From the Spectrum: Finding Superpowers with Autism (Ryan Sumner)
Explore every episode of From the Spectrum: Finding Superpowers with Autism
| Pub. Date | Title | Duration | |
|---|---|---|---|
| 02 Dec 2024 | Part 2 Origins of Autism: Asperger's Autistic Intelligence ("little professors") | 00:30:32 | |
For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. The two-part series intends to remember the phenotypes that appeared and became known as Autism and Asperger's. It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype. If the children described by Asperger in Autistic Psychopathy in Childhood were alive today, they would receive a smorgasbord of diagnosis. Introduction to the Podcast (00:00:00 - 00:00:41,320): Asperger's Work and Concept of Autism (00:00:41,320 - 00:02:21,040): Historical Context and Asperger vs. Kanner (00:02:21,040 - 00:05:10,520): Case Study: Fritz V. (00:05:45,080 - 00:11:25,920):
Case Study: Harold L. (00:13:21,040 - 00:15:25,240):
Case Study: Ernest (00:17:37,960 - 00:21:00,160):
Case Study: Hellmuth L. (00:21:16,680 - 00:24:40,240):
Common Features Across Asperger's Cases (00:24:49,600 - 00:26:29,720):
Asperger's Insights on Autistic Intelligence (00:26:29,720 - 00:27:37,760):
Reflection on Autism as a Phenotype vs. Disorder (00:27:37,760 - 00:29:12,680): Historical Figures and Autism (00:29:12,680 - 00:29:41,480):
Conclusion (00:29:41,480 - 00:30:42,800): Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 26 Aug 2024 | Jonathan Mitchell: Senior Citizen Autistic, Author, and Advocate Challenging the Status Quo of Research and Neurodiversity | 00:55:54 | |
My guest today is Jonathan Mitchell. Jonathan is a senior citizen Autistic, Author of numerous novels and blogs, and stands up for the purpose of Autism. His blog, Autism Gadfly, provides perspectives of Autism otherwise not considered by the lay-public or researchers in Autism. Jonathan's views have been mentioned in Newsweek, NPR, Autism Daily Newscast, and HuffPost. Jonathan was born in 1955 in Los Angeles. We discuss his experience at an early age including psychoanalytic therapy, psychological assessment, and troubles through education. Eventually, Jonathan and his family learned about Autism while on a trip to the East. Jonathan faced many challenges through his education in different schools beginning in kindergarten. However, Jonathan graduated from UCLA with a bachelors of arts in psychology. We also discuss challenges in professional and personal life as an adult where he faced various barriers. In the early 2000s, when the internet allowed for different communication platforms, Jonathan began to call out things wrong in Autism. In addition, he carries a loud voice for a cure/treatment for Autism. Recently, you can find him on X as he continues to be a voice for the Autistic community. X: https://twitter.com/autismgadfly Jonathan Mitchell website http://www.jonathans-stories.com Wikipedia https://en.wikipedia.org/wiki/Jonathan_Mitchell_(writer) | |||
| 10 Feb 2025 | Autism and Speech & Language | 00:32:41 | |
In this episode, we discuss the intricate relationship between Autism and speech & language, emphasizing the critical role of neuroscience in understanding these dynamics. The discussion begins by highlighting how speech and language are foundational to human evolution and social interaction, yet pose unique challenges for individuals with Autism. The episode explores the brain's key regions involved in these processes, such as Broca's area, responsible for speech production, and Wernicke's area, crucial for language comprehension. These regions are connected by the arcuate fasciculus, a white matter tract essential for language processing, repetition, and verbal working memory. The podcast also examines how the basal ganglia, particularly the dorsal striatum, contributes to speech fluency and motor sequencing, including the articulation of words. By integrating neuroscience, we gain insight into the biological underpinnings of communication difficulties in Autism, such as delays in language processing and the phenomenon of "choppy" speech, which are linked to less coherent organization within these neural pathways. The episode further unpacks the concept of neuroplasticity and its implications for Autism, emphasizing the brain's ability to adapt through practice and repetition, leading to habits. The discussion also touches on the role of the dorsal medial striatum in goal-directed learning and the dorsal lateral striatum in habit formation, illustrating how these areas influence speech and language acquisition. Additionally, the podcast explores the phenomenon of echolalia, often observed in Autistic individuals, as a potential mechanism for processing delays or as a result of cyclical loops in the basal ganglia. The interplay of neurotransmitters like GABA and glutamate is highlighted, explaining the excitation-inhibition imbalance often seen in Autism, which affects sensory processing and communication. By framing these challenges through the lens of neuroscience, the episode underscores the complexity of social interaction for Autistic individuals and the importance of understanding the brain's predictive and adaptive mechanisms to better support their needs. 00:00 - Introduction to Autism and Speech 02:02 - The Speaker-Receiver Dynamic in Autism 04:02 - Visual Thinking and Processing in Autism 06:18 - Neuroscience of Speech and Language 08:20 - The Role of the Basal Ganglia in Speech 10:39 - Echolalia and Sensory Processing Delays 16:53 - Neuroplasticity and Speech Therapy 17:22 - Reflexes, Inhibition, and GABA in Speech and Autism 20:02 - Basal Ganglia Circuits, Motivation, and Echolalia from getting "stuck" 24:03 - Language Acquisition and Rule-Setting in Autism 27:47 - Energy, Learning, and Social Challenges 30:15 - Contingency-Based Learning and Outcomes 31:46 - Reviews/Ratings and Contact info Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 21 Oct 2024 | Nicole Rincon, PA-C: Investigating Autism from a Parental and Functional Medicine Approach | 01:14:27 | |
In this episode, we discuss Autism with Nicole Rincon, PA-C from Rossignol Medical Center. Nicole Rincon is a board-certified Physician Assistant (PA-C) who specializes in Pediatric Special Needs, MAPS (Medical Academy of Pediatric Special Needs), Integrative, and Functional Medicine. At Rossignol Medical Center, she is actively involved in patient care, research, and educational content. Nicole adopts valuable holistic and patient-centered care approaches in her practice. Nicole also brings a deeply personal perspective to the discussion as a mother of children with regressive Autism. This personal journey has fueled her motivation to explore the complexities of Autism, leading her to Rossignol Medical Center. Prior to this, Nicole spent years in medical weight management, focusing on nutritional counseling and wellness supplementation. This background provides her with unique insights into the metabolic, gastrointestinal, and environmental factors influencing Autism. Disclaimer: This is not Medical Advice Nicole Rincon https://www.nicolerincon.com/nicole-rincon Rossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/ TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdf TACA Talks: https://www.nicolerincon.com/videos X: https://x.com/NicoleRinconPA Publications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articles 0:00 Nicole Rincon 2:07 Nicole's Personal and Professional Journey into Medicine and Autism; "Who's the guy in Charge?" 12:30 Understanding Autism Trough Research and Interventions; Regression; Omegas and Toxins 21:56 Functional Medicine Approach to Autism; Rossignol Medical Center 25:07 Introduction to various Folate factors, Folate Receptor Antibodies, and Methylation 30:36 The Role of Mitochondrial Dysfunction and the many Comorbid Conditions of Autism (Autism and X, Y, Z) 36:02 Collaborative Approach at Rossignol Medical Center; Research Insights and Opportunities from Nicole's multiple roles 42:22 Challenges with the Current Medical Paradigm 44:09 Maternal Health and its Impact on Autism 48:34 Investigating Autism Beyond Vaccines 50:59 The Role of Light and Environment in Human Biology; Electrons and Magnetism 53:26 Introduction to Nicole's Comprehensive Evaluation from a Functional Medicine Approach; Understanding the Patient and Upstream Dysfunctions 1:02 Multifactorial Approach 1:05 The Future of Medicine, integrating Functional and Patient Center Care 1:13 Reviews/Ratings and Contact Info Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 25 Sep 2024 | Research at UT-Austin using Infrared Light | 00:05:46 | |
For today, just a brief introduction to research beginning at UT-Austin, University of Texas at Austin, led by Dr. Francisco Gonzalez-Lima. The study is called: Effects of Transcranial Infrared Light Stimulation on Symptoms of Autism Spectrum Disorder. In the link below, it is Study #2. Dr. Francisco Gonzalez-Lima https://dellmed.utexas.edu/directory/francisco-gonzalez-lima Research Link (Study #2) https://labs.la.utexas.edu/gonzalez-lima/participate-in-our-research/ Research Team https://labs.la.utexas.edu/gonzalez-lima/team/ Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 03 Mar 2025 | Part 2 Autism and Sensory Processing: Scientific Literature | 00:37:56 | |
For today's episode, we expand on Autism and Sensory Processing. We return to the mesencephalon—a brainstem region with superior and inferior colliculi—as a critical hub for sensory integration and attention bias. We cover four scientific articles, starting with Marco et al. (2011), which uses EEGs, MEGs, and fMRIs to reveal autism’s auditory processing inconsistencies (e.g., delayed N100/M100 cortical responses), tactile hypersensitivity from overactive receptors, and visual processing quirks like reduced fusiform gyrus activation for faces. Russo et al. then explore brainstem-level deficits, showing autistic children’s auditory brainstem responses (ABR) to speech syllables like "DA" exhibit poor neural synchrony and phase locking, especially in noise, due to disrupted wave V, A, D, F timing—linking these to language impairments. These findings point to biological roots, including denser neocortical mini-columns (30-40 vs. 50-60 microns in controls) and cerebellar Purkinje cell loss, impairing local processing and long-range connectivity. The episode continues with Leekam et al. (2007), confirming over 90% of autistic individuals have multi-modal sensory abnormalities—hypo- and hypersensitivity tied to serotonin and GABA dysregulation—persisting across life, while Tomchek and Dunn (2007) note 95% prevalence via caregiver reports, hinting at neural pathway disruptions. At some point, we need to acknowledge the mesencephalon’s embryological stasis as one of four neural cell types, suggesting its evolutionary role in sensory modulation is key to Autism’s biology. These articles collectively highlight altered neural circuitry, from brainstem to cortex, and biases us to remaining within ourselves. Remember, the biology that gives us Autism allows us to be comfortable within ourselves. Marco et al 2011 https://www.nature.com/articles/pr9201193 Russo et al 2009 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1467-7687.2008.00790.x Leekam et al 2007 https://link.springer.com/article/10.1007/s10803-006-0218-7 Tomchek & Dunn 2007 https://affectautism.com/wp-content/uploads/2016/05/tomcheck_dunn.pdf 0:00 Autism and Sensory Processing; comorbid conditions; Mesencephalon 3:03 Article 1 Marco et al 2011 4:11 Auditory 5:00 N100 & M100 tools 9:17 Tactile 11:23 Visual 13:53 Multisensory Integration 15:16 Postmortem; Cerebellum & Purkinje Cells; Minicolumns 17:06 Speech 19:02 Article 2 Russo et al; Brainstem scientists 20:28 Auditory Brainstem Response (ABR); Quiet versus Noisy environments; Beatles comparison 23:49 Neural Synchrony; Waves V, A, D, F 24:33 Phase Locking 27:34 Article 3 Leekam et al 2007; Neuroplasticity 33:09 Article 4 Tomchek & Dunn 2007 36:36 Reviews/Ratings and Contact Info Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 17 Mar 2025 | Neurulation, Neuroepithelial Cells, & Mesencephalon | 00:39:19 | |
Why doesn't the MESENCEPHALON further subdivide into larger regions of the brain? In this episode, we will expand on the neurulation time and focus on the brain formation, spotlighting the proencephalon, mesencephalon, and rhombencephalon, which emerge around days 22–23 of embryonic life. The proencephalon (forebrain) splits into the telencephalon—think cerebral hemispheres for cognition—and the diencephalon, home to the thalamus and hypothalamus for sensory and hormonal control. Meanwhile, the rhombencephalon (hindbrain) divides into the metencephalon (pons and cerebellum, key for movement) and myelencephalon (medulla, handling [mostly] autonomic essentials like breathing). The mesencephalon stands out as a non-subdividing relay hub. The mesencephalon offers tremendous insights into the Autistic phenotype with its roles in biasing the living organism's attention to the environment. Autism and the Womb https://youtu.be/NOVp4mIroug Autism, Neurulation, & Embryogenesis https://youtu.be/TXkc93uGNuw Autism & Eye Movements https://youtu.be/1amB5e9qzg4 Autism & Sensory Processing Part 1 https://youtu.be/HPvwvtu5hB4 Autism & Sensory Processing Part 2 https://youtu.be/iWy9Rligzic Daylight Computer Company https://daylightcomputer.com use "autism" in the discount code for $25 coupon. This is the future of tech. Chroma Light Therapy https://getchroma.co use "autism" for a 10% discount, 0:00 Daylight Computer Company 04:22 Neuralation and Brain Development 05:09 Maternal Factors and Biomarkers (Tyrosine, Hypothyroidism, etc.) 06:46 Tryptophan and Its Role in Embryogenesis 08:34 Environmental Insults and Toxins 09:19 Embryogenesis and Brain Formation (Proencephalon, Mesencephalon, Rhombencephalon 10:43 Telencephalon 10:57 Diencephalon 12:34 Rhombencephalon 12:52 Metencephalon 13:35 Myelencephalon 15:12 Evolutionary Perspective of the Mesencephalon 21:39 Chroma Light Devices 24:48 Mesencephalon’s Role in Motor Control, Sensory Processing, and Autism; 27:12 Extrapyramidal motor system; Substantia Nigra, Red Nucleus 30:11 Additional Nuclei of the Midbrain; Ocular Motor Nuclei; Edingher-Westphal; Trochlear nerve 31:58 Paraaqueductal Gray (PAG), "Retard Strength" and Its Role in Pain, Behaviors and Autism; "Freezing" in Flight, Fight, & Freeze 36:00 Eye Movements; learning & Neuroplasticity; Motor Planning, Proprioception, Language and Speech 38:20 Wrap Up Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 30 Dec 2024 | A Year in Review | 00:29:09 | |
