The Empowering Neurologist Podcast (David Perlmutter)

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Welcome back to The Empowering Neurologist! In this episode we have a truly fascinating conversation lined up with none other than Dr. Steven Gundry, a world-renowned heart surgeon-turned-functional medicine expert, whose work has transformed the way we understand diet, disease, and longevity.

Dr. Gundry is no stranger to challenging conventional medical wisdom. In his latest book, The Gut-Brain Paradox: Improve Your Mood, Clear Brain Fog, and Reverse Disease by Healing Your Microbiome (HarperCollins; April 15, 2025), he flips the script on the traditional gut-brain connection. His research reveals a startling truth: your microbiome is not just influencing your brain—it’s controlling it.

For years, we’ve heard that the brain sends signals to the gut. But Dr. Gundry shows that it’s actually the other way around: the microbes in our gut are shaping our thoughts, emotions, and even personality. From food cravings to mental health struggles, from cognitive decline to addiction—these tiny gut-dwelling organisms are the real puppet masters. And when our gut falls out of balance, neurological dysfunction follows.

In this episode, we’ll explore:

✅ How gut bacteria influence cravings, mood, and even personality

✅ The surprising link between gut inflammation and drug tolerance

✅ Why a leaky gut can lead to brain fog, neurodegeneration, and mental health issues

✅ How to reclaim control of your mind by healing your microbiome

Dr. Gundry lays out a powerful, science-backed plan to restore gut health and optimize brain function, mental clarity, and emotional well-being. If you’ve ever struggled with brain fog, anxiety, depression, or unexplained neurological symptoms, this episode is a must-listen. Tune in to this eye-opening conversation and discover how fixing your gut provides an important step to unlocking your brain’s full potential.

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00:00 Introduction

03:00 Why a Heart Surgeon Wrote a Book on the Brain

06:18 The Forgotten Hero Who Was Beaten to Death for Washing His Hands

09:08 A Parkinson’s Case Reversed by Healing the Gut?

13:28 Gluten Cross-Contamination and a Son’s Cutting Board: A Shocking Relapse

19:16 Gut Leaks, Brain Barriers, and Immune Sabotage: The Mechanism Explained

23:15 The Alzheimer’s Barrier Theory: Why Beta-Amyloid Might Be the Brain’s Defense System

26:20 Can Depression Be Healed Through the Gut?

30:27 Are Bacteria Controlling Your Addictions and Cravings?

34:02 The Scariest Mind-Control Parasite You’ve Never Heard Of

38:41 Eat This, Not That: How to Hack Your Gut for Better Brain Health

41:23 Neu5Gc and How it Impacts Our Brains

48:03 Are Polyphenols the Brain’s Secret Weapon?

56:38 Dead Bacteria, Live Benefits: Why Your Probiotic Doesn’t Need to Survive

01:05:05 Conclusion and Thank you

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Steven R. Gundry, MD, is the director of the International Heart and Lung Institute in Palm Springs, California, and the founder and director of the Center for Restorative Medicine in Palm Springs and Santa Barbara. After a distinguished surgical career as a professor and chairman of cardiothoracic surgery at Loma Linda University, Dr. Gundry changed his focus to curing modern diseases via dietary changes. He has written more than three hundred articles published in peer-reviewed journals on using diet and supplements to eliminate heart disease, diabetes, autoimmune disease, and multiple other diseases. He is the host of the top ranked nutrition podcast The Dr. Gundry Podcast and founder of Gundry MD, a wellness brand. Dr. Gundry lives with his wife, Penny, and their dogs in Palm Springs and Montecito, California.

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The idea that we can live however we want and then rely on a magic treatment for cognitive issues is unrealistic and dangerous. The reality is that our daily choices profoundly impact our brain’s future, and once cognitive decline begins, there is no clear-cut pharmaceutical solution.

I had the pleasure of speaking with Dr. Dale Bredesen, whose book The Ageless Brain is an incredible resource for protecting brain health. He has pioneered a comprehensive approach to preventing and even reversing cognitive decline. This book offers a powerful blueprint not only for sharpening your mind but also for building resilience against neurodegenerative diseases.

In The Ageless Brain, Dr. Bredesen distills decades of research into actionable steps. He explores key lifestyle factors—nutrition, sleep, exercise, stress management, and supplementation—that influence cognitive performance and long-term brain resilience. What’s exciting is his proactive, personalized approach. Rather than waiting for symptoms to appear, Dr. Bredesen shows us how to build a brain that resists aging from the start.

Today, we’ll unpack some of the most impactful strategies from his book, discuss major breakthroughs in neuroscience, and explore how we can all take charge of our cognitive health. If you’ve ever wondered what it takes to maintain lifelong clarity and vitality, you won’t want to miss this conversation.

Dale Bredesen, MD, is an internationally recognized neurologist specializing in neurodegenerative diseases. He is the Senior Director of Precision Brain Health at Pacific Neuroscience Institute® and the Chief Scientific Officer at Apollo Health.

Guided by his belief that Alzheimer’s is not just preventable but reversible, Dr. Bredesen’s groundbreaking research has helped explain the biological mechanisms behind memory loss. His decades of study have led to new treatment approaches, including the ReCODE Protocol™—also known as the Bredesen Protocol—a strategy designed to prevent, slow, and even reverse cognitive decline associated with Alzheimer’s, dementia, and mild cognitive impairment.

Timestamps:
0:00 Introduction to Guest

2:48 Phase 3 Trial Upcoming

10:11 Alzheimer’s: Different Triggers, Different Outcomes

13:11 Could Brushing Your Teeth Save Your Brain? (Oral Microbiome & Alzheimer’s

18:45 The 3 Major Players in Brain Health

22:24 How to Make Sure You Never Get Dementia

22:33 Blood Markers for Alzheimer’s: What Your Tests Reveal

28:10 Diabetes and Alzheimer’s: The Hidden Connection

34:18 The #1 Contributor to Cognitive Decline: Insulin Resistance

39:54 How to Match Your Brainspan to Your Lifespan

40:31 Top Supplements for Brain Health

43:15 The Power of Nitric Oxide for Your Brain

48:07 Leaky Gut & Cognitive Decline

54:15 Metformin & Brain Longevity

57:31 Why Do More Men Than Women Get Parkinson’s

1:05:24 ADHD & Alzheimer’s: The Fruit Fly Discovery ("Alzflymers")

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Dale Bredesen, M.D., is an expert in neurodegenerative diseases such as Alzheimer’s. He is a graduate of Caltech and received his MD from Duke University Medical Center. His career includes serving as Chief Resident in Neurology at UCSF, working as an NIH Postdoctoral Fellow, and holding faculty positions at UCSF, UCLA, and UC San Diego. He was the director of the Program on Aging at the Burnham Institute and the founding President and CEO of the Buck Institute. His work has led to a new therapeutic approach for treating Alzheimer’s. He is the author of The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline.

