a16z Podcast (Andreessen Horowitz)
Explore every episode of a16z Podcast
| Pub. Date | Title | Duration | |
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| 06 Dec 2024 | Fixing Education in America: What's Stopping Us? | 00:38:54 | |
Over half of Americans live in childcare deserts, while 90% of brain development happens before the age of five. All the while, education and childcare remain among the most resistant sectors to technological change. Billions of dollars have been spent, but outcomes continue to lag. Why? In this episode, we dive into the systemic issues—misaligned incentives, political resistance, and the lack of a shared vision around the purchase of an education. We also explore how technology and entrepreneurial innovation may be shifting the tide. You’ll hear from Anurupa Ganguly (Prisms), Chris Bennett (Wonderschool), Anna Edwards (Whiteboard Advisors), and a16z General Partner Jeff Jordan discuss the criticality of early childhood education, how public-private partnerships are required for scale, and how we can engage risk-averse decision-makers. Listen to learn how the next generation can reclaim the American dream.
Resources: Find Jeff on Twitter: https://x.com/jeff_jordan Find Chris on Twitter: https://x.com/8ennett Find Anna on LinkedIn: https://www.linkedin.com/in/annakimseyedwards/ Find Anurupa on Twitter: https://x.com/aganguly26
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 03 Feb 2023 | Healthspan, Lifespan, and the Biology of Aging | 00:36:45 | |
In this cross-over episode from Bio Eats World, Kristen Fortney, cofounder and CEO of BioAge, joins Vijay Pande, founding partner of a16z Bio + Health, and Olivia Webb, editorial lead, to discuss the biology of aging, how she started a company, and some fun things — like how long a hypothetical venture capitalist can expect to live.
Resources: Greg Egan, whose writing inspired Kristen, has a list of his books on his website
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 10 Jan 2023 | Expert AI as a Healthcare Superpower | 00:57:41 | |
In this episode, Marc Andreessen and Vijay Pande discuss expert AI and its role in healthcare, bio, and more.
Watch on Youtube: https://youtu.be/c7ScUDYSRYo Subscribe to Bio Eats World: https://podcasts.apple.com/us/podcast/bio-eats-world/id1529318900
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.
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| 23 Oct 2020 | Data Alone Is Not Enough: The Evolution of Data Architectures | 00:21:53 | |
Data, data, data – it’s long been a buzzword in the industry, whether big data, streaming data, data analytics, data science, even AI & machine learning — but data alone is not enough: it takes an entire system of tools and technology to extract value from data. | |||
| 18 Nov 2024 | The Longevity Imperative: Redefining the Way We Age | 00:40:30 | |
What if the biggest challenge of our time isn’t living longer, but living better? In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finance, career planning, and even our cultural perceptions of aging—need a fundamental overhaul. We’re joined by Dr. Andrew Scott, author of The Longevity Imperative, and Vijay Pande a16z’s Bio & Health general partner, to explore how a shift from “sick care” to “health care” could transform our lives. Together, we discuss the implications of longer lifespans, from the individual choices that can improve our healthspans to the economic and societal shifts required to sustain a healthier, more productive aging society. Join us as we reimagine the future of aging, where living to 100 can be more than survival—it can be a life well-lived.
Resources: Find Andrew on X: https://x.com/profandrewscott?lang=en Find Vijay on X: https://x.com/vijaypande Learn more about The Longevity Imperative: https://profandrewjscott.com/the-longevity-imperative/
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 24 Aug 2024 | Latin America: A Tech Powerhouse? | 00:33:07 | |
Latin America is emerging as a tech powerhouse, but it's not a one-size-fits-all market. In this episode, we explore why what works in Argentina won’t necessarily fly in Brazil or Mexico, and how companies are adapting to these unique regional dynamics. Join Dileep Thazhmon, Cofounder and CEO of Jeeves; Santiago Suarez, Cofounder and CEO of Addi; Gabriel Vasquez, a16z investment partner; and Angela Strange, a16z General Partner, as they discuss the future of fintech in LatAm and the unique approach required to succeed in this diverse market. Whether you're interested in the nuances of product development, the complexities of scaling across diverse markets, or the future of fintech in Latin America, this episode offers perspectives from industry leaders deeply invested in the region's tech ecosystem who believe the next big tech giants might just come from Latin America. Resources: Find Dileep on Twitter: https://x.com/thazhmon Find Santiago on Twitter: https://x.com/santiasua Find Gabriel on Twitter: https://x.com/gevs94 Find Angela on Twitter: https://x.com/astrange Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 30 Oct 2023 | Fintech Fuels Global Payments | 00:39:39 | |
Software crosses borders effortlessly. The globalization of money, however, is considerably more challenging. This is especially true for multinational businesses, which grapple with managing multiple accounts in diverse currencies, navigating costly foreign exchange rates, and unpredictable money transfers. As businesses increasingly embrace a global default, top fintech entrepreneurs are rising to the challenge, addressing cross-border infrastructure issues and offering comprehensive solutions. In this episode, a16z partners Angela Strange, Joe Schmidt, and Gabriel Vasquez discuss the challenges of cross-border payment infrastructures and what fintech entrepreneurs are doing to create a more integrated, financially inclusive world. Topics Covered: 00:00 - Software crosses borders easily; money does not. 03:02 - Why has global payments been a challenge for so long? 05:44 - How global payments and money currently moves 07:25 - The metrics used to measure a country's financial health 12:13 - The impact of regulation on financial services 16:23 - Can the same regulations be applied to any country? 21:29 - Why each country has its own fintech system 24:54 - Opportunities in global payments infrastructure 34:47 - Advice for founders navigating global fintech systems 36:58 - What does a truly global system enable? Read the Fintech Fuels Global Payments package: https://a16z.com/global-payments Watch ’Foreign Exchange 101: What Happens When You Send Money Abroad?’: https://youtu.be/eoXdyO9oGJc?feature=shared Find Angela on Twitter: https://twitter.com/astrange Find Joe Schmidt on Twitter: https://twitter.com/joeschmidtiv FInd Gabriel Vasquez on Twitter: https://twitter.com/GEVS94 Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 19 Sep 2023 | The Evolution of the Satellite Economy | 00:41:41 | |
The cost of launching payloads to orbit has dramatically dropped, igniting a space renaissance. In 2022, a record 186 rocket launches (41 more than the previous year!) underscores this shift. In Part 1 of our satellite economy mini-series, we sit down with John Gedmark, co-founder of Astranis, to reflect on today's innovations, who’s on the other side of the satellite market, the capabilities they’re looking for, competition, and their mission to provide internet access to 4 billion underserved people. Look out for Part 2, where we tackle the challenges of rapidly reusable rockets with Andy Lapsa from Stoke Space.
Resources: Learn more about Astranis: https://www.astranis.com Find John on Twitter: https://x.com/Gedmark?s=20
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 01 Mar 2023 | The Robot Lawyer Resistance | 00:48:28 | |
What happens when you don’t have the resources to fight for your rights? Whether it’s a major medical bill or a more minor parking ticket… even if you were in the right, is it easier to just… pay? Well, Joshua Browder's answer is Do Not Pay! He’s built a thriving company of the same name, that helps consumers “fight corporations, beat bureaucracy, and sue anyone at the press of a button.” Through the power of technology, DoNotPay has resolved over 2m cases successfully and in this interview we get to hear where Browder hopes to take the organization, including his first-hand account of his recent plan to bring the robot lawyer into the physical courtroom.
Topics Covered: 00:00 - Introduction 01:51 - DoNotPay’s origin 03:09 - Surprising laws 05:49 - General counsel for consumers 06:54 - The role of AI and technology 09:26 - Ensuring quality counsel 13:19 - Prioritizing features 14:43 - Corporate pushback 17:11 - Reshaping the legal system 20:28 - Entering the physical courtroom 24:50 - Cross border possibilities 26:14 - Looping humans into modeling 29:01 - Deflationary impacts 30:05 - Recent pushback 33:13 - Is AI already writing law? 35:15 - Why is law so complex? 37:54 - Entering the Supreme Court 38:38 - Lawyer support 39:47 - Looking forward 43:07 - Building horizontal vs vertical 45:28 - Does this law exist?
Resources: DoNotPay: https://donotpay.com/ Find Josh on Twitter: https://twitter.com/jbrowder1
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 14 Jan 2020 | Food, Drugs, and Tech—100 Years of Public Health | 00:44:55 | |
Covering everything from gene-editing your dog to tracking the next foodborne outbreak, this wide-ranging conversation between Principal Commissioner of the FDA Amy Abernethy and Vijay Pande, GP on the Bio Fund at a16z, discusses how the agency is evolving to keep pace with the scientific breakthroughs coming, while staying true to its core mission of assessing safety and effectiveness for consumers in the world of food and medicine. Highlights: What the FDA looks like today and the key steps of the FDA process to getting a drug/product to market [2:20] How to manage a culture when mitigating risk is a top priority while aiming to innovate for the future [5:22] Creative problem-solving in times of crisis, such as the Opioid crisis [9:58] Preparing for and preventing drug shortages at scale [13:30] How advances in bioengineering are transforming healthcare [16:00] How the FDA is thinking about n=1 therapies and its applications in the future [18:54] The future of healthcare privacy [26:10] The ways the clinical trial process are shifting [29:26] Innovations in Bioengineering as they relate to regulating food in the future [36:02] How the FDA handles foodborne illnesses and its plans to innovate food safety [39:12] Discussion about the next 100 years of the FDA [41:25] | |||
| 27 May 2024 | The GenAI 100: The Apps that Stick | 00:47:24 | |
Consumer AI is moving fast, so who's leading the charge? a16z Consumer Partners Olivia Moore and Bryan Kim discuss our GenAI 100 list and what it takes for an AI model to stand out and dominate the market. They discuss how these cutting-edge apps are connecting with their users and debate whether traditional strategies like paid acquisition and network effects are still effective. We're going beyond rankings to explore pivotal benchmarks like D7 retention and introduce metrics that define today's AI market. Note: This episode was recorded prior to OpenAI's Spring update. Catch our latest insights in the previous episode to stay ahead!
