Big Picture Medicine (Mustafa Sultan, MD)

How can we design AI systems which remove human bias — rather than perpetuate it?

Ziad Obermeyer is Associate Professor and Blue Cross of California Distinguished Professor of Health Policy and Management at the Berkeley School of Public Health where he researchers and teaches on the intersection of machine learning and healthcare. Some of his most interesting research focuses on algorithmic bias, and how we can better build AI systems which avoid perpetuating and falling into these traps.

We talk about his fascinating story, how he created an AI algorithm which actually reduced bias and superseded human performance and some of the things he’s learnt along the way.

I hope you enjoy.

Prof Obermeyer's new initiative: Nightingale Open Source.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Ben Maruthappu is the the Co-founder and CEO of Cera Care; a digitally-enabled social care company which has raised over $400M dollars. He was made a Member of the Order of the British Empire in 2020.

0:00 Intro

0:47 Ben's story

6:10 How to have good ideas, at the right time

12:14 Good decisions Ben made with Cera to scale

21:07 Is the US greener pastures?

28:10 What healthtech can learn from fintech, ridesharing and food delivery

30:17 Anti-lessons from other industries

33:53 How do you stop driving becoming toxic

36:13 Are founders olympic athletes who don't deserve work-life balance?

38:31 Are you full of sh*t? What are your real motives?

41:19 Are successful founders happy people?

43:30 Mo money mo problems

46:51 The power of vulnerability vs the magnetism of certainty

52:21 Networking advice

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Daniel Kraft is a Stanford and Harvard-trained physician-scientist and inventor.  He serves as faculty chair for Medicine at Singularity University, is founder and chair of Exponential Medicine and has given four TED and two TEDMED talks.  

He’s also the inventor of the MarrowMiner, an FDA-approved device for the minimally invasive harvest of bone marrow, and founder of RegenMed Systems, a company developing technologies to enable stem cell-based regenerative therapies.  

He’s also served as an officer and flight surgeon with F-15 & F-16 fighter Squadrons. He has conducted research on aerospace medicine that was published with NASA, with whom he was a finalist for astronaut selection.  

We discuss why — despite reaching the fourth industrial revolution — healthcare seems to be stuck in the third or second. Dark horses in healthcare and some of the magic that has helped Daniel get to where he is today.   

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

According to Business Insider, Omada Health has quietly filed its S-1 to prepare for an IPO. Here's how Sean Duffy (CEO & Co-founder) built it.

0:00 Intro

0:17 Signing first customer

1:51 How to have good ideas in healthcare

4:00 Why metabolic health is a hard area to innovate in

5:18 What the MVP product looked like

11:16 Sean's secret tactics

14:55 Operational innovation as a differentiator

20:19 The Omada playbook — is it repeatable?

25:31 What boss moves have you made Sean?

29:37 The difference between good and great

32:29 Sean's best tip on selling in enterprise healthcare

33:35 Sean's advice to himself

Links

Omada Health: https://www.omadahealth.com

Dr Mustafa Sultan: ⁠⁠https://www.musty.io⁠

How can you extend life?

Professor Tom Kirkwood is Emeritus Professor at Newcastle University where he headed the Institute for Ageing and Health. He delivered the famous Reith Lectures and was awarded a CBE in 2009.

Perhaps most famously he put forward the ‘Disposable Soma Hypothesis’ — which postulates that the body has a limited budget of resources and energy. It must therefore make a compromise between living longer (longevity) and activities which will help it reproduce.

Interestingly, he also invented the INR in the 80s, which is a blood test used everyday by doctors to measure the clotting of a patient’s blood.

We talk about the disposable soma theory, how calorie restriction may extend lifespan, anti-ageing interventions which Prof Kirkwood finds interesting and how you would design a trial to show the efficacy of an anti ageing drug.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Rewind.ai just raised their Series A at a valuation of $350M. Investors include Andreesen Horowitz, Reddit’s Alexis Ohanian and OpenAI’s Sam Altman. Rewind sits on your computer and phone, and watches everything you do. Then you can ask it questions like: What was that really great Mediterranean recipe I looked at last month? Or I’ve got a call with a client next week, can you summarise every interaction I’ve had with them? But here’s where it becomes even weirder, powerful. They’ve announced the Rewind Pendant, a small audio recorder that sits on your chest. Rewind will be able to listen in to every conversation you have. You can ask it: What birthday present should I get for my partner? Did they drop any hints? Or how many arguments did we have last year? Pretty Black Mirror, right? Once you get over the ick however, you realise that this is correcting a lagging human function. Just like the cursed amongst us wear glasses; tools like Rewind will repair our broken memories. I spoke to Dan Siroker, Rewind’s founder— 0:00 Intro 1:54 Lessons from the Obama Campaign 3:28 How to use science to make your startup succeed 8:21 Privacy concerns 17:00 Rewind.ai as a brain-computer interface (BCI) 20:27 Forgetting is important for human wellbeing 22:26 Societal impacts of perfect memory 28:42 Rewind's tech stack 31:56 The existential risk of startups using GPT 35:21 D2C is harder than B2B 37:49 Leadership lessons 40:31 Perils of being a second time founder 46:44 Is any publicity good publicity? Links Rewind: https://www.rewind.ai/ Dan Siroker: https://twitter.com/dsiroker Dr Mustafa Sultan: https://www.musty.io/

Dr Keith Grimes is Clinical Digital Health & Innovation Director at Babylon Health — essentially, he teaches machines medicine. He’s also a General Practitioner with a special interest in Digital Health & Urgent Care, as well as founder of VR Doctors.

We talk about how to get into digital health as a doctor, the importance and unimportance of credentialism in the field, virtual reality and its applications to healthcare and Keith’s experiences with burnout.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 David Sinclair's controversial claim 1:39 Bull v bear case 6:23 David Sinclair's history of exaggerating and profiteering 8:34 Adam Neuman's involvement 11:40 Raising from unsophisticated investors 16:30 Why aren't big pharma interested in longevity? 22:45 Cynics are right, optimists get rich 25:26 Will a longevity drug be the most valuable therapeutic ever made 28:52 Feedback and outro David Sinclair's Tweet: https://twitter.com/davidasinclair/status/1679178670743732249?s=20 David Sinclair's Research Paper: https://www.aging-us.com/article/204896/text Elon Musk Tweet: https://twitter.com/davidasinclair/status/1679504700285104129?s=20 Dr Charles Brenner's Critique of Sinclair: https://twitter.com/CharlesMBrenner/status/1679213673771057152?s=20 Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

Ever wondered if astronauts are honest with their doctors? Or what it feels like to look out of the window at Earth?

Helen Sharman was the first British astronaut. Project Juno, was a joint Soviet-British programme which took Helen to the Mir Space Station. Helen was working as a research technologist for Mars (the confectionery company) before hearing about the opportunity on the radio.

We talked about the selection and training, what it’s like being in Space and the peculiar doctor-astronaut relationship.

How do you capitalise on a problem spanning 5% of Google searches?

Daniel Nathrath is the Co-founder and CEO of Ada Health; a self-assessment health app for patients.

Ada has 10 million users, 250,000 5-star ratings and they’ve raised just shy of $100M.

They’ve been backed by Philip Schindler (Google’s Chief Business Officer_ and William Tunstall-Pedoe; who created Amazon Alexa.

We discuss some of the details behind starting Ada and its initial reception from doctors, some of its successes and future direction and finally we talk about Daniel’s leadership philosophy and some of the things he’s learnt as Ada’s grown.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Susan Thomas trained as a Geriatrician, before joining Ernst and Young — eventually becoming Health and Sciences Lead Partner. In 2021 she left to become Clinical Director of Google Health UK.

We speak about her decision to leave a very lucrative and established role at EY to join Google Health, things she still misses about practicing Medicine, her approach to leadership and whether life gets better as you climb up the career ladder.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Jason Foster is the CEO of Ori Biotech; a cell and gene therapy company who have raised $139M in funding. He also sits on the boards of companies like GripAble, Credentially, and Auxita — and is an active angel investor.

0:00 Intro 

0:34 Jason's story 

5:31 What was your goal? 

6:39 When did you make it? 

8:31 Taking calculated risks in life 

10:48 Creating value vs chasing $$ 

12:15 When should you say no? 

16:39 How to coach people 

20:53 How to find a coach? 

23:37 How to do cold outreach 

27:16 Being a marketer and making it in biotech 

31:54 Introversion vs extroversion as a CEO/founder 

35:37 How to build professional relationships, Neurolinguistic Programming 

37:54 The founders first zeitgeist 

42:05 Managing your ego 

45:07 Disagreeable givers 

45:39 Why do media? 

46:29 Jason's grand theory 

51:59 Why are health/life sciences/biotech unique markets? 

