The Synthesis of Wellness (Chloe Porter)
Explore every episode of The Synthesis of Wellness
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| 17 Jul 2023 | 19. The 7 Types of Rest & How to Biohack Your Rest - with a Doctor of Psychology | 00:39:31 | |
In this episode, I am joined by an expert in the field of psychology to explore the seven different types of rest. This is the perfect episode for re-grounding yourself and finding rest and alignment in the everyday. Thanks for tuning it! Topics: - What are the 7 different types of rest? - Why do we need all 7? -What are easy ways to implement each type? -How can we optimize each type of rest using biohacks? -Thank you! Check out synthesisofwellness.com! Follow Chloe on Instagram: @synthesisofwellness Follow Chloe on TikTok: @chloe_c_porter Listen to The Synthesis of Wellness podcast available on Spotify, Amazon Music, and Google Podcasts! Visit linktr.ee/synthesisofwellness to get discount codes, schedule a BioPhotonic scanner consultation with Chloe, and so much more! We love when you leave a rating and review! And, if you loved this episode, in particular, screenshot it and post it to your Instagram story, so we can personally thank you for listening! | |||
| 13 Nov 2023 | 67. Teemu Arina - World Renowned Biohacker Speaks on His Life Optimization Strategies + The Importance of Letting Go of Dogma and Embracing the Dynamic Joys of Life | 00:56:10 | |
We are VERY honored to have Teemu Arina on the podcast today! With a remarkable two-decade career as a technology entrepreneur, author, and professional speaker, Mr. Arina stands at the forefront of digital transformation across various domains, including learning, work, leadership, health, and the future of humanity. His work revolves around optimizing productivity, health, and well-being by exploring the synergy between biological and technological tools. A renowned keynote speaker, he has graced stages worldwide and earned the title of Speaker of the Year in 2017. Topics: 1. Teemu's Health Journey - Personal story: Battling Ulcers and Stress - Teemu's Diet for Improved Health
2. Dietary Considerations and Diversity - The Importance of Diverse Dietary Choices to Avoid Food Sensitivities - Strategies for Maintaining a Balanced and Health-Conscious Diet
3. Exploring Testing - Overview of Nutritional Testing, Gut Testing, and Gene Testing - How These Tests Contribute to Health Optimization - How Often Should One Get Tested?
4. Daily Routines - Teemu's Morning and Evening Routines - Identifying Non-Negotiable Practices for Consistency - The Importance of Not Being Too Dynamic
5. Biohacking and Personal Growth - The Influence of Biohacking on Personal Growth and Identity - Transformative Philosophies and Principles Embraced During His Journey
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 04 Aug 2023 | 24. Using the Power of Epigenetics to “Hack Your Genes” & Overcome Self-Limiting Beliefs Plus Practical Strategies for Safeguarding Your Gene Expression | 00:37:28 | |
Welcome to another episode of The Synthesis of Wellness Podcast! This in a super in-depth episode dedicated to understanding how genetics work, how epigenetics work, and how you can essentially "hack" the way your genes are expressed in order to optimize you biological state. Topics: 1. Introduction - Defining epigenetics and its role in gene expression - Overcoming limiting beliefs about genetic predispositions 2. DNA Structure and Organization - Nucleotides: The building blocks of DNA - Double helix structure and base pairing - Chromosomes and genes: Organizing genetic information 3. Epigenetic Regulation: DNA Methylation - DNA methylation and its impact on gene expression - Enzymes involved in DNA methylation (DNMTs) - Factors affecting DNA methylation, including toxins 4. Epigenetic Regulation: Histone Modifications - Histone acetylation and deacetylation - Other histone modifications and their role in gene expression 5. Epigenetic Regulation: Non-coding RNAs - Non-coding RNAs (ncRNAs) and their regulatory functions - MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) - Influence of ncRNAs on gene transcription and expression 6. Strategies for Optimizing Epigenetic Expression - Dietary considerations for DNA methylation support - Impact of polyphenols and SCFAs on histone acetylation - Sleep optimization and its effect on gene expression 7. Environmental Factors and Epigenetics - Avoiding toxins and their influence on epigenetic regulation - Role of infections in epigenetic modifications - Air pollution, PCBs, phthalates, and their impact on gene expression 8. Mindfulness and Stress Reduction - Mindfulness practices to mitigate epigenetic dysregulation - Reducing stress and its effects on gene expression
Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness, or use the link: https://www.instagram.com/synthesisofwellness/ Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 26 Apr 2024 | 116. So You've Got Lyme/Mold, Now What? Herxheimer reactions, Why the Body is Chronically Inflamed, & Key Initial Strategies (Herbs, Binders, Tactics) | 00:29:27 | |
Today I am addressing the "early steps" in combatting Lyme or mold. So, I begin by diving into the phenomenon of Herxheimer reactions, elucidating its occurrence following antimicrobial therapy initiation for Lyme disease. Through this, I explore the intricate interplay between microbial factors, such as the release of endotoxins (LPS), and host immune responses, leading to a cascade of inflammatory reactions. Moreover, I provide practical strategies that may help mitigate Herxheimer reactions, including gradual dose titration, anti-inflammatory supplementation, binders, baths, and support for the body's natural detoxification pathways (liver, lymph, kidneys, and more). Topics: 1. Understanding Herx Reactions - Definition and Manifestation - General Overview of Symptoms 2. Underlying Mechanisms of Herx Reactions - Host Immune Responses - Microbial Factors 3. Microbial Factors in Herx Reactions - Release of Endotoxins - Role of Gram-Negative Bacteria - Impact on Immune Response (LPS) - Example: Lyme Disease as a Model 4. Inflammatory Response - Pro-inflammatory Cytokines - TNF-α, IL-6, IL-1β - Immune Response Propagation - Vasodilation - Vascular Permeability - Immune Cell Recruitment 5. Acute-Phase Response - Ex: Induction of Fever via the Hypothalamus - Systemic Manifestations and Other Symptoms 6. Phagocytic Immune Cells - Macrophages - Antigen Presentation - Cytokine Release - Neutrophils - Role in Early Innate Immune Response 7. Transition to Adaptive Immune Response - Specificity - Role of T Cells and B Cells - Immunological Memory 8. Implications of Inefficient Adaptive Immune Response Activation - Chronic Infection and Inflammation - Cause: Disruption in Antigen Presentation 9. Biotoxin Illness and Genetic Factors - Role of HLA Genes - Chronic Inflammatory Response Syndrome 10. Mitigating Herx Reactions - Slow Titration of Antimicrobial Therapy - Reducing Inflammation: Omega-3s, SPMs, Curcumin, Quercetin, Ginger, Boswellia, etc. - Supporting Clearance Pathways - Liver, Lymph, Kidneys - Hydration and Proper Elimination - Epsom Salt Baths - Use of Binders: Activated Charcoal, Chlorella, Cholestyramine etc.
Thank you to our episode sponsor: Check out The Honest Tooth Here! Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 21 Aug 2023 | 31. How to Harness the Power of Your Sirtuins to Increase Lifespan & Combat Cellular Dysfunction Associated with Aging - 7 Key Strategies | 00:31:52 | |
In this episode, we're delving into the fascinating world of sirtuins, exploring their role in countering the 9 hallmarks of cellular aging, and uncovering ways to optimize their activity for our benefit. We'll be exploring 7 proven strategies, backed by scientific research, that can effectively boost the expression of these longevity-promoting sirtuins within the body. Topics: 1. Introduction - Overview of NAD+ and its role in energy metabolism - Previous discussion on strategies to increase NAD+ levels - Importance of NAD+ in other reactions such as those mediated by sirtuins 2. Sirtuins: Introduction and Background - Definition and origin of the term "sirtuins" - Discovery of sirtuins and their role in yeast aging - Transition from yeast cells to mammalian cells - Introduction to SIRT1 as a focus for exploration 3. SIRT1: NAD+-Dependent Histone Deacetylase - Role of SIRT1 as an NAD+-dependent histone deacetylase - Gene silencing / gene expression - SIRT1's influence on "genome stability" mediated by its ability to silence genes 4. SIRT1's Multi-Faceted Activities - Beyond histone deacetylation: SIRT1's reach to non-histone proteins - Deacetylation of p53 and suppression of cellular senescence - Enhancement of telomere integrity - Connecting these activities back to those 9 hallmarks of aging 5. The Sirtuin Enhancement Toolkit for Longevity: 7 Strategies - Resveratrol and Pterostilbene - Increasing NAD+ availability through various methods - Exercise's influence on SIRT1 expression - DHA (Omega-3 fatty acid) and its role in activating SIRT1 - Zinc's importance for SIRT1's structural integrity and function - Nutraceuticals: Berberine, quercetin, fisetin, and curcumin - Intermittent fasting and its impact on NAD+ levels and SIRT1 Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 26 Jun 2024 | 126. Broad-Spectrum Micronutrient Supplements to Support Mental Health (Not Your Typical Multi-Vitamin) with Cory Rasmussen and Dallin Hardy, Research Scientist at Hardy Nutritionals | 01:02:04 | |
We are honored to have Cory Rasmussen and Dallin Hardy from Hardy Nutritionals on the podcast. Cory oversees the company's financial activities, including strategy, accounting, and reporting. Dallin, a research scientist, focuses on nutraceutical product development, consulting health professionals on micronutrients, and collaborating on research in integrative psychiatry. We'll explore how broad-spectrum micronutrient supplements can support mental health while also diving into some amazing mental-health-focused research studies utilizing "Daily Essential Nutrients." Topics: 1. Motivation for and Development of Hardy Nutritionals 2. Role of Micronutrients in Mental Health - Effects of nutrient deficiencies on the body's systems - Importance of micronutrients in supporting mental health - Micronutrients crossing the blood-brain barrier 3. Superior Mineral Forms and Chelation - Identification of superior mineral forms - Mimicking nature's complexity through the use of chelation 4. Research Studies on Micronutrients - Impact of micronutrients on pregnancy and antenatal depression 5. Gut Microbiome and Mental Health - Influence of the gut microbiome on mental health - Correlation of specific microflora imbalances with mental health conditions (e.g., ADHD, depression, Bipolar, OCD) - Effects of the gut microbiome on micronutrient absorption - Importance of greens, probiotics, and supplements like olive leaf extract 6. Products and Getting Started - Approaches for managing general daily stressors and anxieties - Overview of Daily Essential Nutrients and added vitamers - Explanation of vitamers Check out Hardy Nutritionals here Check out "Daily Essential Nutrients" here
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!
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| 07 Aug 2023 | 25. Ultimate Guide to Small Intestinal Overgrowth - Hydrogen & Hydrogen Sulfide Dominant SIBO, SIFO, & Intestinal Methanogen Overgrowth or IMO | 00:38:22 | |
Welcome to another episode of The Synthesis of Wellness Podcast! This episode covers almost everything you would want to know about different microbial overgrowths that can occur within the small intestines. Topics: 1. Introduction - Overview of different diagnoses related to gut dysbiosis - Types of intestinal microbial overgrowth: hydrogen dominant SIBO, hydrogen sulfide SIBO, IMO (intestinal methanogen overgrowth), SIFO (Small Intestinal Fungal Overgrowth), LIBO (Large Intestinal Bacterial Overgrowth) - Importance of the small intestine in nutrient absorption - Protective mechanisms against overgrowth: gastric acid secretion and intestinal motility 2. Prevalence and Risk Factors - Prevalence of SIBO among individuals with Irritable bowel syndrome, intestinal motility disorders, and chronic pancreatitis - Factors increasing SIBO prevalence: age, lower levels of stomach acid, slower gut motility - Female predominance in SIBO cases - Prevalence of undiagnosed SIBO and SIFO in the population 3. Symptoms and Malabsorption Issues - Common signs of small intestinal overgrowth: bloating, excessive gas, diarrhea, constipation, abdominal pain, and cramping - Nutrient malabsorption: fat-soluble vitamins (A, D, E, K), essential minerals (iron, calcium, magnesium), and B vitamins (B12, B1, B3) 4. Testing - Introduction to breath tests and stool tests - Trio Smart Breath Test for small intestinal overgrowth, assessing hydrogen, methane, and hydrogen sulfide levels - Unique testing options for SIFO using aspiration of small bowel fluids and urinary organic acids 5. Treatment Strategies for SIBO - Diet: Low FODMAP Diet and its impact on bacteria - Antimicrobial therapy using natural agents: Oregano oil, berberine, garlic, grapefruit seed extract - Probiotics for balancing gut bacteria - Prokinetics to improve gut motility 6. Treatment Strategies for IMO - Similarities with SIBO treatments - Elemental diet as a potential treatment - Reintroduction and Prevention Protocol - Use of intermittent fasting to stimulate the migrating motor complex 7. Treatment Strategies for SIFO - Addressing slow gut motility with prokinetics - Use of antifungals like fluconazole or herbal antifungals: artemisinin, oregano, garlic, olive leaf extract - Probiotic S. boulardii for reducing fungal colonization 8. Conclusion - Recap of the different small intestinal overgrowths: SIBO, IMO, & SIFO - Importance of identifying the specific type(s) for effective treatment - Understanding the symptoms, risk factors, and testing options for a personalized approach to wellness.
Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness, or use the link: https://www.instagram.com/synthesisofwellness/ Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 25 Aug 2023 | 33. MOTS-c (Peptides Episode) - The New Way to Support Insulin Sensitivity, Increasing MOTS-c Naturally, & How MOTS-c Could Enhance Your Workout + Combat Post-Menopausal Weight Gain | 00:34:47 | |
Today's episode is filled with peptide therapy, informational gems surrounding MOTS-c! We explore how MOTs-c triggers AMPK pathway activation, enhancing fatty acid oxidation and glycolysis, leading to increased ATP production and reduced "fat storage." Additionally, the episode highlights MOTs-c's role in addressing insulin resistance, evident from studies demonstrating lowered glucose and insulin levels in high-fat diet-induced obese mice and reduced menopausal weight gain. Moreover, the peptide's impact on mitochondrial biogenesis and skin health was discussed, emphasizing its potential to combat aging-related issues. Thanks for tuning in! Topics: 1. Introduction: - Overview of mitochondria's role in energy metabolism - Explanation of energy metabolism process - Importance of mitochondria in energy metabolism and aging 2. MOTs-c: Mitochondrial-Derived Peptide: - Role of mitochondria's genetic material and protein encoding - Introduction to MOTs-c and its translocation - Age-dependent expression and presence of MOTs-c 3. AMPK Pathway Activation by MOTs-c: - Explanation of AMPK as an energy sensor - AMPK activation mechanism by MOTs-c - Resulting increase in fatty acid oxidation and glycolysis - AMPK's role in inactivating ACC in order to prevent fatty acid storage (more fat "burning," less fat "storage") 4. MOTs-c's Impact on Insulin Resistance: - Study on high-fat diet-induced obese mice injected with MOTs-c - Lowered glucose and insulin levels in MOTs-c-treated mice - Reduced oxidative stress and enhanced cellular stress resistance - Study on normal and pre-diabetic patients showing lower MOTs-c levels in T2D 5. Mitochondrial Biogenesis and PGC1-alpha Activation: - Explanation of mitochondrial biogenesis - Role of PGC1-alpha in mitochondrial health and biogenesis - AMPK activation by MOTs-c leading to PGC1-alpha transcription - Stimulation of generation of new, healthy mitochondria 6. MOTs-c's Impact on Aging and Skin Health: - MOTs-c's influence on increasing NAD+ levels through AMPK activation - Necessity of NAD+ for longevity-enhancing sirtuins - MOTs-c's potential to combat age-related decline in NAD+ - Study indicating MOTs-c's potential in preventing skin aging 7. MOTs-c and Menopause: - MOTs-c's potential in reducing weight gain and insulin resistance in menopause - MOTs-c's effects on enhancing insulin sensitivity 8. Peptide Therapy Using MOTs-c: - Explanation of peptide therapy and MOTs-c administration - Caution and recommendation to work with licensed peptide physicians 9. Boosting Endogenous MOTs-c Production: - Human studies showing MOTs-c increases through exercise - Combination of exercise and peptide therapy for enhanced MOTs-c synergy - Personal experience with mitochondrial-focused therapies: an example stack
Thanks for tuning in! Use code CHLOEP for 5% off all Timeline Nutrition products If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 07 Feb 2025 | 164. Intestinal Dysbiosis and The Roles of Gastrointestinal Mucus and Secretory Immunoglobulin A | High and Low Levels of SIgA, and More | 00:17:03 | |
In this episode, we discuss the relationship between the intestinal mucus layer and secretory immunoglobulin A (sIgA), highlighting both as key components of the gut's first line of defense against pathogens, toxins, and environmental stressors. We detail how dysbiosis and microbial overgrowths can impact sIgA levels and can disrupt mucus integrity and function, contributing to increased intestinal permeability and inflammation. We then examine several additional factors influencing sIgA production. Topics: 1. Introduction: Importance of Secretory IgA and Intestinal Mucus - Intestinal epithelial lining and its protective mucus layer - Focus on intestinal dysbiosis and sIgA
2. Anatomy of the Gastrointestinal Lining - Intestinal lumen, microbiome, mucus layer, epithelial cells, tight junctions, lamina propria, and smooth muscle - Role of goblet cells in mucus secretion and epithelial integrity
3. Role of the Protective Mucus Layer - Dual function of the mucus layer as a physical and biochemical barrier - Composition of mucus: mucins, antimicrobial peptides, immunoglobulins
4. Goblet Cells and Mucin Production - Mechanisms of mucin secretion and hydration - Variability in goblet cell density across the intestinal tract - Dysfunctions linked to conditions like IBD and IBS
5. Microbial Interactions with Mucins - Glycan structures in mucins - Roles of commensal and pathogenic bacteria in mucin degradation and mucus turnover - Importance of regulated mucus production for gut homeostasis
6. Dysbiosis and Mucus Degradation - Excessive mucin degradation leading to thinning of the mucus layer - Consequences of increased intestinal permeability and inflammation - Role of dysbiosis in disrupting the mucus layer
7. Overview of Secretory IgA - Introduction to secretory IgA (sIgA) and its role in mucosal immunity - Mechanisms of immune exclusion and pathogen neutralization
8. Production and Function of Secretory IgA - sIgA production by plasma cells in the lamina propria - Translocation of IgA through epithelial cells into the gut lumen - sIgA binding to mucins and its immunological role in the mucus layer
9. Factors Affecting Secretory IgA Levels - Possible contributing factors to low sIgA levels - Implications of low and high sIgA levels for immune defense and intestinal health
10. Interactions Between Secretory IgA and Dysbiosis - Cyclical relationship between low sIgA, dysbiosis, and infections - Examples of overgrowths, like candida, disrupting sIgA - Importance of addressing immune dysregulation to break the cycle
11. Bioindividual Root Cause Approach - Factors to consider Thank you to our episode sponsors: 1. Shop Fresh Press Farms' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. 2. Check out Spectrum Sciences' Serums and The Vitamin B12 Protocol here, and use code CHLOE15 for 15% off. Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness | |||
| 01 Nov 2024 | 149. The Gut Microbiome & Serotonin Synthesis | Impacts of Intestinal Dysbiosis on Serotonin Production, Impacts of Low Serotonin on Gut Motility, & More | 00:18:23 | |
In this episode, we explore serotonin synthesis within enterochromaffin (EC) cells in the gut, detailing how tryptophan is converted into serotonin through enzymatic processes. We examine the role of gut microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), in modulating the synthesis of serotonin including impacting tryptophan hydroxylase activity. We explore serotonin's interactions with receptors on enteric neurons and vagal afferent fibers, analyzing how these signaling pathways influence gut motility. Finally, we uncover conditions and symptoms associated with low serotonin production and the importance of the intestinal microbiome. Topics: 1. Introduction to Gut-Produced Serotonin - Serotonin production within the gut. - Serotonin’s role beyond mood. - Synthesis, causes of low serotonin, related GI symptoms. 2. Gut Lining Structure and Cell Types - Layers of the gut lining, focusing on the mucosa. - Description of epithelial cells, including enterocytes, goblet cells, Paneth cells, and enteroendocrine cells. - Role of enterochromaffin (EC) cells in serotonin production. 3. Serotonin Synthesis in EC Cells - Location and function of EC cells. - How EC cells synthesize serotonin from tryptophan. 4. Biochemical Pathway of Serotonin Production - Step-by-step process: conversion of tryptophan to serotonin. - Enzymes involved, including TPH1 and AADC. - Importance of tryptophan availability in serotonin synthesis. 5. Storage and Release of Serotonin in EC Cells - Role of VMAT1 in serotonin storage within vesicles. - Controlled release. 6. Triggers for Serotonin Release - Physical triggers: mechanical stretch, pressure from food intake. - Chemical triggers: microbial metabolites, bile acids. - Receptors involved (GPCRs, TGR5) and signaling pathways. 7. Release of Serotonin into Intestinal Lining Layers - Serotonin exocytosis and interaction with nearby cells. - Release of serotonin on both luminal and basolateral sides of EC cells. - How luminal and basolateral release affects gut motility and barrier function. 8. Serotonin’s Role in Gut Motility - Interaction with 5-HT3 and 5-HT4 receptors on enterocytes and enteric neurons. - Activation of the enteric nervous system (ENS) in the submucosal and myenteric plexuses. - Coordination with pacemaker cells for peristaltic movement. 9. Immune Function and Serotonin in the Gut - Effect on immune cells. 10. Gut-Brain Communication via Serotonin and the Vagus Nerve - Activation of vagal afferent fibers by serotonin. 11. Contributing Factors to Low Serotonin Production - Impact of dysbiosis and reduced SCFA production. - SIBO specifically. - Intestinal inflammation in general. - Imbalanced microbiota and inflammation can disrupt EC cell function. 12. Manifestations of Low Serotonin in the Gut - Effects on motility: constipation, dysmotility... - Common GI symptoms, including bloating, discomfort, and fullness. - Association with conditions like IBS. 13. Supporting Serotonin Production in the Gut - Painting a full picture and identifying root causes. - Strategies to foster a healthy gut microbiome. - Role of sunlight and tryptophan-rich foods in serotonin production. - Stool testing for microbiome imbalances.
