ICU Ed and Todd-Cast (Eddie and Todd)

Send us a Text Message (please include your email so we can respond!)

Episode 1! In this episode we talk about what we're all about and dive right into our first two articles 1)"Defibrillation Strategies for Refractory Ventricular Fibrillation" by Cheskes et al published NEJM 2022 and 2) Comparison of Dopamine and Norepinephrine in the Treatment of Shock by De Backer et al published NEJM 2010. 

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 2! In this episode we again go to a new and old article 1)"Early Active Mobilization during Mechanical Ventilation in the ICU" by the ANZICS group published NEJM 2022 and 2) "Albumin Replacement in Patients with Severe Sepsis or Septic Shock" by Caironi et al published NEJM 2014. 

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 3! In this episode switch it up and review 2 NEW articles that published with SCCM 2023 1)"Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension" or CLOVERS by the PETAL Network published NEJM 2023 and 2) "Effect of Non-Invasive Ventilation After Extubation in Critically Ill Patients with Obesity in France" by De Jong et al published Lancet Respiratory medicine 2023. 

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

BONUS Episode Time! Right after we started the podcast where one of the episodes was the TEAM trial for early mobilization, SCCM happened and there was yet another early mobilization trial. Since we just had an early mobility discussion we decided to drop our thoughts on this, how it relates to TEAM, and a related meta-analysis in bonus episode! Today we talk about 1) "Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomized controlled trial" and 2) "The Effect of Mobilization at 6 Months after Critical Illness - Meta-Analysis"

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

EPISODE 4! In this episode we are SUPER excited to welcome friend of the podcast Whitney Gannon who is our local ECMO expert to talk about the inspiration for her research in ECMO (ECMO liberation and anticoagulation practices in ECMO) AND the INCEPTION trial, or the Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest paper publish in NEJM January 2023 by Suverein et al. This is a little bit of a long episode so some time marks to help you navigate if needed. 14:50 - talking about jargon we HATE. 18:35 - start of discussion of the trial. 35:58 - tangent on drone delivered AED

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 5! In this episode we again go to a new and old article 1) "Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-piece" by Thille et al published NEJM 2022 and 2) "Intravascular Complications of Central Venous Catheterization by Insertion Site" or "3SITES" by Parienti et al published NEJM 2015. 

SBT Strategies: https://pubmed.ncbi.nlm.nih.gov/36286317/
3SITES: https://pubmed.ncbi.nlm.nih.gov/26398070/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 6! In this episode we discuss 1) "Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest" by Ruijter et al published NEJM 2022 and 2) "Dexamethasone treatment for the acute respiratory distress synrome" by Villar et al published Lancet Respiratory Medicine 2020. 

This episode is a little bit longer than normal because we also extended our conversation of steroids in ARDS to the LaSRS (steroids in late ARDS) and Meduri 2007 methylprednisolone in early ARDS studies!

TELSTAR: https://pubmed.ncbi.nlm.nih.gov/35196426/
DEXA-ARDS: https://pubmed.ncbi.nlm.nih.gov/32043986/
Steroids in ARDS CHEST Point: https://pubmed.ncbi.nlm.nih.gov/33422200/
and Counterpoint: https://pubmed.ncbi.nlm.nih.gov/33422201/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 7! In this episode we discuss CAPECOD or  "Hydrocortisone in Severe Community-Acquired Pneumonia" by Dequin et al published NEJM 2023. No second article because this was an important trial which has a lot of messy history that we review, including the ESCAPe trial published last year, before we start our discussion.

We start with a listener question about 3SITES so if you want to skip ahead to the discussion on CAPECOD you can by skipping to the 8:45 time mark

CAPECOD: https://pubmed.ncbi.nlm.nih.gov/36942789/
ESCAPe: https://pubmed.ncbi.nlm.nih.gov/35723686/
CHEST Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/36087797/
Individual Patient Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/29020323/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 8! In this episode we discuss NUTRIREA 3 or  "Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial" by Reigner et al published Lancet Respiratory Medicine 2023. 