55:28 Billion dollar health idea 1 

59:57 Billion dollar health idea 2 

1:04:00 Money and happiness 

1:07:50 Habits that have helped Jason

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you run a successful startup and code academy — all whilst completing your final year at Imperial College Medical School?

Harvinder Power is the co-founder and CEO of Motics — a company which brings physiotherapy into the digital era. He was the winner at the Kickstart Global Incubator, the McKinsey Venture Academy, the UCL VC Fund amongst many other accolades.

In this conversation, I tease out the trials and tribulations of a medical student entrepreneur. We talk about how he started Motics, how you convince patients to do something they're not doing and what medics can learn from engineers and marketers.

——————

Find Harvinder:

LinkedIn: https://www.linkedin.com/in/harvinder-power-70800b124/

Motics: https://www.motics.co.uk

CodeMD: https://www.codemd.co.uk

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Shivdev Rao is a Cardiologist and CEO/Co-founder of Abridge, who have raised over $22M.

Think of Abridge like an Alexa or Siri (or other voice assistant) that sits there whilst the physician and patient talk.

Instead of the physician writing notes during the consult, or staying late and charting — Abridge listens to the conversation and writes up the notes for them.

Similarly, instead of the patient frantically taking notes, or being bombarded with information — most of which they will forget — Abridge can send them an appropriately-pitched record of what was said, with key takeaways.

We talk about how Shiv built and grew this company, I ask him about the existential threat of LLMs like ChatGPT, how being in the intensive care unit is similar to building a startup, and how operating from a place of abundance is a key to success.

0:00 Intro

1:35 Shiv's story

8:50 Cross pollination as a tech CEO

12:02 Abridge, idea to execution

17:19 Possibilities with big data

19:53 Threat of LLMs like ChatGPT

23:52 How will Abridge fail?

25:22 How to stay focused

27:10 Leadership lessons

31:14 Habits that have helped Shiv

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Yusuf Sherwani is the Co-founder and CEO of QuitGenius — a digital clinic for addiction.

QuitGenius started life as a smoking cessation app, which Yusuf and his Co-founders created whilst at Imperial College Medical School. They have since expanded to the US and have raised just under $80M dollars.

We talk about the overnight success, and how it wasn’t really overnight. We talk a lot about decision making and useful mental models as a healthtech founder, and some of Yusuf’s failures and how he dealt with them.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Ivan Beckley is the Co-Founder of Suvera Health, a Google-backed virtual clinic which has raised over £6M in funding.  

0:00 Intro 

0:42 Ivan's Story 

5:14 Making Cash? 

7:07 Building Suvera 

10:19 Clinician-Product Fit 

11:58 Growing 

14:11 Experience of Feedback 

16:56 Lessons from Google 

19:47 Being Black in Tech 

23:20 Further Growth 

25:36 How Can Someone Move Faster Than You? 

28:45 Habits That Have Helped You?  

Ivan started Suvera whilst in Medical School at UCL — and has since expanded it from a basic app which could help GPs (Primary Care Physicians) complete medication reviews for their patients, to a full fledged virtual care platform for people with chronic illnesses.  

We dig deep into the lessons and habits that have helped Ivan grow Suvera — like how the obstacle is often the way — and how he leans into discomfort as a signal of future success. We speak about how he changed the minds of people who were sceptical of him, how someone building in healthcare today could move faster than him and what it’s like being a black man in healthtech.  

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you spend £16 billion to improve the world’s health?

That is the job of Sir Jeremy Farrar, the Director of the Wellcome Trust. In 1936, British pharmaceutical magnate Sir Henry Wellcome left his fortune to improve the world’s health. Now Sir Jeremy must work out what to do with £16 billion over the next decade — and where to most effectively spend it.

0:00 Intro 

0:47 The Third Role of Philanthropy 

2:53 Appetite for Risk 

5:38 What's Broken in Science Funding 

8:16 Generalism vs Specialism 

10:12 Why Are You Slow? 

14:49 Sexy vs Incremental 

17:04 How Much of Your Job Is Not Messing Things Up? 

19:35 Metrics for Philanthropy 

22:10 Playing the Long Game 

23:20 How Do You Know You're Doing a Good Job? 

28:05 First Become a King, Then a Philosopher (?) 

30:00 Habits That Have Helped In Your Career 

31:52 What's It Like Being Famous? 

33:28 Book Recommendations

By background he is a medical doctor and researcher, he has been named 12th in Fortune’s list of the world’s 50 greatest leaders, served in the UK’s SAGE group and was knighted in 2019 for his services to Global Health.

I ask him about how he spends that money, how to measure philanthropic impact, problems and opportunities within research funding and just how much of his job is just not messing things up.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Aengus Tran is the CEO of Harrison.ai — an Australian radiology AI startup who have raised $160M.

Harrison.ai just released their radiology foundation model, Harrison.rad.1. And it's really good.

0:00 Intro

2:25 I'm glad I didn't found my startup in the US

4:21 Partnering with a clinical operator is key

7:28 Scrappy stories from the early days

11:17 Where human radiologists outperform AI (zero-shot learning)

17:23 Big bets on the future of radiology

21:18 What happens when GPT-8 arrives?

25:29 How can AI reach suprahuman radiology performance?

28:58 What boss moves did you make?

Links

Harrison.ai: ⁠https://harrison.ai⁠

Dr Mustafa Sultan: ⁠https://www.musty.io⁠

Dr Andrew Vallance-Owen MBE was the Chief Medical Officer of Bupa between 1995–2012. He led work to bring patient reported outcomes into vogue in both the private and public sectors — and he was awarded an MBE in the 2014 Queen’s Birthday Honours. He now has a number of non-executive roles in healthcare, including as Chief Medical Officer of Medicover and on the boards of startups such as Testcard, Jude and Cerina.

We talk about his story, what he learnt about crisis management and the future role of private healthcare in the UK.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro

0:20 DEA comes after DTC health startups

3:18 How DTC health startups hacked customer retention

10:30 Will this kill the economics of D2C health startups?

12:57 How would we solve the problem

15:30 New LLM Paper in Nature

28:18 Audience feedback and outro

Links Mentioned

Cerebral Pushed ADHD Prescriptions And Failed To Report Data Breaches, Ex-Executive Alleges In Lawsuit (Forbes): https://www.forbes.com/sites/katiejennings/2022/04/28/cerebral-pushed-adhd-prescriptions-failed-to-report-data-breaches-ex-executive-alleges-in-lawsuit/DEA's proposed telehealth rules pull back COVID-era remote prescribing flexibilities: https://www.fiercehealthcare.com/telehealth/deas-proposed-telehealth-rules-tighten-covid-era-remote-prescribing-regulations

DEA extends telehealth prescribing flexibilities for 6 months: https://www.fiercehealthcare.com/health-tech/telehealth-providers-cheer-dea-moves-temporarily-extend-virtual-prescribing

Health system-scale language models are all-purpose prediction engines (Nature): https://www.nature.com/articles/s41586-023-06160-y

Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicine

Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a

People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health

Dr Mustafa Sultan: https://www.musty.io/

What does it take to become a great clinical academic?

Neil Sebire is a Professor of Pathology at the Great Ormond Street Hospital (GOSH) which is the country’s leading children’s research hospital as well as the Chief Clinical Data Officer at Health Data Research UK

He has loads and loads of other accolades including over 700 published papers, a H index of 88 and 32,000 citations so it’s always a privilege to get his thoughts.

This is the third podcast interview I’ve done with him. In Episode 2 of this podcast we talked about his story and informatics, then in Episode 17 we talked about how to be more effective at what you do as a Clinical Academic. This is a continuation of that last episode — in which I ask more about how to become a great Clinical Academic, how to make better decisions, how to play the long game, what’s worth pursuing and what’s best to ignore and lots more.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro

0:18 Ali Parsa's Immigrant Story

1:57 Picking a Problem That Was Too Big

4:15 The Supply Induced Demand Problem

5:55 The Unit Economics Problem

7:37 The Misaligned Incentives Problem

10:11 The Friction Problem

12:06 The First Mover Disadvantage

13:30 Raising Too Much Money

14:55 The SPAC Problem

17:40 The Pig With Lipstick Problem

22:07 Should Founders be Liberal with the Truth?

26:06 What Will the Next Health Unicorn Be?

Articles Mentioned

Babylon shareholders wiped out in restructuring deal: https://www.ft.com/content/ce42bcb7-d9ee-4667-910a-b6c7a419449b

Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a

People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health

Dr Mustafa Sultan: https://www.musty.io/

Dr Ignacio Medrano is the Founder of Savana (raised $44M dollars with over 100 employees). They use AI to unlock all the value out of clinical records and produce real world evidence.

0:00 Intro

0:34 Ignacio's story

1:30 Learnings from Neurology -> Entrepreneurship

3:27 How to build good health products/services

5:03 Downsides of being a doctor in health entrepreneurship

7:21 Just in case vs just in time learning

9:14 Perils of perfectionism in healthcare

12:34 Do you need to be a d**k to be a good leader?