Resources: Link to the Gen AI 100: https://a16z.com/100-gen-ai-apps Find Bryan on Twitter: https://twitter.com/kirbyman01 Find Olivia on Twitter: https://x.com/omooretweets
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 30 Jan 2020 | All about the Coronavirus | 00:19:49 | |
This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV for 2019 novel coronavirus. Since it's an ongoing and fast-developing news cycle, we take a quick snapshot for where we are, what we know, and what we don't know, and discuss the vantage point of where tech comes in. Topics covered include:
Our a16z guest is Judy Savitskaya on the bio team, in conversation with Sonal Chokshi. Link sources or background readings for this episode:
Other background readings / pieces mentioned in this episode:
image: CDC | |||
| 09 May 2023 | When Two Giants Intersect: Healthcare Meets Fintech | 00:49:58 | |
Most people don’t need a reminder of the state of healthcare in America. But it’s not just the consumer that’s hurting. Medical debt is increasing, billions are lost in unpaid claims, hospitals are in the red, service prices can range up to 30x…. In this episode, a16z GPs Julie You and David Haber explain where the healthcare system breaks down and how the three party system — between payors, providers, and consumers — can be rethought through the lens of Fintech. Learn more about Healthcare x Fintech here: https://a16z.com/healthcare-meets-fintech/ Topics Covered:
Resources:
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 01 Apr 2020 | The Hustlers's Guide to Suing the Man | 00:28:44 | |
This is the next cycle (Q1 2020) of Hustlin' Tech, a podcast series (from the a16z Podcast) about technology platforms that create opportunities for people. Recorded right before the coronavirus pandemic, these next 3 episodes touch on many things that are top of mind right now: from the profession of nursing and taking care of the elderly and the professionalization of caregivers; to fighting bureaucracy to get money back (and to now get help delaying utility bills and rent payments that are eligible for an extension or waiver of late fees due to the coronavirus crisis). Episode #6, “The Hustler’s Guide to Suing the Man” features:
...both interviewed by Ben Horowitz and Shaka Senghor. You can find the first cycle of this series (Q4 2019) -- including more about the what and the why -- here. | |||
| 24 Apr 2023 | Beyond Avatars: How AI is Reshaping Online Identity | 00:39:42 | |
In a recent episode, we delved into the first wave of technology that was used to create digital influencers like 'Lil Miquela back in 2016. Fast forward to today, we're presented with a whole new set of tools that enable almost anyone to build their own digital influencer. In this episode, Sinead Bovell and Danny Postma discuss the transformative impact of artificial intelligence on the world of modeling, online creation, and self-representation. From the rise of AI-generated photos to the democratization of creativity, they discuss the potential of AI in shaping the future of digital expression. Topics Covered:
Resources: Find Danny Postma on Twitter: https://twitter.com/dannypostmaa Headshot Pro, ProfilePicture.Ai plus all of Danny’s projects at: https://www.postcrafts.com/ Find Sinéad Bovell on Instagram: https://www.instagram.com/sineadbovell/?hl=en
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 02 Jun 2022 | Crypto, an Oral Essay | 00:39:33 | |
In this special “innovation overview” episode from April 2021, the a16z crypto team and other experts take you from the ground up of crypto and web3 — from the basics, to more recent developments, and beyond – through the lens of an oral essay with brief segments on what crypto is, how it really works, and where it’s going. We chose this particular archive episode this week in honor of a new show that just launched: web3 with a16z. Hosted by Sonal Choksi, the previous showrunner of the a16z podcast network and longtime host of this show, and featuring the team at a16z crypto as well as leading scientists and makers in the space, this show is about the next generation of the internet, how builders and users now have the ability to "own" (web3) pieces of the internet, unlocking a new wave of creativity and entrepreneurship. The first two episodes are out this week, so check out and subscribe to “web3 with a16z” wherever you get your podcasts. | |||
| 02 Sep 2024 | Governing democracy, the internet, and boardrooms | 01:35:38 | |
with @NoahRFeldman, @ahall_research, @rhhackett Welcome to web3 with a16z. I'm Robert Hackett and today we have a special episode about governance in many forms — from nation states to corporate boards to internet services and beyond. Our special guests are Noah Feldman, constitutional law scholar at Harvard who also architected the Meta oversight board (among many other things); he is also the author of several books. And our other special guest is Andy Hall, professor of political science at Stanford who is an advisor of a16z crypto research — and who also co-authored several papers and posts about web3 as a laboratory for designing and testing new political systems, including new work we'll link to in the shownotes. Our hallway style conversation covers technologies and approaches to governance, from constitutions to crypto/ blockchains and DAOs. As such we also discuss content moderation and community standards; best practices for citizens assemblies; courts vs. legislatures; and much more where governance comes up. Throughout, we reference the history and evolution of democracy — from Ancient Greece to the present day — as well as examples of governance from big companies like Meta, to startups like Anthropic. Resources for references in this episode:
A selection of recent posts and papers by Andrew Hall:
As a reminder: none of the following should be taken as tax, business, legal, or investment advice. See a16zcrypto.com/disclosures for more important information, including a link to a list of our investments. | |||
| 02 May 2021 | Man, Mosquito, Malaria Vaccine | 00:36:20 | |
Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the news that came out a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in preprint with The Lancet, the resulting buzz and phrases quoted included everything from “unprecedented”, “groundbreaking work”, and “very exciting” to “high expectations”, “highly effective”, and “a hugely significant extra weapon”... A "weapon" in the war against malaria that is -- a disease that is estimated to cause over 400,000 deaths each year globally, and predominantly in children under the age of five. So in this special 2x explainer episode of 16 Minutes (also running on the a16z Podcast), we -- Rajeev Venkayya of Takeda Pharmaceuticals, a16z bio general partner Jorge Conde, and Sonal Chokshi -- dig into what's hype/ what's real about this news, beyond the headlines and beyond the buzz. What does the data tell us, what does the current study phase mean, and what's left to get to widespread, real-world use? How does this candidate vaccine (R21 from Jenner Institute/ Oxford University) compare to the other malaria vaccine (RTS,S from GlaxoSmithKline)? How do, and don't, advances in and around COVID vaccines play here? And why has it been so hard to develop vaccines for this particular disease? Because we also cover (as is the premise of the show) where we are on the long arc of innovation... and this is an innovation story that's been nearly a century in the making. | |||
| 06 May 2020 | Undruggable Drugs | 00:28:39 | |
In this episode of the a16z Podcast, we take a deep dive into the world of drug development—specifically "undruggable drugs": a category of protein, protein family or even piece of RNA that’s so difficult to target that many researchers don’t even want to touch it. Jay Bradner, President of the Novartis Institute for BioMedical Research, shares with a16z General Partners Jorge Conde and Vijay Pande, and a16z's Hanne Tidnam, all the new tools, technologies and breakthroughs which are causing the science of therapeutics to explode in some of these areas where it's been incredibly difficult (even impossible) in the past. From molecular glues to cell and gene therapies, Bradner shares the behind-the-scenes science stories of what it really takes to make a new drug that shatters the category of an "undruggable" target. | |||
| 29 Jan 2024 | The What, Who, and When with IPOs | 00:34:26 | |
In 2022 and 2023, US IPOs hit decade lows after the record high of 2021. Now, in 2024, will the IPO window reopen? In this episode, we revisit a conversation with Jeff Jordan, former CEO of OpenTable, and J.D. Moriarty, the former Head Managing Director and Head of Equity Capital Markets at Bank of America Merrill Lynch. Joined by Sonal Choksi, the pair takes you behind the scenes to unravel the complexities surrounding IPOs, including pricing, allocations, and the elusive "pop." They also discuss OpenTable’s IPO, which occurred immediately following the worst financial crisis since the Great Depression, and weigh in on the question: Can you time an IPO in an unpredictable year?
Resources: Find Jeff on Twitter: https://twitter.com/jeff_jordan Find J.D on LinkedIn: https://www.linkedin.com/in/jdmoriarty Find Sonal on Twitter: https://twitter.com/smc90
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 15 May 2020 | Growth in Turbulent Times | 00:36:26 | |
In normal times, every company operates against some hypothetical growth model—a data-driven framework that describes how your product grows and how you acquire new users. These, of course, are not normal times. In the fallout from the pandemic, most founders and CEOs are in the process of completely revamping their growth models from the bottom up amid new and unpredictable consumer behavior. This episode explores how to think about growth in turbulent times, according to two growth experts: a16z general partner Andrew Chen, who previously led the growth team at Uber, and Brian Balfour, formerly the VP of Growth at HubSpot, now the founder and CEO of Reforge, a masterclass in growth strategies (in conversation with host Lauren Murrow). The discussion spans four sections: first, how to reassess your existing growth model, particularly when, as Brian says, the data is "completely messed"; next, we drill down into strategy and tactics for surviving the current crisis and talk about how founders can pursue growth even in the midst of widespread uncertainty and cutbacks. Third, we look ahead to discuss scenario planning and how leaders can forge a path forward. Finally, we zoom out and assess the big picture: how various categories of company may be impacted long-term, how this crisis compares to 2008 (and what that means for early-stage founders), and the industries and business models that are now prime for growth.
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| 21 Dec 2020 | The Machine That Made the Vaccine: Company, Platform, Innovation | 00:40:03 | |
In this special episode of Bio Eats World -- which aired right after the FDA authorized Moderna's mRNA vaccine for emergency use -- Moderna CEO Stephane Bancel tells the story of not just the vaccine’s development, but the machine that made the vaccine: the platform, the technology, and the moves behind the vaccine’s development. How does this new technology that uses mRNA work; why is this such a fundamental shift in the world of drug development; and where will this technology go next?
https://a16z.com/2020/12/18/moderna-covid-vaccine-mrna-technology/ | |||
| 11 Nov 2021 | Play-to-Earn Gaming and How Work is Evolving in Web3 | 00:23:06 | |
In today's episode we’re talking about an emerging model of gaming called play to earn, in which players can make actual money based on how much time and effort they put into a game. Play to earn is also part of broader trends — the changing relationship between players and platforms, new incentives for participants in blockchain-based networks, and the new internet era that is coming to be known as a web3.
The top play-to-earn game is called Axie Infinity, operated by a Vietnam-based company called Sky Mavis. Players of the game acquire unique digital pets called Axies, and battle other teams of Axies. These NFT Axies can be created and sold using the game’s in-game currency, SLP, which can be traded for traditional currency.
Think of it as Pokemon on the blockchain, with a social network built-in, and an actual economy, and even companies built around the game that help players onboard and loan them money to get started playing. The game has made more than $3 billion in total sales since launching in March 2018, with much of its early growth in the Philippines.
(As a reminder, none of the following should be taken as investment advice, please see a16z.com/disclosures for more important information.)
Our guests today are Jeff Zirlin, the cofounder of Sky Mavis; Gabby Dizon, the cofounder of Yield Guild Games, a play to earn gaming guild that gives players the resources to start playing; and a16z crypto general partner Arianna Simpson.
They talk to a16z's Zoran Basich about the tech trends that enabled the emergence of play to earn, why and where it caught on first, and the role of community, as well as the challenges, which include onboarding and scalability, and the economic sustainability of this model. The panel also discusses what the play-to-earn movement say about the future of work.
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| 05 Aug 2024 | Building the World's Most Trusted Driver | 00:38:36 | |
Waymo's autonomous vehicles have driven over 20 million miles on public roads and billions more in simulation. In this episode, a16z General Partner David George sits down with Dmitri Dolgov, CTO at Waymo, to discuss the development of self-driving technology. Dmitri provides technical insights into the evolution of hardware and software, the impact of generative AI, and the safety standards that guide Waymo's innovations. This footage is from AI Revolution, an event that a16z recently hosted in San Francisco. Watch the full event here: a16z.com/dmitri-dolgov-waymo-ai
Resources: Find Dmitri on Twitter: https://x.com/dmitri_dolgov Find David George on Twitter: https://x.com/DavidGeorge83 Learn more about Waymo: https://waymo.com/
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 22 Jan 2025 | RIP to RPA: How AI Makes Operations Work | 00:17:06 | |
Intelligent automation is transforming industries by tackling messy, unstructured workflows that traditional Robotic Process Automation (RPA) couldn’t handle. In this episode, a16z partner Kimberly Tan discusses the shift from rigid RPA systems to AI-powered agents and why this evolution unlocks massive opportunities in legacy markets. Drawing on her article "RIP to RPA: The Rise of Intelligent Automation," Kimberly shares real-world examples of companies revolutionizing referral management, and highlights how startups can build impactful solutions in this space. Resources: Find Kimberly on X: https://x.com/kimberlywtan Read Kimberly’s article: https://a16z.com/rip-to-rpa-the-rise-of-intelligent-automation/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 15 Oct 2021 | Crypto Security and the New Web3 Mindsets for Users | 00:31:09 | |
Today’s episode is all about crypto security — that is, the new mindsets and the new strategies for storing crypto assets safely while also allowing holders control and access.
