Neuro-Oncology: The Podcast (Neuro-Oncology)

Dr. Evan Noch interviews Drs. Nikhil Rammohan and Kathleen Bandt about their recent manuscript entitled "Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning", published online in Neuro-Oncology in February 2023.

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Dr. Iyad Alnahhas interviews Dr. Amanda Saratsis about her recent manuscript entitled: "H3K27M Mutant Glioma: Disease Definition and Biological Underpinnings", published online in Neuro-Oncology in October 2023.

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 Dr. Iyad Alnahhas interviews Dr. Alexander Hulsbergen about his and his team's recent manuscript entitled: "Neurosurgical resection for locally recurrent brain metastases", published online in Neuro-Oncology in July 2021.

Dr. Iyad Alnahhas interviews Dr. Danielle Bazer about her and her team's recently published manuscript, entitled: Using a Pre-Radiation Window to Identify Potentially Active Cytotoxic Agents in Adults with Newly Diagnosed Glioblastoma", published online in Neuro-Oncology in November 2024.

Dr. Maya Graham interviews Dr. Nduka Amankulor about the recent manuscript entitled: "Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles" published online in Neuro-Oncology in July 2021.

Dr. Iyad Alnahhas interviews Dr. Pim French about his and his team recent manuscript entitled: "Prognostic significance of genome-wide DNA methylation profiles within the randomised, phase 3, EORTC CATNON trial on non-1p19q deleted anaplastic glioma", published online in Neuro-Oncology in April 2021

Dr.Iyad Alnahhas interviews Drs. Andrea Gross and Brigitte Widemann about their manuscript entitled "Selumetinib in Children with Neurofibromatosis Type 1 and Asymptomatic Inoperable Plexiform Neurofibroma at Risk for Developing Tumor-Related Morbidity", published online in Neuro-Oncology in April 2022.

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Dr. Ankush Bhatia interviews Dr. Hussein Tawbi about his and his team's recent manuscript entitled "Safety and efficacy of the combination of nivolumab plus ipilimumab in patients with melanoma and asymptomatic or symptomatic brain metastases: Checkmate-204", published online in Neuro-Oncology in April 2021.

Dr. Jasmin Jo interviews Dr. Monika Hegi about her and her team's recent manuscript entitled: "No benefit from TMZ treatment in GB with truly unmethylated MGMT promoter: Reanalysis of the CE.6 and the pooled Nordic/NOA-08 trials in elderly GB patients", published online in Neuro-Oncology in (I will fill in through Libsyn)

Dr. Iyad Alnahhas interviews Dr. Mulki Mehari about her and her team's recent manuscript entitled: "Enhancing neuro-oncology care through equity-driven applications of artificial intelligence", published online in Neuro-Oncology in August 2024.

Dr. Ankush Bhatia interviews Dr. Emma van Kessel about her and her team's recent manuscript entitled "Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma", published online in Neuro-Oncology in February 2022.

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In this premiere episode, we will bring you some brief conversations with the current leaders of: The Society for Neuro-Oncology, the European Association of Neuro-Oncology, The Asian Society for Neuro-Oncology and the World Federation of Neuro-Oncology Societies

Dr. Evan Noch interviews Dr. Gunther Nussbaumer about his recent paper entitled: "Gliomatosis cerebri in children: a poor prognostic phenotype of diffuse gliomas with a distinct molecular profile" published online in Neuro-Oncology in May 2024.

 In this first of two episodes, Dr. Iyad Alnahhas interviews Drs. Ayal Aizer, Eudocia Lee and Veronica Chiang about the recent editorial review entitled: "Brain Metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions", published online in Neuro-Oncology in June 2022.

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Dr. Jasmin Jo interviews Dr. Leland Rogers about his and his team's recent manuscript entitled: "Low-risk meningioma: initial outcomes from NRG Oncology/RTOG 0539", published online in Neuro-Oncology in June 2022

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Dr. Iyad Alnahhas interviews Dr. Jona Hattangadi-Gluth and Ms. Mia Salans about their recently published manuscript entitled: "Longitudinal change in fine motor skills after brain radiotherapy and in vivo imaging biomarkers associated with decline" published online in February 2021 in Neuro-Oncology.

Dr. Rachna Malani interviews Dr. Hrishikesh Suresh about his and his team's recent manuscript entitled "Postoperative cerebellar mutism syndrome is an acquired Autism-like network disturbance", published online in Neuro-Oncology in December 2023.

