7GqrdzY?si=Kp0XfrwPtSi4vY6q Baker, G. 1967. "Blue Condition" [Cream]. Disraeli Gears lp. https://youtu.be/bjQjEyJwPpg?si=70Nye1AGPWsgG0hs Strauss, J.(II). 1866 "An der schönen blauen Donau", Op. 314 https://youtu.be/fHzhDKwYP2s?si=umxkaYC6nRvikezX | |||
| 25 Apr 2022 | Cytoepigenetics IIIB. The Geometrical constraints decribed by the valence shell electron pair repulsion in biochemical reactivity. DJGPhD.25.4.22 | 00:27:29 | |
Dr Guerra organic chemistry notes and concepts | |||
| 21 Mar 2023 | ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23 | 00:30:00 | |
References Methods Enzymol. 2009; 457: 425–450 Endocrinology, Volume 155, Issue 5, 1 May 2014, Pages 1653–1666 Am J Physiol Endocrinol Metab. 2008 Dec; 295(6): E1287–E1297 | |||
| 14 Oct 2023 | BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23 | 00:28:45 | |
Mol Cell Biol. 2012 Jan;32(1):126-38 Mutat Res. 2013 Jul-Sep;753(1):24-40 Molecular Neurobiology 2022. volume 59, pages 4223–4241 | |||
| 01 Mar 2023 | ImmunoEpigeneticsXXXVI. Tumor-specific methylation respondent transcription of Adenylate Cyclase 2 may be linked to differential cytokine expression controlling T cell activation. DJGPhD.01March23. | 00:29:57 | |
References Naunyn Schmiedebergs Arch Pharmacol . 2014 Apr;387(4):329-39. J Biol Chem. 2013 Mar 8; 288(10): 7137–7146 J Anim Sci. 1998 Jan;76(1):160-72 Journal of Bone Oncology 2017. Volume 9: 34-40 | |||
| 19 Nov 2023 | BioMedical PortraitVI.C.7 IEI/IEM pathobiochemistry involves bioenergetics, transcriptional , translational, and post-translational modification sequalae.DJGPhD.19.11.23 Authentic Biochemistry. | 00:30:00 | |
References Front Immunol. 2022; 13: 950536. Inflamm Res. 2018 Oct;67(10):813-828 Mol Biol Rep. 2023; 50(8): 6963–6974. Front Immunol. 2023; 14: 1151166 Dr Guerra: Graduate biochemistry lecture archive Schubert.F. 1827.December.Impromptu #3 in G flat major performed by Khatia Buniatishvili https://youtu.be/LUp2u9wI1fY?si=hhiUmiyXyQ78Qtaw and "Questions" Manfred Mann 1976. https://youtu.be/qvvstrKLvts?si=-I8bGmB2oC3FpPLw | |||
| 25 Mar 2023 | ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD | 00:30:00 | |
References Cell 2012 148DOI: (10.1016/j.cell.2012.01.031) Biotechnology Journal 2016. Volume11, Issue1 Special Issue: Biotech Methods and Advances: 71-79. Molecular Cancer. 2020. volume 19, Article number: 39. | |||
| 26 Feb 2024 | Biochemical Mosaic II. Plasmalogens & other ether lipids. c.1 DJGPhD.26.2.24. Authentic Biochemistry Podcast | 00:29:36 | |
References Cell Metab. 2014 Mar 4; 19(3): 380–392. Protein Cell 2018. 9, 196–206. Membranes 2023, 13(9), 764. Debussy , C. (. 1890;1905) Clair de lune. https://youtu.be/6zzWnxuQPWI?si=gcEAKpbgc9xO8esf Morricone. E. 1968. "Once Upon a Time in the West" https://youtu.be/j5eQ9UTmDLo?si=-eUjJ1s9hAd6fpwz Schubert, F. 1825. Ave Maria https://youtu.be/2H5rusicEnc?si=LcYisCODwtGgjjVx | |||
| 10 Aug 2024 | Authentic Biochemistry Podcast. Sphingolipids and Alzheimer’s Disease c.4 [09AUGUST24] Dr Daniel J. Guerra | 00:54:37 | |
References Front. Cell Dev. Biol.2019. 15 August Nat Rev Methods Primers. 2021. 1:30. Chemical Reviews. 2021.Vol 121/Issue 12 RSC Adv., 2024, 14, 7383-7413 Lennon/McCartney. 1970 "Let it Be https://youtu.be/QDYfEBY9NM4?si=b6-yGPS63sh8fEtC Lamm, R.1972. "While the City Sleeps" [Chicago V.lp] https://youtu.be/qCrgrGsBlr0?si=OSzuavyf40aEDn-r Mozart WA . 1791.Requiem in D minor K.626 https://youtu.be/YaH3zI0bYkM?si=o6vConcxFJYVXrqP | |||
| 16 Apr 2022 | Diabetes XXXIII. Synthesis of lecture arc Part 2. Dr Daniel J. Guerra. Authentic Biochemistry Podcast Studios. 16.4.22 | 00:29:58 | |
References Dr. Guerra's notes | |||
| 29 Oct 2022 | Membrane Biochemistry 71. Intracellular-endomembranous cholesterol trafficking and estrogen biosynthesis is under epigenetic control. DJGPhD.29.10.22.Authentic Biochemistry. | 00:29:55 | |
References Dr Guerra's lipid lectures Periodicum Biologorum 2011. 113(1):43-49 Obstet Gynecol Sci 2014. v.57(2) | |||
| 28 Mar 2024 | Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies | 00:30:00 | |
References Int J Mol Sci. 2021 Jul; 22(14): 7580. Trends Biochem Sci. 2023 Apr;48(4):331-344 Immunology. 2020;159:142–155 Curr. Opin. Immunol. 2020;62:39–44. Nat. Rev. Mol. Cell Biol. 2019;20:569–570. Lennon-McCartney. 1963. "This Boy" https://youtu.be/lW5D7HpYhBU?si=mHyiFng3rd3pukob Lennon-McCartney.1966. "And your Bird Can Sing" https://youtu.be/sOUlbredoUM?si=nPB64c8GS4joYx9G Lennon-McCartney 1969. "Let it Be" https://youtu.be/QDYfEBY9NM4?si=H6t6bwrv3vUNWoDj Vivaldi, A. 1715 "Gloria" https://youtu.be/RMHguvZPcqQ?si=igPXLKL9O0YbRWKz | |||
| 05 Apr 2023 | ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast. | 00:30:00 | |
References Curr Opin Biotechnol. 2020 Jun; 63: 111–117 Epigenomics. 2019. VOL. 11, NO. 68 May Front.Genet., 23 October 2018 Sec. Epigenomics and Epigenetics Volume 9. | |||