As a reminder, none of the following should be taken as investment advice, please see a16z.com/disclosures for more important information.
We’ve covered security trends more broadly a ton in our content, which you can find at a16z.com/security, as well as crypto-related trends including NFTs, and the creator and ownership economies; you can find all of that at a16z.com/nfts
But as more people enter crypto lately — thanks to the boom in NFTs, decentralized finance, and much more — we share specific best practices and options for securing crypto as well as discussing how it all fits this next evolution of the internet: web3.
Our expert today is a16z crypto data scientist Eddy Lazzarin, who joins host Zoran Basich to cover practical approaches ranging from passwords to crypto wallets and what users can do; the evolution of crypto briefly; and the big picture mindset shifts involved here as well.
We quickly begin with the practical shift crypto security represents compared to how people interact with traditional financial institutions, and then we go into the big picture trends in security when it comes to abstraction and usability.
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| 25 Sep 2023 | AI Revolution: Top Lessons from OpenAI, Anthropic, CharacterAI, & More | 00:38:01 | |
The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying attention to. You’ll hear about the economics of AI, broad vs specialized models, the importance of UX, and whether we can expect scaling laws to continue. This footage is from an exclusive event, AI Revolution, that a16z ran in San Francisco recently. If you’d like to access all the talks in full, visit a16z.com/airevolution.
Topics Covered 00:00 - AI Revolution 01:42 - The economics of AI 06:55 - The third epoch of compute 13:52 - Recognizing scaling laws 17:42 - Can scaling laws continue? 22:34 - Potential bottlenecks 25:58 - Personalization vs generality 29:43 - The importance of UX 31:55 - The future of multi-modality
Resources: Catch the all the talks at https://a16z.com/airevolution
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 02 Dec 2024 | Prediction Markets and Beyond | 01:49:49 | |
This episode was originally published on our sister podcast, web3 with a16z. If you’re excited about the next generation of the internet, check out the show: https://link.chtbl.com/hrr_h-XC We've heard a lot about the premise and the promise of prediction markets for a long time, but they finally hit the main stage with the most recent election. So what worked (and didn't) this time? Are they really better than pollsters, is polling dead? So in this conversation, we tease apart the hype from the reality of prediction markets, from the recent election to market foundations... going more deeply into the how, why, and where these markets work. We also discuss the design challenges and opportunities (including implications for builders throughout). And we also cover other information aggregation mechanisms -- from peer prediction to others -- given that prediction markets are part of a broader category of information-elicitation and information-aggregation mechanisms. Our special expert guests are Alex Taborrok, professor of economics at George Mason University and Chair in Economics at the Mercatus Center; and Scott Duke Kominers, research partner at a16z crypto, and professor at Harvard Business School -- both in conversation with Sonal Chokshi. As a reminder: None of the following should be taken as business, investment, legal, or tax advice; please see a16z.com/disclosures for more important information.
Resources:
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 18 Mar 2021 | The Third Vaccine, and Vaccine Choice | 00:12:48 | |
https://a16z.com/2021/03/15/16-minutes-58-the-johnson-johnson-vaccine-and-covid-efficacy-rates/ | |||
| 06 Jan 2023 | Creators, Creativity, and Technology with Bob Iger | 01:20:46 | |
with @robertiger @cdixon @smc90 A wide-ranging conversation with Bob Iger on the interplay between technology, content, and distribution; as well as Bob’s journey -- and that of various creators! -- especially as the industry evolved from TV and cable to the advent of the internet/ web 1.0 to 2.0 to briefly touching on web3 and other emerging technologies. As well as topics top of mind for all company and community builders: from build vs. buy and the innovator's dilemma, to managing creativity, decentralization, remote work, and much more.
Subscribe to web3 with a16z: https://podcasts.apple.com/us/podcast/web3-with-a16z-crypto/id1622312549
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 17 Apr 2024 | Game On: Marc Andreessen & Andrew Chen Talk Creative Computers | 00:40:39 | |
The gaming industry stands as a pioneer of cutting-edge technologies, ushering in innovations like GPUs, virtual and augmented reality, physics engines, and immersive multiplayer experiences. In this episode, a16z cofounder Marc Andreessen and Andrew Chen, General Partner at a16z Games, dig into why a16z was compelled to establish a dedicated games fund. They explore the origins of tech pessimism, effective engagement with government in tech, its significance for the gaming community, the ongoing AI revolution, and even what Marc himself would build today if he didn't have his hands full. Recorded as part of a16z's extensive games fund accelerator, SPEEDRUN, this session offers valuable insights for founders and innovators at the intersection of games and technology. If you're passionate about shaping the future of gaming, consider applying for SPEEDRUN 3.0 at a16z.com/speedrun3.
Resources: Find Marc on Twitter: https://twitter.com/pmarca Find Andrew on Twitter: https://twitter.com/andrewchen Submit your SPEEDRUN 3.0 application: https://a16z.com/speedrun-la-2024
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 04 Dec 2023 | The Quest for AGI: Q*, Self-Play, and Synthetic Data | 00:26:38 | |
One topic at the center of the AI universe this week is a potential breakthrough called Q*. Little has been revealed about this OpenAI project, other than its likely relationship to solving certain grade-school mathematical problems. Amid much speculation, we decided to bring in our new general partner, Anjney Midha – focused on all things AI – to sift through the sea of noise. Today, we discuss the key frontier research areas that AI labs are exploring on their path toward generalizable intelligence, from self-play, to model-free reinforcement learning to synthetic data. Anjney also shares his insights on which approach he expects to be most influential in the next wave of LLMs and why math problems are even a suitable testing ground for this kind of research.
Topics Covered: 02:03 - What is Q*? 06:21 - Applying model-free reinforcement learning to complex spaces 13:17 - The role of self-play 19:04 - Synthetic data’s big unlock 24:44 - What does this unlock for society?
Resources: Follow Anjney on Twitter: https://twitter.com/AnjneyMidha
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 06 Mar 2020 | Innovation Through Software Development and IT | 00:45:05 | |
One of the recurring themes we talk about a lot on the a16z Podcast is how software changes organizations, and vice versa... More broadly: it’s really about how companies of all kinds innovate with the org structures and tools that they have. But we've come a long way from the question of "does IT matter" to answering the question of what org structures, processes, architectures, and roles DO matter when it comes to companies -- of all sizes -- innovating through software and more. So in this episode (a re-run of a popular episode from a couple years ago), two of the authors of the book Accelerate: The Science of Lean Software and DevOps, by Nicole Forsgren, Jez Humble, and Jean Kim join Sonal Chokshi to share best practices and large-scale findings about high performing companies (including those who may not even think they’re tech companies). Nicole was co-founder and CEO of Dora, which was acquired by Google in December 2018; she will soon be joining GitHub as VP of Research & Strategy. Jez was CTO at DORA; is currently in Developer Relations at Google Cloud; and is the co-author of the books The DevOps Handbook, Lean Enterprise, and Continuous Delivery.
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| 19 Apr 2023 | Insights from the Frontlines of Consumer Tech | 00:35:20 | |
There is arguably nothing that impacts our daily lives more than consumer technology. This technology can drive our ability to change careers, build an audience, or feel understood. And in this episode, listeners get a sneak peek into our new consumer series, Field Notes, where a16z’s very own Connie Chan speaks with the builders, creators, and investors behind the technology that shapes our daily lives. If you like these segments, you can find the full episodes at a16z.com/fieldnotes. Topics Covered:
Resources: Find the full series: https://a16z.com/fieldnotes Find Connie on Twitter: https://twitter.com/conniechan Deb's Part 1: https://www.youtube.com/watch?v=Is2pm06MNt8 Deb's Part 2: https://www.youtube.com/watch?v=osJp6S66u2U Chris's episode: https://www.youtube.com/watch?v=Zux1wVirUjs
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 08 Jul 2024 | Marc Andreessen on Building Netscape & the Birth of the Browser | 01:42:50 | |
"The Ben & Marc Show," featuring a16z co-founders Marc Andreessen and Ben Horowitz. In this special episode, Marc and Ben dive deep into the REAL story behind the creation of Netscape—a web browser co-created by Marc that revolutionized the internet and changed the world. As Ben notes at the top, until today, this story has never been fully told either in its entirety or accurately. In this one-on-one conversation, Marc and Ben discuss Marc's early life and how it shaped his journey into technology, the pivotal moments at the University of Illinois that led to the development of Mosaic (a renegade browser that Marc developed as an undergrad), and the fierce competition and legal battles that ensued as Netscape rose to prominence. Ben and Marc also reflect on the broader implications of Netscape's success, the importance of an open internet, and the lessons learned that still resonate in today's tech landscape (especially with AI). That and much more. Enjoy! Watch the FULL Episode on YouTune: https://youtu.be/8aTjA_bGZO4
Resources: Marc on X: https://twitter.com/pmarca Marc’s Substack: https://pmarca.substack.com/ Ben on X: https://twitter.com/bhorowitz Book mentioned on this episode: - “Expert Political Judgment” by Philip E. Tetlock https://bit.ly/45KzP6M TV Series mentioned on this episode: - “The Mandalorian” (Disney+) https://bit.ly/3W0Zyoq
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 12 Jun 2020 | The Return of Home-based Healthcare | 00:26:51 | |
The way we deliver healthcare has changed enormously over the last century, shifting from house calls by doctors to your own to institutionalized settings like hospitals and clinics. But now that trend has started to shift again, as some of the care we get in the hospitals and clinics has been "unbundled" back towards home settings for chronically ill patients or seniors. And now, of course, the impact of COVID-19 has created a huge sudden demand for home-based care, as all of us try to figure out how to manage certain healthcare needs at home. So, is home-based healthcare better? And what do we truly need to deliver the best care to patients, in their own homes? What do we gain and lose in different care delivery settings, and what shifts of mindset and new logistical processes do we need now, to best accomplish unbundling healthcare into the home? In this conversation, Vijay Kedar, CEO and cofounder of Tomorrow Health, a tech platform that delivers the products and services needed for home-based care; Sachin Jain, physician, previous CEO of Caremore and Aspire Health; part of the founding team at CMMI, the Centers of Medicare and Medicaid Innovation, now incoming CEO of The Scan Group and Healthplan; and a16z General Partner Julie Yoo join a16z's Hanne Tidnam in conversation to talk about where we are today and where we are going in home-based healthcare. | |||
| 09 Aug 2024 | The Olympics of Talent: France's Tech Boom | 00:37:02 | |
Once criticized for lacking ambition, French founders are now aiming to create the world’s largest companies. With a thriving ecosystem attracting talent from across Europe and the US, France is becoming a major player on the global stage. In this episode, we cover the unique advantages of building startups in France. Roxanne Varza, Director of Station F; Antoine Martin, co-founder of Amo and Zenly; and Brian Kim, a16z consumer partner, discuss the key factors driving this transformation, including infrastructure, community, and government support. Discover how international talent, a supportive community, and robust governmental backing are propelling France’s startup scene. This episode is filled with insights into why France is now an exciting place to build a startup. Resources: Find Roxanne on Twitter: https://x.com/roxannevarza Find Antoine on Twitter: https://x.com/an21m Find Bryan on Twitter: https://x.com/kirbyman01 Learn more about Station F: https://stationf.co/ Learn more about Amo: https://get.amo.co/en Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 10 Apr 2024 | Inside the Department of Defense and its Vision for the Future | 00:30:19 | |
From air-defining radar and electronic systems that helped the Allies win World War II, the origins of Silicon Valley are deeply rooted in government and defense. In today's episode, we get the chance to revisit that relationship with the United States Deputy Secretary of Defense, Kathleen Hicks. Deputy Secretary Hicks has spent decades of her career focused on defense policy and in her keynote address from a16z's second annual American Dynamism Summit in Washington, D.C., you'll get an inside look into the priorities of the DoD and how it views its past, present, and future. In the second half of the episode, you’ll hear highlights from Deputy Secretary Hicks' fireside chat with Wall Street Journal’s National Security Editor, Sharon Weinberger, where they dive into the numerous issues facing our country today, from Ukraine to the use of AI on the battlefield.