The "old" article is NUTRIREA 1 or "Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial"

NUTRIREA 3: https://pubmed.ncbi.nlm.nih.gov/36958363/
NUTRIREA 3 editorial: https://pubmed.ncbi.nlm.nih.gov/37028438/
NUTRIREA 1: https://pubmed.ncbi.nlm.nih.gov/23321763/
Questioning Gastric Residual Volumes: https://pubmed.ncbi.nlm.nih.gov/15699835/

If you enjoy the podcast please share on social media or by word of mouth! Thank you!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 9! In this episode we step a little out of our comfort zone to talk about a couple of analyses which caught our interest recently: 
1) "Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock" published  by Bosch et al March 2023 in JAMA Internal Medicine
2) "Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia" published by MacMillan et al March 2023 in NEJM Evidence

Fludrocortisone: https://pubmed.ncbi.nlm.nih.gov/36972033/
COIITSS: https://pubmed.ncbi.nlm.nih.gov/20103758/
ODM: https://evidence.nejm.org/doi/full/10.1056/EVIDoa2200215
ODM Editorial: https://evidence.nejm.org/doi/full/10.1056/EVIDe2300014

If you enjoy the podcast please share on social media or by word of mouth! Thank you!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 10! In this episode we rambled a little bit and limited ourselves to just our new article which was "Haloperidol for the Treatment of Delirium in ICU Patients" published by Andersen-Ranberg et al in NEJM 2022. Of note, we go back and forth a little bit between "haloperidol" and the brand name "Haldol" but we hope it is similar enough it doesn't impede your listening!

AID-ICU: https://pubmed.ncbi.nlm.nih.gov/36286254/
AID-ICU Bayesian: https://pubmed.ncbi.nlm.nih.gov/36971791/
MIND-USA: https://pubmed.ncbi.nlm.nih.gov/30346242/

If you enjoy the podcast please share on social media or by word of mouth! Thank you!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

ATS 2023! Unfortunately for us, there were more breaking pulmonary articles compared to critical care but we did get this great article by the late Dr. Curtis published in JAMA during the conference "Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness". 

Article: https://pubmed.ncbi.nlm.nih.gov/37210665/

If you enjoy the podcast please share on social media or by word of mouth! Thank you!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 11/12 (depending on how you count the ATS episode)! This time we discuss "Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia" published in NEJM May 2023. Apologies for the lack of old articles, with summer travel plans we've prepped for a couple but ran out of recording time. When things slow down a bit, we'll get back into our normal flow.

PACER: https://pubmed.ncbi.nlm.nih.gov/37224197/

If you enjoy the podcast please share on social media or by word of mouth! Thank you!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

This is a little off schedule (and a little long!) but we were SO EXCITED to have the opportunity to sit down and talk with Matt Prekker, the lead author on the DEVICE trial evaluating video versus direct laryngoscopy for tracheal intubation which was published TODAY, June 2023, in the New England Journal of Medicine and presented TODAY at CCR Meeting 2023. 

DEVICE: https://www.nejm.org/doi/full/10.1056/NEJMoa2301601?query=featured_home
(DOI: 10.1056/NEJMoa2301601)

INTUBE: https://pubmed.ncbi.nlm.nih.gov/33755076/

Please excuse any audio issues! First time recording remotely and we will address volume issues for next time.

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 13! We made it this far! Instead of keying in on one major article from the Critical Care Reviews Conference 2023 we decided to do a pot pourri of the entire conference. It was quite the whirlwind, if there is any point or trial you want us to elaborate please contact us and let us know!

Otherwise we discuss EXIT-SEP in our "short" discussion section. This was published in JAMA Internal Medicine by Liu et al evaluating XueBiJing Injection versus placebo in patients with sepsis. 

EXIT-SEP: https://pubmed.ncbi.nlm.nih.gov/37126332/

As always, if you appreciate the content please share with friends or social media!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Summer is here and we're getting a chance to catch our breath! Unless there is a surprise article drop we anticipate that our next few episodes are going to be a little bit different as we catch up on non-RCT happenings in the critical care world. This episode is the same, our discussion on ARDS is a fascinating history lesson blended in with current insights.

ARDS Guidelines: https://pubmed.ncbi.nlm.nih.gov/37326646/
ARMA: https://pubmed.ncbi.nlm.nih.gov/10793162/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 15! In this episode we talk about "Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest" published October 2022 by Kjaergaard (apologies in advance for the pronounciation...) et al and then talk about the prospective observational cohort "Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE)"

BOX-BP: https://pubmed.ncbi.nlm.nih.gov/36027564/
WEAN SAFE: https://pubmed.ncbi.nlm.nih.gov/36693401/
CT scan after cardiac arrest: https://pubmed.ncbi.nlm.nih.gov/37019352/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 16! In this episode we talk about "Phenobarbital-Based Protocol for Alcohol Withdrawal Syndrome in a Medical ICU: Pre-Post Implementation Study" published April 2023 by Alwakeel et al and then talk about the landmark study TRICC or "A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care"