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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Over the last several decades, it’s been interesting to watch the progression of ideas for treating Alzheimer’s change from focusing on brain chemistry to targeting the accumulation of proteins in the brain associated with the disease. Recently, there’s been exciting interest in studying how the brain’s electrical circuits and rhythms change in Alzheimer’s and other brain degenerative disorders.The human brain operates in rhythms, with gamma frequencies playing a critical role in cognitive functions such as memory, attention, and learning. In neurodegenerative diseases like Alzheimer’s, these gamma oscillations are disrupted, contributing to the accumulation of harmful proteins such as amyloid-beta and tau. Cognito Therapeutics has developed a pioneering approach using non-invasive light and sound stimulation to restore these rhythms and trigger natural mechanisms for clearing these toxic proteins.In preclinical and early clinical trials, this method has demonstrated remarkable potential. By stimulating gamma oscillations, the therapy has shown the ability to reduce inflammation, enhance synaptic function, and activate microglia—immune cells responsible for clearing debris and maintaining brain health. For families battling cognitive decline, these results offer hope for improving quality of life and potentially slowing disease progression. Cognito’s research focuses on safety, accessibility, and scalability. Unlike pharmaceutical interventions, this approach avoids invasive procedures or systemic side effects, making it an attractive alternative or complementary treatment for Alzheimer’s.As the company advances its clinical trials, the implications extend far beyond Alzheimer’s. Cognito’s technology could pave the way for treatments for neurological conditions like Parkinson’s, MS, and traumatic brain injury.On our podcast today, we are joined by Christian Howell, CEO of Cognito Therapeutics. Howell is committed to advancing the understanding of brain health and delivering groundbreaking therapeutic solutions to improve patient outcomes. Under his leadership, Cognito Therapeutics has made significant strides in the development of gamma-frequency neuromodulation technologies, leveraging light and sound stimulation to address the mechanisms of Alzheimer’s and other neurodegenerative disorders. Howell is a strong advocate for translating cutting-edge research into real-world applications and has spearheaded the company’s efforts to validate its therapies through rigorous scientific studies and clinical trials.Howell holds advanced degrees in neuroscience and bioengineering and has dedicated his career to bridging the gap between scientific discovery and patient care. His work reflects a commitment to improving the lives of individuals and families impacted by cognitive decline and to shaping the future of brain health through innovation and collaboration.====00:00 Introduction00:59 Optogenetic Light & SoundTherapy 11:28 Innovations in Light and Sound Therapy at 40Hz Interval; Generating Neuroplasticity17:48 Rethinking Alzheimer’s Treatment and Gamma Wave Stimulation’s Impact on Proteins20:43 Overview of Cognito Therapeutics at Home Device25:30 Usage for Therapeutic, Preventative, and Performance Enhancement. 28:37 Disease States: Dysregulation of Microglia; Long Covid, Chemo Brain, Sepsis 30:45: Breakthrough Designation from FDA For the Device38:07 FDA Approval, Distribution, and Insurance Approval; Economic Burdens of Alzheimer’s 44:30 Closing Insights on Revolutionary Therapies====Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

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There’s certainly a lot of interest these days in the idea of having a “total body MRI scan.” And with good reason. This turns out to be a highly sensitive study as it relates to detecting a variety of issues, even including early cancers.

I wanted to learn more about this technique so I traveled to Vancouver, Canada to meet with Dr. Raj Attariwala, developer of the Prenuvo Scan, a popular total body MRI here in America and the scan that I myself underwent.

In this interview we explore the need and utility of total body MRI, its limitations, what the future will likely bring in this area of imaging, as well as Dr. Attariwala’s more recent research dealing with metabolic imaging of the brain.

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0:00 Intro 

2:46 How & Why MRIs Work

7:37 Effectiveness for Early Detection

13:13 Cost/ Benefit Ratio of MRI

16:49 The Future of MRI & Metabolic Signature

21:27 Brain Health & Body Mass: Findings From Total Body MRI

27:20 Pushbacks on this Protocol

31:27 Total Body vs Regional MRI

34:00 Who Can't Have an MRI

36:00 Standardization in Interpretation of Scans

45:32 Success Stories

47:25 Detecting Colon Cancer

48:29 Best Protocol for Cancer Detection

51:53 Conclusion

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Dr Rajpaul Attariwala, M.D., PhD, FRCPC

Nuclear Medicine Radiologist & Biomedical Engineer

Dr Attariwala holds a doctorate in Biomedical Engineering from Northwestern University (Evanston, IL) prior to becoming a double board-certified radiologist and nuclear medicine physician certified in both Canada and USA. He received his formal training at UBC, along with specialized training at Memorial Sloan Kettering Cancer Centre (New York), UCLA, and USC. He is the creator of the Prenuvo scan and report which were developed at his MRI facility, AIM Medical Imaging in Vancouver Canada. His passion is to create and advance technology to help patients understand how their body changes in both health and disease. Currently he is working to develop and implement critical tools to promote healthspan in Medicine 3.0 with leading scientists and physicians from around the world. 

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That various microbes in the digestive system affect our health is certainly not news. However, this discussion is typically in the context of the various microbes that live in the gut. Actually, we technically need to begin this understanding at the level of the mouth. And, unfortunately, the idea that our oral microbes are influencing our health has not really gotten a lot of attention. As it turns out the state of health, diversity and function of the microbes living within the mouth are highly influential in terms of our ability to resist disease and remain healthy. Recently, there's been a lot research relating the oral microbiome to such maladies as coronary artery disease and even Alzheimer's disease itself. This will just one of many fascinating topics in my discussion today with Dr. Mark Burhenne.

So please enjoy the podcast. I suspect you will want to floss afterwards.

0:00 Intro

0:41 Oral Microbiome

10:30 Alzheimers the Oral Microbiome

21:59 Plaque is Necessary 

25:50 Benefits of Mouth Bacteria

35:14 Good Toothpaste

44:54 Flouride

56:30 Finding a Dentist

1:01:13 Conclusion

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Dr. Burhenne is a bestselling author and a family and sleep medicine dentist who has been in private practice nearly 35 years, he has focused on patient-centered and preventative dental healthcare. He is a TEDx speaker and his advice regularly appears on media outlets such as CNN, NPR, The Huffington Post, Prevention, Men's Health, CBS, and MindBodyGreen. He is the creator of AsktheDentist.com, is dedicated to exploring the mouth-body connection and the role of the oral microbiome not only its role in oral health, but in overall heath. Most recently, he has been advising an oral microbiome testing company (Bristle) to help establish the importance of the oral microbiome in health. Dr.B’s mission, by becoming a healthcare influencer, has been to illustrate to patients as well as providers that optimal health can not be achieved by ignoring oral health. New ways to look at oral health, and how it is connected to systemic health.

Molecular mechanism of fluoride’s effect on brain

https://www.sciencedirect.com/science/article/pii/S2352304222002495#bib83

Tongue scraping study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406172/

Physicians CRP letter

(explanation of how to use)https://askthedentist.com/crp-oral-health/

(printable version)https://askthedentist.com/wp-content/uploads/2015/04/dental-crp-contribution-letter-1.pdf

Bristle Test link https://www.bristlehealth.com/?oid=10&affid=6&%23038;_ef_transaction_id=81e0c47772f042599e3dc8e50b1e9bfc&%23038;utm_source=Ask+the+Dentist

CE course for our functional provider list:

https://www.youtube.com/watch?v=UgLSzAOBfNU

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Melatonin has taken center-stage in terms of interest from both the scientific community as well as the general population. And there are really good reasons for all this attention. Recently, with the Covid pandemic, melatonin has been looked upon as a way of "boosting the immune system." We've looked at melatonin for many years as a sleep aid and as a way of dealing with jet lag. We know that melatonin has antioxidant properties and even anti-inflammatory activity as well.

But, all of these ideas and information are ultimately confusing, to say the least. That's why today we're spending time with my good for friend, Dr. Deanna Minich, who has recently authored a terrific paper on this fascinating but confusing subject.. We talk about this paper, why she became interested in this fascinating molecule found in animals as well as plants,, and most importantly, what we can all do to benefit from this exciting new research on our Empowering Neurologist interview.

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0:00 Intro

2:47 Why Melatonin?