Thanks for tuning in! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter | |||
| 20 Dec 2024 | 156. The Oral Microbiome in Modulating Intestinal Health, the Intestinal Microbiome, and Brain Health | Examining The Oral-Gut-Brain Axis, Effects of Oral Dysbiosis, Neuroinflammation, & More | 00:18:57 | |
In this episode, we go through the interplay between the oral microbiome, the intestinal microbiome, and brain health, focusing on the mechanisms through which dysbiosis in these ecosystems influences neuroinflammation and central nervous system function. We explore the molecular pathways by which bacterial metabolites and inflammatory mediators from the oral and intestinal microbiota can disrupt the blood-brain barrier, activate glial cells, and impair neuronal processes. We also go through symptoms associated with microbial imbalance as well as oral health practices. Topics:
Thank you to our episode sponsor: 1. Check out Ulyana Organics' Tallow Wild Yam Cream and Healing Facial Oil, and use code CHLOE10 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 22 Apr 2024 | 115. The Biochemistry of Oral Health, Tooth Powder, The Oral Microbiome, Toothpaste Ingredients to Look Out For, and More With Justin Bosley, President of Evexia Science | 01:03:42 | |
Today, we are delighted to introduce Justin Bosley, the President and Head Chemist at Evexia Science. Raised amidst health challenges that confounded traditional medical solutions, Justin embarked on a lifelong quest for remedies. Fueled by an innate curiosity and a passion for health and science, he pursued a degree in nutritional science at Brigham Young University. Subsequently, driven by an unyielding commitment to innovation, he augmented his expertise with another degree in chemistry, specializing in biochemistry. Justin's journey into product formulation initially stemmed from personal necessity—unable to find suitable solutions in the market, he took matters into his own hands. What began as a personal endeavor soon evolved into a shared passion as his creations garnered acclaim among friends and family. Encouraged by their positive reception and fueled by a burgeoning demand, Justin made the courageous decision to pivot from a conventional career path, dedicating himself fully to Evexia Science. Topics: 1. Justin's story and motivation for Evexia Health 2. What is plaque? - Formation and composition of plaque - Transformation into calculus or tartar - Microbial-rich environment 3. Negative consequences of plaque - Greater risk for diabetes - Potential link to dementia - Impact on brain health due to tooth infections and neuroinflammation 4. Effects of acids and bases on teeth - Baking soda's impact on plaque, gingivitis, and gum bleeding - Acid neutralization - Hidden sources of acids in one's diet - Acid-producing bacteria 5. Strategic Ingredient breakdown of The Honest Tooth - Baking soda - abrasive - Monolaurin - Essential oils - Xylitol 6. Common misconceptions about oral care 7. Tooth powder vs. paste 8. Electric toothbrush vs. regular The Honest Tooth - Evexia Health Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 13 Sep 2023 | 41. Dr. Alexa Chichak - Women's hormones, DUTCH testing, Menstrual Cycle Optimization, Seed Cycling, Cosmetic Procedures, Microneedling, PRP, & More! | 00:54:05 | |
We are so thrilled and honored to be joined by Dr. Chichak! Dr. Alexa Chichak, a graduate of Boucher Institute of Naturopathic Medicine with an undergraduate degree in Human Kinetics from the University of British Columbia, is passionate about addressing hormonal imbalances, mental health, digestive concerns, autoimmune conditions, and stress. With a holistic approach, she caters her treatments to individuals of all ages and health issues. Believing in the body's inherent healing capacity, she provides support and encouragement for the healing process. She is a wealth of knowledge, and I am so honored to welcome her to the podcast! Topics: 1. Women's Health & Hormones Introduction: - Brief overview of hormones and their crucial role in women's health. 2. Key Hormones for Women's Health: - Discussion of essential hormones to focus on during bloodwork: pituitary, thyroid, adrenal, and ovarian hormones. - Urine testing? DUTCH Test 3. Common Hormonal Imbalances in Women: - Exploring prevalent hormonal imbalances frequently experienced by women. 4. Contributing Factors to Hormonal Imbalances: - In-depth examination of underlying factors that often lead to hormonal imbalances. 5. Gut Health and Hormonal Imbalances: - Exploring the intricate relationship between gut health and the occurrence of hormonal imbalances in women. 6. Dietary Strategies for Hormonal Health: - Insights into dietary approaches that promote and maintain balanced hormonal health. 7. Macronutrients and Hormonal Well-being: - Explaining the roles of fats, proteins, fibers, and carbohydrates in influencing women's hormonal balance. 8. Tailoring Your Diet to Your Menstrual Cycle? - Seed cycling: How to seed cycle and why - Magnesium: Why is it helpful 9. Cosmetic Procedures: - Facial Acupuncture: Discussion of the benefits and mechanisms of facial acupuncture. - Microneedling: Exploring how microneedling works and what it does to the face (+ a brief conversation on collagen) - PRP for Hair Loss and (Facial) Volume Loss: Explanation of PRP therapy's role in addressing hair loss, boosting collagen production, and addressing volume loss within the face. Thanks so much for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 05 Jul 2024 | 128. Psychobiotics - How Microbial Metabolites Modulate Stress & Enhance Mood by Interacting with the Enteric Nervous System, Vagus Nerve, & Brain (Plus a Dive into Bifidobacterium Longum 1714) | 00:23:14 | |
This episode dives into the emerging concept of psychobiotics, exploring how these live (probiotic) microorganisms can positively impact mental health by interacting with the gut-brain axis. We'll provide an in-depth look at the anatomy of the gut lining and the enteric nervous system, explaining how these pathways facilitate communication between the gut and the brain. Additionally, we'll spotlight the psychobiotic Bifidobacterium longum 1714, detailing its mechanisms and benefits for stress and anxiety relief. Topics: 1. General Overview of Psychobiotics - Definition and origin of the term "psychobiotics". - Mental health benefits: alleviating anxiety, depression, enhancing cognitive function, and stress resilience. - Introduction to the gut-brain axis. 2. The Gut-Brain Axis - Detailed explanation of the gut-brain axis. - Overview of the divisions of the nervous system (CNS and PNS). - Further division of the PNS into somatic and autonomic nervous systems. - Division of the autonomic nervous system. - Detailed structure and function of the enteric nervous system (ENS). 3. Gut Lining Anatomy - Layers of the gut lining from the inside out: gut lumen, mucus layers, intestinal epithelium. - Structure and function of the intestinal epithelium and its renewal process. - The role of villi and microvilli in increasing the surface area for nutrient absorption. - Overview of the lamina propria and its immune components. - Overview of the muscularis mucosae 4. Submucosa and Enteric Nervous System (ENS) - Description of the submucosa and its components (blood vessels, lymphatics, nerves). - Detailed structure and function of the submucosal (Meissner's) plexus. - Beyond the submucosa: muscularis externa and the myenteric (Auerbach's) plexus. - Interaction between the ENS and the vagus nerve. 5. Psychobiotics in Action: Bifidobacterium longum 1714 - Introduction to Bifidobacterium longum 1714 and its mental health benefits. - Production of key metabolites (SCFAs, serotonin, GABA) and their roles. - Interaction of metabolites with the ENS and the vagus nerve. - Detailed pathway of signals from the gut to the brain. 6. Other Notable Psychobiotics - Quick overview of other psychobiotics studied for mood regulation: - Lactobacillus rhamnosus GG - Lactobacillus helveticus R0052 - Bifidobacterium breve M-16V - Lactobacillus casei Shirota - Bifidobacterium infantis 35624 - Lactobacillus plantarum PS128 Thank you to our episode sponsor: Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 13 Sep 2024 | 140. Gastrointestinal Mucus & Its Role in Combating Increased Intestinal Permeability | Highlighting Mucins & Secretory IgA, Along with Tools to Support Optimal Mucus Levels & Protect the Epithelium | 00:20:55 | |
In this episode, we explore the crucial role of the protective mucus layer in maintaining intestinal lining integrity, highlighting how it shields the epithelial cells from harmful substances and supports overall digestive function. We dive into the components and functions of mucins, goblet cells, and secretory IgA, explaining their contributions to gut immunity and barrier integrity. Additionally, we discuss strategies for supporting mucus production centered around butyrate, N-acetyl glucosamine, and plant-derived mucilage. Topics: 1. Introduction: Overview of the Gastrointestinal Mucus Layer - Importance of the mucus secretions in forming a protective layer - Brief review of the gastrointestinal lining and its structure 2. The Mucosal Layer and Its Components - The mucus layer on the epithelial cells of the mucosa - Four main layers of the intestinal wall, focusing on the mucosa - Epithelium: absorptive enterocytes and mucus-secreting goblet cells - Lamina propria: connective tissue rich in immune cells, blood vessels, and lymphatics - Smooth muscle aiding in subtle movements - Submucosa: thicker connective tissue layer with blood vessels, nerves, and lymphatics 3. Dual Function of the Mucus Layer - Physical barrier preventing pathogens and toxins from reaching epithelial cells - Biochemical barrier housing antimicrobial peptides and immunoglobulins 4. Goblet Cells and Their Role in Mucin Production - Goblet cells: specialized epithelial cells producing mucins - Distribution of goblet cells from small to large intestine - Importance of goblet cells in maintaining the mucus barrier 5. Mucins: Structure and Glycosylation - Glycosylation and its role in mucus properties and host-microbiota interactions - Commensal bacteria and their interactions with mucins (e.g., Bacteroides and Akkermansia muciniphila) 6. The Importance of Controlled Mucin Degradation - Mutualistic relationship between mucin-degrading bacteria and the host - Risks of dysregulated mucin degradation, leading to dysbiosis and leaky gut 7. Secretory IgA and Its Role in Gut Immunity - Overview of secretory IgA (sIgA) and its production - sIgA’s mechanism of neutralizing pathogens "without inflammation" - Immune exclusion as a defense mechanism to maintain gut barrier integrity 8. Recap: The Dynamic Nature of the Mucus Layer - Continuous renewal of the mucus layer and the role of goblet cells and plasma cells - Importance of regular mucus turnover for maintaining a healthy gut barrier 9. Supporting Gastrointestinal Mucus Production - Short-chain fatty acids (SCFAs) and their role in stimulating mucus production - Butyrate and its effects on goblet cells and epithelial repair - N-Acetyl Glucosamine (NAG) as a supplement to support mucin glycosylation 10. Supporting the Intestinal Lining After Dysbiosis or Increased Permeability - Mucilage and its role in coating and soothing mucosal surfaces - Plant-derived mucilage from slippery elm and marshmallow root - Physical protection provided by mucilage - Soothing effects on inflamed tissues and promoting smooth digestion Thank you to our episode sponsor: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 19 Jul 2024 | 131. Focusing on Neuroprotection & Reducing Neurotoxin Exposure - How Neurotoxins (Organophosphates, Mercury, Mycotoxins, & More) Disrupt Neuronal Communication & Can Impair Cognition | 00:22:30 | |
In this episode, we explore the intricacies of neuronal communication, delving into how neurons transmit signals through synaptic connections using neurotransmitters like glutamate and GABA. We also examine the effects of neurotoxins, such as heavy metals and environmental pollutants, on these critical synaptic pathways, leading to cognitive and neurological impairments. Lastly, we discuss neuroprotective strategies to mitigate neurotoxin exposure and promote optimal brain health. Topics: 1. Overview of Brain Cell Anatomy - Types of brain cells: neurons and glial cells. - Structure of neurons: - Soma (cell body): contains nucleus and organelles. - Dendrites: receive signals from other neurons. - Axon: transmits electrical impulses away from the soma. - Synaptic terminals: form synapses with target cells. 2. Neuronal Communication - Synapse structure: - Presynaptic terminal. - Synaptic cleft. - Postsynaptic membrane. - Neurotransmitters: - Role in neuronal communication. - Excitatory neurotransmitters (e.g., glutamate). - Inhibitory neurotransmitters (e.g., GABA). 3. Summary of Neuronal Communication - Recap of excitatory and inhibitory neurotransmitters. - Importance of maintaining proper neuronal communication. 4. Neurotoxins and Their Effects - Types of neurotoxins: - Heavy metals (e.g., lead, mercury, arsenic, cadmium, aluminum). - Chemical neurotoxins (e.g., organophosphates, solvents). - Biological toxins (e.g., mycotoxins). - Environmental pollutants (e.g., PCBs, dioxins). - Mechanisms of neurotoxin damage: - Disruption of neurotransmitter release. - Impairment of receptor function. - Interference with ion channel operation. 5. Example: Mercury's Impact on Cognitive Function - Pathway of mercury exposure and accumulation in the brain. - Disruption of calcium homeostasis and synaptic transmission. - Resulting cognitive impairments. 6. Strategies to Reduce Neurotoxin Exposure - Nutrition: - Opting for organic produce. - Washing produce properly. - Avoiding MSG and aspartame. - Limiting aluminum exposure (baking powder). - Evaluating cookware. - Avoiding farmed salmon. - Water and air quality: - Using water filtration to remove fluoride. - Choosing fluoride-free toothpaste. - Improving air quality and mold remediation. - Using air-purifying plants (e.g., aloe vera, English ivy). - Reducing exposure to places with highly-concentrated neurotoxic chemicals (e.g., nail salons).
Thank you to our episode sponsor: Use code CHLOE15 to get 15% off Tremetes' Turkey Tail Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 30 Oct 2023 | 61. James Barry - Why We Need to Consume Organ Meats in Addition to Skeletal Muscle, Common Misconceptions, Plus a Tasty & Convenient Way to Consume Organ Meats: Pluck Seasoning | 01:00:21 | |
We are so honored to have James Barry on the podcast today! James Barry began his culinary career as a private chef for celebrities including Tom Cruise, George Clooney, and Barbra Streisand, among others. He co-authored recipes in Margaret Floyd's "Eat Naked" and subsequently co-authored "The Naked Foods Cookbook". Recently, James introduced "Pluck", a pioneering organ-based seasoning, offering a tasty and convenient method for people to incorporate organ meats into their meals. I not only LOVED this conversation, but I really admire his story as well! He is incredible! Topics: 1. Origins of Pluck Seasoning - Inspiration behind Pluck - How the idea originated 2. Historical Consumption of Organ Meats - Role in traditional diets - Decline in modern Western diets 3. Culinary Aspects of Organ Meats - Flavors and experiences added to dishes 4. Nutritional Profile - Distinction of organ meats from other animal parts 5. Myths and Misconceptions - Debunking common myths - Addressing concerns about toxins 6. Health and Nutritional Benefits - Key reasons to incorporate organ meats into diets 7. Understanding Pluck Seasoning - Definition and ingredients - Organ meats used in the seasoning - Preparation process and safety measures 8. Incorporating Pluck in Everyday Cooking - Usage recommendations for those new to organ meats
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 25 Oct 2024 | 148. 1,25-Dihydroxycholecalciferol & The Brain | Forms of Vitamin D, Activation to 1,25-Dihydroxycholecalciferol, Mechanisms of Action / Neuroprotective Effects of Vitamin D, Cognitive Symptoms | 00:19:27 | |
In this episode, we explore the role of Vitamin D in brain health, focusing on how its active form, calcitriol (1,25-dihydroxyvitamin D3), influences cognitive function and neuroprotection. We’ll discuss the synthesis of Vitamin D, its conversion into its active form, and its ability to cross the blood-brain barrier to exert effects on neurons and glial cells. Additionally, we will highlight how calcitriol regulates gene expression through Vitamin D Response Elements (VDREs), impacting inflammation, antioxidant defense, and neurotrophic support. Finally, we touch on the symptoms of low Vitamin D and the link to cognitive decline. Topics: 1. Introduction to Vitamin D and the Brain - Forms of Vitamin D, synthesis, conversion/activation, and its role in the brain 2. Vitamin D - Vitamin D2 (ergocalciferol), plant-based sources like mushrooms - Vitamin D3 (cholecalciferol), UVB radiation, animal-based foods - Inactive forms 3. Synthesis and Conversion of Vitamin D3 - Synthesis in the skin: 7-dehydrocholesterol converts to pre-vitamin D3 - Conversion in the liver: 25-hydroxylase converts D3 to 25-hydroxyvitamin D (calcidiol) - Final activation in the kidneys: 1-alpha-hydroxylase converts calcidiol to 1,25-dihydroxycholecalciferol (calcitriol), the active form 4. Calcitriol and the Blood-Brain Barrier - Calcitriol’s lipophilic nature, crossing the BBB - The structure and function of the blood-brain barrier - How calcitriol diffuses across the BBB and reaches brain cells 5. Calcitriol's Role in the Brain - Interaction with Vitamin D receptors (VDRs) in neurons and glial cells - VDRs in key brain regions: hippocampus, prefrontal cortex, cerebellum, basal ganglia - Binding of calcitriol to VDRs, conformational change, and formation of the VDR-RXR complex 6. Gene Regulation via Vitamin D Response Elements (VDREs) - Overview of VDREs in promoter regions of genes - Role of calcitriol in activating or repressing gene transcription 7. Impact on Inflammatory Responses - VDREs in anti-inflammatory genes promote IL-10 expression - Calcitriol’s role in reducing pro-inflammatory cytokines like IL-6 and TNF-alpha 8. Neurotrophic Factors - VDREs’ role in regulating genes that promote BDNF - BDNF’s impact on neuron survival, growth, and synaptic connectivity 9. Antioxidant Enzymes - VDREs influence the expression of glutathione peroxidase and superoxide dismutase (SOD) - The role of these enzymes in defending neurons from oxidative stress 10. Brain Regions & Calcitriol - Hippocampus: Learning, memory, neurogenesis, synaptic plasticity - Prefrontal Cortex: Executive functions, mood regulation - Cerebellum: Motor control, cognitive processing, calcium homeostasis - Basal Ganglia: Movement regulation, protection of dopaminergic neurons - Amygdala: Emotion processing, fear, anxiety, stress response 11. Interconnection of Brain Regions - How Vitamin D’s effects on neurotransmitter regulation, anti-inflammatory action, and calcium homeostasis create a global protective effect. 12. Conclusion - Recap of calcitriol’s cellular mechanisms and neuroprotective effects - Symptoms of low Vitamin D Thank you to our episode sponsor: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 15 Nov 2024 | 151. The Gut-Immune Axis & the Beneficial Role of Immunoglobulins in Supporting Intestinal Barrier Function | IgG, Secretory IgA, and More | 00:16:45 | |
In today’s episode, we dive into the interplay between the gut and immune system, focusing specifically on the critical role of immunoglobulins in mucosal immunity. Immunoglobulins, specialized glycoproteins synthesized by B cells, serve as the frontline defenders within the gastrointestinal tract, where they neutralize pathogens and maintain immune homeostasis. We also explore the mechanisms by which these antibodies fortify the intestinal barrier and aid in preventing dysbiosis. We finish by going through tools for supporting immunoglobulins. Topics: 1. Introduction - Overview of the gut-immune axis and focus on immunoglobulins. - How low levels of immunoglobulins can contribute to dysbiosis. 2. What Are Immunoglobulins? - Immunoglobulins (Igs) are glycoproteins produced by B cells. - They play a critical role in recognizing and neutralizing pathogens. - Antigen-binding sites for specific targeting. - Essential for immune homeostasis and pathogen elimination. 3. Immunoglobulins’ Role in the Gut - Protect mucosal surfaces exposed to antigens. - B cells differentiate into plasma cells, and secrete immunoglobulins into the gut lumen. 4. Layers of the Intestinal Lining - Intestinal lumen is covered by a protective mucus layer. - Mucosa consists of epithelial cells, including mucus-secreting goblet cells. - Lamina propria beneath the epithelium is rich in immune cells. - Submucosa beneath mucosa. 5. The Function of the Mucus Layer - Acts as a physical barrier against pathogens. - Functions as a biochemical barrier by housing antimicrobial peptides and immunoglobulins. - Primarily composed of mucins secreted by goblet cells. - Goblet cells release mucins in response to stimuli, forming gel-like mucus. 6. Introduction to Secretory Immunoglobulin A (sIgA) - sIgA is the most abundant immunoglobulin in mucosal secretions. - Forms a protective barrier in the mucus layer. - Plays a critical role in immune exclusion by trapping and neutralizing pathogens. - Helps maintain non-inflammatory defense at mucosal surfaces. 7. Production of Secretory IgA - Plasma cells in the lamina propria secrete IgA. - IgA binds to receptors on epithelial cells and is transported across to the gut lumen. - sIgA to neutralize pathogens effectively within the mucus layer. 8. Functions of Secretory IgA in the Gut - Binds to antigens like bacterial walls, viruses, and toxins. - Traps antigens in the mucus to prevent adherence to epithelial cells. - Provides immune exclusion, reducing pathogen access to the gut lining. - Maintains mucosal barrier integrity to prevent inflammation. 9. Impact of Low sIgA Levels - Contributes to dysbiosis by allowing pathogenic bacteria to proliferate. - Intestinal hyperpermeability. - Increased risk of intestinal inflammation and infections. 10. Comparison with Other Immunoglobulins: IgG and IgM - IgG is most abundant in blood. - IgM is produced early in immune responses. - IgM can also be secreted into the gut lumen in IgA deficiency. 11. Immunoglobulin Supplements - IgG supplements. - Colostrum: IgG to help neutralize pathogens. - Supports gut barrier integrity. 12. Supporting Immunoglobulin Levels - Colostrum - Probiotics, prebiotics - Vitamin A - Zinc 13. Conclusion - Immunoglobulins, intestinal health, and immune balance.
Thanks for tuning in! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter
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| 28 Aug 2023 | 34. Bioregulator Peptides (Peptides Episode) - Bring the Body Back into Balance & Combat Aging Using Pinealon, Epithalon, Cortagen, Pancragen, & Thymogen | 00:34:59 | |
In today's episode, we are diving deep into the world of bioregulator peptides, what makes them unique when compared to other peptides, and different peptide stacks for different uses. Thanks so much for tuning in! Topics: 1. Introduction - Biohacking Congress Meet-up in Miami 2. Overview of Bioregulator Peptides - Introduction to bioregulator peptides - Comparison with other peptide types (e.g., bpc-157) - Advantages of bioregulator peptides due to size and permeability - Tissue-specific effects of bioregulators 3. Gene Regulation and Cellular Differentiation - Explanation of gene regulation's permanent impact on cell differentiation - Importance of gene expression in cell differentiation but also in the functional activity of the cell 4. Mechanism of Bioregulator Peptides - Interaction of bioregulator peptides with DNA regions - Binding to histone proteins at the gene promoter site - Activation of gene expression and protein synthesis - Tissue-specificity of bioregulator peptides 5. Discovery and Terminology of Bioregulator Peptides - Vladimir Khavinson's role in peptide bioregulator discovery - Extraction of peptides from various tissues - Introduction of synthetic bioregulator peptides - Terminology: cytomedines and cytogen 6. Examples of Bioregulator Peptides - Thymagen: Immunomodulatory effects - Epithalon (Epitalon): Anti-aging effects and telomere elongation - Cortagen: Benefits for central nervous system and neuroprotection - Pancragen: Influence on pancreas / metabolic dysfunction and diabetes - Pinealon: Neuroprotection, melatonin regulation, circadian rhythm, memory, etc... 7. Potential Applications and Stacking of Bioregulator Peptides - Discussion on administration methods (injections, sublingual, oral) - Introduction to an anti-aging stack - Components of the stack: epitalon, pinealon, BPC-157, NAD+ - Personal preferences on peptide selection
Thanks for tuning in! Use code CHLOEP for 5% off all Timeline Nutrition products If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 03 Nov 2023 | 63. Antimicrobial Synergy Between LL-37 Peptide & CAPE (Bioactive Contained in Propolis) - One of My Antimicrobial Stacks | 00:32:34 | |
Today, I am diving into the antimicrobial synergy between a bioactive compound called CAPE (found in propolis) and the LL-37 antimicrobial peptide. We explore how and why these may act synergistically and further dive into my personal antimicrobial stacks. You don't want to miss this one!