Resources: Find Deputy Secretary Hicks on Twitter: https://twitter.com/depsecdef Find Sharon on Twitter: https://twitter.com/weinbergersa To learn more about the American Dynamism Summit: www.a16z.com/ad-summit Visit the full playlist of American Dynamism Summit videos on YouTube: https://bit.ly/3IqWn1W
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 02 Jan 2020 | Why We Should Be Optimistic About the Future | 00:44:30 | |
Many skeptics thought the internet would never reach mass adoption, but today it’s shaping global culture, is integral to our lives -- and it's just the beginning. In this conversation from our 2019 innovation summit, Kevin Kelly (Founding Executive Editor, WIRED magazine) and Marc Andreessen sit down to discuss the evolution of technology, key trends, and why they're the most optimistic people in the room. *** The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. | |||
| 06 Jul 2022 | All About Synthetic Biology | 00:36:21 | |
Over the last 20 years, the idea of “designing biology” has gone from science fiction to just science, as the field of synthetic biology has exploded, with applications from therapeutics to manufacturing and more. In this episode from January 2019, one of the pioneers in the field, professor James J. Collins of MIT, joins a16z general partner on the Bio + Health fund, Vijay Pande, and editorial partner Hanne Winarsky, to discuss the origins of synthetic biology or "synbio", to what "engineering and designing" biology really looks like in action and the disciplinary differences between how biologists and engineers see the world. | |||
| 22 Nov 2022 | Neal Stephenson on The Future of the Metaverse | 01:18:22 | |
When Neal Stephenson coined “the metaverse” three decades ago, his book Snow Crash was found on the shelves of “science fiction”. While the book remains in that category, many of its concepts are now found in reality… Fast forward to 2022, where numerous companies are now building toward their version of the metaverse, including Neal himself – working on Lamina1 – a blockchain company oriented toward creators. While the present metaverses don’t perfectly mimic that from Stephenson’s early imagination, we get the unique opportunity to discuss the various design decisions that he’s making, but also the intersection between the metaverse and gaming, the involvement that AR/VR might play, the evolving role of IP, how artificial intelligence fits in, what he’s building and why, and where he gets all of his ideas from. Timestamps: 0:00 - Introduction 1:20 - Tech's highest impact position 4:35 - What is the metaverse? 6:46 - Interoperability 8:52 - Incentive alignment 13:06 - Immersion requirements 16:30 - VR engineering challenges 20:09 - Skeuomorphism 24:17 - Commercial VR/AR applications 27:26 - AI and gaming 30:51 - The value chain 38:13 - Right of refusal 42:05 - Good and bad tech 46:05 - Fighting “free” 49:16 - Building Lamina1 58:07 - Neal’s design designs 1:03:40 - Inspiration for Snow Crash 1:09:16 - Looking ahead from 2022 1:11:59 - Science fiction writing 1:13:46 - Carbon removal
Resources: Neal’s Twitter: https://twitter.com/nealstephenson Lamina1’s website: https://www.lamina1.com/
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app:https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 17 Jul 2024 | Transitioning From Gymnast to Investor with Aly Raisman | 00:21:39 | |
Former gymnast and current investor Aly Raisman joins general partner Julie Yoo and investment partner Daisy Wolf of a16z Bio + Health. In this episode, Aly Raisman shares her quest for healthier living—physically, mentally, and financially—on her journey from gymnast to a business investor. Having transitioned from an intensely structured routine, Aly emphasizes the need for more open conversations about mental health and financial literacy. She speaks passionately about the gap in women’s health solutions and hopes to inspire entrepreneurs to create impactful businesses. Aly’s experiences as a patient, survivor, and global figure adds a unique dimension to her perspective as an investor. This candid conversation with Aly and Julie Yoo sheds light on Aly’s passion for more education within the investment space, offering invaluable insights for entrepreneurs, particularly in biotech and healthcare.
Resources: Find Aly on Twitter: https://x.com/aly_raisman Find Julie on Twitter: https://x.com/julesyoo Find Daisy on Twitter: https://x.com/daisydwolf
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 07 Sep 2024 | Grand Challenges in Healthcare AI | 00:37:40 | |
Vijay Pande, founding general partner, and Julie Yoo, general partner at a16z Bio + Health, come together to discuss the grand challenges facing healthcare AI today. The talk through the implications of AI integration in healthcare workflows, AI as a potential catalyst for value-based care, and the opportunity for innovation in clinical trials. They also talk about the AI startup they each wish would walk through the door.
Resources: Find Vijay on Twitter: https://x.com/vijaypande FInd Julie on Twitter: https://x.com/julesyoo Listen to more episode from Raising Health: https://a16z.com/podcasts/raising-health/
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 03 Sep 2022 | How to Find Product-Market-Sales Fit | 00:51:46 | |
In this episode from February 2019, Jyoti Bansal, founding CEO of AppDynamics and co-founder of Unusual Ventures, joins a16z general partner Peter Levine, a16z partner Sateesh Talluri, and host Sonal Choksi to discuss how product and sales evolve together for enterprise go-to-market, including key milestones for both product development and marketing, frameworks for how to think about pre- to post-product market fit, the role of additional levers like services or pricing, and more. For the show transcript, you can go here. | |||
| 13 Jul 2022 | Crisis Communications 101 | 00:34:20 | |
In this hallway-style conversation with a16z's Margit Wennmachers, longtime operating partner for Marketing, and Kim Milosevich, CMO for a16z crypto, open up the black box of crisis communications with Sonal Choksi and explore the process and mindsets before, during, and after a crisis. They discuss common FAQs like: What constitutes a crisis? Can someone inside a company "call it" early and prevent a crisis from becoming a bigger deal? How do you respond when there's a lag or too much time between acknowledging the issue and finding out all the facts? Who should be in the (war) room ? Should you share the off-the-record background story with reporters? How do you know when a crisis begins and ends -- or that you're ready for a "comeback" story? We explore all this and more. | |||
| 30 Jun 2020 | Preventing Pandemics with Genomic Epidemiology | 00:34:56 | |
The COVID-19 pandemic has increased the visibility of scientists and the scientific process to the broader public; suddenly, scientists working on virology and infectious disease dynamics have seen their public profiles rapidly expand. One such scientist is the special guest in this episode, Trevor Bedford, Associate Professor at the Fred Hutchinson Cancer Research Center. An expert in genomic epidemiology, he and his collaborators built Nextstrain, which shares real-time, interactive data visualizations to track the spread of viruses through populations. a16z bio deal team partner Judy Savitskaya and Lauren Richardson chat with Trevor about how genomic epidemiology can inform public health decisions; viral mutation and spillover from animals into humans; what can be done now to prevent the next big pandemic; and the shift in scientific communication to pre-prints and open science. | |||
| 13 Nov 2020 | The Great Data Debate | 00:26:28 | |
Lakes v. warehouses, analytics v. AI/ML, SQL v. everything else... As the technical capabilities of data lakes and data warehouses converge, are the separate tools and teams that run AI/ML and analytics converging as well? In this podcast, originally recorded as part of Fivetran's Modern Data Stack conference, five leaders in data infrastructure debate that question: a16z general partner and pioneer of software defined networking Martin Casado, former CEO of Snowflake Bob Muglia; Michelle Ufford, founder and CEO of Noteable; Tristan Handy, founder of Fishtown Analytics and leader of the open source project dbt; and Fivetran founder George Fraser. The conversation covers the future of data lakes, the new use cases for the modern data stack, data mesh and whether decentralization of teams and tools is the future, and how low we actually need to go with latency. And while the topic of debate is the modern data stack, the themes and differing perspectives strike at the heart of an even bigger: how does technology evolve in complex enterprise environments? | |||
| 30 Nov 2022 | The Economics of Carbon Removal with Nan Ransohoff | 00:58:49 | |
What happens when there’s demand for a solution that doesn’t quite exist yet? Today, we bring on Nan Ransohoff to talk about this exact problem as it relates to carbon removal, and how Frontier — the initiative out of Stripe that she is leading – is using a nearly $1B advanced market commitment fund to try to jumpstart this market. If you don’t know what that means, don’t worry – we’ve got you covered. Throughout the episode, we discuss the multivariate carbon equation and why emission reductions are not enough, the difference between offsets and permanent removal, who’s paying for tons today, what solutions already exist and how Frontier is vetting them, moving down the cost curve, where policy fits in, and ultimately what success might look like in this nascent industry. This is part 1 of our 3-part series on carbon removal. Look out next week for part 2 and part 3, where we dive into a growing marketplace for carbon and showcase several carbon removal solutions.
Resources: Frontier’s website: https://frontierclimate.com/ Nan’s Twitter: https://twitter.com/nanransohoff Nan’s article: https://nanransohoff.com/A-mental-model-for-combating-climate-change-846be1769d374fa1b5b855407c93da66
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 27 Nov 2019 | How We Podcast | 00:47:44 | |
"Hi everyone, welcome to the a16z Podcast..." ... and welcome to our 500th episode, where, for the first time, we reveal behind-the-scenes details and the backstory of how we built this show, and the broader editorial operation. [You can also listen to episode 499, with head of marketing Margit Wennmachers, on building the a16z brand, here.] We've talked a lot about the podcasting industry, and even done podcasts about podcasting, so for this special episode, editor-in-chief and showrunner Sonal Chokshi reveals the how, what, and why in conversation with a16z general partner (and guest-host for this special episode) podcasting fan Connie Chan. We also answer some frequently asked questions that we often get (and recently got via Twitter), such as:
...and much more. In fact, much of the conversation goes beyond the a16z Podcast and towards Sonal's broader principles of 'editorial content marketing', which hopefully helps those thinking about their own content operations and podcasts, too. Including where podcasting may be going. Finally, we share some unexpected moments, and lessons learned along the way; our positions on "tics", swear-words, and talking too fast; failed experiments, and new directions. But most importantly, we share some of the people behind the scenes who help make the a16z Podcast what it was, is, and can be... with thanks most of all to *you*, our wonderful fans! | |||
| 16 Apr 2025 | The Dual-Use Founder: Vets Now Building For America | 00:37:51 | |
In today’s world, the battlefield extends far beyond war zones—it’s embedded in our tech stacks, supply chains, and airspace security systems. So who better to solve these modern challenges than those who’ve served on the front lines? Recorded live at the third annual American Dynamism Summit in Washington D.C., this episode features a16z’s Matt Shortal—a veteran himself—moderating a conversation with three founders who transitioned from military service to building cutting-edge defense startups:
The panel covers their journeys from service to startups, how their time in uniform shaped what they chose to build, and whether veterans should go straight into entrepreneurship—or stop first at places like Palantir or Anduril. They also discuss how Ukraine changed the game, how dual-use tech is shifting the innovation landscape, and how to instill trust and culture in mission-driven companies. The big question: how do we win the next war—the asymmetric, fast-moving, tech-enabled kind—and build the industrial base we need to do it?