4:16 Plant Melatonin

5:45 How the body produces melatonin 

9:18 Vitamin D vs Melatonin 

12:50 Anti-inflammatory Activity 

15:30 Aging & Mitochondria Decline

26:03 Supplementing

35:02 Melatonin Binding to Vitamin D

37:09 Darkness Deficiency 

46:06 Conclusion

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Deanna Minich, MS, PhD, CNS, Certified Functional Medicine Practitioner (IFMCP), is a nutrition scientist, international lecturer, teacher, and author, with over twenty years of experience in academia and in the food and dietary supplement industries. Throughout the years, she has been active as a functional medicine clinician in clinical trials and in her own practice (Food & Spirit™), which has now become oriented towards groups, workshops, and retreats. She is the author of six consumer books on wellness topics, four book chapters, and fifty scientific publications. Her academic background is in nutrition science, including a Master of Science (M.S.) degree in Human Nutrition and Dietetics from the University of Illinois at Chicago (1995) and a Doctorate (Ph.D.) in Medical Sciences (nutrition focus) from the University of Groningen in the Netherlands (1999). For a decade, she was part of the research team led by the “father of Functional Medicine,” Dr. Jeffrey Bland, and has served on the Nutrition Advisory Board for The Institute of Functional Medicine, as well as on the Board of Directors for the American Nutrition Association. Since 2013, she has been part of the faculty for the Advanced Practice Module in Environmental Health offered by the Institute for Functional Medicine and has been teaching a graduate level course in metabolic detoxification at the University of Western States. Over the decades, she has taught thousands of nutrition classes for health coaches, fitness trainers, and healthcare professionals, including for programs offered by the Functional Medicine Coaching Academy and the Institute for Integrative Nutrition. In conjunction with her academic degrees and extensive teaching experience at the university level, she is both a Fellow (FACN) and a Certified Nutrition Specialist (CNS) through the American College of Nutrition. She is Chief Science Officer at Symphony Natural Health, where she leads the medical advisory team, oversees scientific communication, and provide educational leadership for the company’s plant-derived nutraceuticals. She is passionate about helping others to live well using therapeutic lifestyle changes that impact their physical, emotional, mental, and spiritual health. 

Visit her at: www.deannaminich.com

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Tune in to The Empowering Neurologist Podcast for an Inspiring Conversation with Dr. Jill Carnahan, Author of Unexpected

I’ve just finished recording a very moving interview with Dr. Jill Carnahan—Functional Medicine expert, speaker, and author. This was an unforgettable conversation about her new book, Unexpected. Dr. Carnahan’s story is one of resilience, empathy, and transformation, and her insights have changed countless lives through her compassionate approach to health.

Dr. Carnahan’s journey to becoming a functional medicine leader is anything but conventional. Early in her career, she faced serious health challenges that nearly ended her life and forever transformed her approach to patient care. After being diagnosed with breast cancer at just 25, Dr. Carnahan was forced to confront the fear, uncertainty, and upheaval that accompany life-altering illness. During her treatment, she developed a deeper understanding of what her patients were experiencing, not only physically but also emotionally. Just as she was beginning to regain her health, she was diagnosed with Crohn’s disease, a severe autoimmune disorder that impacted her life for years.

These back-to-back health crises became defining moments for Dr. Carnahan. They pushed her to pursue holistic healing modalities, ultimately shifting her career path toward Functional Medicine. Through her own journey of recovery, she developed a unique perspective on health that goes beyond treating symptoms, instead focusing on addressing the root causes of illness and the interconnectedness of mind, body, and spirit.

In our time together Dr. Carnahan discusses:

☑️ The pivotal moments in her life that led her to Functional Medicine and reshaped her philosophy on health

☑️  How emotional resilience and compassion are critical components of healing

☑️  Practical strategies to detoxify, restore gut health, and promote holistic recovery

☑️  Insights into managing autoimmunity and chronic illness in a way that prioritizes the whole person

☑️  The role of mindset and self-compassion in transforming personal health challenges into opportunities for growth

My hope is that you will find our conversation to be an inspiring and enlightening experience. Her warmth, empathy, and expertise make her a true pioneer in Functional Medicine and a source of hope for anyone on their own health journey.

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00:11  Intro

01:09  Introduction to Dr. Jill

04:30  Dr. Jill’s Cancer Diagnosis

09:16  How She Learned To Trust Herself: Blending Intuition with Logic

11:54  The Illusion of Certainty & Embracing Fear

14:53  Returning to Medical School Post Chemo

20:12  Where Jill’s Cancer May Have Originated

24:24  The Diet That Helped Dr. Jill’s Crohn’s, Colitis, SIBO and SIFO Flare Ups

34:51  Dr. Jill’s Journey Into Functional Medicine as a Doctor

39:45  Dr, Perlmutter Shares His Patient’s Gluten-Free Experience

41:11 Using The Human Genome in Functional & Integrative  Medicine

50:00 How Personal Agency Impacts The Healing Process

51:50 Upstream From The Microbiome Is The Soil & Outro

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Dr. Jill Carnahan is Your Functional Medicine Expert® dually board certified in Family Medicine for 10 years and in Integrative Holistic Medicine. She is the founder and Medical Director of Flatiron Functional Medicine, a widely sought-after practice with a broad range of clinical services including functional medical consulting, chiropractic therapy, physical therapy, naturopathic medicine, acupuncture, and therapeutic massage.

Be sure to follow her @drjillcarnahan on Instagram.

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We are hearing so much these days about the benefit of a ketogenic diet. But while there may be benefits, it's not necessarily the easiest diet for everyone to engage. Further, staying in ketosis for an extended period of time may actually be associated with some fairly significant threats to our health.

Today I'm speaking with Dr. Steven Gundry about his new book, Unlocking the Keto Code. I have to admit that at first, I thought this was going to be another way of engaging the ketogenic diet. But I soon learned that what this book is actually focused on is first, unraveling why a ketogenic diet is beneficial, and secondly, after the reader understands the importance of the mechanisms underlying the ketogenic diet, it provides them the tools for bringing these mechanisms online without specifically going into ketosis.

That certainly sounds like a home run. The book focuses on the notion of "uncoupling mitochondria." This basically means that fuel is wasted as opposed to being utilized. It's a way of actually reducing the efficiency of mitochondrial function to bring about positive health benefits. I know this sounds challenging, and I agree that it is. Nonetheless, Dr. Gundry has done an exceptional job in terms of making this information clear and understandable. 

This is a wonderful new book and I believe it's certainly going to dramatically change the playing field moving forward as it brings to our attention not just the benefits of the ketogenic diet, but the value of things like cold exposure, heat exposure, consuming polyphenols, and a variety of other health supportive modalities

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TIMESTAMPS:

0:00 Intro

4:00 Unlocking the Keto Code

14:40 Achieving Keto without the Keto

27:07 7 Keys to Ketones

55:00 Conclusion

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Dr. Gundry is one of the world’s top cardiothoracic surgeons and a pioneer in nutrition, as well as medical director at The International Heart and Lung Institute Center for Restorative Medicine.  He is author of many New York times bestselling books including The Plant Paradox, and The Plant Paradox Cookbook, and The Longevity Paradox: How to Die Young at a Ripe Old Age and The Energy Paradox: What to Do When Your Get-Up-and-Go  Has Got Up and Gone. His new book Unlocking the Keto Code was recently published, and offers a new take on the keto diet that debunks common myths and shows readers how to reap the rewards of keto with less restriction. 

https://drgundry.com/

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What should we eat? I ask this question in the context of the incredible rates of obesity that we are now seeing, virtually worldwide. Today we will spend time with Dr. Jason Fung author of the book The Obesity Code. This is a landmark book that powerfully lays out why we are continuing to gain weight. It dispels the notion that dietary fat threatens to make us gain weight as well as the unfounded idea of calories in versus calories out as an explanation for why we gain weight.