14:27 Dunbar's number — leading bigger organisations

17:52 Differences in operating in Europe

20:12 Diagnostic medical AI is a waste of time

23:15 SWOT analysis of Savana

26:07 Threats to Savana — LLMs?

29:22 Being eccentric as a competitive advantage

31:09 Becoming a better speaker/storyteller

34:02 Declining Royal Academy of Sciences invite

36:24 Arrogance as a competitive advantage

38:48 Tribes — exclusion criteria importance

40:27 Billion $ Health Idea

41:38 Not watching TV as a competitive advantage

46:40 Outro

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr David Albert is a physician, inventor and serial entrepreneur.

He studied at both Harvard and Duke University Medical School. In 2001, he sold Data Critical to GE in a deal that valued Data Critical at $45M. Perhaps his Magnum Opus: AliveCor has raised over $150M and creates devices which are able to take ECGs or heart traces — from anywhere, at anytime. It’s newest innovation: The KardiaMobile Card is a credit card which can take an ECG — all whilst fitting into your wallet.

He also has over 75 patents and 100 scientific publications.

We speak about his formula and framework for innovating, lessons he’s learnt from his buddies such as Eric Topol and Vinod Khosla and whether everything in Medicine should be democratised.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Tina Woods is Director of the All Party Parliamentary Group for Longevity secretariat and CEO of Collider Health; who work with private, public and third sectors to accelerate innovation and transform health with sustainable impact at scale

She also leads the Open Life Data Framework and is the author of ‘Live Longer with AI: How artificial intelligence is helping us extend our healthspans and live better too'. She is also one of the authors of the influential ‘Levelling Up Health’ Report — which was supported by the Health Secretary and CMO.

Essentially, Tina is someone who has a truly big picture view of everything needed to add five years of healthy life expectancy while minimising health inequalities.

It’s easy for doctors and medical researchers to believe that their contributions are what will really move the needle in improving the world’s health — but really, we’re a small part of that picture.

We talk about what we can learn from fintech, whether government is useless and it’s the Elon Musks of the world who will drive change and how to spearhead a movement and really make things happen.

Tina is really fascinating — I hope you enjoy.

How can we use models to diagnose patients with rare diseases earlier?

Rudy Benfredj is Co-founder and CEO of Mendelian; who are helping doctors find and diagnose rare disease patients earlier.

Rare diseases are individually rare, but collectively quite common — they affect 1 in 17 people. With 8000+ rare diseases and some only affecting a handful of people across the globe — rare diseases take an average of 7 years to diagnose — which is dubbed the diagnostic odyssey.

Rudy is super interesting and I pick his brain about how artificial intelligence can be used help reduce the diagnostic odyssey in rare diseases. I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How can you use digital twins for faster clinical trials requiring fewer patients?

Dr Charles Fisher is the CEO and Founder of Unlearn.ai — which uses digital twins to reduce the number of patients required in clinical trials.

In a clinical trial, you usually have a treatment group who receive the drug/treatment, and a control group who receive a placebo. This means that a large number of patients need to be given a placebo — a fake or dummy version of the treatment with no therapeutic effect.

But using generative machine learning models, you can create a digital twin — a digital copy of a patient which might be able to emulate what would have happened to that patient if they’d received a placebo.

The promise of this technology is faster clinical trials, requiring fewer patients and producing better evidence.

Charles completed his PhD in Biophysics at Harvard and has raised $17M to date for Unlearn.ai. We talk about digital twins, viewing clinical trials with a biophysics lens and some of the challenges in getting this technology adopted.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What's it like running a company which has raised $90M?

Dr Ben Maruthappu is the co-founder and CEO of Cera Care — a technology enabled home care company.

I could speak about Ben’s achievements and accolades for hours, but to give you a whistle stop tour — he is a successful doctorpreneur, has published some very influential papers, and has worked in health policy — perhaps most notably — he was an advisor to Simon Stevens (CEO of NHS England).

Ben was awarded an MBE for services to Health and Care technology in the 2020 Queen’s New Year Honours List.

We talk about how Ben got to where he is along with what he learned at every step. We also dive quite deep into what it’s actually like to be CEO of such a large company. This is one of my favourite interviews — because Ben is incredibly candid and gives lots of useful advice. I hope you enjoy.

Find Ben

LinkedIn: https://www.linkedin.com/in/mahibenmaruthappu/

Cera Care: https://ceracare.co.uk

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

New series. We brainstorm billion $ health ideas.

Dr Chris Lovejoy is a Cambridge-trained Medical Doctor, Startup Founder and Data Scientist specialising in medical AI and health informatics. He has an IQ of between 4000–5000. Find out what he's working on at www.chrislovejoy.me.

0:00 Intro 

0:10 Generative AI  

28:55 DTC Weight Loss Clinics 

45:27 Cross Border Care

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

A paper published in the Lancet Digital Health found that less than 1% of clinical AI studies reviewed were of sufficient quality to have confidence in their results. This is a huge problem.

Dr Xiao Liu and Professor Alastair Denniston are part of the team who published that study — and to tackle this this problem — they have today published the first international standards for the reporting of clinical AI trials. These are called SPIRIT-AI and CONSORT-AI and have today been published in Nature Medicine, the Lancet Digital Health and the BMJ.

The goal of these guidelines is to improve the quality of clinical AI studies and increase their transparency.

We talk about the general quality problem in clinical AI research, we talk about their guidelines and some of the recommendations within them — and also about what the future of clinical AI validation looks like.

Papers

Nature Medicine

CONSORT-AI: https://doi.org/10.1038/s41591-020-1034-x

SPIRIT-AI: https://doi.org/10.1038/s41591-020-1037-7

The Lancet Digital Health

CONSORT-AI: http://www.thelancet.com/journals/landig/article/PIIS2589-7500(20)30218-1/fulltext

SPIRIT-AI: http://www.thelancet.com/journals/landig/article/PIIS2589-7500(20)30219-3/fulltext

BMJ

CONSORT-AI: https://www.bmj.com/content/370/bmj.m3164

SPIRIT-AI: https://www.bmj.com/content/370/bmj.m3210

Do you need to be a d**k to be a good leader? Here's what Dr Eric Topol said...

Dr Eric Topol is in the top 10 most cited doctors in the history of Medicine. He is a cardiologist, geneticist and digital medicine expert — and was commissioned by the UK’s Health Secretary to write a report to prepare the NHS for the digital future: The Topol Review.

Dr Topol has three best selling books on the future of Medicine: the Creative Destruction of Medicine, The Patient Will See you Now and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. 

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Konstantin started Kaia Health after paying $50,000 to cure his back pain at an elite pain rehab centre. It worked. But it seemed stupid. Why did this need to cost $50,000?

Kaia Health has since raised $125M and helped 625,000 users.

0:00 The 90 second story

1:22 How did he grow 20% every week?

2:15 Market timing is everything

7:43 We never put pressure on this making any money

10:51 How does an app cure back pain?

14:43 US vs Germany for digital health entrepreneurs

16:40 Go to market of Kaia Health

19:51 Why raise so much money?

24:57 The hero license

Links

Kaia Health: https://kaiahealth.com/

Dr Mustafa Sultan: https://www.musty.io/

Herman Pontzer is an Associate Professor of Evolutionary Anthropology at Duke University. He studies how our species’ deep past shapes our health and physiology today.

He is the author of Burn: New Science Reveals How Metabolism Shapes Your Body, Health, and Longevity.

In his book, he follows the Hadza community — a group of people who live in Tanzania and are relatively untouched by the modern sedentary lifestyle. They are hunter gatherers and are about 7 times more active than the average American.

You would expect then, that they must be burning thousands of more calories than the typical desk jockey — but they don’t. In fact, on average, they burn the same number of calories as the average American — even when we adjust for height and weight.

So what’s going on?

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Joshua Landy is a Canadian Intensive Care Doctor and Co-founder of Figure 1.

Figure 1 is sometimes described as Instagram for doctors — but it essentially allows healthcare professionals to share and discuss cases across the world.

It’s been used by over 40% of medical students in North America and it boasts over 3 million users. They’ve raised a total of $23.5 million dollars.

In this interview, we discuss the story of how Josh and his team built Figure 1, with a particular focus on how they grew and made money from it — as well as some of the big picture business decisions and directions they chose to go in.

Josh is extremely open and candid about the whole process — and I think you’ll particularly enjoy this interview if you’re thinking of building and growing your own healthcare startup.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Simon Eccles is the Chief Clinical Information Officer for Health and Care and Deputy CEO of NHS X. Amongst many responsibilities, he’s accountable for delivery of the Personal Health and Care 2020 programme, and the central expenditure for the NHS’s IT.