Resources: See more from The American Dynamism Summit 2025: www. a16z.com/american-dynamism-summit Find John of LinkedIn: https://www.linkedin.com/in/john-doyle-48633227/ Find David on LinkedIn: https://www.linkedin.com/in/davidtuttle1/ Find Grant on LinkedIn: https://www.linkedin.com/in/grantjordansd/ Find Matt on LinkedIn: https://www.linkedin.com/in/matthew-shortal/
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 21 Jul 2022 | From Research to Startup, There and Back Again | 00:55:50 | |
In this episode from December 2018, Hennessy, currently the chairman of Alphabet as well as Turing Award-winning computer scientist, joins a16z co-founder Marc Andreessen, a16z general partner Martin Casado, and host Sonal Choksi for a wide-ranging conversation about moving from academia to startups, the history of Silicon Valley, the “Stanford model”, how to build enduring organizations, and more. Hennessy also co-founded startups, including one based on pioneering microprocessor architecture used in 99% of devices today (for which he and his collaborator won the prestigious Turing Award)... so what did it take to go from research/idea to industry/implementation? And how has the overall relationship and "divide" between academia and industry shifted, especially as the tech industry itself has changed? Finally, in his book, Leading Matters, Hennessy shares some of the leadership principles he's learned, offering nuanced takes on topics like humility (needs ambition), empathy (without contravening fairness and reason), and others. What does it take to build not just tech, but a successful organization? | |||
| 05 Nov 2020 | How to Moderate Talks, Panels, Meetings, More (Virtual and Beyond!) | 01:02:50 | |
How to moderate good, productive discussions and navigate tricky conversations is top of mind -- whether doing a panel, conducting a live event, presenting a talk (or hosting a podcast), managing (and even just participating in!) a meeting. Especially in a world where remote and virtual work is increasingly become the norm for many knowledge workers, one in which we're increasingly communicating through little "Hollywood Squares, Brady Bunch"-like boxes. So how to translate physical and nonverbal presence in such virtual environments, or voice-only modes? How to manage unruly discussions? Do parasocial vs. social interactions change things? And beyond these broader contexts, how do the things inside us -- whether agendas, tics, anxiety -- manifest outwardly, and can we better control them? In this episode of the a16z Podcast, Matt Abrahams -- lecturer at Stanford’s Graduate School of Business (where he also has a podcast, "Think Fast Talk Smart"); principal and co-founder of Bold Echo (a company that helps people with presentation and communication skills); and author of Speaking Up Without Freaking Out -- shares frameworks and best practices, in conversation with Sonal Chokshi. The discussion offers many concrete tips for moderation and communication for anyone, across all kinds of mediums and modes.
image: Paul Hudson / Flickr | |||
| 12 Jul 2023 | Curing the Trust Problem with Mark Cuban | 00:41:04 | |
Today’s episode is with Mark Cuban, founder of multiple businesses, owner of the Dallas Mavericks, one of the sharks on Shark Tank, and cofounder of the Mark Cuban Cost Plus Drug Company. He is joined by Vijay Pande, founding partner of a16z Bio + Health. Together, they talk market forces in healthcare, the importance of trust to patients, and Mark’s ideas to tackle the Gordian knot that is American healthcare.
Listen to our last two episodes on Healthcare x Fintech:
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 29 Jun 2022 | Mining the Data for Cobalt | 00:33:24 | |
In this episode from July 2019, Kurt House, CEO and co-founder of Kobold Metals, John Thompson, professor of earth and geosciences at Cornell; and Connie Chan, a16z general partner for consumer, talk with editorial partner Hanne Winarsky about the way technology is transforming how we find cobalt, and the mining industry as a whole, as well as the science behind why cobalt is so critical for batteries, the data and knowledge behind mining today vs the past, and more. | |||
| 19 May 2024 | A Big Week in AI: GPT-4o & Gemini Find Their Voice | 00:23:54 | |
This was a big week in the world of AI, with both OpenAI and Google dropping significant updates. So big that we decided to break things down in a new format with our Consumer partners Bryan Kim and Justine Moore. We discuss the multi-modal companions that have found their voice, but also why not all audio is the same, and why several nuances like speed and personality really matter.
Resources: OpenAI’s Spring announcement: https://openai.com/index/hello-gpt-4o/ Google I/O announcements: https://blog.google/technology/ai/google-io-2024-100-announcements/
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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| 25 May 2023 | The Rise of the Exponential Organization | 01:06:39 | |
Many companies today are grappling with a few things: an economic downturn, potential layoffs and restructuring, and trying to keep up with the latest tech trends… all while still maintaining a growth trajectory. In this episode, you’ll learn which companies are uniquely designed to weather this storm and what attributes these exponential organizations have. We’re joined by the co-authors of Exponential Organzations, Peter Diamandids and Salim Ismail, both also well-known for their involvement in XPrize and Singularity University, among many other companies. Topics Covered:
Resources: Attend the Exponential Organization workshop on June 6: https://www.diamandis.com/exo Learn more about Peter: https://www.diamandis.com/about Learn more about Salim: https://salimismail.com/
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 21 Apr 2020 | Introducing Read Alouds | 00:00:33 | |
We wanted to let you know about a special new series of posts occasionally read out loud from us (you can learn more about the why and why now in episode #500 on how we podcast); we may release these in a separate feed in future, for now, the first episode is next in this feed. Thank you for listening! You can also check out our other shows and series: | |||
| 26 May 2022 | Stories of Startup Survival Mode | 00:33:00 | |
In this episode from February 2017, a16z co-founder Ben Horowitz and Jason Rosenthal, former Lytro CEO (now Vice President, Subscription Services, at Google) share stories and lessons learned from doing whatever they could to help their companies survive in hard times, including making and living through major pivots, selling new products before they were ready, figuring out financing with market and industry headwinds against them, and more. From their days together at LoudCloud to Jason’s experience at Lytro, and beyond, a common theme emerges: a CEO’s job is lonely in these moments and the hardest thing about a big pivot or change might be in finding the courage to make the decision in the first place. | |||
| 09 Nov 2022 | Why Technology Still Matters with Marc Andreessen | 01:25:03 | |
With much coverage of technology lined with pessimism, the a16z Podcast returns to highlight the bright side of technology, alongside the founders building it. But before featuring the solutions in progress, we wanted to explore why building the future is still so important. And who better to traverse this ground than a16z’s own cofounder Marc Andreessen, who has built and invested in the future time and time again, especially when it wasn't the obvious thing to do. Together with Marc, this episode explores technology through the lens of history – including the three stages of human psychology as we encounter new technologies, how that process often manifests in regulation, when to change your mind, the Cambrian explosion of opportunity coming from distributed work, the importance of founder-led companies, and perhaps most importantly, we examine why there's still much reason for optimism. Timestamps: 00:00 - Welcome back! 02:19 - The importance of tech today 05:25 - Historical negativity toward technology 9:40 - The invention of the bicycle 13:16 - Innovation vs status in society 20:45 - Automobile moral panic and red flag laws 24:52 - Balaji’s arc on social networking 27:44 - Surfacing signal from noise 34:06 - The role of timing in innovation 37:39 - Today’s major unlocks 44:59 - Remote work and society reshuffling 49:49 - Changing your mind 54:06 - Retaining a lens of optimism 1:04:25 - What Marc’s excited about 1:08:41 - Bourgeois vs managerial capitalism 1:17:32 - Reform vs starting anew
Resources: Marc on Twitter: https://twitter.com/pmarca Pessimist’s Archive: https://pessimistsarchive.org/
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.com/podcasts Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 19 Dec 2019 | Are ISAs the Solution to Student Debt? | 00:27:51 | |
A bold proposal: You go to college for free, then pay back the school after graduation—but only if you get a job in your field of study and make a high enough salary to afford it. It's called an income share agreement, and Austen Allred, the CEO and cofounder of Lambda School, thinks it's the future of education. Student debt currently stands at more than 1.5 trillion dollars, which makes it the second-highest consumer debt category behind mortgage debt. The crisis has saddled much of a generation, with far reaching effects. Income share agreements, or ISAs, have been put forth as an alternative to the current system. Put simply, an ISA is an agreement between a school and a student for the student to pay a defined percentage of income to the school, for a particular period of time, up to a certain cap. It's a seemingly simple conceit with complex design considerations, and it's spurring debate across media and politics. In this episode, Lambda School CEO Austen Allred, a16z general partner D'Arcy Coolican, and a16z editorial partner Lauren Murrow delve into the greater implications ISAs may have for education and the economy. The discussion covers both the promise and the challenges of ISAs—why they've been relatively slow to gain traction, why they've failed in the past, and why some in the political sphere are still skeptical. | |||
| 03 Jan 2025 | Crypto Trends for 2025: Stablecoins, App Stores, UX, and More | 00:34:54 | |
with @sambroner @meigga @darenmatsuoka @jneu_net @chrislyons and @rhhackett @smc90 Welcome to our special end-of-year episodes -- which also look ahead to 2025 -- covering our annual Big Ideas lists, where various a16z crypto team members share what they are personally excited about. (You can see the firmwide list, also including all the trends of the crypto team, here.) This episode is part 1 of 2 -- but you don't have to listen to them in any particular order -- covering the trends and themes of:
Covering each of these -- and coming from the investing, go-to-market, data science, research, and media teams are: Sam Broner, Maggie Hsu, Daren Matsuoka, Joachim Neu, and Chris Lyons; in conversation with hosts Sonal Chokshi and Robert Hackett. (Stay tuned until the end for some of our meta-commentary.) These are just 5 of the 14 trends we shared; you can check out the full list at a16zcrypto.com/bigideas. Also be sure to check out part 2, which covers all the trends at the intersection of crypto and AI. As a reminder, none of the content is investment, business, legal, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments. | |||
| 28 Sep 2023 | AI Revolution: Disruption, Alignment, and Opportunity | 00:31:32 | |
The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying attention to. You’ll hear discussion around the real-world impact of this revolution, on industries ranging from gaming to design, and the considerations around alignment along the way. This footage is from an exclusive event, AI Revolution, that a16z ran in San Francisco recently. If you’d like to access all the talks in full, visit a16z.com/airevolution.