Dr. Fung clearly focuses on the importance of the hormone, insulin, in terms of obesity, and certainly in terms of diabetes as well. He outlines a very straightforward plan that is in perfect alignment with current science. This interview is one of the most fundamental as a relates to the science of weight loss and regaining control over our blood sugar.

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0:00 Intro

2:36 Why Dr. Fung Pursued Weight Loss Research

8:08 Problem with Insulin 

15:15 Mechanisms of Insulin

23:09 Reconsidering Low Fat Diets & Calorie Counting 

37:34 Satiety Hormones

40:10 Leptin & Weight Loss

43:59 Threat of Fructose 

51:23 Conclusion

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Dr. Jason Fung is a Canadian nephrologist and a world-leading expert on intermittent fasting and low carb, especially for treating people with type 2 diabetes.

Dr. Fung graduated from the University of Toronto and completed his residency at the University of California, Los Angeles. He lives and works in Toronto, Canada.

Here is Dr. Fung’s website:

https://thefastingmethod.com/

https://www.dietdoctor.com/intermittent-fasting

https://www.dietdoctor.com/low-carb

https://www.dietdoctor.com/diabetes

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Researchers around the world are looking at the role of a mechanism, inflammation, in what makes a good brain go bad, and specifically in diseases like Alzheimer’s. Dr. Jack Auty is a Tasmanian researcher who is focused on this process and is exploring a variety of inroads to inflammation, including, zinc deficiency, as well as the possible role of our ever-increasing exposure to microplastics in amplifying this mechanism.

Dr. Auty has a very expansive social media exposure, bringing this information to the public awareness. He’s a very interesting researcher on a number of levels, including fieldwork looking at animals exposed to microplastics as well as translational research from the lab to humans again focused on inflammation and its damaging role throughout the body, and specifically the brain. 

Currently, Dr. Auty is a lecturer in the Medical Sciences division in the School of Medicine at the University of Tasmania. He, in addition, serves as a collaborator with an organization called the Adrift Lab, and we will learn more about their mission on our podcast as well.

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0:00 Intro

3:16 Studying the Mechanism of Inflammation

13:12 Optimizing Our Microglia

16:46 Polygenic Influences on Alzheimer’s

21:16 Accumulation of Microplastics 

34:35 Avoiding Microplastics

36:53 Zinc’s Impact on Alzheimer’s 

43:20 Removing the Blame From Lifestyle Choices

52:00 The Adrift Lab: Studying Microplastics

57:23 Conclusion

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Jack completed a Bachelor of Science in anatomy with a neuroscience focus at the southernmost university in the world – the University of Otago. During his degree Jack took several botany papers and fell in love with the subject, so Jack continued studies at Otago with a post graduate diploma in botany followed by a Ph.D. which combined botany and neuroscience by investigating the effects of marijuana-like synthetic cannabinoids on inflammation in the ischemic brain, combining botany and neuroscience.

After completing his Ph.D., Jack continued his research at the University of Otago with projects on hydrogen sulphide as an inflammatory signaling molecule and kamikaze neutrophils that release their DNA contents onto bacteria. He then moved to the University of Manchester, where he primarily investigated the role of the inflammasome in Alzheimer's disease and age-related cognitive decline. Jack was fortunate to have inspiring, supportive, and scientifically proficient supervisors and collaborators in Dr. Catherine Lawrence and Prof. David Brough, under whose guidance he was able to make significant contributions to the field of inflammation research.

Currently, Jack is a lecturer in Medical Sciences at the University of Tasmania, where he investigates inflammation. He is focused on establishing the inflammatory properties of environmental microplastics and identifying the cellular mechanisms that mediate microplastic-induced inflammation. Additionally, he aims to understand how peripheral and central inflammatory responses contribute to Alzheimer's disease.

https://jackauty.com

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In this episode of The Empowering Neurologist Podcast, we had the profound pleasure of reconnecting with my longtime friend and now filmmaker, Max Lugavere, the creative force behind the deeply moving documentary Little Empty Boxes. Max, who is as articulate as he is passionate, took us through the deeply personal journey that led to the making of his film—a narrative woven from love, loss, and the quest for understanding dementia.

The genesis of Little Empty Boxes is as poignant as it is inspiring. Max shared the moment his life changed during what was meant to be a serene summer vacation: his mother, Kathy, was unable to recall the current year, a lapse that signaled the onset of her cognitive decline. This incident wasn't just a fleeting moment of forgetfulness; it was the beginning of a challenging journey through the landscape of dementia, a condition affecting over 55 million people worldwide.

Moved by his mother's struggle, Max returned to New York City, transitioning from a concerned son to a determined researcher, diving deep into the complexities of dementia. The film follows his exploration of innovative approaches beyond conventional medication, aiming to slow the progression of his mother's illness.

Max described Little Empty Boxes as a project that "crept in, claws out." It wasn’t a film he planned, but one that emerged from necessity. His mother's worsening condition was harrowing to witness, but it birthed a purpose that transcended personal pain. Max emphasized that the film isn’t centered on definitive medical answers or miraculous recoveries. Instead, it presents a raw, messy, and intimately personal look into the life of a dementia patient and the daily realities of their caretakers.

One of the most touching moments in our conversation was Max’s reflection on the film as a tribute to his mother and a love letter to the science of dementia prevention. He hopes that by sharing his mother's story, the film will not only shine a light on ways to delay or prevent this devastating condition but also encourage viewers to cherish every memory. "It's about making the most of what remains, together," Max remarked, highlighting the film’s focus on the human elements of love, memory, and resilience.

Our discussion with Max was more than just an interview; it was an exploration of the emotional and scientific facets of dementia through the lens of a devoted son's experience. For anyone who has witnessed the impacts of dementia firsthand, or for those interested in the intersections of film and real-world issues, Little Empty Boxes offers a compelling narrative that is both educational and deeply moving.

Watch Little Empty Boxes here: https://littleemptyboxes.com/

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0:00 Intro

3:49 The Diagnosis That Changed Everything

8:09 How Medicine Failed Max’s Mom

12:07 How Fraudulent Research Clouded Our Knowledge

18:14 Making “Little Empty Boxes”

26:06 Bringing the Prevention Conversation to the Masses

35:50 Conclusion

====

Max Lugavere is a health and science journalist, filmmaker, and bestselling author. He is the author of the Genius trilogy of books, including the New York Times bestseller Genius Foods and the Wall Street Journal bestseller Genius Kitchen. He hosts The Genius Life podcast, one of the top health and wellness podcasts in the U.S, and has an audience of over 1.5 million followers across social media.

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What can we do to improve our brains? This is clearly a topic that is central to our messaging. And we have focused on a variety of levers to pull, including exercise, sleep, dietary changes, nature, connection, etc. But we've now learned about a powerful input that has proven incredibly effective in improving brain function, especially in a variety pathological situations like cognitive decline, anorexia, depression, and even autism. This innovative approach has been called olfactory enrichment. And basically, this involves stimulating the brain with various types of scents.

Perhaps the top researcher on the planet exploring this subject and creating innovative ways for us to take advantage of olfactory enrichment is Dr. Michael Leon.He received his PhD from the University of Chicago and joined the professoriate at the young age of 24. He is currently Professor emeritus in the Department of Neurobiology and Behavior at the University of California Irvine.

He has received the Research Scientist Development Award from the National Institute for Mental Health for his work on the neurobiology of early learning, the D.G. Marquis Award from the American Psychological Association for developing an effective treatment for children with autism, and the Healthcare Technology Acceleration Award from the California HealthCare Foundation for his work on body weight normalization. In a recent analysis from the Stanford University, he was ranked among the top 2% of scientists in the world.