We also explore car donation jingles (1-877 KARS 4 KIDS

Phenobarbital: https://pubmed.ncbi.nlm.nih.gov/37091477/
TRICC: https://pubmed.ncbi.nlm.nih.gov/9971864/
TRISS: https://pubmed.ncbi.nlm.nih.gov/23281973/
Transfusion in Upper GI bleeds: https://pubmed.ncbi.nlm.nih.gov/25270275/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 17! In this episode we talk about "Aggressive of Moderate Fluid Resuscitation in Acute Pancreatitis" published September 2022 by de-Madaria et al in the New England Journal of Medicine and then talk about the landmark study "Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock" by Rivers et al also NEJM but November 2001

WATERFALL: https://pubmed.ncbi.nlm.nih.gov/36103415/
EGDT: https://pubmed.ncbi.nlm.nih.gov/11794169/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 18! In this episode we talk about "Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial" published March 2023 by Ibarra-Estrada et al in Critical Care. We made a planning mistake so no old article today so we left it short!

Methylene blue: https://pubmed.ncbi.nlm.nih.gov/36915146/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 19! In this episode we talk about "Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation" published November 2022 by Semler et al in the New England Journal of Medicine. We have the first author, Matt Semler, on with us to talk to us about the trial and his improv comedy claim to fame.

PILOT: https://pubmed.ncbi.nlm.nih.gov/36278971/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 20! In this episode we talk about "Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation" published October 2022 by the ANZICS group in JAMA. We have the first author and senior authors on the accompanying systematic review and meta-analysis, Naomi Hammond and Anthony Delany, all the way from Australia (!) on with us to talk to us about the trial.

SuDDICU: https://pubmed.ncbi.nlm.nih.gov/36286097/
Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/36286098/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 21! In this episode we talk about "Extracorporeal Life Support in Infarct-Related Cardiogenic Shock" published August 2023 by Thiele et al in NEJM. Then we dive into our neglected mail bad to try to answer some listener questions.

ECLS-SHOCK: https://pubmed.ncbi.nlm.nih.gov/37634145/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Live show? Thank you so much to the organizers of the ACNP/PA Critical Care Bootcamp who invited us to do a live episode of the show! We talked about the AKIKI2 trial "Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury" by Gaudry et al in Lancet 2021.

AKIKI2: https://pubmed.ncbi.nlm.nih.gov/33812488/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 22! In this episode we talk about "Peripheral Administration of Norepinephrine: A Prospective Observational Study" published August 2023 by Yerke et al in CHEST. For our old article we talk about "Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS)" by Santer et al published October 2020 by Santer et al.

No mailbag this time, we recorded this episode ahead of time to account for travel schedules.

Peripheral Pressors: https://pubmed.ncbi.nlm.nih.gov/37611862/
MIDAS: https://pubmed.ncbi.nlm.nih.gov/32885276/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 23! We spend a little bit of time talking about our recent conference related travel and food experience but dive into our coverage of the trials that released with ESICM including "Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia" by Ehrmann et al published in NEJM and "Landiolol and Organ Failure in Patients With Septic Shock" by Whitehouse et al in JAMA, both October 2023

AMIKINHAL: https://pubmed.ncbi.nlm.nih.gov/37888914/
STRESS-L: https://pubmed.ncbi.nlm.nih.gov/37877587/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 24! Three trials about COVID were published with ESICM which we talk about all three here. COVID has been decreasing in prevalence in our ICU at least so we anchor our discussion around what we can learn from these trials about ARDS in general or what we can carry forward to future pandemics compared to our typical "Are we using this in our practice".

Simvastatin: https://pubmed.ncbi.nlm.nih.gov/37888913/
Vitamin C: https://pubmed.ncbi.nlm.nih.gov/37877585/
Convalescent Plasma: https://pubmed.ncbi.nlm.nih.gov/37889107/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 25! In this episode we talk about the MINT trial or "Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia" published in NEJM November 2023 by Carson et al. We supplement this with a recent observational cohort study that gives Todd anxiety titled "Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients" by Zhao et al in JAMA September 2023.