A Year in Review from previous episodes. 00:00 - Intro 00:42 - Warning Against Comparing Rates; why comparing autism rates across different time periods is misleading due to changes in diagnostic criteria and definitions. 02:07 - Historical Context; the Bayh-Dole Act, DSM acceptance of Autism, and changes in vaccination schedules, affecting Autism definitions; Core Autism Characteristics 04:30 - Educational Challenges; Describes the typical school day's structure as potentially overwhelming for Autistic individuals due to frequent subject changes. 05:36 - Intense Focus; Autistic individuals might fixate on topics with abnormal intensity or focus, which is a hallmark of Autism. 08:40 - The biology of Autism allows us to be comfortable within ourselves; contrasting with societal expectations. 09:09 - Employment and Anxiety; Considers how the expectation to fit into social norms can lead to anxiety and challenges in employment for Autistic individuals. 10:10 - ADHD and Autism; Challenges the notion of coexisting ADHD and Autism, 14:26 - Early Detection; UCLA study on very young children showing altered salience network connectivity, hinting at early signs of Autism. 14:49 - Developmental Timing; emphasizes that Autism likely starts in the womb, suggesting prenatal development as a critical area for research. 15:14 - Neurodevelopmental Perspective; Autism as underdeveloped or abnormally developed cells, linking it to broader neurodevelopmental disorders. 16:03 - Comorbid Conditions: Explores the concept of Autism being associated with various other conditions due to shared developmental issues. 16:47 - Biological Processes: cellular proliferation, differentiation, and migration in the womb, crucial for brain development. 17:41 - Mitochondria and Autism 18:30 - Oxytocin & Autism; oxytocin as a molecule of interest, particularly its pathways and their implications for social behavior in Autism. 20:29 - Social Reward System; Explains how oxytocin and serotonin interaction in the brain contributes to the rewarding nature of social interaction, which might be lacking in Autism. 21:21 - Serotonin Synthesis; Details the synthesis of serotonin in both the GI tract and the brain, mentioning the enzymes involved and their significance. 22:34 - Tryptophan and Light; Discusses how light affects tryptophan, an amino acid precursor to serotonin, and its role in biological processes. 23:33 - Supplementing Relationships; Explores how visual thinking and movies can serve as a form of interaction for Autistic individuals, offering comfort or learning. 25:17 - Visual Learning; Highlights the concept of "thinking in pictures" and how it leads to accelerated learning or Autistic intelligence. 27:47 - Autistic Comfort and Societal Expectations; Advises against forcing Autistic individuals into societal norms that don't align with their natural inclinations, emphasizing understanding and acceptance Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 09 Dec 2024 | Dr. Hanna Stevens, MD & PhD: The Relationship of the Placenta, Womb, & Development | 01:01:15 | |
For today’s episode, Dr. Hanna Stevens joins me to discuss early prenatal factors of early brain development. Dr. Stevens received an MD and PhD in Neuroscience from the University of Illinois. Dr. Hanna Stevens leads the Psychiatry and Early Neurobiological Development Lab at the University of Iowa Carver College of Medicine. Dr. Stevens is a distinguished Professor of Psychiatry and holder of the Ida P. Haller Chair. Her work leads groundbreaking research into the molecular and cellular foundations of early brain development, and is pivotal in linking prenatal stress, environmental factors, and genetic influences on childhood behavior and the emergence of disorders. With a focus on the critical periods of pregnancy and early childhood, her research aims to revolutionize the diagnosis and treatment of conditions throughout the lifespan. By the end of this episode, we hope you receive valuable information about the Placenta, Womb, and Development. Dr. Hanna Stevens https://medicine.uiowa.edu/psychiatry/profile/hanna-stevens Iowa Healthcare https://uihc.org/childrens/providers/hanna-e-stevens Psychiatry and Early Neurobiological Development Lab (PENDL) https://stevens.lab.uiowa.edu Publications https://stevens.lab.uiowa.edu/publications 0:00 Dr. Hanna Stevens 2:00 Journey into Neuroscience and Psychiatry 8:13 Prenatal Development of Autism 14:02 The significance of NF-kB in Brain Development 23:10 Serotonin; Leukocytes as a window into our Biology; Cortisol 29:02 Steroid Hormones and Stress & Development 34:12 Methylation 40:00 Cell Proliferation & Migration in Fetal Development; Antioxidants 45:56 Oxidative Stress; Mitochondria; Antioxidants 48:30 Quantum Biology/Physics ** Me shaking my head at minute 48:50 is not intended at Dr. Stevens, but at myself because I tell myself not to keep going to the electrons and light for a Cause of Autism to guests 53:19 Future Research & Dorsal Striatum; Volume; Brain Development 1:00 Reviews/Rating; Contact Info Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 19 Dec 2024 | This is my experience 2: Autism and Education & Social Communication | 00:09:36 | |
In this brief episode, we discuss keeping up in the classroom during teacher lecture. Specifically, we discuss the delays in sensory processing, taking notes, visual thinking, and some challenges with keeping up. This is a pressing issue for Autistics, and in my opinion, education needs to do better for the Autistic phenotype. Autism and Education https://youtu.be/zQpNtvS-tWw Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 13 Apr 2024 | Part 1: Excitation / Inhibition Imbalance with Autism and Development, Melanin, Melanopsin, and BDNF | 00:30:44 | |
In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors. See Dr. Jack Kruse Quantum Engineering 45 Email: info.fromthespectrum@gmail.com | |||
| 16 Dec 2024 | Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB | 00:35:53 | |
For today's episode, we discussing transferring energy from the environment across our biology. We discuss a few quantum theories, atoms, molecules, water, DHA, and NF-kB. Life on Earth is driven by energy from the environment, and this could be missed with humans, and especially with developmental problems like Autism. Water Podcast 1: Rubin, Kruse, Huberman https://www.youtube.com/watch?v=0lBAcUMGIeI&t=43s Water Podcast 2: Gulhane and Kruse (Light changes the Physics of Water !) https://www.youtube.com/watch?v=l9Ubguvfpys Water Podcast 3: Gulhane and Kruse https://www.youtube.com/watch?v=W5w0WainlMM https://www.plefa.com/article/S0952-3278(12)00147-0/abstract Quantum-coherent energy transfer: implications for biology and new energy technologies https://pmc.ncbi.nlm.nih.gov/articles/PMC3385675/#:~:text=In%20the%20simplest%20picture%2C%20quantum,transport%20at%20the%20molecular%20scale. Quantum cognition: The possibility of processing with nuclear spins in the brain https://www.sciencedirect.com/science/article/abs/pii/S0003491615003243 Role of semiconductivity and ion transport in the electrical conduction of melanin https://www.pnas.org/doi/10.1073/pnas.1119948109 0:00 Intro 0:40 Quantum Biology, Coherence, Thermodynamics, Water, DHA, NF-kB, and transferring energy - Atoms & Molecules 2:00 Oxygen and CCO; Mitochondria 3:55 Quantum Biology; Environments influence Atoms & Molecules 5:50 Coherence & States; Light guides Life on Earth; Light provides Energy after it hits Matter 7:16 Modern Human Environments 7:41 Quantum Thermodynamics; Melanin, Electrons; Rules 9:03 Biophotons, Photons and Lux; Seasonal Impact 11:15 Electrons & Mitochondria; Real sources of Energy 12:00 Artificial Light versus 280nm-3100nm Light; Big Harma & GLP-1 sidebar 14:16 Autism and Loss of Biological Energy; changes in Light 15:43 Electrons in Biology; Water; Coherent Domains; Semiconductors 17:15 DHA; Electron Efficiency; Cells; Photoreceptors and Converting Energy and Developing Nervous Systems (plural) 19:20 Phylogeny of Oxytocin and DHA sidebar; pi-electons; DHA dictates DNA 22:40 Jack Kruse Quote 23:36 Cells, Tissues, & Synapses; Origins of Autism; DHA roles 26:14 Autism and X, Y, Z comorbid conditions (plural); definitions of Autism (modern versus origins), Criteria 29:23 DHA takeaways; efficiency 31:41 NF-kB; creating the womb and nervous systems; Autism and Orbitofrontal Cortex (OFC) 35:06 Reviews/Rating & Contact Info | |||
| 22 Apr 2024 | Part 2: Excitation / Inhibition Imbalance with Autism and Metabolic "Bank" Account and Demands, and Background Biology | 00:25:24 | |
In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world. Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life. https://www.nature.com/articles/s41398-023-02317-5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/ https://www.nature.com/articles/s41398-018-0155-1 https://www.nature.com/articles/nature10360 https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmed https://www.nature.com/articles/s41380-022-01506-w (0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena (4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum (10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation (15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical (20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I (22:25) Wrap-up and understanding Autism, and Contact Info | |||
| 17 Apr 2025 | (Re-Release) Autism & Education | 00:40:53 | |
In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction. Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618 Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/ Thinking in Pictures https://www.grandin.com/inc/visual.thinking.html Autism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s (0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment (7:00) The Prescription Era; Medication first Paradigm (10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning; (13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not? (13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism; (14:39) Subject Switching and Criteria B conflict (17:14) If you have met one child with Autism, you have met one child with Autism (17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience; (23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics; (27:00) Art was fine, other subjects were not fine; Details to General versus General to Details; (27:58) High School personal experiences; Pathway to Success ＞ General Education; (29:52) Did I graduate, or Not? (31:56) SAT (32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses) (36:34) Education Arrangement; Taking Notes is challenging (39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information | |||
| 27 Jan 2025 | Autism and the Basal Ganglia: Repetition, Sameness, & Habits | 00:23:09 | |
In this episode, we delve into defining the Autistic Phenotypes, emphasizing that while these traits are straightforward to identify, understanding their depth and impact requires integrating real-life data and personal experiences. We explore the characteristics of repetitive behaviors, habits, restricted interests, and a rigid adherence to schedules, which are pivotal to the Autistic Phenotypes. We will also discuss the Basal Ganglia pathways, specifically how the direct and indirect pathways influence these behaviors, touching upon how these neural connections relate to both the strengths (Superpowers) and challenges (Superdeficits) faced by individuals on the spectrum. Our discussion extends into the biological and social aspects of autism, examining how the inherent biology of autism can lead to comfort within oneself, yet creates struggles when forced into societal norms. We'll address the notion of conflict within the nervous system, explaining how it responds reflexively to disruptions in established patterns or expectations. The episode will also cover the neurological underpinnings of autism, including the roles of dopamine, GABA, and the substantia nigra in modulating behaviors and habits. We'll connect these insights to the adaptive responses or the lack thereof, which are central to understanding why individuals with Autism might resist changes in routines or show intense focus on specific interests. Practical implications and the historical context from early Autism studies by Leo Kanner and Hans Asperger are revisited, offering a comprehensive view on how these traits manifest in real-life scenarios and affect social interactions 00:00 Understanding Autistic Phenotypes: Repetitive behaviors, restricted interests, and adherence to schedules. Basal Ganglia & strengths (superpowers) and challenges (superdeficits). 05:23 Neurological Mechanisms: Basal Ganglia's pathways (direct and indirect) & Autistic behaviors. Repetitive actions, learning, and habit formation; dopamine, excitation and GABA; Stemming and the discomfort with unpredictability in social contexts. 10:39 "Motivation", Movement, and Social Interaction: "Motivation" and motor movements & the basal ganglia & Autism; Social interactions & unpredictable, significant challenges & predictability. The segment also links these neurological pathways to DSM criteria for autism, highlighting the interrelation between motor and social behaviors. 15:55 Neuroplasticity and Adaptation: Neuroplasticity & the repeated strengthening of neural connections shape Autistic traits; adaptive responses managed by the prefrontal cortex, and resisting changes or adhere to routines. 20:52 Biological Energy: brain's energy management for learning and habit formation works in Autism; acetylcholine for focus, dopamine for persistence Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA TikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcast email: info.fromthespectrum@gmail.com | |||
| 18 Nov 2024 | Dr. Eric Weiss, MD: Umbilical Cord Stem Cell & Regenerative Medicine for Autism | 01:07:46 | |
For today's episode, Dr. Eric Weiss, MD, explains an exciting medical approach for Autism. Dr. Weiss, who holds board certification in Plastic and Reconstructive Surgery, is a notable figure in regenerative medicine. Dr. Weiss is a Veteran of the U.S. Navy. Dr. Weiss attended Duke University Medical School for his medical degree, completed his General Surgery Residency at the University of California, San Francisco (UCSF), and did his Plastic Surgery Residency at the University of Miami. He has a special interest in using regenerative therapies to address autism. Dr. Eric Weiss recounts his journey into innovative medical practices, moving away from conventional pharmaceutical treatments. As a father to Marston, his dedication to exploring treatments for autism stems from personal experience. Throughout his story, his enthusiasm for natural healing methods is evident. By the end of this episode, listeners should gain insight into a thoroughly researched medical intervention that's gaining traction in the autism community. Dr. Eric Weiss, MD: https://northfloridastemcells.com Dr. Eric Weiss, MD: https://linktr.ee/neflps Educating Marston: https://www.educatingmarston.com Disclaimer: This is not Medical Advice. 0:00 Dr. Eric Weiss, MD 1:55 Dr. Weiss's Medical Journey 5:01 Intersection of Autism and Stem Cell Research 12:09 Personal Experience as a Parent with Autism 15:58 Understanding Umbilical Cord Blood Treatment 22:39 The Process of Umbilical Cord Blood Donation 25:55 The Science behind Stem Cell Healing 32:31 Future of Regenerative Medicine 34:24 Natural Healing and Lifestyle, Not Big Pharma 36:56 Mitochondrial Function & Energy Production 39:09 The Impact of Light on Health 41:07 Understanding Inflammation & Modern Disease 44:30 Stem Cell Therapy: Mechanisms & Effects 48:41 The Future of Medicine: Beyond Pharmaceuticals 54:14 Professional Transition into Stem Cell and Regenerative Therapy 58:05 Exploring Cytokines & Interleukins; Patterns of Disease; Dr. Weiss's Contact Info 1:07 Reviews/Ratings; Contact Info Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 09 Sep 2024 | Autism and Mitochondria: Biophysics meets Biochemistry | 00:41:09 | |