Topics: 1. Introduction to Propolis - Definition of Propolis - How Bees Produce Propolis - Functions of Propolis in the Hive - Factors Influencing Propolis Composition 2. Key Bioactives in Propolis - Overview of Bioactive Compounds - Notable Compound: Caffeic Acid Phenethyl Ester (CAPE) 3. CAPE's Biological Activities - Modulating Inflammation - Inhibiting Arachidonic Acid (AA) Release From Cell Membrane - Impact on Prostaglandin and Leukotriene Production - Inhibition of LOX and COX Enzymes 4. CAPE's Anti-Biofilm and Antimicrobial Properties - Effectiveness Against Candida albicans - Inhibition of Biofilm Formation - Stimulation of Endogenous Antimicrobial Peptides - Focus on β-defensin 3 - Synergy with LL-37 Peptide 5. LL-37 Peptide - Introduction to Cathelicidins - Role of LL-37 - Mechanism of Action - Immunomodulatory Effects 6. Considerations and Precautions - Potential Herxheimer Reaction - Dosage for LL-37 - Dosage Estimate for CAPE in Propolis 7. Conclusion and Safety - Importance of Consulting a Licensed Physician - Wrapping Up the Discussion
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 23 Aug 2023 | 32. Dr. Barrie Tan - Vitamin E, Why You Need to Make Sure You're Taking Tocotrienols, & Why Tocopherols Might Be Detrimental | 00:54:26 | |
Today, we have the pleasure of welcoming Dr. Barrie Tan to the show. Dr. Tan's academic journey led him to earn his Ph.D. in Chemistry/Biochemistry from the University of Otago, and he also served as a professor at UMass. Dr. Tan's remarkable contributions have solidified his position as a trailblazer and the foremost expert in the realm of vitamin E. His relentless passion drives him to delve into the exploration and enhancement of phytonutrients that hold the promise of mitigating chronic ailments. Topics: 1. Distinguishing Tocopherols from Tocotrienols - Exploring chemical structures of tocopherols and tocotrienols - Understanding their respective roles as antioxidants 2. Dr. Tan's Annatto Plant Discovery - Unveiling Dr. Tan's breakthrough in the realm of tocotrienol research - Shedding light on the significance of the annatto plant 3. Early Tocotrienol Studies and Health Insights - Discussing initial research findings 4. Evaluating Potential Concerns with Tocopherols - Examining the possible detrimental effects of tocopherols - Considering drawbacks and contrasting with tocotrienol benefits 5. Tocotrienols' Impact on Cardiovascular Well-being - Analyzing the contribution of tocotrienols to cardiovascular health - Uncovering mechanisms driving positive cardiovascular effects 6. Tocotrienols and Inflammation Reduction - Elaborating on the connection between tocotrienols and inflammation - Identifying specific inflammation markers influenced by tocotrienols 7. Tocotrienols' Role in Metabolic Health - Investigating tocotrienols' role in metabolic syndrome and diabetes management - Examining how tocotrienols affect metabolic health 8. Recommended Usage and Dosage of Tocotrienols - Addressing potential variations in dosage based on health conditions 9. Exploring Geranylgeraniol: A Brief Conversation on What It Is and Its Health Benefits -- Timeline Nutrition Ad -- Thanks for tuning in! Use code CHLOEP for 5% off all Timeline Nutrition products Use code "Synthesis" to get a FREE copy of Dr. Tan's book, "The Truth About Vitamin E" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 11 Oct 2024 | 145. The Role of Secretory IgA in Regulating the Gut Microbiome and Protecting the Intestinal Lining | sIgA Testing & Causes of Low Levels | 00:20:24 | |
In this episode, we explore the critical role of Secretory IgA (sIgA) in maintaining intestinal health. We discuss how sIgA acts as a frontline immune defense, preventing pathogens from adhering to the gut epithelium and aiding in controlling microbial populations. Additionally, we dive into the implications of low and high sIgA levels - as indicated in a stool test, how sIgA levels relate to dysbiosis and Candida overgrowth, addressing underlying root causes, and tools for supporting healthy sIgA levels. Topics: 1. Introduction to Secretory IgA and its Functions - Overview of sIgA's role in mucosal immunity - Importance of sIgA in maintaining the gut's lining integrity - How sIgA regulates pathogenic microbes in the gut 2. Structure of the Gut Lining and Mucosal Layers - The intestinal lumen and the protective mucus layer - Layers of the intestinal wall: mucosa, submucosa, muscularis, and serosa - The epithelium within the mucosa: epithelial cells including goblet cells 3. The Mucus Layer and Its Protective Function - Composition of the mucus layer: mucins and other components - How the mucus acts as both a physical and biochemical barrier - Differences between the mucus layer in the small and large intestines 4. Secretory IgA: Location and Role in the Gut - Where sIgA is found in the mucus layer - Differences in sIgA concentration in the small vs. large intestine - Interaction between sIgA and mucins to trap pathogens 5. Production and Secretion of Secretory IgA - Plasma cells in the lamina propria and their role in sIgA production - Transport of sIgA across the gut epithelium via the polymeric immunoglobulin receptor (pIgR) - Secretory component (SC) and its role in protecting sIgA from degradation 6. Immune Functions of sIgA in the Gut - Binding and neutralizing pathogens - The process of immune exclusion - The role of sIgA in preventing pathogen adherence to epithelial cells 7. Low and High sIgA Levels and Gut Conditions - What low and high sIgA levels can indicate in a stool test - Gut conditions associated with abnormal sIgA levels (e.g., dysbiosis, Candida overgrowth, infections) - The impact of chronic stress and prolonged infections on sIgA levels 8. Root Causes for Low sIgA Levels - Addressing root causes and underlying infections - Lifestyle factors that support healthy sIgA levels - Nutrients such as Vitamin A and Zinc for supporting sIgA production 9. Probiotics & More to Support sIgA - Probiotics, prebiotics, and phages that enhance sIgA production - Individual gut health needs
Thank you to our episode sponsors: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. 2. Check out the TruAge Biological Age Test from TruMe Labs. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 11 Mar 2024 | 107. Emily Johnson, MS, RD, Research Lead at Veri - Insulin Resistance, How the Food Matrix & Macros Affect Blood Glucose & Insulin, Alternative Sweeteners, How to Track AND Interpret CGM Data, & More | 01:00:20 | |
We are honored to have Emily Johnson on the show today. Emily Johnson, MS, RD, is a registered dietitian with a Master's degree in nutrition interventions, communication, and behavior change from Tufts University. Her background includes clinical nutrition research, health writing, advising, and consulting within the tech sector. At Veri, she is the Research Lead, serving as the health and nutrition expert for the team. In this role, she ensures that Veri's app features, marketing materials, and publications are backed by rigorous scientific research. Topics:
Get a Veri CGM Here and use code VSM-THESYNTHESISOFWELLNESS Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 09 Aug 2024 | 134. Combatting Intestinal Dysbiosis Using the Power of Bacteriophages: Mechanisms of Action, T4D-Myoviridae Bacteriophage, SIBO & Dysbiosis, & More! | 00:18:50 | |
In this episode, we dive into the incredible role of T4D-Myoviridae bacteriophages in targeting Escherichia coli strains, highlighting their unique contractile tail structures that facilitate precise DNA injection into host cells. We explore the specific interactions between phage tail fibers and bacterial lipopolysaccharide receptors, illustrating the phage’s lock-and-key mechanism crucial for selective bacterial lysis. This discussion extends into the implications for combatting SIBO and enhancing gut microbiota balance while exploring the impressive scientific literature on phage-mediated modulation of gut flora and inflammatory markers. Topics: 1. Introduction to Bacteriophages - Explanation of what a bacteriophage (phage) is. - Importance of phages in research and their role in intestinal dysbiosis. 2. Bacteriophage Foundation - Description of bacteriophage structure: - Capsid and its genetic material (DNA or RNA). - Icosahedral head and its efficiency. - Types of phage tails and their functions: - Contractile tails: mechanism similar to a syringe. - Non-contractile tails: static structure for attachment. 3. Phage-Bacteria Interaction - Initial attachment to bacterial cell via tail fibers. - Specificity of attachment (lock and key mechanism). - Injection of genetic material into the bacterial cell. - Use of bacterial machinery to replicate phage components. 4. Phage Replication Cycle - Overview of the phage replication process within the host cell: - Integration and takeover of host cellular machinery. - Assembly of new phage particles. - Release of phages through lysis of the host cell. 5. Application - Potential of phages to selectively target and kill bacteria. - Benefits over broad-spectrum targeting. - Discussion of antibiotic resistance. 6. Diving into the Gut Microbiome - Connection between phages and the gut microbiome. - Discussion of specific phages like T4D-Myoviridae and their targets. - Relevance to SIBO (Small Intestinal Bacterial Overgrowth). 7. Case Studies and Research - Review of studies on phage impact on gut microbiota and inflammation. - Specific changes in microbiota observed in research (e.g., increase in butyrate-producing genera).
Thank you to our episode sponsor: Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 26 Jan 2024 | 97. Dietary Hacks to Prevent Insulin Resistance & Restore Function to the Cell Membrane (How to Safeguard Your Cell Membrane Phospholipids) | 00:24:35 | |
We are diving into all things lipids, their classifications, and their profound impact on cell membranes, insulin resistance, diet changes, and overall health. Included in the discussion: the critical balance between omega-3 and omega-6, providing valuable tips for maintaining a healthy lipid profile, becoming aware of lipid oxidation, and avoiding those sources of oxidized lipids. Topics: 1. Introduction - Discussion on Cell Membranes, Seed Oils, Lipid Classification, and Insulin Resistance 2. Lipid Classification - Overview of Lipids - Fatty Acids - Triglycerides - Phospholipids 3. Cell Membrane Composition - Lipid Bilayer - Primary Lipids in Cell Membrane - Phosphatidylcholine (PC) - Phosphatidylethanolamine (PE) 4. Impact of Omega-6 on Cell Membrane - Disruption of Lipid Packing - Increased Membrane Rigidity - Impaired GLUT4 Transporters and Insulin Resistance - Effects on Insulin Receptor Signaling 5. Omega-3 vs. Omega-6 in Membrane Fluidity - Location of Double Carbon Bonds - Omega-3 Supporting Fluidity and Signaling 6. Insulin Resistance and Omega-6 Intake - Inverse Relationship with Linoleic Acid - Ideal Omega-6 to Omega-3 Ratio (4:1) - Western Diet's High Omega-6 Ratio (16:1) 7. Tips for Balancing Omega-6 and Omega-3 - Grass-Fed (and Finished) vs. Grain-Fed Meat - Avoiding Seed Oils - The Importance of Avoiding Oxidized Lipids 8. Oxidation of Lipids - Susceptibility of PUFAs to Oxidation - Cooking with Stable Fats (Saturated, Monounsaturated) - Need for Whole Foods and Home Preparation 9. Specifics on Flaxseed - Omega-3 Profile and Susceptibility to Oxidation - Recommendations for Usage and Storage 10. Conclusion and Future Topics - Mention of Future Episode on Mitochondrial Function and "detoxing your membranes" of these lipids
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 15 Jan 2024 | 93. Dr. Susie Gronski - Men’s Pelvic & Sexual Health, Understanding Pelvic Pain, & Treating The Underlying Cause(s) | 00:44:24 | |
We are excited to have Dr. Susie Gronski on the podcast today. With more than a decade of expertise in the field of men's pelvic and sexual health, our guest today, Susie, is a licensed Doctor of Physical Therapy. She's also a Certified Pelvic Rehabilitation Practitioner, a certified Sexuality Educator, a University of Michigan trained sexuality counselor, and an internationally recognized teacher and author, with one of her notable works being "Pelvic Pain: The Ultimate Cock Block" and much more. Topics: 1. Introduction - Speaker's journey into specializing in pelvic health for men - Motivation behind choosing this niche 2. Understanding Pelvic Pain - Defining pelvic pain - Common causes of pelvic pain in men - The mystery surrounding pelvic pain 3. Unique Approach to Treating Pelvic Pain - Speaker's approach to treatment - The role of education in the healing process 4. Common Misconceptions and Myths - Identifying misconceptions about pelvic pain in men - Impact of misunderstandings on treatment-seeking 5. Lifestyle Factors and Pelvic Pain - Influence of diet on pelvic health - The role of exercise in preventing or exacerbating pelvic pain - Stress and its connection to pelvic issues 6. Preventive Measures and Daily Practices - Tips for maintaining good pelvic health - Preventive measures for men to consider 7. Pelvic Floor Exercises and Therapies - Overview of pelvic floor exercises and therapies - Importance in managing and preventing pelvic issues
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 02 Aug 2023 | 23. Metal Hypersensitivity with Shari Guess - Symptoms & Tests for Metal Hypersensitivity + Some Sneaky Ways That Unwanted Metals are Getting into Your Body | 00:43:28 | |
Welcome to another episode of The Synthesis of Wellness Podcast! Today, we are joined by Shari Guess who is an extremely inspiring individual who has overcome a myriad of health conditions, all ultimately stemming from her metal hypersensitivity reactions. Topics: 1. Prevalence of metal hypersensitivity in the general population 2. Diagnostic testing for metal allergies 3. The roadmap to receiving a metal allergy diagnosis 4. Next steps after identifying metal reactivity 5. Eliminating trigger foods to help manage metal hypersensitivity 6. Creating a metal-friendly environment for metal hypersensitivity management 7. Recognizing and minimizing symptoms of metal hypersensitivity 8. Lastly, a reminder to be vigilant in uncovering hidden metals present within the body
Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness, or use the link: https://www.instagram.com/synthesisofwellness/ Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 24 Nov 2023 | 72. Beta-Glucans for Immune Support, The Ayurvedic Agni Sara Exercise for Digestive Support, & 2 Unique Ways to Induce The Acute Relaxation Response - 3 Topics for Today! | 00:29:45 | |
In today's episode, we're exploring 3 different topics. First, we'll unravel the intriguing world of beta-glucans and their dual role in regulating the immune system. Then, we'll venture into the ancient practice of Agni Sara, a yoga exercise renowned for strengthening digestive organs. Finally, we'll unveil two unique methods to trigger the acute relaxation response, encouraging parasympathetic activity. Stay tuned for this 3-topic episode! Topics: 1. Agni Sara Exercise - Definition and Purpose - Origin and Traditional Yoga Practice - Physical and Energetic Benefits - Research Study on Agni Sara - Study Involving 12 Volunteers - Ultrasound Examination of Superior Mesenteric Artery - Increase in Blood Flow and Digestive Function Improvement - Traditional Agni Sara Exercise Instructions 2. Beta-Glucans - Definition and Classification - Interaction with the Immune System - Immune System Review - Role of Dectin-1 Receptors - Immune-Boosting Effects - Stimulation of Immune Cells, Phagocytosis, & Antibody Production - Modulation of Inflammation - Stimulation of Interleukin 10 - Balancing Immune Response - Food Sources of Beta-Glucans - Mushrooms Rich in Beta-Glucans - Mushroom Extract Supplements 3. Tibetan Singing Bowls and the Acute Stress Response - Introduction to Tibetan Singing Bowls - Composition and Original Use - Sound Characteristics - Benefits of Tibetan Singing Bowls (TSB) - Impact on Distress, Anxiety, Depression, and More - Physiological Effects on Heart Rate, Respiration, and More - Research Study on Acute Relaxation Response - Comparison of TSB and Progressive Muscle Relaxation (PMR) - Evaluation of HRV, Alpha Power Band (EEG), and Anxiety - Study Findings - Promotion of Acute Relaxation Response by TSB and PMR - TSB's Pronounced Effect on HRV Parameters and Alpha Band Activity - Acknowledgment of Individual Preferences for Relaxation Techniques - Emphasis on Research-Backed Tools for Stress Reduction
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 23 Oct 2024 | 147. Mindfulness, Gratitude, Manifestation, Habit-Formation, & More with Ron & Carri, The Co-Founders of The Sparkle Revolution App | 00:46:33 | |
We are honored to be joined by Carri Norton and Ron Butterworth, the Co-Founders of the Sparkle Revolution App. Carri is an accomplished professional in software application development, with experience across various industries such as educational software, solar monitoring, energy management, and HVAC digital solutions. Starting her career as a software developer, she progressed into management and leadership roles, contributing to both startups and Fortune 500 companies. Her passion lies in creating user-centric software solutions that enhance customer experiences and make lives better. Ron’s professional career has been that of a hardware design engineer. He has had the opportunity to work on projects based in education, solar energy, agriculture, and augmented reality, to name a few. Together they were thrilled to combine their expertise with personal passions and launch Sparkle Revolution. Topics: 1. Motivation to Create the App / Personal Journeys for Ron and Carri - Inspiration behind the app - Personal stories of Ron and Carri - Introduction to the app and its 4 "foundations" 2. How the App’s Foundations Relate to Health - Overview of the 4 foundations - Impact of these foundations on mental, emotional, and physical health 3. Science and Studies on Mindfulness and Gratitude - Research on mindfulness practices - Scientific evidence on the benefits of gratitude 4. Examples of Mindfulness Exercises - Simple exercises for beginners - Techniques used to enhance daily mindfulness 5. Manifestation and Visualization Techniques - How manifestation works on a psychological level - Rewiring the brain to embrace future opportunities 6. Personal Examples of Manifestation in Action - Stories from Ron and Carri’s lives - Real-world outcomes from practicing manifestation 7. Strategies for Integrating Mindfulness and Building Habits - Daily habits to foster mindfulness - Tips for sustainable habit formation 8. Overview of the Sparkle Revolution App - How the app works - Features and functionality - Where to download the app 9. Social Handles, Website, and Other Resources - Social media platforms - Official website and contact info - Additional tools or resources for further exploration To learn more and get the app, check out www.sparklerevolution.com Search for Sparkle Revolution on the Apple or Android stores. Visit them on social media @SparkleRevolutionApp Take advantage of an introductory offer! Use code CHLOE60 to get 60% off an annual subscription. Studies & Articles Mentioned:
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| 15 Mar 2024 | 108. Energy Deficiency in Lyme & Mold - How Biotoxins Starve Brain Cells of Energy, Why The Adrenal Glands & HPA Axis Are Dysfunctional, & Researched Tools to Help Mitigate The Energy Deficiency | 00:28:04 | |
We explore how biotoxins impair cellular function and induce neuroinflammation, leading to systemic inflammation, chronic fatigue, and mitochondrial dysfunction. We also cover how biotoxins disrupt the HPA axis, affecting the body's stress response and adrenal function. Additionally, the conversation presents strategies to mitigate this energy deficiency and combat fatigue in the context of CIRS (lyme & mold). 1. Introduction to Biotoxin Illness - Definition and overview of biotoxins - Sources of exposure: Inhalation, contaminated water, ingestion, tick and spider bites - Genetic susceptibility and immune system's role 2. Mechanisms of Biotoxin Impact on Cellular Function - Biotoxins as fat-soluble molecules - Disruption of cell membranes and cell function - Ionophore-like structure of biotoxins 3. Specific Targets and Effects of Biotoxins - Predilection for fatty tissues and nervous system - Neurotoxin effects of Lyme disease - Impact on cardiovascular and gastrointestinal sites 4. Cellular and Systemic Consequences of Biotoxin Exposure - Impairment of mitochondrial function - Alterations in cellular signaling and ion concentrations - Decreased ATP production and its implications -- Veri -- 5. Neuroinflammation and Its Outcomes - Connection between cellular disruption and neuroinflammation - Effects on the adrenal glands - Role in chronic fatigue and energy depletion 6. Biotoxins and the HPA Axis - Overview of the HPA axis and its dysfunction due to biotoxins - Cytokine stimulation and hormonal cascades - Adrenal fatigue or insufficiency and altered cortisol production --Leela Quantum Tech-- 7. Strategies for Mitigating Cellular Energy Deficiency - Importance of a comprehensive treatment protocol - Mitochondrial support strategies - Adrenal gland support and circadian rhythm normalization 8. Mitochondrial Support Tools - Red light therapy - Dietary adjustments and supplements (e.g., Nicotinamide Riboside, CoQ10) - Importance of professional guidance in using mitochondrial support tools 9. Supporting the Adrenal Glands and Overall Energy - Adjustments to normalize circadian rhythm - Adrenal health Get a Veri CGM Here and use code VSM-THESYNTHESISOFWELLNESS Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 17 Nov 2023 | 69. Optimizing Oxygenation (Important for Biotoxin Illness Recovery & Chronic Illness in General) - 13 Strategies + 1 Way to Track Levels | 00:28:15 | |
In today's episode, we are diving into all things oxygen. Low levels of cellular oxygen are much more common than they seem (especially with the increased prevalence of biotoxin illness ie. mold/lyme/etc... and other chronic inflammatory conditions). Oxygen truly keeps our bodies alive; this episode is a must-listen! Topics:
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 27 Sep 2023 | 47. Dr. Terry Wahls - Multiple Sclerosis, How to Implement The Wahls Protocol, New Research, & More! | 00:58:05 | |
Today, we are joined by the inspirational Dr. Terry Wahls. Dr. Terry Wahls is a world-renowned researcher, particularly for her work on lifestyle interventions for treating progressive health problems. Having been diagnosed with secondary progressive multiple sclerosis, she designed the "Wahls Protocol," a combination of nutritional and other wellness-related strategies, which she credits for significantly improving her own health. Dr. Wahls' journey from wheelchair-bound to biking and her revolutionary approach to treatment has inspired many in the MS community and beyond. This episode is filled with emotion and inspiration, and I know you'll love it as much as I did! Topics: 1. Personal Story and Healing Journey: - Background on experiencing multiple sclerosis and trigeminal neuralgia. - Key "aha" moments that steered the course of personal health and subsequent research. 2. Deep Dive into Clinical Research & Trials: - Overview of key clinical research findings and their implications. - Insights into the "Efficacy of Diet on Quality of Life in Multiple Sclerosis" trial. - Differences between diet and drug studies. - Understanding the transition of microglia and astrocytes into repair mode. - The influence of diet and lifestyle on microglia and astrocytes. 3. The Wahls Protocol: Steps, Diets, and Supplements: - Dietary Foundations: The core dietary principles of the Wahls Protocol. - Elimination of certain foods. - Inclusion of nutrient-dense foods. - Levels of The Wahls Protocol: - Supplement Recommendations: Key supplements and their role in supporting health. - Importance of B vitamins. - Role of Omega-3 fatty acids. - Zinc to Copper ratio - Supplements for glucose management - Lifestyle Adjustments: Additional practices and habits complementing the protocol. - Monitoring and Adjustments: How to assess progress and make necessary modifications. Thank you so much for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
The Provided Information for Dr. Wahls' Research Study: EDQ-MS: Efficacy of Diet on Quality of Life in Multiple Sclerosis. https://terrywahls.com/msstudy/
"You are invited to participate in a research study to evaluate the effects of three diets — Modified Paleolithic Elimination diet, Time Restricted Olive Oil-based Ketogenic diet, and your usual diet with information about the USDA Dietary Guidelines for Americans. Participants in the usual diet group will be encouraged but not required to follow the Dietary Guidelines for Americans diet. Quality of life, including long term effect on motor and vision function, fatigue, mood, and disease activity will be assessed by online surveys, study participant tasks, and brain imaging. The study will be conducted at the University of Iowa Hospitals and Clinics. Patients will be followed for two years. In person visits will occur at baseline (month 0), month 3, and end of study (month 24). Complete this survey to see if you are eligible. https://redcap.icts.uiowa.edu/redcap/surveys/?s=JX73EYRJNPF9MHRR If you have any questions about what it means to be part of a research registry, please feel free to contact a member of the study team by email (MSDietStudy@healthcare.uiowa.edu)" | |||
| 11 Oct 2023 | 53. Dana Claudat - Feng Shui Master - How to Change Your Environment to Attract What You Want in Life, Embracing Change, & Adopting New Mindsets | 00:57:22 | |
I am so honored to be joined by Dana Claudat, a visionary in the realm of modern Feng Shui. As the founder of The School of Intention Feng Shui Method and Certification Program, Dana has, over the past 18 years, carved a distinctive approach to Feng Shui centered around Infinite Possibility, Creativity, and Empowerment. Instead of merely hoping for fortunate outcomes, Dana guides her clients in crafting them daily. Her significant contributions have not gone unnoticed. Dana has been recognized as one of the 100 Women To Watch In Wellness by Mind Body Green & Athleta. Moreover, in 2017, when Beverly Hills embraced the title "City of Wellth," Dana stood out as the representative for the Wellth Pillar "Restore." This episode will really allow you to embrace change, find clarity, attract what you want, and achieve your goals! I absolutely loved talking to Dana! Topics: 1. Introduction to Feng Shui - Definition & Dana's approach 2. Governing Principles of Feng Shui - Key concepts and practices 3. The Bagua Map - Its significance in Feng Shui - Using the map for space organization 4. Concept of Chi (Qi) in Feng Shui - Strategies to amplify and nurture chi within the body 5. Optimizing Surroundings for Chi Flow - Enhancing chi flow in occupied spaces 6. Energy Drainers in Our Environment - Common energy-depleting elements 7. Energy Givers in Feng Shui - Examples of chi enhancers 8. Influence of Colors and Organization - The relationship with energy and mood - Impact on chi enhancement 9. Mindset Shifting 10. Embracing Change is What Feng Shui is All About - Walking through the fear Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 01 Jan 2024 | 87. Carrie Bennett - Quantum Biology - How Light, EMFs, Structured Water, & Toxins Affect the Mitochondria | 00:43:51 | |
I absolutely loved this conversation, and I resonate greatly with her thought process! Carrie has multiple degrees in biology, nutrition, and bodywork, and her relentless enthusiasm to learn has made her one of the leading educators in the emerging field of quantum biology. She combines deep research and clear explanations of the complex quantum mechanisms at play in the human body to teach people how to use light, water, and nature to thrive. Carrie is a sought-after speaker and guest lecturer. She currently sees clients in her online practice. She is also the lead faculty member and on the Board of Advisors for the Quantum Biology Collective, the world’s premier certification for Applied Quantum Biology in clinical practice. Topics: 1. Quantum Biology and Cellular Function - Explanation of Quantum Biology - Role of Quantum Biology in Understanding Cellular Function 2. Light's Influence on the Body - Connection between Quantum Biology and Light - Impact of Light on Circadian Rhythms - Influence of Light on Mitochondrial Function 3. Optimal Light Exposure for Cellular Health - Specific Types of Light to Consider - Optimal Times for Light Exposure 4. Cellular Hydration and Its Factors - How Cells Become Hydrated - Deuterium and Its Impact on Hydration - Exclusion Zone Water and Effective Hydration 5. The Impact of Proper Hydration - Relationship between Hydration and Detoxification - Hydration's Role in Managing Edema - Hydration and Its Effect on Lymphatic Flow 6. Electromagnetic Fields (EMFs) and Cellular Health - How EMFs Affect Cells - EMFs' Influence on Mitochondria - The Modern Environment and Increasing EMF Exposure Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 17 Jan 2025 | 160. The Gut-Immune Axis | Mast Cells & Small Intestinal Bacterial Overgrowth, and a Brief Discussion on Mast Cell Activation Syndrome | 00:16:52 | |
In this episode, we detail the gut’s intricate immune defenses, emphasizing the role of mast cells in inflammation and immune signaling. We extend this conversation to Mast Cell Activation Syndrome briefly going through potential triggers, tests, and symptoms. Finally, we examine the bidirectional relationship between MCAS and Small Intestinal Bacterial Overgrowth (SIBO), illustrating how mast cell mediators and microbial byproducts can drive a cycle of chronic inflammation and increased intestinal permeability. Topics: 1. Introduction to the Gut-Immune Axis - Focus: mast cells, small intestinal bacterial overgrowth (SIBO), and mast cell activation syndrome (MCAS). 2. Anatomy of the Gastrointestinal Lining - Intestinal lumen, microbiome, mucus layer, epithelial monolayer, tight junctions, and lamina propria. - Role of the smooth muscle and deeper layers supporting the mucosal structures. 3. Gut-Associated Lymphoid Tissue (GALT) - Peyer’s patches, mesenteric lymph nodes (MLNs), isolated lymphoid follicles (ILFs), intraepithelial lymphocytes (IELs), and dispersed immune cells in the lamina propria. - Function of GALT. 4. Peyer’s Patches and Antigen Exposure - Location and function of Peyer’s patches. - Role in antigen sampling and processing. 5. Immune Cells in the Lamina Propria - Overview of interspersed immune cell populations. 6. Focus on Mast Cells - Key roles of mast cells in the gut’s innate immune system. - Locations with a focus on the lamina propria. 7. Mast Cell Mediators - Histamine - Tryptase: tissue remodeling, impact on intestinal permeability. - Cytokines, prostaglandins, and leukotrienes. 8. Mast Cell Activation Syndrome (MCAS) - Overactivation of mast cells and excessive release of inflammatory mediators. - Effects on gut barrier function. - Pathological behavior due to altered activation thresholds, receptor expression, and tissue environment changes (not resulting from an increased number of mast cells). 9. MCAS Symptoms and Systemic Effects - Abdominal pain, cramping, bloating, diarrhea, and nausea. - Systemic symptoms: skin reactions, respiratory and cardiovascular effects, neurological impacts. 10. Triggers and Conditions Associated with MCAS - Environmental toxins, infections, stress, chemical exposures. - Hypermobile Ehlers-Danlos syndrome (hEDS), dysautonomia (e.g., POTS). 11. MCAS Testing - Testing limitations: variability in mediator release and transient nature of mast cell degranulation. - Serum tryptase, urinary N-methylhistamine, plasma heparin levels, specific cytokines like IL-6, and more. 12. Small Intestinal Bacterial Overgrowth (SIBO) - Overview of SIBO. - Slow motility, low stomach acid. 13. Interaction Between SIBO and Mast Cells - SIBO-induced mast cell activation. - Cycle of inflammation, increased intestinal permeability, and gut dysfunction. 14. Conclusion - Recap of the intestinal anatomy and immune cell focus. - MCAS triggers, symptoms, and testing. - Connections between SIBO and MCAS, emphasizing an inflammatory cycle. Thank you to our episode sponsor: 1. Check out Ulyana Organics' Tallow Wild Yam Cream and Healing Facial Oil, and use code CHLOE10 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 31 Jan 2024 | 98. Dr. Gerald Pollack - 4th Phase of Water (EZ Water) - What it is, How it Acts Like a Battery, & How to Increase It Within Our Cells | 00:50:18 | |
We are honored to have Dr. Gerald Pollack as a guest on the podcast. He is a renowned scientist at the University of Washington in Seattle, the Founding Editor-in-Chief of WATER: A Multidisciplinary Research Journal, and the Executive Director of the Institute for Venture Science. Dr. Pollack's contributions to the field have earned him international recognition as a distinguished speaker and author. Topics: 1. Introduction to EZ Water - Definition and Overview - Differences from Ordinary Water 2. Phases of Water - EZ Water's Place in the Spectrum 3. Benefits and Unique Properties of EZ Water - Increased Density - Enhanced Hydration - Electrical Charge 4. Interaction with Cellular Function - Role in Cell Hydration - Cellular Functions - Potential Implications for Health 6. Accessing and Creating EZ Water - 6+ Strategies to Increase EZ Water in the Body 7. Future Research and Applications - Exciting Areas of Research - Potential Impact on Health and Industry Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 16 Feb 2024 | 102. Hacking the Mitochondria - How Chlorophyll Metabolites + Sunlight May Stimulate ATP Production & Enhance Longevity, & My Specific Protocol | 00:24:32 | |
Exploring the science behind chromophores, we unravel how these molecular entities selectively absorb specific wavelengths of light and can become "activated." As a result of this photoactivation, chlorophyll metabolites within the human body, when combined with sunlight exposure, MAY, according to several studies, have interesting and profound implications for cellular energy production and longevity. Topics: 1. Introduction to the Topic - Importance of ATP production - When chromophores are stimulated by light? - Accessibility to red light therapy panels - Enhancing sunlight absorption 2. Understanding Chromophores - Definition and function - Molecular structure and electron configuration - Selective absorption of wavelengths - Example: Methylene blue 3. Differentiating Types of Reactions - Focus on chlorophyll metabolites' integration within cells and mitochondria 4. Role of Chlorophyll Metabolites in ATP Production - Overview of ATP production in mitochondria - Interaction of chlorophyll metabolites with CoQ10 - Photoreduction of quinones and, specifically CoQ10 in the electron transport chain 5. Specific Chlorophyll Metabolites and ATP Synthesis - Focus on chlorin p-a - Activation through photon absorption - Review of the mechanism of ATP synthesis stimulation 6. Light Requirements for Chlorophyll Activation - Necessary wavelengths for activation (around 670 nm) - Comparison of red light therapy and natural sunlight - Evidence of chlorophyll activation under sunlight. Is natural sunlight enough to activate the metabolites in this case? 7. Penetration of Light in Biological Tissues - Attenuation of light in human and animal tissues - Penetration depth in various tissues 8. Effects of Chlorophyll on Cellular Biology - Increase in ATP in isolated animal mitochondria - Extension of lifespan in worms (up to 17%) 9. Conclusion and Personal Protocols - Need for further research - Personal supplementation protocols - Personal integration of chlorophyll supplementation with sun exposure for enhanced ATP production.