On the podcast we review this empowering science in detail and I am certain you will be you captivated by the therapeutic potential of this intervention.Also, we’ll explore the device Dr. Leon has created so that everyone can take advantage of these exciting developments. 

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0:00 Intro

2:48 Researching Olfactory Enrichment 

7:25 Impact of Olfaction on Disease

13:47 Relationship Between Inflammation & Sense of Smell

16:27 Study of Olfactory & Memory Loss

19:41 Losing Sense of Smell In Covid

24:01 Relationship of Taste to Olfaction

26:04 Impact on Depression 

27:26 Difference Between this and Aromatherapy 

31:59 Treating Anorexia with This

33:11 How This Works on a Subconscious Level

34:50 Memory Air Device 

36:25 Conclusion

====

Michael Leon received his PhD from the University of Chicago and joined the professoriate at the age of 24.  He is currently Professor emeritus (recalled) in the Department of Neurobiology and Behavior at the University of California Irvine. He also is a member of the Center for the Neurobiology of Learning and Memory, as well as the Institute for Memory Impairments and Neurological Disorders at UCI.  He has received multiple awards for teaching undergraduates, including the Professor of the Year Award as the best teacher on the UCI campus. He has received the Research Scientist Development Award from the National Institute for Mental Health for his work on the neurobiology of early learning, the D.G. Marquis Award from the American Psychological Association for developing an effective treatment for children with autism, and the Healthcare Technology Acceleration Award, from the California HealthCare Foundation, Booz Allen Hamilton, and the Robert Wood Johnson Foundation for his work on body weight control. In a recent analysis from the Stanford University School of Medicine, he was ranked among the top 2% of scientists in the world for the impact of his research. He is a partner in Science Lab 3 and the Mando Group.

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Around 60 million people around the world have dementia. 300 million have depression, and billions of people are experiencing brain problems due to chronic stress. These conditions are partially preventable, but most people don’t know the steps to take to decrease their risk and protect their brains. It turns out that the place where our brains are at the highest risk for being damaged is actually in our homes, and that we have an incredible amount of control over what happens here. But sadly, most of us are being unintentionally exposed to things in our houses that are poisoning our brain health. In this episode, we’re going deep into the science that examines those factors in our environments that are damaging our brains. We connect with an expert in environmental and lifestyle medicine, Dr. Austin Perlmutter. We’re going to explore exactly what we are exposing ourselves to, in our homes, cars and offices, that threaten to worsen our cognitive and mental health. And, importantly, Dr. Perlmutter will reveal simple steps we can employ, today, to reduce this threat. 

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0:00 Intro

3:06 How our environment threatens our brain

8:18 Health Begins in the Kitchen

12:10 Air Pollution in the Kitchen

18:13 Pollution in our World Today

23:23 Hidden Sources of Pollution: Vacuums & Incense

28:34 Effectiveness of N95 Masks

31:00 We Can’t Overlook This

35:00 Air Fresheners & Perfumes 

39:13 Indoor Filtration & Ventilation 

46:40 Other Pollutants to Watch Out For

49:25 Conclusion

====

Here's more about our guest, and yes, my son:

Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, published researcher and international educator. His mission is to help people improve their health by targeting the biological basis of “stuckness” in our brains and bodies. His writings, presentations, podcasts, and online educational programs explore how environmental factors influence our cognitive and mental state and have reached millions. Dr. Perlmutter has been featured on PBS, Rolling Stone, MedPage today, Newsweek, Medical News Today, NPR and a wide range of other media outlets. He is a co-producer of the Alzheimer’s, the Science of Prevention series, and host of the Better Brain Blueprint series. Dr. Perlmutter currently serves as the managing director at Big Bold Health, a food-as-medicine company focused on helping people rejuvenate health through better immune function, where he is running a first-of-its kind study exploring the effects of plant nutrients on human aging through epigenetic modulation.

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What underlies the war on fat? It’s big business, wanting us all to eat more refined carbs and sugar to replace the fat calories that we’ve been instructed to reduce. And I can think of no one who has done more to open our eyes to this ongoing travesty than Nina Teicholz. Here’s more about her from her website:

Nina Teicholz is an investigative science journalist and leader in nutrition reporting who is challenging the conventional wisdom on dietary fat–particularly, whether saturated fat causes heart disease and whether fat really makes you fat. The New York Times bestselling author of The Big Fat Surprise. Teicholz also serves as Executive Director of The Nutrition Coalition, an independent non-profit group that promotes evidence-based nutrition policy. She is one of a new generation of researchers arguing that diets lower in carbohydrates are a scientifically sound approach for reversing nutrition-related diseases.

For more than half a century, we’ve been told to eat a diet high in grains, low in fat, saturated fat (and cholesterol), but the last two decades of research have led a growing number of scientists  to conclude that this diet, despite being rigorously tested, could never be shown to prevent any kind of disease.

Teicholz’s work also explains why this diet has remained official policy for so long: the roles played by crusading scientists, the food industry, and more.

The story is as much about politics as it is about science, and Nina Teicholz’s research ultimately confirms that the traditional foods we were told to abandon (meat, cheese, eggs, butter) are safe, and even good for health.

Nina Teicholz has been called “The Rachel Carson of the nutrition movement.” Her book has been called a “must read” by some of the most prestigious medical journals in the world, including The Lancet, The BMJ, and the American Journal of Clinical Nutrition.

In speaking about Nina, the immediate past-president of the World Heart Federation, said at the Davos Cardiology Update Davos (2017) “She shook up the nutrition world, but she was right.”

Please enjoy this compelling interview with one of my personal heroes.

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TIMESTAMPS:

0:00 Intro

3:30 Contradictions in the Plant-based movement

10:02 Who funds the Food Pyramid

15:59 The Carbs & Fats Debate

22:36 Debunking Keto Myths

27:07 Debating Dr. David Katz

33:37 Answering Keto Questions 

40:03 White House Conference on Nutrition

48:08 Conclusion

====

Nina Teicholz is a science journalist and author of the New York Times bestseller, The Big Fat Surprise, which upended the conventional wisdom on dietary fat–especially saturated fat and seed oils. Teicholz is also the founder of the Nutrition Coalition, a nonprofit working to ensure that nutrition policy reflects the best and most current science. Teicholz has appeared on most major TV networks, and her work has been published in the New York Times, Wall Street Journal, the Economist, as well as in academic journals including The BMJ and the journal of the National Academy of Sciences. She is a graduate of Stanford and Oxford Universities and is now author of the “Unsettled Science” column hosted on Substack.

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Alzheimer’s disease can be reversed. Need I state that again? That is the subject of our podcast featuring an interview with Dr. Heather Sandison. Dr. Sandison is a renowned naturopathic doctor and a leading expert in neurodegenerative diseases. She has dedicated her career to understanding and reversing cognitive decline, with a particular focus on Alzheimer's disease.

In this episode, we will be discussing her groundbreaking new book, Reversing Alzheimer's. This transformative work offers a comprehensive approach to preventing and reversing Alzheimer’s disease through personalized medicine, lifestyle changes, and cutting-edge therapies. Dr. Sandison’s insights provide hope and practical strategies for those affected by this devastating condition.

Tune in as we explore the innovative methods outlined in her book, the latest research in brain health, and how you can take proactive steps to maintain cognitive function. Whether you’re a caregiver, a healthcare professional, or someone concerned about your brain health, this episode is packed with invaluable information and inspiration.