Topics Covered: 00:00 - AI Revolution 02:39 - Putting technology in users’ hands 08:21 - AI alignment and safety 21:44 - Future opportunities
Resources: Catch the all the talks at https://a16z.com/airevolution
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 15 May 2023 | Embedding AI: The Questions Every CEO is Asking | 00:36:31 | |
2022 was a breakout year for AI. While machine learning had already been integrated into applications for millions of users, for many, these tools still felt like their first real-world encounter with AI. As AI continues to revolutionize industries, CEOs are discussing how to integrate this new superpower. They are also considering important questions around data privacy, competition, cost, accuracy, and speed. In today's episode, we talk with Cresta, Hex, and Sourcegraph, three companies at the forefront of integrating AI into their existing products. From navigating data privacy concerns to optimizing accuracy and managing costs, these leaders are navigating the complexities of this new superpower. Topics Covered:
Resources: Find Barry McCardel on Twitter https://twitter.com/barrald Find Beyang Liu on Twitter: https://twitter.com/beyang Find Zayd Enam on Twitter: https://twitter.com/zaydenam Recent AI episodes:
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see
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| 24 Aug 2023 | Wartime vs Peacetime: Ben Horowitz on Leadership | 00:35:19 | |
In this exclusive conversation from a16z’s Bio and Health BUILD Summit, founding partner Ben Horowitz sits down with general partner Jorge Conde. They discuss everything from the inspiration behind Ben’s book The Hard Thing About Hard Things, how the open Internet was secured, the difference between wartime and peacetime CEOs, scaling culture, and understanding how bio & healthcare differs from other forms of technology.
Topics Covered: 00:00 - Introduction 02:09 - What are the most important lessons for a CEO? 08:45 - Surprising leaders in history 11:41 - Wartime CEO vs the peacetime CEO 14:54 - Cultures role 20:59 - Communication and scaling 25:39 - Culture as a moat 27:46 - The interplay between startups and incumbents 30:22 - Advice for founders on navigating AI
Resources:
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 25 Mar 2020 | The Delivery-Optimized Future of Food | 00:18:40 | |
The spike in online ordering and food delivery—a trend that's particularly relevant now—is evidence of how tech is fundamentally changing how and what we eat. Is this the end of the traditional restaurant experience as we know it? In this conversation between Virtual Kitchen Co. CEO Ken Chong, Snackpass CEO Kevin Tan, a16z general parter Andrew Chen, and host Lauren Murrow, we discuss what's driving this transformation, the infusion of data into the restaurant industry, how take-out and delivery is becoming surprisingly social, and the specter of the "kitchenless home." Virtual Kitchen Co. is a network of delivery-only kitchens that partners with restaurants to expand their reach without opening additional brick-and-mortar locations. Snackpass is a food-ordering app currently on college campuses in which customers can order ahead at restaurants and skip the line. In this discussion, both CEOs explain what their business models could mean for the future of dining and cooking. This episode was recorded on-site at the a16z Summit in November 2019. | |||
| 26 Jun 2023 | The Road to Autonomous Vehicles: Are We There Yet? | 00:56:00 | |
Self-driving cars have been on the horizon for quite some time. But, they might actually be here. We got to ride around in one all over San Francisco with Waymo’s Chief Product Officer, Saswat Panigrahi. We discussed so much, including the five levels of autonomy, the infamous LIDAR vs video debate, regulation, UX, and the role of AI in fine-tuning these models. But most importantly, if autonomy is here… now what?! Topics Covered:
Resources: Check out Waymo: https://waymo.com/ Check out Waymo's Youtube channel: https://www.youtube.com/@Waymo Find Saswat on Twitter: https://twitter.com/saswat101 Check out a16z's 8-part series on the autonomous vehicle ecosystem: https://a16z.com/2018/02/03/autonomy-ecosystem-frank-chen-summit/ Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 18 May 2022 | Innovating While Scaling: Lessons from Amazon | 01:04:22 | |
In this episode from February 2021, early Amazon execs Colin Bryar and Bill Carr -- in conversation with a16z's Sonal Chokshi -- go beyond the well-known artifacts of Amazon innovation, like the memo and the press release, and share the leadership principles, decision making practices, and operational processes that helped Amazon continue to innovate, invent new products and learn from its mistakes, as it scaled. It’s all based on their book, Working Backwards: Insights, Stories, and Secrets from Inside Amazon, drawing from the 27 years combined experience of being in the room where it happened at Amazon. | |||
| 15 Oct 2019 | Of Emojis and Innovation | 00:38:40 | |
This rerun podcast (first recorded in 2015, now being rerun as one of our evergreen classics/ favorites) -- is ALL about emoji. But it's really about how innovation really comes about: through the tension between open standards vs. closed/ proprietary systems; the politics of time and place; and the economics of creativity, from making to funding. So yes, this podcast is all about emoji. But it's also about where emoji fits in the taxonomy of social communication, and why that matters -- from making emotions machine-readable to being able to add "limbic" visual expression to our world of text. And if emoji is a language, why can't we translate it; why so ambiguous?? How do emojis work, both technically underneath the hood... and in the (committee) Room Where It Happens? Joining this episode are former VP of Data at Kickstarter Fred Benenson (and the man behind 'Emoji Dick'); and former New York Times reporter and current Unicode Emoji subcommittee vice-chair, Jennifer 8. Lee (and one of the women behind the dumpling emoji) -- in conversation with Sonal Chokshi. image: Yiying Lu (@yiyinglu) | |||
| 16 Jun 2020 | Real Estate in a Pandemic: Homeowners and Buyers (Part 1) | 00:24:54 | |
This episode is the first in a two-part series that examines the pandemic’s impact on real estate. Part 1 focuses on prospective home buyers, sellers, and existing homeowners. Part 2 (streaming on 6/17) addresses renters and landlords. How has social distancing shaken up the market to buy? What’s the ripple effect of eviction freezes and a record number of homes in forbearance? And how can tech streamline the inefficient process of renting, buying, and selling a home? Led by host Lauren Murrow, the conversation features a16z general partner Alex Rampell, who has invested in a number of real estate companies; Malloy Evans, Fannie Mae’s senior vice president and single-family chief credit officer; and Tushar Garg, CEO of Flyhomes, a company that helps buyers in competitive markets by purchasing their desired house in cash, then selling it to that buyer at the same price. The discussion starts with the impact on home prices and volume, as well as the rumored exodus from densely populated cities. Then we shift to focus on existing homeowners. Finally, we talk about ways tech can improve the system, from hard tech to fintech. For more a16z content on real estate and proptech, visit a16z.com/realestate. | |||
| 19 Jan 2023 | The Human Behind the Genius | 00:22:30 | |
In this special episode, we share never heard before footage from Steve Wozniak alongside his cofounder and best man, Alex Fielding. Listeners get an inside look into what drove Woz to building a computer, but also how Steve’s zest for life was applied beyond computers – from the rare opportunity to play Tetris on the side of a building or throw a concert across borders.
Full Privateer episode: https://a16z.simplecast.com/episodes/new-the-data-highway-above-with-privateers-steve-wozniak-alex-fielding-and-dr-moriba-jah Full Privateer episode on Youtube: https://youtu.be/ZZbrwxOs0y4
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 26 Jan 2022 | M&A, Before and After: What Founders Need to Know | 00:25:47 | |
Welcome to the a16z podcast. Today we’re talking about the mindsets and frameworks founders should know about when navigating the mergers and acquisitions or M&A process, both before and after – including how to think about the pricing dynamics, factors that go into the decision-making process, and what to expect from the integration once the deal is done. A16z editorial partner Zoran Basich recently talked to two a16z experts here to give us their big-picture view of the most important things to know – for founders seeking to acquire companies and how they might think about it, or those considering selling a company, or just those deciding to merge with an acquirer. Blake Kim is a partner on our Enterprise Network team and a former investment banker who works with companies on strategic partnerships; he also recently co-wrote a post on Future outlining all the different exit options and considerations for companies. And general partner Martin Casado discusses common M&A issues and shares his experiences both as observer and participant – including the challenges of integration, which he saw from the inside with Nicira, which he cofounded and was acquired by VMware for $1.26 billion in 2012, and where he remained for years to lead its networking and security business unit. As a reminder, none of the following should be taken as investment advice. Please see a16z.com/disclosures for more important information. They start the discussion by outlining the frameworks for understanding M&A dynamics, including the “kingmaking dynamic” and the difference between “selling your company” and “getting acquired.” | |||
| 07 Nov 2022 | The a16z Podcast Returns | 00:02:49 | |
The long-standing (and chart-topping) a16z Podcast returns to cover the most important topics within the world of technology. Brought to you by the minds at Andreessen Horowitz (a16z) and hosted by Steph Smith, each episode goes beyond headlines, giving listeners insider access to the edge of innovation. Subscribe to be the first to receive upcoming episodes featuring industry leaders like Steve Wozniak, Marc Andreessen, Balaji Srinivasan, and Neal Stephenson, and covering a range of topics, from AI to space to the metaverse to genomics, and beyond.
Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.com/podcasts Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 17 Jun 2020 | Real Estate in a Pandemic: Renters and Landlords (Part 2) | 00:31:20 | |
This episode is the second in a two-part series that examines the pandemic’s impact on real estate. Part 1 focused on prospective home buyers, sellers, and existing homeowners. This episode, Part 2, addresses renters and landlords. The conversation with host Lauren Murrow features a16z general partner Connie Chan, whose experience as a landlord herself has fueled her interest in residential real estate and technology; Richard Green, the director of USC's Lusk Center for Real Estate, and Adena Hefets, the CEO of Divvy Homes, a company that allows people to build up equity while renting a home, with the option to eventually buy it. We begin with the pressures on renters—and the uncertainty around federal relief measures—as well as the cascading effects on mom-and-pop landlords. Then we turn to the outlook for prices and volume in the rental market, particularly in large cities like New York and San Francisco. Finally, we discuss the opportunity for tech to solve outdated and inefficient processes for both renters and landlords. For more a16z content on real estate and proptech, visit a16z.com/realestate. | |||
| 04 Dec 2020 | On Fear and Leadership: Product to Sales CTOs & CEOs | 00:42:47 | |
There's a few ontologies for describing the phases leaders -- and their startups -- go through, whether it's product-sales-etc. or pioneer to settler. In any case, as companies evolve, so must the leaders -- but can the same person transition across all these phases? When and when not; what are the qualities, criteria, and tradeoffs to be made? In this episode of the a16z Podcast, originally recorded as an internal hallway-style chat (pre pandemic!) a16z general partner Martin Casado, who co-founded but decided to remain CTO of Nicira -- and previously shared his own journey, lessons learned, and advice for founders about bringing in an external CEO and the question of "to CTO or not to CTO" -- and Armon Dadgar, co-founder (with Mitchell Hashimoto) and CTO of HashiCorp, chat with Sonal Chokshi about both managing their past psychology through these common questions and decisions. They also share their strategies on managing the specific tactics behind it all: Everything from the "dating" process of finding an external CEO to figuring out swim lanes; handling debates and decisions; who presents, who sells. And while the conversation is a brief glimpse into their longer personal journeys, there's lessons in it for startups and leaders of all kinds on the art of hiring and sales, managing credit and conflict, and more... | |||
| 11 May 2022 | When Gross Margins Matter | 00:36:17 | |
Gross margins–which are essentially a company’s revenue from products and services minus the costs to deliver those products and services to customers–are one of the most important financial metrics for any startup and growing business. And yet, figuring out what goes into the “cost” for delivering products and services is not as simple as it may sound, particularly for high-growth software businesses that might use emerging business models or be leveraging new technology. In this episode from June 2020, a16z general partners Martin Casado, David George, and Sarah Wang talk all things gross margins, from early to late stage. Why do gross margins matter? When do they matter during a company’s growth? And how do you use them to plan for the future? The conversation ranges from the nuances of and strategy for calculating margins with things like cloud costs, freemium users, or implementation costs, to the impact margins can have on valuations. | |||
| 04 Aug 2022 | The Art and Science of Moderating Discussions | 01:03:32 | |
Whether it’s moderating a live panel discussion, managing your (virtual) All Hands meeting, or even guiding a cross-functional team to a decision in an important meeting, mastering the art of helping a group communicate is a critical skill for many of us. In this episode from November 2020, expert communications and presentations coach Matt Abrahams, who is also a lecturer at Stanford’s Graduate School of Business, sits down with Sonal Choksi to share frameworks, strategies and many concrete tips for how anyone can become a better moderator and facilitator. They cover everything from how to approach prep work (like, can you be too prepared?) and how to handle disruptions on the fly to the subtle differences between in-person and virtual events, the ways our own ticks can manifest before an audience, and more. | |||
| 05 Sep 2023 | Salary Transparency: Clarity or Chaos? | 00:40:05 | |
With recent landmark legislation being passed around salary transparency, many companies are playing catch up as they interpret and implement changes. In this episode, members of the a16z People Operations team, Shannon Schiltz and Brandon Cherry explore how companies can best prepare themselves to not just survive, but thrive in this new environment.