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 04 Dec 2023 | 76. Dr. Yusuf Saleeby - Chronic Lyme Disease - Botanicals, Peptide Stacks, Immune-Supporting Mushrooms, IV Hydration, & More! | 00:50:35 | |
We're thrilled to have Dr. Yusuf Saleeby on the podcast. He's a highly experienced medical professional, specializing in Integrative & Functional Medicine at Carolina Holistic Medicine in South Carolina. With a background in emergency medicine and various medical leadership roles, Dr. Saleeby brings a wealth of expertise to his current practice. He's also an active member of several prominent medical organizations including ILADS, IFM, A4M, ACAM, and the American Telehealth Association, where he focuses on Functional Medicine, research, and innovative healthcare models. If you are looking for an episode to provide insight on a variety of tools for chronic lyme disease, then this is the perfect episode! So many gems of information! Topics: 1. Lyme Disease Presentation and Diagnosis - Common Symptoms and Challenges - Under-diagnosis and Misdiagnosis Issues 2. Laboratory Testing for Lyme and Co-infections - Limitations of Standard Testing - The Role of Biomarker Laboratory Tests 3. Modified Treatment Protocols - Dr. Cowden's Approach - Dr. Buhner's Approach - Differences from Conventional Treatment 4. Low-Dose Naltrexone (LDN) in Lyme Treatment - Potential Benefits - Mechanisms of Action 5. Peptides in Chronic Lyme Treatment - Types of Peptides Used - Efficacy and Benefits 6. Timing and Phases of Peptide Administration - When Peptides Are Most Beneficial - Optimal Timing for Treatment 7. Some Aspects of His Treatment Protocol - Immune Support (Mushrooms, LDN, Thymosin Alpha-1) - Gut Support - Botanical Therapies (e.g., Cat's Claw) His Clinical website: www.CarolinaHolisticMedicine.com His Substack: www.jpsaleebymd.substack.com
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 27 Oct 2023 | 60. How I Make My Own NAD+ Patches, Using Electrical Charge to Drive NAD+ Into The Body, & Causes/Effects of NAD+ Depletion | 00:34:52 | |
Today, I am sharing how I make my own NAD+ patches (saving hundreds of dollars and avoiding NAD+ solution storage degradation). I also share the science behind electrochemical cells and how specialized patches use electrical charge to drive NAD+ into the body. Topics: 1. Introduction - Addressing Unprofessional Individuals - Breaking Stereotypes and Self-Limiting Beliefs 2. Background: My NAD+ Patches - The High Cost of Commercial NAD+ Patches and IV Drips - Benefits of Transdermal NAD+ Delivery - NAD+ in Energy Metabolism - Role of NAD+ in Glycolysis - NAD+ Utilization in the Krebs Cycle - Accumulation of NADH and Implications - The Appeal of NAD+ Therapy for Energy Metabolism 3. Creating My Own NAD+ Patches - Sourcing High-Purity NAD+ Powder - Solubility of NAD+ in Water - Preparing NAD+ Solution - Use of Iontophoresis Patches for Transdermal Delivery - Introduction to Electrochemical Cells - Role of Anode and Cathode - Electron Flow and Ion Exchange - Applying the NAD+ Solution to Patches - NAD+ Patch Dosage Rate and Duration 4. Cost Comparison - Expenses for My NAD+ Patches - Comparing My Costs to Commercial Patch Kits - Importance of Working with a Licensed Physician
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 19 Jan 2024 | 95. Hacking Your Home for Better Health - Air Quality, HEPA Filters, Carbon Filters, AHPCO, HVAC Hacks, Cleaning, & More | 00:22:41 | |
I explore the critical role of your home environment in your overall health. We'll delve into topics such as enhancing air quality with HEPA and activated carbon filters, the innovative Advanced Hydrated Photocatalytic Oxidation (AHPCO) technology, and essential HVAC tips and cleaning tips for creating a healthier living space. Topics: 1. Introduction - Importance of home environment for health - Focus on house care and creating a safe and nurturing ecosystem 2. Moving into a New Home - Prompt for the episode - Opportunity to discuss home care 3. Air Quality - Types of filters and air purification methods - HEPA filters - Activated charcoal/carbon air filters - Advanced Hydrated Photocatalytic Oxidation (AHPCO) technology 4. HEPA Filters - Filtering effectiveness - Limitations - Different classes of HEPA filters 5. Activated Charcoal/Carbon Filters - Filtering capabilities - Synergy with HEPA filters 6. Advanced Hydrated Photocatalytic Oxidation (AHPCO) - How AHPCO technology works - Effectiveness in reducing bacteria, viruses, and mold - Installation options 7. Quick Tips for Healthier Air - Importance of good airflow - Managing indoor humidity - Thermostat fan settings: "On" vs. "Auto" - Cleaning surfaces and using VOC free cleaners - Bedding and floor maintenance: HEPA vacuum 8. Conclusion - Mention of a possible part 2 on clean air and home health tips
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 10 Jan 2024 | 91. Dr. Jay Goodbinder - Strategies to Optimize Your Epigenetics, Testing, IVs, Peptides, & More! | 00:53:05 | |
We are honored to welcome Dr. Jay Goodbinder to the podcast. Dr. Goodbinder is a distinguished graduate who earned valedictorian honors at Cleveland Chiropractic College. With an impressive background in functional medicine, endocrinology, immunology, biochemistry, physiology, and epigenetics, he is an international speaker renowned for his expertise in reversing severe diseases. Topics: 1. Epigenetics vs. Genetics - Epigenetics overview - Introduction to DNA methylation 2. Genetic Predisposition & Chronic Conditions - Genetic influence on chronic health issues 3. Monitoring Health with Genetic Predisposition - Importance of tracking biomarkers - Practical example 4. Nutrition, Genetics, and Epigenetics - Interplay between nutrition and genetic predisposition 5. Optimizing Wellness with Biohacks - Peptides, IVs, NAD for wellness & epigenetics 6. Strategies for Enhanced Epigenetics - Lifestyle changes - Environmental factors - Supplements & interventions
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 08 Nov 2023 | 65. Judy Wilkins-Smith - Decoding Your Emotional DNA, Letting Go of Limiting Beliefs & Inherited Patterns, & Embracing The Biggest Life You Could Ever Imagine | 00:52:05 | |
This was one of my favorite conversations! Today, we are joined by Judy Wilkins-Smith. Judy, the founder of the U.S. company System Dynamics for Individuals & Organizations, stands out as an acclaimed expert in international organizational, individual, and family patterns, as well as a systemic coach and trainer. Her illustrious clientele includes industry giants like NASA, Microsoft, Pfizer, and JP Morgan, among many others. With an unwavering passion for unlocking human potential, fostering visionary leadership, and driving positive global change, Judy revolutionizes the field. She leverages her profound understanding of relational dynamics in both personal and organizational contexts, elevating the revered healing methodologies of Systemic Work and Constellations into transformative tools for personal growth and organizational metamorphosis. Truly, if you need some mid-week motivation, this IS THE EPISODE for you! I loved it so so much! Topics: 1. Decoding Emotional DNA - Understanding the concept - Implications for individual identity 2. Influence of Inherited Family Patterns - Recognizing their existence - Identifying their impact on present circumstances 3. Addressing Limiting Inherited Patterns - Steps to identify - Techniques to process and transform them 4. Imposter Syndrome and Family Patterns - Understanding the connection - Overcoming imposter syndrome 5. Transformation Stories - Real-life cases - Impact of addressing inherited patterns and imposter syndrome 6. Path to Wealth and Abundance Mindset - Laying the groundwork - Emotional Blockages - Necessary processing for mindset shift 7. Actionable Tips - Immediate steps for change
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 27 Jul 2023 | 21. Q & A - The Connection Between Oral Dysbiosis & Gut Dysbiosis Plus a Brief Convo on GLP-1, Butyrate, & Berberine | 00:26:55 | |
Welcome to another episode of The Synthesis of Wellness podcast! This is another info-packed episode focused on the oral microbiome and the connection between GLP-1 agonists, berberine, and butyrate! Thanks for tuning in! Topics: - A few updates and reminders of what I stand for - Is there a link between poor oral health and poor gut health? - Have pathogenic oral microbes been found in the gut's of individuals with dysbiosis? - How to keep your oral microbiome balanced and free of pathogens? - My favorite products and routines for taking care of my oral microbiome. - What are GLP-1 agonists, and why are they so popular right now? - What is berberine, and how is this similar to "Ozempic" or semaglutide? - How can you support your body's own natural production of GLP-1 without drugs like Ozempic and supplements like berberine? Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness, or use the link: https://www.instagram.com/synthesisofwellness/ Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in, and we'll see you in the next one!
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| 15 Sep 2023 | 42. GHK-Cu & AHK-Cu Copper Peptides for Skin Care (Peptides Episode) - Skin Anatomy, Copper's Effect on Collagen & Elastin, Increasing Skin Cell Turnover Rate, & Making Your Own GHK-Cu Serum | 00:37:09 | |
This episode dives deep into the anatomy of the skin including it's cellular makeup and the important proteins and lipids produced by these skin cells. Then, we explore copper peptides, what they do to these fibroblasts and keratinocytes (skin cells). And, finally, we go through my n=1 experiment and examine how I make a skincare serum using GHK-Cu. This episode is where science meets peptides meets skincare! You won't want to miss it! Topics: 1. Introduction - Overview of the skincare discussion surrounding copper peptides. 2. Anatomy of the Skin - Brief description of the skin's multi-layered structure and its essential role. - Epidermis: Description of the outermost protective shield. - Stratum corneum: The outermost layer of the epidermis. - Stratum lucidum: Only found in the palms and soles. - Stratum granulosum: Maturing keratinocytes. - Stratum spinosum: Contains several layers of keratinocytes. - Stratum basale: Deepest layer with keratinocyte production. - Summary of the epidermis sublayers and their functions. - Dermis: Two distinct sublayers. - Papillary dermis: Uppermost layer, interlocking with the epidermis. - Reticular dermis: Dense, deep layer providing skin elasticity and strength. - Discussion on crucial skin components: - Keratin and keratinocyte-derived lipids: Their roles and importance. - Collagen: Its role in skin health and appearance. - Elastin: Essential for skin's elasticity and resilience. 3. Skin-Aging and Cosmetic Peptides - Delving into the aging process of the skin. - Aging effects: How they manifest and the science behind them. - Introduction to cosmetic peptides: Their increasing role in skincare. - Copper's significant role in skin health. - How copper stimulates dermal fibroblasts. - Copper's role in collagen and elastin production. - How copper stabilizes the dermal extracellular matrix. - A deeper dive into copper peptides: AHK-Cu and GHK-Cu. - Their general properties and amino acid structure. - The biological activities associated with these peptides. - AHK and GHK's specific roles in skin health and regeneration. - A comparison between AHK and GHK. 4. Personal Experimentation with Copper Peptides - A detailed example: Formulating a skincare product with 1% GHK-copper peptide serum. - Steps and ingredients to formulate the serum - pH compatibility 5. Conclusion - Consulting a licensed physician before beginning any skincare regimen. - Emphasizing the significance of personal experimentation and observation. Thanks so much for tuning in! Pre-Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" and email thesynthesisofwellness@gmail.com a screenshot of the order confirmation to enter the GIVEAWAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 01 Sep 2023 | 36. Thymosin Beta-4 / TB-500 Peptide for Hair Growth (Peptides Episode) + How I am Experimenting With Infrared Light Therapy for My Gut Microbiome | 00:33:06 | |
Welcome to another episode of The Synthesis of Wellness Podcast! Today, we are talking all about my latest n=1 experiment: using the FlexBeam (a red and infrared light therapy device) on my gut microbiome. Then, we transition into cosmetic peptides with an emphasis on TB-500 for stimulating and accelerating hair growth! Thanks so much for tuning in! Topics: 1. Introduction - Biohacking congress in Miami - Invitation to connect with me for meet-ups and ticket discounts 2. Red and Infrared Light Therapy - Introduction to the red light and infrared therapy device (FlexBeam) - Description of the device's features and capabilities - Explanation of its ability to penetrate up to 10cm within the body - Interest in exploring the impact of red and near-infrared light on the gut microbiome - Self-experiment! 3. Scientific Context - Definition of Photobiomodulation and its healing properties - Mention of studies exploring the effects of light therapy on the gut microbiome - Discussion of the impact of Photobiomodulation on gut microbial diversity 4. Human Microbiome Studies** - Mention of preliminary unpublished work using Photobiomodulation on the human microbiome - Increases in Akkermansia muciniphila, Bifidobacterium sp., and Faecalibacterium sp. - Impact on the Firmicutes:Bacteroides ratio as an indicator of gut health 5. Personal Experiment - Experiment using the FlexBeam device with both red and infrared light - Explanation of the wavelengths used in the experiment - Description of the experiment's frequency and duration - Excitement about the potential results and anecdotal observations 6. Transition to Cosmetic Peptides - Introduction to the topic of cosmetic peptides - Focus on thymosin beta-4 and its various uses 7. Thymosin Beta-4 for Hair Growth - Background information on thymosin beta-4 - Discussion of the hair follicle structure and growth cycle - Explanation of the anagen, catagen, and telogen phases - Role of stem cells in the bulge area during anagen phase - Overview of the acceleration of stem cell migration due to thymosin beta-4 8. Stem Cell Migration and Hair Growth - Significance of stem cell migration in hair follicle growth - Natural expression of thymosin beta 4 during anagen phase - Migration of cells from the bulge to the bulb region 9. Effectiveness and Administration - Discussion on the effectiveness of thymosin beta-4 for hair growth - Mention of a study using topical thymosin beta-4 on shaved rats - Role of angiogenesis in promoting blood flow to the scalp - Connection between inflammation and decreased blood flow 10. Application Methods - Topical application in most studies - Mention of subcutaneous injections for broader repair/regeneration - Emphasis on working with licensed physicians 11. Conclusion - Acknowledgment of individual variability in hair growth approaches - Reminder of the importance of addressing root causes of hair loss Thanks so much for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 01 Jun 2023 | 12. Biohacking with Brittany - Brittany's Current Biohacking Tech, Tests, Supplements, & More! | 01:00:59 | |
Welcome to the 12th episode of The Synthesis of Wellness Podcast! We've got Biohacker Brittany Ford as a guest on today's episode, and we talk all things biohacks, routines, tech, testing, supplements and so much more! Topics: - Brittany's story - What is biohacking? - A little bit of my story - Opinions on gut tests: Viome, Genova GI Effects - Wellness vs. biohacking (data driven) - At-home hormone testing - At-home HRV wearables, how to interpret and use HRV data - Oura ring - more than HRV - Opinions on continuous glucose monitors - Ways to identify food sensitivities: IgG testing? Blood glucose spikes? HRV testing? Gut panels? - Biotoxin illness: CIRS - Infrared sauna, PEMF, cold therapy, red light therapy - Daily routine to reduce stress and optimize wellbeing - Bedtime routine for optimizing sleep Thanks so much for tuning in! Resources: Visit my shop page on synthesisofwellness.com and use code CHLOEP for 30% off Silver Biotics' products! | |||
| 08 Mar 2024 | 106. SS-31 Peptide (Peptides Episode) Deep Dive - How it Works on Mitochondrial Dysfunction, What it Does for Exercise Performance, Current Studies, & More | 00:27:25 | |
In this episode, we explore the intricate structure and functions of mitochondria, focusing on the electron transport chain complexes and the generation of reactive oxygen species. We delve into the significance of lipid composition in maintaining mitochondrial integrity, the detrimental effects of ROS-induced lipid peroxidation, and how SS-31 can prevent this damage. Additionally, we discuss the potential therapeutic implications of SS-31 peptide not only on the cellular level in mitigating mitochondrial dysfunction, but also its role in various disease settings and exercise capacity as well. Topics: 1. Overview of Mitochondrial Structure - Outer membrane and inner membrane with cristae - Mitochondrial matrix containing DNA, ribosomes, and enzymes - Inner membrane with electron transport chain complexes (I to IV) and ATP synthase 2. Functions of Electron Transport Chain Complexes - Complex I (NADH Dehydrogenase) transferring electrons from NADH to ubiquinone - Complex II (Succinate Dehydrogenase) transferring electrons from FADH2 to coenzyme Q - Complex III (Cytochrome bc1 Complex) passing electrons to cytochrome c and pumping protons - Complex IV (Cytochrome c Oxidase) transferring electrons to oxygen to form water and pumping protons 3. Role of Electron Transfer in ATP Synthesis - Proton pumping by complexes I, III, and IV creating an electrochemical gradient - ATP synthase utilizing proton gradient to synthesize ATP from ADP and Pi 4. Generation and Effects of Reactive Oxygen Species (ROS) - Formation of ROS as byproducts of ATP production - Types of ROS and their damaging effects on cellular components 5. Causes of ROS Production and Mitochondrial Dysfunction - Electron leak leading to premature electron reactions with oxygen - Factors contributing to increased ROS production such as environmental toxins and diet --- Leela Quantum Tech --- 6. Importance of Lipid Composition in Mitochondrial Membrane - Phospholipids, particularly cardiolipin, in the inner mitochondrial membrane - Role of cardiolipin in maintaining membrane integrity and supporting respiration proteins 7. Impact of ROS and Lipid Peroxidation on Mitochondrial Function - ROS-induced lipid peroxidation affecting cardiolipin composition - Implications of cardiolipin peroxidation in diseases like metabolic dysfunction and insulin resistance 8. SS-31 Peptide Intro - Accumulation in the inner mitochondrial membrane - Dimethyltyrosine residue scavenging oxyradicals and inhibiting lipid peroxidation 9. Mechanisms of Action of SS-31 Peptide - Stabilization of lipid constructs in the inner mitochondrial membrane - Prevention of mitochondrial permeability transition pore (mPTP) opening - Reduction of mitochondrial ROS and prevention of mitochondrial swelling and cell death 10. Applications and Research Areas of SS-31 Peptide - Studies in neuroinflammation, neurodegeneration, diabetes, age-related diseases, kidney disease, and cardiac function - Potential as a therapeutic agent for diseases associated with mitochondrial dysfunction 11. Conclusion - Overview of SS-31 peptide's mechanisms and potential applications - Reminder to always consult licensed medical professionals.
