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Dive into the complete episode list for Immune. Each episode is cataloged with detailed descriptions, making it easy to find and explore specific topics. Keep track of all episodes from your favorite podcast and never miss a moment of insightful content.

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Pub. DateTitleDuration
16 Mar 2018Immune 6: Potent antiviral antibodies without somatic mutation01:29:03

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph - REACTOME project (free icons)
Cindy - Gender Imbalance in Stories
Vincent - Trump, Tell Us About Your Flu Shot

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

13 Aug 2024Immune Booster #6: From Ghana to heat shock with Robert Binder00:27:29

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Robert Binder to talk about his career, the research of his laboratory on the role of heat shock proteins in cancer immunosurveillance, and the importance of inspiring students as early as possible to think about science.

Hosts: Cindy Leifer and Brianne Barker

Guest: Robert Binder

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Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

24 Mar 2021Immune 43: CAR-NK and CAR-MAC, thinking outside the CAR-T cell box01:18:53

On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

 

22 Feb 2018Immune 5: Mother knows best about food allergies01:40:57

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Music by Steve Neal. Immune logo image by Blausen Medical.

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16 Dec 2017Immune 3: Two epitopes, four serotypes, and a partridge in a pear tree01:19:15

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy - Questions answered about starving polar bear video
Steph
- Deep Work by Cal Newport and Grad Student Tax
Vincent - Making art with Excel

Music by Steve Neal. Immune logo image by Blausen Medical.

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19 Aug 2022Immune 59: Forks in the road: Th17 cells with Mandy McGeachy01:23:00

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be ‘good’ or ‘bad’ in their function.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Mandy McGeachy

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Music by Steve Neal.
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29 May 2019Immune 20: In defense of death01:28:11

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.

 

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Weekly Science Picks

Steph- iBiology Immunology Course
Cindy- Changing vaccine hesitancy
Vincent- Bad Advice by Paul Offit (and Vaccines and Your Child)

Listener Pick

Steve- An Elegant Defense

Music by Steve Neal. Immune logo image by Blausen Medical.

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26 Feb 2025Immune 89: Misplaced antibodies and foreign food foes01:22:50

Immune discusses how non-neutralizing antibodies can still be protective…intracellularly, and a technically innovative paper that uses Lipstic to label antigen-presenting cells responsible for gut tolerance to food antigens.

Hosts: Vincent RacanielloCindy LeiferSteph Langel, and Brianne Barker

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Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

 

 

25 Mar 2025Immune 90: Immunology of Injury00:53:22

Immune 90: Immunology of Injury

March 25, 2025

From the 2024 Society for Leukocyte Biology meeting at Michigan State University, home of the Spartans, Immune’s Cindy and Brianne talk with Liz Kovacs and Jim Lederer about their careers, dirty mice, old mice, and immunity during trauma.

Hosts: Cindy Leifer and Brianne Barker

Guests: James Lederer and Elizabeth Kovacs

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Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

03 Aug 2022Immune 58: Gut B cells awry in ulcerative colitis01:17:22

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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27 Mar 2019Immune 18: Biting off more TCR than you can chew01:20:35

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Scientists rise up against statistical significance
Cindy- Why I quit my PhD and returned
Vincent- The Law and Vaccine Resistance

Music by Steve Neal. Immune logo image by Blausen Medical.

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03 May 2023Immune 67: Can T cells live forever?01:15:32

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity.

Hosts: Vincent RacanielloCynthia LeiferSteph Langel, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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28 Nov 2020Immune 38: COVID-19 and kids with Sallie Permar01:10:57

Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2.

Guest: Sallie Permar

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

19 Sep 2019Immune 24: Unlucky IL-1301:29:23

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy- Lasker Award 2019
Vincent- Eleanor's Breakthrough video

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

26 Jul 2023Immune 70: Immunology of picky eating01:07:32

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses.

Hosts: Vincent RacanielloCynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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18 May 2023Immune 68: Sins and blessings of immunity01:07:42

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.

Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel

Download Immune 66 (45 MB .mp3, 76 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

20 Aug 2024Immune Booster #7: Emerging viruses with David Martinez00:23:46

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey.

Hosts: Cindy Leifer and Steph Langel

Guest: David Martinez

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Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

29 Jan 2025Immune 88: Bespoke antibodies and stinging erythropoiesis01:28:35

Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis.