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Dr. Iyad Alnahhas interviews Drs. Jennifer Cotter and Kee Kiat Yeo about their recent paper entitled: ""Multi-institutional study of the frequency, genomic landscape and outcome of IDH-mutant glioma in pediatrics", published online in Neuro-Oncology in May 2022.

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Dr. Evan Noch interviews Dr. Joanna Phillips about her and her team manuscript entitled: "PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications", published online in Neuro-Oncology in March 2022.

Dr. Jasmin Jo interviews Dr. Harry Pinson about his and his team's recent manuscript entitled: "Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era"

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Dr. Maya Graham interviews Drs. Mary Jane Lim-Fat and Kee Kiat Yeo about their recent manuscript entitled "A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients", published online in Neuro-Oncology in July 2024.

Link: https://doi.org/10.1093/neuonc/noae142

Dr. Jasmin Jo interviews Dr. Jason Sheehan about the recent manuscript entitled: "A Multicenter Matched Cohort Analysis of Incidental Meningioma Progression During Active Surveillance or After Active Stereotactic Radiosurgery: The IMPASSE Study", published online in Neuro-Oncology in June 2021.

Dr. Iyad Alnahhas interviews Dr. Raja Khan about their recent manuscript entitled "Clinical features, neurologic recovery, and risk factors of post-operative posterior fossa syndrome and delayed recovery: a prospective study", published online in April 2021 in Neuro-Oncology.

Dr. Iyad Alnahhas interviews Drs. Kelly Hotchkiss and Mustafa Khasraw about their recently published review entitled: "Dendritic cell vaccine trials in gliomas: untangling the lines", published online in Neuro-Oncology in June 2023.

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Dr. Iyad Alnahhas interviews Drs. Priya Kumthekar and Jeffrey Raizer about their recent manuscript entitled: A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2- positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics", published online in Neuro-Oncology in March 2023.

Dr. Alireza Mansouri interviews Dr. Matthew Dankner about his recent paper "Invasive growth associated with Cold-Inducible RNA-Binding Protein expression drives recurrence of surgically resected brain metastases" published online in Neuro-Oncology in January, 2021.

Dr. John Fortunato interviews Dr. Antonio Chiocca about his and his team's recent manuscript entitled "Lessons learned from phase 3 trials of immunotherapy for glioblastoma: time for longitudinal sampling?" published online in Neuro-Oncology in February 2024.

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Dr. Iyad Alnahhas interviews Drs. Simone Niclou and Anna Golebiewska about their recent manuscript, entitled: 'Cancer Cell Heterogeneity and Plasticity: A Paradigm Shift in Glioblastoma', published online in Neuro-Oncology in December 2021.

Description: Dr. Maya Graham interviews Dr. David Solomon about his and his team's recent manuscript entitled: "Prospective genomically-guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes", published online in Neuro-Oncology in April 2022.

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Dr. Maya Graham interviews Dr. Martin van den Bent about his and his team's recent review article entitled "The biological significance of age, enhancement, extent of resection and tumor grade in IDH mutant gliomas: how should they inform treatment decision in the era of IDH inhibitors? Invited review", published online in Neuro-Oncology in

Dr. Iyad Alnahhas, producer, introduces the new podcast.

Dr. Maya Graham interviews Drs. Josephine Hendriksen and Joachim Weischenfeldt about their recent manuscript, "Immunotherapy drives mesenchymal tumour cell state shift and TME immune response in glioblastoma patients," published online in Neuro-Oncology in May 2024.

Dr. Rachna Malani interviews Dr. Hervey-Jumper about his and his team's recent manuscript entitled "A population study of clinical trial accrual for women and minorities in neuro-oncology following the NIH revitalization act", published online in Neuro-Oncology in January 2022.

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Dr. Iyad Alnahhas interviews Dr. Kathreena Kurian about her and her team's recent manuscript entitled: "MGMT promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis based on a Cochrane Review", published online in Neuro-Oncology in April 2021.

Description: Dr. Maya Graham interviews Drs. Gaia Ninatti and Martina Sollini about their recent manuscript entitled: "Pre-operative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas", published online in Neuro-Oncology in September 2022.

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Dr. Nicholas Butowski interviews Drs. Sandro Santagata and Wenya Linda Bi about their recent manuscript entitled: "A molecularly integrated grade for meningioma", published online in Neuro-Oncology in September 2021.