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0:00 Intro

2:49 Promising Alzheimer’s Breakthrough

7:57 Where We’re Getting it Wrong with Alzheimer’s Prevention

11:00 Solving the Complex Problem of Alzheimer’s 

13:33 How Infections & Covid 19 Plays a Role

18:34 A Different View of Beta Amyloid

22:10 Studying the Treatment Plan 

26:50 Contrast Oxygen Therapy

33:21 Praise for Dale Bredesen’s Work

35:15 Conclusion

====

Dr. Heather Sandison, a distinguished naturopathic doctor, has devoted her career to providing compassionate care and innovative solutions to those affected by dementia. Renowned for her pioneering work, Dr. Sandison has integrated groundbreaking, holistic, and multimodal interventions, seamlessly creating clinical, residential, research, and educational platforms. Her relentless dedication has not only transformed the lives of patients and caregivers she has also set new standards in the field of dementia care. She is the author of Reversing Alzheimer's: The New Toolkit to Improve Cognition and Protect Brain Health, out with HarperCollins June 11th, 2024.

Learn more about brain health by signing up for our mailing list at:

drheathersandison.com

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We've had so many discussions that's far about the importance of dietary fat for health and longevity. But to be clear, the type of fat we consume is of incredible importance. These days our diets seem to be loaded with vegetable oils and seed oils, and as we will learn, these are generally quite threatening to our health. In fact vegetable oils are only recently introduced into human nutrition with global production increasing 1600% since the early 1900s.

There is a strong correlation between the increase consumption of vegetable oils and seed the oils with the incidence of severe chronic diseases including cardiovascular disease, diabetes and even various neurological conditions. 

Today we are going to explore a new type of oil called cultured oil, prepared by fermentation and subsequent filtration. Leading this industry is a company called Zero Acres Farms, and as such, I have reach doubt to its co-founder and CEO, Jeff Nobbs, to explore exactly what this company is doing as well as the health benefits of their product.

====

TIMESTAMPS: 

0:00 Intro

2:28 Realizing the Danger of Omega 6

10:10 Low Fat Diets

12:35 HNE

17:00 Inflammation & Lanolin Acid

20:38 Environmental Impact of Seed Oils

24:00 Saturated Fat

28:15 New Way to Produce Oils

33:36 What to Look for while buying

39:02 Conclusion

====

Jeff Nobbs: 

Jeff Nobbs is the co-founder and CEO of Zero Acre Farms, a food company replacing destructive vegetable oils with healthier, more sustainable oils and fats made by fermentation. Prior to Zero Acre Farms, Jeff also co-founded the fast casual restaurant chain Kitava, food security non-profit HelpKitchen, and rewards shopping platform Extrabux. He has also served as COO for Perfect Keto and General Manager of Rakuten after it acquired Extrabux. Jeff blogs about health, nutrition, and sustainability at jeffnobbs.com

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One of the most important levers we can pull as it relates to improving our brain function currently as well as paving the way for a healthier brain in the years to come is choose to eat foods that nurture the brain. My guest today on the Empowering Neurologist, Max Lugavere, has been deeply involved in exploring food as brain medicine for many years. Let me tell you a little bit more about him.

Max Lugavere is a filmmaker, health and science journalist and the author of the New York Times best-seller Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life, published in 8 languages around the globe. He is also the host of the #1 iTunes health podcast The Genius Life.

Lugavere appears regularly on nationally syndicated programs Rachael Ray Show, and The Doctors. He has contributed to Medscape, Vice, Fast Company, CNN, and the Daily Beast, has been featured on NBC Nightly News, The Today Show, and in The New York Times and People Magazine. He is an internationally sought-after speaker and has given talks at South by Southwest, TEDx, the New York Academy of Sciences, the Biohacker Summit in Stockholm, Sweden, and many others.

Max is a thought leader and citizen scientist doing a terrific job exploring how lifestyle choices play out in terms of charting the brain’s destiny. And today we discuss his wonderful new book, The Genius Kitchen.

====

0:00 Intro

3:50 Max’s Journey to Brain Health

11:10 Foods that Support the Brain

20:30 Foods & Satiation

30:33 Sodium

37:44 Eggs: A Cognitive Multivitamin

43:05 Prescribing Diet & Exercise 

59:00 Conclusion

====

Max Lugavere is a filmmaker, health and science journalist and the author of the New York Times best-seller Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life, published in 8 languages around the globe. He is also the host of the #1 iTunes health podcast The Genius Life.

Lugavere appears regularly on the Dr. Oz Show, the Rachael Ray Show, and The Doctors. He has contributed to Medscape, Vice, Fast Company, CNN, and the Daily Beast, has been featured on NBC Nightly News, The Today Show, and in The New York Times and People Magazine. He is an internationally sought-after speaker and has given talks at South by Southwest, TEDx, the New York Academy of Sciences, the Biohacker Summit in Stockholm, Sweden, and many others.

https://geniuskitchenbook.com/

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Get a special sneak peek of Calm Your Mind with Food here if you join Dr. Uma’s weekly email list: https://umanaidoomd.com/pages/calmyourmindwithfoodsneakpeek

Want even more? Get a special introduction to Nutritional Psychiatry for reducing anxiety and depression symptoms in a special 6-lesson mini-course from Dr. Uma, bundled with a copy of her book: https://umanaidoomd.com/products/calm-your-mind-with-food-anti-anxiety-course-book-bundle

====

Anxiety issues are certainly pervasive, and becoming much more common in our very stressful world. Generally, to go to therapy for dealing with anxiety seems to be pharmacotherapy, in other words, drugs. And while drugs may take the edge off and prove to be effective, it's good to know there are other ideas that are being considered. One important inroad into treating anxiety focuses on dietary change. We know that the consumption of the typical standard American diet is fraught with issues including posing a threat to metabolism by virtue of our consumption of large amount of ultra process foods which actually make up between 52 to 54% of of the calories consumed every day in American adults. This is a diet that has been associated with a dramatic increase risk for metabolic issues, cardiovascular disease, and even threatens the brain. As we will learn today, our consumption of these highly refined foods plays a role in creating anxiety as well.

Our guest today is Dr. Uma Naidoo, and we will be discussing her new book, Calm Your Mind with Food - A Revolutionary Guide to Controlling Your Anxiety.

Please enjoy the podcast.

====

0:00 Intro

3:42 The Rising Problem of Anxiety

6:37 Nutritional Psychiatry: Eating for Mental Health

9:51 Foods that Cause Anxiety

13:20 The Process of Healing Through Food

16:50 How We Can Gauge Progress

19:40 Helpful Lab Studies & Food Allergies

23:22 The Benefits of Supplements & Which to Take

28:04 Metabolic Issues & Anxiety

30:23 Bringing Medical Specialities Together

34:16 Starting Small and Regaining Control

37:35 Commonly Used Drugs that Impact Mood Disorders

39:33 Leptin Levels and Anxiety

42:13 The Future of Nutritional Psychiatry

45:20 Conclusion

====

Michelin-starred chef David Bouley described Dr. Uma Naidoo as the world’s first “triple threat” in the food and medicine space: a Harvard-trained psychiatrist, professional chef graduating with her culinary schools’ most coveted award, and a trained Nutrition Specialist. Her nexus of interests have found their niche in Nutritional Psychiatry.

Dr. Naidoo founded and directs the first hospital-based Nutritional Psychiatry Service in the United States. She is the Director of Nutritional and Lifestyle Psychiatry at Massachusetts General Hospital (MGH) & Director of Nutritional Psychiatry at MGH Academy while serving on the faculty at Harvard Medical School.

She is considered Harvard’s Mood Food Expert and has been featured in the Wall Street Journal, Goop, Live with Kelly & Ryan, and more. Dr. Naidoo is also the national bestselling author of This Is Your Brain on Food: https://umanaidoomd.com/collections/this-is-your-brain-on-food, and the upcoming title that we will discuss today, Calm Your Mind With Food https://umanaidoomd.com/collections/calm-your-mind-with-food

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Loneliness is pervasive in our modern world. The sense of isolation and lack of connection, clearly made worse by the COVID pandemic, is associated with a wide scope of health issues and even mortality. So what do we do?