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Thanks again for tuning in!
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| 28 Jun 2024 | 127. Microplastics & Nanoplastics - How They Impact the Gut Microbiome, Liver Cells, & Mitochondria (Plus Several Keys for Reducing Microplastic Exposure) | 00:24:54 | |
In this episode, we explore the science behind microplastics (MPs) and nanoplastics (NPs), focusing on their effects on the liver and gut microbiome. We'll examine how these particles can disrupt cellular functions in hepatocytes, leading to oxidative stress and inflammation, and we will also discuss recent research findings related to MP exposure and gut dysbiosis. We will finish by addressing several strategies to reduce exposure. Topics: 1. Introduction - Introduction to microplastics (MPs) and nanoplastics (NPs) - Overview of their impact on the body, focusing on the liver and gut microbiome 2. Understanding Microplastics and Nanoplastics - Definition and differentiation of MPs and NPs - MPs: Plastic particles less than 5 millimeters (mm) in length - NPs: Subset of MPs, less than 1 micrometer (µm) in size - Sources of MPs and NPs - Primary MPs: Intentionally manufactured small particles (e.g., microbeads, nurdles, microfibers) - Secondary MPs: Degradation of larger plastic objects (e.g., cutting boards) 3. Chemical Composition of Microplastics - Overview of common polymers found in MPs - Polyethylene (PE), Polypropylene (PP), Polyethylene Terephthalate (PET), Polyvinyl Chloride (PVC), Polystyrene (PS), Polyurethane (PU), Nylon, Acrylic - Examples of products containing these polymers (e.g., bottled water, cutting boards, clothing) 4. Health Implications: Impact on Liver Cells - Cellular impact of MPs and NPs - Intracellular and extracellular presence - Specific polymers studied: PET, PE, PP - Mechanisms of cellular disruption - Disruption of mitochondrial membranes - Loss of membrane potential - Decreased ATP production and energy deprivation - Generation of reactive oxygen species (ROS) and oxidative stress - Activation of Kupffer cells and chronic inflammation - Concern for fatty liver disease and insulin resistance 5. Health Implications: Impact on Gut Microbiome - Overview of gut dysbiosis caused by MPs - Physical interaction with gut microorganisms - Chemical effects and associated additives - MPs as carriers for other pollutants or pathogens - Consequences of dysbiosis beyond the gut 6. Practical Tips to Reduce Exposure to MPs and NPs - Use reusable shopping bags - Use a water filter - Avoid single-use plastic products - Choose glass or stainless steel containers - Buy products with minimal plastic packaging - Opt for natural fiber clothing - Use biodegradable or eco-friendly cleaning products - Avoid personal care products with microbeads - Replace plastic kitchen utensils with wooden or metal alternatives - Choose bar soap instead of liquid soap - Avoid plastic cutting boards; opt for wood - Use alternatives to plastic wrap (e.g., beeswax wraps) Thank you to our episode sponsors: Hardy Nutritionals' Daily Essential Nutrients Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 09 Nov 2022 | 3. Brian Sanders, Food Lies Film, Eating Nose to Tail, Bioavailable Nutrients, and More | 00:47:09 | |
Welcome to the third episode of The Synthesis of Wellness podcast! Today, we have Brian Sanders on for a fantastic conversation covering so many great topics! Check out his company where you can purchase grass-fed, grass-finished meats, body care, and more: https://nosetotail.org AND check out his podcast: https://www.peak-human.com/about Topics: - Brian’s company “Nose to Tail” - Benefits of consuming nose to tail - Food waste - The 3 categories of beef: “grass-fed” vs. “grass-finished” vs. “regenerative” - When it comes to raising healthy cows, allowing them to choose their own food is imperative since they intuitively know what foods might supply the minerals they are deficient in - Dangers of conventional chicken and pork - The importance of consuming the “right” chicken and pork - All animal foods are healthy when eaten correctly - Food Lies Film and common food lies - Why anti-nutrients in plants shouldn’t be feared but should be taken into consideration - Ancestral proper food preparation can decrease anti-nutrients - The mighty lectin! - Gut problems caused by anti-nutrients - Why a purely plant-based diet might lead to overconsumption of food - Bioavailability of nutrients in plant vs. animal food - Why living like our ancestors is so beneficial - A little bit of Brian’s background and his filmmaking journey - The power of not being “polarized” when it comes to carbs vs. protein and fat - Brian’s biggest takeaways when it comes to common food misconceptions - The importance of a whole-foods diet - Brian’s #1 ancestral hack - Brian’s dietary preferences - Brian’s advice for a happier, healthier life Leave a rate and review! If you want to support the podcast, please go to the link in the bio. We greatly appreciate your help and support. | |||
| 11 Sep 2023 | 40. Vesugen Bioregulator Peptide (Peptides Episode) - Enhancing Blood Flow, Repairing Leaky Blood Vessels, Decreasing Edema & Hypoxia, & Even Supporting the Blood Brain Barrier | 00:33:52 | |
If you're looking to improve your circulation / blood flow and athletic performance or simply combat increased vascular permeability (which can create edema and, therefore, hypoxia) due to the damaging effects of hyperglycemia, inflammation, toxins, etc..., then this episode is a MUST-listen! We're delving into the intricacies of the vesugen bioregulator peptide – so stay tuned for some pretty intriguing research! Topics: 1. Introduction to the Episode - Previous background interest in vesugen: Lyme and Mold / CIRS issues - Introduction to bioregulator peptide vesugen - Effects on blood vessels, circulation, hypoxia, and athletic performance
2. Quick Overview of CIRS and the Circulatory System - Damage to the endothelial blood vessel wall due to high MMP-9 levels - Hemolysins released by MARCoNS - Narrowed capillaries and induced hypoxia - Interest in vesugen 3. Blood Cell Formation - Hematopoiesis - Process and origin in the bone marrow - Characteristics of multipotent hematopoietic stem cells (HSCs) - Regulation of HSC self-renewal vs. differentiation - Myeloid and Lymphoid Progenitors - Differentiated blood cells from each progenitor type - Pathway: Myeloid progenitor to erythrocyte - Role of Erythropoietin (EPO) 4. Maturation Process of Erythrocytes - Ejection of nucleus and organelles - Hemoglobin acquisition - Biconcave shape for optimal gas exchange - Transition to the bloodstream via sinusoids
5. Vascular Wall Anatomy and Dysfunction - Overview of vascular wall layers: Tunica intima, tunica media, and tunica externa - Detailed understanding of endothelial cell functions - Barrier function and vascular permeability - Vascular tone and blood flow regulation - Inflammation and the role in immune response - Angiogenesis and its significance 6. Bioregulator Peptide Vesugen - Definition and unique characteristics - Composition: Lysine, Glutamine, and Asparagine - Mechanism of action: Promotion of endothelial cell proliferation
7. Benefits and Potential of Vesugen - Restoration of endothelial function - Role in injury and endothelial dysfunction scenarios: edema, hypoxia, etc... - Protective effect on the blood-brain barrier - Impact on nitric oxide production and athletic performance, hair growth, skin health Thanks so much for tuning in! Pre-Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" and email thesynthesisofwellness@gmail.com a screenshot of the order confirmation to enter the GIVEAWAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 15 Apr 2024 | 113. Unique Superfoods and Adaptogens to Support Sleep and Enhance Energy, Traditional Chinese Medicine, and More (Feat. MoonBrew) | 01:01:21 | |
We are talking all things superfoods today with a focus on enhancing sleep quality and supporting sustained energy levels. Andrew and Allan are the Co-Founders of NoonBrew which is the first superfood tea designed for the afternoon slump. They wanted an alternative to coffee that didn’t keep you up at night and saw that no other beverage company was truly addressing the afternoon energy market. In 2021, they decided to make it themselves. Using Allan’s background in herbal medicine, they blended 19 superfoods for clean energy, calm focus, and digestion support. After selling to thousands of customers across the U.S., their team realized the importance of improved energy starting the night before with sleep. A year after formulating NoonBrew, they created the strongest magnesium sleep tea without melatonin, MoonBrew. In 2024, they are going all in on sleep with MoonBrew to continue helping people fall asleep, stay asleep, and wake up refreshed without the morning grogginess. Topics: 1. Introduction to MoonBrew - Evolution from NoonBrew to MoonBrew - Personal stories and motivation
2. Superfoods and Adaptogens Using TCM - Ashwagandha, Maca, L-Theanine - Ginger, Turmeric, Ginseng - Mushroom blend: Chaga, Cordyceps, Reishi, Lion’s Mane - Oolong Tea (polyphenols and antioxidants) 3. Ingredients in MoonBrew (and MoonBoost) and Their Data-Driven Sleep Benefits - Magnesium glycinate and Magnesium L-threonate (why?) - Herbs and their effects on neurotransmitters - Absence of melatonin - GABA - Glycine - Data and metrics: sleep trackers
4. Why Traditional Chinese Medicine? - Discussion on TCM's impact on ingredient formulation 5. How to Use MoonBrew and NoonBrew Effectively Check out NoonBrew and MoonBrew! Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 13 Oct 2023 | 54. Castor Oil Packs & Ricinoleic Acid - The Combined Effect of Enhanced Lymphocyte Activity & Improved Liver Enzymes + Notes on Supporting The Liver Through Biotoxin Illness | 00:30:37 | |
In this episode, I explore the science behind these castor oil packs and how ricinoleic acid, a key component of castor oil, enhances lymphocyte activity and improves liver enzymes. I also touch on their potential role in supporting the liver during biotoxin illness. It's a deep dive into the benefits of a simple yet potent natural remedy. Topics: 1. Introduction to Castor Oil Packs - CIRS / Biotoxin Illness - Brief overview of castor oil packs - Their accessibility and cost-effectiveness 2. The Basics of Castor Oil Packs - How to create and apply a castor oil pack - Materials needed for the process - Preparation steps and protecting the area 3. Transdermal Absorption and Circulation - Ricinoleic acid's properties for transdermal absorption - Vasodilation and the role of heat packs - How ricinoleic acid is transported in the bloodstream 4. Ricinoleic Acid's Effects on Liver Function - The liver's vascularization and blood supply - Interaction of ricinoleic acid with liver cells (hepatocytes) - Proposed mechanisms of ricinoleic acid on liver function 5. Research on Castor Oil Packs - Presentation of studies on the effects of castor oil packs - Impact on immune function and liver health - Discussion on proposed mechanisms vs. observed outcomes 6. Step-by-Step Guide for Using Castor Oil Packs - Materials required for creating and applying packs - Detailed steps for applying a castor oil pack - Frequency and timing recommendations - Importance of consulting a healthcare professional
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 22 Jan 2024 | 96. Dr. Jamie Kunkle - Strategies for Complicated Cases of Lyme (& Other Chronic Infections), Regulating the Mast Cells, & Restoring Immune Function (Plus a Dive into Peptides, Herbs, IVs, & More) | 00:55:15 | |
We are honored to have Dr. Jamie Kunkle ND on the podcast. With a diverse skill set encompassing Lyme and infectious diseases, autoimmunity, pain management, and more, Dr. Kunkle is a dual licensed Naturopathic Doctor and East Asian Medicine Practitioner (Acupuncturist). He has extensive experience in low dose immunotherapy, hyperbaric oxygen therapies, botanical medicine, and intravenous/intramuscular nutrition. Dr. Kunkle is also an active member of the International Lyme and Associated Diseases Society and holds degrees in neuroscience and Naturopathic Medicine from Bastyr University in Seattle, WA. His expertise is unmatched, in my opinion! Topics: Outline of Topics: 1. Toxins and Infections - Lyme disease - Mold exposure - Fungal and viral infections - Parasites 2. Interactions between Infections - Can one infection facilitate the development of another? - Mechanisms behind infection interactions: immune suppression + inflammation 3. Mast Cell Activation Syndrome (MCAS) and Infections - Why infections can induce MCAS - Mechanisms involved in the complex relationship - Considerations for detoxifying individuals with MCAS 4. Supportive Measures - Herbs, peptides, IVs, Ozone, Hyperbaric - Minimizing the risk of symptom exacerbation - Approaches and protocols 5. Balancing Infection and MCAS Management during Detox - Addressing infection-induced inflammation - Minimizing MCAS-related flare-ups - Striking a balance between infection and detox management
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 07 Jun 2024 | 123. Babesia (Lyme Co-infection) Part 2 - Anti-malarial Supplements, Proteolytic Enzymes to Break up Parasitic/Fibrin Nests, and Methylene Blue | 00:23:24 | |
In this part 2 episode, we dive into the pathology and symptoms of Babesiosis, exploring how the Babesia parasite infects red blood cells and evades the immune system. We discuss various labs and biomarkers to look out for. We then address various treatment protocols featuring anti-malarials including herbal supplements such as artemisinin and cryptolepis, and proteolytic enzymes like lumbrokinase and nattokinase. Additionally, we cover the use of methylene blue and its impact on Babesia parasites. Topics: 1. Introduction - Brief overview of Babesiosis and previous discussion - Overview of Babesia infection and its impact on red blood cells (RBCs) 2. Pathology of Babesiosis - Infection and multiplication within RBCs - Mechanisms of immune evasion - Expression of specific proteins on RBC surface - Adherence to capillary endothelial cells - Avoidance of spleen clearance - Antigenic variation and immune system evasion 3. Symptoms of Babesiosis - Air hunger - High fever - Severe fatigue - Muscle and joint pain - Persistent headaches - Jaundice - Dark urine - Organ failure (in severe cases) 4. Labs and Markers for Babesiosis - Hematological markers - Hemolytic anemia - Thrombocytopenia - Leukopenia - Hemoglobinuria - Hyperbilirubinemia - Elevated LDH levels - Reticulocytosis - Other markers - High C4a levels - Low CD57 count 5. Protocols - Importance of medical supervision and potential Herxheimer reaction - Overview of treatment approaches 6. Anti-Malarial Protocols for Babesiosis - Prescription Medications - Mepron (Atovaquone), Mechanism of action: inhibition of mitochondrial electron transport chain. - Azithromycin, Mechanism of action: blocking protein synthesis. - Herbal Approaches for Babesiosis - Artemisinin: Derived from sweet wormwood plant. Mechanism of action: production of reactive oxygen species (ROS). - Cryptolepis: Bioactive compound is Cryptolepine, Mechanism of action: disruption of DNA synthesis. 7. Proteolytic Enzymes - Lumbrokinase - Nattokinase 8. Methylene Blue - Synthetic dye - Mechanism of action: disrupting mitochondrial function and generating ROS within Babesia - Administration methods and effects 9. Conclusion - Recap of supplements and treatments discussed - Emphasis on individualized treatment plans, bioindividuality, and working with a medical physician
Thank you to our episode sponsor: Liver Medic Use code Chloe20 to save 20% on "Leaky Gut Repair" Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!
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| 03 Jan 2024 | 88. Dr. Petra Davelaar - Deutenomics & Over-Hydration, How Deuterium Slows Down Biochemical Reactions, Strategies to Reduce Dietary Deuterium & Increase Metabolic Water | 00:50:53 | |
We're thrilled to welcome Dr. Petra, a certified naturopathic doctor specializing in functional and Deutenomic medicine. Originally from the Netherlands and now practicing via telemedicine, she graduated from Bastyr University in California in 2016. Dr. Petra's passion lies in in-depth patient research and finding innovative ways to restore health. We're honored to have her on our podcast. Topics: 1. Understanding Deutenomics and Deuterium - Explanation of Deutenomics - Introduction to Deuterium - Variations in Deuterium Levels in Different Types of Water 2. Deuterium Accumulation and Mitochondrial Dysfunction - The Link Between Deuterium Accumulation and Mitochondrial Issues 3. Impact of Carbon-Deuterium Bond on Cellular Processes - Influence of Carbon-Deuterium Bond on Glycolysis - Effects on the TCA Cycle - Impact on Oxidative Phosphorylation 4. Consequences of Deuterium Accumulation - Discussing Potential Downstream Effects 5. Factors Leading to Deuterium Accumulation and Reduction Strategies - Causes of Deuterium Accumulation in the Body - Strategies for Decreasing Deuterium Accumulation 6. Hydration Strategies for Deuterium-Depleted Water - Approaches to Support the Creation of Deuterium-Depleted Water in Mitochondria Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 24 Jan 2025 | 161. Gastrointestinal Dysmotility | Motility in Intestinal Methanogen Overgrowth & Small Intestinal Bacterial Overgrowth, and a Brief Discussion of Low Stomach Acid, Hypochlorhydria | 00:18:13 | |
In this episode, we explore some of the neural and cellular mechanisms underlying gastrointestinal motility, emphasizing the roles of the enteric nervous system (ENS) and interstitial cells of Cajal (ICCs) in coordinating smooth muscle contractions throughout the digestive tract. We detail disruptions in motility seen in dysautonomia, intestinal methanogen overgrowth (IMO), and small intestinal bacterial overgrowth (SIBO). And, we finish with a brief discussion on the impacts of low stomach acid. Topics: 1. Introduction to Gastrointestinal Motility - Coordinated contractions of smooth muscle that move food, liquid, and waste through the gastrointestinal (GI) tract. - Neural, hormonal, and microbial factors. - Intestinal methanogen overgrowth (IMO) and small intestinal bacterial overgrowth (SIBO). 2. Neural Regulation of Gut Motility - The enteric nervous system (ENS) embedded in the walls of the GI tract. - The ENS, central nervous system (CNS), and vagus nerve. - The myenteric plexus governs motor control and peristalsis, while the submucosal plexus regulates secretion, absorption, and blood flow. - Stress and motility 3. Cellular Regulation of Gut Motility - Interstitial cells of Cajal (ICCs), pacemaker cells located near smooth muscle cells. - ICCs generate slow-wave electrical activity. - Acetylcholine enhances smooth muscle contraction. 4. Dysmotility and Potential Contributing Factors - Impaired ICC function, smooth muscle dysfunction, nervous system dysfunction. - Dysautonomia, a dysfunction of the autonomic nervous system. - External stressors, hormonal imbalances, and more. 5. Intestinal Methanogen Overgrowth (IMO) - Characterized by an overgrowth of methane-producing archaea in the intestines. - Excess methane production affects smooth muscle activity and can slow intestinal transit. - Symptoms such as bloating, abdominal discomfort, constipation. - Breath testing. 6. Small Intestinal Bacterial Overgrowth (SIBO) - Excessive bacterial colonization in the small intestine, disrupting normal gut function. - Protective mechanisms including stomach acid and intestinal motility. - Low stomach acid (hypochlorhydria) reduces the acidic environment needed to inhibit bacterial colonization. - Bloating, diarrhea/constipation, and more. 7. Overlap Between IMO and SIBO - Excess hydrogen produced in SIBO can serve as a substrate for methane production in IMO. - Can exacerbate each other, creating a loop that worsens symptoms. 8. Addressing Dysmotility and Overgrowth - Determining the root cause of dysmotility. - Dysmotility can involve multiple regions of the GI tract. Thank you to our episode sponsors: 1. Shop Fresh Press Farms' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. 2. Check out Ulyana Organics' Tallow Wild Yam Cream and Healing Facial Oil, and use code CHLOE10 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 29 Nov 2024 | 153. The Role of the Intestinal Microbiome in Modulating HPA Axis Activity | Intestinal Barrier Function, Cortisol, Testing, & More | 00:17:40 | |
In this episode, we dive into the interplay between the hypothalamic-pituitary-adrenal (HPA) axis and the microbiota-gut-brain (MGB) axis, highlighting their bidirectional communication through endocrine, immune, and neural pathways. We’ll explore how gut-derived metabolites like short-chain fatty acids (SCFAs) and endotoxins like LPS influence HPA axis activity; conversely, we explore how dysregulated cortisol can impact gut barrier function, immune signaling, and more. We also discuss testing including stool analysis and DUTCH tests. Topics:
Thanks for tuning in! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter
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| 12 Jan 2024 | 92. Upgrading the Mitochondria for Enhanced Energy & Productivity in the New Year - 4 MAJOR Supplements, Critical Lifestyle Habits, Treatments, & Combatting FATIGUE | 00:31:47 | |
Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function. Topics: 1. Introduction to Mitochondrial Dysfunction and Energy Production - Overview of optimizing natural energy levels - Factors leading to mitochondrial dysfunction and FATIGUE 2. Understanding Mitochondrial Structures - Outer membrane - Permeability and function - Intermembrane space - Role in proton gradient - Inner membrane - Cristae and its significance - Matrix - Krebs cycle and NADH generation - Mitochondrial DNA and ribosomes 3. Mechanisms of Mitochondrial Dysfunction - Loss of inner mitochondrial membrane potential - Alterations in the electron transport chain - Reduced transport of critical metabolites 4. Ways to Improve Mitochondrial Function - Preface for non-root cause issues - Factors causing mitochondrial damage - Example of ROS impact on ATP production 5. Supplements for Enhancing Mitochondrial Function - Alpha lipoic acid - Role in increasing glutathione levels - L-carnitine - Fatty acid transport and mitochondrial function - Use in weight loss - CoQ10 - Involvement in the electron transport chain - Mitochondrial membrane phospholipids - Lipid replacement therapy for repairing damage already done 6. Essential Minerals and Micronutrient Blood Panel - Importance of essential minerals in mitochondrial metabolism - The need for micronutrient blood panel 7. NAD+ and NADH - Importance in the electron transport chain - Precursors like NMN and NR for optimization 8. Other Modalities for Mitochondrial Support - Mention of red light therapy - Emphasis on dietary choices and antioxidant intake - Importance of structural repair with lipid replacement therapy 9. Additional Tools and Research - Urolithin A for stimulating mitochondrial recycling process
Thanks for tuning in! Book An Intro Coaching Call with Chloe Porter Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 06 Sep 2024 | 139. Neuroanatomy of Sleep | Understanding the Suprachiasmatic Nucleus Plus Key Hormones & Neurotransmitters; Supplementation; Chronic Inflammation & Underlying Root Causes Contributing to Poor Sleep | 00:19:59 | |
In this episode, we explore the neuroanatomical and molecular mechanisms underlying sleep regulation, focusing on the interplay between the suprachiasmatic nucleus, brain stem, and pineal gland in maintaining circadian rhythms. We dive into the biochemical pathways involving neurotransmitters such as GABA and hormones like melatonin, elucidating their synthesis and role in sleep-wake transitions. Further, the discussion extends to practical strategies, emphasizing the influence of light exposure on melatonin production and the potential benefits of specific amino acid supplementation in supporting sleep quality. Additionally, we address the impact of chronic inflammation and other root causes of sleep disturbances, exploring how systemic health issues can disrupt sleep. Topics: 1. Introduction to Sleep Neuroanatomy - Overview of key brain structures involved in sleep regulation - Emphasis on the hypothalamus, brain stem, thalamus, basal forebrain, and pineal gland
2. Deep Dive into Key Brain Structures - Hypothalamus - Detailed role of the suprachiasmatic nucleus (SCN) in circadian rhythm regulation - Connection between SCN, light perception, and neuronal control - Brain Stem - Description of sleep-wake transitions mediated by the midbrain, pons, and medulla - Mechanisms of GABA production and its impact on inhibitory neurotransmission - Thalamus - Functions as a sensory relay - Pineal Gland - Regulation of melatonin synthesis, influenced by light exposure and SCN signaling - Basal Forebrain - Neuronal mechanisms promoting alertness and facilitating sleep onset - Role of adenosine accumulation in sleep pressure and its neurochemical effects 3. Mechanisms of Sleep Regulation - Exploration of the circadian rhythm's molecular underpinnings involving CLOCK and BMAL1 genes - Feedback loops involving period and cryptochrome proteins, detailing their synthesis and degradation within the SCN - Hormonal regulation by the SCN through cortisol and melatonin 4. Strategies to Support Sleep Quality - Importance of synchronizing light exposure with natural environmental cycles - Supplementation strategies based on literature: - GABA and L-theanine supplementation supporting inhibitory signaling - L-tryptophan may support serotonin and melatonin synthesis 5. Addressing Underlying Root Causes and Sources of Chronic Inflammation Contributing to Poor Sleep - Role of neuroinflammation and gut dysbiosis in sleep disruption - Discussion on neurotransmitters synthesized in the gut - Hormonal impacts