Dr. Iyad Alnahhas interviews Drs. Justin Lathia and Marco Gallo about their recent manuscript entitled "Cancer stem cell hypothesis 2.0 in glioblastoma: where are we now and where are we going?", published online in Neuro-Oncology in May 2024.

Dr. Jasmin Jo interviews Dr. Caroline Chung about her paper: “A prospective phase II randomized trial of proton radiotherapy vs intensity modulated radiotherapy for patients with newly diagnosed GBM” published online in Neuro-Oncology in Feb 2021.

Description: Dr. Ankush Bhatia interviews Dr. Matthias Preusser about the recent letter in Neuro-Oncology, entitled: "What is an isocitrate dehydrogenase-mutated central nervous system World Health Organization grade 2 glioma, or who should receive vorasidenib?", published in July 2023.

Dr. Maya Graham interviews Drs. Benjamin Lin, David Nathanson, Frank Furnari and Ryan Miller about their recent manuscript entitled: "EGFR, the Lazarus target for precision oncology in glioblastoma", published online in Neuro-Oncology in September 2022.

Dr. Iyad Alnahhas interviews Dr. Ricardo Soffietti about the recent RANO review entitled "Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: a RANO review" published online in Neuro-Oncology in March 2024.

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Dr. Iyad Alnahhas interviews Dr. David Gutmann about the review entitled "T lymphocytes as dynamic regulators of glioma pathobiology", published online in Neuro-Oncology in March 2022.

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Description: Dr. Maya Graham interviews Dr. Lisbeth Marner about her recent manuscript "" Diagnostic accuracy and clinical impact of 18F FET PET in childhood CNS tumors" " published online in April 2021 in Neuro-Oncology.

Description: Dr. Maya Graham interviews Drs. Jasmin Jo, Craig Horbinski and David Schiff about their recent manuscript entitled: "Epidemiology, biology and management of venous thromboembolism in gliomas: an interdisciplinary review", published online in Neuro-Oncology in April 2023.

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Dr. Iyad Alnahhas interviews Dr. Carl Koschmann about his and his team's recent manuscript entitled: "Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma" published online in Neuro-Oncology in February 2022.

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Dr. Rachna Malani interviews Dr. Florian Scherer about his and his team's recent manuscript entitled: "Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas", published online in Neuro-Oncology in Sep 2023.

Link: https://pubmed.ncbi.nlm.nih.gov/37713267/

Description: Dr. Nicholas Butowski interviews Dr. David Reardon about his recent manuscript "Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results", published online in Neuro-Oncology in May 2021.

Dr. Maya Graham interviews Dr. Joseph Costello about his and his team's recent manuscript entitled "Whole tumor analysis reveals early origin of the TERT promoter mutation and intracellular heterogeneity in TERT expression", published online in Neuro-Oncology in December 2023.

Dr. Evan Noch interviews Dr. David Kaul about his and his team's recent manuscript entitled: "Adult intracranial ependymoma—relevance of DNA methylation profiling for diagnosis, prognosis, and treatment", published online in Neuro-Oncology in February 2023.

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Dr. Iyad Alnahhas talks with Dr. Felix Sahm about his recently published article in Neuro-Oncology entitled: "A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR," published online on November 1, 2020.

Dr. Evan Noch interviews Dr. Chunzhang Yang about his and his team's recent manuscript entitled "Abrogation of the G2/M checkpoint as a chemo sensitization approach for alkylating agents" published online in Neuro-Oncology in December 2023

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Dr. Iyad Alnahhas interviews Drs. Tobias Walbert and Johan Koekkoek about their recent manuscript entitled "Palliative care and end-of-life care in adults with malignant brain tumors", published online in Neuro-Oncology in October 2022

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Dr. Evan Noch interviews Dr. Mary Jane Lim-Fat about her and her team's recent manuscript entitled: "Clinical utility of targeted next generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making", published online in Neuro-Oncology in December 2021.

Dr. Evan Noch interviews Drs. Nathan Leclair, David Raleigh and Olga Anczukow about their recent manuscript entitled: "RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups", published online in Neuro-Oncology in August 2024.

Dr. Maya Graham interviews Drs. Benjamin Ellingston and Timothy Cloughesy about their recently published manuscript entitled: "Objective response rate (ORR) targets for recurrent glioblastoma clinical trials based on the historic association between ORR and median overall survival", published online in Neuro-Oncology in January 2023.