In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons. Jack Kruse https://www.patreon.com/DrJackKruse/posts Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycle Oxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylation 0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration 4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO) 6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS) 8:25 Glycolysis 10:03 Citric Acid cycle 12:02 OXPHOS 13:51 Cytochrome I 15:07 Cytochrome II 16:08 Cytochrome III 17:10 Cytochrome IV and creating water 19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism 29:20 Cytochrome V and ATPase; Chromophores 33:56 Evolution and losing electrons; Autism and modern health complications 37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies 40:23 Reviews/Ratings and contact info X: https://twitter.com/rps47586 Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 08 Jul 2024 | Dr. Leanna Hernandez: Genetic Variation and Brain Connectivity of Autism, the Oxytocin Receptor Gene, and Sex- and Diagnosis-Differences | 00:46:24 | |
In this episode, we discuss Autism with Dr. Leanna Hernandez. Dr. Hernandez is an Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and director of the Hernandez Lab. She is a member of UCLA’s Center for Autism Research and Treatment, Center for Neurobehavioral Genetics, and the Brain Research Institute, and serves as Co-Director of the Genetics, Genomics, and Informatics Core for UCLA’s Intellectual and Developmental Disabilities Research Center. Hernandez Lab https://www.hernandezlabucla.org Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism https://www.nature.com/articles/mp2016209 Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity https://www.nature.com/articles/s41398-020-0750-9 Oxytocin and Vasopressin and the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273 https://www.youtube.com/watch?v=DAtmC-s1_e0 (0:00) Intro; Dr. Leanna Hernandez (2:24) Autistic Phenotypes (4:13) Dr. Hernandez education journey into Autism and the Hernandez Lab (9:03) 2017 Paper Oxytocin Receptor Gene, Common Genetic Variance, Single Nucleotide Polymorphisms (SNP), and Reward and Social Processing and the Nucleus Accumbens (NAc) (15:10) Differences in Brain Connectivity between Autistics and Non-Autistics (20:06) Social Cognition, Boy Bias in Autism; GENDAAR Consortium and Sex- and Diagnosis-Differences (21:48) GENDAAR (22:45) Boys versus Girls Connectivity involving the NAc with and without Autism (25:38) Different Connectivity correlated with Different ADOS scores for Repetitive Behaviors (26:35) Female Protective Effect for Autism; Camouflaging/Masking (30:19) The Assessment process for Girls and the Oxytocin Receptor Gene Sex Differences and Socialness and understanding the Boy Bias (32:48) Current Research and a Genome Wide approach and Polygenic Risk Scores (35:10) Oxytocin and Excitation/Inhibition (37:08) Sharing Information and Current Research (41:45) The Future of Autism Research (45:48) Reviews/Ratings and Contact Info email: info.fromthespectrum@gmail.com | |||
| 15 Jul 2024 | Cause of Autism: Autism is a Modern Biological Adaptation to a Common Environmental Change- Light. | 01:16:12 | |
Autism just magically shows up. In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases. The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics. "... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse (Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uA Tetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMI Tetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4 Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXs Tryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079rev Autism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277 Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567 Regions of Interest: Atoms, Aromatic Amino Acids, Artificial Light, Chromophores, Cytochromes, Electromagnetic, Embryo, Folate Acid (and Folic Acid) Sunlight, Melanin (Neuromelanin), Melanocytes, Melanogenesis, Melanopsin, Mitochondria, Neuroectoderm, Neuroplasticity, Periodic Elements, Photoelectric Effect, Pro-opiomelanocortin (POMC) Proteins (wide-band gap semiconductors), Serotonin, Tryptophan Hydroxylase 1 and 2, Vitamins A, b9 (Folate/Folic Acids), B12, and D, Water X: https://twitter.com/rps47586 Facebook: https://www.facebook.com/fromthespectrum.podcast Email: info.fromthespectrum@gmail.com | |||
| 13 Jan 2025 | Autism and the Basal Ganglia: "Motivations" & Movements from Learning and Habits | 00:33:36 | |
In this episode, we explore the Basal Ganglia. The basal ganglia are a group of subcortical nuclei that play a crucial role in orchestrating movement. They are involved in what's known as the 'Go, No-Go' decision-making process, where they help decide whether to initiate or suppress actions. This region is critical where motivation translates into action. When discussing "motivations," we must be cautious; motivations aren't consciously defined by us but by our nervous system, which operates based on learned behaviors, habits, and neural pathways. The nervous system is designed to conserve energy by automating responses, which explains why it favors habit formation over constant conscious decision-making. It responds based on what it has learned, including connections, habits, and the rules established by our internal calculators. General Description of the Basal Ganglia: Inputs: Caudate Nucleus and Putamen Relays: Globus Pallidus External (GPe) and Subthalamic Nucleus Outputs: Globus Pallidus Internal (GPi) and Substantia Nigra Pars Reticulata (SNr) Modulator: Substantia Nigra Pars Compacta (SNc) 00:00 - Defining the Autistic Phenotypes. 00:17 - Exploration of basal ganglia, focusing on the dorsal striatum. 00:40 - Explanation of connecting Autistic Phenotypes with behaviors and implications through biology. 01:00 - Detailed description of the basal ganglia's role in subcortical functions. 01:50 - Discussion on the relationship between eye and brain development. 02:18 - Explanation of basal ganglia's role in motivation and movement convergence. 03:02 - Insight into how the nervous system conserves energy and responds to known patterns. 03:52 - Explanation of why change is hard due to basal ganglia functions. 04:37 - paper on excitation-inhibition phenomena in autism. 05:07 - Genetic implications in autism: SHANK3, Neuroexcin, Neuroligin, 06:45 - Discussion on the enlargement of the dorsal striatum in autism. 08:07 - Identification of the caudate nucleus and putamen as inputs to the basal ganglia. 09:40 - Role of the putamen in motor skill acquisition and fine-tuning movements. 11:59 - Connection between the putamen and Autism-related motor behaviors like stimming. 13:30 - Discussion on Autistics preferring their inner world. 16:04 - Importance of the substantia nigra and dopamine in human function. 18:26 - Dopamine receptors and their roles in Autism. 20:03 - Subdivisions of the substantia nigra and their functions. 21:01 - Description of the globus pallidus and its role in basal ganglia circuits. 22:29 - Feedback loops involving the globus pallidus and subthalamic nucleus. 23:40 - Implications of delayed or inefficient signal loops in movement control. 24:57 - Role of the thalamus in processing sensations. 26:31 - Subthalamic nucleus as a major relay center for motor control. 28:47 - Linking Autism criteria with basal ganglia function. 30:20 - Coverage of all four criteria B symptoms related to Autism. 32:14 - Morphology of neural connections in Autism. 32:51 - Reviews and ratings. Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA TikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcast email: info.fromthespectrum@gmail.com | |||
| 02 Sep 2024 | An Overlooked Distinction of Autism and ADHD: These are Two Different Conditions | 00:41:26 | |
In this episode, we challenge the modern trend of Autism and ADHD comorbid diagnosis. We will use children from Kanner and Asperger to show these so-called ADHD symptoms are simply parts of the Autistic Phenotype. However, society finds it easier to lump these two conditions together, and we question why. We review both, the inattentive criteria and the hyperactivity and impulsivity of ADHD and explain when the Autistic phenotype exhibit these conditions. The criteria for ADHD are downstream behaviors seen across multiple reasons and act as a collect-all. I did not say ADHD does not exist, but I do say Autism and ADHD existing simultaneously seems unlikely if you really understand the phenotypes. Might it just be easier for society to lump these together instead of challenging the differences? B.3 and Inattention are complete opposites. Hyperactivity and Impulsivity can show up when anyone is in the wrong or horrible environment. Autism and ADHD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918663/ Hans Asperger https://psycnet.apa.org/record/1992-97284-002 0:00 Intro; Brief Note on how environmental signals such as electromagnetic fields (EMF, i.e., Light) informs the genes on how to respond, and how disease manifests 2:51 Autism and ADHD; Neurodiversity; and some problems in society 7:58 Core of Autism- B.3, and Donald Triplett example; B.2 and Social Communication 13:27 Autistic Phenotypes 19:01 ADHD Phenotypes 21:41 Specifiers and Lumping Contrasting Phenotypes 33:18 Medication and ODD (Oppositional Defiant Disorder) Rant 35:42 Autism conundrum with ADHD 38:45 Reviews/Ratings and Contact Info Hopp: https://www.hopp.bio/fromthespectrum X: https://twitter.com/rps47586 email: info.fromthespectrum@gmail.com | |||
| 23 Sep 2024 | Eye-Tracking as an Early Biomarker of Autism | 00:35:53 | |
In this episode, we discuss eye-tracking as an early biomarker for Autism. Eye-tracking, on infants, improve assessment outcomes at young ages, as young as 14-months-old. Adding biomarkers to the assessment process is valuable, and Autism research is beginning to offer more biomarkers. We've covered biomarkers in cellular respiration, serotonin, two studies on 6-week-olds- 1) predicted profound Autism with brain cortical organoids and 2) salience network connectivity. Today, we review four scientific papers on eye-tracking being added to the assessment process. A valuable consideration is the roles our eyes have on brain development, which we cover as well. Pierce et al 2019 https://pubmed.ncbi.nlm.nih.gov/31034004/ Wen et al 2022 https://www.nature.com/articles/s41598-022-08102-6 Keehn et al 2024 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818669 Early Autism Evaluation (EAE) https://medicine.iu.edu/expertise/indiana-health/access-to-care/autism/care Rudling et al 2024 https://journals.sagepub.com/doi/full/10.1177/13623613231203037 The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://www.youtube.com/watch?v=DAtmC-s1_e0 0:00 Intro; 2 studies on 6-week-olds; Eye Development and Brain Development, Opsins 5:23 OCT (Optical Coherence Tomography) scans and Brain predictors, Melanopsin 7:06 Melanin and Melanopsin through the body and biochemistry 8:39 Fruit Tree Example from Dr. Kruse 9:29 Eye-tracking and Autism as a Biomarker; Neuroplasticity- Human's capacity to think; Autism is NEW in human evolution 14:05 Social Attention; Oxytocin- magnocellular and parvocellular; Objects over People; Gaze Following 17:21 Gaze Attention 18:02 Joint Attention 19:12 Studies on Infants; Pierce et al, 2019 25:00 Wen et al, 2022 27:03 Keehn et al, 2024 and Early Autism Evaluations (EAE) 29:25 Rudling et al, 2024 32:15 Wrap-Up/Final Thoughts 34:55 Reviews/Ratings, Contact Info Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 26 Dec 2024 | This is my experience 3: Autism and Eye Contact | 00:14:01 | |
In this episode, we discuss some difficulties with eye contact for the Autistic phenotype. Sensory processing and the rate of information comes fast, and this provides additional energy for an already challenging and exhaustive task. Humans are constantly extracting physical phenomena from the environment (sensations) and we process this information to inform our nervous systems (perceptions). Specifically in this episode, we discuss the differences between listening and speaking. Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 31 Mar 2025 | Dr. Richard Frye, MD, PhD: All about Leucovorin & Benefits for the Autistic Phenotype | 01:02:07 | |
For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters. Dr. Frye shares many figures during the conversation so the listener can follow along. Dr. Richard Frye https://drfryemdphd.com Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter Neurological Health Foundation https://neurologicalhealth.org Healthy Child Guide https://neurologicalhealth.org/the-guide-5/ Daylight Computer Company https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3w use "autism" in the discount code for $25 coupon. This is the future of tech. Chroma Light Therapy https://getchroma.co/?ref=autism use "autism" for a 10% discount, 0:00 Dr. Richard Frye 0:58 Daylight Computer Company 5:17 Chroma Light Devices 8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa) 10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid) 14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase) 17:34 Cerebral Folate deficiency; BH4, Placenta & Womb 23:35 Folate deficiency & Autism 26:21 Clinical Studies & Data 29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!) 34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors 40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration 42:53 Folate Autoantibodies & Maternal Health & Markers 45:30 Studies & Behavioral outcomes; inflammation & thyroid findings 46:58 Neural development; Language connections, white matter tracts & distal connections 48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida 51:08 Preparing for pregnancy 53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness 59:32 Guidance & Support Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 01 May 2024 | What is Autism: Part 2 of Criteria A- Can you fit in, or Not? Are you like the so-called "normal" people, or Not? | 00:27:35 | |
Don't try to change an Autistic Person because they are "different" than you. In this episode, we explore more examples of Criteria A- Deficits in Social Communication and Interaction. Yay, more DSM-5-TR. Can you fit in, or not? Are you like the so-called "normal" people, or not? This episode is highlighted by personal experiences and examples. Plus, I have three jokes. The examples and episode is not exhaustive, however, I try to capture some of the conditions on the spectrum. There are lots of examples in our social world that just does not make sense, and we like to say, "that does not make sense." See Jack Kruse, Quantum Engineering 45 (0:00) Introduction; Crude Symptoms intend to capture the Spectrum; Can you fit in, or not? Are you like the so-called normal people, or not? (2:08) Facts and Reality over Make-Believe; Methodical and Seeing Bottlenecks in Society- I hate "that's just the way it is"; Traffic; Names- Landon?, Associations; Repeating things- I hate, "like I said." (7:09) "This does not make Sense"; Romantic Interests and Joke 1; Verbal Responses; Task-Switching from Fixated Interests; Sound Blends (11:44) Social Media Use- Strange; Eye-Contact- Humans say we need to do it, and We are not Birds; Leaving Social Gatherings and Joke 2, the gathering will gather without me (15:32) High-Fives = Stereotypy?; I hate Favors- favors create conflict; Henry David Thoreau; Self-Checkout Lanes and Autism, Neuroplasticity and Preference; Emotional Empathy (20:04) Debriefing and Understanding; Supplementing Relationships and Visual Thinking; Joke 3 and Fixated Interests and Perfect Intensity- the DSM can have it's "abnormal" label; Echolalia; Fitting In and Modeling as a Blueprint (26:03) Wrap-Up; Don't try to change an Autistic Person because They are "different" than you; Contact Information | |||