MINT: https://pubmed.ncbi.nlm.nih.gov/37952133/
TRACS: https://pubmed.ncbi.nlm.nih.gov/20940381/
REALITY: https://pubmed.ncbi.nlm.nih.gov/33560322/
ICH in transfusions: https://pubmed.ncbi.nlm.nih.gov/37698562/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

This was easily our most requested article to discuss and for good reason - Eddie and Todd recently published the ACORN trial or "Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection" in JAMA October 2023. We recognize our bias as the first and last authors on the paper so we wanted to get some other smart people in the studio to balance us out so we partnered with Furf and Monty of PulmPEEPs for this episode. It is simul-dropping on their feed as well. Thank you to them for a great episode and the opportunity to talk about our trial!

ACORN: https://pubmed.ncbi.nlm.nih.gov/37837651/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 27! In this episodes we sit down to talk all about the "when" to intubate a patient centered around acute poisoning in the NICO trial or "Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial" published by Freud et al in JAMA November 2023. 

We ended up talk a lot about that so we cut our old article a little bit short and discuss a couple of JAMA articles about definitive airways in out of hospital cardiac arrest

NICO: https://pubmed.ncbi.nlm.nih.gov/38019968/
PART: https://pubmed.ncbi.nlm.nih.gov/30167699/
Prehospital advanced airway: https://pubmed.ncbi.nlm.nih.gov/23321764/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 28! In this episodes we talk about ECMO! PRONECMO evaluated the effect of prone positioning on patients already on ECMO by Schmidt et al in JAMA December 2023 and then EOLIA by Combes et al in NEJM 2018 which is our old article which randomized patients to ECMO or not. Great discussion here!

PRONECMO: https://pubmed.ncbi.nlm.nih.gov/38038395/
EOLIA: https://pubmed.ncbi.nlm.nih.gov/29791822/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 29! We stray a little bit from our new and old article structure to talk about two recently published but slightly different ARDS recommendations from ATS and ESCIM. We compare and contrast them and give our takes on the data and evidence.

Thanks to everyone who emails in and gives feedback, we will do our mail bag next episode!

ATS Guidelines: https://pubmed.ncbi.nlm.nih.gov/38032683/
ESICM guidelines: https://pubmed.ncbi.nlm.nih.gov/37326646/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 30! This episode is a little different. We recap the SCCM conference first. THEN we go into PROPHY-VAP or "Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury" published January 2024 by Professor Dahyot-Fizelier in Lancet Respiratory Medicine. Then we dive into our long neglected mailbag to review listener questions about MINT, intubation timing, ACORN, and all the steroids in ARDS talk

PROPHY-VAP: https://pubmed.ncbi.nlm.nih.gov/38262428/
SCCM Steroid guidelines: https://pubmed.ncbi.nlm.nih.gov/38240492/
Counter-Point should we use steroids in ARDS: https://pubmed.ncbi.nlm.nih.gov/33422201/
sRAGE in NIV and HFNC: https://pubmed.ncbi.nlm.nih.gov/38250011/
Anaerobes in Aspiration: https://pubmed.ncbi.nlm.nih.gov/37250794/
Anaerobes in Gut: https://pubmed.ncbi.nlm.nih.gov/36229047/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 31! This episode we talk first about invasive vs non-invasive blood pressures from an observational paper titled "Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults" published in journal of Intensive Care Medicine by Haber et al and then for our old trial we further the discussion of blood pressure by talking about the 65 trial!

Non-invasive vs invasive blood pressure: https://pubmed.ncbi.nlm.nih.gov/38215002/
65 Trial: https://pubmed.ncbi.nlm.nih.gov/32049269/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 32! We got a lot of feedback on our last episode so we decided to address it in a full episode! A lot of listeners asked us about vasopressors specifically vasopressin and angiotensin-2 so we talk about VASST, VANISH, and ATHOS-3. It is a full episode but a good one!

VASST: https://pubmed.ncbi.nlm.nih.gov/18305265/
VANISH: https://pubmed.ncbi.nlm.nih.gov/27483065/
ATHOS-3: https://pubmed.ncbi.nlm.nih.gov/28528561/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 33! In this episode we are excited to be joined by Eddy Fan and Whitney Gannon, two extraordinary ECMO researchers to talk about VENT-AVOID or " Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease" published March 2024 by Duggal et al in the ATS Blue Journal.

VENT-AVOID: https://pubmed.ncbi.nlm.nih.gov/38261630/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 34! In this episode we talk about oxygen targets! Specifically we go over the two oxygen target analyses that were published simultaneously with ISICEM. We spend most of our time with HOT-COVID published by Nielson et al and then dip a little into individualized treatment effects of oxygen targets published by Buell et al - both published in JAMA March 2024. The latter is a complex topic and we hit some of the high points but please reach out to us if you want a more in depth discussion!