Whilst doing all of this, he also practices one day a week as a Consultant in Emergency Medicine.

He’s funny, he’s opinionated, he has a strong vision and he gives wonderful insight into what it’s like as a doctor policymaker. He talks about what he’s learned along the way, electronic health records, his views on blockchain and what he took away from his time at Saïd Business School at the University of Oxford.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Daniel Ek (Spotify Founder) has raised $65M for his new longevity startup: Neko Health. 0:00 What is Neko Health 2:18 They're doing nothing new 5:33 The bull case; why it's going to be huge 7:47 How are they possibly going to make money!? 18:30 Why aren't they doing full body MRI? 20:26 The bear case; why this will fail 25:13 Smells a bit hypey 29:15 The risks of longevity startups and early testing 35:41 The lowdown 37:47 Unexpected way of making $$$ 40:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

Where are the dark horses in medical AI? 🐴 

Professor Geraint Rees is the Dean of the Faculty of Life Sciences at UCL, Pro-Vice-Provost of AI and is also the director of UCL Business — its technology transfer arm. His research is primarily in cognitive neuroscience and he has been cited over 35,000 times with a h index of 93.

He sits at the intersection of academia, technology and business — so he has a really rich, birds eye perspective on MedTech.

I asked him which areas of AI in Medicine don’t get enough attention, the role of private companies in research and whether you need to work disproportionately hard to reach the upper echelons of a field.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Gian Seehra co-founded Pebble Labs and Trait Biosciences — having raised a total of $16M.

He was also a VC at Octopus Ventures, where he oversaw over $200M in funding. He led QuitGenius’s $12M Series A and also facilitated follow-on investments into companies such as Elvie, Big Health and Depop.

He now takes his knowledge built from being on the other side of the table — to coach entrepreneurs on how best to pitch and tell their story in order to raise money.

We discuss how to pitch to investors — good ways of doing so, but also common mistakes. We also discuss the core tenants of authenticity, logic, empathy and the X factor.

Essentially ways of sidestepping the monotony of “here are the 10 things investors want to see” — and instead really getting investors excited about what your vision and what you’re building — and hopefully throwing money at you.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Dafydd Loughran trained as a surgeon, before joining Babylon Health as an AI Clinician and then founding Concentric Health.

Concentric is digitising the consenting of patients prior to surgery. Essentially, bringing traditional paper consent forms into the 21st century. It started as a surgical consent aide-mémoire which Daf made as a Junior Doctor. He has since raised over $1M and Concentric has been adopted by NHS Trusts such as Imperial College and Chelsea and Westminster.

We talk about what it’s like to be CEO as an introvert, the challenges and opportunities in digitising consent and distributed leadership.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Jon Ronson is one of the most interesting people alive today — period. He’s the author of the Men Who Stare at Goats, So You’ve Been Publicly Shamed and The Psychopath Test — which spent 10 weeks on the New York Times bestseller list. His two Ted talks have been watched 20 million times, his books have been brought to life by George Clooney on the big screen, he has written screenplays for Netflix blah blah blah. Don’t believe me, listen to a pitch Jon wrote for ‘the Psychopath Test’. If you are not dying to hear what happens next — then, I don’t what to tell you…

0:00 Jon's pitch for the Psychopath Test

1:41 Jon's story

6:00 Strategies Jon used to bypass career gatekeepers

7:03 Would Jon Ronson be on Substack/podcasting

12:05 Does Jon Ronson pay attention to analytics? Post mortems

16:26 Startup philosophy applied to storytelling

19:08 Writing Advice from Tim Ferriss: Jon's opinion on doing interesting things to write better

24:59 Does Jon Ronson like being famous?

28:49 Analysis of 'The Psychopath Test' pitch to Ira Glass

37:30 Should you make decision based on what would be a good story

38:48 Jon Ronson's habits for creative success

Tom Wicher is CEO of DrDoctor — who have served over 20M patients and just raised £10M in their recent Series A round. But he spent the first 7 years bootstrapping, and diverged from his colleagues: Opting for the slow and steady gentle disruption path. Why?

0:00 Gentle disruption beats move fast and break things

3:36 Picking a problem in healthcare

5:44 Behavioural change theory

7:52 Stop treating patients like kids

10:30 Systems-level efficiency vs personalisation

13:02 Why don't patients show up for their appointments?

16:02 Overbooking: Learning from airlines

18:54 Carrot or stick: Motivating health behaviors

22:35 There's no big conspiracy in healthcare

26:24 PIFU model of patient booking

28:14 Sometime it's better not to empower patients

31:16 Habits/frameworks that have helped Tom succeed

Links

DrDoctor: https://www.drdoctor.co.uk/

Dr Mustafa Sultan: https://www.musty.io/

Professor Sir John Burn is Professor of Clinical Genetics at Newcastle University, a Non-Executive Director of NHS England and Vice Chairman of QuantumDx.

His story is fascinating and slightly unusual — because he began life from humble beginnings in a small village in the North East of England.

We talk about meritocracy, how to be a showman and why business and clinical academia are really very similar.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Molly Gilmartin is an Investment Manager at AlbionVC who manage over $1bn in assets and have invested in companies like Arecor, Healios and Pando.

She studied Medicine at Oxford, was a founding team member of Pando, Chief Commerical Officer of Induction Healthcare, a Consultant at McKinsey and now an Investor at AlbionVC.

We talk a lot about the psychology of communication, about strength-based feedback and radical candour, about how being inquisitive can get you very far, how energy is Molly’s superpower and lots of other frameworks that Molly finds useful in her career. We finish off by discussing her thesis on the emerging B2C2B model in healthcare.

This is a really value packed interview — I hope you enjoy.

Video Interview on Youtube.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What is VC and how do I raise it?

Dr Benedict Evans was set on becoming an orthopaedic surgeon, before he fell out of love with Medicine and saw a system in which he could make a positive change, at scale.

So he left his surgical training programme and joined McKinsey as a healthcare expert. He then worked as Associate Director of transformation at St Georges Hospital Trust in London before joining InHealth Ventures, which is a $50M early stage fund looking to invest in companies who can transform health outcomes across Europe and the US.

We talk about venture capital funding for doctorepreneurs, the mythos of McKinsey and Ben gives his most high yield advice for medics trying to get investment — which is gold.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Stephen Bourke is the co-founder of Echo; the online pharmacy. If you haven’t heard of Echo, it’s a bit like Deliveroo for your medication. It delivers repeat prescriptions to your door, free of charge and hassle-free. It was acquired by McKesson, the group who own Lloyds Pharmacy in 2019.

This is a really valuable conversation and Stephen is hilarious, honest and gives a tasty inside scoop into the world of online pharmacy. We talk about how to improve patient adherence, how Echo rose to the top despite not being the first company of its kind by a long shot, Stephen’s experience of making something cool but also accessible and how sometimes — you need to listen to all your friend’s advice, nod your head — and then ignore it all to take a big leap.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What's management consulting really like (all expensed trips to Vegas)!? How do you get your digital health solution into the NHS? And why do so many world-class performers have a performance/executive coach? This week's episode was a lot of fun, and you're going to love it if you want to hear advice from a super accomplished doctorpreneur.

Dr Charlotte Lee is the UK director at Big Health, who generate $10M in revenue and are helping millions achieve good mental health — digitally. They have 12 RCTs under their belt, and are most famous for Sleepio, which digitally delivers CBT for insomnia. In a former life, Charlotte was a medical doctor, Darzi Fellow and management consultant at KPMG.

——————

Find Charlotte 

LinkedIn: https://www.linkedin.com/in/charlottelee/

Twitter: https://twitter.com/DrChar_Lee

Big Health: https://www.bighealth.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Colin Espie is Professor of Sleep Medicine at Oxford University as well as Co-Founder and Chief Medical Officer of Big Health.

With insomnia, there are two mainstays of treatment. The first is medication or drugs, and the second is Cognitive Behavioural Therapy (or CBT). CBT has traditionally required face-to-face treatment from a psychologist, and can be difficult to access for patients in a constrained health service. Far easier, the criticism goes, to just give someone a pill.

Fundamentally, the problem is that prescription drugs are very scalable and relatively cheap. Face-to-face CBT on the other hand, is expensive and doesn’t scale well.

But new approaches package CBT into a digital platform or app — making it infinitely more scalable — and opening it up to many more patients.

Big Health are creators of a digital CBT program called Sleepio. Sleepio boasts the largest evidence base in digital mental health with 13 randomised controlled trials. Its parent company: Big Health has raised over $50M in funding.

We talk about digital therapy for sleep, as well as some debate about whether digital therapeutics require the same evidence as traditional medications.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Nikhil Patel is the Founder and CEO of Craniometrix, where they’re using innovative deep learning and digital health tools to diagnose Alzheimer’s Disease — and position themselves as the all-in-one Alzheimer’s care platform.