| 04 Nov 2024 | Autism and Relationships | 00:33:18 | |
Relationships are challenging. In this episode, we explore some of the Autistic phenotype challenges in relationships. We discuss symptoms from criteria A are external and criteria B are internal, and how criteria B complicates the symptoms in criteria A. In addition, Autism is a comparison to social-norms, and this is a problem. Some environments/relationships discussed include peer-to-peer, romantic, and parent-child. To begin, we explain the mechanisms behind the speaker-receiver and the use of conveying speech in socialness. Before we begin, we cover a brief explanation of Speaker-Receiver and human communication. Dr. Theresa Regan episode https://youtu.be/aUhIreFd5sw Autism and Adaptive Responses https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000658438095 What is Autism: Criteria A https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000651048705 The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273 (0:00) Intro; Speaker-Receiver explanation when conveying speech (3:55) Unpredicableness in socialness; black and white thinking and context-dependent and adaptive responses; Metabolic energy/resources; Oxytocin and Serotonin (7:10) Biology that gives us Autism gives us complications to socialness and relationships; Sex-differences and socialness (8:40) Criteria A is external, Criteria B is internal; Sensory-Processing (10:32) B.2 and B.3 implicates socialness (16:58) Direct social interactions (22:26) Autism versus social norms; Romantic relationships (26:51) Do Autistics outgrow Autism? (28:04) Parenting (31:30) Cohabitating (32:28) Wrap Up (32:45) Reviews/Ratings and contact info Links: hopp.bio/fromthespectrum X: https://twitter.com/rps47586 Email: info.fromthespectrum@gmail.com | |||
| 22 Mar 2024 | What is Autism: Restricted and Repetitive Behaviors | 00:38:47 | |
In this episode, we discuss criteria B from the DSM-5-TR. Criteria B are known as Restricted and Repetitive Behaviors. In addition, we discuss how criteria B implicates criteria A, or the social communication and interaction aspects of Autism. Peter Attia and Karl Deisseroth https://youtu.be/4oiKOX2lCmE?si=Ru7W7cPpDDxtE8Qr Future Treatment possibilities https://youtu.be/eeySrgKev2g?si=IbX5h6qG5ddBPeO5 Leo Kanner https://psycnet.apa.org/record/1943-03624-001 Meet My Autistic Brain Episode https://podcasts.apple.com/us/podcast/meet-my-autistic-brain/id1548001224?i=1000629007371 APA's DSM-5-TR https://www.psychiatry.org/psychiatrists/practice/dsm (But don't get hitch on this book) Time Scales Introduction (0:00) A Brief History (1:29) Similar Disorders (or Phenomena) (2:25) Levels of Autism; Criteria A and B; Superpowers and Superdeficits (5:16) Criteria B; B1 Stereotyped or Repetitive Motor Movements, Use of Objects, or Speech; Stimming; Echolalia Example (9:40) B2 Insistence on Sameness, Inflexible Adherence to Routines, or Ritualized Patterns of Verbal or Non-Verbal Behavior; Rigid Thinking Patterns and Gray Areas cause Problems; BEE MOVIE example (16:24) B3 Highly Restricted, Fixated Interests that are "Abnormal" in Intensity or Focus; Find your Interests and Superpowers and Do That; Vietnam War; Memorization, Accelerated Learning and Personal Example (22:37) B4 Hyper or Hyperactivity to Sensory Input or Unusual Interests in Sensory Aspects of the Environment; Complications with Eye-Contact and Keeping Up; Sensory Processing Phenomena; Visualization and the Eyes (32:47) | |||
| 20 Jan 2025 | Autism and Parkinson's | 00:38:04 | |
In this episode, we explore the connections between Autism and Parkinson's, focusing particularly on the basal ganglia and its substructures, notably the substantia nigra within the midbrain. We discuss how the substantia nigra, known for its high concentration of neuromelanin, plays a critical role in these disorders. The episode examines how neuromelanin, a dark pigment, not only absorbs all frequencies of light but also has antioxidant properties, binds metals, and acts as a neuroprotector. This discussion leads into the broader implications of environmental signals, particularly light, on human biology, touching on how modern changes in light exposure might affect these conditions. We examine the role of tyrosine in the synthesis of neuromelanin and its derivatives like dopamine, which are crucial for neural function. We look at how deficiencies or imbalances in these pathways could lead to the symptoms observed in Autism and Parkinson's, including motor function issues. The conversation also covers the direct and indirect pathways in the basal ganglia, explaining how these pathways facilitate or inhibit movement, respectively, and how their dysfunction can manifest in the characteristic motor symptoms of both disorders. We also touch on the significance of thyroid function, particularly the roles of T3 and T4 hormones, in brain development and neuron health, tying these elements back to the overarching theme of energy loss and transduction in both Autism and Parkinson's. Autism and Parkinson's are a lack of, or a loss of, energy. Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB: https://youtu.be/2-IA_gunXbw Tree comparison https://youtube.com/shorts/cLu53oVRRjI 0:00 Autism and Parkinson's; Basal Ganglia; Substantia Nigra; Neuromelanin; Internal Calculators 2:15 Tyrosine; Chromophores; Aromatic Amino Acids 3:50 Biological Energy; Mitochondria; Environmental Signals; Cytochrome C Oxidase; Autism Research Miss 6:20 Deep Brain Stimulation 6:48 Neuromelanin 9:02 Reverse Engineer ATPase 10:48 Tree Examples 11:45 Hypoxia and loss of energy & dopamine 12:26 Eyes, hair, & skin; RPE; efficiency & power; What is Light? 13:58 Light; Information & Energy; electromagnetic; wave-particle duality; sunlight versus artificial light 17:08 Thyroid; T3 & T4; Iodine 18:31 Roles of T3 23:00 Loss of energy in the womb & Autism research 25:00 Melanin + Water = Electrons 26:40 Basal Ganglia; "Motivations" & Movements; Direct Pathway 30:55 Indirect Pathway 32:52 Go, No-Go; Action selection, learning & habits; fine motor skills 34:18 Parkinson's and loss of timing & energy; modulating the two pathways & dopamine 37:07 Reviews/Ratings & contact info Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA TikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcast email: info.fromthespectrum@gmail.com | |||
| 03 Jun 2024 | Autism and Anxiety | 00:38:50 | |
In this episode, we discuss biology of anxiety, responses from anxiety, and common situations causing anxiety with Autism. The stress response system of the body is very finite and the nervous system reflexively responds based on what it knows. A few biological components of anxiety include the amygdala, bed nucleus of the stria terminalis (BNST), and the spine. Common responses to anxiety include avoidance, shifts in physiology, and valance, or how we feel about the situation. To end, we have a lengthy discussion on some common sources of anxiety. Biology and Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690364/ Deisseroth on Anxiety https://www.youtube.com/watch?v=UtCeIefq_PM Deisseroth on Autism and Anxiety https://www.youtube.com/watch?v=4oiKOX2lCmE Physiological Sighs https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00474-8 Jack Feldman https://bioscience.ucla.edu/people/jack-feldman/ David Spiegel https://med.stanford.edu/profiles/david-spiegel Joseph LeDoux https://as.nyu.edu/faculty/joseph-e-ledoux.html (0:00) Intro; Comorbid Tendency and the DSM (2:56) Anxiety's role (3:42) Biology and responses of Anxiety; Amygdala and Bed Nucleus of the Stria Terminalis; Avoidance, Physiology, Valance (7:48) Avoidance (Action)- Hypothalamus (9:11) Brief notes on Cortex (11:36) Back to the Hypothalamus (12:27) Physiology/Breathing (Body)- Parabrachial Nucleus; Physiological Sigh; Brainstem, Spine, and Body (17:48) Valance (Feelings)- Ventral Tegmental Area; direct or indirect exposure- it doesn't matter (20:00) Dopamine, Neuroplasticity, Side note on Testosterone, Multiple words have the same meaning (24:58) Common situations for Anxiety and Autism (35:58) Wrap Up, Reviews and Ratings, Contact Info | |||
| 21 Apr 2025 | Autism, Sensory Map & Serotonin | 00:31:52 | |
In this episode, we explore the critical role of serotonin in shaping sensory maps within the brain, a process vital for interpreting sensory input and navigating the world. Serotonin, a neurotransmitter and neuromodulator synthesized from the aromatic amino acid tryptophan, influences brain development by fine-tuning sensory systems. It modulates neuronal growth, synaptic connections, and plasticity, which are essential for creating accurate sensory maps in regions like the somatosensory cortex, visual cortex, and auditory cortex. These maps serve as blueprints for processing touch, vision, and sound, with serotonin regulating the pruning of connections in the thalamus and cortex to ensure precise sensory wiring. The episode also explores the broader biological implications of serotonin, emphasizing its role in both prenatal and postnatal development. Maternally derived serotonin, supplied via the placenta from the peripheral and enteric nervous systems, significantly influences fetal brain development, affecting proliferation, differentiation, and neuronal migration in sensory regions. Postnatally, serotonin continues to support sensory integration and mood regulation, working alongside oxytocin to facilitate bonding and stress buffering. We explore environmental factors, such as stress and modern lighting, on serotonin synthesis and the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol release. Daylight Computer Company use "autism" for $25 off at https://buy.daylightcomputer.com/RYAN03139 Chroma Iight Devices use "autism" for 10% discount at https://getchroma.co/?ref=autism 0:00 Chroma Light Devices, use "autism" for a 10% discount 03:12, Sensory Map Introduction and Serotonin’s Role, The episode introduces sensory maps, neural blueprints that help the brain interpret sensory inputs like touch, vision, and sound, 04:30, Serotonin’s Developmental Impact, Serotonin fine-tunes sensory systems by modulating neuronal growth, synaptic connections, and plasticity, creating precise sensory maps in the somatosensory, visual, and auditory cortices, 06:04, Serotonin and Sensory Processing (Visual), Serotonin, sensory processing in the visual cortex 08:29, Critical Periods and Neuroplasticity, sensory neurons and connections, pruning 10:00, Brain Regions and Serotonin’s Mechanisms, Serotonin, axonal guidance, neurogenesis, and migration via microtubules, brain-derived neurotrophic factor (BDNF), glutamate and GABA 12:55, Serotonin and Sensory Processing (Somatosensory), 13:51, Serotonin and Sensory Processing (Auditory), 14:52, Stress and the HPA Axis, Cortisol, circadian rhythms and cortisol spikes, modern environments, 16:16 Daylight Computer Company, use "autism" for a $25 discount 20:38, Maternal Serotonin and Prenatal Influence; Postnatal Serotonin and Oxytocin; Tryptophan Metabolism and Neurodevelopment, placenta, fetal brain development, proliferation, differentiation, and neuronal migration, serotonin, oxytocin & bonding and stress buffering, TPH1 and TPH2, kynurenine pathway Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 27 May 2024 | Autism and Employment | 00:32:20 | |
In this episode, we cover Autism and employment- some Superpowers and some Superdeficits. We discuss different types of work that are easier and fit our abilities and cover some challenges in the workplace. Some challenges include the social dynamic and being misunderstood, which are driving forces and sources of burnout and avoidance. Remember the metabolic "bank" account and the Excitation/Inhibition discussion. Brain Science and Sir Simon Baron-Cohen https://www.youtube.com/watch?v=gMxfq_QLuUU Brain Science Podcast https://www.youtube.com/@BrainSciencePodcast Pattern Seekers by Sir Simon Baron-Cohen https://www.amazon.com/Pattern-Seekers-Autism-Drives-Invention/dp/1541647149 Autistic Brain by Temple Grandin https://www.amazon.com/Autistic-Brain-Temple-Grandin/dp/0544227735 (0:00) Intro; Clip of Sir Simon Baron-Cohen on Brain Science with Dr. Ginger Campbell; Society's trap and time perception (6:20) Autism and awareness; Do others see or understand our abilities (9:12) The applying process and the interview- we hate look at me; Superdeficits are easier to remember; Honesty and accuracy and Employers don't have an accurate comparison (12:39) Understanding the Autistic Brain (14:25) Autistic Traits - some Superpowers (21:20) Autistic Traits - some Superdeficits (28:43) Good and Bad: Perfectionism- a tough balance (30:42) Do things that you can do, you will do, and you love to do; The Nervous System just does; See Temple Grandin and Sir Simon Baron-Cohen on types of employment for different types of Autistic Brains (31:38) Reviews and Ratings; Contact Information | |||
| 28 Oct 2024 | Dr. Theresa Regan, PhD & CAS: Understanding & Navigating Life as an Adult with Autism | 00:56:02 | |
For today's episode, we speak with Dr. Theresa Regan, PhD & CAS, about adolescents and adults with Autism. Dr. Regan is a neuropsychologist with over 25 years of experience serving adolescents, adults, and seniors in hospital settings. She is a Certified Autism Specialist and the Director of the OSF HealthCare Adult Diagnostic Autism Clinic. Dr. Regan has conducted over 1,000 assessments on adolescents and adults with Autism. Her expertise in brain-behavior relationships, adult and geriatric medical conditions, and autism has provided her with a unique set of qualifications for serving adults with autism. In addition to her clinical work, Dr. Regan is the author of Understanding Autism and the host of the podcast "Autism in the Adult." During the episode, Dr. Regan shares valuable tools and protocols for Autistics as we learn to navigate various responsibilities such as employment and relationships. Her role as a neuropsychologist offers her insights into alternative approaches beneficial for both Autistics and their friends, family, as well as in employment and educational settings. Dr. Theresa Regan https://www.adultandgeriatricautism.com OSF Healthcare https://www2.osfhealthcare.org/providers/theresa-regan-1602000 Autism in the Adult https://open.spotify.com/show/2POoTBvzgPr0yIkU7dmw2m?si=31381356153f4903&nd=1&dlsi=8f401dc6fce54bb5 Understanding Autism https://www.amazon.com/dp/B098KQKZT7?binding=kindle_edition&ref_=ast_author_bsi 0:00 Dr. Theresa Regan 1:42 Journey into Psychology and Autism 7:20 Understanding Autism in Adults 13:39 The Role of Self-Knowledge in Relationships 19:47 Challenges faced by Adults with Autism 25:32 Tools and Protocols for Regulation 31:48 Navigating Employment 37:54 The Importance of Self-Care and Balance 43:35 Resources and Future Direction 55:18 Reviews/Rating and Contact Info Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 05 Aug 2024 | Autism and Gastrointestinal Problems, and exploring how changes in Light have major implications | 00:39:13 | |