HOT-COVID: https://pubmed.ncbi.nlm.nih.gov/38501214/
Individualized Treatment Effects: https://pubmed.ncbi.nlm.nih.gov/38501205/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 35! In this episode we talk about extubation practices with "Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial" published in Intensive Care Medicine by Hernandez et al. We then talk about an observation study by Zarrabian et al published in the Blue Journal "Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions".

SPEED UP: https://pubmed.ncbi.nlm.nih.gov/38353714/
Extubation on Pressors: https://pubmed.ncbi.nlm.nih.gov/35107416/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 36! In this episode we talk about tranexamic acid in GI bleeds. We flip the script a little bit and talk about our OLD article first, HALT-IT or "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis: A randomized controlled trial" published in Lancet in 2020. This sets the stage for our new trial "Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis" published in Kumar et al in Hepatology (a new journal for us!)

HALT-IT: https://pubmed.ncbi.nlm.nih.gov/32563378/
TXA and cirrhosis: https://pubmed.ncbi.nlm.nih.gov/38441903/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 37! In this episode we talk about glycemic control in the ICU. We liked the flipped script and so we're again going old article first. NICE-SUGAR or "Intensive versus conventional glucose control in critically ill patients" was published in NEJM 2009 and then we talk about TGC-Fast or "Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU" published NEJM September of 2023 

NICE SUGAR: https://pubmed.ncbi.nlm.nih.gov/19318384/
TGC-Fast: https://pubmed.ncbi.nlm.nih.gov/37754283/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

We're live from ATS! We decide to format our episode after the NEJM/JAMA/ATS combined session and talk about the articles presented there. Some of them we've talked about before but provide new insights from listeners and questions from the audience. Some of them are new and we provide our thoughts from the presentations (not enough time to fully read the articles)

The one article we skip is ASTER that was published in JAMA by Ware et al during the conference. We want to spend a little more time on that one (and potentially have an author as a guest)! Stay tuned!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 39! In this episode we talk about steroids in septic shock from community acquired pneumonia - a secondary from the APROCCHSS trial. We then dive into our mailbag to talk about a couple of topics we've been asked questions about and address them in a more broad sense. A pseudo-mailbag but with real answers

APROCCHSS-CAP: https://pubmed.ncbi.nlm.nih.gov/38310918/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 40! In this special episode releasing at the conclusion of the PREOXI presentation at the Critical Care Reviews 2024 conference in Belfast, Ireland - we discuss the recently published PREOXI trial evaluating NIV vs facemask as pre-oxygenation for emergent endotracheal intubation. Kevin Gibbs, the first author and presenter at the conference, is our special guest.  

Stay tuned for our review of some of the other results from the conference!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 41! We continue our CCR24 recap with a brief overview and thoughts on the conference as a whole and then dive into REVISE or  "Stress Ulcer Prophylaxis during
Invasive Mechanical Ventilation" published by Cook et al in NEJM June 2024. Not the sexiest of all the topics but important nonetheless (and we will get to the others soon!)

REVISE: https://pubmed.ncbi.nlm.nih.gov/38875111/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 42! In this episode we foray into weight lifting and body building as we talked about amino acids for kidney protection after cardiac surgery (PROTECTION) and cycling in addition to PT in mechanically ventilated adults (CYCLE). We also feature our first real ad for the Critical Care ACNP/PA Bootcamp! Details below!

Bagging vs Ventilator During Cardiac Arrest: https://journal.chestnet.org/article/S0012-3692(24)00248-4/abstract
PROTECTION: https://www.nejm.org/doi/full/10.1056/NEJMoa2403769
PROTECTION (pubmed): https://pubmed.ncbi.nlm.nih.gov/38865168/
CYCLE: https://evidence.nejm.org/doi/10.1056/EVIDoa2400137
CYCLE (pubmed): https://pubmed.ncbi.nlm.nih.gov/38865147/

Bootcamp Details:
Vanderbilt University Medical Center is hosting its annual Critical Care ACNP/PA Bootcamp. This multi-specialty conference is designed for nurse practitioners and physician assistants working in critical care. The program, now in its thirteenth year, features a mix of lectures, roundtable discussions, expert Q&A sessions and networking opportunities aimed at both new and experienced providers. #CCBootcamp2024

Dates: September 4-5, 2024 from 08:00 AM - 3:30 PM each day

Target Audience: This course is designed for nurse practitioners and physician assistants working in critical care.