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 Dr. John Fortunato interviews Dr. Adrienne Boirre about her and her team's recent manuscript entitled "Leptomeningeal metastases from solid tumors: A SNO and ASCO consensus review on clinical management and future directions", published online in Neuro-Oncology on 

Dr. Evan Noch interviews Drs. Farshad Nassiri and Justin Wang from the team of Dr. Gelareh Zadeh about their recently published paper entitled “Loss of H3K27me3 in meningiomas” published online in Neuro-Oncology in May 2021.

Dr. Ankush Bhatia interviews Dr.François Ducray about his and his team's recent manuscript entitled:"Incidence and characteristics of pseudoprogression in IDH-mutant high-grade gliomas: A POLA network study", published online in Neuro-Oncology in March 2023.

Dr. Iyad Alnahhas interviews Dr. Gareth Evans about his recent paper in Neuro-Oncology entitled: "Disease course of Neurofibromatosis Type 2; a 30-year follow-up study of 353 patients seen at a single institution

Dr. Iyad Alnahhas interviews Drs. Maria Jose Contreras-Zarate and Diana Cittelly about their recent manuscript entitled: "Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis", published online in Neuro-Oncology in April 2023.

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Description: Dr. Maya Graham interviews Dr. Evan Noch about his and his team's recent manuscript entitled: "Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma", published online in Neuro-Oncology in July 2023.

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Dr. Evan Noch interviews Drs. Emma Phillips and Violaine Goidts about their recent manuscript entitled "A Novel Patient Stratification Strategy to Enhance the Therapeutic Efficacy of Dasatinib in Glioblastoma", published online in Neuro-Oncology in July 2021.

Dr. Evan Noch interviews Drs. Richard Drexler and Franz Ricklefs about their recent manuscript entitled: "DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients", published online in Neuro-Oncology in July 2022.

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Description: Dr. Ankush Bhatia interviews Drs. Julie Miller, Nicolas Gonzalez Castro, Samuel McBrayer and Patrick Wen about their recent manuscript, entitled: "Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions", published online in Neuro-Oncology in October 2022.

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Dr. Iyad Alnahhas interviews Drs. Sherise Ferguson and Michael Davies about their recent manuscript entitled: "Changes in Outcomes and Factors Associated with Survival in Melanoma Patients with Brain Metastases", published online in Neuro-Oncology in December 2022.

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Dr. Iyad Alnahhas interviews Drs. Vinay Puduvalli and Ying Yuan about their paper "A Bayesian adaptive randomized phase II multicenter trial of bevacizumab with or without vorinostat in adults with recurrent glioblastoma" published in Neuro-Oncology in March 2020

Dr. Evan Noch interviews Dr. Jill Barnholtz-Sloan about her recent paper "Epidemiology of Brainstem High-Grade Gliomas in Children and Adolescents in the United States, 2000-2017" published online in Neuro-Oncology in December 2020.

Description: Dr. Maya Graham interviews Dr. Carl Koschmann about his and his team's recent manuscript entitled: "Liquid biopsy in H3K27M diffuse midline glioma", published online in Neuro-Oncology in December 2023.

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Dr. Iyad Alnahhas interviews Dr. Katarzyna Jerzak about her recent paper “The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis”, published online in Neuro-Oncology in December, 2020. 

Dr. Evan Noch interviews Drs. Shannon Fortin Ensign and Sani Kizilbash about their recent paper in Neuro-Oncology entitled: "Translational significance of CDKN2A/B homozygous deletion in IDH mutant astrocytoma", published online in Neuro-Oncology in August 2022

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Dr. Ankush Bhatia interviews Dr. Keaton Piper about his and his team's manuscript, entitled "Consensus Review on Strategies to Improve Delivery Across the BBB Including Focused Ultrasound", published online in Neuro-Oncology in May 2024

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Dr. Iyad Alnahhas interviews Dr. Matthias Karajannis about his and his team's recent manuscript entitled: "Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult (AYA) brain tumor patients", published in Neuro-Oncology in February 2022

Dr. John Fortunato interviews Drs. Edward Avila and Steven Tobochnik about their recent manuscript entitled: "Brain tumor-related epilepsy management: A society for neuro-oncology consensus review on current management", published online in Neuro-Oncology in June 2023.

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Dr. Alireza Mansouri talks with Dr. Lorenzo Bello about his recently published article in Neuro-Oncology entitled: "Association of Supratotal Resection with Progression-Free Survival, Malignant Transformation, and Overall Survival in Lower-Grade Gliomas," published online on October 13, 2020.