In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment. Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis. Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496 Su study: https://www.nature.com/articles/s41564-024-01739-1 Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/ Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9 Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/posts (0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions (3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems (6:22) POMC; HPA; Stress example (8:19) Common Autism problems in the GI (9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation (14:09) Melanin/POMC; Clock-Timing; Omentum (16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut (19:04) Vitamin D Receptors and more Clock-Timing (22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids (24:33) Avoiding UV Light implications (26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data (30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles (32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD (38:27) Reviews/Ratings and Contact Info | |||
| 23 Dec 2024 | Dr. Kristen Lyall, ScD: Modifiable Risk Factors & Autism | 00:57:12 | |
My guest today is Dr. Kristen Lyall, ScD. Dr. Lyall received a Doctor of Science in Epidemiology from Harvard School of Public Health. During her postdoctoral training, she received training in Nutrient Science at Harvard and Pediatric Epidemiology at UC-Davis MIND Institute's Autism Research Training Program. Currently, Dr. Lyall is an Associate Professor at Drexel University's A.J. Drexel Autism Institute – Modifiable Risk Factors Program. The overarching goal of the Modifiable Risk Factors program is to identify factors that can be changed to prevent or mitigate the adverse effects associated with Autism, thereby potentially improving outcomes for individuals and informing public health policy and practice. Dr. Lyall's expertise provides actionable tools for listeners to understand the environmental risks of Autism. By the end of the episode, we hope you gain insight into the identified modifiable risk factors for Autism. Dr. Kristen Lyall: https://drexel.edu/autisminstitute/about/our-team/all-staff/Kristen-Lyall/ Dr. Lyall publications link: https://pubmed.ncbi.nlm.nih.gov/?term=Kristen%20Lyall&sort=pubdate ECHO: https://echochildren.org Fish not Supplements: https://echochildren.org/research-summaries/fish-but-not-supplements-consumed-in-pregnancy-associated-with-lower-rates-of-autism-diagnosis-and-related-traits-echo-cohort-study-finds/ Other Resources: Biological Energy: Quantum Mechanisms, Water, DHA, and NF-kB (Autism is a loss of energy- electrons, photons, protons) 0:00 Dr. Kristen Lyall 2:30 Her Journey into Epidemiology & Autism 7:50 The Role of Epidemiology & Autism 12:15 Modifiable Risk Factors 17:32 Dietary Influences on Autism Risk; Eat more FISH (DHA!) 22:53 Assessing Exposure & Risk Factors 32:35 Immune & Hormonal Factors in Autism; Cytokines & Inflammation 39:17 The Impact of Acute Events during Pregnancy 44:45 Air Pollution & its Effects in Neurodevelopment; Oxidative Stress 48:14 Current & Future Research; ECHO & EARLI 56:34 Reviews/Ratings, Contact Info YouTube: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 30 Sep 2024 | Dr. Yehezkel Ben-Ari: Early Detection & Treatment of Autism & Questioning the Direction of Research | 00:56:05 | |
For today's episode, we discuss Autism with Dr. Yehezkel Ben-Ari. Dr. Ben-Ari is a pioneer in the field of human development with over five decades of academic and private research. He has over 520 publications with a strong passion for early detection and treatment of brain disorders. His work includes studying Human Development, Autism, Epilepsy, Parkinson's, and Brain Tumors. He is a leader in how science understands the roles GABA and Chloride during early development and the NCCK1 importer and KCC2 exporter during the Excitation/Inhibition shift. In 1986, he led INSERM Neurobiology and Pathophysiology of Development before shifting to Start-Up private investigation in 2008. He is the founder of Neurocholre, B & A Biomedical, B & A Oncomedical, INMED, and IBEN. Recently, Dr. Ben-Ari has made wonderful contributions towards Autism identification in the Placenta using the work of "Neuroarchaeology" and Machine Learning. Dr. Ben-Ari is the recipient of many awards including Grand Prix de l'INSERM, Grand Prix European Society of Epilepsy, and Grand Prix Gagne Van Heck Belgian National Scientific Research (FNRS), to name a few. His book, The First 1000 Days, will soon have an English version. Treating Autism with Bumetanide is available now. Dr. Yehezkel Ben-Ari https://www.inmed.fr/en/evenement/en-yehezkel-ben-ari Neurochlore https://www.neurochlore.fr/en/ Machine Learning https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994821/ Excitatory Actions of GABA https://www.nature.com/articles/nrn920 GABA https://journals.physiology.org/doi/full/10.1152/physrev.00017.2006 Neuro-Archaeology https://pubmed.ncbi.nlm.nih.gov/18951639/e 0:00 Dr. Yehezkel Ben-Ari 3:08 Understanding Autism: Origins and Early Detection 8:08 The Roles of Machine Learning Data Analysis in Identification 14:56 The Impact of Environment and Autism 23:18 Treatment Approaches and Efficacy, Bumetanide, and NKKC1 Inhibitors 31:04 Challenges in Autism Research, including the Genetic Debate, Medical Paradigms, and Decision-Makers 38:00 Future Direction and Innovative Research, Autism in the Placenta and the Environment during Pregnancy 53:56 Wrap Up / Reviews and Ratings, Contact Info Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 01 Apr 2024 | What is Autism: Deficits in Social Communication and Interaction | 00:32:49 | |
In today's episode, we discuss Criteria A in the DSM-5-TR, which involves social communication and interaction. We discuss various aspects of the social world including unpredictableness, sensory processing being overwhelmed from the rapid firehose of information, being a student in a classroom, empathy, and are Autistic's being changed instead of cultivated into their own unique gifts (or Superpowers). Autism and Empathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484273/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9804307/ More from CNTNAP-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/ https://www.cell.com/fulltext/S0092-8674(11)01010-5 Sir Simon Baron-Cohen https://www.psychol.cam.ac.uk/people/simon-baron-cohen Temple Grandin https://www.templegrandin.com Deisseroth on Socialness https://www.youtube.com/watch?v=gOWnf1BpkGs DSM (don't get hitched on this book) https://www.psychiatry.org/psychiatrists/practice/dsm (0:00) Introduction; (2:12) A1; don't change others just because; joining conversation; unpredictableness, protection, sensory processing and sounds blending; firehose of information; (15:11) A2; don't change others just because pt. 2 and ABA therapy; interests are easier for all; challenges in the classroom and mental effort; (21:09) A3; challenges with play as a child; strict rule adherence; imaginative play, even when good, is bad; fits and tantrums; speech and peers; empathy- emotional versus cognitive- ASD is better at emotional empathy; supplementing relationships later in life with small talk; relationships are hard! (31:32) Leo Kanner correction- Nervous Child, not Pathology- Pathology section in Nervous Child; (31:54) Final Thoughts; contact information and reaching out to me Email- info.fromthespectrum@gmail.com | |||
| 02 Jan 2025 | This is my experience 4: Autism and Others | 00:11:41 | |
Consider how the autistic phenotype might be judged. We spend more time in educational settings, but our interactions extend beyond these environments. Humans are social creatures, and we need to understand what individuals are trying to accomplish, especially in social settings. These two phenotypes show significant differences. | |||
| 19 May 2024 | Autism and Education | 00:40:53 | |
In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction. Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618 Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/ Thinking in Pictures https://www.grandin.com/inc/visual.thinking.html Autism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s (0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment (7:00) The Prescription Era; Medication first Paradigm (10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning; (13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not? (13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism; (14:39) Subject Switching and Criteria B conflict (17:14) If you have met one child with Autism, you have met one child with Autism (17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience; (23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics; (27:00) Art was fine, other subjects were not fine; Details to General versus General to Details; (27:58) High School personal experiences; Pathway to Success > General Education; (29:52) Did I graduate, or Not? (31:56) SAT (32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses) (36:34) Education Arrangement; Taking Notes is challenging (39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information | |||
| 03 Feb 2025 | Jill Escher: Understanding the Rates and Causes of Autism | 00:54:19 | |
In this episode, we explore the intricate world of autism research with Jill Escher, a dedicated philanthropist, lawyer, and parent to two Autistic young adults. Jill's journey into Autism advocacy was sparked by her children's diagnoses, with no prior family history, leading her to significant roles like president of the National Council on Severe Autism and leadership at the Autism Society in the San Francisco Bay Area. Through the Escher Fund for Autism, she examines the causes beyond genetics, investigating how environmental and biological factors might alter gene expression, contributing to Autism's heritability. Jill challenges the conventional genetic focus in Autism research, arguing that it fails to explain the increasing prevalence of Autism. She delves into complex topics like epigenetics and transcriptional regulation, proposing these might unlock the heritability puzzle of Autism. Her research includes looking at how factors like general anesthesia can affect future generations. Escher also discusses the hurdles in Autism research, including scientific dogma and the influence of the neurodiversity movement, urging for a more comprehensive approach to address what she sees as a looming national health crisis. Jill Escher https://www.jillescher.com Other Resources Autism and the Womb https://youtu.be/NOVp4mIroug The Relationship of the Placenta, Womb, and Development https://youtu.be/Mj5h5DOMcRw 0:00 Intro 1:18 Jill's Journey into Autism 4:25 Jill's Family & Autism 7:19 Research & Advocacy in Autism 10:19 Genetic & Heritability Explanation 13:05 Non-Genetic Factors; Epigenetics 21:08 Anesthesia; Germ Cell; Proliferation 26:29 Early Brain Development; Gene Expression; RNA; Molecular level 27:56 Research needs; Genetics & Dead End data; Society & Preparation of Prevalence 33:57 Rates of Autism & Future (& Current) Emergency 38:16 Vaccination 41:25 Migration; Excitation/Inhibition Imbalance; Functional Connectivity 48:02 Barriers in Autism; Jill's Contact Information 53:33 Reviews/Ratings Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 10 Jun 2024 | Autism and Adaptive Responses, and exploring the mPFC, ACC, and Insula | 00:36:33 | |
In this episode, we explore three regions associated with social awareness- the medial Prefrontal Cortex, the Anterior Cingulate Cortex, and the Insula. We review the functions of each, the interactions between each region, and the inputs and bi-directional connections to some crucial areas of the brain. In large part, we will review adaptive responses and cover some scientific literature on these regions and the implications to Autism. https://molecularautism.biomedcentral.com/articles/10.1186/s13229-024-00593-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354837/ https://www.nature.com/articles/s42003-024-06016-9 https://www.sciencedirect.com/science/article/pii/S0149763409000815?via%3Dihub#aep-section-id15 https://www.tandfonline.com/doi/full/10.1080/17470919.2023.2242095 https://www.sciencedirect.com/science/article/abs/pii/S0006322308011578 (0:00) Intro; mPFC, ACC, and Insula (3:26) mPFC, Excitation / Inhibition; CNTNAP2, SHANK3, Neuroligin, and PTEN (7:42) Functions of mPFC and a primary dive into Adaptive Responses; Neuromodulators (13:52) ACC (15:23) the mPFC and ACC lead the way (19:29) Scientific Studies on Theory of Mind Task and Sensory Processing (21:52) Insula (26:49) Scientific Study: Eye Gaze, Social Attention, Social Cognition, Observational Learning (30:11) Social and Nonsocial Studies- different areas for Autistics versus Non-Autistic (32:38) A study using 6-week-old Infants, attentional biases and sensorimotor and different brain areas (35:05) Wrap Up | |||
| 24 Jun 2024 | The Roles of Oxytocin and Vasopressin in the Autistic Phenotype | 00:39:16 | |
In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine. Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/ Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/ Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3Dtrue Magnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284 Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysis https://pubmed.ncbi.nlm.nih.gov/33400920/ Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/ (0:00) Intro; Oxytocin and Vasopressin; Episode Objectives (2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny) (4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic (6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light (8:58) Magnocellular and Parvocellular (12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions (22:20) Scientific Literatures (27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing (30:07) Oxytocin and Dopamine (31:08) Dopamine Receptors (31:37) GABA (33:57) Intranasal Oxytocin (36:08) Take aways from Intranasal Literature (37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration) email: info.fromthespectrum@gmail.com | |||
| 16 Jan 2025 | (Re-Release) Cause of Autism: Autism is a Modern Biological Adaptation to a Common Environmental Change- Light. | 01:16:12 | |