Nikhil studied Computer Science and Economics at Yale University, before launching Craniometrix — which was accepted into Y Combinator and have raised $6M in their seed round.

We talk about how he’s been able to build Craniometrix as a 22-year-old and get investors really excited about his vision, how a digital tool can unlock new levels of diagnostic ability and why Nikhil talks so fast.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Deena Shakir is a Partner at Lux Capital where she likes to invest in underdog entrepreneurs building breakthrough companies to accelerate advances and equity in human and population health. She’s led investments into companies like Maven Health; a unicorn in women’s and family health and SteadyMD; a telehealth company.

She has a very interesting background. She studied at Harvard and Georgetown’s School of Foreign Service. She was then a Presidential Management Fellow at the U.S. Department of State. She directed social impact investments at Google.Org. She was partner at GV (previously Google Ventures).

She's been named a "top 30 under 40 in healthcare" by Business Insider and “top 9 women to watch in venture capital" by The Wall Street Journal. She is a member of Fortune's Most Powerful Women and a lecturer at the Stanford Graduate School of Business.

We talk about her story, how her network is one of her most important assets and how much VC fits into philanthropy and doing good.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Peony Li is Founder and CEO at Jude — a company bringing bladder care into the mainstream.

She studied Economics at Cambridge, and has worked in Investment Banking, she worked as Head of Investments at Founders Factory, at Daye as Head of Operations before finally founding Jude and raising $2.5M.

We talk about the rosy picture of entrepreneurship versus the harsh reality, what it’s like to be a founder in a taboo industry and how optimism is a habit rather than something you’re born with.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How could better understanding your internal state improve your mental health?

Dr David Plans is a lecturer in Organisational Neuroscience and CEO of BioBeats; a company on a mission to free people from mental suffering. He’s completing his second PhD in Experimental Psychology at the University of Oxford and has raised over $6M to turn his academic research into a bustling company.

This is a really interesting conversation in which I’m completely out of my depth. We start by discussing David’s story and his view of hustle culture and how enhancing peoples’ interoception (which is loosely defined as understanding the internal state of your body) could improve their mental health.

Thank you to Elise Plans for the music you hear.

Find Dr David Plans

BioBeats: https://biobeats.com

David's Personal Website: http://www.davidplans.com

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What can 2 million retinal images and a machine-learning algorithm achieve? Early-detection of Alzheimers—at least that's what Dr Siegfried Wagner along with a team led by Dr Pearse Keane at the Moorfields Eye Hospital are working towards. 

We discuss the study at Moorfields, before going down a deep dive into how a relatively novel AI technique—Generative Adversarial Networks (GANs) can be used in Medicine. You may have seen a number of 'deep fakes' online, all made using GANs. But what legitimate uses do they have in Medicine and research? 

Mentioned Links

AlzEye Study: https://readingcentre.org/workstreams/artificial_intelligence_hub/alzeye/

Economist article on AlzEye: https://www.economist.com/science-and-technology/2019/12/18/a-system-based-on-ai-will-scan-the-retina-for-signs-of-alzheimers

Rotterdam Study: https://jamanetwork.com/journals/jamaneurology/fullarticle/2685868

Biobank Study: https://jamanetwork.com/journals/jamaneurology/fullarticle/2685869

Predicting age and sex from retinal fundus images: https://www.nature.com/articles/s41551-018-0195-0

Huma is about to reach a 1 billion dollar valuation, and is thriving while other digital health companies are dying. But what’s their secret sauce? Dan Vahdat is the Johns Hopkins dropout — who meticulously studied the successful business practices of big pharma, and using these, has created the 'soonicorn' digital health company that’s about to take over the world of remote patient monitoring and decentralised clinical trials. 0:00 Intro 1:11 Focusing on one big thing is bullsh*t 6:33 Lessons from Jony Ive 10:02 Healthtech infrastructure play 16:04 'Ownership is everything' discussion 20:18 If you maximise impact, commercial will come 24:00 Bad design hurts me 28:56 You don't need to try and inspire anyone 30:35 Are you full of sh*t? 32:27 How does your life change when you 'make it'? 36:50 Is studying successful people a waste of time? 39:28 Outro Podcast Links YouTube:    / @bigpicturemedicine   Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Mustafa Sultan: https://www.musty.io/ Dan Vahdat https://www.huma.com/

Max Parmentier is the CEO of Birdie, a Series B AgeTech startup who have raised $52M from the likes of Sofina, Omers Ventures and Index Ventures — and captured 10% of the UK market whilst currently scaling into Europe.

0:00 Intro

2:37 Shopify vs Amazon model in AgeTech

7:26 Product pivots: D2C never wins

11:56 Predictive AI AgeTech

13:58 I pitch an idea to Max

19:34 Lessons building Birdie

24:13 Leaving money on the table for purpose

Links

Birdie: https://www.birdie.care/

Dr Mustafa Sultan: https://www.musty.io/

Secrets, in Medicine, are a crime against humanity.

Dr Marcus Baw holds an unusual career as a GP, Emergency Physician and health hacker.

He makes a controversial claim: That we have an ethical duty to openly share our technological innovation — and anything short of this is a crime against humanity.

Links from Marcus

Digital Health Networks (CCIOs, CIOs, CSOs, Caldicott Guardians, Clinicians Who Code and more) discourse.digitalhealth.net

Open Health Hub - completely open discussion of all things open sourcey in healthcare https://openhealthhub.org/

My OSITOWFM blog https://medium.com/@marcus_baw/open-source-is-the-only-way-for-medicine-9e698de0447e

"Royal Colleges 3.0" https://marcus-baw.medium.com/royal-colleges-3-0-best-practice-as-code-7065bce821a7

Faculty of Clinical Informatics https://facultyofclinicalinformatics.org.uk/

RCGP Health Informatics Group (for GPs who are RCGP members only) - GP IT specialism https://hig.primary-care.org.uk

Chamberlen Forceps https://en.wikipedia.org/wiki/Obstetrical_forceps#History

Me on Twitter https://twitter.com/marcus_baw

Marcus's Website: https://pacharanero.github.io

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What can you learn from studying the brains of London cabbies?

Hugo Spiers is Professor of Cognitive Neuroscience at UCL. He studies how we remember, navigate and imagine space.

Some of his most interesting work has examined the brains of London cabbies who are required to learn the roads of London in painstaking detail. Now he leads the SeaHeroQuest project, in which his team are studying dementia using a mobile game.

We talk about his research — which in my opinion is fascinating but I delve a bit deeper — asking how ordinary people can themselves do fascinating research and not get stuck on mind numbingly boring projects. We speak about how he manages his time, how he sees work, mentorship and how he communicates and publicises his research so effectively.

I hope you enjoy.

Professor Spier's fiction book recommendation: Book of the New Sun by Gene Wolfe.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Adam Bataineh is a Longevity Doctor and Founder of Span Health (acquired by EightSleep). 

0:00 Intro 

0:15 Bryan Johnson's Blueprint Program 

12:32 Spotify's Daniel Ek Enters Healthcare 

22:27 VitaDAO Raises $4.1 (from Pfizer, Balaji Srinivasan...)

Ever waited months for a scan? Scan.com is making getting a scan as easy as booking an Uber. Behind the scenes of the disruptor changing medical imaging forever. 0:00 Race to the bottom? 1:34 AirBnB 11 star framework 9:57 Scan.com looks really easy to build — what's hard about it? 12:19 Lessons from working at Deliveroo 15:14 How do you make a lot of money? 19:41 Buying the domain name Scan.com 24:16 How to build a marketplace business 27:50 The perils of price transparency 30:36 What I would do to build a competitor 32:43 You need grit when building a health startup 35:46 Billion $ health ideas Podcast Links YouTube: https://www.youtube.com/channel/UCEzluDRmBTVby0WsO37V-xg Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Mustafa Sultan: https://www.musty.io/ Charlie Bullock: https://scan.com/

0:00 Intro

1:00 AI drug development

7:04 Big picture impact of AI drug development

9:14 Counterintuitive facts about drug development

11:06 Why can't we just make novel drugs with AI? Biology is hard

19:06 Microsoft's GPT-4 healthcare play

26:48 The hardest thing about health startups

31:49 Outro

Joined by: 

Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). 

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Professor Karl Friston is the most frequently cited neuroscientist in the world. Some of his most fascinating ideas centre around brain imaging, and of course, his infamous free energy principle — a grand unifying principle for cognitive science and biology.

Professor Friston is incredibly insightful and patient with my questions — which at times feel like a 5 year old playing with a grand chess master. We speak about consciousness, brain computer interfaces as well as Professor Friston’s story and advice for young academics. I try to deconstruct some of what his enabled him to put forward so many novel, impactful ideas.

I hope you enjoy.