Thank you to our episode sponsor: 1. Check out Liver Medic and use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 12 Jul 2024 | 130. Mast Cell Activation Syndrome - Discussing How Pathogenic Microbes Can Activate Mast Cells & Addressing Histamine-Producing and Histamine-Degrading Probiotics | 00:23:11 | |
In this episode, we explore the role of probiotics in managing histamine levels and mast cell activation syndrome (MCAS), particularly in the context of rebuilding the gut microbiome. We discuss which probiotic strains could contribute to symptoms (in the short term) due to their histamine-producing properties, such as Lactobacillus casei and Lactobacillus reuteri, and we highlight beneficial strains that degrade histamine, including Lactobacillus plantarum. Topics: 1. Introduction to Histamine and Mast Cell Activation - Overview of histamine and mast cell activation syndrome (MCAS) - Understanding histamine production 2. Breakdown of White Blood Cells (WBCs) - Origin of WBCs from hematopoietic stem cells in the bone marrow - Categories of WBCs: granulocytes, monocytes, and lymphocytes 3. Examination of Granulocytes - Neutrophils: Role in bacterial infections - Eosinophils: Role in allergic reactions and parasitic infections - Basophils: Involvement in inflammatory and allergic responses through histamine release - Mast Cells: Similarities to basophils, maturation in tissues, and histamine release 4. Examination of Agranulocytes - Monocytes: Phagocytic function and differentiation into macrophages and dendritic cells - Lymphocytes: - T cells: Subtypes and their functions (helper T cells, cytotoxic T cells, regulatory T cells) - B cells: Antibody-mediated immunity - NK cells 5. Mast Cells vs. Basophils - Location and function comparison - Importance in histamine production 6. Mast Cell Activation Syndrome (MCAS) - Triggers of MCAS (infections, environmental exposures, dietary factors, genetic predispositions) - Focus on addressing root causes (lyme?, mold?, candida?, SIBO?, ...) 7. Probiotic Use in the Context of MCAS - Probiotics and pathogenic microbes in the context of mast cell activation 8. Example: Candida and Mast Cell Interaction - Recognition of Candida by mast cells through pattern recognition receptors (PRRs) - Activation pathways and release of histamine and other inflammatory mediators 9. Probiotics and Histamine Production - Probiotic strains that produce histamine - Lactobacillus casei, - Lactobacillus reuteri, - Lactobacillus bulgaricus... - Probiotic strains that do not produce histamine and/or degrade histamine - Bifidobacterium infantis, - Bifidobacterium longum, - Bifidobacterium bifidum, - Bifidobacterium breve, - Lactobacillus plantarum, - Lactobacillus rhamnosus, - Lactobacillus gasseri, - Lactobacillus salivarius
Thank you to our episode sponsors: Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Use code CHLOE15 to get 15% off Tremetes' Turkey Tail Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 27 Feb 2023 | 8. Danielle Hamilton - Blood Sugar, Insulin Resistance, and The Importance of Self-Love | 01:01:02 | |
Welcome to the 7th episode of The Synthesis of Wellness podcast! Today, we have Danielle Hamilton, a nutritional therapy practitioner and blood sugar specialist. She has an amazing backstory and journey in overcoming PCOS and discovering that blood sugar was at the root of her hormonal imbalance. Now, her goal is to help sugar cravers regain their energy, lose weight & balance their hormones without starving themselves or spending hours in the gym. Danielle is not only super smart, but she is one of the most genuine individuals I’ve ever spoken with! I know you’ll enjoy this one! Topics: - What is blood sugar? - What range should our blood sugar be within before and after meals? - How the blood sugar rollercoaster leads to chronic hunger and anxiety - What happens when insulin builds up too much? - How does insulin resistance develop and why is it so important? - Snacking does not keep your “metabolism firing,” instead, it can lead to a constant outpouring of insulin in your body - How you can use a CGM – continuous glucose monitor - The 2-hour rule - How inflammation and stress impact blood sugar - How inflammation might disrupt cell receptors and create insulin resistance at the cellular level - What are seed oils and why are they important? - Troubleshooting high blood sugar… - Importance of chewing your food well, resting while eating, and calming the nervous system - Danielle’s advice and daily habits | |||
| 22 Mar 2024 | 109. Methylene Blue - Oxygen Delivery & Utilization, Mitochondrial Hacking, Antimicrobial Benefits, & The Effect on The Gut Microbiome (+ My Thoughts on Supplementation) | 00:30:57 | |
We uncover the various capabilities of methylene blue, particularly its pivotal roles in enhancing mitochondrial function, optimizing energy production, and facilitating oxygen delivery. We also dive into the question of whether its antimicrobial properties impact the gut microbiome in a positive or negative way. Lastly, we explore the downstream effects of improved mitochondrial function, including cognitive and mood enhancement and potential anti-aging benefits. Topics:
Thank you to our episode sponsors: Veri CGM (use code: VSM-THESYNTHESISOFWELLNESS)
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 29 Sep 2023 | 48. Mouth Tape & The Effect of Nasal Breathing on Nitric Oxide Flow, Brain Cognition, & Oral Health. Plus Using Nasal Saline Rinses to Decrease Dark Eye Circles & Enhance Facial Lymphatic Drainage | 00:37:40 | |
Today, we are diving into the science behind mouth tape. We examine the biological effects of mouth breathing versus nasal breathing, and we finish the conversation with some important considerations to keep in mind. Then, we address how saline nasal irrigations or rinses can actually stimulate lymphatic drainage in the face, decrease inflammatory mediators, and consequently decrease under-eye, dark circles. Stay tuned for this one! It is a good one for sure! Topics: 1. Introduction to Mouth Tape - Definition and popularity of mouth tape. - The purpose: promoting optimal breathing patterns during sleep. 2. Nasal Breathing vs. Mouth Breathing - Natural preference for nasal breathing. - Benefits: air is heated, humidified, and filtered. - Consequences of not filtering, humidifying, and warming inhaled air. - Comparison of air flow resistance during daytime and nighttime. - Explanation of how mouth breathing narrows the upper airway during sleep. - Effects on retropalatal and retroglossal areas. - Risks associated with mouth breathing: Potential hypoxia. Brain functional problems and lower oxygen saturation. Oral health concerns. 3. Effects on Oral Health from Mouth Breathing - Dry mouth environment. - Reduced saliva flow. - Risk of dental cavities. - Gum disease. - Bad breath. - Dental hypersensitivity. - Influence on the development of facial bones and teeth position. 4. The Importance of Nitric Oxide - Production site: paranasal sinuses. - Accumulation in nasal passages. - Role in vasodilation and its significance in breathing practices. 5. Benefits of Mouth Tape for Nasal Breathing - Transition from traditional tapes to specialized products. - Application and effects during sleep. - Criteria for selecting the right mouth tape: - Material and hypoallergenic properties. - Residue, ease of removal, and moisture resistance. - Breathability for skin comfort. 6. Introduction to Saline Nasal Rinses - Personal anecdote on why saline nasal rinses were started. - Benefits observed: clearer sinuses and reduced facial puffiness. - Historical context and origins. 7. Benefits and Mechanisms of Nasal Irrigation - Mechanical flushing of nasal passages. - Removal of allergens, bacteria, viruses, and irritants. - Reduction in inflammatory mediators. - Impact on cilia beat frequency (CBF). - Role of cilia in respiratory passages. - Benefits of isotonic saline rinse for cilia function. 8. Holistic Benefits of Nasal Rinses - Support for lymphatic drainage in the face. - Reduction in dark under-eye circles. - Close proximity with sinus passages. - Causes: inflammatory mediators and pressure on blood vessels. 9. Best Practices and Precautions with Saline Nasal Rinses - Importance of using sterile, distilled, or boiled water. - Cleanliness of the irrigation device. - Different types of devices available. Thanks so much for tuning in! Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 28 Feb 2025 | 167. The Gut-Immune Axis | Gastrointestinal Mucus & Lactoferrin, Lactoferrin Levels, a Brief Discussion on Candida Overgrowth, & More | 00:16:09 | |
In this episode, we detail the gut-immune axis, focusing on the protective mucus layer, antimicrobial peptides, and the role of lactoferrin in intestinal health. We discuss endogenous secretions and how lactoferrin functions as an antimicrobial, immunomodulatory, and iron-regulating glycoprotein, influencing microbial balance and intestinal barrier integrity. Additionally, we highlight lactoferrin testing and levels. We finish by going through supplementation as a phenomenal tool. Topics: 1. The Intestinal Barrier & Mucus Layer - The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria. - The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA). - Intestinal epithelial cells including goblet cells and enterocytes. 2. Immune Cells in the Gut - The lamina propria. - Macrophages, dendritic cells, neutrophils, B cells, T cells, mast cells, and more. 3. Antimicrobial Peptides & Secretory IgA - AMPs and sIgA in the mucus layer regulate microbial balance and prevent pathogen adhesion. 4. Lactoferrin: Functions & Sources - Iron-binding glycoprotein, antimicrobial and immunomodulatory properties. - Found in mucosal secretions, colostrum, and more. - Intestinal epithelial cells (IECs) and neutrophils. 5. Lactoferrin’s Role in Intestinal Health - Regulates iron absorption via lactoferrin receptors (LFR)on enterocytes. - Sequesters free iron, limiting bacterial growth, bacteriostatic. - Destabilizes bacterial membranes, cell lysis, bactericidal. 6. Lactoferrin Levels - Neutrophils release lactoferrin during infection,increasing its presence in the large intestine. - Fecal lactoferrin levels. - Fecal calprotectin levels. 7. Lactoferrin & Candida Overgrowth - Fungal membranes. - Aiding in the inhibition of biofilm formation. 8. Lactoferrin Supplementation & Benefits - Supports gut microbiota, epithelial integrity, and immunemodulation. - Bovine colostrum and as a supplement. 9. Conclusion - The intestinal mucus layer is key to gut barrier function. - Lactoferrin plays a central role in microbial regulationand immune defense. Thank you to our episode sponsors: 1. Shop Fresh Press Farms'Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. 2. Shop CYLN's full skincare line here. Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness | |||
| 05 Jun 2023 | 13. Biohacking Emotions by Leveraging Neurotransmitters & Inflammation | 00:27:21 | |
Welcome to the 13th episode of The Synthesis of Wellness Podcast! Today is all about biohacking emotions using techniques to optimize neurotransmitters and strategies to decrease neuroinflammation. As always, these are my personal tips, practices, and techniques. Everyone is so bio-individual, so always work with a physician and do your own research so that you can find what works best for your body, in particular. Thanks so much for tuning in! Topics: - My experience & research-driven tips/hacks for increasing dopamine, serotonin, endorphins, and oxytocin - My experience & research-driven tips/hacks for decreasing neuroinflammation - Neuroinflammation & its connection to poor mental health Resources: Go to the shop page on synthesisofwellness.com and use code CHLOEP for 30% off Silver Biotics' products! | |||
| 16 Oct 2023 | 55. Dr. Paul Barattiero - How Hydrogen Water (Hydrogen Gas Specifically) Can Heal the Gut, Decrease Inflammation, & Support Our Body's Innate Healing Abilities | 00:52:09 | |
We are honored to be joined by Dr. Paul Barattiero! Dr. Paul Barattiero, a seasoned lecturer with over two decades of global experience, dedicated the past 14 years to advocating the extraordinary benefits of hydrogen gas within the body. Recognizing its potential to combat oxidative stress and inflammation, key contributors to disease, he delved into research, amassing over 1250 studies supporting hydrogen gas therapy across 200 disease models. Dr. Paul's work led to the creation of the Echo Hydrogen Water® System, and he has shared his insights on television in the USA, Germany, and Switzerland. Topics: 1. Introduction to Hydrogen Water - Composition and differences from regular water 2. General Benefits of Hydrogen Water - Overview of benefits: antioxidant, anti-inflammatory 3. Production and Methods - Hydrogen water production methods - Hydrogen tablets vs. water - Shelf life 4. Hydrogen Water and Gut Health - Interaction with the gut: electric potential - Potential benefits for gut issues 5. Detoxification Support - Role in detox processes - Organs/systems supported in detox 6. Hydrogen Water in Biotoxin Illness - Role in addressing biotoxin-related illnesses - Impact on inflammation reduction, gut support, and detox in this context
Thanks so much for tuning in! Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 01 Mar 2024 | 105. SS-31 Peptide and Other Supplements in the Context of Mitochondrial Dysfunction, The Mitophagy Stack More Powerful Than Urolithin A Alone, How Mitochondrial Dysfunction Creates Chronic Fatigue | 00:27:10 | |
In this episode, we explore the research behind SS-31 peptide and other supplements as possible groundbreaking interventions for mitochondrial dysfunction, shedding light on their mechanisms as detailed in the scientific literature. We delve into the concept of the mitophagy stack, presenting it as a superior alternative to "Urolithin a" alone, for enhancing the clearance of damaged mitochondria and rejuvenating cellular energy production. Furthermore, we unravel the complex relationship between mitochondrial dysfunction and chronic fatigue, elucidating how impaired energy production at the cellular level can lead to pervasive fatigue and compromised quality of life. Topics:
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 03 May 2024 | 117. (Lyme & Mold Part 2) Biotoxin Illness Binders - Bile Acid Sequestering, Bile Flow Support, When to Take Binders, Chemical Charges of Various Binders, & More. | 00:26:14 | |
In this episode, we undertake a detailed examination of the diverse mechanisms of action underlying various binders employed in detoxification protocols, with a particular focus on their application in biotoxin illnesses such as Lyme disease. We dissect the differential efficacy of bile acid sequestrants like cholestyramine versus natural binders such as activated charcoal and zeolite, elucidating their distinct modes of action in toxin adsorption and excretion pathways. Moreover, we elucidate the intricate interplay between chemical charges of binders and biotoxins like lipopolysaccharides (LPS), shedding light on the complexities of binder selection for optimal detoxification outcomes. Topics: 1. Introduction to Binders - Definition of binders - Purpose in detoxification - Application in Lyme disease treatment 2. Mechanisms of Action - Bile Acid Sequestrants vs. Natural Binders - Bile Acid Sequestrants: - Function of cholestyramine - Interaction with bile acids - Impact on toxin excretion - Natural Binders: - Adsorption mechanism - Broad-spectrum binding capacity 3. Chemical Charge Considerations - Impact of charge on binding efficacy - Interaction with biotoxins like lipopolysaccharides (LPS) which are negatively charged - Paper published showing how activated charcoal (-) can help bind LPS (-), indicating that charge doesn't totally eliminate its binding ability 4. Selection of Binders - Bile Acid Sequestrants: - Cholestyramine - Okra powder (Beets, Carrots...) - Natural Binders: - Activated Charcoal - Bentonite Clay - Zeolite - Chlorella - Cilantro - Pectin - Importance of using a spectrum of binders 5. Timing and Compatibility - Considerations for simultaneous use of different binders - Importance of timing in binder intake 6. Supporting Detoxification Process - Promotion of bile flow: ox bile + bitters - Support for liver detoxification - Supplements for liver support 7. Conclusion and Recap - Summary of binder types and their roles - Importance of binders in biotoxin illness treatment - Recognition of compromised immune system's role in toxin clearance (HLA genes)
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 27 Dec 2023 | 85. Dr. Daved Rosensweet - Bio-Identical Hormones, Menopause, Muscle Loss, & Birth Control | 00:53:48 | |
We're honored to have Dr. Daved Rosensweet on the podcast. With a medical degree from the University of Michigan in 1968, he's been in private practice since 1971, spanning multiple states. Dr. Rosensweet notably led the first Nurse Practitioner training program in the U.S. and played a key role in health promotion for New Mexico. He also educates health professionals on bio-identical hormone treatments for menopausal women. Topics:
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 02 Aug 2024 | 133. HLA Gene Variants & Their Impact on the Immune Response: Specific Gene Variants Associated with Chronic Lyme & Other Conditions, HLA Gene Testing, & More | 00:22:00 | |
In this episode, we dive into the critical role of HLA gene variants, such as HLA-DRB1, and their profound impact on immune system function, particularly focusing on their significance in conditions like Lyme disease and mold toxicity. We'll explore how variations in these HLA genes, like the HLA-DRB1*0401 allele, influence the body's ability to recognize and respond to pathogens, potentially leading to chronic symptoms. The discussion will also cover HLA gene variant testing and how it can lend insight when it comes to taking a bioindividual approach to supporting the immune system. Topics: 1. Introduction - Explanation of HLA gene variants - Importance of HLA genes in immune system function 2. Basics of Genetics and Immunology - What is a chromosome? - Introduction to genes and their functions - Overview of DNA and protein synthesis 3. Major Histocompatibility Complex (MHC) - Description of the Major Histocompatibility Complex - Division of MHC genes into Class I, II, and III - Role of Class I MHC genes in antigen presentation - Role of Class II MHC genes in antigen presentation - Function of Class III MHC genes 4. HLA Genes and Immune Function - Explanation of Human Leukocyte Antigen (HLA) genes - Connection between MHC genes and HLA genes (human MHC) - Transcription and regulation of HLA genes - Response to internal and external signals - Role of Antigen-presenting cells (APCs) 5. Pathogen Recognition and Immune Activation - Mechanism of pathogen recognition by HLA genes - Activation of immune response by antigen presentation - Formation and function of peptide-HLA complexes 6. Impact of HLA Variants on Disease - Specific focus on Lyme disease and mold toxicity - Role of HLA Class II alleles in immune response - Association of HLA-DR alleles with chronic Lyme disease - Sensitivity to mold exposure linked to certain HLA gene variants 7. Testing and Implications of HLA Gene Variants - Importance of HLA gene variant testing - Broader implications for diseases like lupus and multiple sclerosis - Personalized approaches based on HLA gene variants 8. Biotoxin Illness and Poor Antigen Presentation Due to an HLA Gene Variant - Strategies to support immune system function in the presence of biotoxins - Importance of detoxification pathways and binders
Thank you to our episode sponsor: Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 14 Jun 2024 | 124. Methylation - MTHFR Gene Variants, Under-Methylation and its Impact on Mold or Lyme (& Detoxification in General), Helpful forms of Vitamin B9, & More | 00:26:29 | |
In this episode, we dive into the critical process of methylation and its significance in detoxification, mood regulation, and overall cellular function. We explain the step-by-step conversion of dietary folate to its active form and how gene mutations can impair this process, leading to reduced SAMe levels, high homocysteine, and various health issues. Finally, we discuss practical strategies to support methylation through dietary choices and targeted supplementation. Topics: 1. Introduction - Overview of previous discussions on Lyme and its coinfections (Babesia and Bartonella) - Transition to the importance of supporting detoxification pathways 2. The Role of Methylation in Health - Definition and significance of methylation - Importance in detoxification, mood, energy, and gene activation 3. Methylation Process - Biochemical explanation of methylation - Key molecules involved: S-adenosylmethionine (SAMe), methionine, ATP - Dietary sources and conversion process of folate (vitamin B9) 4. Synthesis of S-adenosylmethionine (SAMe) - Step-by-step process from dietary folate to SAMe - Enzymatic conversions: DHFR, MTHFR - Role of active folate (L-5-MTHF) in methylation 5. Gene Mutations and Their Impact - Common MTHFR gene mutations: C677T and A1298C - Effects of reduced MTHFR enzyme activity - Consequences: elevated homocysteine levels, reduced SAMe production 6. Consequences of Impaired Methylation - DNA methylation and gene expression - Neurotransmitter synthesis and mental health - Detoxification efficiency - Accumulation of unmetabolized folic acid 7. Supporting Methylation - Dietary strategies: - Emphasizing natural folate intake - Food sources: leafy greens, legumes, fruits - Supplementation strategies: - Ensuring adequate intake of vitamin B12 and B6 - Using L-5-MTHF instead of synthetic folic acid - Trimethylglycine (TMG) supplementation Thank you to our episode sponsor: GenuinePurity Use code CHLOE20 to get $20 off GenuinePurity Trans-Resveratrol Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!
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| 06 Nov 2023 | 64. David Milburn - CTO of Hypoallergenic Air - How to Clean the Air You Breathe (Mold, Chemicals, Particulate, Viruses, Bacteria, & More) + Portable Technologies to Use While Traveling | 01:01:40 | |
We're honored to have David Milburn on the podcast today! He's the CTO at Hypoallergenic Air LLC. With well over a decade of experience at HypoAir, David has been at the forefront of solving complex air quality issues for various clients, from aerospace manufacturing facilities to COVID-19-impacted hospitals in Brooklyn. Over the years, he has helped numerous individuals and businesses tackle their unique air quality challenges. Topics: 1. Prioritizing Indoor Air Quality - Environmental Concerns and Indoor Air - Health Implications of Poor Indoor Air Quality - The Importance of Air Quality in Homes and Workplaces 2. Understanding Harmful Air Contaminants - Common Indoor Air Pollutants - Health Risks Associated with Contaminants - Sources of Indoor Air Pollution 3. The Significance of PM2.5 - Definition and Characteristics of PM2.5 - Health Effects of PM2.5 Exposure - Monitoring and Measurement of PM2.5 Levels 4. HEPA Filtration - What Is a HEPA Filter? - How HEPA Filters Work - HEPA Filters and Air Purification Devices 5. Activated Carbon in Air Purification - Role of Activated Carbon in Filtration - Adsorption of Gases and Odors - Effectiveness for Removing Specific Contaminants 6. Photocatalytic Oxidation (PCO) Technology - NASA's Contribution to Air Quality - Principles of PCO Technology - Application of PCO in Indoor Settings 7. Advancements with AHPCO Nanotechnology - Introduction to AHPCO Nanotechnology - Enhancements Over Traditional PCO - Scenarios for AHPCO Implementation 8. Polarizing Technology - Mechanism of Polarizing Technology - Unique Advantages in Air Quality Improvement - Suitable Situations for Polarizing Technology 9. Practical Approaches to Improving Air Quality - Improving Air Quality with HVAC Systems: - Tips and strategies for optimizing indoor air quality using existing HVAC systems. - The role of high-quality filters and regular maintenance. - Enhancing Air Quality with Plug-In Devices: - Exploring effective plug-in air purifiers and their placement for maximum impact. - The advantages of portable air quality monitors for real-time feedback. 10. Air Quality Beyond Home and Office - Traveling and Airplane Air: - Air quality considerations when traveling by air. - Tips for maintaining personal air quality during flights. - Hotel Air Quality: - Hypoallergenic hotel rooms. - Using portable air purifiers and travel-friendly devices.