Dr. Iyad Alnahhas interviews Drs. Thomas Zeyen and Johannes Weller about their recent manuscript entitled: "Quantitative assessment of residual tumor is a strong and independent predictor of survival in methylated glioblastoma following radiochemotherapy with CCNU/TMZ", published online in Neuro-Oncology in October 2024.

Dr. Iyad Alnahhas interviews Dr. Houton Noushmehr about his recent paper "A serum-based DNA methylation assay provides accurate detection of glioma", published online in Feb 2021 in Neuro-Oncology

Dr. Iyad Alnahhas interviews Dr. Philipp Karschnia about his and his team's recent manuscript entitled "Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group", published online in Neuro-Oncology in May 2023. 

Dr. Iyad Alnahhas interviews Dr. Matthias Preusser about the recent manuscript entitled: "Trabectedin for recurrent WHO grade 2 or 3 meningioma: a randomized phase 2 study of the EORTC Brain Tumor Group (EORTC-1320-BTG)", published online in Neuro-Oncology in October 2021.

Dr. Maya Graham interviews Drs. Ghazaleh Tabatabai and Felix Behling about their paper entitled “H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort” published online in Neuro-Oncology in December 2020.

Dr. Ankush Bhatia interviews Dr. Jack Grinband about his recent manuscript entitled "BOLD Asynchrony Elucidates Tumor Burden in IDH-Mutated Gliomas", published online in Neuro-Oncology in July 2021

Dr. Evan Noch interviews Dr. Elizabeth Claus about her recent manuscript entitled: "Environmental and sex-specific molecular signatures of glioma causation" published online in Neuro-Oncology in May 2021.

Dr. Evan Noch interviews Drs. Pravesh Gupta and Krishna Bhat about their recent manuscript entitled "Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas", published online in Neuro-Oncology in August 2024

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Dr. Iyad Alnahhas interviews Dr. Steven Tobochnik about his and his team's recent manuscript entitled "Glioma genetic profiles associated with electrophysiologic hyperexcitability", published online in Neuro-Oncology in Sep 2023.

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 Dr. Evan Noch interviews Drs. Kee Kiat Yeo and Matthias Karajannis about their recent manuscript entitled: "Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high grade glioma", published online in Neuro-Oncology in April 2022.

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Description: Dr. Jasmin Jo interviews Dr. Michael Lim about his and his team's recent manuscript entitled: "Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter", published online in Neuro-Oncology in November 2022.

Dr. Iyad Alnahhas interviews Dr. Craig Horbinski about his and his team's recent manuscript entitled "The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma", published online in Neuro-Oncology in December 2024.

Dr. Iyad Alnahhas interviews Dr. Nathalie Albert about her and her team's recent manuscript entitled: "Measurable disease as baseline criterion for response in glioblastoma: A comparison of PET-based (PET RANO 1.0) and MRI-based (RANO) assessments", published online in Neuro-Oncology in January 2025.

Dr. Iyad Alnahhas interviews Dr. Max Kros about his and his team's recent manuscript entitled: "Mitotic count is prognostic in IDH-mutant astrocytoma without homozygous deletion of CDKN2A/B. Results of consensus panel review of EORTC trials 26053 and EORTC 22033-26033", published online in Neuro-Oncology in December 2022.

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Dr. Iyad Alnahhas interviews Drs. Alice Morin, Samuel Abbou and Brice Fresneau about their recent manuscript entitled "Very long-term outcomes of pediatric patients treated for optic pathway gliomas: a longitudinal cohort study" published online in Neuro-Oncology in March 2024.

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Dr. Iyad Alnahhas interviews Dr. Linda Bi, Hia Ghosh and Ruchit Patel about their recent manuscript entitled: "Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4400 Tumors", published online in Neuro-Oncology in August 2024.

More Information:
https://academic.oup.com/neuro-oncology/advance-article/doi/10.1093/neuonc/noae164/7737688

Dr. Maya Graham interviews Dr. Nancy Ann Oberheim Bush about her and her team's paper entitled " Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas" published online in Neuro-Oncology in April 2021

Dr. Evan Noch interviews Drs. Frank Furnari and Jorge Benitez about their recent paper: "PTEN deficiency leads to proteosome addiction, a novel vulnerability in glioblastoma" published online in Neuro-Oncology in January, 2021.