Autism just magically shows up. In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases. The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics. "... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse (Start here) Regenerative Health with Dr. Max Gulhane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uA Tetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMI Tetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4 Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXs Tryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079rev Autism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277 Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567 Regions of Interest: Atoms, Aromatic Amino Acids, Artificial Light, Chromophores, Cytochromes, Electromagnetic, Embryo, Folate Acid (and Folic Acid) Sunlight, Melanin (Neuromelanin), Melanocytes, Melanogenesis, Melanopsin, Mitochondria, Neuroectoderm, Neuroplasticity, Periodic Elements, Photoelectric Effect, Pro-opiomelanocortin (POMC) Proteins (wide-band gap semiconductors), Serotonin, Tryptophan Hydroxylase 1 and 2, Vitamins A, b9 (Folate/Folic Acids), B12, and D, Water X: https://twitter.com/rps47586 YT Email: info.fromthespectrum@gmail.com | |||
| 24 Mar 2025 | Nicole Rincon, PA-C: Various Biomarkers including Gastrointestinal Issues & Autism | 01:18:05 | |
Nicole Rincon https://www.nicolerincon.com Nicole's X https://x.com/NicoleRinconPA Rossignol Clinic https://rossignolmedicalcenter.com TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdf TACA Talks: https://www.nicolerincon.com/videos Publications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articles Nicole Episode 1 https://www.youtube.com/watch?v=BBkdgwVfcZI Nicole Episode 2 https://www.youtube.com/watch?v=auLReV0DHkQ Daylight Computer Company https://daylightcomputer.com use "autism" in the discount code for $25 coupon. This is the future of tech. Chroma Light Therapy https://getchroma.co use "autism" for a 10% discount, ***THIS IS NOT MEDICAL ADVICE*** 0:00 Nicole Rincon 1:10 Daylight Computer Company; DC-1 5:33 Pre-pregnancy checks; Vitamin D 8:37 MTHFR, Folate; Mitochondria; CPR, ESR, Inflammation 11:12 GI; CSA; Bacteria, Fungus, Parasites, Calprotectin; Zonalin; MS & Proteus Mirabilis 13:06 Organic Acid Test (OAT); Clostridia 15:24 MTHFR; C677, 1298; Folinic Acid 19:02 Folate's role in pregnancy and development; Critical info about types and duration 22:35 Cholesterol; Maternal & Child; Speech & Communication 25:06 Telepathy; Autism Rates 26:40 Dysbiosis; PCOS 29:30 Cholesterol ranges & symptoms; mood, irritability, cognition, aggression; Cortisol & Hormones 37:02 Dysbiosis symptoms; Self-Injurious, Posturing 41:08 Identifying symptoms in Non-Verbal; Self-Injurious 45:08 Importance of Gut Health & Checks; Vitamin D, Electrical Efficiency & Biological Energy 48:17 Autistics and pale skin; too many are pale; supplementing Vitamin D, K2; Brands 51:00 Proprietary blends warning; abbreviated doses; Fungal overgrowth, Yeast 55:49 "Binders;" Magnesium 61:00 Fungal Overgrowth & Autism; OAT, Clostridia, C. diff, aggression, self-injurious; Antibiotics & Probiotics 1:05:42 Telepathy Tapes, Autism, Water (Cytochrome C Oxidase), Coherence; Luc Montagier NOT Emilio Del Giudice; Distal Connections via Water and NOT axons; Outro Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 25 Nov 2024 | Part 1 Origins of Autism: Kanner kids | 00:36:54 | |
For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. (Part 2 on Asperger's "little professors" next). The two-part series intends to remember the phenotypes that appeared and became known as Autism. It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype. Leo Kanner: Autistic Disturbances of Affective Contact http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf 0:00 Intro 0:45 Erwin Schrödinger Quote; Quantum Physics; Missing link in Medicine 2:56 Kanner's Autistic Disturbances of Affective Contact; Demographics 3:52 Ages; Boys versus Girls; Phenotypes; Family History 6:26 Important consideration of Family History- electricity and nnEMF; general observation and important phenotypes 9:30 Anticipatory Motor Adjustment; Reflexes; Sensory and Adaptive Responses 13:32 Monotonous Repetitions; Sameness 15:26 Spelling and Language 18:20 Commands and Intrusions 18:57 Autism, not Autism and ADHD; Intense Fixations & Neuroplasticity; Default Mode Network; Sameness 24:00 Oblivious to Others; Inattentive- It's not ADHD, it's Autism 27:39 Changes & More on Sameness & Repetitions 30:10 Rote Memory; Gastrointestinal: Timelines and Milestones Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 16 Sep 2024 | Dr. Richard Frye, MD, PhD: Understanding the Roles and Sensitivity of Mitochondrial Functioning | 01:01:17 | |
For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters. He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders. Dr. Frye shares many figures during the conversation so the listener can follow along. Dr, Richard Frye https://drfryemdphd.com CV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdf Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3Dihub Autism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495 0:00 Dr. Richard Frye 6:13 Intro into mitochondria & energy production, various disease & dysfunction 11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics 16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain 20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine 26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria 30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation 34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression 42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis 45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm) 54:54 Future Research 59:58 Wrap up, Reviews/Ratings X: https://twitter.com/rps47586 | |||
| 07 Oct 2024 | Autism and the Default Mode Network | 00:33:44 | |
In this episode, we discuss Autism and the Default Mode Network. According to Lisa Feldman-Barrett, the Default Mode Network has many names because it has been discovered, named, rediscovered, and renamed many times. I do not disagree with the Science regarding Autism and the Default Mode Network. However, I disagree with the Interpretation of the Data. This IS our Default; our preferred state; the core of the Autistic Phenotype. After listening to this episode and understanding B.3, you can understand MOST of Autism. The only reason you cannot understand ALL of Autism from these two episodes is the amount of Phenotypes branching off of B.3 and our Default Mode. Autism IS preference for ALONENESS and SAMENESS. This minimizes sensations and distractions that interfere with our internal world. This state is NOT abnormal, how society interferes with it makes it abnormal. If you want more Autistics to ACHIEVE, then understand your interaction, interference, and interpretation of what YOU think Autism is, and that delta determines how much we are prevented in life. This, of course, becomes slightly different the more profound the Autistic Phenotype is with that specific person. In this episode, we will explore the different brain regions and the goals of these regions as it relates to our phenotypes. We will get into some "Thinking in Picture" and thinking styles. This will be a good time because of a future guest on From the Spectrum Podcast discussing Autism and Creativity. This is exciting for me. Lisa Feldman-Barrett Core System (DMN) https://lisafeldmanbarrett.com/2017/02/05/core-systems/ 0:41 Research at UT-Austin and the Importance of the INFRARED LIGHT study with Autism 5:48 Autism and the Default Mode Network (DMN); Buzzword in Science 7:19 Humans and our Prediction Machine and Sensory Processing; Innate or Learned; Oxytocin in the Autistic Phenotype; 9:36 History of DMN (from Lisa Feldman-Barrett) and the many names; Core Systems 11:58 medial Prefrontal Cortex (covered in many episodes); roles, E/I, connectivity, Internal Calculators 14:45 Posterior Cingulate Cortex (PCC); Self-Referential Thinking, Memory, Attention, Task-Switching and the harms of calling it ADHD 18:03 Angular Gyrus; Language, Sensory Processing "Bee Movie" example, Mental Images, Narratives, Empathy 21:12 Supplementing Relationships 23:36 Sensation-Perception 24:30 Precuneus; Self-Awareness, Episodic Memory, Prediction and Strategic Planning 25:52 Social Cognition; Social Cues and Skills 27:50 Autism and Anxiety- Avoidance, Breathing (Physiology), and Valence (how we feel) 28:48 Internal Calculators; Metabolic Bank Account and Demands 29:26 the DMN is a Misnomer and the Default (tendency, phenotype) of the Autistic 33:04 Reviews/Ratings, Contact Info X: https://twitter.com/rps47586 Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 29 Jul 2024 | Autism and the Womb, and expanding Artificial Light as a possible cause of Autism | 00:36:39 | |
In this episode, we explore Autism developing in the embryo. We will review a couple Scientific papers discussing specific time frames of development within the embryo based on each trimester and specific cellular abnormal processes occurring. We will connect previous biological and environmental components and how it influences the creation of Autism and previous episodes of From the Spectrum podcast. Remember in the Cause of Autism episode- Light, Water, Magnetism, Periodic Elements, Vitamins, and Proteins because they are involved. During the episode, we review risk-genes and how this could be the wrong direction for Autism research. As a counter, I provide where research and funding needs to focus- pregnancy. Cause of Autism https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496 Eric Courchesne https://profiles.ucsd.edu/eric.courchesne Prenatal Origins of ASD: The When, What, and How of ASD Development https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30051-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223620300515%3Fshowall%3Dtrue The ASD Living Biology: from cell proliferation to clinical phenotype https://www.nature.com/articles/s41380-018-0056-y Leukocytes and Melanin Pigmentation https://core.ac.uk/download/pdf/81931995.pdf mTOR and PTEN https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743803/ Cancer Drug for "Autism" https://neurosciencenews.com/asd-cognition-cancer-pharmacology-26481/ 0:00 Autism and the Embryo; Review of previous developmental milestones, and the processes and "ingredients" used in our Biology 5:45 Cellular processes; ASD Living Biology; becoming the complex living organism 8:17 1st Trimester: Proliferation, neurogenesis, migration 8:46 2nd Trimester: Neurite overgrowth, synaptogenesis and synaptic function 9:12 3rd Trimester: Neural networks 9:33 Epoch 1 and 2 13:04 Scientific Literature; risk-genes; send research and funding to pregnancy 17:57 Abnormal brain development in the embryo 21:39 Excitation and the risk-genes and consequences to the Nervous System 24:36 Be cautious of research direction; MEDICATION and MEDICAL PARADIGM RANT 29:32 Connecting Light and Abnormal Development across the Body- Example Melanin and Leukocytes 33:12 Recap on the Past 3 episodes 36:00 Reviews/Ratings and Contact Info X: https://twitter.com/rps47586 Facebook: https://www.facebook.com/fromthespectrum.podcast Email: info.fromthespectrum@gmail.com | |||
| 05 Apr 2024 | Common Genetic and Proteins Associated with Autism, and I play Tug-of-War with Barbed-Wire | 00:31:39 | |
In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary. Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdf 16p11.2, Serotonin, and Possible Social Deficit Rescues https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/ https://www.nature.com/articles/s41586-018-0416-4 https://www.nature.com/articles/s41386-021-01091-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/ Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/ Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/ SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3 Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/ https://www.sciencedirect.com/science/article/pii/S0092867414006734 (0:00) Introduction; Excitation and Inhibition; (3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should? (10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help; (13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch; (19:24) Back to 16p11.2 and Cortical Development; (22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability; (24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination; (25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC (29:25) Wrap Up and Contact Information email: info.fromthespectrum@gmail.com | |||
| 24 Feb 2025 | Part 1 Autism and Sensory Processing: Intro to Senses & Melanin | 00:20:02 | |
For today's episode, we discuss Autism and sensory processing. The episode expands on the concept of the mesencephalon (midbrain), touching on the superior and inferior colliculi, key regions that help extract and integrate sensory information. The role of melanin in sensory processing is highlighted, as it aids in signal transfer and increases efficiency in sensory organs, including the eyes, ears, and skin. The episode also connects these concepts to autism, noting that individuals with Autism often experience both hypersensitivity and hyposensitivity to sensory stimuli, affecting their interaction with the environment. The episode also dives into the biological foundations of sensory perception, focusing on the role of melanopsin and other chromophores in light absorption and how they influence wakefulness and sleep cycles. Additionally, we cover the auditory system, specifically how melanin in the cochlea contributes to hearing and how auditory processing can become overwhelmed in individuals with Autism, leading to sensory overload. The discussion then extends to the role of melanin in other systems, such as the gastrointestinal tract, and its connection to energy production and sensory perception. By exploring the pathophysiology of Autism at an early developmental stage, the episode emphasizes the need to investigate sensory processing and its integration across the nervous system to better understand Autism. Role of semiconductivity and ion transport in the electrical conduction of melanin https://pmc.ncbi.nlm.nih.gov/articles/PMC3384144/ Dr. Jack Kruse: QUANTUM ENGINEERING #53: WHY IS MELANIN ALWAYS FOUND BETWEEN YOUR SENSES & THE ENVIRONMENT? https://www.patreon.com/posts/quantum-53-why-83720421 Dr. Jack Kruse: QUANTUM ENGINEERING #45: AUTISM & MELANIN/MELANOPSIN: A MIGRATION PROBLEM https://www.patreon.com/c/DrJackKruse/posts 00:00 Autism and Sensory Processing 02:31 Mesencephalon’s Role; Melanopsin; Chromophores 05:02 Melanin in Sensory Systems 07:33 Light and Quantum Biology 10:04 Environmental Impact on Health; Hypo and Hypersensitivity 12:35 Energy and Mitochondria 15:06 Embryogenesis and Autism Origins; Neuralation, Neuroepithelial Cells 17:37 Autism Research 19:05 Reviews/Ratings & Contact Info Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 14 Apr 2025 | Tryptophan, Microtubulus, & Mitosis | 00:38:05 | |