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 04 Oct 2024 | 144. The Roles of the Vagus Nerve and Enteric Nervous System in Digestion and Intestinal Motility | Links to Small Intestinal Bacterial Overgrowth (SIBO) | 00:18:42 | |
In this episode, we explore the critical roles of the enteric nervous system (ENS) and the vagus nerve in digestion and gut motility. We also examine how autonomic nervous system dysfunction can contribute to conditions such as Small Intestinal Bacterial Overgrowth (SIBO). Topics: 1. Introduction to the Nervous System and Its Role in Digestion - Overview of the enteric nervous system (ENS) and vagus nerve - Focus on location, function, and associated dysfunctions 2. Overview of the Enteric Nervous System (ENS) - ENS as one of the three divisions (Sympathetic, Parasympathetic, Enteric) - Location and function overview 3. The Mucosa - Structure and Function of the Mucosa - Epithelium (cells such as enterocytes, goblet cells, enteroendocrine cells) - Lamina propria (loose connective tissue, immune cells) - Smooth muscle layer 4. The Submucosa - Structure and Function of the Submucosa - Thicker connective tissue providing support for blood vessels, lymphatics, and nerves 5. The Submucosal Plexus (Part of the ENS) - Location and Functions of the Submucosal Plexus - Regulation of digestive enzyme secretion, mucin production, and electrolyte balance - Role in creating protective mucus barriers and controlling local blood flow 6. Mucus Secretion and Protection - Role of Goblet Cells - Secretion of mucins and formation of the protective mucus layer 7. Blood Flow Regulation by the Submucosal Plexus - Role in adjusting blood supply during digestion 8. Neuronal Cells of the Submucosal Plexus - Sensory Neurons: Detecting changes in the gut - Interneurons: Processing and integrating sensory input - Secretomotor Neurons 9. Communication Between Neurons and Epithelial Cells - Chemical Signaling and Neurotransmitters - ACh and Vasoactive Intestinal Peptide (VIP) - Serotonin's role in activating sensory neurons and regulating secretion 10. Role of the Vagus Nerve in Digestive Regulation - Vagus Nerve as Part of the ANS - Regulation of digestive secretions, gut motility, and smooth muscle contractions 11. Small Intestinal Bacterial Overgrowth (SIBO) - Connection Between Autonomic Nervous System Dysfunction and SIBO - Reduced motility leading to bacterial overgrowth - Impact on gut environment - Root cause approach
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 06 Sep 2023 | 38. Dr. Zulia Frost - Mitochondrial Optimization Using Red & Near Infrared Light, EZ Water, Collagen Production & Lymph Flow, Plus a Discussion on The Fascinating Properties of Other Light Wavelengths | 00:52:33 | |
Today, we are honored to welcome Dr. Zulia Frost to the podcast! Zulia, a prominent clinician globally recognized, specializes in neuromodulation, bio-resonance, and photobiomodulation therapies. Holding a Doctorate in General Medicine and Pediatrics, along with advanced training in ultrasonic diagnostics, radiology, Traditional Chinese Medicine (TCM), and Acupuncture, she is a leading figure in the field. Having studied photo-biomodulation therapy at Weber Institute, Germany, Zulia has gained three decades of experience and has aided numerous patients in achieving pain relief and improved function through advanced laser techniques, including non-invasive 'acupuncture'. Co-founding 'Recharge' and currently serving as the clinical director, Zulia aspires to make photobiomodulation a household standard, focusing on the promotion of Red Light Therapy through the innovative FlexBEAM device, thus contributing to enhanced well-being and a healthier lifestyle for all. I LOVE her and her mission! Topics: 1. Introduction to Photobiomodulation 2. Mechanism of Action: Red and Near Infrared Light - How red and near infrared light work - Differences between red and near infrared wavelengths 3. Effects on Mitochondria - Mitochondrial response to light exposure - Role of cytochrome c oxidase - Exclusion zone water and mitochondrial membrane potential - Increased ATP production 4. Absorption of Light by Other Cells - Absorption of different light wavelengths (blue, green, yellow, etc.) 5. Other Effects of Red / Near Infrared Light - Enhancement of blood flow (nitric oxide): Aids in injury Recovery - Influence on lymph flow - Effects on collagen - Fascinating effects on melatonin production (+ experiment analyzing melatonin production even when eyes are covered) 6. Considerations for Light Device Selection - Specifications of red and near infrared light devices 7. Depth of light penetration - Impact of wavelength and power density on penetration depth 8. FlexBEAM device: USE CODE "chloeporter" for $60 OFF a FlexBEAM device! Thanks so much for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 06 Jun 2023 | 14. Silver Biotics - SilverSol Technology & A Deep Dive into the Science | 00:55:18 | |
Welcome to the 14th episode of The Synthesis of Wellness Podcast! Today is all about silver, and we've got Silver Biotics here to tells us more about their SilverSol Technology. Thanks for tuning in! Topics: - Welcome Steve! - History of silver - Common misconceptions about silver - Ionic vs. colloidal silver - Why does ppm matter? - What happens to the good microbes? - What happens on the cellular level when silver encounters an invader? - A review of anti-microbial properties - Products: immune support, pet care, wound care, cosmetics - What should the consumer be on the lookout for when purchasing high-quality silver products? Loved Steve from Silver Biotics on the show, and we hope you did too! Resources: Go to the shop page on synthesisofwellness.com and use code CHLOEP for 30% off Silver Biotics' products! You can also check out more at silverbiotics.com or follow them on Instagram @Silverbiotics | |||
| 16 Aug 2023 | 29. NAD+, Its Use in Energy Metabolism, Factors That Deplete NAD+ (Including Aging), 6 Strategies to Increase NAD+ Levels, & Thoughts on Using NAD+ Therapies for Mold Illness | 00:40:07 | |
In today's episode, we are diving into NAD+ and exploring how it is a critical component for breaking down fuel, such as glucose, and ultimately converting that fuel to ATP. We will explore various factors that deplete NAD+ or decrease the NAD+/NADH ratio as well as 6 proven strategies to increase NAD+ within the body. Lastly, we wrap up the episode with a conversation pertaining to the use of NAD+ therapy for CIRS/Biotoxin illness, specifically Mold Illness. Thanks so much for tuning it! Topics: 1. Understanding NAD+ and Its Role - Definition of NAD+ and NADH - Explanation of coenzymes in chemical reactions - NAD+ and NADH as coenzymes for electron transfer - Role in glucose metabolism and energy production - Importance of NAD+ for various cellular functions 2. Glycolysis and NAD+ - Illustration of glucose metabolism and insulin release - Role of GLUT4 transporters in glucose entry into cells - Introduction to glycolysis and its steps - Role of NAD+ as a coenzyme in glycolysis - Generation of NADH during glycolysis 3. TCA (Krebs) Cycle and NAD+ - Transition of pyruvate to acetyl-coA - Overview of the krebs cycle and its steps - NAD+ as a coenzyme in the krebs cycle - Accumulation of NADH during the cycle 4. Electron Transport Chain and NADH - Movement of pyruvate into the mitochondria - Role of NADH as an electron donor in the electron transport chain (ETC) - ATP production through the ETC 5. Factors Disrupting NAD+ Balance - Impact of toxins and pesticides on the ETC - Role of drugs, like NSAIDs, in inhibiting the ETC - Generation of reactive oxygen species (ROS) - Role of ROS in mitochondrial damage and NAD+ depletion - Link between NAD+ decline and aging 6. Consequences of NAD+ Depletion - Effect of NAD+ reduction on metabolism - Connection between NAD+ and metabolic diseases - Therapeutic potential of NAD+ in age-related diseases 7. 6 Strategies for NAD+ Restoration - Which supplemental NAD+ precursors are more effective - Inhibition of the CD38 enzyme using dietary nutrients - NAD+ IVs and patches: cost and quality - Intermittent fasting - Exercise and NAD+ - Other less well-known lifestyle factors that have a big impact on NAD+ 8. NAD+ Therapies to Support Recovery from Mold Illness - Link between NAD+ depletion and mold illness - Thoughts on and logic behind the use of NAD+ therapies for CIRS recovery
Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 27 Sep 2024 | 142. Neuroinflammation & Gut-Derived Lipopolysaccharides | Addressing Intestinal Dysbiosis, Intestinal Hyperpermeability, & Cognitive Function | Supporting the Gut-Microbiota-Brain Axis | 00:21:23 | |
In today's episode, we dive into the molecular mechanisms underlying neuroinflammation, with a particular focus on how gut-derived endotoxins, such as lipopolysaccharides (LPS), perturb the blood-brain barrier (BBB) and propagate neuroinflammatory cascades. In more detail, we’ll discuss how intestinal dysbiosis and increased intestinal permeability can allow endotoxins such as LPS to enter systemic circulation and cross the blood-brain barrier (BBB), where they activate microglia via the TLR4 signaling pathway. We will explore symptoms including brain fog, memory impairment, mood disturbances, decreased concentration, and cognitive fatigue; as well as tools to support the gut-microbiota-brain axis. Topics: 1. Introduction to Neuroinflammation - Definition and general overview - Key brain cells: neurons, glial cells, and endothelial cells - Chronic neuroinflammation and microglial cells 2. Cellular Mechanisms of Neuroinflammation - Role of microglia in detecting damage or infection - Microglial activation through PRRs/TLRs - Release of pro-inflammatory cytokines and reactive oxygen species (ROS) - Impact on neurons and synaptic plasticity: memory and learning 3. Astrocytes in Neuroinflammation - Astrocytes' contribution to the inflammatory response 4. Chronic Neuroinflammation and Brain Health - Prolonged activation: oxidative stress, excitotoxicity, impaired synaptic function - Impairment of synaptic plasticity and cognitive decline - Mitochondrial dysfunction and cell death cascades - Compromised blood-brain barrier integrity 5. Contributing Factors to Neuroinflammation - Environmental toxins and pollutants, viral or bacterial infections, chronic sleep deprivation, and more 6. Intestinal Dysbiosis and Neuroinflammation - Role of Gram-negative bacteria and LPS (lipopolysaccharides) - Increased intestinal permeability and passage of LPS - LPS transport: transcellular and paracellular pathways - Impact on the blood-brain barrier (BBB) 7. LPS Activation of Microglia - LPS binding to TLR4 on immune cells - Microglial activation and cytokine release - Cognitive impairments and neurodegenerative processes 8. Intestinal Hyperpermeability - Bioindividual approaches: prebiotics, probiotics, polyphenols, bacteriophages - Support for intestinal mucus secretions and sources of mucilage - Butyrate - Glutamine 9. Beneficial Gut Microbiome-Derived Metabolites and Brain Health - Types of metabolites: SCFAs, tryptophan metabolites, polyphenol metabolites - Role of butyrate in crossing the BBB and modulating brain function - Influence on gene expression and synaptic plasticity - Contribution to gut barrier integrity and protection against endotoxins 10. Conclusion - Recap of neuroinflammation's impact on cognitive function + symptoms
Thank you to our episode sponsor: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 26 Jul 2024 | 132. Bartonella (Lyme Co-Infection) - Pathology of the Bacterial Infection, Which Cells the Bacteria Invade, Symptoms Including Swollen Lymph Nodes & Skin Lesions / Striae, & More | 00:18:22 | |
In this episode, we dive into the complexities of Bartonella, a genus of gram-negative, facultative intracellular bacteria known for its ability to evade the immune system and persist in host cells such as endothelial cells and erythrocytes. We explore the specific pathogenesis mechanisms of Bartonella henselae, including its interaction with cell adhesion molecules which facilitate its intracellular entry and survival. Additionally, we discuss the clinical manifestations and epidemiological significance of Bartonella as a common co-infection in Lyme disease patients, emphasizing its role in chronic symptoms such as swollen lymph nodes and vascular-related skin lesions. Topics: 1. Introduction - Overview of Chronic Inflammatory Response Syndrome and biotoxin illness. 2. Overview of Bartonella - Definition and general characteristics of Bartonella as a genus of gram-negative bacteria. - Explanation of facultative intracellular pathogens and their survival mechanisms. 3. Transmission Modes - Common vectors: fleas, lice, ticks, and the role of arthropod vectors in Bartonella transmission. - Other transmission routes: animal scratches/bites (particularly from cats), contaminated needles / blood transfusions. 4. Pathogenesis of Bartonella - Initial entry and dissemination through the circulatory system. - Predilection for endothelial cells and specific mechanisms of endothelial cell invasion. - Role of Bartonella adhesin A and its interaction with fibronectin and integrins. - Signaling pathways and cytoskeletal changes leading to endocytosis. 5. Immune Evasion and Infection Persistence - Intracellular residency in endothelial cells to evade neutrophils. - Ability to infect and persist in red blood cells and macrophages. - Impact on lymph nodes and immune response leading to swollen lymph nodes. 6. Clinical Manifestations - Specific diseases caused by different Bartonella species: - Bartonella henselae: Cat scratch fever - Bartonella quintana: Trench fever - Bartonella bacilliformis: Carrion’s disease - Symptoms of Bartonella infections, including swollen lymph nodes, bone pain, and skin markings. - Severe cases leading to Bacillary Angiomatosis and vascular-related skin lesions. 7. Summary and Implications - Recap of Bartonella’s impact as a Lyme co-infection. - Reminder of the diversity of Bartonella species and their varied clinical presentations. - Importance of tailored medical guidance due to the complexity of co-infections. Thank you to our episode sponsor: Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 12 Feb 2024 | 101. Dr. Emily Splichal - Functional Podiatry - Strengthening the Feet to Optimize Body Movement, Enhance Circulation, & Activate the Nervous System; Plus, a Dive into Naboso Technology | 01:00:50 | |
We are honored to welcome Dr. Emily Splichal to the podcast. Dr. Emily Splichal, Functional Podiatrist and Human Movement Specialist, is the Founder of EBFA Global, Creator of the Barefoot Training Specialist® Certification, Author of Barefoot Strong and CEO/Founder of Naboso Technology. With over 20 years in the fitness industry, Dr Splichal has dedicated her medical career towards studying postural alignment and human movement as it relates to barefoot science, foot to core integration and sensory integration. Topics: 1. Introduction to Podiatry - Dr. Emily Splichal's motivation to enter the field of podiatry 2. Proprioceptive Training and the Importance of Feet - Explanation of proprioceptive training - Significance of feet in proprioception 3. Strengthening Feet and Its Impact on Whole Body Movement - Connection between foot strength, core, and glutes 4. Flat Feet: Impact on Training and Causes - Effects of flat feet on physical training - Common causes of flat feet 5. Barefoot Training vs. Modern Footwear - Comparison of barefoot training and modern footwear 6. Foot Complications and Conditions - Neuropathy and its effects on the feet - Micro vs. macro circulation and its impact on foot health - Plantar fasciitis and its causes 7. Benefits of Naboso Technology - Introduction to Naboso technology and its tools 8. Practical Approaches and Tools for Foot Health - Actions and strategies individuals can take to improve foot health - Description of tools and products developed by Naboso 9. Myofascial Release - Explanation of myofascial release techniques and their benefits Links for this episode: Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 01 Dec 2023 | 75. LLLT vs. LED Light Therapy: Which Wavelengths of Light (and Power Densities) Yield Therapeutic Benefits (Wrinkle Reduction, Lymphatic Drainage, & More) - Clearing Up Confusion Around Light Therapy | 00:33:28 | |
In today's episode, we are diving deep into light therapy, specifically comparing Low-Level Laser Therapy (LLLT) and LED Light Therapy. We are clarifying the crucial distinctions between these two forms of therapy, focusing on the significance of various wavelengths of light and power densities in achieving therapeutic benefits. We explore studies that examine the effectiveness of LLLT and LED Light Therapy in contexts such as wrinkle reduction and lymphatic drainage, shedding light on the science behind these treatments and helping to clear up common misconceptions. Stay tuned! Topics: 1. Chromotherapy DIY - Establishing Foundational Knowledge about the Physics of Light - Difference Between LEDs and Lasers - Electroluminescence in LEDs - Omnidirectional Light Emission in LEDs - Low Coherence in LEDs - Population Inversion in Lasers - Stimulated Emission in Lasers - Highly Coherent and Amplified Beam in Lasers - Importance of Understanding Light Physics in Interpreting Scientific Studies - Risk of Misleading Information - Influx of Fake Chromotherapy Devices 2. Power and Power Density in Light Therapy - Radiant Power - Power Density or Irradiance - Significance in Light Therapy Devices - Determining Laser Performance - Evaluating Red Light Therapy LED Devices 3. Low-Level Laser Therapy (LLLT) - Properties of LLLT - Power Output (0.001-0.1 Watts) - Wavelength (300-10,600 nm) - Pulse Rate (0-5000 Hertz) - Intensity (0.01-10 W/cm²) and Dose (0.01-100 J/cm²) - Mechanism of LLLT - Photochemical Effect - Application in Tissue Regeneration, Inflammation Reduction, and Pain Relief 4. Studies on Light Therapy - Study on LLLT for Skin Rejuvenation - Parameters: 635 nm, 10mW power, 15-minute sessions, 6 weeks - Wrinkle Reduction and Collagen Upregulation - Study on LLLT Effects on Lymphatic Flow and Lymphedema - Parameters: 904 nm, 1.5 J/cm², 17-minute sessions, 9 sessions over 3 weeks - 90 ml Reduction in Upper-Limb Volume and Improved Quality of Life - Potential for Other Wavelengths of Light in Therapy (Yellow, Blue, Green, etc.)
5. Conclusion and Future Topics - Expanding the Understanding of Light Therapy - Exploring Therapeutic Uses of Lasers and LEDs in Dentistry, Cosmetics, Collagen Production, ATP Upregulation, and More
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 02 Feb 2024 | 99. Making Your Own DIY Hydrogen Water (+ Cautions) & How Hydrogen Water Helps to Combat Insulin Resistance | 00:24:32 | |
In this episode, we will explore what hydrogen water is, its cellular effects, and its connection to conditions like metabolic syndrome/insulin resistance. Additionally, we'll uncover how many individuals make their own hydrogen water without the need for expensive machinery or supplements; we will do this while highlighting important safety precautions. Topics: 1. Introduction - Mention of creating hydrogen water without supplements or machinery 2. What is Hydrogen Water? - Definition and composition - Role of molecular hydrogen at the cellular level - Antioxidant properties and its role in combating oxidative stress - Effects on inflammatory pathways, gut microbiome, and metabolic syndrome 3. Connection to Metabolic Syndrome - Study on hydrogen water consumption and its effects on metabolic syndrome - Reduction in oxidative stress and lipid peroxidation - Significance of lipid peroxidation for metabolic health and insulin resistance 4. Creating Hydrogen Water - Chemistry behind the reaction - Different methods of producing hydrogen water (without machinery or tablets) - Using magnesium rods - Use of malic acid + magnesium rods - A study's protocol on using just the magnesium rods - Importance of air-tight seals and precautions with pressure - Cooling the water to retain dissolved hydrogen 5. Cautionary Measures - Concerns about purity of magnesium rods (contamination with lead, for example) - Potential risks of consuming too much metallic magnesium - Pressurized bottles and potential for "explosion" 6. Conclusion - Recap of key points - Emphasis on safety and consulting medical professionals
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 21 Mar 2023 | 10. Aimee Allenback - Hyperbaric Oxygen Therapy 101, Protocols, Stacking Treatments, and More! | 00:58:06 | |
Welcome to the 10th episode of The Synthesis of Wellness podcast! Aimee was such an awesome guest with a passion for not only HBOT, but all things wellness! I loved having her on the show, and I know you'll love this episode! A little bit about her: Aimee is a certified International Hyperbaric Technician by the International Board of Undersea Medicine (IBUM) and owner of Next Level Oxygen Hyperbaric MedSpa. She is formerly a product specialist for the number one manufacturer of portable hyperbaric chambers, and continues to be an authorized retailer of those products. Aimee was introduced to HBOT in 2005 while working as the Development Director for the National Autism Association, and became a regular user of HBOT in 2015 to address auto-immune issues. When Aimee isn't helping clients improve their health and well-being, she dedicates time to another passion, flying the friendly skies as a Flight Attendant. Topics: - Aimee's story and how she got into hyperbaric oxygen therapy (HBOT) - What is hyperbaric oxygen therapy? - The science behind HBOT. - Does it benefit the lymphatic system and other detoxification pathways? - Who can benefit from it? - Cosmetic uses: skin & collagen production. - Treatment schedule/how often should someone receive HBOT? - Any beneficial supplements to take prior to or following a session? - How can someone get the most out of a session. - Other wellness treatments to stack with HBOT. Check out Aimee on Instagram: @nextleveloxygen
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| 23 Aug 2024 | 137. Supporting Brain Health & Cognitive Function by Harnessing the Power of the Gut Microbiome | Focusing on Microbial Metabolites Including SCFAs & Indole-3-Propionate | 00:28:19 | |
In today's episode, we dive into the crucial roles that gut-derived microbial metabolites, particularly short-chain fatty acids and tryptophan metabolites, play in supporting the health of neurons and glial cells, ultimately promoting cognitive function. We explore how enhancing the body’s natural production of these metabolites through a healthy gut microbiome and how strategic supplementation can both benefit brain health. The discussion includes detailed insights into the cellular mechanisms in the brain and practical strategies for fostering a healthy gut microbiome capable of producing high quantities of these beneficial compounds. Topics: 1. Introduction to Brain Cellular Makeup - Overview of Neurons and Glial Cells - Neurons: Structure and Function - Glial Cells: Types and Roles 2. Neuronal Communication and Synaptic Function - Neuronal Structure: Soma, Dendrites, Axon - Synaptic Communication: Presynaptic Terminal, Synaptic Cleft, Postsynaptic Membrane 3. Energy Demands - ATP Utilization and Energy Demands - Mitochondrial Function and Neuronal Vulnerability 4. Astrocytes and Microglial Cells - Astrocytes: Functions and Role in CNS Homeostasis - Microglial Cells: Immune Functions and Role in Neuroinflammation 5. Roles of Gut-Derived Microbial Metabolites in Supporting Brain Health - Overview of Gut-Derived Metabolites - Short-Chain Fatty Acids (SCFAs): Acetate, Propionate, Butyrate - Tryptophan Metabolites: Indole, Indole-3-Propionate (IPA) 6. Impact of Gut-Derived Metabolites on Neurons - Promotion of Neurogenesis by SCFAs - Neuroprotective Effects of Tryptophan Metabolites 7. Impact of Gut-Derived Metabolites on Glial Cells - Impact on Astrocytes - Impact on Microglial Cells 8. Strategies to Enhance Metabolite Production - Diversity - Probiotic Supplementation - Fiber - Amino Acids 9. Direct Supplementation Options - Sodium Butyrate: Role in Neuroprotection and Cognitive Function Thank you to our episode sponsors: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. 2. Check out AX3 Astaxanthin and use discount code CHLOE20 for 20% off your first order. 3. Check out Liver Medic and use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 13 Dec 2024 | 155. The Gut-Immune Axis & The Role That Gut-Microbiome Metabolites / Postbiotics Play | SCFAs, Polyphenol Metabolites, & Supporting Butyrate Production | 00:16:08 | |
In this episode, we dive into the interplay between the gut microbiota (their postbiotics) and the immune system. We will examine how gut microbiome-derived metabolites, such as short-chain fatty acids (SCFAs) and polyphenol metabolites, influence immune function by modulating key cellular and molecular pathways within the intestinal mucosa. Additionally, we discuss strategies for supporting butyrate production and optimizing microbiome health to foster a balanced and resilient gut-immune axis. Topics:
11. Specific Polyphenols
Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter
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| 20 Nov 2023 | 70. Dr. Deanna Minich - Using Melatonin to Reset Your Circadian Rhythm, When to Supplement, & Supporting Your Body's Natural Melatonin Stores Through Light Exposure and Diet | 00:54:55 | |
We are honored to be joined by Dr. Deanna Minich, a distinguished nutrition scientist, educator, and author with over two decades of experience in academia and the natural product industries. Currently serving as Chief Science Officer at Symphony Natural Health, she has also made significant contributions as a functional medicine clinician in clinical trials and through her own practice known as Food & Spirit™. Dr. Minich is a prolific writer, having authored six consumer books on wellness, multiple book chapters, and over fifty scientific publications. With that said, we are truly honored to have her on! Topics: 1. Melatonin Basics - Definition and role in the body. 2. Imbalance and Symptoms - Causes of melatonin imbalance. - Associated symptoms. 3. Assessing Levels - Methods to gauge melatonin adequacy. 4. Dietary Sources - Foods containing melatonin. 5. Biohacking Tips - Strategies for optimizing melatonin. 6. Phytomelatonin vs. Synthetic - Distinction between natural and synthetic melatonin. 7. Historical Uses - Traditional applications of melatonin supplements. 8. Modern Applications - New uses and emerging research. 9. Supplement Considerations - Who should consider melatonin supplements. - Safety precautions.