Some important steps are presented in our podcast, an interview with the author of Project Unlonely - Healing Our Crisis of Disconnection, Dr. Jeremy Nobel.

Jeremy Nobel, M.D., MPH, is a primary-care physician, public health practitioner, and award-winning poet with faculty appointments at the Harvard T.H. Chan School of Public Health and the Harvard Medical School. He is the founder and president of the Foundation for Art & Healing (www.ArtandHealing.org), whose signature initiative, Project UnLonely, addressing the personal and public health challenges of loneliness and social isolation, has gained national visibility.

This is an important topic, not just for the elderly, living alone, but for all of us. For it is clear that any of us can feel lonely and disconnected, even in the midst of our busy lives.

====

TIMESTAMPS:

0:00 Intro

2:10 Our Epidemic of Loneliness

6:11 Leveraging the Creative Arts for Healing

12:21 Evaluating Loneliness in Studies

16:31 How Loneliness Equates to Heightened Disease Risk

19:43 The Loneliness Spiral

21:56 Inflammation

24:38 How World Events Impact Well-Being

26:45 What You Can Do: Art as a Medium for Healing

31:05 How Psychedelics Overlap with Creativity

35:44 Cultural Norms Impact Loneliness

38:31 The Biggest Challenge for Moving Forward

40:57 The Potential of Awe and Nature-Connection

44:24 Correlation Between Loneliness and FMRI Imaging

50:00 Conclusion

====

JEREMY NOBEL, M.D., MPH, is a primary-care physician, public health practitioner, and award-winning poet with faculty appointments at the Harvard T.H. Chan School of Public Health and the Harvard Medical School. He is the founder and president of the Foundation for Art & Healing (www.ArtandHealing.org), whose signature initiative, Project UnLonely, addressing the personal and public health challenges of loneliness and social isolation, has gained national visibility.

___________________________

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Who doesn't want to be happier? My good friend Dr. Daniel Amen, in his new book, You Happier, addresses that challenge and gives us meaningful actions to take, right now. Interestingly, Dr. Amen takes a personalized medicine approach to regaining happiness or  at least improving happiness as it were, by demonstrating that what can enhance our happiness is, to some degree, patient specific. Sure, there are the general recommendations with respect to our day-to-day lifestyle choices including nutrition, but Dr. Amen draws upon his vast experience over decades of interactions with patients as well as his evaluation of more than 200,000 brain scans to develop recommendations for individuals that can be even more helpful with respect to achieving a higher degree of satisfaction with life and overall happiness.

Again, the new book is, You Happier, and I think you're very much going to enjoy this interview.

====

TIMESTAMPS:

0:00 Intro

6:02 Happiness and the Brain 

8:09 Silencing the Noise in your Head

12:15 “More” Doesn’t make you Happier 

15:20 what makes for a happier brain 

26:41 Cultivating a happiness program

32:00 the Cerebellums impact 

36:30 Conclusion 

====

DR. DANIEL AMEN: 

Daniel G. Amen, MD, has helped millions of people change their brains and lives. He is the founder of Amen Clinics with nine locations across the United States, a 12-time New York Times bestselling author, and the cohost of The Brain Warrior’s Way Podcast, which he creates with his wife, Tana. He has produced 15 national public television specials about the brain that have aired more than 120,000 times across North America. Dr. Amen believes we can end mental illness by creating a revolution in brain health, and he regularly speaks to businesses, organizations, and churches about how to have a better brain and a better life. He has millions of loyal brain warrior followers on his social media accounts. 

SOCIAL

FB: https://www.facebook.com/drdanielamen

IG: https://www.instagram.com/doc_amen/

Twitter: https://twitter.com/DocAmen

Youtube: https://www.youtube.com/c/AmenClinic

NEW BOOK: You, Happier

https://danielamenmd.com/you-happier/

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Without question, a pivotal player in our health is the adequate and balanced functioning of the immune system. No matter what disease state you can consider, the immune system is playing an important role.

We now recognize that our metabolic health is hugely influential in determining the functionality of our immune system. As such, we know that our lifestyles influence metabolic health and therefore, with this understanding, we can influence immune function by paying attention to these decisions we make each day that are so influential as it relates to human metabolism.

On today's program, we are going to explore the concept of immune modulation and the relationship between immunity and metabolic health. We are also going to take a deep dive into new some very exciting discoveries as it relates to ancient foods that powerfully influence immune function including Himalayan tartary buckwheat, a modern day superfood that’s getting a lot of attention.

There couldn't be anyone better to walk us through this exciting new science than my longtime friend, Dr. Jeffrey Bland. 

This is a fascinating and thought provoking interview. To further explore this science, visit Big Bold Health: https://bigboldhealth.com/the-science

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0:00 Intro

4:25 The Immune System Connects Everything

13:27 Soil Health & Agricultural Toxins

19:01 Looking at the True Quality of Our Food

22:33 Discovering Himalayan Tartary Buckwheat

28:38 Polyphenols & Benefits of HTB

33:38 Longevity & Blue Zones

37:43 Forming a Super Superfood: Sprouting HTB

39:49 The True Interconnected Nature of the Body & Immune System

54:07 The Mystery of Ancient Medicine & Nature’s Intelligence

1:00:01 Taking a Closer Look at Functions

1:02:03 Conclusion

====

Jeff Bland, PhD is the founder of Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations — the immune system. Through Big Bold Health, Jeff is advocating for the power of Immuno-Rejuvenation to enhance immunity at a global level, often through the rediscovery of ancient food crops and superfoods. To get there, Jeff is building a network of small farms and suppliers throughout the US that take a clear stance on regenerative agriculture, environmental stewardship, and planetary health.

Jeff’s career in health spans more than 40 years. A nutritional biochemist by training, he began in academia as a university professor. Jeff then spent three decades in the natural products industry, working alongside other pioneers.

A lifelong educator, Jeff has traveled the world many times over in his role as the “father of functional medicine.” In 1991, he and his wife, Susan, founded The Institute for Functional Medicine. In 2012, Jeff founded another educational nonprofit called the Personalized Lifestyle Medicine Institute. Jeff is the author of The Disease Delusion: Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life, as well as countless additional books and research papers.

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We are so often told that one of our fundamental goals in life is to find our “passion” and follow it. If we can identify this goal, we are led to believe, then everything will magically fall into place.

According to Terri Trespicio, our guest on the podcast today, if we are busy looking for our passion we might well miss out on opportunities that may come our way. These opportunities may be related to our work or even our relationships. Terri makes it clear that it’s “OK not to know” as it relates to finding our passion, and that surpasses, if we are available for them, can be very fulfilling.

Many people seem to spend a great deal of time trying to figure out “what they are supposed to do.” But as Terri, quoting her mother counters, “You create life by living it.”

Reading Terri’s new book, UNfollow Your Passion, might well lead the reader to recognize that he or she is letting someone else set the rules for what is their life. And the book helps us understand both how this happens, and importantly, what we can do to put ourselves back in the driver’s seat.

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TIMESTAMPS:

0:00 Intro

2:10 Picking a Career Path

6:11 Romantic Partnership 

8:49 Comfort and Discomfort

18:38 The Things that we “Swallow”

23:14 Learning from MLMs

28:45 Tools for Redirection

40:25 Conclusion 

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Terri Trespicio is an award-winning writer, in-demand speaker, and brand advisor whose TEDx talk, “Stop Searching for Your Passion,” has been viewed more than seven million times. She earned her MFA in creative writing from Emerson College and won first place in the Baltimore Review’s 2016 literary contest. Her writing has also been featured in Marie Claire, Jezebel, Business Insider, and others. Visit TerriTrespicio.com for more information.