This episode explores the critical role of tryptophan, an aromatic amino acid, in forming tubulin—the key protein building microtubules, which act as cellular "train tracks" for structure and movement. We delve into how microtubules drive mitosis, the process of cell division essential for growth and repair, and discuss tryptophan’s unique biochemical significance, including its single codon (UGG) and contributions to DNA methylation. We connect these cellular mechanisms to Autism, examining how microtubule disruptions may affect neuron proliferation and migration during prenatal development, potentially leading to sensory processing issues and altered connectivity. The episode highlights the intricate dance of cells in neural tube formation and emphasizes the need for deeper research into these upstream processes to uncover Autism’s developmental roots. YT video of tryptophan and microtubules https://youtu.be/AY6GmS_AePk?si=K_ZTy5RjLGkm1hGd Inner Cell Life video https://youtu.be/RrS2uROUjK4?si=DCHs927yteOZ00dW See Stuart Hameroff, Martin Picard, Michael Levin, Jack Kruse use "autism" for $25 off at https://buy.daylightcomputer.com/RYAN03139 use "autism" for 10% discount at https://getchroma.co/?ref=autism 00:00 Daylight Computer Company, use "autism" for $25 discount 04:22 tryptophan, aromatic amino acid, microtubules, mitosis; human biology, autism 04:44 tryptophan, UGG codon, methionine, SAM, MTHFR, folate, DNA methylation; upstream biology, RNA, DNA 06:04 microtubules, train tracks, mitosis, cell division, spindle, DNA separation; skin repair 06:55 tryptophan, tubulin, microtubules, mitosis, intracellular transport, cell shape; Autism research, upstream processes 9:25 Chroma Light Devices- Lights Designed for Humans, use "autism" for 10% discount 12:27 tryptophan fluorescence, mitosis, prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis; microtubules, chromosome movement, cell division, tissue repair 15:58 mitosis, neural tube, embryonic development, neuron proliferation, migration; Autism, brain size, connectivity 20:33 sensory processing, hyperconnectivity, synaptic pruning, microtubules; Autism, sensory sensitivities, cortical connections 25:06 excitation-inhibition imbalance, microtubules, environmental toxins, light exposure, fertilization, blastocyst; Autism, prenatal development, cell polarity 31:09 microtubules, neural tube, gastrulation, neurogenesis, synaptogenesis, ectoderm, mesoderm, endoderm; Autism, cell migration, 37:18 outro, reviews Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 12 Aug 2024 | Autism Research- if it is not finding the Cause, what is the purpose? | 00:30:14 | |
In this episode, we explore typical topics with Autism research and try to understand the purpose. Autism research is confounding, and maybe, lacks direction. We offer a research suggestion based on the most plausible cause of Autism- the new modern day environmental factor- Artificial Light. Remember, Autism just shows up, so it makes sense to send the mother and father back to an environment pre-Autism. Quantum Biology https://www.patreon.com/DrJackKruse/posts Photobiological Implications of Folate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/ B9 (folate) and B12 (cobalamin) are Photoreceptors, too. 0:00 Autism Research Direction and missing the beginning; Is it Click-Bait?; Confounding 3:30 Changes in Light and the Full Spectrum; the number of Genes involved with Autism Research 5:07 Genetic Variants, Copy Number, Duplications, Deletions 7:04 Gene-Envrionment Interaction; MTHFR; Methylation, Myelin 13:03 Brain Connectivity and Neurobiology 13:55 Socio-Environmental/Socioeconomic; Robert Sapolsky 14:25 Early Diagnosis and Bio-markers 14:47 Comorbid Conditions 16:05 Personalized Interventions 16:27 Medications and the PROFIT MILL 18:36 Today's Purpose; Parental Melanin, Artificial Light, and nnEMF 19:30 Research Idea with 3 Groups and Returning the Environment before Autism magically shows up 25:17 Shift-Work Warning 26:20 Back to Autism; Amish 29:07 Reviews/Ratings, Contact Info X: https://twitter.com/rps47586 Hopp: hopp.bio/fromthespectrum | |||
| 10 Mar 2025 | Autism, Neurulation, and Embryogenesis | 00:39:18 | |
For today's episode, we go into the science of embryogenesis, focusing on neurulation—the critical process where the neural tube forms, laying the groundwork for the central, peripheral, and enteric nervous systems. We discuss how disruptions in this early developmental stage, influenced by factors like folic acid metabolism, the sonic hedgehog pathway, and genes such as PTEN (P10), could shape the autistic phenotype. From cell proliferation to migration, we connect these biological processes to autism, exploring how environmental factors—like a pregnant mother’s exposure to artificial light versus sunlight—might alter developmental outcomes. This episode sets the stage for when the Autistic phenotype begins and for more detail on why the mesencephalon does not evolve into other cell types like the other three areas (prosencephalon, rhombencephalon, and spinal cord). Daylight Computer Company https://daylightcomputer.com use "autism" in the discount code for $25 coupon. This is the future of tech. 0:00 Daylight Computer Company 4:20 Neurulation; primary & secondary 6:26 Neural tube, MTHFR & Folate (Vitamin B9), DNA methylation 11:51 Neuroepithelial Cells; Neural Crest, Surface Ectoderm, Mesodermal 16:05 Environmental implications, proliferation, differentiation, and migration 18:45 PTEN 26:29 Modern Environments 28:00 What do you think light is? Autism is in the Womb 31:40 Hyper and Hypo-connectivity 34:40 some rants 35:51 Leo Kanner kid, Donald Tripplet; The Biology that gives us Autism allows us to be comfortable within ourselves; more rants, probably 37:59 Review/Ratings & Contact Info Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 10 May 2024 | What is Autism: Part 2 of Criteria B: Will the so-called normal people accept our "differences," or Not? | 00:23:54 | |
Criteria B is Autism. Hans Aspergers called the children with the syndrome "little professors." This is Autism. Our routines and fixated interests. Autism gives us the ability to be comfortable within ourselves, and this accelerates our abilities, our Superpowers. How will society handle these so-called "differences" and the conflict within the so-called "normal" people? In this episode, we expand to real-life examples of Criteria B components and review some personal experiences. Dopamine Nation (Pleasure and Pain SeeSaw) https://www.annalembke.com https://www.templegrandin.com/templegrandinbooks.html (0:00) Intro; Autism is Criteria B, how will society handle "differences," those differences create conflict in others, stimulus-response, conflict, and comfort (4:44) Routines (B2) and Plans, Exact Planning, Plan versus Actual Time and Execution, Reality meets our Visualized Thinking; Pleasure and Pain SeeSaw; More Relationship Struggles Implicated by Criteria B, (9:01) Punctual- for others and ourselves; Bias yourself into Action; Understanding the need for Breaks; Others take the easy way out; get Sunlight for our Biology (12:34) Personal Experience and a Glimpse into an Autistic Thought; Traffic Spacing (16:33) Researching Items and Fixated Interests (B3); personal experience; Hans Aspergers and his Little Professors- This is Autism! (20:40) Other examples- Pant Sizes and Alpha instead of Numerical, Restaurant Rant, Never Underestimate a Human's Capacity to Think; Don't try to change Autism because it is offends you- offends your expectations and beliefs (23:12) Reviews and Ratings and Contact Information | |||
| 05 Jan 2025 | A connection with Autism & Parkinson's: Thyroid | 00:08:42 | |
Understanding the roles of Thyroid with Autism & Parkinson's, and what is the missing link. Research misses the link. Do not rely on research to connect these conditions and point to the real cause. Both, Autism and Parkinson's, have two major factors, 1) clocked timing and 2) A loss of, or a lack of, energy. Two Questions are asked: 1) What do you think Neuromelanin is? 2) What do you think Light is? Maternal health and preconception testing for Autism https://youtube.com/shorts/C2yhaPoWdIY Iodine: https://youtube.com/shorts/q3dv-bslEwQ Thyroid hormones and Autism https://youtube.com/shorts/SRnDzn4Uvgc Impact of light on neurodevelopment and aging: Autism https://youtube.com/shorts/cLu53oVRRjI Basal Ganglia: our go no go area for learning & habits https://youtube.com/shorts/YWc8AxuGHHM Basal Ganglia: Motivation & Movements (you don't define Motivation, the nervous system does) https://youtube.com/shorts/5agnRtSC95U Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA TikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcast email: info.fromthespectrum@gmail.com | |||
| 14 Dec 2024 | This is my experience 1: Autism and Education Problem | 00:15:10 | |
These are comments about my opinion and experience with education- the classroom and the school day. There are many contrasts to the Autistic phenotype when it comes to the classroom and school day. Autism and Education https://youtu.be/zQpNtvS-tWw B.3 https://youtu.be/Ov_Bw--zzrQ Kanner Kids https://youtu.be/FjELhG5FKzs Asperger's Autistic Intelligence https://youtu.be/qygNL6wCrhg Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 06 Jan 2025 | The Autistic Phenotype & How Internal Calculators shape our Preference | 00:29:47 | |
The biology that gives us Autism allows us to be comfortable within ourselves. Our biology orients the Autistic towards our internal state. This is more comfortable for the Autistic in comparison to the outside world. In this episode, we cover brain regions, networks, and internal calculators. All humans use these biological calculators. However, based on the living organisms unique structure of brain regions and networks (connections), it is easy to understand why people are different. Epinephrine & Glia https://www.sciencedirect.com/science/article/pii/S009286741930621X Other Resources: Autism and Adaptive Responses https://youtu.be/Zj3_e6ZjCGk Autism and Default Mode Network https://youtu.be/9CqyH4woB34 Autism and Salience Network https://youtu.be/9ZbTztb3al8 Autism and B.3 https://youtu.be/Ov_Bw--zzrQ 00:00 - Introduction 00:42 - Biology and Autistic Comfort 03:05 - Salience Network Explanation 05:06 - Attention Management in Autism 08:35 - Default Mode Network in Autism 09:47 - Introducing Internal Calculators & Neuromodulators; Neuroplasticity 10:52 - Biological Responses in Autistic Behavior 14:02 - Effort and Energy: The Role of Internal Calculators; Calculator for Effort vs. Outcome 17:07 - Social Interaction and Energy Use 20:23 - Dopamine and Internal Calculators; Reward Prediction Error as an Internal Calculator 25:18 - Internal Calculators and Societal Norms; Impact of Social Expectations on Internal Calculators; Neuroplasticity Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA TikTok: (I don't love it) https://www.tiktok.com/@fromthespectrumpodcast email: info.fromthespectrum@gmail.com | |||
| 07 Apr 2025 | Autism, Circadian Rhythms & Protocols | 00:33:33 | |
In this episode, we navigate the fascinating world of circadian rhythms and their profound impact on our health. We cover essential biology and protocols for human health, Autism or not. We will discuss how these natural cycles of light and dark regulate our biology, from hormone production to mood and cellular function, and why disruptions—particularly from artificial light—are a growing concern in modern society. Highlighting the role of melanopsin, a blue light-absorbing protein discovered as recently as 1998, we explore how exposure to LED and tech light can throw off our internal clocks, a challenge especially relevant for those with autism who often struggle with circadian rhythm issues. Modern life has two problems: 1) removing ourselves from the full sun spectrum and 2) extending the day with artificial light at night. This, in large part, explains the origins of Autism: 1) a lack of biological energy (energy from the full sun spectrum during development- remember the episodes on neurulation, embryo and womb) and 2) improper clock-timing in our biology (in large part, this is why the gastrointestinal comorbid problem is heavily involved with Autism). We also introduce actionable protocols to reset and maintain a healthy circadian rhythm, whether you're autistic or not, emphasizing the critical role of sunlight at different times of day—morning, midday, and evening. We will discuss innovative solutions like the Daylight Computer, a blue light-free, flicker-free device designed with sensory-sensitive users in mind, and Chroma light devices that harness specific wavelengths to enhance well-being. Alongside these insights, we touch on historical and environmental factors, including a thought-provoking comparison to the Amish lifestyle, to underscore how our modern world might be influencing Autism rates and overall health. use "autism" for $25 off at https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3w use "autism" for 10% discount at https://getchroma.co/?ref=autism 00:00 Circadian rhythms introduced; blue light’s impact via melanopsin and Daylight Computer’s benefits. 00:42 Daylight Computer Company 5:00 Blue light’s harm, autism energy deficits, and artificial vs. natural light comparison. 08:01 Melanopsin’s role, modern light’s disruption, and historical autism link to artificial light. 12:01 Amish lifestyle comparison and modern environments’ effect on autism rates. 16:01 Morning sunlight protocol for circadian reset via SCN and melatonin timing. 20:01 Morning sun primacy; Non-Negotiable 21:23 Chroma light devices for health 24:33 Midday sun / UV light for longevity, evening sun’s role, and ranking sunlight importance. 28:01 Nighttime light management: avoid overhead lights, prefer candles/red lights, ensure dark sleep. 32:01 Maternal health benefits, reviews/ratings, and social media/podcast engagement Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 11 Nov 2024 | Nicole Rincon, PA-C: Insights into Pregnancy & Managing Autism Risks | 01:16:29 | |
For today's episode, Nicole Rincon, PA-C, returns to discuss the risks associated with Autism development. The conversation spans from before conception through to after birth. We'll explore how factors related to the mother can influence autism risk, and we'll look at specific tests and signs in the body (labs and biomarkers) that have been linked to Autism. Additionally, we'll cover environmental influences, dietary considerations, acute medical conditions and medications, seasonal patterns, and various other aspects to be mindful of. By the end of the episode, we hope you'll gain valuable insights to consider as you navigate pregnancy. Our goal is to educate listeners, especially those who are pregnant or planning to conceive, about these potential risk factors, equipping them with the knowledge to make informed decisions or to be more aware during these pivotal times. Nicole Rincon https://www.nicolerincon.com/nicole-rincon Rossignol Medical Center https://rossignolmedicalcenter.com/doctors/nicole-rincon/ TACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdf TACA Talks: https://www.nicolerincon.com/videos X: https://x.com/NicoleRinconPA Publications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articles Other Resources: Autism and the Embryo, and expanding Artificial Light as a possible cause of Autism https://www.youtube.com/watch?v=NOVp4mIroug (See 18:36) https://www.youtube.com/watch?v=OtA-aMN7ziY DISCLAIMER: THIS IS NOT MEDICAL ADVICE. 0:00 Nicole Rincon 1:00 Understanding Pre-Pregnancy Risks 4:02 Maternal Risks Factors for Autism 6:53 Environmental Factors for Autism 9:56 Alternatives to Common Medications 12:58 The Role of Light & Seasonal Factors 16:02 Serotonin & Autism 18:56 Inflammation & Mitochondria 22:08 Infections & Antibiotics 25:08 Lab Work & Biomarkers for Maternal Health 27:46 Tyrosine, Thyroid, & Iodine; Depression, Fatigue 31:07 Folate & Methylation in Pregnancy; Autoimmune; Pregnancy Complications 40:40 Amino Acids; Dietary Types & Autism; Personal Diets 49:00 Eating Seasonally & Locally 51:01 Post-Pregnancy Nutrition 54:00 Breastfeeding versus Formula Feeding; Environmental Factors & Toxins, Plastics, Water 1:00 The Role of Sunlight on Human Biology; Leptin & Hormones, Metabolism Accountant; Red Light 1:02 Sun and Sunscreen; Beta-Endorphins, Cannabinoids, Hormones 1:07 Concluding Thoughts on Health & Family Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 17 Feb 2025 | Autism and Eye Movements | 00:28:46 | |