Topics Covered: 00:00 - Salary transparency legislation 01:52 - The culture around pay transparency 03:39 - What is the legislation? 07:01 - How are companies reacting? 11:03 - Structuring a compensation philosophy 12:30 - Pay ranges 15:35 - Exceptions to the pay range 18:17 - Leveling staff 22:30 - Ranges and roles and company growth 28:24 - Location based pay 30:05 - What should employees look for when applying for work? 32:19 - Job postings 35:05 - Reviewing compensation ranges 35:42 - At what stage do you hire help?
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 28 Aug 2024 | It’s Time to Build in Healthcare | 00:41:04 | |
Half of prescribed medications are never taken, and 88% of Americans are metabolically unhealthy. Despite spending 20% of our GDP on healthcare—twice that of any other developed nation—our outcomes still lag behind. In this episode, we explore why technologists must step into the healthcare ring. Solving medicine isn’t enough; we need to make healthcare a consumer-focused industry. a16z’s Vijay Pandey and Daisy Wolf discuss the rise of tech founders in healthcare, the potential of AI to transform patient care, and how this shift could lead to the next trillion-dollar company. Can tech truly disrupt this complex, regulated industry?
Resources: Read the article ‘It’s Time to Build in Healthcare’: https://a16z.com/hey-tech-its-time-to-build-in-healthcare/ Find Vijay on Twitter: https://x.com/vijaypande Find Daisy on Twitter: https://x.com/daisydwolf
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 20 May 2020 | Podcasting and the Future of Audio | 01:06:51 | |
This podcast (first recorded in 2019, now being rerun) -- is a podcast about podcasting: But it's really all about audio. A lot's changed... and a lot hasn't. How do we define "podcasts"; how does the feeds ecosystem currently work; what content and entertainment experiments might change how people not just consume, but create, in the medium? Not to mention monetize, discover, etc... Nick Quah, writer and publisher of Hot Pod (also at Vulture) joins a16z general partner Connie Chan -- and editor in chief (and showrunner of the a16z Podcast) Sonal Chokshi -- to talk about all this and more in this hallway-style jam.
The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.) Past performance is not indicative of future results. Any charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see https://a16z.com/disclosures for additional important information. | |||
| 07 Apr 2020 | The Story of Schizophrenia | 00:37:38 | |
Descriptions of the mental illness we today call schizophrenia are as old as humankind itself. And more than likely, we are are all familiar with this disease in some way, as it touches 1% of us—millions of lives—and of course, their families. In this episode, we dive into the remarkable story of one such American family, the Galvins: Mimi, Don, and their 12 children, 6 of whom were afflicted with schizophrenia. In his new book, Hidden Valley Road: Inside the Mind of an American Family, Robert Kolker follows the family from the 1950s to today, through, he writes, "the eras of institutionalization and shock therapy, the debates between psycho-therapy versus medication, the needle-in-a-haystack search for genetic markers for the disease, and the profound disagreements about the cause and origin of the illness itself." Because of that, this is really more than just a portrait of one family; it’s a portrait of how we have struggled over the last decades to understand this mysterious and devastating mental illness: the biology of it, the drivers, the behaviors and pathology, the genomics, and of course the search for treatments that might help, from lobotomies to ECT to thorazine. Also joining Robert Kolker and a16z's Hanne Tidnam in this conversation is Stefan McDonough, Executive Director of Genetics at Pfizer World R&D, one of the genetic researchers who worked closely with the Galvins. The conversation follows the key moments where our understanding of this disease began to shift, especially with new technologies and the advent of the Human Genome Project—and finally where we are today, and where our next big break might come from. | |||
| 14 Aug 2023 | Classroom 2050: Unleashing AI, XR, Gaming | 00:40:14 | |
With students learning in more places and different ways than we have ever seen, the pace of change in education is dizzying. Can this progress narrow learning gaps exacerbated by COVID-19 or will it fuel divides? How can we make the most of this once-in-a-generation opportunity? Join our panelists from Khan Academy, PrismsVR, and Minecraft Education as we discuss the classroom of the future, and how important technologies including AI, XR, and gaming should play a role in it.
Topics Covered: 00:00 – The classroom of 2023 04:30 – Data on the current classroom 05:40– Developing the next gen of STEM talent 08:00 – AI in the classroom 13:10 – The role of gaming in the classroom 16:00 – Misconceptions of technology in classroom 17:51 – The ways teachers and students use AI 21:15 - The future role of a teacher 24:25 – Personalization and ownership in education 27:11 – Getting hardware into the classroom 29:54 - Misconceptions of teacher’s abilities and appetite for tech 31:25 – Why implement these changes now? 36:05 – Call to action for the classroom of 2050
Resources:
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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| 13 Jan 2021 | Developers as Creatives | 00:33:18 | |
The rise of developers -- as buyers, as influencers, as a creative class -- is a direct result of "software eating the world", and of key shifts in IT from on-prem to cloud & SaaS to the API economy, where application programming interfaces are essentially building blocks for innovation. Developers therefore not only play an outsized role in high-performing tech companies -- but managing and motivating them is actually critical in ALL companies, since every company is a tech company (whether they know it or not). As every industry turns digital, and a company's interface to their customers IS software, "asking" one's developer is the key to solving business problems and to thriving not just surviving, argues Jeff Lawson, CEO and co-founder of cloud communications platform-as-a-service company Twilio, in his new book, Ask Your Developer: How to Harness the Power of Software Developers and Win in the 21st Century. So in this episode of the a16z Podcast in conversation with Sonal Chokshi and David Ulevitch (who previously argued "the developer's way" is the future of work), Lawson shares hard-earned lessons learned, mindsets, strategies, and tactics -- from "build vs. buy" to "build vs. die", to the art and science of small teams ("mitosis") -- for leaders and companies of all sizes. But what does it mean to truly treat developers as creatives within an organization? What does it mean to be "developer first"? And how does this affect customers, product, go-to-market? All this and more in this episode. | |||
| 24 Nov 2022 | Ryan Petersen on Rearchitecting the Supply Chain | 00:18:15 | |
In today’s episode, we have a special treat. Flexport’s co-CEO and Founder, Ryan Petersen, chats with a16z Growth Editor Das Rush. They start with the question of why Ryan has chosen – of all the problem spaces to work on – improving the resiliency of the supply chain. They cover just how complex the supply chain is in the era of ecommerce, evolving customer expectations, and ultimately how we can rearchitect our supply chain to meet them. Given the holiday shopping coming up, you won’t want to miss this. Timestamps: 0:00 - Introduction 1:24 - Why the supply chain? 3:31 - Land and expand 6:38 - The most interesting company? 9:24 - The impact of ecommerce 14:05 - Building resiliency
Resources: Ryan’s Twitter: https://twitter.com/typesfast Flexport’s website: https://www.flexport.com/
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||
| 22 Jul 2020 | Taking the Pulse on Medical Device Security | 00:23:16 | |
Many don’t realize we even need to think about the possibility of security hacks when it comes to things like pacemakers, insulin pumps, and more. But when bits and bytes meet flesh and blood, security becomes literally a life or death concern. So what are the issues and risks we need to be aware of in exposing security vulnerabilities in connected biomedical devices? This conversation—with Beau Woods, Cyber Safety Innovation Fellow with the Atlantic Council, part of the I Am The Cavalry grassroots security initiative, Founder/CEO of Stratigos Security; Andy Coravos, co-founder and CEO of Elektra Labs, advisor to the Biohacking Village at DEF CON (both of whom were formerly EIRs at the FDA); and a16z's Hanne Tidnam covers how we should begin to think about addressing these security issues in the biomedical device space. What are the frameworks that should guide our conversations, and how and when (and which!) stakeholders should be incentivized to address these challenges? How did the FDA begin to think about security as part of the safety of all medical devices, including software as a medical device, and how we should think about understanding, monitoring, and updating the security of these devices—from philosophical statements to on-the-ground practical fixes and updates? | |||
| 23 Jun 2023 | Network Effects, Moats, & the Business of web3 | 01:18:24 | |
with @skominers @smc90 In this deep dive and tour through key business concepts, from theory to practice, we cover the topics of strategy, competitive advantage, network effects, moats, and more -- covering both both basic foundations, as well as the tricky nuances in a new world of open source, including web3. In the first half of this discussion, we cover foundational business concepts and questions -- such as the nature of competition, and how it *really* changes in web3; as well as how network effects really work -- and then, in the second half (in case you want to skip ahead), we cover mindsets and general guidance for builders… Our expert guest -- in conversation with editor in chief and host Sonal Chokshi -- is a16z crypto research partner Scott Duke Kominers, who is also a professor at Harvard Business School; a faculty affiliate in Harvard’s Department of Economics; and advises several companies on marketplace development, incentive design, and more; as well as advises, and is directly involved, in several NFT communities. Scott also teaches on these topics -- both at Harvard and also recently at our Crypto Startup School -- so be sure to subscribe to our playlist for those talks on the a16z crypto YouTube channel to get the latest updates as we release more videos from the 2023 cohort. Listen to web3 with a16z: https://web3-with-a16z.simplecast.com/ related links // see also:
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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| 17 Apr 2021 | Crypto, an Oral Essay | 00:38:34 | |
This is a special episode of the a16z podcast — it's an audio history, told through the voices of the a16z crypto team, about what crypto is, how it really works, and why it matters. This "innovation overview" is meant as a resource, and it features hallway-style conversations with the a16z team as well as outside experts. In brief segments, we’ll take you from the ground up — from the basics, to the most current developments, and beyond that to a look at what we might see in the future. Here are the topics and voices you'll hear: The Beginning
Expansion
Right Now
The Future
For more crypto resources, please see our Crypto Startup School page, our documentary about the program, and our NFT Canon. ### The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. In addition, this content may include third-party advertisements; a16z has not reviewed such advertisements and does not endorse any advertising content contained therein. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. | |||
| 09 Aug 2020 | Journal Club: Slaying the Sleeper Cells of Aging with CAR T | 00:18:00 | |