I recommend listening to Lex Fridman’s interview of Professor Friston. Lex asks much more intelligent questions: https://lexfridman.com/karl-friston/

Secondly there’s a wonderful Wired article written by Shaun Raviv which you won’t be able to put down: https://www.wired.com/story/karl-friston-free-energy-principle-artificial-intelligence/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Adam Bataineh is a Longevity Doctor in the UK and Co-Founder of Span Health, a data-driven health coaching company which was built to increase human performance. Span helped members optimise sleep, nutrition, and exercise with science-based experiments.  It was acquired by Eight Sleep in 2022 for an undisclosed amount.   

Adam is really interesting because he’s a pioneer in Medicine. Longevity doesn’t really exist as a specialty in the UK but he’s creating his own niche. Improving the longevity and healthspan of people requires a broad and complete knowledge of human physiology, but it also requires a rich understanding of behavioural psychology and how to incentivise people to act today in a way that future them will be thankful.  

Or put another way, instead of putting out fires — doctors like Adam are trying to stop or at least delay the fires from happening in the first place.  We talk about Adam’s story and how he approached building Span, his approach to optimising longevity as well as some of his personal testing stack.  I hope you enjoy.

What are the realities of trying to procure PPE during a pandemic?

As the government has given the NHS a 'blank cheque' to fight against COVID-19 — why can't we just throw money at the PPE shortage? To get answers, I spoke to Dr Alisa Pearlstone — the project director at NHS Hero Support — a pop up, emergency PPE delivery service. They’ve teamed up with the Doctors Association and Letsbeatcovid to help fight the PPE shortage.

You can donate to NHS Hero Support at www.nhsherosupport.co.uk

Links to socials and the podcast newsletter can be found at: www.bigpicturemedicine.co.uk

Dr Michael Moor is a medical doctor doing his PhD in the Machine Learning and Computational Biology Lab at ETH Zurich.

Some of his most interesting research looks at predicting sepsis using machine learning approaches.

In case you’re unfamiliar, sepsis is a life threatening condition in which the body’s natural defences against an infection go into overdrive.

Mortality from septic shock can be up to 50% and every minute counts. In fact, for every hour treatment is delayed — mortality increases by 7.6%.

We started off by talking about a paper published in JAMA earlier this year. It assessed a popular sepsis prediction tool and found that it wasn’t very good. It was delivering so many false positives, that doctors would need to assess up to 109 patients flagged by the tool just to find one patient who was actually septic…

Michael's Preprint: Predicting Sepsis in Multi-site, Multi-national Intensive Care Cohorts Using Deep Learning

Michael Moor*, Nicolas Bennet∗, Drago Plecko∗, Max Horn∗,Bastian Rieck, Nicolai Meinshausen, Peter Bühlmann and Karsten Borgwardt.

JAMA 2021 Paper: External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients

Andrew Wong, Erkin Otles, Meng; John P. Donnelly, Andrew Krumm, Jeffrey Mccullough, Olivia Detroyer-cooley, Justin Pestrue, Mecon Marie Phillips, Judy Konye, Carleen Penoza, Muhammad Ghous, Karandeep Singh

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro

0:32 Why are VCs so unhappy?

2:18 What’s hard about being a VC?

3:56 Hustle culture, FOMO, always-on culture in VC

9:54 Is it ever easy to become rich?

12:22 It’s time to build in healthcare

15:31 Why is healthcare so hard for big tech?

17:31 Reasons why healthcare is easier than you think

21:04 Imposter syndrome for tech people entering healthcare

24:03 Would you build another healthcare startup?

25:12 Outro

Joined by:

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

How do you forge your own career path as a doctor?

Dr James Somauroo is a former anaesthetics/ICU doctor and the founder of the healthtech agency: somX. He writes for Forbes and is also the host of the Health-tech podcast — the biggest podcast in this space with listeners in over 100 countries.

Find Dr James Somauroo:

LinkedIn: https://www.linkedin.com/in/james-somauroo/

The Health-tech Podcast: https://podcasts.apple.com/gb/podcast/the-health-tech-podcast/id1438968893

somX: https://somx.co.uk

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Joe Stringer is a Partner at Octopus Ventures, one of the largest European Venture Capital firms with £1.8 billion under management.

He was Partner at Ernst & Young for 10 years, before leaving his cushy position to launch his own venture fund TenX Health. He then led Google Health in the UK before becoming Partner at Octopus Ventures.

We talk about his thesis on the future of health, the importance of hard work, grit and resilience, as well as building and managing relationships — in particular, trying not to be too British.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Do you want the granular step-by-step on how to launch your own MedTech startup?

Dr Krishan Ramdoo was an ENT Surgeon before co-founding TympaHealth; the world’s first all in one hearing health assessment system.

It’s essentially a digital otoscope (a scope that helps visualise inside the ear). Traditionally this was an analogue device, so no one else could see what you saw when you examined the ear — but with the Tympahealth system, you can see what the scope is looking at on your phone screen and then save that video to the patient’s records.

Unlike other similar devices, you can also use it to remove ear wax. It was the winner of the global UX design award and it’s seriously beautiful. You can go to tympahealth.com to see what it looks like.

TympaHealth have been very active in the battle against COVID, and the system has been trialled in the UCLH Trust in the country’s first tele-otology service.

This conversation is basically a deep dive into how Krishan has achieved what he has with TympaHealth. How he went from an idea in his head to his device being used by 1000s of patients as well as by Boots Hearing Care.

He’s a masterful storyteller — I hope you enjoy.

Find Krishan

TympaHealth: https://www.tympahealth.com

Krishan: https://www.linkedin.com/in/krishan-ramdoo-10086979/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Professor Shafi Ahmed is the world’s most watched surgeon. 

He has live-streamed operations using Google Glass, the Snapchat Spectacles — and even virtual reality technology. He’s really at the cutting edge of surgical innovation so it was a real privilege to speak to him.

He is the co-founder of Medical Realities; a company which specialises in surgical VR and AR tech. He has spoken at Wired Health, TEDx — he leads charity work in his native Bangladesh, he’s setting up a hospital of the future in Bolivia.

He has consulted for Google, PwC, Roche — he has advised the NHS on the Long Term Plan and was awarded the Future NHS Award by members of Parliament in 2018.

Find Professor Shafi Ahmed

Website: https://surgeon.ai

Twitter: https://twitter.com/ShafiAhmed5

Wired Health Talk: https://www.youtube.com/watch?v=vftA-_c1hYc

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Isn't it strange when everyone is raving about something — but you just — don't get it? That's the position Dr David Watkins (@DrMurphy11) found himself in in 2017.

Babylon had launched in the UK and promised to provide the powers of AI and telemedicine to the NHS. Babylon lets you video consult with a doctor, often on the same day. This was slightly controversial, but not compared to its other head.

Babylon had developed a sophisticated chatbot AI. After a game of 20 questions, the chatbot would suggest a diagnosis — although crucially (from a regulatory point of view) it wouldn't diagnose you.

You would then be directed (triaged) to appropriate care. Mild headache and flu-like symptoms? No problem! Stay at home and take paracetamol. One-sided weakness and slurring your words? Call 999 🚑

Dr Watkins installed the app and began testing it. The details of this testing are disputed — Babylon who refer to him as a 'troll' claim that he ran 2400 tests, Dr Watkins claims just hundreds.

More insidiously, Dr Watkins began to notice mistakes the chatbot was making — mistakes that no doctor would ever make. In one test, a 59-year old male smoker presents with central chest pain and nausea. Cookie-cutter symptoms of a heart attack, and he is duly warned.

The exact same situation but this time, the patient is a woman—

She is warned of a panic attack.

This week's podcast is the story of Dr Watkin's battle against Babylon Health.*

*Views expressed are those of Dr Watkins'*

This week's episode presents a single side of the story. For context, Babylon have done a lot of good in the world. They've brought affordable healthcare to Rwanda, created a clinical AI fellowship for doctors and generally offer lucrative remote working opportunities. 

——————

You can find Dr Watkins on Twitter @DrMurphy11. The title of this podcast episode is adapted from Dr Watkins' talk at the Royal Society of Medicine: "Cowboys and unicorns in #DigitalHealth — why validation is more important than valuation".

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How does a doctor start working for DeepMind/Google? 🤖 

Joe Ledsam is a Clinician Scientist at Google Japan after formerly working at DeepMind. He started his career off as a doctor, before migrating to research and eventually coming to his current position.

He’s worked on some of the most influential medical deep learning papers to date — published in the likes of Nature. For many nerds in Medicine — he’s living the dream. He was recommended to me by Pearse Keane who I spoke to on episode #10, who described him as simply exceptional.

We talk about how Joe started working for DeepMind and then Google, how he actively seeks out fields he’s uncomfortable with, how the Simpsons influenced his life philosophy, why he wakes up at 2am and what he believes — are the dark horses in this field.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How did a Paediatrician become the Managing Director of NHS Services at Babylon Health? 