In this episode, we discuss the connections between autism and eye movements, starting with the underappreciated role of eyes in human biology. We emphasize the significance of the retina, which is central to both image-forming and non-image-forming functions of vision. The discussion takes a turn towards how blind individuals also leverage their eyes for biological functions beyond sight, highlighting the pervasive influence of visual systems on human physiology. We explore the superior colliculus, an essential brain region that integrates sensory information from various sources, including vision, to direct our attention and reflexive responses. This area is crucial in understanding how sensory input differently, particularly in terms of attention bias and threat detection, which could explain some of the unique sensory experiences in Autism. We then touch upon the dorsal anterior cingulate cortex (dACC) and the roles in error detection, conflict monitoring, and effort evaluation. The dACC's involvement in these cognitive processes can provide insights into why certain social cues or environmental stimuli might be overwhelming or less salient for individuals on the spectrum. Additionally, the episode covers oxytocin, a hormone/neuropeptide involved in social bonding and emotional regulation, discussing its synthesis through magnocellular and parvocellular pathways in vision. What do you think oxytocin is doing here, for the cub and for you? https://www.reddit.com/r/NatureIsFuckingLit/comments/11q03yn/a_cub_puma_admiring_his_mother/?rdt=64743 Eye-Tracking as an Early Biomarker of Autism https://youtu.be/fJpIRHOZZO4 The Roles of Oxytocin and Vasopressin in the Autistic phenotype https://youtu.be/DAtmC-s1_e0 Mesencephalon https://en.wikipedia.org/wiki/Midbrain#:~:text=The%20midbrain%20or%20mesencephalon%20is,view%20of%20one%20cerebellar%20hemisphere. 00:00 - Introduction to Autism and Eye Movements; importance of eyes in biology, specifically mentioning the retina as a key player. 04:19 - Non-Image Functions and Master Clock; Melanopsin; SCN- master clock 08:13 - Eye Tracking and Autism Diagnosis; effectiveness at 14 months of age 12:23 - Biological Underpinnings of Eye Movements in Autism; dorsal anterior cingulate cortex (dACC), Superior Colliculus & Mesencephalon & sensory integration, attention in the context of Autism & brain development 16:48 - Sensory Integration & Superior Colliculus and Reflexive Responses & Biasing Attention. 20:58 - Developmental Aspects of Autism; embryonic stage before the central nervous system 25:11 - Vision and Autonomic Nervous Systemvision and breathing can influence stress and calmness & bidirectional connections 27:47 Reviews/Ratings and Contact Information Hopp: https://www.hopp.bio/fromthespectrum YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA email: info.fromthespectrum@gmail.com | |||
| 10 Apr 2025 | (Re-Release) The Roles of Oxytocin & Vasopressin in the Autistic Phenotype | 00:39:16 | |
In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine. Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/ Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/ Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3Dtrue Magnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284 Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysis https://pubmed.ncbi.nlm.nih.gov/33400920/ Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/ (0:00) Intro; Oxytocin and Vasopressin; Episode Objectives (2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny) (4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic (6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light (8:58) Magnocellular and Parvocellular (12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions (22:20) Scientific Literatures (27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing (30:07) Oxytocin and Dopamine (31:08) Dopamine Receptors (31:37) GABA (33:57) Intranasal Oxytocin (36:08) Take aways from Intranasal Literature (37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration) email: info.fromthespectrum@gmail.com | |||
| 22 Jul 2024 | Understanding the Rates of Autism: History, Classifications, Symptoms, Assessments, and Vaccines | 00:30:50 | |
In this episode, we explore some critical dates and understanding of Autism. We will time travel from 1911 to 2024 with a goal of understanding why the sharp increase in Autism diagnosis of late. We review the closeness of schizophrenia and the separation from schizophrenia. In addition, we will review Autism becoming a separate diagnosis in the DSMs from the 1980s and review the closeness of Vaccines and Assessment Standardization that parallels this time. Hopefully, some consideration about the rates of Autism are presented. Top Revenue Business Types- Not good. https://www.ibisworld.com/united-states/industry-trends/biggest-industries-by-revenue/ Bayh-Dole Act https://www.govinfo.gov/content/pkg/USCODE-2011-title35/html/USCODE-2011-title35-partII-chap18.htm How Autism became Autism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757918/#bibr56-0952695113484320 Eugon Bleuler DEMENTIA PRAECOX OR THE GROUP OF SCHIZOPHRENIAS https://philpapers.org/archive/BLEDPO-2.pdf Dr. Catherine Lord https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000659246090 (0:00) Intro, Classifications, Symptoms, Schizophrenia, DSM, Assessments, Vaccines and Bayh-Dole Act (3:21) 1911; Twilight Peaks; Psychoanalysis; Eugon Bleuler; Early Autism (10:37) 1959- Separating from Schizophrenia; Generational Lineage; Visual Imagery; Communication Problems are noticed (14:21) The DSM and the Development of Autism Diagnosis (17:32) Assessments becoming Standardized (20:22) Vaccines and the Bayh-Dole Act of 1980; Vaccine Schedule and Centralized Medicine and Revenue (25:06) 1980s-2000 emergence of Diagnosis and Assessments; Rates of Autism and Explainations (30:03) Reviews/Ratings and Contact Info X https://twitter.com/rps47586 Facebook https://www.facebook.com/fromthespectrum.podcast Email info.fromthespectrum@gmail.com | |||
| 14 Oct 2024 | J.D. Barker on Unlocking Autism's Superpowers: Creativity, Imagination & Intelligence | 00:54:46 | |
For today’s episode, we discuss Autism with J.D. Barker. J.D. is a New York Times and International Best-Selling Author. His debut novel, Forsaken, caught the attention of legendary Author, Stephen King, who allowed Barker to use one of his characters from Needful Things for Barker’s debut novel. His writing career took off with The Fourth Monkey, which drew widespread attention, leading to a series of auctions and pre-empts for its publishing rights globally. Barker's style often involves intricate plots that blend psychological depth with supernatural or crime elements, appealing to fans of both horror and thriller genres. Barker's work expanded when he was approached by Bram Stoker's family to co-author a prequel to Dracula, titled Dracul, utilizing previously unpublished notes by Stoker. Barker is a frequent co-author with legendary writer, James Patterson. Listen to how Barker can create such vivid imagination with the characters he creates. In addition, Barker shares critical information on how he navigates such a prolific and successful writing career, often managing many projects with great efficiency. This episode provides critical insights on how the Autistic Phenotype can strive with their unique superpowers. J.D. Barker https://jdbarker.com/books/heavy-are-the-stones/ J.D Barker and Christine Daigle's upcoming book in November, Heavy Are the Stones https://www.amazon.com/Heavy-Are-Stones-J-D-Barker-ebook/dp/B0D5RKLYPC/ref=sr_1_1?crid=2TRLN3LUMCEFA&dib=eyJ2IjoiMSJ9.FJj1OgrpA4iJyLa9pHJ9ZQ.GiVjyydPJtKVpMdmN0HupggAyTd0GcjUBJ9l5UUA6xM&dib_tag=se&keywords=heavy+are+the+stones+jd+barker&qid=1728672013&sprefix=jd+barker+heavy%2Caps%2C119&sr=8-1 J.D. Barker Books https://www.amazon.com/s?k=JD+Barker&crid=18DBO8RHA8T05&sprefix=jd+barker%2Caps%2C111&ref=nb_sb_noss_1 0:00 JD Barker 2:49 Early Years of Creativity, Books, & Understanding Autism; Trying to Fit-In; Following Rules, Black and White thinking versus Gray 11:43 Superpowers of Writing as a Reflection, Creativity, & Intelligence of the Inner World 15:00 Superpowers of Autism by Creating Catalogs: Patterns, Visual & Thinking in Pictures, & Creating Characters 20:42 Balancing Life with Autism 23:51 The Writing Bout; the Importance of Managing Energy to avoid Burnout 35:42 Focusing on the Process, not the Outcome 39:35 Stephen King's Blessing & Approval of Forsaken; the journey to meet King 41:44 James Patterson Collaborations 43:25 Bram Stoker & the Prequel to Dracula, Dracul; Superpower of the Autistic Brain example 46:11 Recognizing Autism in Children 49:11 Future work 52:42 Review/Ratings & Contact Info Hopp: https://www.hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 17 Jun 2024 | Dr. Catherine Lord: The Evolution of Autism Assessment, Challenges with Understanding the Spectrum of Autism, and Barriers in the Medical and Education Systems for Autism | 00:51:39 | |
In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment. Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems. Dr. Catherine Lord: https://www.semel.ucla.edu/autism/team/catherine-lord-phd https://childmind.org/bio/catherine-lord-phd/ https://labs.dgsom.ucla.edu/lord/pages/our_team The Lancet Commission https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01541-5/abstract The Lancet https://pubmed.ncbi.nlm.nih.gov/30078460/ Nature Reviews Disease Primers https://pubmed.ncbi.nlm.nih.gov/31949163/ Autism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638 The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/ (0:00) Intro (3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum (11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments (16:36) Gaps in the Autism Assessment (23:15) The Challenges with Understanding the Spectrum of Autism (29:32) Updates on the Lancet Commission and Profound Autism (35:19) Barriers with Autism and the Medical Field (39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests) (44:25) The Future of Autism and Helping Autistics Across the Life Span (51:03) Reviews/Ratings and Contact Info email: info.fromthespectrum@gmail.com | |||
| 12 May 2024 | Happy Mother's Day | 00:04:12 | |
There is no question Mothers that have children with Autism are incredible. You are loved and appreciated. | |||
| 19 Aug 2024 | B.3- This is Autism- Restricted, Fixated INTERESTS that are (Blank) in INTENSITY or FOCUS | 00:41:17 | |
Hans Asperger called the children "little professors"- This is Autism. In this episode, we explore criteria B.3, which is the core of Autism. Donald Triplett's father's first sentence to Leo Kanner- He seems self-satisfied. Hans Asperger https://psycnet.apa.org/record/1992-97284-002 Erwin Schrödinger https://en.wikipedia.org/wiki/Erwin_Schrödinger 0:00 Intro, Erwin Schrödinger and Leo Kanner; Light gives Life to Cells 2:29 B.3 5:15 Hans Asperger, Autist 7:19 Leo Kanner 8:31 Paths to Superpowers; Autism and Education; Medicine and Charles Sidney Burwell 13:50 Personal Experiences; Vietnam War; B.2 complications with B.3 15:22 Baseball Game and Probability 16:52 Adult Examples 17:55 1950s and Novel- example of Abnormal B.3; Thinking in Pictures and Supplementing Relationships 21:29 Disruptions from unplanned or outside interference; Medication Approach and Warning 23:36 Unusual Objects; ADHD prep; Finding interests in Life 26:31 Check-Out lanes and Autism; Self-Satisified- This is Autism 28:53 Circumscribed 31:36 Perseverative; The Nervous System 35:44 Bible; Inner-focus using B.3 as a Superpower and directing focus 39:16 Dogs and Snakes 39:50 Autistic Phenotype and B.3 at the Center 40:30 Reviews/Ratings and Contact Info X: https://twitter.com/rps47586 Hopp: https://hopp.bio/fromthespectrum email: info.fromthespectrum@gmail.com | |||
| 01 Jul 2024 | Autism and the Salience Network, and topics to prepare for a future episode about Sex-and-Diagnosis Differences and the Nucleus Accumbens (NAc) | 00:31:06 | |
We expand on a critical network discussed in the Autism and Adaptive Responses episode. The biology that gives us Autism, gives us a condition the outside world is chaotic. The trade off is our inner world is comfortable. See criteria B.3. The Salience Network is used to determine what we send our attention to as we orient ourselves with the outside world. You can see this in Autism versus Non-Autism. Autistics orient to single objects or single interests more than multiple objects or interests. That's Criteria B of Autism- Restricted, Repetitive Interests, Behaviors, or Activities. In Autism, the Salience Network connects to different regions compared to Non-Autism, and this is shown at Six-Weeks-Old. And, this implicates our Social Attention and Social Motivation. Remember Hans Aspergers called the children "little professors" because Autism provides a path of Superpowers based on those fixated interests that are "abnormal in intensity or focus." Covered Here. Also, we prepare for another discussion with a leading scientist from UCLA. Study on Six-Week-Old https://www.nature.com/articles/s42003-024-06016-9 GENDAAR https://pubmed.ncbi.nlm.nih.gov/34050743/ (0:00) Intro; Human's Capacity to Think; the Salience Network and the NAc (2:56) Insula (4:47) Defining the Salience Network and Salience Detection; getting "hijacked" and metabolic bank account (7:42) the Biology that gives us Autism causes a Chaotic outside world (9:00) Returning to Six-week-olds and the Salience Network (10:28) The Prefrontal Cortex and Human Cortex quiets things so we can properly evaluate things (13:52) Salience Connections of six-week-olds; social attention at 3-12 months; Autistic traits at 12 months (17:40) Sex-and-Diagnosis Differences; GENDAAR study using 8-17 year olds; Salience Network and Sensorimotor and Repetitive Behaviors (20:47) Second Key Finding and possible cause of Boys Bias with Autism (21:30) The Nucleus Accumbens- Reward Hub; Two Parts; shell and core (25:20) Preparing for a future episode (30:27) Reviews/Ratings and Contact Info Facebook https://www.facebook.com/fromthespectrum.podcast Email: info.fromthespectrum@gmail.com | |||