Hosts: Vincent RacanielloCindy LeiferSteph Langel, and Brianne Barker

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Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

31 Mar 2020Immune 29: Immunology of COVID-1901:26:56

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

22 Dec 2021Immune 51: Teenage NINJA mice with Nikhil Joshi01:03:23

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Nikhil Joshi

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  • Creation of NINJA mice (Nature Biotech)
  • Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

23 Sep 2023Immune 72: After dark in the library with Ellen Rothenberg00:57:29

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Ellen Rothenberg

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Download Immune 72 (53 MB .mp3, 73 min)
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Music by Steve Neal.
Immune logo image by Blausen Medical

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25 Nov 2017Immune 2: Lymphocytes after dark01:26:55

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy - Men ask more questions than women at a scientific conference (PLoS One)
Steph
- House just voted to bankrupt graduate students
Vincent - Trump's Legacy: Damaged Brains

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

08 Nov 2022Immune 61: Training immune cells with Julia Bohannon and Musa Mhlanga01:04:23

From SLB22 on the Island of Hawai’i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests: Julia Bohannon and Musa Mhlanga

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Music by Steve Neal.
Immune logo image by Blausen Medical

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02 Dec 2022Immune 62: Every cell is an immune cell with De'Broski Herbert01:23:43

De’Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests D’Broski Herbert

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Music by Steve Neal.
Immune logo image by Blausen Medical

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24 Sep 2024Immune 84: Gender-affirming therapy and immune responses with Petter Brodin01:04:50

Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men).

Hosts: Vincent RacanielloCindy LeiferSteph Langel, and Brianne Barker

Guest: Petter Brodin

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Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

09 Jul 2024Immune Booster #2: Sex differences in immune responses with Michal Tal00:27:41

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Michal Tal to talk about her career, sex differences in immune responses, and how one giant mouse uterus changed the trajectory of her research career.

Hosts: Cindy Leifer and Brianne Barker

Guest: Michal Tal

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Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

09 Apr 2025Immune Booster #11 Immunity to Fungi with Amy Hise00:25:23

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Amy Hise about her career in science, her current research using mouse models for investigating fungal immunity and navigating the challenges of being a mom in science.

Hosts: Cindy Leifer and Brianne Barker

Guest: Amy Hise

Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

16 Jul 2024Immune Booster #3: NKT cells and cancer, and DEI in research with Tonya Webb00:29:01

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research.

Hosts: Cindy Leifer and Brianne Barker

Guest: Tonya Webb

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Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

19 Sep 2018Immune 12: Systems immunology01:11:39

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Kaleidoscopean
Cindy- 500 women scientists
Vincent- NIH budget increase 2019

Music by Steve Neal. Immune logo image by Blausen Medical.

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25 Aug 2020Immune 34: Coronavirus cross-reacting T cells01:26:59

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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01 Nov 2019Immune 25: Remembrance of antigen encounters past01:22:29

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Stephanie - This Week in Neuroscience
Cindy - Graduate Abuse by Derek Lowe
Vincent - Funding ends for seeking new viruses

Music by Steve Neal. Immune logo image by Blausen Medical.

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03 Sep 2024Immune Booster #8: Immunology, metabolism, and exercise physiology with Heather Caslin00:26:42

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease.

Hosts: Cindy Leifer and Brianne Barker

Guest: Heather Caslin

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Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

27 Aug 2024Immune 83: Immune cells eating other cells01:23:37

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness.

Hosts: Vincent RacanielloCindy Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

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11 Dec 2023Immune 74: Germinal center dynamics with Carla Nowosad01:11:19

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation.

Hosts: Stephanie LangelCynthia Leifer, and Brianne Barker

Guest: Carla R. Nowosad

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Music by Steve Neal.
Immune logo image by Blausen Medical

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08 May 2020Immune 31: Immunology of COVID-19, part three01:30:05

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical.

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01 Jun 2022Immune 56: Flip flops on the thymic beach with Al Singer01:15:00

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Al Singer

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Music by Steve Neal.
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27 Jul 2021Immune 46: Bats don't STING like a bee01:10:37

Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
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28 Nov 2019Immune 26: Measles erases immune memory01:37:33

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Michael Mina

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Music by Steve Neal. Immune logo image by Blausen Medical.

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22 Dec 2018Immune 15: Happy neu-trophil year01:26:27

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Should reviewers remain anonymous?
Cindy- Breast Cancer Research Foundation
Vincent- Initiative to End Paywalls (The Scientist)

Music by Steve Neal. Immune logo image by Blausen Medical.

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21 Oct 2020Immune 36: Aberrant immunity in COVID-1901:27:56

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Alexander Dent

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Music by Steve Neal.
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23 Sep 2020Immune 35: SARS-CoV-2 antibodies01:20:11

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
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03 May 2022Immune 55: Cells that suck at their job01:09:17

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Music by Steve Neal.
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18 Aug 2018Immune 11: Immunomimetic designer cells01:08:33

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections.