We talk about Umang's advice for medics entering the business world, how to keep your clinical job, Babylon's validation and some incredible advice on crafting your own story.

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Find Dr Umang Patel:

LinkedIn: https://www.linkedin.com/in/drumangpatel/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro

0:54 Is AI Too Powerful?

17:59 Outlive, Peter Attia's New Longevity Bible

45:16 Why Are Americans Dying So Young?

Joined by: 

Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). 

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Dr Patrick Malone is an MD, as well as having a PhD in Neuroscience. His research focused on computational cognitive neuroscience and AI applications in radiology.

In 2020, he joined the investment team at Northpond Ventures where he invests in early-stage health-tech and deep-tech companies.

Patrick put together a viral Twitter thread on his transition from Medicine and Research into Venture Capital. In 40 tweets, he detailed his high yield advice on networking, communication and which skills are useful to develop. Essentially a Bible on some of the meta skills needed to have impact at scale in healthcare.

In this episode we discuss that thread — and I ask Patrick to expand on some of those meta skills, and we also talk about his thesis on the future of healthcare.

I think this is a super valuable interview — I hope you enjoy.

Video interview on YouTube.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Sandeep Bansal is the Founder and CEO of Medic Bleep; a pager replacement which raised over £3M. On top of that, he recently co-founded Carebyte Health — which offers personalised on-demand healthcare to Indians. He is also Faculty at Harvard Medical School and Barts.

This is a super interesting conversation in which Sandeep explains how he has partnered with some of India’s largest companies, to pay Indians to be healthy, how crypto fits into that mission and the fascinating new HealthTech/FinTech fusion model hitting emerging markets.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Numan have raised $70M+ and are set to become the biggest men's digital health startup, ever. Here's how. From their eccentric Founder. 0:00 Intro 0:42 Valuation 1:46 Lessons from Calm.com 4:49 Raising aggressively 7:35 Successful entrepreneurs are not hyper intelligent 10:38 When to quit 14:43 The Social R Number 18:14 Being nice gets you nowhere 22:24 Numan's marketing genius 38:09 What Adam Neumann got wrong 45:12 Narrative is like really important 49:13 Being honest about your motivations 52:59 Outro Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Mustafa Sultan: https://www.musty.io Sokratis Papafloratos: https://www.numan.com

Dr Stephanie Eltz is a Trauma Surgeon and CEO and Co-founder of Doctify, which is basically Yelp/Trustpilot for Doctors. They’ve raised >£22M dollar in funding to date.  

0:00 Intro 

0:41 Story 

2:34 Motivations 

3:47 Building Doctify 

8:25 Why do you have grit? Early childhood 

9:21 Are patient reviews good measures of a doctor? 

13:53 There is no growth hack 

16:34 How to stop reviews becoming a cesspit 

19:48 Monetising 

21:15 It's all about the destination 

22:46 Happiness as a founder 

24:31 Are you full of sh*t? 

26:48 First become a King, then a Philosopher 

28:10 Leadership and MBTI 29:28 Habits 

30:20 Insecurity and immigrant hustle 

33:16 Hustling 

35:00 You don't need to network 

36:17 Outro

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you enact systems-level change within the NHS?

Dr Owain Hughes was an ENT registrar before he decided to do something bold: fix NHS referrals. But systems-level solutions aren't as simple as just making an app... here's how Cinapsis did it.

Find Dr Owain Hughes:

Cinapsis: https://www.cinapsis.org

Twitter: https://www.linkedin.com/in/owainrhyshughes

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Niklas Rindtorff is a Physician-Scientist and one of the Pioneers in decentralised healthcare and life sciences.

He has an MD from Heidelberg University and he received his Master's Degree in Biomedical Informatics from Harvard Medical School as a Fulbright Scholar.

He is a founder of LabDAO, an online community of life scientists collaborating to increase the accessibility of life science tools both in the dry lab and wet lab. He’s also a Core Member of VitaDAO, a collective funding early stage longevity research.

DAOs are Decentralised Autonomous Organisations and a staple of the ongoing WEB3 revolution.

Investopedia defines DAOs as having no central governing body, every member within a DAO typically shares a common goal and attempts to act in the best interest of the entity. Popularized through cryptocurrency enthusiasts and blockchain technology, DAOs are used to make decisions in a bottom-up management approach.

Or as Niklas describes them, DAOs are basically a WhatsApp group chat with an attached cryptocurrency bank account.

In this conversation, I find out about how DAOs can be used in healthcare. From enabling rare disease research to fixing science’s publishing problems. I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Stephen Reeders founded MVM Partners in 1997. They invest in high growth businesses with bases in London and Boston. He’s had three different lives—

Firstly he obtained a BA in Natural Sciences from Cambridge, before getting his Medical Degree from Oxford and then training as a Doctor in some of the UK’s premier institutes such as John Radcliffe, Guys and Queen Square.

In part II, he became a Clinical Researcher across both Oxford and some of the US’s greatest research houses. For example, just in the infancy of his career, he discovered PKD1 — a gene linked to Polycystic Kidney Disease. The seminal paper was published in Nature in 1985.

Finally — in the third act, he moved into the world of business and investment — in which he tackled how to translate some of these discoveries into great businesses that could benefit people at scale. He was also the first investor and acting CEO of UpToDate.

In this interview, I try and unpack what made him able to excel in all three acts — and also, why a flourishing Doctor and Clinical Academic would move into the world of investment.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Thanks for listening.

Sir Bruce Keogh was National Medical Director for over a decade — leading clinical policy and strategy as well as being responsible for clinical leadership, quality and innovation. Sir Bruce was a celebrated cardiac surgeon prior to this, and during his tenure as Medical Director — he was most notably responsible for making clinical outcomes the currency of the NHS.

He has been declared the most influential clinician in the NHS by the Health Service Journal for three years and was appointed Knight Commander of the Order of the British Empire in 2003.

Honestly, I was nervous about speaking to someone of Sir Bruce’s stature. Fortunately, he is one of the kindest people I’ve interviewed — and I’m really happy to have captured his leadership philosophy, how he made decisions and decided what was important as Medical Director, and his life advice for medics with similar aspirations.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Why switch from Investment Banking to Medicine?

Dr Yusef Smith is a doctor, competitive gymnast and powerlifter. In a previous life, he was an investment banker before packing it in and training in Medicine. Whilst at Medical School he started Propane Fitness — the passive income from which has now overtaken his salary as a doctor.

Yusef is a friend and one of the most contemplative people I know. We talk about passive income, physical and mental health, tools for productivity and why Yusef went on a 10 day silent meditation retreat.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What do you when hospitals are running out of Personal Protective Equipment (PPE) and your colleagues are at risk?

Ryan and his team at Oxford Inspired have created a PPE mask out of scuba masks. They plan to deliver 3000 of these to the frontlines — but how do they work? And why are they having to step in?

You can donate to the fundraiser at: www.oxford-inspired.com and you can find Ryan's innovation journal of the future at www.weshare.healthcare

More about reverse innovation: https://www.bmj.com/content/367/bmj.l6205

Mehdi Yacoubi is Co-Founder and CEO of Vital — where they are building the Strava for Health. Essentially a service which incorporates data from wearables (your HRV, your glucose levels, your sleep) and pulls these altogether into a community, also providing clear analytics and recommendations — ultimately transforming how we think about our own health.

In 2021, Vital raised an undisclosed amount in a pre-seed round led by JME Ventures.

Mehdi is also the author of the newsletter the Long Game which is probably in my top 2 or 3 newsletters I consume. He writes incredibly thoughtful and detailed articles on health optimisation, longevity, fasting, fitness, nutrition, the future of aging & self-experimentation.

In this conversation, we essentially break down play by play how to use data and metrics to improve health behaviours — and how it’s not as easy as just give them the data and they will improve their health behaviours. Really there’s so much more to positively influencing our behaviour and psychology — and it’s really fascinating to discuss with someone whose ideas and thoughts I have so much admiration for.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What does it mean to become addicted to failure?

Dr Mala Mawkin is a Doctor, Head of Market Development at Cellen and hosts the Royal Society of Medicine’s Digital Health Podcast.

She's also been featured on Forbes 30 under 30 and Vogue UK’s Top 10 Rising Female Stars — impressive — considering she graduated from Medical School just two years ago.

We talk about persistence, chasing failure, leaving Medicine and what it’s like as a woman in healthtech.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Imran Mahmud studied Medicine at Oxford, before studying Public Health at Harvard on a Fulbright Scholarship. He then ranked first in the country and entered the Ophthalmology training programme which he then promptly left, joining McKinsey. In 2018 he co-founded NYE Health, raising over £4M. He is now a startup advisor, angel investor and consultant on digital health topics.

We speak about leaving Medicine and if the grass is really greener on the other side, how to network, effective decision making and lots more. I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

What's the difference between UK and US medical training?