CAR T therapy is a groundbreaking medicine that uses engineered T cells to attack cancer. But CAR T cells (that is, chimeric antigen receptor T cells) can be programmed to recognize a huge range of target proteins and cell types. So what other types of cells should we train CAR Ts to recognize and destroy to improve human health? On this episode of the a16z Journal Club, a16z General Partner Jorge Conde, bio deal team partner Andy Tran, and Lauren Richardson discuss new research published in Nature in which the authors engineer CAR T cells to recognize and kill senescent cells. Cellular senescence is a process where cells stop dividing (sort of go to sleep), and in many cases this can be protective, like its role in tumor suppression, but if too many cells become senescent of if they are not removed, they can trigger inflammation and cause disease, like in atherosclerosis and type 2 diabetes. Critically, senescent cells build up as we age and contribute to a whole host of age-related conditions. In this episode we cover how the authors created these senescence killing (aka senolytic) CAR T cells, the diseases that could be treated with senolytic CAR Ts, the hurdles to getting them into the clinic, and how they could potentially be used to treat aging and possibly improve longevity. “Senolytic CAR T cells reverse senescence-associated pathologies” in Nature (June 2020) by Corina Amor, Judith Feucht, Josef Leibold, Yu-Jui Ho, Changyu Zhu, Direna Alonso-Curbelo, Jorge Mansilla-Soto, Jacob A. Boyer, Xiang Li, Theodoros Giavridis, Amanda Kulick, Shauna Houlihan, Ellinor Peerschke, Scott L. Friedman, Vladimir Ponomarev, Alessandra Piersigilli, Michel Sadelain & Scott W. Lowe a16z bio Journal Club (part of the a16z Podcast), curates and covers recent advances from the scientific literature -- what papers we’re reading, and why they matter from our perspective at the intersection of biology & technology. You can find all these episodes at a16z.com/journalclub. | |||
| 02 Jun 2023 | The Future of Cheese | 00:30:24 | |
Today’s episode is with Magi Richani, founder and CEO of Nobell Foods. She is joined by a16z Bio + Health general partner Vijay Pande. Together, they talk about the details of engineering plants to create the future of food, why Nobell started with soybeans to produce their cheese, and her dream of finding a cheese pizza—with Nobell cheese—at any pizza shop across the country. | |||
| 23 Sep 2019 | 16 Minutes on the News #9: All the Recent Phone Hacks | 00:19:50 | |
This is episode #9 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they’re in the news; why they matter from our vantage point in tech -- and share our experts’ views on the trends involved. This week we do a short but deep dive to tease apart the FUD from the facts on all the phone hacks of late (also, arguably, one of the worst years on record for certain device manufacturers) -- given the following news:
Finally, how should we think about phone authentication overall when it comes to security, and what can we do to secure ourselves? Our a16z experts -- general partner Martin Casado and former chief security officer/ operating partner for security Joel de la Garza -- share their thoughts on all this and more with host Sonal Chokshi, in this episode of 16 Minutes. --- The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at a16z.com/investments. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see a16z.com/disclosures for additional important information. | |||
| 11 Sep 2020 | The Question of Education | 00:58:54 | |
Monopoly, oligopoly, cartel. All three of those words can describe the (not so) modern education system today, given the cost structures, economics, and accreditation capture -- in everything from who can and can't start a new university (when was the last time a significant change happened there anyway?!) to where government funding really goes to the student loan and debt crisis. Yet degrees do matter, just not for the reasons we think. So what are the tradeoffs -- when it comes to the "right" school, making money, and assessing skills objectively -- between what's been called "hard" (B.S.) and "soft" (B.A.) degrees? What's the best book on career advice, and what advice does Marc Andreessen -- who went to a public university, worked on a revolutionary project there, and started a company right after -- have for students (and others contemplating change in their careers)... and especially for those considering dropping out, delaying, or skipping college altogether? Andreessen shares his thoughts on the purpose, past and present of education (briefly touching on the impact of the pandemic as well) with Dylan Field, CEO of Figma, which is free for students and educators. The Q&A was recorded in August 2020 and originally appeared as a video in their "Back to School?" interview series; it was actually inspired by the question of taking a gap year and questions about whether or not to go back to school this year that came up in their Virtual Campus community of students from across the world.
image: Lyndsy Rommel / Flickr | |||
| 28 Oct 2022 | Is a Fun, Therapeutic Game Possible? | 00:33:57 | |
In this special episode from a16z’s Bio Eats World podcast, general partners Vijay Pande and Jon Lai join bio editorial lead Olivia Webb to discuss the intersection of games and health, including: what constitutes a game, the “healthy dessert” problem, and the challenge of building a game that’s both fun and therapeutic. You can subscribe to Bio Eats World wherever you get your podcasts. | |||
| 03 Dec 2019 | Of Container Ships, Supply Chains, and Retail | 00:33:58 | |
This podcast rerun -- first recorded over two and a half years ago, now being rerun as one of our evergreen classics on the tails of the world's largest designated shopping days (Black Friday, Singles Day in China, Prime Day online, and so on) -- is ALL about the container ship. Also known as "The Box", with author Marc Levinson (in conversation with Sonal Chokshi and Hanne Tidnam). But this episode is really about connecting the dots between logistics, transportation, infrastructure, and much more. What do we make of the so-called "death of retail", especially when seen through the retail history of the once-largest retailer in the world? How are supply chains changing today? One thing's for sure: the shipping container made the world much smaller... and the world much economy bigger.
image: Kevin Talec / Flickr | |||
| 11 Nov 2024 | Rebuilding America's Industrial Backbone | 00:32:34 | |
America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace. In this episode, we discuss the overlooked crisis of American manufacturing and what it means for our national resilience. a16z’s Oliver Hsu hosts a conversation with founders Jordan Black (Senra Systems), Chris Power (Hadrian), and Bryon Hargis (Castelion) on why we need to revive our industrial base — and fast. From outdated regulations to the adoption of automation, they break down the “death by a thousand paper cuts” that has left our production capabilities lagging behind. Yet, it’s not all grim: these founders share how their companies are taking bold, vertically integrated approaches to reinvent the sector and reclaim America's industrial edge.
Resources: Find Chris on X: https://x.com/2112Power Find Jordan on X: https://x.com/jordan__black Find Bryon on X: https://x.com/hargsb Find Oliver on X: https://x.com/oyhsu
Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 11 Aug 2022 | Learning from Open Source Communities | 00:47:53 | |
What can we learn from the evolution of open source communities and how might they be applied to online communities and the creator economy today? Author Nadia Asparouhova joins host Sonal Choksi to talk about Asparouhova's book, Working in Public: The Making and Maintenance of Open Source Software, from Stripe Press. They start with a a taxonomy for communities, and then dig into how open source has changed over time, which learnings from open source do and don’t apply to new communities online, how communities intersect with the growing desire for more "high-shared context" groups and spaces (including even podcasts and newsletters), and more. | |||
| 06 May 2024 | Securing the Black Box: OpenAI, Anthropic, and GDM Discuss | 00:59:59 | |
Human nature fears the unknown, and with the rapid progress of AI, concerns naturally arise. Uncanny robocalls, data breaches, and misinformation floods are among the worries. But what about security in the era of large language models? In this episode, we hear from security leaders at OpenAI, Anthropic, and Google DeepMind. Matt Knight, Head of Security at OpenAI, Jason Clinton, CISO at Anthropic, and Vijay Bolina, CISO at Google DeepMind, are joined by Joel de la Garza, operating partner at a16z and former chief security officer at Box and Citigroup. Together, they explore how large language models impact security, including changes in offense and defense strategies, misuse by nation-state actors, prompt engineering, and more. In this changing environment, how do LLMs transform security dynamics? Let's uncover the answers.
Resources: Find Joel on LinkedIn: https://www.linkedin.com/in/3448827723723234/ Find Vijay Bolina on Twitter: https://twitter.com/vijaybolina Find Jason Clinton on Twitter: https://twitter.com/JasonDClinton Find Matt Knight on Twitter: https://twitter.com/embeddedsec
Stay Updated: Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. | |||
| 08 Jun 2022 | Blockchains, crypto, & web3: Connections, models, more | 00:37:15 | |
Blockchain, crypto, web3 – these terms get thrown around a lot and sometimes interchangeably, but what are the actual connections between them? And what are some mental models and analogies for thinking about this blossoming area of computer science? To dig in on these topics and more, we have another crossover episode this week, part of our occasional series where we share curated episodes from other shows that we think you’ll enjoy. This time, we’re featuring one of the first episodes from "web3 with a16z", a new show which just launched last week. Hosted by Sonal Choksi and featuring the team at a16z crypto as well as leading scientists and makers in the space, this show is about the next generation of the internet, how builders and users now have the ability to "own" pieces of the internet, unlocking a new wave of creativity and entrepreneurship. This episode features a16z crypto general partners Chris Dixon and Ali Yahya, and Tim Roughgarden, head of research at a16z crypto, in conversation with Sonal Choksi. | |||
| 14 Mar 2020 | How a16z's Crypto Startup School Went Remote | 00:13:25 | |
On February 21, Andreessen Horowitz kicked off its very first Crypto Startup School, with 45 students from around the U.S. and three countries gathering to learn how to build crypto projects. But just two weeks into the seven-week course, community spread of the novel coronavirus meant the school had to go remote — not just for the health and safety of everyone involved, but for others too, given the recommendations around social distancing and the importance of “flattening the curve”. Marketing partner Kim Milosevich and Jesse Walden, former founder of Mediachain who’s helping lead our Crypto Startup School, chat with a16z crypto editor Zoran Basich — in this hallway-style episode of the a16z Podcast — about virtual learning and collaboration in a new, uncharted world. | |||
| 08 Apr 2021 | On Monetizing Community with Patreon Cofounder Sam Yam | 00:26:14 | |
It's clear from the growth of Patreon, Substack, TikTok, Clubhouse and many more that the power of the Creator Economy continues to build. These platforms share one thing in common: They all enable independent creators to monetize their skills and products like never before. It's a trend that’s become increasingly relevant as the demand for virtual work grows.
The discussion is based on The Passion Economy and the Future of Work, a popular essay that first ran on a16z.com in October 2019. Check out that post and more creator content at: a16z.com/creatoreconomy. | |||
| 30 Sep 2019 | 16 Minutes on the News #10: Amazon Healthcare, Oculus VR/AR, Google Quantum Supremacy? | 00:22:33 | |
Our news podcast, 16 Minutes -- where we quickly cover the top headlines of the week, the a16z way (why are these topics in the news; what's real, what's hype from our vantage point of tech trends) -- is now only available as its own show feed, separately from the main a16z Podcast... so be sure to subscribe wherever you get your podcasts if you want our weekly news & tech take! This is the tenth episode of the show, and this week we cover a variety of topics with the following a16z experts:
...hosted by Sonal Chokshi. --- The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. | |||
| 27 Dec 2022 | Best Clips of 2022 | 00:43:25 | |
We’ve had some incredible guests join us on the a16z podcast this year, ranging from moonshot entrepreneurs, to top creators, to some of the most forward thinking technologists – all of which are busy shaping the future right before our eyes… We have so much more in store for 2023 and cannot wait for you to see who we bring on as guests. But before we turn the page, we wanted to recap some of the most interesting, thought-provoking segments from our 2022 roster. Here are 8 of our favorite clips, covering topics from AI to space to the metaverse… and beyond. Catch the full playlist here.
Stay Updated: Find us on Twitter: https://twitter.com/a16z Find us on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures. | |||