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 22 Sep 2023 | 45. Don Moxley - The Power of Spermidine for Autophagy & Why Autophagy is Essential for Longevity Plus a Conversation on HRV, Factors That Affect it, & How to Increase it | 00:54:56 | |
We are so honored to welcome Don Moxley to the show! Don Moxley, Director of Applied Science at LONGEVITY LABS+ and co-creator of HRV+, boasts 30 years in the sports realm. A former Big 10 Championship winner for Ohio State University, he later became the institution's pioneering sports scientist. Using his innovative approach with HRV, he played a role in achieving two Olympic medals, four world championships, and seven National Championships. Beyond these accolades, Don is dedicated to advancing human performance for all, with a focus on wearable tech, fitness, and nutraceuticals. I absolutely loved this conversation with Don. His expertise is unparalleled, and his dedication to helping others is admirable! Topics: 1. Understanding Autophagy - Explanation and primary function of autophagy for our cells. - Mechanism of autophagy at the cellular level. - Role in aging and longevity. - Benefits and potential pitfalls: Is there too much autophagy? 2. Factors Influencing Autophagy - Conditions known to increase autophagy. - Factors that might decrease or inhibit the process. 3. Role of Spermidine in Autophagy - Spermidine and its significance. - Increasing spermidine intake: food sources and supplements. - Longevity Labs' Spermidine Supplement 4. Introduction to Heart Rate Variability (HRV) - Explanation and determination of HRV as a health metric. - Impacts of different HRV levels on health. 5. Modulating HRV Levels - Factors and supplements that might influence HRV levels. - Mode + Method: HRV+ Supplement Thanks so much for tuning in! Check out more of Don Moxley here! Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 18 Oct 2024 | 146. Neuroinflammation | How Chronic Microglial Cell Activation Can Contribute to Neurodegeneration, Factors That Activate Microglial Cells | 00:17:45 | |
In this episode, we dive into the role of microglial cells, the brain’s resident immune defenders, and how their chronic activation at the cellular level contributes to neurodegeneration. We'll explore the cellular mechanisms behind microglial activation, including the involvement of P2Y12 receptors and the release of pro-inflammatory cytokines like IL-1β and TNF-α. Additionally, we'll discuss how everyday environmental toxins and stressors can trigger long-term microglial activity, potentially increasing the risk of conditions like Alzheimer's. Topics: 1. Introduction - Overview: Microglia and neurodegeneration. - Environmental toxins affecting microglia. 2. Brain and Microglial Overview - Brain has neurons and glial cells. - Microglia are the brain's immune cells. - Roles: Immune defense, synaptic pruning, neuroprotection. 3. Microglial Immune Function - Constantly monitor for infection and damage. - Activated microglia perform phagocytosis. - Clear debris and maintain brain health. 4. Cellular Mechanisms of Activation - P2Y12 receptors respond to ATP/ADP. - Microglia shift from resting to activated. - Activated microglia are highly phagocytic. 5. Role in Synaptic Pruning - Microglia help in synaptic pruning. - Remove weak synapses for efficient brain circuits. 6. Microglia in Neurodegeneration - Chronic activation leads to inflammation. - Release of cytokines like IL-1β, TNF-α, IL-6. - Contributes to Alzheimer's, Parkinson's. - MHC molecules 7. Environmental Toxins and Activation - Mycotoxins cross BBB and activate microglia - Heavy metals like lead, aluminum affect neurons - Pesticides/herbicides linked to Parkinson’s risk 8. Other Factors Activating Microglia - Industrial chemicals, BPA - Artificial additives, alcohol - Chronic stress 9. Conclusion - Recap: Microglial functions and overactivation. - Lifestyle factors influence microglial health. Thank you to our episode sponsors: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. 2. Check out the TruAge Biological Age Test from TruMe Labs. Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! | |||
| 22 Nov 2022 | 4. Sylwia Tabor Founder of Carnivore Snax, Carnivore Diet, Gut Health | 00:52:15 | |
Welcome to the 4th episode of The Synthesis of Wellness podcast! Today, we have an amazing and inspirational conversation with Sylwia Tabor, one of the founders of Carnivore Snax. Carnivore Snax is the next generation of meat snacks quickly replacing its additive and sugar-filled counterpart: jerky. This episode takes an in-depth look at Sylwia’s story, the motivation behind the brand, and how the carnivore diet can be a therapeutic tool to regaining gut health. Topics: - Sylwia’s story and health battles - Sylwia’s experience on the vegan diet - Sylwia’s experience on the carnivore diet - Finding balance with the carnivore diet and using it as a short-term tool - Avoiding plant-foods long-term might lead to dysbiosis or a lack of digestive enzymes - Carnivore diet thrives when it comes to decreasing gut inflammation - Are we really meant to eat carnivore or keto long-term? Or maybe, are we meant to use it therapeutically? - Why it’s important to modify a diet to meet your specific needs - Probiotics versus peptides - How Sylwia started to introduce more foods into her diet after carnivore - A short discussion on Sylwia’s battle with histamine intolerance - Why getting sunshine is so important not only for circadian rhythm but digestion as well - Sylwia’s SIBO experience and how she combat’s a SIBO flare - Sylwia’s digestion tips (what works for her): overcooking foods for digestibility, HCL supplementation, digestive enzymes - Where Sylwia is at now with her health - Gut testing and supplements - The gold standard gut test: Genova 360 - SIBO testing: testing for all three types of SIBO - Sylwia’s non-negotiables - Sylwia’s diet preferences - Sylwia’s advice for health and happiness: don’t give up on your health! Get help and keep looking! - Carnivore Snax is the perfect clean snack Thanks so much for listening! Go check out Carnivore Snax at https://carnivoresnax.com/?rfsn=6934691.4b1a32 Use code CHLOE15 to get a 15% off discount! And follow @carnivore.snax on Instagram! | |||
| 30 Aug 2024 | 138. Pathogenicity of Candida Overgrowth | Understanding Candida-Produced Proteases, Phospholipases, & Candidalysins; Symptom Causation; & Key Strategies to Address Pathogenic Overgrowth | 00:23:37 | |
In today's episode, we explore the complex interactions between Candida and the gastrointestinal tract, examining how this fungus can transition from harmless commensal to pathogenic state that disrupts gut barrier functions. We dive into Candida's ability to undermine mucosal integrity through the production of candidalysin and other virulence factors like secreted aspartyl proteases, which specifically target and degrade tight junction proteins such as claudins and occludins. We'll explore the layered structure of the intestinal mucus barrier, its role in immunological defense, and how Candida's biofilm-forming capabilities further facilitate its pathogenicity. Lastly, we'll discuss tools and strategies for mitigating Candida overgrowth. Topics: 1. Gastrointestinal Tract Anatomy / Barrier Function - Mucus Layer - Description of the gastroprotective mucus barrier - Differences in mucus architecture between the small and large intestines - Composition: mucins, immunoglobulins (IgA), antimicrobial peptides - Intestinal Epithelium - Structure and function of the epithelial cell layer - Roles of different epithelial cells: enterocytes, goblet cells, enteroendocrine cells, Paneth cells - Lamina Propria - Immune cell types 2. Integrity of Tight Junctions - Tight junction proteins: claudins, occludins, junctional adhesion molecules (JAMs) - Mechanisms of tight junction regulation and response to changes in the gut environment - Impact of physiological and pathological factors on tight junction dynamics 3. Candida Pathogenicity Mechanisms - Adherence and Biofilm Formation - Mechanisms facilitating Candida adherence to epithelial cells - Structural and functional implications of biofilm formation - Enzymatic Disruption of Tight Junctions - Role of Candida-secreted aspartyl proteases (Sap) and phospholipases in degrading tight junction components - Immune System Interaction - Triggering of inflammatory cytokines by Candida presence and their effects on gut barrier function 4. Candidalysin: A Specific Virulence Factor - Genetic basis for candidalysin production via the ECE1 gene - Mechanism of action: disruption of epithelial cell membrane integrity, pore formation, and cellular damage 5. Clinical Manifestations of Candida Overgrowth - Gastrointestinal symptoms: bloating, gas, diarrhea, constipation, abdominal pain - Systemic effects: fatigue, brain fog, skin issues, mood disturbances - Nutrient absorption impairments leading to deficiencies 6. Strategies - Biofilm Disruption - Agents targeting biofilm integrity and adherence properties - Antifungal and Enzymatic Tools - Natural antifungals - Role of enzymatic supplements in biofilm and cell wall degradation - Immune Modulation and Gut Microbiota Support - Immune-modulating agents - Probiotics and prebiotics to restore and maintain healthy gut flora
Thank you to our episode sponsors: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. 2. Check out Liver Medic and use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
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| 29 Jan 2025 | 162. Supporting Methylation and Optimizing Vitamin B12 Utilization Through the Vitamin B12 Protocol with Chris Soppet, Founder of Spectrum Sciences | 00:56:22 | |
We are honored to be joined today by Chris Soppet. Chris is the founder of Spectrum Sciences, a health and wellness brand with the vision of bringing the healing power of vitamin B12 to the greatest number of folks out there. He received his inspiration from his son, who recovered from autism in large part due to the remarkable power of vitamin B12. Chris shares this hope through a very tangible means – The Vitamin B12 Protocol. After using various other B12 products on the market, he was disappointed by the inconsistency and lack of transparency. As a chemist and certified health coach, he was uniquely positioned to take matters into his own hands. Launched in the Fall of 2024, Spectrum Sciences aims to deliver the most effective, safe, and transparently labeled option in transdermal delivery of nutrients. Topics: 1. Chris' Journey and Developing Spectrum Sciences - Chris Soppet's background and the inspiration for founding Spectrum Sciences. 2. Brief Overview of The Vitamin B12 Protocol 3. Brief Overview of Methylation - The importance of methylation for cellular function and overall health. 4. Background - The role of the thyroid in supporting methylation and B12 utilization, including testing, nutrients, and understanding a basic thyroid panel. - The thyroid’s role in activating riboflavin (B2) and other cofactors, and how activated riboflavin is used. - How to support riboflavin status through dietary intake. - The folate cycle and how activated riboflavin supports the MTHFR enzyme to yield active folate. - The interaction of B12 and B9 in converting homocysteine to methionine and producing SAM, the universal methylator. 5. The Organic Acids Test - Explanation of the test and its insights. 6. Topical Serums - Benefits of topical delivery. - Spectrum Sciences' products that support thyroid function. - Spectrum Sciences' products that support riboflavin activation with thyroid assistance. - Spectrum Sciences' activated B12. - Remarkable transdermal delivery through microemulsion technology. - How to use the topicals. 7. Spectrum Sciences LLC - Resources for learning about Spectrum Sciences, The Vitamin B12 Protocol, and topical serums. 8. Connecting with Chris Soppet - Social media and website links to learn more about Chris and Spectrum Sciences. Check out Spectrum Sciences and The Vitamin B12 Protocol at spectrum-sciences.net, and use code CHLOE15 for 15% off. Follow Spectrum Sciences on Instagram @spectrumscience1 | |||
| 02 Oct 2023 | 49. Svetinorm Bioregulator Peptide (Peptides Episode) - How this Liver-Specific Peptide Revitalizes Hepatocytes (+ Symptoms of Poor Hepatocyte Function), Supports Liver Detox, & Improves Digestion | 00:32:26 | |
We are diving into a pretty amazing bioregulator peptide called Svetinorm. Extracted from liver cells, this bioregulator peptide has been shown to help restore function to hepatocytes, improve conditions of hepatitis, decrease symptoms such as fatigue and indigestion, and more. All-in-all, the liver is critical for detoxification, processing excess hormones, producing bile, and more, so ensuring that the hepatocytes are functioning correctly is paramount! Stay tuned - this peptide is a game-changer... Topics: 1. Introduction to Liver Detoxification and Svetinorm - Overview of liver detoxification processes. - Introduction of Svetinorm as a bioregulatory peptide derived from cattle liver cells. 2. Liver Function and Structure - Exploration of the vital role of the liver in detoxification, metabolism, and overall health. - Description of the anatomical structure of the liver. - Introduction of hepatocytes as the primary functional cells responsible for various liver functions. 3. Blood Flow and Hepatic Lobules - Details about the intricate blood flow within the liver. - Discussion of hepatic lobules as the fundamental structural units of the liver. - Highlighting the hexagonal shape of hepatic lobules and their central hepatic vein. - Explanation of the role of sinusoidal endothelial cells in facilitating molecule exchange between blood and hepatocytes. - Description of how these cells line the walls of sinusoids within hepatic lobules. 4. Hepatocyte Detoxification Process - Toxins entering the bloodstream and reaching hepatocytes. - Explanation of Phase I metabolism, involving cytochrome P450 enzymes modifying toxins. - Introduction of Phase II metabolism or conjugation, where toxins become more water-soluble. - Examples of common conjugation agents such as glucuronic acid, sulfate groups, glutathione, amino acids, acetyl groups, methyl groups, and others. 5. Toxin Elimination Pathways - Explanation of the routes for water-soluble conjugates to exit the liver. - Details about options for conjugates to reenter the bloodstream or enter the bile. - Mention of how toxins may be further processed and eliminated through urine, feces, or bile. 6. Impaired Hepatocytes and Associated Symptoms - Discussion of the consequences of impaired detoxification pathways and dysfunctional hepatocytes. - Enumeration of common symptoms that may arise from liver dysfunction, such as fatigue, skin issues, digestive problems, bloating, fluid retention, inflammation, and hormone imbalances. 7. Svetinorm - Clinical studies - Proposed mechanisms: bioregulatory peptides 8. Administration - Details about recommended Svetinorm dosage and administration methods. - Highlights of clinical studies, primarily focused on chronic hepatitis patients. - Notation of the positive outcomes observed in these studies, such as improved energy and decreased dyspepsia. - Always work with a licensed medical professional. 9. Personal Experience with Svetinorm - Sharing personal perspectives and experiences with Svetinorm for detoxification and liver support during CIRS Thanks so much for tuning in! Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" TODAY! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! | |||
| 27 Nov 2023 | 73. Erika Straub - Identifying Triggers, Healing Past Trauma, Challenging Yourself to Say No, & Much More! | 00:48:31 | |
We are deeply honored to have Erika Straub as a guest on our podcast. Erika's remarkable journey from therapist to self-development entrepreneur is truly inspiring. She shares her wisdom through teaching, mentoring, writing, and speaking on an international platform. Erika's transformative work focuses on helping individuals navigate the path from trauma to love and leadership. She encourages people to embrace vulnerability and responsibility, guiding them towards a profound transformation. And, I love that! Topics: 1. Navigating Life Transitions - Handling anxiety and uncertainty during transitional phases. - Strategies for a smoother transition. 2. Challenges of Adulthood - Common struggles associated with "adulting." - Practical advice for addressing these challenges. 3. Overcoming Isolation and Loneliness - Dealing with feelings of isolation and being left behind. - Initial steps to connect with others and combat loneliness. 4. Self-Discovery and Meeting Needs - Tools and techniques for better understanding personal needs. - Strategies for self-care and personal growth. 5. Thriving vs. Surviving - Transitioning from survival mode to a thriving life. - Tips for embracing a more fulfilling lifestyle. 6. Rewiring Dysfunctional Habits - Success stories and effective methods for breaking ingrained patterns. - Techniques for building healthier habits. 7. Setting and Maintaining Boundaries - The importance of boundaries for mental health. - Coaching on confidently establishing and enforcing boundaries. 8. Healing from Childhood Trauma - Approaches to process and heal from deep-rooted childhood trauma. - Strategies for emotional healing and growth.
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 06 Dec 2024 | 154. Dysautonomia, The Vagus Nerve, & The Microbiota-Gut-Brain Axis | The Role That the Vagus Nerve Plays in Intestinal Health, Conditions and Root Causes Associated with Poor Function | 00:16:54 | |
In this episode, we explore the intricate role of the vagus nerve as a central regulator within the microbiota-gut-brain (MGB) axis, examining its neuroanatomical structure, signaling mechanisms, and interactions with microbial metabolites and immune pathways. We discuss how vagal afferent fibers relay sensory input from the gut to the brain, including signals mediated by short-chain fatty acids (SCFAs) and gut-derived hormones, and how efferent fibers modulate gut motility, intestinal barrier integrity, and inflammation through the cholinergic anti-inflammatory pathway. Finally, we explore vagal dysfunction as well as associated conditions and symptoms, and we touch on just a few potential root causes. Topics:
Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter
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| 08 Dec 2023 | 78. Photoactivated Disinfection in the Oral Cavity (An Often-Overlooked Area That MUST be Treated to Fully Heal) + Why PAD is Extremely Relevant for Biotoxin Illness, Candida Overgrowth, & More | 00:23:46 | |
In today's episode, we explore Photo-Activated Disinfection (PAD) in the oral cavity using Low-Level Laser Therapy (LLLT). We'll break down the science behind this innovative approach, its potential applications, and its relevance in addressing biotoxin illnesses, candida, and other chronic health conditions. This is a great episode to listen to if you are having a difficult time fully recovering from biotoxin illness, candida, gut dysbiosis, etc... Topics: 1. Introduction - Overview of Photo-Activated Disinfection (PAD) in the Oral Cavity - Relevance of PAD for Biotoxin and Chronic Illness 2. How Photo-Activated Disinfection (PAD) Works - Photosensitizer Application - Absorption by Microbes - Activation of Photosensitizer by Laser Light - Generation of Reactive Oxygen Species (ROS) - Microbial Cell Damage - Overall Disinfection 3. Examples of Photosensitizers and Their Absorption Peaks - Toluidine Blue, Methylene Blue, and Chlorin e6 Conjugates - Indocyanine Green 4. Studies Illustrating the Use of PAD with Low-Level Laser Therapy (LLLT) - Study on E. faecalis Infection in Root Canals - Photodynamic Fungicidal Efficacy Against Oral Candida albicans 5. Relevance of PAD Using LLLT for the Entire Body - Impact of Oral Pathogens and Biotoxins on the Brain - Neuroinflammation and Alzheimer's Risk - Connection between Oral Infections and Neurodegeneration - Impact of Oral Dysbiosis on the Gut - Dysbiosis in Oral and Gut Microbiomes - Risk of Swallowed Pathogenic Microbes 6. Conclusion and Potential Applications of LLLT with PAD - Promising Literature on LLLT with PAD - Availability from Holistic or Biological Dentists
Thanks for tuning in! Book An Intro Coaching Call with Chloe Porter Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 12 Jun 2023 | 16. My Biohacked Summer Wellness List - 25 Ideas for Wellness Upgrades | 00:32:04 | |
Welcome to the 16th episode of The Synthesis of Wellness Podcast! Today, we're having a little bit of fun, so here is a solo episode about biohacking goals/ideas/thoughts for the summer. I hope you enjoy! Topics: - Introductory quote of the day - 25 Biohacks/Ideas for Summer Wellness Resources: Follow @synthesisofwellness on Instagram to see more of Chloe! Or, visit synthesisofwellness.com | |||
| 14 Aug 2023 | 28. Candida Toolkit - Breaking Down Biofilms, Antifungals, Attacking the Fungal Cell Wall, Blocking Fungal Cell Adhesion to the Gut Mucosa, & More | 00:38:35 | |
In today's episode, we will delve into a research-backed candida toolkit, exploring the cellular structure of candida microbes and presenting scientifically supported strategies to target and eliminate candida overgrowth. Thank you so much for tuning in! Topics: 1. Understanding candida - Overview of candidiasis and Candida albicans - Candida albicans as part of the body's microbiota 2. Symptoms and related conditions of candida overgrowth - Digestive symptoms (bloating, gas, diarrhea, constipation) - Fatigue and recurrent yeast infections - Cognitive and mood symptoms (brain fog, difficulty concentrating, mood swings) - Skin and nail infections, sugar cravings 3. Candida's metabolic pathways and adaptability - Fuel sources for Candida albicans (glucose, fructose, galactose) - Cell wall composition and remodeling - Moonlighting proteins and adaptability - Transition from yeast to hyphal form 4. Strategies to address candida overgrowth - Blocking fungal cell wall and immune evasion
- Blocking fungal cell adhesion
- Blocking biofilm formation or destroying biofilms
- Blocking the yeast to hyphal transition
- Blocking key pathways for candida albicans cell proliferation or metabolism
- Enhancing anti-fungal immune activity
5. Conclusion - Summary of candida strategy toolkit - Importance of a holistic approach to address candida overgrowth
Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness, or use the link: https://www.instagram.com/synthesisofwellness/ Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 29 Nov 2023 | 74. Dr. Stephanie Seneff - Deuterium, The Molecule That Underlies Mitochondrial Dysfunction + Strategies to Decrease Both Deuterium Use & Quantity Within The Body | 00:55:17 | |
We are truly honored to have Dr. Stephanie Seneff as our guest on the podcast. With over five decades of continuous affiliation with MIT and an impressive academic journey, including four degrees from MIT and extensive research experience in various fields, she brings a wealth of knowledge and expertise to our discussion. Dr. Seneff's more recent focus on the crucial role of nutrition and environmental factors, particularly glyphosate and sulfur, in human health adds an amazing perspective to our conversation. Topics:
Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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| 29 Dec 2022 | 7. Dr. Ken Brown - Microbiome Deep Dive, Why Your Supplements Might Not be Working, and Much More! | 01:01:59 | |
Welcome to the 7th episode of The Synthesis of Wellness podcast! Today, we have Dr. Ken Brown, a board-certified gastroenterologist and world-renowned expert on all things gut-health! He developed Atrantil, an all-natural & clinically proven answer for IBS & bloating, including SIBO! Furthermore, due to the amazing success of Atrantil, Dr. Brown has developed another supplement to complement Atrantil, called Atrantil Pro. All-in-all, he is bridging the gap and providing research-backed, natural solutions for people all over the world! You DON’T want to miss this information-packed episode! Topics: - Atrantil and Atrantil Pro - Dr. Brown’s recently-launched, daily supplement pack for SIBO - A follow-up to Dr. Dempsey’s episode: Microbiome deep dive - Polyphenols are used by gut microbes to produce smaller beneficial, anti-inflammatory metabolites that the body uses to maintain optimal health. - These metabolites have a range of benefits: gut motility, inflammation, brain health, immune health, and more - A poor microbiome (ie. dysbiosis) leads to harmful metabolites - The microbiome takes a little time to build up and diversify - Large & stable polyphenols are metabolized by the microbiome to produce metabolites we commonly supplement with such as quercetin. Therefore, a restored microbiome will provide you with those metabolites without needing to supplement. - “Sporebiotics” vs. Probiotics - How exactly do sporebiotics work? - Sporebiotics are emerging and could be an ultimate gut health biohack - You can buy hundreds of supplements OR you can optimize your gut and get the same benefits - Genetic diversity of the gut microbiome - Fecal microbial transplant research - Rebuilding the gut microbiome - We share our microbiota with those around us! - The effect of “polyphenols vs. polyphenols + exercise” on the microbiome - Sporebiotics don’t work like probiotics and, therefore, might be okay to use even in SIBO cases - The microbiome is the key to unlocking the potential of your supplements - Dr. Brown’s 1 piece of advice for health and happiness | |||
| 29 Dec 2023 | 86. Topical Cosmetic Peptides & Growth Factors (Part 2) - Uses and Function of Individual, Specific Peptides Designed to Stimulate Collagen, Mimic Botox, Reduce Skin Irritation, & More | 00:24:53 | |
Building upon our previous discussion on growth factors like EGF and FGF (featured in episode 84: part 1), we'll explore a range of intriguing peptides that have gained popularity for their skin-enhancing properties. From stimulating collagen production to calming irritated skin and even targeting dynamic wrinkles (acting like "botox in a bottle"), we'll cover a variety of topical peptides that are revolutionizing skincare. Stay tuned for this topical cosmetic peptide guide! Topics: 1. Introduction - Recap of last week's episode on growth factors (EGF and FGF) - Shift in focus to topical peptides - Skin anatomy for context 2. Skin Anatomy Overview - Epidermis - Layers and sublayers - Cornification process - Function of each sublayer - Dermis - Papillary and reticular dermis - Role of fibroblasts - Components and functions of the dermis 3. Topical Peptides - Palmitoyl Tripeptide-1 - Mimicking collagen - Stimulating collagen production - Benefits for skin structure and sagging prevention - Palmitoyl Tetrapeptide-7 - Relation to IgG protein - Reduction of IL-6 secretion and inflammation - Use in calming irritated skin - Palmitoyl Tripeptide-8 - Soothing irritated skin or for sensitive skin - Reduction of inflammatory cytokines like IL-8, edema, and capillaries - Palmitoyl Tetrapeptide-38 (Matrixyl 6000) - Comprehensive stimulation of skin matrix components - Greater collagen production and epidermal support - Benefits for skin structure, firmness - Neurotransmitter-Inhibiting Topical Peptides - Targeting dynamic wrinkles caused by muscle contraction - Reduction of muscle contractions and expression lines - Introduction of Acetyl Hexapeptide-8 and Acetyl Octapeptide-3 4. Other Topical Peptides (Future Episode & Featured on My Instagram) - Eyelash growth and nail growth peptides - Solutions for under-eye bags and dark circles
Thanks for tuning in! Book An Intro Coaching Call with Chloe Porter Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! Or visit linktr.ee/synthesisofwellness to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!
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