Hosts: Vincent Racaniello and Cynthia Leifer

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Science Picks

Cindy - No Tdap link to autism
Vincent
- Unpaywall

Music by Steve Neal. Immune logo image by Blausen Medical.

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14 Jan 2025Immune 87: When the immune system misbehaves01:09:25

Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus.

Hosts: Vincent RacanielloCindy LeiferSteph Langel, and Brianne Barker

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Music by Tatami.
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04 Apr 2023Immune 66: COVID-19 immune memory - what you need to know01:30:07

Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Music by Steve Neal.
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28 May 2024Immune 80: Intranasal neomycin; sex hormones and skin immunity; and maternal diet and infant microbiomes01:15:56

Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health.

Hosts: Stephanie LangelCynthia Leifer, and Brianne Barker

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Music by Steve Neal.
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26 Nov 2024Immune 86: Where did the SARS-CoV-2 antibodies go?01:05:13

Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination.

Hosts: Vincent RacanielloCindy LeiferSteph Langel, and Brianne Barker

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Music by Tatami.
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30 Jan 2024Immune 76: Macrophages to the rescue with Juliet Morrison01:07:07

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes.

Hosts: Vincent RacanielloSteph LangelCynthia Leifer, and Brianne Barker

Guest: Juliet Morrison

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Download Immune 76 (48 MB .mp3, 67 min)
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Music by Steve Neal
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01 Dec 2020Immune 39: A Tonka Truck full of salt01:23:38

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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13 Oct 2021Immune 49: I fell in love with worms with Keke Fairfax01:34:20

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Keke Fairfax

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15 Jun 2023Immune 69: Lung cancer and retroviruses01:09:50

Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer.

Hosts: Vincent RacanielloCynthia LeiferSteph Langel, and Brianne Barker

Guest: Kevin Ng

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12 Jun 2019Immune 21: Islets of Langelhans01:27:17

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Steph- Unique Scientists
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28 Jul 2020Immune 33: COVID-19 immunotypes01:23:57

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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30 Jul 2024Immune 82: Bat antibodies are hot01:14:58

Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight.

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14 Nov 2018Immune 14: Braking bad01:20:17

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Steph- Immunobites
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13 Sep 2021Immune 48: Environmental enteric dysfunction with Timothy Hand01:14:56

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Timothy Hand

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20 Jun 2018Immune 9: Neither mice nor lamprey lie01:35:11

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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17 Apr 2020Immune 30: Immunology of COVID-19, part two01:23:27

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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25 May 2018Immune 8: Staying warm with γδ T cells01:19:29

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Steph- Polycystic ovary syndrome and anti-Mullerian hormone
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22 Sep 2022Immune 60: Immunoeducation with Sumali Pandey and Phil Mixter01:41:50

Somali and Phil join Immune to discuss their approaches to immunology education.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Sumali Pandey and Phil Mixter

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20 Oct 2018Immune 13: Do no harm01:17:01

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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16 Nov 2020Immune 37: Black in Immuno02:00:55

Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guests: Alexis Mobley, Joel Babdor, Elaine Kouame, Justine Noel, Evonne Jean

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11 Nov 2021Immune 50: Red blood cells are immune sentinels01:21:25

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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11 Jan 2020Immune 27: Trained immunity01:33:55

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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27 Feb 2024Immune 77: Squeezing the most killing out of neutrophils00:56:58

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing.

Hosts: Vincent RacanielloSteph LangelCynthia Leifer, and Brianne Barker

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30 Dec 2020Immune 40: COVID-19 nuances01:35:18

Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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06 Aug 2024Immune Booster #5: Infections and the gut microbiome with Rafael Polidoro00:28:35

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections.

Hosts: Cindy Leifer and Steph Langel

Guest: Rafael Polidoro

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31 Oct 2017Immune 1: Some like it hot01:05:31

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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- Gammaherpesvirus protects against asthma
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20 Dec 2022Immune 63: Immune, promptly01:42:59

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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30 Jun 2022Immune 57: Bacteria, the new cure for wounds?01:27:40

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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18 Apr 2018Immune 7: Contradictory complements in Alzheimer's disease01:13:05

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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06 Apr 2022Immune 54: Asthma and aging01:28:04

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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17 Apr 2019Immune 19: Mom's the word01:16:33

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.