Location: Loews Vanderbilt Hotel located at 2100 West End Ave, Nashville, TN 

Registration: https://www.eventbrite.com/e/vumc-critical-care-acnppa-bootcamp-2024-tickets-830345073467?utm-campaign=social&utm-content=attendeeshare&utm-medium=discovery&utm-term=listing&utm-source=cp&aff=ebdsshcopyurl 

More Info: https://www.vumc.org/advanced-practice-critical-care

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 43! In this episode come close to finishing our dedicated discussion of the CCR24 trials talking about transfusion targets in TBI (HEMOTION) and dapagliflozin in critical illness (DEFENDER)!

HEMOTION: https://www.nejm.org/doi/full/10.1056/NEJMoa2404360
HEMOTION (pubmed): https://pubmed.ncbi.nlm.nih.gov/38869931/
DEFENDER: https://jamanetwork.com/journals/jama/fullarticle/2820242
DEFENDER (pubmed): https://pubmed.ncbi.nlm.nih.gov/38873723/

Bootcamp Details:
Vanderbilt University Medical Center is hosting its annual Critical Care ACNP/PA Bootcamp. This multi-specialty conference is designed for nurse practitioners and physician assistants working in critical care. The program, now in its thirteenth year, features a mix of lectures, roundtable discussions, expert Q&A sessions and networking opportunities aimed at both new and experienced providers. #CCBootcamp2024

Dates: September 4-5, 2024 from 08:00 AM - 3:30 PM each day

Target Audience: This course is designed for nurse practitioners and physician assistants working in critical care.

Location: Loews Vanderbilt Hotel located at 2100 West End Ave, Nashville, TN 

Registration: https://www.eventbrite.com/e/vumc-critical-care-acnppa-bootcamp-2024-tickets-830345073467?utm-campaign=social&utm-content=attendeeshare&utm-medium=discovery&utm-term=listing&utm-source=cp&aff=ebdsshcopyurl 

More Info: https://www.vumc.org/advanced-practice-critical-care

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

We were honored to be joined by Joanna Stollings (and honestly we needed someone to keep us grounded) to talk about BLING3 or "Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis" published in JAMA by Dulhunty et al and also released with the CCR24 conference.

pubmed: https://pubmed.ncbi.nlm.nih.gov/38864155/
JAMA:  https://jamanetwork.com/journals/jama/fullarticle/2819971

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 45! In this episode we talk about sepsis bundles and the 1-BED trial by Fruend et al and discuss the stress ulcer prophylaxis guidelines just published in SCCM!

1-BED (pubmed): https://pubmed.ncbi.nlm.nih.gov/38913098/
SUP Guidelines: https://www.sccm.org/Clinical-Resources/Guidelines/Guidelines/SCCM-ASHP-Guideline-Prevention-of-UGIB

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 46! In this episode we talk about thrombolytic windows in acute ischemic stroke from TIMELESS published by Albers et al published in the New England Journal of Medicine and then we talk about ANDROMEDA shock and serial lactates published by Hernandez et al!

TIMELESS (pubmed): https://pubmed.ncbi.nlm.nih.gov/38329148/
TIMELESS (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2310392
ANDROMEDA-Shock (pubmed):https://pubmed.ncbi.nlm.nih.gov/30772908/
ANDROMEDA-Shock (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2724361

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 47! In this episode we talk about a prospective observational study examining cognitive motor dissociation by Bodien et al published in the New England Journal of Medicine and then we pair that talking about the guidelines for death by neurologic criteria published in SCCM! An episode of somber but important topics!

Cognitive Motor Dissociation (pubmed): https://pubmed.ncbi.nlm.nih.gov/39141852/
Cognitive Motor Dissociation (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2400645 
DBNC Guidelines (pubmed): https://pubmed.ncbi.nlm.nih.gov/37921516/
DBNC Guidelines (CCM): https://journals.lww.com/ccmjournal/fulltext/2024/03000/the_2023_american_academy_of_neurology,_american.3.aspx 

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 48! In this episode we talk about the long term effects of ICU visitation policies on families. 

Long Term Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/39172240/
Long Term Outcomes of Visitation (ICM): https://link.springer.com/article/10.1007/s00134-024-07577-3
Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/31310297/
Outcomes of Visitation (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2738289

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!