Dr Ikram Haq trained at Imperial College Medical School, interning at McKinsey before starting training at the Mayo Clinic in the US — considered one of the best hospitals in the world.

We talk about the difference between US and UK medical training, how Ikram got to where he is — covering both the high level philosophies and granular details — as well as how he deals with failure.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Elina Berglund is the CEO/Co-founder of Natural Cycles, which she has grown to 2M users. When every other app seemed to be free — she made a brave decision: She charged her users a monthly fee. And it worked...

0:57 - The Birth of Natural Cycles 2:57 - The Decision to Charge from the Start 3:47 - Building Trust Through Pricing 4:23 - From Personal Struggles to Public Solution 5:52 - Creating the Fail-Safe Algorithm 6:32 - Collaboration with CERN Colleagues 7:13 - The Human Body: Complex Beyond Measure 8:37 - The Promise and Challenge of Wearables 10:16 - Understanding User Behavior 11:04 - Gaining Regulatory Approval 12:26 - Secrets to Growth and Marketing 13:43 - The Challenge of Direct-to-Consumer Healthcare 16:02 - Data-Driven Decision Making 17:13 - Instincts Versus Data 19:01 - Staying Honest with Data 21:20 - Calibrating Communication for Investors 22:30 - Benefits of Being Profitable 24:08 - Data as a Superpower 24:59 - Overcoming Negative PR 27:13 - Future of Contraception 29:30 - Impact of Roe v. Wade Overturning

Links

Natural Cycles: https://www.naturalcycles.com/

Dr Mustafa Sultan: https://www.musty.io/

Morgan Cheatham is Vice President at Bessemer Ventures and an MD Student at Brown. He was Forbes30u30 for Venture Capital.

Morgan is a super smart guy who has lots of interesting theses and billion dollar ideas in health and life sciences, including ones in generative AI and biosecurity.

We also spend lot of time talking about relationship-building, networking and using the content game to make it in health.

0:00 Intro

0:31 Relationship building

1:54 What you can offer people

3:33 Having strong beliefs as a competitive advantage

4:02 How to develop unique theses in health

6:56 How to avoid just following trends and have original ideas

10:09 How to network

13:15 How to use content as a USP in health

19:58 Is content-creation for charlatans?

21:54 Predictions in health: Generative AI + BioSecurity

27:19 BioSecurity Idea

29:27 Billion $ Health Ideas 

31:43 Generative AI in healthcare

34:11 Book recommendations

37:06 Habits

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Ali has reached medic nirvana. He has over 770,000 YouTube subscribers, a successful business (6med), one of my favourite podcasts (Not Overthinking It) and is an all round wise man. He's managed to diversify so that Medicine is not his livelihood — it's a hobby he can approach on his own terms.

His content started with advice for prospective and fledgling medical students — although he has now expanded into tech, productivity and entrepreneurship. You're going to love this episode if you're a wannabe creative, entrepreneur or want to get out of Medicine's rat race and play your own game.

I've been chasing Ali for a long time because I knew he would provide so much value. He doesn't disappoint.

——————

Find Ali

Website/Newsletter: https://aliabdaal.com

YouTube: https://www.youtube.com/user/Sepharoth64/videos

Not Overthinking It Podcast: https://www.notoverthinking.com

Instagram: @AliAbdaal // Twitter @AliAbdaal

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Imran Mahmud studied Medicine at Oxford, before studying Public Health at Harvard on a Fulbright Scholarship. He then ranked first in the country entering the Ophthalmology training programme — promptly leaving and joining McKinsey. In 2018 he co-founded NYE Health, raising over £4M. He is now a startup advisor, angel investor, digital health consultant and content creator.

We speak about angel investing — which was traditionally a way in which high net worth individuals could invest in small startups — but is now becoming possible for many more people. We speak about the digital nomad post-economic lifestyle — and whether doing whatever you want, wherever you want actually makes you happy. And one of my favourite one of Imran’s principles: To be interesting, do interesting things.

I hope you enjoy.

0:00 Intro 

0:49 How to angel invest 

06:47 Can anyone angel invest? 

10:46 To be interesting, do interesting things 

12:43 Does money buy happiness? 

16:40 Does freedom make you happy? 

19:47 Is homeschooling weird? 

23:52 Why are successful people making content? 

29:20 Content creation as a competitive advantage 

32:07 Better to know how to code or know how to make content? 

33:19 Managing your ego 

35:43 Habits that have helped you in your career?

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How can you become a superconnector?

Will Gibbs leads the Future of Health team at Octopus Ventures; one of the largest Venture Capital firms in Europe — with over £1.3bn under management.

Will studied Classic Archaeology and Ancient History at Oxford, before trying his hand at pig farming and then becoming an investor at Octopus.

We talk about the pros and cons of being a doctorpreneur, being right when others are wrong and how to become a superconnector.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Do we want a Silicon Valley for healthcare?

Professor Tony Young is the National Clinical Director for Innovation at NHS England, co-founder of the UK’s £500M MedTech Campus, founder of the NHS Clinical Entrepreneur Programme and a consultant urological surgeon. Tony was awarded an OBE for services to clinical leadership in the 2019 New Year Honours List.

Tony has recently opened applications for the NHS Clinical Entrepreneur programme. Apply here: https://www.england.nhs.uk/aac/what-we-do/how-can-the-aac-help-me/clinical-entrepreneur-training-programme/

This is a really fun conversation — we cover Tony’s story, how and if the UK can make a Silicon Valley for healthcare and how to be charismatic.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

How do you achieve peak performance as a medical student, doctor or clinical academic?

Professor Neil Sebire works at the Great Ormond Street Hospital in London — the country's leading childrens' research hospital. He's published over 700 peer reviewed papers, has a h-index of 88 and 32,000+ citations. Here's everything he's learnt along the way.

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Find Professor Sebire:

LinkedIn: https://www.linkedin.com/in/neil-sebire-64780435/

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Cyndi Williams is the Co-founder and CEO of Quin; a digital therapeutic for type 1 diabetes. The app provides personalised, data-led support for insulin dosing decisions, based on physiological and behavioural factors.

Quin have raised £3.6 million pounds to date.

We talk about the process of building Quin, the joys and tribulations of fundraising, crowdfunding and the life of a CEO. I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro 

1:09 David Sinclair's New Startup  

11:25 ChatGPT for Drug Development 

28:32 Transhumanist Gene Editing to Sleep Less 

37:38 Banter/Audience Feedback  

Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). 

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

0:00 Intro 1:04 The genius business model of GetHarley 5:26 How important is marketing? 50% of revenue 14:57 Why aren't they doing cooler more innovative stuff? 22:38 What verticals would we expand GetHarley's biz model to 24:37 Vitamin vs painkiller 27:49 Why have investors put so much money into GetHarley? 31:00 Feedback and outro Links mentioned GetHarley, a skincare telehealth and consultation platform, raises $52M (TechCrunch): https://techcrunch.com/2023/06/06/get... Podcast Links YouTube:    / @bigpicturemedicine   Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

Hamish Grierson is the CEO and Co-founder of Thriva, a company which offers direct to consumer blood testing — with a broader mission of increasing healthspan — the number of years people spend in good health. For under £100 you can order a test kit, prick your finger at home and mail the blood sample back. This is then reviewed by a GP. In effect, they’re treating people like adults who can take charge of their own health and data.

Hamish came from the world of FinTech having headed International Payments and Remittance at Travelex, before co-founding Thriva in 2016. Thriva has raised $14.7 million dollars to date.

We talk about democratising access to healthcare testing and whether there should be limits on what tests we offer people, whether just giving people more data is the panacea in improving life and health span and how sometimes — outsiders are best placed to tackle some of the big problems in healthcare.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Healthcare leadership advice from Sir Bruce Keogh, Dr Eric Topol, Dr Susan Thomas, Dr Fiona Godlee, Dr Ben Maruthappu, Dr Claire Novorol, Will Gibbs, Prof Pearse Keane, Prof Neil Sebire, Melissa Morris and Will Gibbs.

All the greatest hits.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

After missing out on getting into Medical School, Ahmed studied Computer Science — later completing his PhD at Cambridge University. As a student, he launched his own health AI startup — which diagnosed rashes on intimate body parts.

This didn’t work out and he pivoted and launched a data AI company called Catalyst AI. This company was later acquired by Farfetch; the luxury online fashion retail platform to help optimise their fashion supply chains.

He now sits on the Prime Minister of Pakistan’s Science and Technology task force, on the Development Council of the Woolf Institute and is the Co-founder of a sustainable fashion enterprise.

We speak the about the unlikely overlaps between fashion and healthtech — no seriously there are lots of them, we speak about how to find your ultimate purpose and how when building relationships — the ultimate form of self-serving is being a giver.

I hope you enjoy.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io