 

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24 Jan 2023Immune 64: A tangled web of wires01:50:11

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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13 Feb 2021Immune 42: Evolution of SARS-CoV-2 antibody immunity with Christian Gaebler01:11:23

Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Christian Gaebler

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29 Jan 2022Immune 52: B cell boot camp with Gabriel Victora01:13:33
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Gabriel Victora

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25 Jan 2021Immune 41: Zebrafish immunology with Madina Wane01:23:00

Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Madina Wane

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29 Oct 2024Immune 85: Immune trade-offs01:11:57

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers.

Hosts: Vincent RacanielloCindy LeiferSteph Langel, and Brianne Barker

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02 Jul 2024Immune Booster #1: From bench to bedside to beat HIV with Luis Montaner00:25:47

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne where meet up with Luis Montaner to talk about his career and his research on boosting the immune system to combat viral diseases or cancer progression.

Hosts: Cindy Leifer and Brianne Barker

Guest: Luis Montaner

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05 Jun 2020Immune 32: Immunology of COVID-19, part four01:30:33

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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08 Feb 2020Immune 28: Fish immunology00:56:31

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

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28 Dec 2023Immune 75: Ang Cui unveils the cytokine symphony01:15:03

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo.

Hosts: Vincent RacanielloCynthia Leifer, and Brianne Barker

Guest: Ang Cui

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17 May 2021Immune 44: Got IgA on the brain01:12:12

On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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16 Jun 2021Immune 45: Immune messages01:23:52

On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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08 Nov 2023Immune 73: Big macs01:14:32

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.

Hosts: Vincent RacanielloCynthia Leifer, and Brianne Barker

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23 Jan 2018Immune 4: Putting the immunotherapy CAR T before the cancer01:23:15

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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- Novel Targets
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13 Feb 2019Immune 17: Feed a macrophage, starve a tumor01:08:23

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Steph- Pregnant Scholar
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Vincent- Center for Science in the Public Interest

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21 Feb 2022Immune 53: Dendritic cell robbers01:20:25

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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14 Aug 2019Immune 23: How to tell a mouse from a mouse01:27:12

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Steph- University of Alaska budget crisis
Cindy- 90% survival following new Ebolavirus treatments
Vincent- Immunology videos at Blausen Medical

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19 Jan 2019Immune 16: B is for Bursa01:12:43

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Steph - 7 Days Out
Cindy - Watson PBS documentary and Cold Spring Harbor Laboratory response
Vincent - Dads can donate mitochondrial DNA and Chicken puns

26 May 2024Immune 79: Spa therapy for the immune system01:04:21

Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline.

Hosts: Vincent RacanielloCynthia Leifer, and Brianne Barker

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23 Jul 2024Immune Booster #4: Human autoimmunity with Jane Buckner00:19:51

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity.

Hosts: Cindy Leifer and Steph Langel

Guest: Jane Buckner

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26 Mar 2024Immune 78: Tolerance and tolerating many vaccines01:24:03

Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,  gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge.

Hosts: Vincent RacanielloSteph LangelCynthia Leifer, and Brianne Barker

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08 Sep 2023Immune 71: Can parasitic worms prevent pandemics?01:13:33

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.

Hosts: Cynthia LeiferStephanie Langel, and Brianne Barker

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10 Sep 2024Immune Booster #9: Autoimmune diseases with Mark Shlomchik00:25:05

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Mark Shlomchik to talk about his career and the research of his laboratory on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis.

Hosts: Cindy Leifer and Steph Langel

Guest: Mark Shlomchik

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21 Jul 2018Immune 10: Immune goes viral01:15:39

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Rebecca Lynch

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17 Mar 2025Immune Booster #10 HIV in the brain with Amanda Brown00:30:58

Immune Booster #10 HIV in the brain with Amanda Brown

March 18, 2025

From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection.

Hosts: Cindy Leifer and Brianne Barker

Guest: Amanda Brown

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25 Jun 2024Immune 81: T cells and tolerance with Joseph Larkin III00:41:23

Immune travels to Chicago for the American Association of Immunologists conference where they meet up with Joseph Larkin III to talk about his career and his research on the contribution of T lymphocyte subsets and functions in maintaining tolerance.

Hosts: Stephanie Langel and Brianne Barker

Guest: Joseph Larkin III

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23 Aug 2021Immune 47: Trapping viruses in NETs01:10:51

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

20 Feb 2023Immune 65: Infection infidelities with Jonathan Kagan01:15:40

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity.

Hosts: Vincent RacanielloCynthia LeiferSteph Langel, and Brianne Barker

Guest: Jonathan C. Kagan

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

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