Instagram: @ttrespicio 

Twitter: @TerriT 

Facebook: @TerriTrespicio

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I'll never forget back in medical school that we were told that the brain was "terminally differentiated.” This means that brain cells were what they were, and could never be regenerated. As such, when a person had a stroke or brain injury, that was pretty much the end. There would be no improvement.

That understanding stands in stark contrast to what we have observed. Clearly, stroke patient can and do improve. And, it turns out, that this improvement can be enhanced with a type of therapy that applies pure oxygen under pressure to the patient. This increased oxygen in the brain does some wonderful things including, importantly, enhancing the growth of new brain cells. What a concept.

I have a long experience with hyperbaric oxygen therapy, having founded one of the countries largest hyperbaric centers. Much of the data upon which we relied came from researchers in Israel who were and continue to do cutting edge science demonstrating the profound effectiveness of hyperbaric oxygen therapy as it relates to stroke recovery. Nowadays, improvements in brain functionality can actually be visualized with state of the art brain imaging equipment.

Today, on the Empowering Neurologist, I have the great honor of interviewing Dr. Shai Efrati, one of the global leaders in the application of hyperbaric oxygen therapy for the treatment of stroke. Dr. Efrati is Founder and Director of the world-leading Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center, where he also serves as Director of Research and Development and Head of Nephrology. Dr. Efrati’s research focuses on novel aspects of hyperbaric medicine and brain rehabilitation. He is a professor at the Sackler School of Medicine and the Sagol School of Neuroscience in Tel Aviv University. Since 2008, he has served as Chairman of the Israeli Society for Diving and Hyperbaric Medicine.

Importantly, Dr. Efrati is now associated with the Aviv Clinic, which is not only offering hyperbaric oxygen therapy, but a far more comprehensive approach for stroke recovery And fortunately, the clinic is located in the Villages, just outside of Orlando Florida.

Please enjoy this fascinating deep dive into the benefits of hyperbaric oxygen therapy, especially as it relates to stroke recovery.

TIMESTAMPS:

0:00 Intro

1:21 Hyperbaric Oxygen Therapy

10:13 How Oxygen Therapy Works

14:37 Brain Cell Regeneration

16:43 Stroke Treatment

22:34 Scaling This Treatment

25:36 The Aviv Clinic

29:14 Vascular Dementia

35:43 Autism

40:39 Consult A Professional

42:33 Conclusion

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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱

In this episode of The Empowering Neurologist, we're diving into two topics that are gaining significant attention in the worlds of men's health and weight loss: the importance of testosterone replacement therapy and the emerging role of GLP-1 agonists in weight loss as well as in diabetes treatment. Joining us is an esteemed expert in this field, Dr. Tracy Gapin, a renowned urologist and men's health specialist.

Why is this topic so crucial? Testosterone, often hailed as the cornerstone of male vitality, plays a central role in various aspects of men's health. It's not just about physical strength or libido; testosterone impacts mood, energy levels, bone density, muscle mass, cognitive function, and overall well-being. However, as men age, testosterone levels naturally decline, leading to a condition known as hypogonadism or low testosterone. This decline can have profound effects on a man's health and quality of life.

Dr. Gapin, with his extensive experience and research in the field, sheds light on how testosterone replacement therapy can be a game-changer for men experiencing the effects of low testosterone. He delves into the nuances of identifying candidates for this therapy, the benefits, and the misconceptions surrounding it. His insights are particularly valuable in a time when discussions about men's hormonal health are often overshadowed or misunderstood. Further, as he explains, age-matched testosterone levels in men have plummeted over the past several decades, and we discuss why.

In addition, Dr. Gapin takes us through the exciting world of GLP-1 agonists, a class of drugs initially developed for diabetes management but now having a major impact in the weight loss arena. Obesity is a mounting concern globally, and its impact on men's health is undeniable. With cardiovascular disease, diabetes, and a host of other conditions linked to obesity, finding effective weight management solutions is paramount. Dr. Gapin explains how GLP-1 agonists work, their benefits, their potential risks, and their role in revolutionizing weight loss treatments.

This episode is not just for those directly experiencing these issues but also for anyone interested in the broader conversation about men's health. Whether you're a healthcare professional, someone exploring options for personal health improvement, or simply curious about the latest in medical advancements, Dr. Gapin's insights offer valuable knowledge and perspective.

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0:00 Intro

3:04 The Issues of Low Testosterone

7:07 Why Testosterone Levels are Falling

10:00 What Indicates Low Testosterone

15:00 The Holistic Approach to This

17:28 Why Testosterone Replacement Therapy May Be Essential

19:53 Addressing Potential Risks

28:20 How TRT Works & What to Expect

35:49 Looking at Estrogen and Progesterone 

37:23 LDL Medication and Low Testosterone

39:55 Addressing Thyroid Functionality

40:56 Honest Thoughts on Ozempic

50:28 Conclusion

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Tracy Gapin, MD, is a board-certified urologist, men’s health and performance expert. and founder of the Gapin Institute, a global leader in high performance medicine. He has over 20 years of experience focused on providing executives, entrepreneurs and athletes a personalized path to optimizing their health so they can have exceptional energy, laser-focused mind and a better body.

Text HEALTH to 26786 to receive an electronic copy of the High Performance Health Handbook for Men

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So-called "long Covid" is turning out to be a devastating condition for an incredibly large number of individuals around the world. It's been estimated that as many as 200 million people globally are suffering from this condition. And as many as 30 percent of Covid-19 survivors still experience symptoms long after their acute illness has passed, with cognitive and mental health problems especially prominent. 

From the publisher of Clearing the Fog: For long haulers, this struggle with Long Covid has irrevocably changed their lives. Many have lost their ability to work, attend school, and look after their children. They often feel misunderstood and dismissed by others. Their once-full lives are now filled only with doctors' appointments that seem more and more futile.

In Clearing the Fog, neuropsychologist Dr. James C. Jackson offers people suffering from Long Covid and their families a roadmap to help them manage their “new normal.” Focusing on cognitive impairment and mental health issues, he shows readers:

- The ways in which they can manifest and disrupt

- Suggestions for how and when to seek professional evaluations

- Science-based treatment options and strategies,

- Information on navigating health care systems and disability insurance

- Validation and hope as patients wrestle with their new diagnosis

In addition, Dr. Jackson shares his own experience with chronic illness, relating to long haulers with vulnerability and compassion.

Through moving stories as well as hands-on guidance, Clearing the Fog will help long haulers understand their current situation while offering multiple ways to address it, make sense of it, and move through it with the goal of thriving instead of merely surviving. 

In this interview with Dr. Jackson, we will explore the following questions, and a lot more:

What do we know about the cognitive and mental health consequences of Long Covid?

What areas of cognition are impacted in Long Covid survivors?

How does cognitive impairment impact the daily lives and the careers of those with Long Covid?

What treatments have you found effective for Long Covid survivors and what does the research say?

What do we know about the benefits of cognitive rehabilitation?

Are there ways to leverage the neuroplasticity that Long Covid survivors have?

What role does acceptance play in coping effectively with Long Covid

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TIMESTAMPS:

0:00 Intro

2:41 Cognitive Complaints

7:29 No Quick Fix

13:22 Cognition vs. Function Testing

17:58 The Ideal Long COVID Team

20:13 Plasticity and Recovery

22:40 Personalization in Treatment

25:08 Goal Management Training

29:16 Brain Training Apps

31:16 Anxiety and Depression

34:04 Restorative Sleep

35:39 Post Traumatic Growth

38:26 Practical Strategies

40:55 Conclusion

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